Physiological reserve is essential in order to respond to acute or chronic stressors. This reserve requires an adequate functional amount of parenchymal tissue in different organs systems, with a sufficient and maintained microcirculatory perfusion to supply nutrients.

We have two broad programs of investigation into the various responses in the microcirculatory, endothelial and associated glycocalyceal systems to acute and chronic stressors, with a focus on tissue responses in perturbation of these systems:

  1. Haemorrhagic shock and traumatic injury
  2. Frailty development