Researcher biography

Reviews (edited list from 1999 onwards):

  1. Kruppeling Erythropoiesis: The increasing importance of DNA sequencing in human genetic disease illustrated by variants of a master regulator of erythropoiesis. Andrew Perkins, Xiangmin Xu, Douglas R. Higgs, The KLF1 Consensus Workgroup, George P. Patrinos, Lionel Arnaud, James J. Bieker and Sjaak Philipsen. Blood (2016) 127(15):1856-62 IF=11.8 Cit=2 (GS7)
  2. Macrophages and regulation of erythropoiesis. Jacobsen R, Perkins AC and Levesque J-P. Current Opinion in Hematology (2015) 22(3):212-9. IF 3.3 Cit=5 (GS8)
  3. Three Fingers on the Switch: KLF1 regulation of the g- to b-globin switch. Tallack MR and Perkins AC. Current Opinion in Hematology (2013) 20 (3):193-200. IF 3.3 Cit=22 (GS30)
  4. KLF1 Directly Coordinates Almost All Aspects of Terminal Erythroid Differentiation. Tallack MR, Perkins AC. IUBMB LIFE (2010) 62 (12); 886-890 IF 2.7 Cit=28 (GS32)
  5. Erythroid Kruppel-like factor: from fishing expedition to gourmet meal. Perkins, AC. Int J Biochem Cell Biol (1999) 31; 1175-1192. IF 4.0, Cit=48 (GS62)

Oringial Manuscripts (edited selected list from 64 total)

  1. A case-based discussion of clinical problems in the management of patients treated with ruxolitinib for myelofibrosis. P. Joy Ho, Ashish Bajel, Kate Burbury, Lindsay Dunlop, Simon Durrant, Cecily Forsyth, Andrew C. Perkins, David M. Ross. Submitted to Internal Medicine Journal. (accepted Nov 2016) IF=2.6
  2. Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and derails differentiation. Gillinder K, Ilsley M, Lajoie M, Magor G, Tallack M, Landsberg M, Bailey T, Mackay J, Bieker J, Peters L, Perkins AC. Nucleic Acids Research (accepted October 2016) IF=9.2
  3. Diagnosis in Subdural Myeloid Sarcoma. Alan Lackey, Barbara Laing, Andrew Perkins, Michael Bryant. Journal of Neuroradiology IF=2.8 (accepted September 2016).
  4. Rapid molecular profiling of myeloproliferative neoplasms using targeted exon re-sequencing of 86 genes involved in JAK-STAT signalling and epigenetic regulation. Graham W. Magor, Michael R. Tallack, Nathan M. Klose, Debbie Taylor, Darren Korbie, Peter Mollee, Matt Trau and Andrew C. Perkins. Journal of Molecular Diagnostics (2016) Sep; 18(5):707-18 IF=5.2
  5. High fat diet and the colonic mucus barrier: Implications for Obesity and Inflammatory Bowel Disease. Max Gulhane, Lydia Murray, Ran Wang, Hui Ton, Jakob Begun, Graham Magor, Tim Florin, Andrew Perkins, Michael McGuckin and Sumaira Hasnain. Scientific Reports (2016) Jun 28; 6:28990 IF=5.2
  6. The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation. Charles C. Bell, Paulo P. Amaral, Anton Kalsbeek, Graham W. Magor, Kevin R. Gillinder, Pierre Tangermann, Lorena di Lisio, Seth W. Cheetham, Franziska Gruhl, Jessica Frith, Michael R. Tallack, Ke-Lin Ru, Joanna Crawford, John S. Mattick, Marcel E. Dinger, and Andrew C. Perkins. Scientific Reports (2016) May 26; 6:26657. IF=5.2
  7. KLF1 null humans display hydrops fetalis and a deranged erythroid transcriptome. Magor G, Tallack M, Gillinder K, Williams B, Perkins AC. Blood (2015) 125(15):2405-17. IF=11.8 Cit=9 (GS12)
  8. A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis. Vannucchi AM, Kantarjian HM, Kiladjian JJ, Gotlib J, Cervantes F, Mesa RA, Sarlis NJ, Peng W, Sandor V, Gopalakrishna P, Hmissi A, Stalbovskaya V, Gupta V, Harrison C, Verstovsek S; COMFORT Investigators including Perkins AC. Haematologica (2015) 100(9):1139-45. IF=6.7 Cit=22 (GS22)
  9. Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of a-globin transgene variegation. Anabel Sorolla, Michael R. Tallack, Harald Oey, Sarah K Harten, Lucia Clemens-Daxinger, Graham W. Magor, Alex N Combes, Melissa Ilsley, Emma Whitelaw, Andrew C. Perkins. Genomics (2015) 105(2):116–122 IF=2.4 Cit=2 (GS3)
  10. A high-throughput screening strategy for detecting CRISPR-Cas9 induced mutations using next generation sequencing. Bell C, Magor G, Gillinder K, Perkins AC. BMC Genomics (2014) 15:1002 IF=3.9 Cit=13 (GS22)
  11. Heme-Bound Iron Activates Placenta Growth Factor via Erythroid Krüppel‐like Factor in Erythroid Cells. Wang X, Mendelsohn L, Rogers H, Leitman S, Tallack M, Perkins AC, Taylor JG, Noguchi CT, Kato GJ. Blood (2014) Aug 7;124(6):946-54 IF=11.8 Cit=9 (GS 11)
  12. Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes. Pattabiraman DR, Shakhbazov K, Barbier V, Krishnan K, Mukhopadhyay P, Grimmond SM, Papathanasiou P, Perkins AC, Alexander WS, Levesque J-P, Winkler, IG, and Gonda TJ. Blood (2014) Apr 24; 123(17):2682-90 IF=11.8 Cit=20 (GS 21)
  13. Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Alister P. W. Funnel, Ka Sin Mak, Natalie A. Twine, Gregory J. Pelka, Laura J. Norton, Tania Radziewic, Melinda Power, Marc R. Wilkins, Kim S. Bell-Anderson, Stuart T. Fraser, Andrew C. Perkins, Patrick P. Tam, Richard C. M. Pearson and Merlin Crossley. Mol Cel Biol. (2013) Aug; 33(15):2976-87. IF=4.2 Cit=15 (GS 18)
  14. Prediction of novel long non-coding RNAs based on RNA-Seq data of mouse Klf1 knockout study. Lei Sun, Zhihua Zhang, Timothy Bailey, Andrew C. Perkins, Michael R. Tallack and Hui Liu. BMC Bioinformatics. (2012) Dec 13; 13(1):331. IF=2.4 Cit=30 (GS 44)
  15. Novel roles for Klf1 in erythropoiesis revealed by mRNA-seq. Michael R. Tallack, Lei Sun, Graham W. Magor, Stephen Huang, Sally V. Fry, Evgeny A. Glazov, Timothy L. Bailey and Andrew C. Perkins. Genome Research (2012) Dec; 22(12):2385-98. IF=11.2 Cit=39 (GS 54)
  16. The F-BAR Protein NOSTRIN is a component of the fibroblast growth factor receptor 1 (FGFR1) Signal transduction complex and important for vascular development. Igor Kovacevic, Jiong Hu, Ann Siehoff-Icking, Nils Opitz, Aliesha Griffin, Andrew C. Perkins, Alan L. Munn, Werner Muller-Esterl, Rüdiger Popp, Benno Jungblut, Meike Hoffmeister, Stefanie Oess. EMBO J. (2012) Aug 1;31(15):3309-22 IF=9.6 Cit=15 (GS 18)
  17. The CACCC-binding protein Klf3/Bklf represses a subset of Klf1/Eklf target genes and is required for proper erythroid cell maturation in vivo. Funnell AP, Norton LJ, Mak KS, Burdach J, Artuz CM, Twine NA, Wilkins MR, Power CA, Hung TT, Perdomo J, Koh P, Bell-Anderson KS, Orkin SH, Fraser ST, Perkins AC, Pearson RCM, and Crossley MP. Mol Cel Biol. (2012) Aug; 32(16):3189-92. IF=4.2 Cit=18 (GS 24)
  18. Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis. van Zuylen WJ, Garceau V, Idris A, Schroder K, Irvine KM, Lattin JE, Ovchinnikov DA, Perkins AC, Cook AD, Hamilton JA, Hertzog PJ, Stacey KJ, Kellie S, Hume DA, Sweet MJ. PLoS One. (2011) Jan 7; 6(1):e15723. IF=3.1 Cit=19 (GS 30)
  19. A recessive screen for genes regulating hematopoietic stem cells. Papathanasiou P, Tunningley R, Pattabiraman DR, Ye P, Gonda TJ, Whittle B, Hamilton AE, Cridland SO, Lourie R, and Perkins AC. Blood (2010) 116 (26) p5858. IF=11.8 Cit=12 (GS 20)
  20. A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Tallack MR, Whitington T, Yuen WS, Wainwright EN, Keys JR, Gardiner BB, Nourbakhsh E, Cloonan N, Grimmond SM, Bailey TL, Perkins AC. Genome Research (2010) 20 (8) p1052-1063. IF=11.4 Cit=99 (GS 135)
  21. Complex architecture and regulated expression of the Sox2ot locus during vertebrate development. Paulo P. Amaral, Christine Neyt, Simon J. Wilkins, Marjan Askarian-Amiri, Susan M. Sunkin, Andrew C. Perkins, John S. Mattick. RNA (2009) Nov 15 (11):2013-27. IF=4.3 Cit=67 (GS 91)
  22. Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood. Tallack, M, and Perkins AC. Haematologica (2010) 95(1) p 144-147 IF=6.7 Cit=14 (GS 21)
  23. Ihh supports definitive erythropoiesis. Simon Cridland, Janelle Keys, Peter Papathanasiou, Andrew Perkins. Blood Cells Molecules and Diseases (2009) 43 (2) p149-155 IF=2.8 Cit=15 (GS 20)
  24. Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Karin Sonja Kassahn, Vinh Toan Dang, Simon J. Wilkins, Andrew C. Perkins, and Mark A. Ragan. Genome Research (2009) 19:1404-1418 IF=11.2 Cit=81 (GS 111)
  25. EKLF/KLF1 controls the cell cycle via direct regulation of E2f2. Tallack M, Keys JR, Humbert, PO, Perkins AC. Journal of Biological Chemistry (2009) Jul 31;284 (31):20966-74 IF=4.3 Cit=33 (GS 37)
  26. High-throughput chromatin information enables accurate tissue-specific prediction of transcription factor binding sites. Whittington T, Perkins AC, Bailey TL. Nucleic Acids Research (2009) Jan 37(1):14-25. IF=9.2 Cit=37 (GS 51)
  27. Long non-coding RNAs in mouse ES cell pluripotency and differentiation. Marcel E. Dinger, Paulo P. Amaral, Tim R. Mercer, Ken C. Pang, Stephen Bruce, Brooke Gardiner, Marjan Askarian-Amiri, Giulia M.E.A. Soldà, Cas Simons, Susan M. Sunkin, Mark L. Crowe, Sean M. Grimmond, Andrew C. Perkins, John S. Mattick. Genome Research (2008) 18(9):1433-45 IF=11.4 Cit=358 (GS 507)
  28. Stem cell transcriptome profiling via massive scale shotgun short tag sequencing. Nicole Cloonan, Alistair R.R. Forrest, Gabriel Kolle, Brooke B.A. Gardiner, Geoffrey J. Faulkner, Mellissa K. Brown, Darrin F. Taylor, Anita Steptoe, Graeme Bethel, Alan J. Robertson, Andrew C. Perkins, Stephen Bruce, Clarence Lee, Heather Peckham, Kevin McKernan, Sean M. Grimmond. Nature Methods (2008) 5(7):613-9 IF=25.3 Cit=561 (GS 859)
  29. Targeted disruption of the Basic Krüppel-like Factor (Klf3) gene reveals a role in adipogenesis. Nancy Sue, Briony Jack, Sally Eaton, Richard Pearson, Alister Funnell, Jeremy Turner, Robert Czolij, Gareth Denyer, Bob Bao, Juan Carlos Molero, David James, Andrew Perkins, Yuko Fujiwara, Stuart Orkin, Kim Bell-Anderson and Merlin Crossley. Mol Cell Biol. (2008) 28(12):3967-78 IF=4.2 Cit=65 (GS 93)
  30. A mechanism for Ikaros regulation of human globin gene switching. Keys JR, Tallack M, Crossley PM, Gaensler KML, Papathanasiou P, Smale S, Goodnow CC, Perkins AC. Br J Haematol (2008) 141(3):398-406 IF=5.4 Cit=24 (GS 35)
  31. Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation. Wilkins SJ, Yoong S, Verkade H, Mizoguchi T, Plowman SJ, Hancock JF, Kikuchi Y, Heath JK, and Perkins AC. Developmental Biology (2008) 314 (1):12-22 IF=3.2 Cit=19 (GS20)
  32. Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-free (BMP4) culture. Stephen Bruce, Brooke Gardiner, Lez Burke, Simon Cridland, Anita Steptoe, Jack Flanagan, Milena Gongora, Sean Grimmond and Andrew Perkins. BMC Genomics (2007) 8 (1):365 IF=3.9 Cit=45 (GS 65)
  33. A global role for zebrafish klf4 in embryonic erythropoiesis. Gardiner M, Gongora M, Grimmond S, Perkins AC. Mech. Dev. (2007) 124 (9-10):762-74 IF=2.0 Cit=28 (GS 39)
  34. Erythroid Kruppel-like factor regulates the G1 cyclin dependent kinase inhibitor, p18INK4c. Tallack M, Keys JR, Perkins AC. J. Mol. Biol. (2007) 369 (2):313-21 IF=4.3 Cit=24 (GS 25)
  35. In vitro differentiation of murine embryonic stem cells toward a renal lineage. Stephen J Bruce, Ashley L Rossiter, Anita L Steptoe, Meinrad Busslinger, John F Bertram & Andrew C Perkins. Differentiation (2007) 75(5):337-49 IF=2.5 Cit=69 (GS 92)
  36. Erythroid Krüppel-like Factor Directly Activates the Basic Krüppel-like Factor Gene in Erythroid Cells. Alister P.W. Funnell, Chris A. Maloney, Lucinda J. Thompson, Janelle Keys, Michael Tallack, Andrew Perkins and Merlin Crossley. Mol Cell Biol. 27 (7):2777-90 (2007). IF=4.4 Cit=54 (GS 75)
  37. Genomic organisation and regulation of murine alpha haemoglobin stabilising protein by erythroid Kruppel-like factor. Janelle Keys, Michael Tallack, Denise Hodge, Simon Cridland, Rakesh David, and Andrew Perkins. Br J Haematol. 136, 150–157 (2007) IF=5.4 Cit=18 (GS 24)
  38. Human KLF17 is a new member of the Sp/KLF family of transcription factors. Jane van Vliet, Linda A. Crofts, Andrew C. Perkins and Merlin Crossley. Genomics 87 (4): 474-482 (2006). IF 2.3 Cit=59 (GS 85)
  39. A global role for EKLF in definitive and primitive haematopoiesis. Hodge D, Coghill E, Maguire T, Keys J, Hartmann B, Weiss, M, McDowell, A, Grimmond S, Perkins AC. Blood 107 (8): 3357-3370 (2006) IF=11.8 Cit=131 (GS 191)
  40. Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching. Gardiner MR, Daggett DF, Zon LI, and Perkins AC. Dev. Dyn Dec; 234 (4):992-6 (2005) IF 2.2 Cit=16 (GS 21)
  41. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Papathanasiou P, Perkins AC, Cobb BS, et al. Immunity 19 (1) p 131-144 (2003) IF=24.1 Cit=93 (GS 125)
  42. Neptune, a Kruppel-like transcription factor that participates in primitive erythropoiesis in Xenopus. Huber T, Perkins AC, Deconinck A, Chan F-Y, Mead PE, and Zon LI. Current Biology, 11: 1456-1461 (2001) IF=9.0 Cit=35 (GS 43)
  43. Erythroid Kruppel-like factor (EKLF) co-ordinates erythroid cell proliferation and haemoglobinisation in cell lines derived from EKLF-/- mice. Coghill E, Eccleston S, Brown C, Fox V, Cerutti L, Jane S, Cunningham J, and Perkins AC. Blood 97, 1861-1868 (2001). IF=11.8 Cit=61 (GS 79)
  44. An essential role in liver development for transcription factor XBP-1. Reimold AM, Etkin A, Clauss I, Perkins AC, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH. Genes Dev.; 14 (2):152-7 (2000). IF=10.0 Cit=295 (GS 419)
  45. SEK1 deficiency reveals mitogen-activated protein kinase cascade cross-regulation and leads to abnormal hepatogenesis. Ganiatsas S, Kwee L, Fujiwara Y, Perkins AC, Ikeda T, Orkin SH, Lebow MA, and Zon LI. PNAS 95 (12):6881-6 (1998). IF 9.4 Cit=161 (GS 202)
  46. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Keiran MW, Perkins AC, Orkin SH and Zon LI. PNAS 93; 9126-9131 (1996) IF=9.4 Cit=128 (GS 168)
  47. Silencing of human fetal-globin expression is impaired in the absence of the adult b-globin gene activator protein, EKLF. Perkins AC, Gaensler KML, Orkin, SH. PNAS 93; 12267-12271 (1996). IF=9.4 Cit=117 (GS 142)
  48. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box binding protein in erythroid cells and selected other cells. Crossley MP, Whitelaw E, Perkins AC, Williams G, Fujiwara Y, Orkin SH. Mol. Cell. Biol. 16 (4); 1695-1705 (1996). IF 4.2 Cit=182 (GS 214)
  49. Lethal beta-thalassemia in mice lacking the erythroid CACCC-transcription factor EKLF. Perkins AC, Sharp AH, Orkin SH. Nature 375; 318-322 (1995). IF=38.1 Cit=455 (GS 565)
  50. Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene. Perkins AC, Cory S. EMBO J 12; 3835-3846 (1993). IF=9.6 Cit=90 (GS 100)
  51. Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia. Perkins AC, Kongsuwan K, Visvader J, Adams JM, Cory S. PNAS 87; 8398-8402 (1990). IF 9.4 Cit=172 (GS 163)