School of Biomedical Sciences School of Biomedical Sciences
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Associate Professor Christophe Rosty

Publications

Journal Articles (112)
Conference Papers (29)

Journal Articles

A morphological and molecular study of proposed early forms of the traditional serrated adenoma
DNA mismatch repair protein deficient non-neoplastic colonic crypts: a novel indicator of Lynch syndrome
Assessing the ProMCol classifier as a prognostic marker for non-metastatic colorectal cancer within the Melbourne Collaborative Cohort Study
Sessile serrated adenomas in young patients may have limited risk of malignant progression
Associations of alcohol intake, smoking, physical activity and obesity with survival following colorectal cancer diagnosis by stage, anatomic site and tumor molecular subtype
The Role of the Surgical Pathologist in the Diagnosis of Gastrointestinal Polyposis Syndromes
The role of APC in WNT pathway activation in serrated neoplasia
Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry
Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes
Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort
Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas
RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers
Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn’s disease-related ileitis
Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study
Findings in young adults at colonoscopy from a hospital service database audit
Lifetime alcohol intake is associated with an increased risk of KRAS+ and BRAF-/KRAS- but not BRAF+ colorectal cancer
Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers
Reducing the polyp burden in serrated polyposis by serial colonoscopy: the impact of nationally coordinated community surveillance
Tumor testing to identify lynch syndrome in two Australian colorectal cancer cohorts
Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma
Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH
Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn’s disease-related ileitis
Risk factors for metachronous colorectal cancer following a primary colorectal cancer: a prospective cohort study
Lack of evidence for germline RNF43 mutations in patients with serrated polyposis syndrome from a large multinational study
SNP rs16906252C>T is an expression and methylation quantitative trait locus associated with an increased risk of developing MGMT-methylated colorectal cancer
Multivitamin, calcium and folic acid supplements and the risk of colorectal cancer in Lynch syndrome
Adverse histological features in malignant colorectal polyps: a contemporary series of 239 cases
Germline mutations in PMS2 and MLH1 in individuals with solitary loss of PMS2 expression in colorectal carcinomas from the colon cancer family registry cohort
Serrated lesions of the appendix in serrated polyposis patients
Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome
Self-limited coeliac-like enteropathy: a series of 18 cases highlighting another coeliac disease mimic
A clinicopathological and molecular analysis of 200 traditional serrated adenomas
Do serrated neoplasms of the small intestine represent a distinct entity? Pathological findings and molecular alterations in a series of 13 cases
Rising incidence of early-onset colorectal cancer in Australia over two decades: report and review
Serrated tubulovillous adenoma of the large intestine
Association between molecular subtypes of colorectal cancer and patient survival
High prevalence of mismatch repair deficiency in prostate cancers diagnosed in mismatch repair gene mutation carriers from the colon cancer family registry
Clinical problems of colorectal cancer and endometrial cancer cases with unknown cause of tumor mismatch repair deficiency (suspected Lynch syndrome)
Should the grading of colorectal adenocarcinoma include microsatellite instability status?
Re: Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication
Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer
Tropical sprue: revisiting an underrecognized disease
Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer
Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives
Critical appraisal of the diagnosis of the sessile serrated adenoma
The challenging diagnosis of cronkhite-canada syndrome in the upper gastrointestinal tract: A series of 7 cases with clinical follow-up
Serrated colorectal polyps and polyposis
Detection of large scale 3' deletions in the PMS2 gene amongst Colon-CFR participants: have we been missing anything?
Association between hypermethylation of DNA repetitive elements in white blood cell DNA and early-onset colorectal cancer
Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features
Absence of PMS2 mutations in colon-CFR participants whose colorectal cancers demonstrate unexplained loss of MLH1 expression
PIK3CA Activating Mutation in Colorectal Carcinoma: Associations with Molecular Features and Survival
Germline Mutations in the Polyposis-Associated Genes BMPR1A, SMAD4, PTEN, MUTYH and GREM1 Are Not Common in Individuals with Serrated Polyposis Syndrome
Family history of colorectal cancer in BRAF p.V600E-mutated colorectal cancer cases
Multiplicity and molecular heterogeneity of colorectal carcinomas in individuals with serrated polyposis
Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management
Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome
Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype
BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for lynch syndrome
Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome
Gastrointestinal pathology in celiac disease: A case series of 150 consecutive newly diagnosed patients
Phenotype and polyp landscape in serrated polyposis syndrome: A series of 100 patients from genetics clinics
Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in Lynch syndrome mutation carriers: A case series from the Australasian site of the colon cancer family registry
Cancer risks for relatives of patients with serrated polyposis
Using tumour pathology to identify people at high genetic risk of breast and colorectal cancers
Colonic mucosubmucosal elongated polyp: A clinicopathologic study of 13 cases and review of the literature
Hyperplastic polyp of the duodenum: a report of 9 cases with immunohistochemical and molecular findings
Mutation deep within an intron of MSH2 causes Lynch syndrome
Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome)
Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas
Risk factors for colorectal cancer in patients with multiple serrated polyps: A cross-sectional case series from genetics clinics
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. (vol 131, pg 1096, 2006)
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression
MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors
KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome
Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma
Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans
Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation
Germline hepatocyte nuclear factor 1 alpha and 1 beta mutations in renal cell carcinomas
Identification of differentially expressed proteins in pancreatic cancer using a global proteomic approach
Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent
HER2 protein (p185(HER2)) is only rarely overexpressed in cervical cancer - The author replies
Mutation of TCF1 encoding hepatocyte nuclear factor 1 alpha in gynecological cancer
Analysis of correlation between mitotic index, MIB1 score and S-phase fraction as proliferation markers in invasive breast carcinoma. Methodological aspects and prognostic value in a series of 257 cases
Increased cell size and Akt activation in HER-2/neu-overexpressing invasive ductal carcinoma of the breast
Proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapy
Towards the identification of new markers of pancreatic cancer by gene expression analysis
Wide metastatic spreading in infiltrating lobular carcinoma of the breast
Heparin affin regulatory peptide in milk: Its involvement in mammary gland homeostasis
Overexpression/amplification of HER-2/neu is uncommon in invasive carcinoma of the uterine cervix
p16 inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays
Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: Phenotypic and genotypic analyses
Aberrant methylation of preproenkephalin and p16 genes in pancreatic Intraepithelial neoplasia and pancreatic ductal adenocarcinoma
Aberrant methylation of the 5 ' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanINs
Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology
Early detection of pancreatic carcinoma
Molecular pathogenesis of pancreatic cancer
Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE)
Discovery of new markers of cancer through serial analysis of gene expression: Prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma
Determination of microsatellite instability, p53 and K-ras mutations in hepatic metastases from patients with colorectal cancer: Relationship with response to 5-fluorouracil and survival
The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) - Results of an international collaborative study
Topoisomerase I-DNA covalent complexes in human colorectal cancer xenografts with different p53 and microsatellite instability status: Relation with their sensitivity to CTP-11
Association of a duodenal follicular lymphoma and hereditary nonpolyposis colorectal cancer
Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status
Endometrial stromal sarcoma with rhabdoid phenotype and sex cord-like areas
A voluminous inguinal hernia: dedifferentiated liposarcoma
Cytogenetic and molecular analysis of a t(1;22)(p36;q11.2) in a rhabdoid tumor with a putative homozygous deletion of chromosome 22

Conference Papers

A clinicopathological and molecular analysis of 107 sessile serrated adenomas with dysplasia
Tubulovillous adenoma with prominent architectural serration - a clinicopathological and molecular appraisal of a new subtype of colorectal polyp
Wnt signaling in an unselected series of colorectal carcinomas
Changing incidence of BRAF and KRAS mutations in colorectal carcinoma
Molecular subtypes of colorectal cancer in relation to disease survival
A clinicopathological and molecular appraisal of a large series of traditional serrated adenomas
Serrated Polyposis Syndrome: Monitored Colonoscopic Surveillance in a Tertiary Setting Is Safe
A Large Multi -Nation Serrated Polyposis Register: Role in Defining This Syndrome
Pathological and Clinical Features of Familial Colorectal Cancer Type X
PIK3CA Activating Mutation in Colorectal Carcinoma: A Stratified Analysis in a Prospective Cohort
Serrated Pathway Colorectal Carcinoma without Microsatellite Instability Demonstrates Aggressive Features and Is Associated with Poor Overall Survival
Prostate Carcinomas Arising in Lynch Syndrome Patients Frequently Show Concordant Mismatch Repair Deficiency
Serrated pathway colorectal carcinoma without microsatellite instability demonstrates Aggressive features and is associated with poor overall survival
Prostate carcinomas arising in Lynch Syndrome patients frequently show concordant mismatch repair deficiency
PIK3CA activating mutation in colorectal carcinoma: a stratified analysis in a prospective cohort
Family History and Pathology Features in Early-Onset Colorectal Cancer Cases With a BRAF P.V600e Mutation
Polyp Landscape in Serrated Polyposis Syndrome
The smoking paradox in high-risk serrated neoplasia patients
Origin of colorectal cancers in high-risk serrated neoplasia patients
Adenomas in lynch syndrome : Diagnostically useful?
Colonization of the metastatic site by circulating cells in a human colorectal cancer model: a neglected step in the metastatic process
Estrogen receptors evolution in neoadjuvant aromatase inhibitor (AI) therapy for breast cancer in elderly women - Stability of hormonal receptor expression during treatment
Neoadjuvant chemotherapy for invasive lobular carcinomas of the breast: a poorer response rate but not a worse prognosis than invasive ductal carcinoma
Prognostic and predictive value of proliferation markers to pathological response of T2-T4NON1 breast carcinomas treated with anthracycline-based preoperative chemotherapy
Aberrant methylation of ppENK in mucinous cystic neoplasms of the pancreas
Preproenkephalin and p16 gene CpG island hypermethylation in pancreatic intraepithelial neoplasia (PanIN) and invasive ductal adenocarcinoma
Among pancreatic adenocarcinomas treated by Whipple resection, an intact DPC4 portends a significantly improved patient survival.
Clonal P53 mutated patches in normal sun exposed skin do not predispose to multiple skin carcinomas
Molecular cytogenetic studies on rhabdoid tumors