Peter G. Noakes is investigating the cell and molecular mechanisms that underlie the development and breakdown of the neuro-motor system. His lab works on the following: 1) cell and molecular mechanisms surrounding the establishment of neuromuscular and motor neuron (CNS) synapses, including electrophysiology. 2) The generation and development of motoneurons in health and in disease (e.g. motor neuron disease {ALS}). 3) The role of innate immune system in motor neuron health and disease. His lab employs biochemistry, immuno-histology, electrophysiology, live cell imaging, behaviour, cell and molecular biology to study these issues.