James is developing novel miniaturised conotoxins for the treatment of pain and is investigating how these peptides interact with the GABA(B) receptor.
Book Chapter
Daniel, James T. and Clark, Richard J. (2017). Molecular Engineering of Conus Peptides as Therapeutic Leads. Peptides and Peptide-based Biomaterials and their Biomedical Applications. (pp. 229-254) Cham, Switzerland: Springer. doi: 10.1007/978-3-319-66095-0_10
Journal Articles
Sadeghi, Mahsa, Carstens, Bodil B., Callaghan, Brid P., Daniel, James T., Tae, Han Shen, O'Donnell, Tracey, Castro, Joel, Brierley, Stuart M., Adams, David J., Craik, David J. and Clark, Richard J. (2018). Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1. ACS Chemical Biology, 13 (6), 1577-1587. doi: 10.1021/acschembio.8b00190
Daniel, James T. and Clark, Richard J. (2017). G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides. Toxins, 9 (11) 372, 1-26. doi: 10.3390/toxins9110372
Carstens, Bodil B., Berecki, Geza, Daniel, James T., Lee, Han Siean, Jackson, Kathryn A. V., Tae, Han-Shen, Sadeghi, Mahsa, Castro, Joel, O'Donnell, Tracy, Deiteren, Annemie, Brierley, Stuart M., Craik, David J., Adams, David J. and Clark, Richard J. (2016). Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie - International Edition, 55 (15), 4692-4696. doi: 10.1002/anie.201600297
Tian, Ye, Daniel, J. T. and Meehan, Paul A. (2015). Real-time rail–wheel wear damage control. International Journal of Rail Transportation, 4 (2), 113-129. doi: 10.1080/23248378.2015.1121411