Our research seeks to elucidate the cellular and biochemical mechanisms by which the ubiquitin proteasome system (UPS) regulates cellular homeostasis. We use interdisciplinary approaches incorporating biochemistry, proteomics, molecular and cell biology to understand how individual ubiquitin ligase subunits specifically target their substrates. We focus particularly on understanding the regulation of centrosomes, microtubules and mitochondria. Corrupting the regulatory pathways that coordinate these organelles can have major health consequences and is the driving force behind many diseases, including cancers and neurodegenerative disorders.