Dr Stephen Edwards
Senior Research Assistant
School of Biomedical Sciences
Journal Articles
Chen, Min, Tieng, Quang M., Du, Jiaxin, Edwards, Stephen R., Maskey, Dhiraj, Peshtenski, Emil and Reutens, David (2023). Effects of C1-INH treatment on neurobehavioral sequelae and late seizures after traumatic brain injury in a mouse model of controlled cortical impact. Neurotrauma Reports, 4 (1), 124-136. doi: 10.1089/neur.2022.0011
Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease. Clinical and Experimental Pharmacology and Physiology, 47 (10) 1440-1681.13363, 1740-1750. doi: 10.1111/1440-1681.13363
Chen, Min, Edwards, Stephen R. and Reutens, David C. (2020). Complement in the Development of Post-Traumatic Epilepsy: Prospects for Drug Repurposing. Journal of Neurotrauma, 37 (5), 692-705. doi: 10.1089/neu.2019.6942
Smith, Maree T., Wyse, Bruce D., Edwards, Stephen R., El-Taminy, Mahmoud, Gaetano, Giacinto and Gavin, Paul (2015). Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture, TPM) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure. Journaal of Pharmaceutical Sciences, 104 (7), 2388-2396. doi: 10.1002/jps.24502
Edwards, Stephen R., Hamlin, Adam S., Marks, Nicola, Coulson, Elizabeth J. and Smith, Maree T. (2014). Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 41 (10), 798-806. doi: 10.1111/1440-1681.12277
Smith, Maree T., Wyse, Bruce D. and Edwards, Stephen R. (2013). Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats. Pain Medicine, 14 (5), 692-705. doi: 10.1111/pme.12063
South, Samantha M., Edwards, Stephen R. and Smith, Maree T. (2009). Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests. Clinical and Experimental Pharmacology and Physiology, 36 (1), 20-28. doi: 10.1111/j.1440-1681.2008.05019.x
Hemstapat, K., Le, L., Edwards, S. R. and Smith, M. T. (2009). Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration. Pharmacology, Biochemistry and Behaviour, 93 (4), 498-505. doi: 10.1016/j.pbb.2009.06.016
Chan, S., Edwards, S. R., Wyse, B. D. and Smith, M. T. (2008). Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat. Clinical and Experimental Pharmacology and Physiology, 35 (3), 295-302. doi: 10.1111/j.1440-1681.2007.04821.x
Edwards, S. R., Mather, L. E. and Smith, M. T. (2007). Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats. Clinical and Experimental Pharmacology and Physiology, 34 (5-6), 414-420. doi: 10.1111/j.1440-1681.2007.04581.x
Edwards, Stephen R. and Smith, Maree T. (2007). Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B, 848 (2), 264-270. doi: 10.1016/j.jchromb.2006.10.039
Smith, Maree T., Edwards, Stephen R. and Nielsen, Carsten K. (2007). Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration. Anesthesiology, 106 (5), 1063-1064. doi: 10.1097/01.anes.0000265176.75372.ed
Nielsen, Carsten K., Ross, Fraser B., Lotfipour, Shahrdad, Saini, Kamal S., Edwards, Stephen R. and Smith, Maree T. (2007). Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain, 132 (3), 289-300. doi: 10.1016/j.pain.2007.03.022
Edwards, S. R. and Smith, M. T. (2005). Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B, 814 (2), 241-249. doi: 10.1016/j.jchromb.2004.10.035
Huang, L., Edwards, S. R. and Smith, M. T. (2005). Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes. Pharmaceutical Research, 22 (9), 1489-1498. doi: 10.1007/s11095-005-6154-y
Edwards, Stephen R. and Mather, Laurence E. (2003). Alfentanil potentiates anaesthetic and electroencephalographic responses to ketamine in the rat. European Journal of Pharmacology, 460 (1), 27-35. doi: 10.1016/s0014-2999(02)02827-3
Edwards, Stephen R. and Mather, Laurence E. (2003). Diclofenac increases the accumulation of kynurenate following tryptophan pretreatment in the rat: a possible factor contributing to its antihyperalgesic effect. Inflammopharmacology, 11 (3), 277-292. doi: 10.1163/156856003322315622
Edwards, S. R., Minto, C. F. and Mather, L. E. (2002). Concurrent ketamine and alfentanil administration: pharmacokinetic considerations. British Journal of Anaesthesia, 88 (1), 94-100. doi: 10.1093/bja/88.1.94
Edwards, S. R. and Mather, L. E. (2001). Tissue uptake of ketamine and norketamine enantiomers in the rat: indirect evidence for extrahepatic metabolic inversion. Life Sciences, 69 (17), 2051-2066. doi: 10.1016/s0024-3205(01)01287-5
Grace, Robert F., Lin, Yiguang, Power, Ian, Edwards, Stephen R. and Mather, Laurence E. (2001). Effects of diclofenac in the rat tail ischaemia--reperfusion injury model of acute hyperalgesia. Pain, 89 (2-3), 117-125. doi: 10.1016/s0304-3959(00)00372-9
Edwards, Stephen R., Mather, Laurence E., Lin, Yiguang, Power, Ian and Cousins, Michael J. (2000). Glutamate and kynurenate in the rat central nervous system following treatments with tail ischaemia or diclofenac. The Journal of Pharmacy and Pharmacology, 52 (1), 59-66. doi: 10.1211/0022357001773698
Mather, L. E., Edwards, S. R., Duke, C. C. and Cousins, M. J. (2000). Microdialysis study of the blood-brain equilibration of thiopental enantiomers. British Journal of Anaesthesia, 84 (1), 67-73. doi: 10.1093/oxfordjournals.bja.a013385
Mather, Laurence E., Edwards, Stephen R. and Duke, Colin C. (1999). Electroencephalographic effects of thiopentone and its enantiomers in the rat. Life Sciences, 66 (2), 105-114. doi: 10.1016/s0024-3205(99)00568-8
Mather, Laurence E., Edwards, Stephen R. and Duke, Colin C. (1999). Electroencephalographic effects of thiopentone and its enantiomers in the rat: correlation with drug tissue distribution. British Journal of Pharmacology, 128 (1), 83-91. doi: 10.1038/sj.bjp.0702745
Mather, Laurence E., Edwards, Stephen R., Duke, Colin C. and Cousins, Michael J. (1999). Enantioselectivity of thiopental distribution into the central neural tissue of rats: an interaction with halothane. Anesthesia and Analgesia, 89 (1), 230-235. doi: 10.1097/00000539-199907000-00042
Mather, Laurence E. and Edwards, Stephen R. (1998). Chirality in anaesthesia--ropivacaine, ketamine and thiopentone. Current Opinion in Anaesthesiology, 11 (4), 383-390. doi: 10.1097/00001503-199808000-00002
Smythe, G. A. and Edwards, S. R. (1992). Suppression of central noradrenergic neuronal activity inhibits hyperglycemia. American Journal of Physiology, 263 (5 Pt 1), E823-E827. doi: 10.1152/ajpendo.1992.263.5.E823
Smythe, George A. and Edwards, Stephen R. (1991). A role for central postsynaptic alpha 2-adrenoceptors in glucoregulation. Brain Research, 562 (2), 225-229. doi: 10.1016/0006-8993(91)90625-6
Jackson, D. M., Ross, S. B. and Edwards, S. R. (1989). Dopamine D2 agonist-induced behavioural depression is reversed by dopamine D1 agonists. Journal of Neural Transmission, 75 (3), 213-220. doi: 10.1007/BF01258632
Ross, S. B., Jackson, D. M. and Edwards, S. R. (1989). The involvement of dopamine D1 and D2 receptors in the locomotor stimulation produced by (+)-amphetamine in naive and dopamine-depleted mice. Pharmacology and Toxicology, 64 (1), 72-77. doi: 10.1111/j.1600-0773.1989.tb00604.x
Ross, S. B., Jackson, D. M., Wallis, E. M. and Edwards, S. R. (1988). Enhancement by a single dose of reserpine (plus alpha methyl-p-tyrosine) of the central stimulatory effects evoked by dopamine D-1 and D-2 agonists in the mouse. Naunyn-Schmiedeberg's Archives of Pharmacology, 337 (5), 512-8. doi: 10.1007/BF00182724
Edwards, Steven, Jackson, David, Reynoldson, James and Shanley, Brian (1984). Neuropharmacology of δ-aminolaevulinic acid. II. Effect of chronic administration in mice. Neuroscience Letters, 50 (1-3), 169-173. doi: 10.1016/0304-3940(84)90481-6
Edwards, S. R., Shanley, B. C. and Reynoldson, J. A. (1984). Neuropharmacology of delta-aminolaevulinic acid-I Effect of acute administration in rodents. Neuropharmacology, 23 (4), 477-481. doi: 10.1016/0028-3908(84)90259-4
Conference Papers
Edwards, Stephen R., Coulson, Elizabeth J. and Smith, Maree T. (2010). A behavioural study assessing memory deficits in the APP/PS1 double transgenic mouse model of Alzheimer’s disease using the Morris water maze.. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) 44th Annual Scientific Meeting 2010, Melbourne, Australia, 28 November-1 December 2010. Melbourne, Australia: ASCEPT.
Edwards, Stephen and Smith, M.T. (2009). A study of the application of the Morris water maze to the establishment of a preclinical model of Alzheimer's disease in the rat. ASCEPT 43rd Annual Scientific Meeting 2009: The Rights of Medicines, Darling Harbour, NSW, Australia, 29 November-2 December 2009.
Edwards, S. R., Mather, L. E. and Smith, M. T. (2005). Antihyperalgesic and anti-inflammatory effects of RS- & S-ketamine in freunds complete adjuvant (FCA)-induced inflammation. 11th World Congress on Pain, Sydney, 21-26 August 2005. USA: IASP Press.
Edwards, S. R. and Smith, M. T. (2004). Determination of morphine, oxycodone, morphine-3-glucuronide, & noroxycodone concentrations in rat serum by liquid chromatography (LC) - electrospray mass spectrometry (EMS). CPT2004, Brisbane, 1-6 August 2004. Australia: Blackwell Publishing.
Huang, L., Edwards, S. R. and Smith, M. T. (2004). Comparative pharmacokinetics and metabolism of subcutaneous oxycodone in male dark agouti relative to sprague-dawley rats. CTP 2004, Brisbane, 1-6 August 2004. Australia: Blackwell Publishing Asia.
Edwards, S. R. and Smith, M. T. (2003). Quantification of morphine, oxycodone, morphine-3-glucuronide and noroxycodone in rat serum by high performance liquid chromatography (HPLC-electrospray mass spectrometry (EMS). Annual Scientific Meeting of ASCEPT 2003, Sydney, 30 November - 3 December 2003. Melbourne: ASCEPT.
Huang, L., Le, L., Edwards, S. R. and Smith, M. T. (2003). Serum concentrations of metabolically-derived oxymorphone are insignificant in diabetic and non-diabetic adult male Dark Agouti rats following subcutaneous oxycodone bolus administration: Comparison with Sprague-Dawley rats. Annual Scientific Meeting of ASCEPT, Sydney, 30 November - 3 December 2003. Melbourne: ASCEPT.