Pagan Lab - Projects
We have a number of exciting projects addressing the regulation of cellular homeostasis by the ubiquitin proteasome system.
- Centrosomes are important organelles that play roles in cell signaling, microtubule-dependent trafficking and chromosome segregation. Our lab has ongoing projects related to the regulation of centrosome function by the ubiquitin proteasome system.
- Mitochondrial function is a critical determinant of cell viability. We are exploring the role of the ubiquitin proteasome system in regulating mitochondrial quality control pathways.
- We are seeking to develop novel ways to reactivate defective ubiquitin ligase signalling pathways in cancers.
We use a wide range of cell biology and biochemical techniques to study these questions, making our lab an ideal place to gain research experience for students, and a home for collaborators on projects of suitable interest. Our projects adopt the latest gene-editing, protein purification and mass spectrometry approaches.