Peter G. Noakes is investigating the cell and molecular mechanisms that underlie the development and breakdown of the neuro-motor system. His lab works on the following: 1) cell and molecular mechanisms surrounding the establishment of neuromuscular and motor neuron (CNS) synapses, including electrophysiology. 2) The generation and development of motoneurons in health and in disease (e.g. motor neuron disease {ALS}, using stem cells to create motor neurons and muscle. 3) The role of inflammation in neuromuscular disorders such as motor neuron disease, muscular dystrophy, and myasthenia gravis. His lab employs biochemistry, immuno-histology, electrophysiology, live cell imaging, behaviour, cell and molecular biology to study these issues.