Associate Professor Enzo Porrello
Honorary Associate Professor
School of Biomedical Sciences
PhD and MPhil Supervision
- View current and completed supervisions on UQ Researchers.
Find out more information on how to apply for a Research Higher Degree (MPhil or PhD) with the School. For all enquiries regarding research supervision, please contact ask@uq.edu.au.
Book Chapter
Mills, Richard J., Voges, Holly K., Porrello, Enzo R. and Hudson, James E. (2017). Cryoinjury model for tissue injury and repair in bioengineered human striated muscle. In Skeletal Muscle Development (pp. 209-224) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-7283-8_15
Journal Articles
Sim, Choon Boon, Phipson, Belinda, Ziemann, Mark, Rafehi, Haloom, Mills, Richard J., Watt, Kevin I., Abu-Bonsrah, Kwaku D., Kalathur, Ravi K.R., Voges, Holly K., Dinh, Doan T., Ter Huurne, Menno, Vivien, Celine J., Kaspi, Antony, Kaipananickal, Harikrishnan, Hidalgo, Alejandro, Delbridge, Leanne M.D., Robker, Rebecca L., Gregorevic, Paul, Dos Remedios, Cristobal G., Lal, Sean, Piers, Adam T., Konstantinov, Igor E., Elliott, David A., El-Osta, Assam, Oshlack, Alicia, Hudson, James E. and Porrello, Enzo R. (2021). Sex-specific control of human heart maturation by the progesterone receptor. Circulation, 143 (16), 1614-1628. doi: 10.1161/CIRCULATIONAHA.120.051921
Vivien, Celine J., Pichol-Thievend, Cathy, Sim, Choon Boon, Smith, Jacob B., Bower, Neil, Hogan, Benjamin M., Hudson, James E., Francois, Mathias and Porrello, Enzo R. (2019). Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context. Npj Regenerative Medicine, 4 (1) 18, 18. doi: 10.1038/s41536-019-0079-2
Mills, Richard J., Parker, Benjamin L., Quaife-Ryan, Gregory A., Voges, Holly K., Needham, Elise J., Bornot, Aurelie, Ding, Mei, Andersson, Henrik, Polla, Magnus, Elliott, David A., Drowley, Lauren, Clausen, Maryam, Plowright, Alleyn T., Barrett, Ian P., Wang, Qing-Dong, James, David E., Porrello, Enzo R. and Hudson, James E. (2019). Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway. Cell Stem Cell, 24 (6), 895-907. doi: 10.1016/j.stem.2019.03.009
Mills, Richard J., Parker, Benjamin L., Monnot, Pauline, Needham, Elise. J., Vivien, Celine J., Ferguson, Charles, Parton, Robert G., James, David E., Porrello, Enzo R. and Hudson, James E. (2019). Development of a human skeletal micro muscle platform with pacing capabilities. Biomaterials, 198, 217-227. doi: 10.1016/j.biomaterials.2018.11.030
Anderson, David J., Kaplan, David I., Bell, Katrina M., Koutsis, Katerina, Haynes, John M., Mills, Richard J., Phelan, Dean G., Qian, Elizabeth L., Leitoguinho, Ana Rita, Arasaratnam, Deevina, Labonne, Tanya, Ng, Elizabeth S., Davis, Richard P., Casini, Simona, Passier, Robert, Hudson, James E., Porrello, Enzo R., Costa, Mauro W., Rafii, Arash, Curl, Clare L., Delbridge, Lea M., Harvey, Richard P., Oshlack, Alicia, Cheung, Michael M., Mummery, Christine L., Petrou, Stephen, Elefanty, Andrew G., Stanley, Edouard G. and Elliott, David A. (2018). NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Nature Communications, 9 (1) 1373, 1373. doi: 10.1038/s41467-018-03714-x
Dang, Louis T., Tondl, Markus, Chiu, Man Ho H., Revote, Jerico, Paten, Benedict, Tano, Vincent, Tokolyi, Alex, Besse, Florence, Quaife-Ryan, Greg, Cumming, Helen, Drvodelic, Mark J., Eichenlaub, Michael P., Hallab, Jeannette C., Stolper, Julian S., Rossello, Fernando J., Bogoyevitch, Marie A., Jans, David A., Nim, Hieu T., Porrello, Enzo R., Hudson, James E. and Ramialison, Mirana (2018). TrawlerWeb: an online de novo motif discovery tool for next-generation sequencing datasets. BMC Genomics, 19 (1) 238, 238. doi: 10.1186/s12864-018-4630-0
Mills, Richard J, Voges, Holly K, Porrello, Enzo R and Hudson, James E (2018). Disease modeling and functional screening using engineered heart tissue. Current Opinion in Physiology, 1, 80-88. doi: 10.1016/j.cophys.2017.08.003
Hudson, James E. and Porrello, Enzo R. (2017). FunSel mesenchymal stromal cells stay for the party. Circulation, 136 (16), 1525-1527. doi: 10.1161/CIRCULATIONAHA.117.030795
Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R. and Hudson, James E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proceedings of the National Academy of Sciences of the United States of America, 114 (40), E8372-E8381. doi: 10.1073/pnas.1707316114
Hudson, James E. and Porrello, Enzo R. (2017). Periostin paves the way for neonatal heart regeneration. Cardiovascular Research, 113 (6), 556-558. doi: 10.1093/cvr/cvx039
Kaakinen, Mika, Reichelt, Melissa E., Ma, Zhibin, Ferguson, Charles, Martel, Nick, Porrello, Enzo R., Hudson, James E., Thomas, Walter G., Parton, Robert G. and Headrick, John P. (2017). Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity. Basic Research in Cardiology, 112 (3) 24, 24. doi: 10.1007/s00395-017-0613-6
Voges, Holly K., Mills, Richard J., Elliott, David A., Parton, Robert G., Porrello, Enzo R. and Hudson, James E. (2017). Development of a human cardiac organoid injury model reveals innate regenerative potential. Development, 144 (6), 1118-1127. doi: 10.1242/dev.143966
Vivien, Celine J., Hudson, James E. and Porrello, Enzo R. (2016). Evolution, comparative biology and ontogeny of vertebrate heart regeneration. NPJ Regenerative Medicine, 1 doi: doi:10.1038/npjregenmed.2016.12
Vivien, Celine J, Hudson, James E and Porrello, Enzo R (2016). Evolution, comparative biology and ontogeny of vertebrate heart regeneration. NPJ Regenerative medicine, 1 (1) 16012, 16012. doi: 10.1038/npjregenmed.2016.12
Titmarsh, Drew M., Glass, Nick R., Mills, Richard J., Hidalgo, Alejandro, Wolvetang, Ernst J., Porrello, Enzo R., Hudson, James E. and Cooper-White, Justin J. (2016). Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays. Scientific Reports, 6 (1) 24637, 24637. doi: 10.1038/srep24637
Quaife-Ryan, Gregory A., Sim, Choon Boon, Porrello, Enzo R. and Hudson, James E. (2016). Resetting the epigenome for heart regeneration. Seminars in Cell and Developmental Biology, 58, 2-13. doi: 10.1016/j.semcdb.2015.12.021
Morrison, Janna L, Zhang, Song, Tellam, Ross L, Brooks, Doug A, McMillen, I Caroline, Porrello, Enzo R and Botting, Kimberley J (2015). Regulation of microRNA during cardiomyocyte maturation in sheep. BMC Genomics, 16 (541) 541, 541. doi: 10.1186/s12864-015-1693-z
Foster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, Dos Remedios, Cristobal G., Thomas, Walter G. and Ramialison, Mirana (2015). Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 388 (10) 1118, 1009-1027. doi: 10.1007/s00210-015-1118-1
Sim, Choon Boon, Ziemann, Mark, Kaspi, Antony, Harikrishnan, K. N., Ooi, Jenny, Khurana, Ishant, Chang, Lisa, Hudson, James E., El-Osta, Assam and Porrello, Enzo R. (2015). Dynamic changes in the cardiac methylome during postnatal development.. Faseb Journal, 4 (4), 1329-1343. doi: 10.1096/fj.14-264093
Bernardo, Bianca C., Nguyen, Sally S., Winbanks, Catherine E., Gao, Xiao-Ming, Boey, Esther J. H., Tham, Yow Keat, Kiriazis, Helen, Ooi, Jenny Y. Y., Porrello, Enzo R., Igoor, Sindhu, Thomas, Colleen J., Gregorevic, Paul, Lin, Ruby C. Y., Du, Xiao-Jun and McMullen, Julie R. (2014). Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy. FASEB Journal, 28 (12), 5097-5110. doi: 10.1096/fj.14-253856
Porrello, Enzo R. and Olson, Eric N. (2014). A neonatal blueprint for cardiac regeneration. Stem Cell Research, 13 (3), 556-570. doi: 10.1016/j.scr.2014.06.003
Frith, Jessica E., Porrello, Enzo R. and Cooper-White, Justin J. (2014). Concise review: new frontiers in MicroRNA-based tissue regeneration. Stem Cells Translational Medicine, 3 (8), 969-976. doi: 10.5966/sctm.2014-0032
Mahmoud, Ahmed I., Porrello, Enzo R., Kimura, Wataru, Olson, Eric N. and Sadek, Hesham A. (2014). Surgical models for cardiac regeneration in neonatal mice. Nature Protocols, 9 (2), 305-311. doi: 10.1038/nprot.2014.021
Hudson, James E. and Porrello, Enzo R. (2013). The non-coding road towards cardiac regeneration. Journal of Cardiovascular Translational Research, 6 (6), 909-923. doi: 10.1007/s12265-013-9486-8
Porrello, Enzo R. (2013). microRNAs in cardiac development and regeneration. Clinical Science, 125 (4), 151-166. doi: 10.1042/CS20130011
Mahmoud, Ahmed I., Kocabas, Fatih, Muralidhar, Shalini A., Kimura, Wataru, Koura, Ahmed S., Thet, Suwannee, Porrello, Enzo R. and Sadek, Hesham A. (2013). Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature, 497 (7448), 249-253. doi: 10.1038/nature12054
Foster, Simon R., Porrello, Enzo R., Purdue, Brooke, Chan, Hsiu-Wen, Voigt, Anja, Frenzel, Sabine, Hannan, Ross D., Moritz, Karen M., Simmons, David G., Molenaar, Peter, Roura, Eugeni, Boehm, Ulrich, Meyerhof, Wolfgang and Thomas, Walter G. (2013). Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart. PLoS ONE, 8 (5) e64579, e64579-1-e64579-10. doi: 10.1371/journal.pone.0064579
Porrello, Enzo R., Mahmoud, Ahmed I., Simpson, Emma, Johnson, Brett A., Grinsfelder, David, Canseco, Diana, Mammen, Pradeep P., Rothermel, Beverly A., Olson, Eric N. and Sadek, Hesham A. (2013). Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proceedings of the National Academy of Sciences of the United States of America, 110 (1), 187-192. doi: 10.1073/pnas.1208863110
Xin, Mei, Kim, Yuri, Sutherland, Lillian B., Murakami, Masao, Qi, Xiaoxia, McAnally, John, Porrello, Enzo R., Mahmoud, Ahmed I., Tan, Wei, Shelton, John M., Richardson, James A., Sadek, Hesham A., Bassel-Duby, Rhonda and Olson, Eric N. (2013). Hippo pathway effector Yap promotes cardiac regeneration. Proceedings of the National Academy of Sciences of the United States of America, 110 (34), 13839-13844. doi: 10.1073/pnas.1313192110
Kocabas, Fatih, Mahmoud, Ahmed I., Sosic, Drazen, Porrello, Enzo R., Chen, Rui, Garcia, Joseph A., DeBerardinis, Ralph J. and Sadek, Hesham A. (2012). The hypoxic epicardial and subepicardial microenvironment. Journal of Cardiovascular Translational Research, 5 (5), 654-665. doi: 10.1007/s12265-012-9366-7
Mahmoud, Ahmed I. and Porrello, Enzo R. (2012). Turning back the cardiac regenerative clock: lessons from the neonate. Trends in Cardiovascular Medicine, 22 (5), 128-133. doi: 10.1016/j.tcm.2012.07.008
Porrello, Enzo R., Pfleger, Kevin D. G., Seeber, Ruth M., Qian, Hongwei, Oro, Cristina, Abogadie, Fe, Delbridge, Lea M. D. and Thomas, Walter G. (2011). Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles. Cellular Signalling, 23 (11), 1767-1776. doi: 10.1016/j.cellsig.2011.06.011
O'Callaghan, E.L., Bassi, J.K., Porrello, E.R., Delbridge, L.M.D., Thomas, W.G. and Allen, A.M. (2011). Regulation of angiotensinogen by angiotensin II in mouse primary astrocyte cultures. Journal of Neurochemistry, 119 (1), 18-26. doi: 10.1111/j.1471-4159.2011.07406.x
Porrello, Enzo R., Johnson, Brett A., Aurora, Arin B., Simpson, Emma, Nam, Young-Jae, Matkovich, Scot J., Dorn, Gerald W., II, van Rooij, Eva and Olson, Eric N. (2011). miR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circulation Research, 109 (6), 670-679. doi: 10.1161/CIRCRESAHA.111.248880
Porrello, Enzo R., Mahmoud, Ahmed I., Simpson, Emma, Hill, Joseph A., Richardson, James A., Olson, Eric N. and Sadek, Hesham A. (2011). Transient regenerative potential of the neonatal mouse heart. Science, 331 (6020), 1078-1080. doi: 10.1126/science.1200708
Porrello, Enzo R. and Olson, Eric N. (2010). Building a new heart from old parts: stem cell turnover in the aging heart. Circulation Research, 107 (11), 1292-1294. doi: 10.1161/CIRCRESAHA.110.235168
Gezmish, Oksan, Tare, Marianne, Parkington, Helena C., Morley, Ruth, Porrello, Enzo R., Bubb, Kristen J. and Black, Mary Jane (2010). Maternal vitamin D deficiency leads to cardiac hypertrophy in rat offspring. Reproductive Sciences, 17 (2), 168-176. doi: 10.1177/1933719109349536
Porrello, Enzo R. and Delbridge, Lea M. D. (2009). Cardiomyocyte autophagy is regulated by angiotensin II type 1 and type 2 receptors. Autophagy, 5 (8), 1215-1216. doi: 10.4161/auto.5.8.10153
Porrello, Enzo R, Meeker, William F, Thomas, Walter G, Widdop, Robert E and Delbridge, Lea MD (2009). Glucocorticoids Suppress Growth in Neonatal Cardiomyocytes Co-Expressing AT(2) and AT(1) Angiotensin Receptors. Neonatology, 97 (3), 257-265. doi: 10.1159/000253757
Porrello, Enzo R., Bell, James R., Schertzer, Jonathan D., Curl, Claire L., McMullen, Julie R., Mellor, Kimberley M., Ritchie, Rebecca H., Lynch, Gordon S., Harrap, Stephen B., Thomas, Walter G. and Delbridge, Lea M. D. (2009). Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 296 (3), R672-R680. doi: 10.1152/ajpregu.90919.2008
Porrello, Enzo R., Delbridge, Lea M. D. and Thomas, Walter G. (2009). The angiotensin II type 2 (AT(2)) receptor: an enigmatic seven transmembrane receptor. Frontiers in Bioscience, 14 (3), 958-972. doi: 10.2741/3289
Porrello, Enzo R., D'Amore, Angelo, Curl, Claire L., Allen, Andrew M., Harrap, Stephen B., Thomas, Walter G. and Delbridge, Lea M. D. (2009). Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor-Mediated Cardiomyocyte Autophagy. Hypertension, 53 (6), 1032-1040. doi: 10.1161/HYPERTENSIONAHA.108.128488
Porrello, Enzo R., Widdop, Robert E. and Delbridge, Lea M. D. (2008). Early origins of cardiac hypertrophy: does cardiomyocyte attrition programme for pathological 'Catch-Up' growth of the heart?. Clinical and Experimental Pharmacology and Physiology, 35 (11), 1358-1364. doi: 10.1111/j.1440-1681.2008.05036.x
Bell, James R., Porrello, Enzo R., Huggins, Catherine E., Harrap, Stephen B. and Delbridge, Lea M. D. (2008). The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy. American Journal of Physiology, 294 (4), H1514-H1522. doi: 10.1152/ajpheart.01283.2007
Porrello, E. R., Curl, C. L., Harrap, S. B., Thomas, W. G. and Delbridge, L. M. D. (2006). Post-natal cardiac development in an experimental model of normotensive cardiac hypertrophy. Journal of Molecular and Cellular Cardiology, 41 (4), 744-744. doi: 10.1016/j.yjmcc.2006.06.047
Porrello, Enzo R., Huggins, Catherine E., Curl, Claire L., Domenighetti, Andrea A., Pedrazzini, Thierry, Delbridge, Leanne M. D. and Morgan, Trefor O. (2004). Elevated dietary sodium intake exacerbates myocardial hypertrophy associated with cardiac-specific overproduction of angiotensin II. Journal of the Renin-Angiotensin-Aldosterone System, 5 (4), 169-175. doi: 10.3317/jraas.2004.036
Conference Paper
Foster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, dos Remedios, Cris G., Thomas, Walter G. and Ramialison, Mirana (2015). Transcriptional Regulation of Taste Receptor Genes: Novel Insights From In Silico and Cardiac Gene Expression Analyses. 15th Scientific Meeting of the Australasian Association for ChemoSensory Science (AACSS), Brisbane, QLD Australia, 03-05 December 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjv008