Pagan Lab - Projects

We have a number of exciting projects addressing the regulation of cellular homeostasis by the ubiquitin proteasome system. 

1. Centrosomes are important organelles that play roles in cell signaling, microtubule-dependent trafficking and chromosome segregation. Our lab has ongoing projects related to the regulation of centrosome function by the ubiquitin proteasome system.  
2. Mitochondrial function is a critical determinant of cell viability. We are exploring the role of the ubiquitin proteasome system in regulating mitochondrial quality control pathways. 
3. We are seeking to develop novel ways to reactivate defective ubiquitin ligase signalling pathways in cancers.

We use a wide range of cell biology and biochemical techniques to study these questions, making our lab an ideal place to gain research experience for students, and a home for collaborators on projects of suitable interest. Our projects adopt the latest gene-editing, protein purification and mass spectrometry approaches.