Professor David Craik
ARC Laureate Fellow - Group Leader
Institute for Molecular Bioscience
Affiliated Professor
School of Biomedical Sciences
+61 7 334 62019
Researcher biography
David Craik is in the Division of Chemistry and Structural Biology at the Institute for Molecular Bioscience, The University of Queensland, Australia. He discovered the cyclotide family of circular proteins and has characterized the structures of many animal toxins including conotoxins from cone snail venoms. He heads a research team of 35 researchers whose current work focuses on applications of circular proteins, toxins and NMR in drug design.
He is author of over 600 scientific papers, including 6 in Nature/Nature Communications/Nature Neoroscience/Nature Structural Biology/Nature Chemical Biology/Nature Chemistry, 1 in Science, 9 in PNAS and 8 in Angewandte Chemie. He is a Fellow of the Australian Academy of Science and has received numerous awards for his research, including the Ralph F. Hirschmann Award from the American Chemical Society (2011), Ramaciotti Medal for Excellence in Biomedical Research (2014), GlaxoSmithKline Award for Research Excellence (2014), the Vincent du Vigneaud Award from the American Peptide Society (2015) and the FAOBMB Award for Research Excellence (2015). He is an Honorary Professor of Jinan University, Guangzhou and has an Honorary Doctorate from Kalmar University in Sweden.
Biography
David Craik obtained his PhD in organic chemistry from La Trobe University in Melbourne, Australia and undertook postdoctoral studies at Florida State and Syracuse Universities before taking up a lectureship at the Victorian College of Pharmacy in 1983. He was appointed Professor of Medicinal Chemistry and Head of School in 1988. He moved to University of Queensland in 1995 to set up a new biomolecular NMR laboratory and is currently an Australian Research Council Laureate Fellow.
Key Discoveries
David Craik has made discoveries of new classes of proteins, generated new knowledge on their structure and function, and used this information to design and chemically re-engineer new classes of protein-based drug leads and agricultural pest control agents. In particular, his major achievements are:
- the discovery of cyclotides, the largest known family of circular proteins. As well as a circular backbone, cyclotides contain a knotted arrangement of cross-linking disulfide bonds, making them remarkably stable. His discovery of these proteins was sparked in part from anecdotal reports of medicinal practices in Africa where women make a tea from the plant Oldenlandia affinis by boiling it in water and sipping it during labour to accelerate child birth. He determined the structure of the bioactive component of this medicinal tea and found that it had an unprecedented head-to-tail cyclic peptide backbone combined with a cystine knot.
- the first structural and functional characterizations of prototypic circular proteins in higher organisms - Professor Craik was one of the first to recognize that other families of ribosomally synthesized cyclic peptides exist. As examples from bacteria and animals emerged, Professor Craik was at the forefront of their structural characterization, reporting the first structures of theta-defensins from animals and the threaded lasso peptide microcin J25 from bacteria, as well as new examples of cyclic peptides from plants.
- the development of artificially cyclized peptide toxins as drug leads – he developed an orally active peptide that is 100 times more potent than the leading clinically used drug for neuropathic pain.
Research Training
Professor Craik has trained more than 60 PhD students. He was awarded UQ's Research Supervision Excellence Award in 2007 on the basis of his mentoring and innovations in postgraduate training, including his "writing retreats" to mentor students and postdocs on science writing skills. He was awarded an honorary doctorate from Kalmar University, Sweden for his contributions to international student exchange programs.
Professional Activities
Professor Craik founded and chaired the 1st, 2nd and 3rd International Conferences on Circular Proteins (2009, 2012 and 2015). He is on the Boards of nine international journals and on the Council of the American Peptide Society. He is the director two Brisbane-based biotech companies. He is on the Scientific Advisory Boards of James Cook University's Centre for Biodiscovery and Molecular Development of Therapeutics (BMDT) and the University of Wollongong's Illawara Health and Medical Research Institute (IHMRI). He conceived and supports a publicly accessible database Cybase on circular proteins (www.cybase.org.au) and another database on conotoxins (www.conoserver.org).
Publications
Book Chapters
Schirra, Horst Joachim and Craik, David J. (2019).Overview of NMR in the Pharmaceutical Sciences. Modern Magnetic Resonance. (pp. 1195-1202) edited by .Dordrecht, Netherlands: Springer Netherlands. doi:10.1007/1-4020-3910-7_128
Agwa, Akello J., Craik, David J. and Schroeder, Christina I. (2019).Cyclizing disulfide-rich peptides using sortase A. Methods in Molecular Biology. (pp. 29-41) edited by Timo Nuijens and Marcel Schmidt.New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-9546-2_3
Craik, David J. and Peacock, Hayden (2018).Overview of NMR in drug design. Modern Magnetic Resonance. (pp. 1971-1981) edited by .Cham, Switzerland: Springer International Publishing. doi:10.1007/978-3-319-28388-3_112
Oguis, Georgianna Kae, Kan, Meng-Wei and Craik, David J. (2017).Cyclotides: plant defense toxins. Plant toxins. (pp. 221-242) edited by P. Gopalakrishnakone, Célia Regina Carlini and Rodrigo Ligabue-Braun.Dordrecht, Netherlands: Springer. doi:10.1007/978-94-007-6464-4_7
Oguis, Georgianna Kae, Kan, Meng-Wei and Craik, David J. (2017).Cyclotides: plant defense toxins. Plant toxins. (pp. 221-243) edited by P Gopalakrishnakone, Célia R Carlini and Rodrigo Ligabue-Braun.Dordrecht, The Netherlands: Springer, Dordrecht. doi:10.1007/978-94-007-6464-4
Craik, David J., Kaas, Quentin and Wang, Conan K. (2017).A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling). Practical medicinal chemistry with macrocycles: Design, synthesis, and case studies. (pp. 25-57) edited by Eric Marsault and Mark L Peterson.Hoboken, New Jersey, United States: John Wiley & Sons. doi:10.1002/9781119092599.ch2
de Veer, Simon J. and Craik, David J. (2017).Naturally occurring disulfide-rich cyclic peptides from plants and animals: Synthesis and biosynthesis. Chemical biology of natural products. (pp. 491-529) edited by David J. Newman, Gordon M. Cragg and Paul Grothaus.Boca Raton, FL United States: CRC Press. doi:10.1201/9781315117089-14
Craik, David J. and Peacock, Hayden (2017).Overview of NMR in drug design. Modern magnetic resonance. (pp. 1-11) edited by Graham A. Webb.Cham, Switzerland: Springer International Publishing. doi:10.1007/978-3-319-28275-6_112-1
Akcan, Muharrem and Craik, David J. (2015).Engineering venom peptides to improve their stability and bioavailability. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. (pp. 275-289) edited by Glenn F. King.Cambridge, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849737876-00275
Henriques, Sonia Troeira and Craik, David J. (2015).Discovery of peptide drugs from natural sources. Peptide chemistry and drug design. (pp. 203-245) edited by Ben M. Dunn.Hoboken NJ, United States: John Wiley & Sons. doi:10.1002/9781118995303.ch6
Northfield, Susan E., Poth, Aaron, D'Souza, Charlotte and Craik, David J. (2014).Cyclotide analysis. Encyclopedia of Analytical Chemistry. (pp. 1-18) edited by Robert A. Meyers.Hoboken, NJ, USA: John Wiley & Sons. doi:10.1002/9780470027318.a9933
Kaas, Quentin and Craik, David J. (2014).Conotoxins and other conopeptides. Outstanding Marine Molecules: Chemistry, Biology, Analysis. (pp. 319-332) edited by Stéphane La Barre and Jean-Michel Kornprobst.Weinheim, Germany: Wiley-VCH Verlag. doi:10.1002/9783527681501.ch14
Akcan, Muharrem and Craik, David J. (2013).Synthesis of cyclic disulfide-rich peptides. Peptide synthesis and applications. (pp. 89-101) edited by Knud J. Jensen, Pernille Tofteng Shelton and Soren L. Pedersen.New York, NY, United States: Springer. doi:10.1007/978-1-62703-544-6_6
Craik, David J., Henriques, Sonia Troeira, Mylne, Joshua S. and Wang, Conan K. (2012).Cyclotide isolation and characterization. Natural product biosynthesis by microorganisms and plants, part B. (pp. 37-62) edited by David A. Hopwood.Burlington, USA: Elsevier. doi:10.1016/B978-0-12-394291-3.00024-1
Daly, Norelle L., Gruber, Christian W., Goransson, Ulf and Craik, David J. (2011).Cystine knot folding in cyclotides. Folding of disulfide proteins. (pp. 43-61) edited by Chang, RJY and Ventura, S.New York , NY, U.S.A.: Springer. doi:10.1007/978-1-4419-7273-6
Akcan, Muharrem and Craik, David J. (2011).Conotoxin-based leads in drug design. Peptide drug discovery and development: Translational research in academia and industry. (pp. 119-137) edited by Miguel Castanho and Nuno C. Santos.Weinheim, Germany: Wiley-VCH. doi:10.1002/9783527636730.ch5
Jan Westermann and Craik, David J. (2010).Plant peptide toxins from nonmarine environments. Comprehensive natural products II: Chemistry and biology. (pp. 257-285) edited by Mander, Lewis and Liu, Hung-Wen.Oxford,U.K.: Elsevier Science. doi:10.1016/B978-008045382-8.00115-5
Dornenburg, Heike and Craik, David J. (2010).Cyclotides. Encyclopedia of industrial biotechnology: Bioprocess, bioseparation, and cell technology. (pp. 1849-1866) edited by Michael C. Flickinger.Hoboken, NJ United States: Wiley. doi:10.1002/9780470054581.eib250
Craik, David J., Smith, Philippa A. and Clark, Richard James (2010).NMR-based screening and drug discovery. Burger's medicinal chemistry, drug discovery, and development. (pp. 359-437) edited by Donald J. Abraham, David P. Rotella and Alfred Burger.Hoboken, N.J.: Wiley. doi:10.1002/0471266949
Kaas, Quentin, Westermann, Jan-Christoph, Troeira Henriques, Sonia and Craik, David J. (2010).Antimicrobial Peptides in Plants. Antimicrobial Peptides: Discovery, Design, and Novel Therapeutic Strategies. (pp. 40-71) edited by Guangshun Wang.Wallingford, Oxfordshire, UK: CAB International. doi:10.1079/9781845936570.0040
Wang, Conan K., Huang, Yen-Hua, Greenwood, Kathryn and Craik, David J. (2010).Membrane binding of cyclotides. Membrane-active peptides: Methods and results on structure and function. (pp. 597-672) edited by Miguel A.R.B. Castanho.La Jolla, CA, U.S.A.: International University Line.
Rosengren, K. Johan, Daly, N. L. and Craik, D. J. (2009).NMR of peptide toxins. Annual reports on NMR Spectroscopy. (pp. 89-147) edited by Graham A. Webb.Oxford England U.K.: Academic Press Elsevier. doi:10.1016/S0066-4103(09)06802-1
Daly, N. L. and Craik, D. J. (2009).Folding motifs of cystine-rich peptides. Oxidative folding of peptides and proteins. (pp. 318-344) edited by Johannes Buchner and Luis Moroder.Cambridge, UK: Royal Society of Chemistry.
Jan Westermann and Craik, David J. (2008).NMR in peptide drug development. Peptide-Based Drug Design (Methods in Molecular Biology). (pp. 87-113) edited by Laszlo Otvos.New York: Humana Press. doi:10.1007/978-1-59745-419-3
Craik, D. J. and Clark, R. J. (2008).Structure-based Drug Design and NMR-based screening. Pharmacology from drug development to gene therapy. (pp. 225-313) edited by R. A. Meyers.Weinheim: Wiley-VCH Verlag GMBH & Co.
Cemazar, M. and Craik, D. J. (2006).NMR and Structural Genomics in the Pharmaceutical Sciences. Modern Magnetic Resonance Part 2: Applications in Medical and Pharmaceutical Sciences. (pp. 1411-1419) edited by Graham A. Webb.Netherlands: Springer.
Schirra, H. J. and Craik, D. J. (2006).Overview of NMR in the Pharmaceutical Sciences. Modern Magnetic Resonance Part 2: Applications in Medical and Pharmaceutical Sciences. (pp. 1177-1184) edited by Graham A. Webb.Netherlands: Springer.
Craik, D. J. and Clark, R. J. (2005).Structure-based drug design and NMR-based screening. Encyclopdeia of Molecular Cell Biology and Molecular Medicine. (pp. 517-605) edited by Robert A Meyers.Germany: Wiley-VCH.
Craik, D. J. and Clark, R. J. (2003).NMR and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery, Vol 1, Drug Discovery. (pp. 507-582) edited by Donald J Abraham.USA: John Wiley & Sons.
Craik, D. J. and Scanlon, M. J. (2000).Marine toxins as a starting point for drugs. Seafood and Freshwater Toxins Pharmacology, Physiology and Dection. (pp. 715-740) edited by Luis M Botana.New York: Marcel Dekker Inc.
Craik, D. J. and Scanlon, M. J. (2000).Pharmaceutical Applications of NMR. Annual Reports on NMR Spectroscopy. (pp. 115-174) edited by Webb and GA.USA: Academic Press.
Journal Articles
Dang, Tien T., Chan, Lai Y., Huang, Yen-Hua, Nguyen, Linh T. T., Kaas, Quentin, Huynh, Tien and Craik, David J. (2020). Exploring the sequence diversity of cyclotides from Vietnamese Viola species. Journal of Natural Products, 83 (6) acs.jnatprod.9b01218, 1817-1828. doi:10.1021/acs.jnatprod.9b01218
Israel, Mathilde R., Dash, Thomas S., Bothe, Stefanie N., Robinson, Samuel D., Deuis, Jennifer R., Craik, David J., Lampert, Angelika, Vetter, Irina and Durek, Thomas (2020). Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe. Biomedicines, 8 (6) doi:10.3390/biomedicines8060155
White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020) Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides. Angewandte Chemie International Edition, .doi:10.1002/anie.202003435
Du, Qingdan, Chan, Lai Y., Gilding, Edward K., Henriques, Sónia Troeira, Condon, Nicholas D., Ravipati, Anjaneya S., Kaas, Quentin, Huang, Yen-Hua and Craik, David J. (2020). Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. Journal of Biological Chemistry doi:10.1074/jbc.ra120.012627
Yin, Huawu, Huang, Yen-Hua, Deprey, Kirsten, Condon, Nicholas D., Kritzer, Joshua A., Craik, David J. and Wang, Conan K. (2020). Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffold. ACS Chemical Biology, 15 (6) acschembio.0c00297, 1650-1661. doi:10.1021/acschembio.0c00297
Georgianna Oguis, Edward Gilding, Yen-Hua Huang, Aaron Poth, Mark Jackson and Craik, David J. (2020) Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions. Industrial Crops and Products, 147 112214.doi:10.1016/j.indcrop.2020.112214
Agwa, Akello J., Tran, Poanna, Mueller, Alexander, Tran, Hue N. T., Deuis, Jennifer R., Israel, Mathilde R., McMahon, Kirsten L., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2020) Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. The Journal of Biological Chemistry, 295 15: 5067-5080. doi:10.1074/jbc.ra119.012281
Du, Junqiao, Kuok Yap, Angeline (Lai Yue) Chan, Rehm, Fabian, Fong Looi, Aaron Poth, Edward Gilding, Kaas, Quentin, Durek, Thomas and Craik, David J. (2020) A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors. Nature Communications, 11 1: 1-11.doi:10.1038/s41467-020-15418-2
Kan, Meng-Wei and Craik, David J. (2020). Discovery of cyclotides from Australasian plants. Australian Journal of Chemistry, 73 (4) 287-299. doi:10.1071/ch19658
Smithies, Bronwyn J., Huang, Yen-Hua, Jackson, Mark A., Yap, Kuok, Gilding, Edward K., Harris, Karen S., Anderson, Marilyn A. and Craik, David J. (2020) Circular permutation of the native enzyme-mediated cyclization position in cyclotides. ACS Chemical Biology, 15 4: 962-969.doi:10.1021/acschembio.9b00996
Tombling, Benjamin J., Wang, Conan K. and Craik, David J. (2020) EGF‐artige und andere disulfidreiche Mikrodomänen als therapeutische Molekülgerüste. Angewandte Chemie, . doi:10.1002/ange.201913809
Turner, Ashlin, Kaas, Quentin, Craik, David J. and Schroeder, Christina Ingrid (2020) Early development of Monoplex pilearis and Monoplex parthenopeus (Gastropoda: Cymatiidae): biology and morphology. Organisms Diversity & Evolution, 20 1: 51-62.doi:10.1007/s13127-020-00432-5
Yu, Rilei, Wang, Jiayi, So, Lok-Yan, Peta Harvey, Shi, Juan, Liang, Jiazhen, Dou, Qin, Li, Xiao, Yan, Xiayi, Yen-Hua Huang, Xu, Qingliang, Kaas, Quentin, Chow, Ho-Yin, Wong, Kwok-Yin, Craik, David J., Zhang, Xiaohua, Jiang, Tao and Wang, Yan (2020) Enhanced activity against multi-drug resistant bacteria through coapplication of an analogue of Tachyplesin I and an inhibitor of the QseC/B signaling pathway. Journal of Medicinal Chemistry, 63 7: 3475-3484.doi:10.1021/acs.jmedchem.9b01563
Xu, Pan, Kaas, Quentin, Wu, Yong, Zhu, Xiaopeng, Li, Xincan, Peta Harvey, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2020) Structure and activity studies of disulfide-deficient analogues of αO-conotoxin GeXIVA. Journal of Medicinal Chemistry, 63 4: 1564-1575.doi:10.1021/acs.jmedchem.9b01409
Hansen, Ida K. Ø., Isaksson, Johan, Aaron Poth, Hansen, Kine Ø., Andersen, Aaron J. C., Richard, Céline S. M., Blencke, Hans-Matti, Stensvåg, Klara, Craik, David J. and Haug, Tor (2020) Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens. Marine Drugs, 18 1: 1-20.doi:10.3390/md18010051
Li, Choi Yi, Yap, Kuok, Swedberg, Joakim E., Craik, David J. and de Veer, Simon J. (2020). Binding loop substitutions in the cyclic peptide SFTI-1 generate potent and selective chymase inhibitors. Journal of Medicinal Chemistry, 63 (2) acs.jmedchem.9b01811, 816-826. doi:10.1021/acs.jmedchem.9b01811
Tombling, Benjamin J., Wang, Conan K. and Craik, David J. (2019). EGF-like and other disulfide-rich microdomains as therapeutic scaffolds. Angewandte Chemie International Edition doi:10.1002/anie.201913809
Vernen, Felicitas, Craik, David J., Lawrence, Nicole and Troeira Henriques, Sónia (2019). Cyclic analogues of horseshoe crab peptide Tachyplesin I with anticancer and cell penetrating properties. ACS Chemical Biology, 14 (12) 2895-2908. doi:10.1021/acschembio.9b00782
de Veer, Simon J., Kan, Meng-Wei and Craik, David J. (2019) Cyclotides: from structure to function. Chemical Reviews, 119 24: 12375-12421. doi:10.1021/acs.chemrev.9b00402
Bleackley, Mark R., Dawson, Charlotte S., Payne, Jennifer A.E., Harvey, Peta J., Rosengren, K. Johan, Quimbar, Pedro, Garcia-Ceron, Donovan, Lowe, Rohan, Bulone, Vincent, van der Weerden, Nicole L, Craik, David J. and Anderson, Marilyn A. (2019). The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins. The Cell Surface, 5100026, doi:10.1016/j.tcsw.2019.100026
Troeira Henriques, Sónia, Peacock, Hayden, Benfield, Aurelie, Wang, Conan K and Craik, David J (2019) Is the mirror image a true reflection? Intrinsic membrane chirality modulates peptide binding. Journal of the American Chemical Society, 141 51: 20460-20469. doi:10.1021/jacs.9b11194
Huang, Yen-Hua, Du, Qingdan and Craik, David J. (2019). Cyclotides: disulfide-rich peptide toxins in plants. Toxicon, 17233-44. doi:10.1016/j.toxicon.2019.10.244
Rehm, Fabian B. H., Harmand, Thibault J., Yap, Kuok, Durek, Thomas, Craik, David J. and Ploegh, Hidde L. (2019). Site-specific sequential protein labeling catalyzed by a single recombinant ligase. Journal of the American Chemical Society, 141 (43) jacs.9b09166, 17388-17393. doi:10.1021/jacs.9b09166
Jin, Ai-Hua, Muttenthaler, Markus, Dutertre, Sebastien, Himaya, S.W.A., Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2019) Conotoxins: chemistry and biology. Chemical Reviews, . doi:10.1021/acs.chemrev.9b00207
Sang, Jianrong, Kulkarni, Ketav, Watson, Gabrielle M., Ma, Xiuquan, Craik, David J., Henriques, Sónia T., Poth, Aaron G., Benfield, Aurélie H. and Wilce, Jacqueline A. (2019) Evaluation of cyclic peptide inhibitors of the Grb7 breast cancer target: small change in cargo results in large change in cellular activity. Molecules, 24 20: 3739. doi:10.3390/molecules24203739
Ma, He, Qiu, Peiju, Harvey, Peta J., Li, Xiao, Zhang, Zheyu, Xu, Qingliang, Liang, Jiazhen, Kaas, Quentin, Craik, David J., Yang, Jinbo, Jiang, Tao, Bi, Xiaolin and Yu, Rilei (2019). In Silico design of MDM2-targeting peptides from a naturally occurring constrained peptide. Chemmedchem, 14 (19) cmdc.201900366, 1710-1716. doi:10.1002/cmdc.201900366
Oshiro, Karen G. N., Cândido, Elizabete S., Chan, Lai Y., Torres, Marcelo D. T., Monges, Bruna E. D., Rodrigues, Silvia G., Porto, William F., Ribeiro, Suzana M., Henriques, Sónia T., Lu, Timothy K., de la Fuente-Nunez, Cesar, Craik, David J., Franco, Octávio L. and Cardoso, Marlon H. (2019). Computer-aided design of mastoparan-like peptides enables the generation of nontoxic variants with extended antibacterial properties. Journal of Medicinal Chemistry, 62 (17) 8140-8151. doi:10.1021/acs.jmedchem.9b00915
Vernen, Felicitas, Harvey, Peta J., Dias, Susana A., Veiga, Ana Salomé, Huang, Yen-Hua, Craik, David J., Lawrence, Nicole and Troeira Henriques, Sónia (2019). Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties. International Journal of Molecular Sciences, 20 (17) 4184, doi:10.3390/ijms20174184
Philippe, Grégoire J. -B., Gaspar, Diana, Sheng, Caibin, Huang, Yen-Hua, Benfield, Aurélie H., Condon, Nicholas D., Weidmann, Joachim, Lawrence, Nicole, Löwer, Alexander, Castanho, Miguel A. R. B., Craik, David J. and Troeira Henriques, Sónia (2019). Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties. ACS Chemical Biology, 14 (9) 2071-2087. doi:10.1021/acschembio.9b00593
Harris, Karen S., Guarino, Rosemary F., Dissanayake, Ravindu S., Quimbar, Pedro, McCorkelle, Owen C., Poon, Simon, Kaas, Quentin, Durek, Thomas, Gilding, Edward K., Jackson, Mark A., Craik, David J., van der Weerden, Nicole L., Anders, Robin F. and Anderson, Marilyn A. (2019) A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein. Scientific Reports, 9 1: . doi:10.1038/s41598-019-47273-7
Tian, Sixin, Swedberg, Joakim E., Li, Choi Yi, Craik, David J. and de Veer, Simon J. (2019). Iterative optimization of the cyclic peptide SFTI-1 yields potent inhibitors of neutrophil proteinase 3. ACS Medicinal Chemistry Letters, 10 (8) acsmedchemlett.9b00253, 1234-1239. doi:10.1021/acsmedchemlett.9b00253
Cândido, Elizabete S., Cardoso, Marlon H., Chan, Lai Y., Torres, Marcelo D. T., Oshiro, Karen G. N., Porto, William F., Ribeiro, Suzana M., Haney, Evan F., Hancock, Robert E. W., Lu, Timothy K., de la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octávio L. (2019). Short cationic peptide derived from archaea with dual antibacterial properties and anti-infective potential. ACS Infectious Diseases, 5 (7) acsinfecdis.9b00073, 1081-1086. doi:10.1021/acsinfecdis.9b00073
Koehbach, Johannes and Craik, David J. (2019). The vast structural diversity of antimicrobial peptides. Trends in Pharmacological Sciences, 40 (7) 517-528. doi:10.1016/j.tips.2019.04.012
Poth, Aaron G., Huang, Yen-Hua, Le, Thao T., Kan, Meng-Wei and Craik, David J. (2019). Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold. International Journal of Pharmaceutics, 565437-446. doi:10.1016/j.ijpharm.2019.05.001
Schmidt, Marcel, Huang, Yen-Hua, de Oliveira, Eduardo F. Texeira, Toplak, Ana, Wijma, Hein J., Janssen, Dick B., van Maarseveen, Jan H., Craik, David J. and Nuijens, Timo (2019) Efficient enzymatic cyclization of disulfide-rich peptides by using peptide ligases. ChemBioChem, 20 12: 1524-1529. doi:10.1002/cbic.201900033
Yin, Huawu, Craik, David J. and Wang, Conan K. (2019) Anchor residues guide form and function in grafted peptides. Angewandte Chemie International Edition, 58 23: 7652-7656. doi:10.1002/anie.201901572
Chambers, Chris, Cutler, Penny, Huang, Yen-Hua, Goodchild, James A., Blythe, Judith, Wang, Conan K., Bigot, Aurélien, Kaas, Quentin, Craik, David J., Sabbadin, Davide and Earley, Fergus G. (2019). Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. FEBS Letters, 593 (12) 1873-3468.13435, 1336-1350. doi:10.1002/1873-3468.13435
Yin, Huawu, Craik, David J. and Wang, Conan K. (2019). Anchor residues guide form and function in grafted peptides. Angewandte Chemie, 131 (23) 7734-7738. doi:10.1002/ange.201901572
Nicolas, Sebastien, Zoukimian, Claude, Bosmans, Frank, Montnach, Jerome, Diochot, Sylvie, Cuypers, Eva, De Waard, Stephan, Beroud, Remy, Mebs, Dietrich, Craik, David, Boturyn, Didier, Lazdunski, Michel, Tytgat, Jan and De Waard, Michel (2019). Chemical synthesis, proper folding, Na-v channel selectivity profile and analgesic properties of the spider peptide phlotoxin 1. Toxins, 11 (6) 367, doi:10.3390/toxins11060367
El Hamdaoui, Yamina, Wu, Xiaosa, Clark, Richard J., Giribaldi, Julien, Anangi, Raveendra, Craik, David J., King, Glenn F., Dutertre, Sebastien, Kaas, Quentin, Herzig, Volker and Nicke, Annette (2019). Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR. Frontiers in Pharmacology, 10 (MAY) 577, doi:10.3389/fphar.2019.00577
Oguis, Georgianna K., Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2019) Butterfly pea (Clitoria ternatea), a cyclotide-bearing plant with applications in agriculture and medicine. Frontiers in Plant Science, 10 645. doi:10.3389/fpls.2019.00645
Jackson, Mark A., Yap, Kuok, Poth, Aaron G., Gilding, Edward K., Swedberg, Joakim E., Poon, Simon, Qu, Haiou, Durek, Thomas, Harris, Karen, Anderson, Marilyn A. and Craik, David J. (2019). Rapid and scalable plant-based production of a potent plasmin inhibitor peptide. Frontiers in Plant Science, 10602, doi:10.3389/fpls.2019.00602
Israel, Mathilde R., Tanaka, Brian S., Castro, Joel, Thongyoo, Panumart, Robinson, Samuel D., Zhao, Peng, Deuis, Jennifer R., Craik, David J., Durek, Thomas, Brierley, Stuart M., Waxman, Stephen G, Dib-Hajj, Sulayman D. and Vetter, Irina (2019). NaV1.6 regulates excitability of mechanosensitive sensory neurons. Journal of Physiology, 597 (14) 3751-3768. doi:10.1113/JP278148
Yu, Rilei, Tae, Han‐Shen, Xu, Qingliang, Craik, David J., Adams, David J., Jiang, Tao and Kaas, Quentin (2019). Molecular dynamics simulations of dihydro‐β‐erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. British Journal of Pharmacology, 176 (15) bph.14698, 2750-2763. doi:10.1111/bph.14698
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Rehm, Fabian B. H., Jackson, Mark A., De Geyter, Ewout, Yap, Kuok, Gilding, Edward K., Durek, Thomas and Craik, David J. (2019) Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization. Proceedings of the National Academy of Sciences, 116 16: 7831-7836. doi:10.1073/pnas.1901807116
Li, Choi Yi, de Veer, Simon J., White, Andrew M., Chen, Xingchen, Harris, Jonathan M., Swedberg, Joakim E. and Craik, David J. (2019). Amino acid scanning at P5′ within the Bowman–Birk inhibitory loop reveals specificity trends for diverse serine proteases. Journal of Medicinal Chemistry, 62 (7) acs.jmedchem.9b00211, 3696-3706. doi:10.1021/acs.jmedchem.9b00211
Wang, Conan K. and Craik, David J. (2019). Toward structure determination of disulfide-rich peptides using chemical shift-based methods. The Journal of Physical Chemistry B, 123 (9) acs.jpcb.8b10649, 1903-1912. doi:10.1021/acs.jpcb.8b10649
Peigneur, Steve, Cheneval, Olivier, Maiti, Mohitosh, Leipold, Enrico, Heinemann, Stefan H., Lescrinier, Eveline, Herdewijn, Piet, De Lima, Maria Elena, Craik, David J., Schroeder, Christina I. and Tytgat, Jan (2019). Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. FASEB Journal, 33 (3) 3693-3703. doi:10.1096/fj.201801909R
Dash, Thomas S., Shafee, Thomas, Harvey, Peta J., Zhang, Chuchu, Peigneur, Steve, Deuis, Jennifer R., Vetter, Irina, Tytgat, Jan, Anderson, Marilyn A., Craik, David J., Durek, Thomas and Undheim, Eivind A. B. (2019) A centipede toxin family defines an ancient class of CSαβ defensins. Structure, 27 2: 315-326. doi:10.1016/j.str.2018.10.022
Swedberg, Joakim E., Wu, Guojie, Mahatmanto, Tunjung, Durek, Thomas, Caradoc-Davies, Tom T., Whisstock, James C., Law, Ruby H. P. and Craik, David J. (2019). Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold attenuate fibrinolysis in plasma. Journal of Medicinal Chemistry, 62 (2) acs.jmedchem.8b01139, 552-560. doi:10.1021/acs.jmedchem.8b01139
Du, Junqiao, Chan, Lai Yue, Poth, Aaron G. and Craik, David J. (2019). Discovery and characterization of cyclic and acyclic trypsin inhibitors from Momordica dioica. Journal of Natural Products, 82 (2) acs.jnatprod.8b00716, 293-300. doi:10.1021/acs.jnatprod.8b00716
Silva, Osmar N., Pinto, Michelle F. S., Viana, Juliane F. C., Freitas, Camila G., Fensterseifer, Isabel C. M., Craik, David J. and Franco, Octavio L. (2019) Evaluation of the in vitro antitumor activity of nanostructured cyclotides in polymers of Eudragit (R) L 100-55 and RS 30 D. Letters in Drug Design and Discovery, 16 4: 437-445. doi:10.2174/1570180815666180801115526
Swedberg, Joakim E., Ghani, Hafiza Abdul, Harris, Jonathan M., de Veer, Simon J. and Craik, David J. (2018) Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II. ACS Medicinal Chemistry Letters, 9 12: 1258-1262. doi:10.1021/acsmedchemlett.8b00422
Lawrence, Nicole, Wu, Bin, Ligutti, Joseph, Cheneval, Olivier, Agwa, Akello Joanna, Benfield, Aurélie H., Biswas, Kaustav, Craik, David J., Miranda, Les P., Henriques, Sónia Troeira and Schroeder, Christina I. (2018) Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. ACS Chemical Biology, . doi:10.1021/acschembio.8b00989
Ramalho, Suelem D., Wang, Conan K., King, Gordon J., Byriel, Karl A., Huang, Yen-Hua, Bolzani, Vanderlan S. and Craik, David J. (2018). Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species. Journal of Natural Products, 81 (11) acs.jnatprod.8b00447, 2436-2445. doi:10.1021/acs.jnatprod.8b00447
Niyomploy, Ploypat, Chan, Lai Yue, Harvey, Peta J., Poth, Aaron G., Colgrave, Michelle L. and Craik, David J. (2018) Discovery and characterization of cyclotides from Rinorea species. Journal of Natural Products, 81 11: 2512-2520. doi:10.1021/acs.jnatprod.8b00572
Yu, Jinpeng, Zhu, Xiaopeng, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2018) Single amino acid substitution in α-conotoxin TxID reveals a specific α3β4 nicotinic acetylcholine receptor antagonist. Journal of Medicinal Chemistry, 61 20: 9256-9265. doi:10.1021/acs.jmedchem.8b00967
Harvey, Peta J., Kurniawan, Nyoman D., Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Van Lysebetten, Dorien, Dash, Thomas S., Hill, Justine M., Adams, David J., Durek, Thomas and Craik, David J. (2018). NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency. Molecules, 23 (10) molecules23102715, doi:10.3390/molecules23102715
Cardoso, Marlon, Cândido, Elizabete, Chan, Lai, Torres, Marcelo Der Torossian, Oshiro, Karen, Rezende, Samilla, Porto, William F., Lu, Timothy K., de la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octávio L. (2018). A computationally designed peptide derived from Escherichia coli as a potential drug template for antibacterial and antibiofilm therapies. ACS Infectious Diseases, 4 (12) acsinfecdis.8b00219, 1727-1736. doi:10.1021/acsinfecdis.8b00219
Kwon, Soohyun, Duarte, Joao N., Li, Zeyang, Ling, Jingjing J., Cheneval, Olivier, Durek, Thomas, Schroeder, Christina I., Craik, David J. and Ploegh, Hidde L. (2018) Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chemical Biology, 13 10: 2973-2980. doi:10.1021/acschembio.8b00653
Agwa, Akello J., Blomster, Linda V., Craik, David J., King, Glenn F. and Schroeder, Christina I. (2018). Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry, 29 (10) acs.bioconjchem.8b00505, 3309-3319. doi:10.1021/acs.bioconjchem.8b00505
Hone, Arik J., Talley, Todd T, Bobango, Janet, Huidobro Melo, Cesar, Hararah, Fuaad, Gajewiak, Joanna B., Christensen, Sean B, Harvey, Peta J., Craik, David J. and McIntosh, J. Michael (2018) Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 293 46: 17838-17852. doi:10.1074/jbc.ra118.005649
Li, Choi Yi, de Veer, Simon J., Law, Ruby H. P., Whisstock, James C., Craik, David J. and Swedberg, Joakim E. (2018). Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library. ChemBioChem, 19 (1) 46-50. doi:10.1002/cbic.201800395
Wu, Xiaosa, Tae, Han-Shen, Huang, Yen-Hua, Adams, David J., Craik, David J. and Kaas, Quentin (2018). Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology, 155288-297. doi:10.1016/j.bcp.2018.07.007
de Veer, Simon J., Li, Choi Yi, Swedberg, Joakim E., Schroeder, Christina I. and Craik, David J. (2018). Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. European Journal of Medicinal Chemistry, 155695-704. doi:10.1016/j.ejmech.2018.06.029
Lawrence, Nicole, Dennis, Adelaide S. M., Lehane, Adele M., Ehmann, Anna, Harvey, Peta J., Benfield, Aurélie H., Cheneval, Olivier, Henriques, Sónia Troeira, Craik, David J. and McMorran, Brendan J. (2018). Defense peptides engineered from human platelet factor 4 kill Plasmodium by selective membrane disruption. Cell Chemical Biology, 25 (9) 1140-+. doi:10.1016/j.chembiol.2018.06.009
Jackson, M. A., Gilding, E. K., Shafee, T., Harris, K. S., Kaas, Q., Poon, S., Yap, K., Jia, H., Guarino, R., Chan, L. Y., Durek, T., Anderson, M. A. and Craik, D. J. (2018). Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases. Nature Communications, 9 (1) 2411, doi:10.1038/s41467-018-04669-9
Wang, Conan K., Ghani, Hafiza Abdul, Bundock, Anna, Weidmann, Joachim, Harvey, Peta J., Edwards, Ingrid A., Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2018). Calcium-mediated allostery of the EGF fold. ACS Chemical Biology, 13 (6) 1659-1667. doi:10.1021/acschembio.8b00291
Sadeghi, Mahsa, Carstens, Bodil B., Callaghan, Brid P., Daniel, James T., Tae, Han Shen, O'Donnell, Tracey, Castro, Joel, Brierley, Stuart M., Adams, David J., Craik, David J. and Clark, Richard J. (2018) Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1. ACS Chemical Biology, 13 6: 1577-1587. doi:10.1021/acschembio.8b00190
Craik, David J. and Payne, Richard J. (2018). Emerging peptide science in Australia. Peptide Science, 110 (3) e24080, doi:10.1002/pep2.24080
Agwa, Akello J., Peigneur, Steve, Chow, Chun Yuen, Lawrence, Nicole, Craik, David J., Tytgat, Jan, King, Glenn F., Henriques, Sonia Troeira and Schroeder, Christina I. (2018). Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes. Journal of Biological Chemistry, 293 (23) 9041-9052. doi:10.1074/jbc.RA118.002553
Wang, Conan K. and Craik, David J. (2018) Designing macrocyclic disulfide-rich peptides for biotechnological applications. Nature Chemical Biology, 14 5: 417-427. doi:10.1038/s41589-018-0039-y
Durek, Thomas, Cromm, Philipp M., White, Andrew M., Schroeder, Christina I., Kaas, Quentin, Weidmann, Joachim, Ahmad Fuaad, Abdullah, Cheneval, Olivier, Harvey, Peta J., Daly, Norelle L., Zhou, Yang, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Kessler, Horst, Cai, Minying, Hruby, Victor J., Plowright, Alleyn T. and Craik, David J. (2018) Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. Journal of Medicinal Chemistry, 61 8: 3674-3684. doi:10.1021/acs.jmedchem.8b00170
Turner, Ashlin H., Craik, David J., Kaas, Quentin and Schroeder, Christina I. (2018) Bioactive compounds isolated from neglected predatory marine gastropods. Marine Drugs, 16 4: 118. doi:10.3390/md16040118
Castro, Joel, Grundy, Luke, Deiteren, Annemie, Harrington, Andrea M., O'Donnell, Tracey, Maddern, Jessica, Moore, Jessi, Garcia-Caraballo, Sonia, Rychkov, Grigori Y., Yu, Rilei, Kaas, Quentin, Craik, David J., Adams, David J. and Brierley, Stuart M. (2018) Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology, 175 12: 2384-2398. doi:10.1111/bph.14115
Wang, Conan K., Swedberg, Joakim E., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2018) Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The Journal of Physical Chemistry. B, 122 8: 2261-2276. doi:10.1021/acs.jpcb.7b12419
Israel, Mathilde R., Thongyoo, Panumart, Deuis, Jennifer R., Craik, David J., Vetter, Irina and Durek, Thomas (2018). The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6. Journal of Medicinal Chemistry, 61 (4) 1730-1736. doi:10.1021/acs.jmedchem.7b01609
Poon, Simon, Harris, Karen S, Jackson, Mark A, McCorkelle, Owen C, Gilding, Edward K, Durek, Thomas, van der Weerden, Nicole L, Craik, David J and Anderson, Marilyn A (2017) Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta. Journal of experimental botany, 69 3: 633-641. doi:10.1093/jxb/erx422
Pérez-Peinado, Clara, Almeida Dias, Susana, Domingues, Marco M., Benfield, Aurélie H., Freire, João Miguel, Radis-Baptista, Gandhi, Gaspar, Diana, Castanho, Miguel A. R. B., Craik, David J., Henriques, Sonia Troeira, Veiga, Ana S. and Andreu, David (2017). Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], antimicrobial peptides from rattlesnake venom. The Journal of Biological Chemistry, 293 (5) 1536-1549. doi:10.1074/jbc.RA117.000125
Durek, Thomas, Shelukhina, Irina V., Tae, Han-Shen, Thongyoo, Panumart, Spirova, Ekaterina N., Kudryavtsev, Denis S., Kasheverov, Igor E., Faure, Grazyna, Corringer, Pierre-Jean, Craik, David J., Adams, David J. and Tsetlin, Victor I. (2017) Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors. Scientific Reports, 7 1: 16606. doi:10.1038/s41598-017-16809-0
Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I. and Henriques, Sonia T. (2017). Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa(V)1.7 (vol 1859, pg 835, 2017). Biochimica Et Biophysica Acta-Biomembranes, 1859 (11) 2277-2277. doi:10.1016/j.bbamem.2017.08.008
Ojeda, Paola G. , Henriques, Sonia Troeira, Pan, Yijun, Nicolazzo, Joseph A., Craik, David J. and Wang, Conan K. (2017). Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake. Biopolymers, 108 (5) e23025, doi:10.1002/bip.23025
Wu, Xiaosa, Yen-Hua Huang, Kaas, Quentin, Peta Harvey, Wang, Conan, Tae, Han-Shen, Adams, David J. and Craik, David J. (2017) Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 41: 17101-17112.doi:10.1074/jbc.M117.808386
Agwa, Akello J., Huang, Yen-Hua, Craik, David J., Henriques, Sonia T. and Schroeder, Christina I. (2017) Lengths of the C-terminus and interconnecting loops impact stability of spider-derived gating modifier toxins. Toxins, 9 8: 248. doi:10.3390/toxins9080248
Craik, David J., Lee, Meng-Han, Rehm, Fabian B.H., Tombling, Benjamin, Doffek, Benjamin and Peacock, Hayden (2017). Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds. Bioorganic and Medicinal Chemistry, 26 (10) 2727-2737. doi:10.1016/j.bmc.2017.08.005
Henriques, Sónia Troeira, Lawrence, Nicole, Chaousis, Stephanie, Ravipati, Anjaneya S., Cheneval, Olivier, Benfield, Aurélie H., Elliott, Alysha G., Kavanagh, Angela Maria, Cooper, Matthew A., Chan, Lai Yue, Huang, Yen-Hua and Craik, David J. (2017) Redesigned spider peptide with improved antimicrobial and anticancer properties. ACS Chemical Biology, 12 9: 2324-2334. doi:10.1021/acschembio.7b00459
Wu, Yong, Zhangsun, Dongting, Zhu, Xiaopeng, Kaas, Quentin, Zhangsun, Manqi, Harvey, Peta J., Craik, David J., McIntosh, J. Michael and Luo, Sulan (2017) α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry, 60 13: 5826-5833. doi:10.1021/acs.jmedchem.7b00546
Cranfield, Charles G., Henriques, Sonia Troeira, Martinac, Boris, Duckworth, Paul, Craik, David J. and Cornell, Bruce (2017) Kalata B1 and Kalata B2 have a surfactant-like activity in phosphatidylethanolomine-containing lipid membranes. Langmuir, 33 26: 6630-6637. doi:10.1021/acs.langmuir.7b01642
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Craik, David J. and Du, Junqiao (2017). Cyclotides as drug design scaffolds. Current Opinion in Chemical Biology, 388-16. doi:10.1016/j.cbpa.2017.01.018
Ravipati, Anjaneya S., Poth, Aaron G., Henriques, Sonia Troeira, Bhandari, Murari, Huang, Yen-Hua, Nino, Jaime, Colgrave, Michelle L. and Craik, David J. (2017) Understanding the diversity and distribution of cyclotides from plants of varied genetic origin. Journal of Natural Products, 80 5: 1522-1530. doi:10.1021/acs.jnatprod.7b00061
Joanna Agwa, Lawrence, Nicole, Deplazes, Evelyne, Olivier Cheneval, Rachel Chen, Craik, David J., Schroeder, Christina Ingrid and Sonia Troeira Henriques (2017) Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7. Biochimica et Biophysica Acta. Biomembranes, 1859 5: 835-844.doi:10.1016/j.bbamem.2017.01.020
Zhangsun, Dongting, Zhu, Xiaopeng, Kaas, Quentin, Wu, Yong, Craik, David J. , McIntosh, J. Michael and Luo, Sulan (2017) αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype. Neuropharmacology, 127 243-252. doi:10.1016/j.neuropharm.2017.04.015
Kubota, Tomoya, Durek, Thomas, Dang, Bobo, Finol-Urdaneta, Rocio K., Craik, David J., Kent, Stephen B. H., French, Robert J., Bezanilla, Francisco and Correa, Ana M. (2017) Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET. Proceedings of the National Academy of Sciences, 114 10: E1857-E1865.doi:10.1073/pnas.1700453114
Grage, Stephan L., Sani, Marc-Antoine, Cheneval, Olivier, Henriques, Sonia Troeira, Schalck, Constantin, Heinzmann, Ralf, Mylne, Joshua S., Mykhailiuk, Pavel K., Afonin, Sergii, Komarov, Igor V., Separovic, Frances, Craik, David J. and Ulrich, Anne S. (2017) Orientation and location of the cyclotide kalata B1 in lipid bilayers revealed by solid-state NMR. Biophysical Journal, 112 4: 630-642. doi:10.1016/j.bpj.2016.12.040
Troeira Henriques, Sonia and Craik, David J. (2017) Cyclotide structure and function: the role of membrane binding and permeation. Biochemistry, 56 5: 669-682. doi:10.1021/acs.biochem.6b01212
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Swedberg, Joakim E., Li, Choi Yi, De Veer, Simon J., Wang, Conan K. and Craik, David J. (2017) Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold. Journal of Medicinal Chemistry, 60 2: 658-667. doi:10.1021/acs.jmedchem.6b01509
Abdul Ghani, Hafiza, Henriques, Sonia Troeira, Huang, Yen-Hua, Swedberg, Joakim E. , Schroeder, Christina I. and Craik, David J. (2017) Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies. Biopolymers, 108 1: . doi:10.1002/bip.22927
Verbandt, Sara, Sonia Troeira Henriques, Spincemaille, Pieter, Peta Harvey, Chandhok, Gursimran, Sauer, Vanessa, De Coninck, Barbara, Cassiman, David, Craik, David J., Cammue, Bruno P. A., De Cremer, Kaat and Thevissen, Karin (2017) Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells. Mechanisms of Ageing and Development, 161 B: 247-254.doi:10.1016/j.mad.2016.07.013
Matsuura, Helio N., Poth, Aaron G., Yendo, Anna C. A., Fett-Neto, Arthur G. and Craik, David J. (2016) Isolation and characterization of cyclotides from Brazilian Psychotria: significance in plant defense and co-occurrence with antioxidant alkaloids. Journal of Natural Products, 79 12: 3006-3013. doi:10.1021/acs.jnatprod.6b00492
White, Andrew M. and Craik, David J. (2016) Discovery and optimization of peptide macrocycles. Expert Opinion on Drug Discovery, 11 12: 1151-1163. doi:10.1080/17460441.2016.1245720
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Carstens, Bodil B., Swedberg, Joakim, Berecki, Geza, Adams, David J., Craik, David J. and Clark, Richard J. (2016). Effects of linker sequence modifications on the structure, stability and biological activity of a cyclic α-conotoxin. Biopolymers, 106 (6) 864-875. doi:10.1002/bip.22848
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Angeline (Lai Yue) Chan, Craik, David J. and Daly, Norelle L. (2016) Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Scientific Reports, 6 1: 35347.doi:10.1038/srep35347
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Bleackley, Mark R., Payne, Jennifer A. E., Hayes, Brigitte M. E, Durek, Thomas, Craik, David J., Shafee, Thomas M. A., Poon, Ivan K. H., Hulett, Mark D., Van Der Weerden, Nicole L. and Anderson, Marilyn A. (2016). Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumor cell killing and an enhanced antifungal variant. Antimicrobial Agents and Chemotherapy, 60 (10) 6302-6312. doi:10.1128/AAC.01479-16
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Daly, Norelle L., Gunasekera, Sunithi, Clark, Richard J., Lin, Feng, Wade, John D., Anderson, Marilyn and Craik, David J. (2016). The N-terminal pro-domain of the kalata B1 cyclotide precursor is intrinsically unstructured. Biopolymers, 106 (6) 825-833. doi:10.1002/bip.22977
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Sonia Troeira Henriques, Deplazes, Evelyne, Lawrence, Nicole, Olivier Cheneval, Steph Chaousis, Marco Inserra, Panumart Thongyoo, King, Glenn F, Mark, Alan, Vetter, Irina, Craik, David J. and Schroeder, Christina Ingrid (2016) Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7. The Journal of Biological Chemistry, 291 33: 17049-17065.doi:10.1074/jbc.M116.729095
Swedberg, Joakim E., Mahatmanto, Tunjung, Ghani, Hafiza Abdul, de Veer, Simon J., Schroeder, Christina I., Harris, Jonathan M. and Craik, David J. (2016). Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. Journal of Medicinal Chemistry, 59 (15) 7287-7292. doi:10.1021/acs.jmedchem.6b00557
Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Price, David A., Liras, Spiros and Craik, David J. (2016). Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency and α-helicity and reveal interactions vital for cAMP signaling in vitro. Journal of Biological Chemistry, 291 (30) 15778-15787. doi:10.1074/jbc.M116.724542
Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016) Cyclisation of disulfide-rich conotoxins in drug design applications. European Journal of Organic Chemistry, 2016 21: 3462-3472. doi:10.1002/ejoc.201600402
Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016). Front Cover: Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications (Eur. J. Org. Chem. 21/2016). European Journal of Organic Chemistry, 2016 (21) 3457-3457. doi:10.1002/ejoc.201670211
Sable, Rushikesh, Durek, Thomas, Taneja, Veena, Craik, David J., Pallerla, Sandeep, Gauthier, Ted and Jois, Seetharama (2016) Constrained cyclic peptides as immunomodulatory inhibitors of the CD2:CD58 protein-protein interaction. ACS Chemical Biology, 11 8: 2366-2374. doi:10.1021/acschembio.6b00486
Jennifer Deuis, Zoltan Dekan, Marco Inserra, Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mehdi Mobli, Schroeder, Christina Ingrid, Sonia Troeira Henriques and Vetter, Irina (2016) Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 22: 11829-11842.doi:10.1074/jbc.M116.721662
Weidmann, Joachim and Craik, David J. (2016) Discovery, structure, function, and applications of cyclotides: circular proteins from plants. Journal of Experimental Botany, 67 16: 4801-4812. doi:10.1093/jxb/erw210
Wang, Conan K., Stalmans, Sofie, De Spiegeleer, Bart and Craik, David J. (2016). Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold. Journal of Peptide Science, 22 (5) 305-310. doi:10.1002/psc.2862
Wang, Conan, King, Gordon, Anne Conibear, Maria Ramos, Steph Chaousis, Sonia Troeira Henriques and Craik, David J. (2016) Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. Journal of American Chemical Society, 138 17: 5706-5713.doi:10.1021/jacs.6b02575
Carstens, Bodil B., Berecki, Géza, Daniel, James T., Lee, Han Siean, Jackson, Kathryn A. V., Tae, Han-Shen, Sadeghi, Mahsa, Castro, Joel, O'Donnell, Tracy, Deiteren, Annemie, Brierley, Stuart M., Craik, David J., Adams, David J. and Clark, Richard J. (2016). Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie, 128 (15) 4770-4774. doi:10.1002/ange.201600297
Castro, Joel, Harrington, Andrea M., Garcia-Caraballo, Sonia, Maddern, Jessica, Grundy, Luke, Zhang, Jingming, Page, Guy, Miller, Paul E., Craik, David J., Adams, David J. and Brierley, Stuart M. (2016). α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut, 66 (6) 1083-1094. doi:10.1136/gutjnl-2015-310971
Wang, Conan K., Northfield, Susan E., Huang, Yen-Hua, Ramos, Mariana C. and Craik, David J. (2016). Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry, 109342-349. doi:10.1016/j.ejmech.2016.01.006
Deplazes, Evelyne, Troeira Henriques, Sonia, Smith, Jennifer J., King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016). Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. Biochimica et Biophysica Acta - Biomembranes, 1858 (4) 872-882. doi:10.1016/j.bbamem.2016.02.002
Conibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1) 89-100. doi:10.1002/bip.22767
Ojeda, Paola G., Wang, Conan K. and Craik, David J. (2016). Chlorotoxin: structure, activity, and potential uses in cancer therapy. Biopolymers - Peptide Science, 106 (1) 25-36. doi:10.1002/bip.22748
D'Souza, Charlotte, Henriques, Sonia Troeira, Wang, Conana K., Cheneval, Olivier, Chan, Lai Yue, Bokil, Nilesh J., Sweet, Matthew J. and Craik, David J. (2016). Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer. Biochemistry, 55 (2) 396-405. doi:10.1021/acs.biochem.5b00529
Elliott, Alysha G., Franke, Bastian, Armstrong, David A., Craik, David J., Mylne, Joshua S. and Rosengren, K. Johan (2016) Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49 1: 1-14.doi:10.1007/s00726-016-2333-x
Philippe, Gregoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P., Craik, David J., Dantas De Araujo, Aline and Troeira Henriques, Sonia (2016) Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers - Peptide Science, 106 6: 853-863. doi:10.1002/bip.22893
Vriens, Kim, Cools, Tanne L., Harvey, Peta J., Craik, David J., Braem, Annabel, Vleugels, Jozef, Coninck, Barbara De, Cammue, Bruno P. A. and Thevissen, Karin (2016). The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms. Peptides, 7571-79. doi:10.1016/j.peptides.2015.11.001
Carstens, Bodil B., Berecki, Geza, Daniel, James T., Lee, Han Siean, Jackson, Kathryn A. V., Tae, Han-Shen, Sadeghi, Mahsa, Castro, Joel, O'Donnell, Tracy, Deiteren, Annemie, Brierley, Stuart M., Craik, David J., Adams, David J. and Clark, Richard J. (2016). Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie - International Edition, 55 (15) 4692-4696. doi:10.1002/anie.201600297
Wang, Conan K., Swedberg, Joakim E., Northfield, Susan E. and Craik, David J. (2015). Effects of Cyclization on Peptide Backbone Dynamics. Journal of Physical Chemistry B, 119 (52) 15821-15830. doi:10.1021/acs.jpcb.5b11085
Harris, Karen S., Durek, Thomas, Kaas, Quentin, Poth, Aaron G., Gilding, Edward K., Conlan, Brendon F., Saska, Ivana, Daly, Norelle L., Van Der Weerden, Nicole L., Craik, David J. and Anderson, Marilyn A. (2015). Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase. Nature Communications, 6 (10199) 10199, doi:10.1038/ncomms10199
Gilding, Edward K., Jackson, Mark A., Poth, Aaron G., Henriques, Sonia Troeira, Prentis, Peter J., Mahatmanto, Tunjung and Craik, David J. (2015). Gene coevolution and regulation lock cyclic plant defence peptides to their targets. New Phytologist, 210 (2) 717-730. doi:10.1111/nph.13789
Akcan, Muharrem, Clark, Richard J., Daly, Norelle L., Conibear, Anne C., de Faoite, Andrew, Heghinian, Mari D., Sahil, Talwar, Adams, David J., Mari, Frank and Craik, David J. (2015). Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins. Peptide Science, 104 (6) 682-692. doi:10.1002/bip.22699
Chan, Lai Yue, Craik, David J. and Daly, Norelle L. (2015). Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration. Bioscience Reports, 35 (6) e00270, e00270-e00270. doi:10.1042/BSR20150210
Craik, David J. (2015). Preface. Plant Cyclotides, 76XI-XIII. doi:10.1016/S0065-2296(15)00118-4
Ravipati, Anjaneya S., Henriques, Sónia Troeira, Poth, Aaron G., Kaas, Quentin, Wang, Conan K., Colgrave, Michelle L. and Craik, David J. (2015). Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae. ACS Chemical Biology, 10 (11) 2491-2500. doi:10.1021/acschembio.5b00454
Craik, David J. (2015). Overview on the discovery and applications of cyclotides. Advances in Botanical Research, 76 (7) 1-13. doi:10.1016/bs.abr.2015.09.008
Burman, Robert, Yeshak, Mariamawit Y., Larsson, Sonny, Craik, David J., Rosengren, K. Johan and Goeransson, Ulf (2015). Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae. Frontiers in Plant Science, 6 (855) 855, 1-13. doi:10.3389/fpls.2015.00855
Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A. and Craik, David J. (2015). Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry, 103175-184. doi:10.1016/j.ejmech.2015.08.046
de Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015). Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 (20) 8257-8268. doi:10.1021/acs.jmedchem.5b01148
Henriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Stephanie, Sani, Marc-Antoine, Poth, Aaron G., Separovic, Frances and Craik, David J. (2015). The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells. Chemistry and Biology, 22 (8) 3107, 1087-1097. doi:10.1016/j.chembiol.2015.07.012
Yu, Rilei, Seymour, Victoria A. L., Berecki, Geza, Jia, Xinying, Akcan, Muharrem, Adams, David J., Kaas, Quentin and Craik, David J. (2015). Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports, 5 (Art No.: 13264) 13264, doi:10.1038/srep13264
Huang, Yen-Hua, Henriques, Sonia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin and Craik, David J. (2015). Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports, 5 (1) 12974, 1-15. doi:10.1038/srep12974
Himeno, Kohei, Rosengren, K. Johan, Inoue, Tomoko, Perez, Rodney H., Colgrave, Michelle L., Lee, Han Siean, Chan, Lai Y., Henriques, Sonia Troeira, Fujita, Koji, Ishibashi, Naoki, Zendo, Takeshi, Wilaipun, Pongtep, Nakayama, Jiro, Leelawatcharamas, Vichien, Jikuya, Hiroyuki, Craik, David J. and Sonomoto, Kenji (2015). Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium. Biochemistry, 54 (31) 4863-4876. doi:10.1021/acs.biochem.5b00196
Vriens, Kim, Cools, Tanne L., Harvey, Peta J., Craik, David J., Spincemaille, Pieter, Cassiman, David, Braem, Annabel, Vleugels, Jozef, Nibbering, Peter H., Drijfhout, Jan Wouter, De Coninck, Barbara, Cammue, Bruno P. A. and Thevissen, Karin (2015). Synergistic activity of the plant defensin HsAFP1 and caspofungin against Candida albicans biofilms and planktonic cultures. PLoS ONE, 10 (8) e0132701, 1-22. doi:10.1371/journal.pone.0132701
Luo, Sulan, Zhangsun, Dongting, Harvey, Peta J., Kaas, Quentin, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Li, Xiaodan, Tsetlin, Victor. I., Christensen, Sean, Romero, Haylie K., McIntrye, Melissa, Dowell, Cheryl, Baxter, James, C., Elmslie, Keith S., Craik, David J. and McIntosh, Michael (2015). Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 112 (30) e4026-e4035. doi:10.1073/pnas.1503617112
de Veer, Simon J., Swedberg, Joakim E., Akcan, Muharrem, Rosengren, K. Johan, Brattsand, Maria, Craik, David J. and Harris, Jonathan M. (2015). Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. Biochemical Journal, 469 (2) 243-253. doi:10.1042/BJ20150412
Holliday, Gemma L., Bairoch, Amos, Bagos, Pantelis G., Chatonnet, Arnaud, Craik, David J., Flinn, Robert D., Henrissat, Bernard, Landsman, David, Manning, Gerard, Nagano, Nozomi, O'Donovan, Claire, Pruitt, Kim D., Rawlings, Neil D., Saier, Milton, Sowdhamini, Ramanathan, Spedding, Michael, Srinivasan, Narayanaswamy, Vriend, Gert, Babbitt, Patricia C. and Bateman, Alex (2015). Key challenges for the creation and maintenance of specialist protein resources. Proteins: Structure, Function and Bioinformatics, 83 (6) 1005-1013. doi:10.1002/prot.24803
Kaas, Quentin and Craik, David J. (2015). Bioinformatics-aided venomics. Toxins, 7 (6) 2159-2187. doi:10.3390/toxins7062159
Bernath-Levin, Kalia, Nelson, Clark, Elliott, Alysha G., Jayasena, Achala S., Millar, A. Harvey, Craik, David J. and Mylne, Joshua S. (2015). Peptide macrocyclization by a bifunctional endoprotease. Chemistry and Biology, 22 (5) 571-582. doi:10.1016/j.chembiol.2015.04.010
Wang, Conan K., Northfield, Susan Ellen, Swedberg, Joakim E., Colless, Barbara, Chaousis, Stephanie, Price, David A., Liras, Spiros and Craik, David J. (2015). Exploring experimental and computational markers of cyclic peptides: charting islands of permeability. European Journal of Medicinal Chemistry, 97202-213. doi:10.1016/j.ejmech.2015.04.049
Malik, U., Silva, O. N., Fensterseifer, I. C. M., Chan, A., Clark, R. J., Franco, O. L., Daly, N. L. and Craik, D. J. (2015). In vivo efficacy of anuran rypsin inhibitory peptides against Staphylococcal Skin infection and the impact of peptide cyclization. Antimicrobial Agents and Chemotherapy, 59 (4) 2113-2121. doi:10.1128/AAC.04324-14
Zhang, Jun, Li, Jintian, Huang, Zebo, Yang, Bing, Zhang, Xiaojie, Li, Dehua, Craik, David J., Baker, Alan J. M., Shu, Wensheng and Liao, Bin (2015). Transcriptomic screening for cyclotides and other cysteine-rich proteins in the metallophyte Viola baoshanensis. Journal of Plant Physiology, 17817-26. doi:10.1016/j.jplph.2015.01.017
Zhangsun, Dongting, Zhu, Xiaopeng, Wu, Yong, Hu, Yuanyan, Kaas, Quentin, Craik, David J., McIntosh, J. Michael and Luo, Sulan (2015). Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding. The Journal of Biological Chemistry, 290 (15) 9855-9862. doi:10.1074/jbc.M114.632646
Haugaard-Kedstrom, Linda, Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A. D., Rinderknecht, Ernst, Wade, John D., Craik, David J. and Rosengren, Karl Johan (2015). Solution structure, aggregation behavior, and flexibility of human relaxin-2. ACS Chemical Biology, 10 (3) 891-900. doi:10.1021/cb500918v
Huang, Yen-Hua, Chaousis, Steph, Cheneval, Olivier, Craik, David J. and Henriques, Sonia Troeira (2015). Optimization of the cyclotide framework to improve cell penetration properties. Frontiers in Pharmacology, 6 (17) 17, 1-7. doi:10.3389/fphar.2015.00017
Fensterseifer, Isabel C. M., Silva, Osmar N., Malik, Uru, Ravipati, Anjaneya S., Novaes, Natasha R. F., Miranda, Paolo R. R., Rodrigues, Elaine A., Moreno, Susana E., Craik, David J. and Franco, Octavio L. (2015). Effects of cyclotides against cutaneous infections caused by Staphylococcus aureus. Peptides, 63 (3) 38-42. doi:10.1016/j.peptides.2014.10.019
Durek, Thomas and Craik, David J. (2015). Therapeutic conotoxins: a US patent literature survey. Expert Opinion in Therapeutic Patents, 25 (10) 1159-1173. doi:10.1517/13543776.2015.1054095
Babbitt, Patricia C, Bagos, Pantelis G, Bairoch, Amos, Bateman, Alex, Chatonnet, Arnaud, Chen, Mark Jinan, Craik, David J, Finn, Robert D, Gloriam, David, Haft, Daniel H, Henrissat, Bernard, Holliday, Gemma L, Isberg, Vignir, Kaas, Quentin, Landsman, David, Lenfant, Nicolas, Manning, Gerard, Nagano, Nozomi, Srinivasan, Narayanaswamy, O'Donovan, Claire, Pruitt, Kim D, Sowdhamini, Ramanathan, Rawlings, Neil D, Saier Jr., Milton H, Sharman, Joanna L, Spedding, Michael, Tsirigos, Konstantinos D, Vastermark, Ake and Vriend, Gerrit (2015). Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. Database The Journal of Biological Databases and Curation, 2015 (bav063) doi:10.1093/database/bav063
Oguis, Georgianna Kae, Kan, Meng-Wei and Craik, David J. (2015). Natural functions and structure-activity relationships of cyclotides. Advances in Botanical Research, 76187-226. doi:10.1016/bs.abr.2015.10.001
Zhang, Jun, Hua, Zhengshuang, Huang, Zebo, Chen, QiZhu, Long, Qingyun, Craik, David J., Baker, Alan J. M., Shu, Wensheng and Liao, Bin (2014). Two Blast-independent tools, CyPerl and CyExcel, for harvesting hundreds of novel cyclotides and analogues from plant genomes and protein databases. Planta, 241 (4) 929-940. doi:10.1007/s00425-014-2229-5
Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014). Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 (49) 17504-17509. doi:10.1073/pnas.1417611111
Conibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014). Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 (49) 14257-14266. doi:10.1021/jp507754c
Mahatmanto, Tunjung, Mylne, Joshua S., Poth, Aaron G., Swedberg, Joakim E., Kaas, Quentin, Schaefer, Hanno and Craik, David J. (2014). The evolution of Momordica cyclic peptides. Molecular Biology and Evolution, 32 (2) 392-405. doi:10.1093/molbev/msu307
Nielsen, Daniel S., Hoang, Huy N., Lohman, Rink-Jan, Hill, Timothy A., Lucke, Andrew J., Craik, David J., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros and Fairlie, David P. (2014). Improving on nature: making a cyclic heptapeptide orally bioavailable. Angewandte Chemie - International Edition, 53 (45) 12059-12063. doi:10.1002/anie.201405364
Vink, Simone, Daly, Norelle L., Steen, Natalie, Craik, David J. and Alewood, Paul F. (2014). Holocyclotoxin-1, a cystine knot toxin from Ixodes holocyclus. Toxicon, 90 (1) 308-317. doi:10.1016/j.toxicon.2014.08.068
Taylor, Carol M., Northfield, Susan E., Wang, Conan K. and Craik, David J. (2014). Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1. Tetrahedron, 70 (42) 7669-7674. doi:10.1016/j.tet.2014.06.058
Wang, Conan K., King, Gordon J., Northfield, Susan E., Ojeda, Paola G. and Craik, David J. (2014). Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angewandte Chemie - International Edition, 53 (42) 11236-11241. doi:10.1002/anie.201406563
Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor C. G., Kok, W. Mei, Liu, Ligong, Lucke, Andrew J., Stoermer, Martin J., Schroeder, Christina I., Chaousis, Stephanie, Colless, Barbara, Bernhardt, Paul V., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Craik, David J. and Fairlie, David P. (2014). Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed. ACS Medicinal Chemistry Letters, 5 (10) 1148-1151. doi:10.1021/ml5002823
Ojeda, Paola G., Chan, Lai Y., Poth, Aaron G., Wang, Conan K. and Craik, David J. (2014). The role of disulfide bonds in structure and activity of chlorotoxin. Future Medicinal Chemistry, 6 (15) 1617-1628. doi:10.4155/FMC.14.93
Conibear, Anne C. and Craik, David J. (2014). The chemistry and biology of theta defensins. Angewandte Chemie International Edition, 53 (40) 10612-10623. doi:10.1002/anie.201402167
Spincemaille, Pieter, Alborzinia, Hamed, Dekervel, Jeroen, Windmolders, Petra, van Pelt, Jos, Cassiman, David, Cheneval, Olivier, Craik, David J., Schur, Julia, Ott, Ingo, Wolfl, Stefan, Cammue, Bruno P. A and Thevissen, Karin (2014). The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells. Molecules, 19 (9) 15088-15102. doi:10.3390/molecules190915088
Wang, Conan K., Northfield, Susan E., Swedberg, Joakim E., Harvey, Peta J., Mathiowetz, Alan M., Price, David A, Liras, Spiros and Craik, David J. (2014). Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. Journal of Physical Chemistry B, 118 (38) 11129-11136. doi:10.1021/jp506678f
Henriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Steph, Wang, Conan and Craik, David J. (2014). Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem, 15 (13) 1956-1965. doi:10.1002/cbic.201402144
Delattin, Nicolas, De Brucker, Katrijn, Craik, David J., Cheneval, Olivier, De Coninck, Barbara, Cammue, Bruno P. A. and Thevissen, Karin (2014). Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation. Antimicrobial Agents and Chemotherapy, 58 (8) 4974-4977. doi:10.1128/AAC.03336-14
Anne Conibear and Craik, David J. (2014) Chemie und Biologie von Theta-Defensinen. Angewandte Chemie, 126 40: 10786-10798.doi:10.1002/ange.201402167
Berecki, G., Daly, N. L., Huang, Y. H., Vink, S., Craik, D. J., Alewood, P. F. and Adams, D. J. (2014). Effects of arginine 10 to lysine substitution on omega-conotoxin CVIE and CVIF block of Ca(v)2.2 channels. British Journal of Pharmacology, 171 (13) 3313-3327. doi:10.1111/bph.12686
D'Souza, Charlotte, Troeira Henriques, Sonia, Wang, Conan K. and Craik, David J. (2014). Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1. European Journal of Medicinal Chemistry, 8810-18. doi:10.1016/j.ejmech.2014.06.047
Cheneval, Olivier, Schroeder, Christina I., Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A. and Craik, David J. (2014). Fmoc-based synthesis of disulfide-rich cyclic peptides. Journal of Organic Chemistry, 79 (12) 5538-5544. doi:10.1021/jo500699m
Paulsen, B. S., Craik, D. J., Dunstan, D. E., Stone, B. A. and Bacic, A. (2014). The Yariv reagent: behaviour in different solvents and interaction with a gum arabic arabinogalactanprotein. Carbohydrate Polymers, 106 (1) 460-468. doi:10.1016/j.carbpol.2014.01.009
Mahatmanto, Tunjung, Poth, Aaron, Mylne, Joshua S. and Craik, David J. (2014). A comparative study of extraction methods reveals preferred solvents for cystine knot peptide isolation from Momordica cochinchinensis seeds. Fitoterapia, 9522-33. doi:10.1016/j.fitote.2014.02.016
Akondi, Kalyana, Muttenthaler, Markus, Dutertre, Sébastien, Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2014). Discovery, synthesis, and structure: activity relationships of conotoxins. Chemical Reviews, Articles ASAP (11) 1-33. doi:10.1021/cr400401e
Northfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014). Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 (2) 248-257. doi:10.1016/j.ejmech.2014.03.011
Elliott, Alysha G., Delay, Christina, Liu, Huanle, Phua, Zaiyang, Rosengren, K. Johan, Benfield, Aurelie H., Panero, Jose L., Colgrave, Michelle L., Jayasena, Achala S., Dunse, Kerry M., Anderson, Marilyn A., Schilling, Edward E., Ortiz-Barrientos, Daniel, Craik, David J. and Mylne, Joshua S. (2014). Evolutionary origins of a bioactive peptide buried within preproalbumin. The Plant Cell, 26 (3) 981-995. doi:10.1105/tpc.114.123620
Delattin, Nicolas, De Brucker, Katrijn, Craik, David J., Cheneval, Olivier, Frohlich, Mirjam, Veber, Matija, Girandon, Lenart, Davis, Tayla, R., Weeks, Anne E., Kumamoto, Carol A., Cos, Paul, Coenye, Tom, De Coninck, Barbara, Cammue, Bruno P. A. and Thevissen, Karin (2014). The plant-derived decapeptide OSIP108 interferes with Candida albicans biofilm formation without affecting cell viability. Antimicrobial Agents and Chemotherapy, 58 (5) 2647-2656. doi:10.1128/AAC.01274-13
Schroeder, Christina I., Swedberg, Joakim E., Withka, Jane M., Rosengren, K. Johan, Akcan, Muharrem, Clayton, Daniel J., Daly, Norelle L., Cheneval, Olivier, Borzilleri, Kris A., Griffor, Matt, Stock, Ingrid, Colless, Barbara, Walsh, Phillip, Sunderland, Phillip, Reyes, Allan, Dullea, Robert, Ammirati, Mark, Liu, Shenping, McClure, Kim F., Tu, Meihua, Bhattacharya, Samit K., Liras, Spiros, Price, David A. and Craik, David J. (2014). Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chemistry and Biology, 21 (2) 284-294. doi:10.1016/j.chembiol.2013.11.014
Lay, Fung T., Poon, Simon, McKenna, James A., Connelly, Angela A., Barbeta, Barbara L., McGinness, Bruce S., Fox, Jennifer L., Daly, Norelle L., Craik, David J., Heath, Robyn L. and Anderson, Marilyn A. (2014). The C-terminal propeptide of a plant defensin confers cytoprotective and subcellular targeting functions. BMC Plant Biology, 14 (1) 41, 41.1-41.13. doi:10.1186/1471-2229-14-41
Conibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014). The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 (3) 451-459. doi:10.1002/cbic.201300568
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4) 1035-1038. doi:10.1002/ange.201308898
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4) 1017-1020. doi:10.1002/anie.201308898
Jia, Xinying, Schulte, Leigh, Loukas, Alex, Pickering, Darren, Pearson, Mark, Mobli, Mehdi, Jones, Alun, Rosengren, Karl J., Daly, Norelle L., Gobert, Geoffrey N., Jones, Malcolm K., Craik, David J. and Mulvenna, Jason (2014). Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 (10) 1-26. doi:10.1074/jbc.M113.531558
Jia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014). Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press (10) 1-25. doi:10.1074/jbc.M113.539262
Luo, Sulan, Zhangsun, Dongting, Schroeder, Christina I., Zhu, Xiaopeng, Hu, Yuanyan, Wu, Yong, Weltzin, Maegan M., Eberhard, Spencer, Kaas, Quentin, Craik, David J., McIntosh, J. Michael and Whiteaker, Paul (2014). A novel alpha4/7-conotoxin LvIA from Conus lividus that selectively blocks alpha3 beta2 vs. alpha6/alpha3 beta2 beta3 nicotinic acetylcholine receptors. FASEB Journal, Early Edition (4) 1-12. doi:10.1096/fj.13-244103
Kedarisetti, Pradyumna, Mizianty, Marcin J., Kaas, Quentin, Craik, David J. and Kurgan, Lukasz (2014). Prediction and characterization of cyclic proteins from sequences in three domains of life. Biochimica et Biophysica Acta: Proteins and Proteomics, 1844 (1) 181-190. doi:10.1016/j.bbapap.2013.05.002
Wang, Conan K., Gruber, Christian W., Cemazar, Masa, Siatskas, Christopher, Tagore, Prascilla, Payne, Natalie, Sun, Guizhi, Wang, Shunhe, Bernard, Claude C. and Craik, David J. (2014). Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chemical Biology, 9 (1) 156-163. doi:10.1021/cb400548s
Moon, H., Lee, C. S., Inder, K. L., Sharma, S., Choi, E., Black, D. M., Lê Cao, K.-A., Winterford, C., Coward, J. I., Ling, M. T., Craik, D. J., Parton, R. G., Russell, P.J., Hill, M. M. and The Australian Prostate Cancer BioResource (2014). PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer. Oncogene, 33 (27) 3561-3570. doi:10.1038/onc.2013.315
Craik, D. P. L. Aude, Linke, N. M., Harty, T. P., Ballance, C. J., Lucas, D. M., Steane, A. M. and Allcock, D. T. C. (2014). Microwave control electrodes for scalable, parallel, single-qubit operations in a surface-electrode ion trap. Applied Physics B: Lasers and Optics, 114 (1-2) 3-10. doi:10.1007/s00340-013-5716-7
Rosengren, K. Johan, Daly, Norelle L., Harvey, Peta J. and Craik, David J. (2013). The Self-Association of the Cyclotide Kalata B2 in Solution is Guided by Hydrophobic Interactions (vol 100, pg 453, 2013). Biopolymers, 102 (1) 136-136. doi:10.1002/bip.22443
Daly, Norelle L., Thorstholm, Louise, Greenwood, Kathryn P., King, Gordon J., Rosengren, K. Johan, Heras, Begona, Martin, Jennifer L. and Craik, David J. (2013). Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor. Journal of Biological Chemistry, 288 (50) 36141-36148. doi:10.1074/jbc.M113.528240
Akcan, Muharrem, Stroud, Mark R., Hansen, Stacey J., Clark, Richard J., Daly, Norelle L., Craik, David J. and Olson, James M. (2013). Erratum: Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy (Journal of Medicinal Chemistry (2011) 54 (782-787) DOI: 10.1021/jm101018r). Journal of Medicinal Chemistry, 56 (23) 9807-9807. doi:10.1021/jm4016119
Arnison, Paul G., Bibb, Mervyn J., Bierbaum, Gabriele, Bowers, Albert A., Bugni, Tim S., Bulaj, Grzegorz, Camarero, Julio A., Campopiano, Dominic J., Challis, Gregory L., Clardy, Jon, Cotter, Paul D., Craik, David J., Dawson, Michael, Dittmann, Elke, Donadio, Stefano, Dorrestein, Pieter C., Entian, Karl-Dieter, Fischbach, Michael A., Garavelli, John S., Göransson, Ulf, Gruber, Christian W., Ha, Daniel H., Hemscheidt, Thomas K., Hertweck, Christian, Hill, Colin, Horswill, Alexander R., Jaspars, Marcel, Kelly, Wendy L., Klinman, Judith P., Kuipers, Oscar P. and Link, A. James (2013). Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F). Natural Product Reports, 30 (12) 1568-1569. doi:10.1039/c3np90040a
De Coninck, Barbara, Carron, Delphine, Tavormina, Patrizia, Willem, Lander, Craik, David J., Vos, Christine, Thevissen, Karin, Mathys, Janick and Cammue, Bruno P. A. (2013). Mining the genome of Arabidopsis thaliana as a basis for the identification of novel bioactive peptides involved in oxidative stress tolerance. Journal of Experimental Biology, 64 (17) 5297-5307. doi:10.1093/jxb/ert295
Grishin, Anton A., Cuny, Hartmut, Hung, Andrew, Clark, Richard J., Brust, Andreas, Akondi, Kalyana, Alewood, Paul F., Craik, David J. and Adams, David J. (2013). Identifying key amino acid residues that affect alpha-conotoxin AuIB inhibition of alpha3beta4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 288 (48) 34428-34442. doi:10.1074/jbc.M113.512582
Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Craik, David J., Freissmuth, Michael and Gruber, Christian W. (2013). Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America, 110 (52) 21183-21188. doi:10.1073/pnas.1311183110
Henriques, Sónia Troeira, Thorstholm, Louise, Huang, Yen-Hua, Getz, Jennifer A., Daugherty, Patrick S. and Craik, David J. (2013). A novel quantitative kinase assay using bacterial surface display and flow cytometry. PloS One, 8 (11) e80474, e80474.1-e80474.7. doi:10.1371/journal.pone.0080474
Luo, Sulan, Zhangsun, Dongting, Zhu, Xiaopeng, Wu, Yong, Hu, Yuanyan, Christensen, Sean, Harvey, Peta J., Akcan, Muharrem, Craik, David J. and McIntosh, Michael (2013). Characterization of a novel alpha-conotoxin TxID from Conus textile that potently blocks rat alpha3/beta4 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, Article ASAP (13) A-I. doi:10.1021/jm401254c
Craik, David J. and Malik, Uru (2013). Cyclotide biosynthesis (vol 17, pg 546, 2013). Current Opinion in Chemical Biology, 17 (5) 868-868. doi:10.1016/j.cbpa.2013.09.010
Torcato, Ines M., Huang, Yen-Hua, Franquelim, Henri G., Gaspar, Diana D., Craik, David J., Castanho, Miguel A. R. B. and Henriques, Sonia Troeira (2013). The Antimicrobial Activity of Sub3 is Dependent on Membrane Binding and Cell-Penetrating Ability. Chembiochem, 14 (15) 2013-2022. doi:10.1002/cbic.201300274
He, Wen-Jun, Chan, Lai Yue, Clark, Richard J., Tang, Jun, Zeng, Guang-Zhi, Franco, Octavio L., Cantacessi, Cinzia, Craik, David J., Daly, Norelle L. and Tan, Ning-Hua (2013). Novel inhibitor cystine knot peptides from momordica charantia. PLoS ONE, 8 (10) e75334, e75334.1-e75334.10. doi:10.1371/journal.pone.0075334
Inserra, Marco C., Kompella, Shiva N., Vetter, Irina, Brust, Andreas, Daly, Norelle L., Cuny, Hartmut, Craik, David J., Alewood, Paul F., Adams, David J. and Lewis, Richard J. (2013). Isolation and characterization of alpha-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology, 86 (6) 791-799. doi:10.1016/j.bcp.2013.07.016
Clark, Richard J., Preza, Gloria C., Tan, Chia Chia, van Dijk, Johannes W. A., Fung, Eileen, Nemeth, Elizabeta, Ganz, Tomas and Craik, David J. (2013). Design, synthesis and characterisation of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers: Peptide Science, 100 (5) 519-526. doi:10.1002/bip.22350
Gerlach, Samantha L., Göransson, Ulf, Kaas, Quentin, Craik, David J. and Gruber, Christian W. (2013). A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic and peptidomic analysis. Biopolymers: Peptide Science, 100 (5) 433-437. doi:10.1002/bip.22258
Poth, Aaron, Chan, Lai Y. and Craik, David J. (2013). Cyclotides as grafting frameworks for protein engineering and drug design applications. Biopolymers: Peptide Science, 100 (5) 480-491. doi:10.1002/bip.22284
Malagon, David, Botterill, Bonnie, Gray, Darren J., Lovas, Erica, Duke, Mary, Gray, Christian, Kopp, Steven R., Knott, Lyn M., McManus, Donald P., Daly, Norelle L., Mulvenna, Jason, Craik, David J. and Malcolm K Jones (2013). Anthelminthic activity of the cyclotides (kalata B1 and B2) against schistosome parasites. Biopolymers, 100 (5) 461-470. doi:10.1002/bip.22229
Craik, David J. (2013). Foreword for ICCP2012 issue of Biopolymers Peptide Science Circular Proteins: never ending possibilities. Biopolymers: Peptide Science, 100 (5) iii-v. doi:10.1002/bip.22366
Craik, David J. and Malik, Uru (2013). Cyclotide biosynthesis. Current Opinion In Chemical Biology, 17 (4) 546-554. doi:10.1016/j.cbpa.2013.05.033
Garvey, Megan, Meehan, Sarah, Gras, Sally L., Schirra, Horst, Craik, David J., Van der Weerden, Nicole L., Anderson, Marilyn A., Gerrard, Juliet A. and Carver, John A. (2013). A radish seed antifungal peptide with a high amyloid fibril-forming propensity. Biochimica et Biophysica Acta: Proteins and Proteomics, 1834 (8) 1615-1623. doi:10.1016/j.bbapap.2013.04.030
Rosengren, K. Johan, Daly, Norelle L., Harvey, Peta J. and Craik, David J. (2013). The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions. Peptide Science, Accepted Article (5) 1-16. doi:10.1002/bip.22269
Craik, David J. (2013). Joseph Rudinger memorial lecture: discovery and applications of cyclotides. Journal of Peptide Science, 19 (7) 393-407. doi:10.1002/psc.2523
Getz, Jennifer A., Cheneval, Olivier, Craik, David J. and Daugherty, Patrick S. (2013). Design of a cyclotide antagonist of neuropilin-1 and-2 that potently inhibits endothelial cell migration. ACS Chemical Biology, 8 (6) 1147-1154. doi:10.1021/cb4000585
Gruendemann, Carsten, Thell, Kathrin, Lengen, Karin, Garcia-Kaeufer, Manuel, Huang, Yen-Hua, Huber, Roman, Craik, David J., Schabbauer, Gernot and Gruber, Christian W. (2013). Cyclotides suppress human T-Lymphocyte proliferation by an interleukin 2-dependent mechanism. Plos One, 8 (6) e68016, e68016.1-e68016.12. doi:10.1371/journal.pone.0068016
Yu, Rilei, Kompella, Shiva N., Adams, David J., Craik, David J. and Kaas, Quentin (2013). Determination of the alpha-conotoxin Vc1.1 binding site on the alpha 9 alpha 10 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry, 56 (9) 3557-3567. doi:10.1021/jm400041h
Cowper, Ben, Craik, David J. and Macmillan, Derek (2013). Making ends meet: chemically mediated circularization of recombinant proteins. ChemBioChem, 14 (7) 809-812. doi:10.1002/cbic.201300105
Quimbar, Pedro, Malik, Uru, Sommerhoff, Christian P., Kaas, Quentin, Chan, Lai Y., Huang, Yen-Hua, Grundhuber, Maresa, Dunse, Kerry, Craik, David J., Anderson, Marilyn A. and Daly, Norelle L. (2013). High-affinity cyclic peptide matriptase inhibitors. Journal of Biological Chemistry, 288 (19) 13885-13896. doi:10.1074/jbc.M113.460030
Kaas, Quentin and Craik, David J. (2013) NMR of plant proteins. Progress in Nuclear Magnetic Resonance Spectroscopy, 71 1-34.doi:10.1016/j.pnmrs.2013.01.003
Conibear, Anne C., Rosengren, K. Johan, Daly, Norelle L., Henriques, Sonia Troeira and Craik, David J. (2013). The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity. Journal of Biological Chemistry, 288 (15) 10830-10840. doi:10.1074/jbc.M113.451047
Chan, Lai Yue, Zhang, Veronica M., Huang, Yen-hua, Waters, Norman C., Bansal, Paramjit S., Craik, David J. and Daly, Norelle L. (2013). Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity. Chembiochem, 14 (5) 617-624. doi:10.1002/cbic.201300034
Torcato, Inês M., Huang, Yen-Hua, Franquelim, Henri G., Gaspar, Diana, Craik, David J., Castanho, Miguel A. R. B. and Henriques, Sonia Troeira (2013). Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria. Biochimica et Biophysica Acta, 1828 (3) 944-955. doi:10.1016/j.bbamem.2012.12.002
Akcan, Muharrem, Cao, Ying, Chongzu, Fan and Craik, David J. (2013). The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold. Bioorganic and Medicinal Chemistry, 21 (12) 3590-3596. doi:10.1016/j.bmc.2013.02.012
Luo, Sulan, Zhangsun, Dongting, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, McIntyre, Melissa, Christensen, Sean, Akcan, Muharrem, Craik, David J. and McIntosh, J. Michael (2013). Characterization of a novel α-conotoxin from Conus textile that selectively targets alpha 6/alpha 3 beta 2 beta 3 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 288 (2) 894-902. doi:10.1074/jbc.M112.427898
Arnison, Paul G., Bibb, Mervyn J., Bierbaum, Gabriele, Bowers, Albert A., Bugni, Tim S., Bulaj, Grzegorz, Camarero, Julio A., Campopiano, Dominic J., Challis, Gregory L., Clardy, Jon, Cotter, Paul D., Craik, David J., Dawson, Michael, Dittmann, Elke, Donadio, Stefano, Dorrestein, Pieter C., Entian, Karl-Dieter, Fischbach, Michael A., Garavelli, John S., Goeransson, Ulf, Gruber, Christian W., Haft, Daniel H., Hemscheidt, Thomas K., Hertweck, Christian, Hill, Colin, Horswill, Alexander R., Jaspars, Marcel, Kelly, Wendy L., Klinman, Judith P., Kuipers, Oscar P. and Link, A. James (2013). Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports, 30 (1) 108-160. doi:10.1039/c2np20085f
Craik, David J., Fairlie, David P., Liras, Spiros and Price, David (2013). The Future of Peptide-based Drugs. Chemical Biology and Drug Design, 81 (1) 136-147. doi:10.1111/cbdd.12055
Gao, Bin, Harvey, Peta J., Craik, David J., Ronjat, Michel, De Waard, Michel and Zhu, Shunyi (2013). Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold. Bioscience Reports, 33 (3) e00047, e00047.1-e00047.15. doi:10.1042/BSR20130052
Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2013). Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides. Current Protein and Peptide Science, 14 (6) 532-552. doi:10.2174/13892037113149990069
Craik, David J. and Schroeder, Christina I. (2013). Peptides from Mamba venom as pain killers. Angewandte Chemie-International Edition, 52 (11) 3071-3073. doi:10.1002/anie.201209851
Chan, Lai Yue, He, Wenjun, Tan, Ninghua, Zeng, Guangzhi, Craik, David J. and Daly, Norelle L. (2013). A new family of cystine knot peptides from the seeds of Momordica cochinchinensis. Peptides, 39 (1) 29-35. doi:10.1016/j.peptides.2012.09.018
Conibear, Anne C., Rosengren, K. Johan, Harvey, Peta J. and Craik, David J. (2012). Structural characterization of the cyclic cystine ladder motif of θ-defensins. Biochemistry, 51 (48) 9718-9726. doi:10.1021/bi301363a
Wang, Conan K., Wacklin, Hanna P. and Craik, David J. (2012). Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions. Journal of Biological Chemistry, 287 (52) 43884-43898. doi:10.1074/jbc.M112.421198
Eliasen, Rasmus, Daly, Norelle L., Wulff, Birgitte S., Andresen, Thomas L., Conde-Frieboes, Kilian W. and Craik, David J. (2012). Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1. Journal of Biological Chemistry, 287 (48) 40493-40501. doi:10.1074/jbc.M112.395442
Hall, Kristopher, Lee, Tzong-Hsien, Daly, Norelle L., Craik, David J. and Aguilar, Marie-Isabel (2012). Gly6 of kalata B1 is critical for the selective binding to phosphatidylethanolamine membranes. BBA: Biomembranes, 1818 (9) 2354-2361. doi:10.1016/j.bbamem.2012.04.007
Henriques, Sonia Troeira, Huang, Yen-Hua, Castanho, Miguel A. R. B., Bagatolli, Luis A., Sonza, Secondo, Tachedjan, Gilda, Daly, Norelle L. and Craik, David J. (2012). Phosphatidylethanolamine-binding is a conserved feature of cyclotide-membrane interactions. Journal of Biological Chemistry, 287 (40) 33629-33643. doi:10.1074/jbc.M112.372011
Conlan, Brendon F., Colgrave, Michelle L., Gillon, Amanda D., Guarino, Rosemary, Craik, David J. and Anderson, Marilyn A. (2012). Insights into processing and cyclization events associated with biosynthesis of the cyclic peptide kalata B1. Journal of Biological Chemistry, 287 (33) 28037-28046. doi:10.1074/jbc.M112.347823
Daly, Norelle, David Wilson and Craik, David (2012). Cyclic peptides from plants and their promise in drug design. Australian Biochemist, 43 (2) 7-9.
Craik, David J. (2012). Protein folding: Turbo-charged crosslinking. Nature Chemistry, 4 (8) 600-602. doi:10.1038/nchem.1417
Conibear, Anne, Daly, Norelle L. and Craik, David J. (2012). Quantification of small cyclic disulfide-rich peptides. Biopolymers, 98 (6) 518-524. doi:10.1002/bip.22121
Cemazar, M., Kwon, S., Mahatmanto, T., Ravipati, A. S. and Craik, David J. (2012). Discovery and applications of disulfide-rich cyclic peptides. Current Topics in Medicinal Chemistry, 12 (14) 1534-1545. doi:10.2174/156802612802652484
Mylne, Joshua S., Chan, Lai Yue, Chanson, Aurelie H., Daly, Norelle L., Schaefer, Hanno, Bailey, Timothy L., Nguyencong, Philip, Cascales, Laura and Craik, David J. (2012). Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase–mediated biosynthesis. Plant Cell, 24 (7) 2765-2778. doi:10.1105/tpc.112.099085
Craik, David J. and Allewell, Norma M. (2012). Thematic minireview series on circular proteins. Journal of Biological Chemistry, 287 (32) 26999-27000. doi:10.1074/jbc.R112.390344
Poth, Aaron G., Mylne, Joshua S., Grassl, Julia, Lyons, Russell E., Millar, A. Harvey, Colgrave, Michelle L. and Craik, David J. (2012). Cyclotides associate with leaf vasculature and are the products of a novel precursor in Petunia (Solanaceae). Journal of Biological Chemistry, 287 (32) 27033-27046. doi:10.1074/jbc.M112.370841
Schroeder, Christina I. and Craik, David J. (2012). Therapeutic potential of conopeptides. Future Medicinal Chemistry, 4 (10) 1243-1255. doi:10.4155/FMC.12.70
Thorstholm, L. and Craik, D. J. (2012). Discovery and applications of naturally occurring cyclic peptides. Drug Discovery Today: Technologies, 9 (1) e13-e21. doi:10.1016/j.ddtec.2011.07.005
Zhu, Shunyi, Gao, Bin, Harvey, Peta J. and Craik, David J. (2012). Dermatophytic defensin with antiinfective potential. Proceedings of the National Academy of Sciences of the United States of America, 109 (22) 8495-8500. doi:10.1073/pnas.1201263109
Yu, Rilei, Kaas, Quentin and Craik, David J. (2012). Delineation of the unbinding pathway of alpha-conotoxin Iml from the a7 nicotinic acetylcholine receptor. The Journal of Physical Chemistry B, 116 (21) 6097-6105. doi:10.1021/jp301352d
Henriques, Sonia Troeira and Craik, David J. (2012). Importance of the cell membrane on the mechanism of action of cyclotides. ACS Chemical Biology, 7 (4) 626-636. doi:10.1021/cb200395f
Clark, Richard J., Akcan, Muharrem, Kaas, Quentin, Daly, Norelle L. and Craik, David J. (2012). Cyclization of conotoxins to improve their biopharmaceutical properties. Toxicon, 59 (4) 446-455. doi:10.1016/j.toxicon.2010.12.003
Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2012). Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38). Current Pharmaceutical Design, 18 (8) doi:10.2174/138161212799315858
Craik, David J., Swedberg, Joakim E., Mylne, Joshua S. and Cemazar, Masa (2012). Cyclotides as a basis for drug design. Expert Opinion On Drug Discovery, 7 (3) 179-194. doi:10.1517/17460441.2012.661554
Craik, David J. (2012). Host-defense activities of cyclotides. Toxins, 4 (2) 139-156. doi:10.3390/toxins4020139
Franco, Aldo, Kompella, Shiva N., Akondi, Kalyana B., Melaun, Christian, Daly, Norelle L., Luetje, Charles W., Alewood, Paul F., Craik, David J., Adams. David J. and Mari, Frank (2012). RegIIA: An alpha 4/7-conotoxin from the venom of Conus regius that potently blocks alpha 3 beta 4 nAChRs. Biochemical Pharmacology, 83 (3) 419-426. doi:10.1016/j.bcp.2011.11.006
Pinto, Michelle F. S., Fensterseifer, Isabel C. M., Migliolo, Ludovico, Sousa, Daniel A., de Capdville, Guy, Arboleda, Jorge W., Colgrave, Michelle, Craik, David J., Magalhaes, Beatriz S., Dias, Simoni C. and Franco, Octavio L. (2012). Identification and structural characterization of a novel cyclotide with activity against an insect pest of sugar cane. The Journal of Biological Chemistry, 287 (1) 134-147. doi:10.1074/jbc.M111.294009
Kaas, Quentin, Yu, Rilei, Jin, Ai-Hua, Dutertre, Sebastien and Craik, David J. (2012). ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research, 40 (D1) D325-D330. doi:10.1093/nar/gkr886
Clark, Richard J. and Craik, David J. (2012). Engineering cyclic peptide toxins. Methods in Enzymology, 50357-74. doi:10.1016/B978-0-12-396962-0.00003-3
Schroeder, Christina I., Nielsen, Katherine J., Adams, Denise A., Loughnan, Marion L., Thomas, Linda, Alewood, Paul F., Lewis, Richard J. and Craik, David J. (2012). Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers, 98 (4) 345-356. doi:10.1002/bip.22031
Andersson, Hakan S., Figueredo, Sharel M., Haugaard-Kedstrom, Linda M., Bengtsson, Elina, Daly, Norelle L., Qu, Xiaoqing, Craik, David J., Ouellette, Andre J. and Rosengren, K. Johan (2012). The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids, 43 (4) 1471-1483. doi:10.1007/s00726-012-1220-3
Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2011). Engineering of conotoxins for the treatment of pain. Current Pharmaceutical Design, 17 (38) 4242-4253. doi:10.2174/138161211798999401
Sando, Lillian, Henriques, Sonia Troeira, Foley, Fiona, Simonsen, Shane M., Daly, Norelle L., Hall, Kristopher N., Gustafson, Kirk R., Aguilar, Marie-Isabel and Craik, David J. (2011). A synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor. ChemBioChem, 12 (16) 2456-2462. doi:10.1002/cbic.201100450
Conibear, Anne C. and Craik, David J. (2011). Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals. Israel Journal of Chemistry, 51 (8-9) 908-916. doi:10.1002/ijch.201100067
Smith, Amanda B., Daly, Norelle L. and Craik, David J. (2011). Cyclotides: A patent review. Expert Opinion On Therapeutic Patents, 21 (11) 1657-1672. doi:10.1517/13543776.2011.620606
Chan, Lai Y., Gunasekera, Sunithi, Henriques, Sonia T., Worth, Natalie F., Le, Sarah-Jane, Clark, Richard J., Campbell, Julie H., Craik, David J. and Daly, Norelle L. (2011). Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds. Blood, 118 (25) 6709-6717. doi:10.1182/blood-2011-06-359141
Halai, Reena, Callaghan, Brid, Daly, Norelle L., Clark, Richard J., Adams, David J. and Craik, David J. (2011). Effects of cyclization on stability, structure, and activity of alpha-conotoxin RgIA at the alpha 9 alpha 10 nicotinic acetylcholine receptor and GABA(B) receptor. Journal of Medicinal Chemistry, 54 (19) 6984-6992. doi:10.1021/jm201060r
Dekan, Zoltan, Vetter, Irina, Daly, Norelle L., Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2011). α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Journal of the American Chemical Society, 133 (40) 15866-15869. doi:10.1021/ja206408q
He, Wenjun, Chan, Lai Yue, Zeng, Guangzhi, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2011). Isolation and characterization of cytotoxic cyclotides from Viola philippica. Peptides, 32 (8) 1719-1723. doi:10.1016/j.peptides.2011.06.016
Dantas de Araujo, Aline, Callaghan, Brid, Nevin, Simon T., Daly, Norelle L., Craik, David J., Moretta, Melissa, Hopping, Gene, Christie, Macdonald J., Adams, David J. and Alewood, Paul F. (2011). Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie (International Edition), 50 (29) 6527-6529. doi:10.1002/anie.201101642
Henriques, Sónia Troeira, Huang, Yen-Hua, Rosengren, K. Johan, Franquelim, Henri G., Carvalho, Filomena A., Johnson, Adam, Sonza, Secondo, Tachedjian, Gilda, Castanho, Miguel A. R. B., Daly, Norelle L. and Craik, David J. (2011). Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. Journal of Biological Chemistry, 286 (27) 24231-24241. doi:10.1074/jbc.M111.253393
Poth, Aaron G., Colgrave, Michelle L., Lyons, Russell E., Daly, Norelle L. and Craik, David J. (2011). Discovery of an unusual biosynthetic origin for circular proteins in legumes. Proceedings of the National Academy of Sciences of the United State of America, 108 (25) 10127-10132. doi:10.1073/pnas.1103660108
Craik, David J. and Conibear, Anne C. (2011). The chemistry of cyclotides. Journal of Organic Chemistry, 76 (12) 4805-4817. doi:10.1021/jo200520v
Yuan, Cai, Chen, Liqing, Meehan, Edward J., Daly, Norelle, Craik, David J., Huang, Mingdong and Ngo, Jacky C. (2011). Structure of catalytic domain of matriptase in complex with sunflower trypsin inhibitor-1. BMC Structural Biology, 11 (30) 30, 30-1-30-10. doi:10.1186/1472-6807-11-30
Daly, Norelle L. and Craik, David J. (2011). Bioactive cystine knot proteins. Current Opinion in Chemical Biology, 15 (3) 362-368. doi:10.1016/j.cbpa.2011.02.008
Mylne, Joshua S., Colgrave, Michelle L., Daly, Norelle L., Chanson, Aurelie H., Elliott, Alysha G., McCallum, Emily J., Jones, Alun and Craik, David J. (2011). Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nature Chemical Biology, 7 (5) 257-259. doi:10.1038/nchembio.542
Wang, Conan K. L., Clark, Richard J., Harvey, Peta J., Rosengren, K. Johan, Cemazar, Masa and Craik, David J. (2011). The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry, 50 (19) 4077-4086. doi:10.1021/bi2004153
Haugaard-Kedström, Linda M., Shabanpoor, Fazel, Hossain, Mohammed Akhter, Clark, Richard J., Ryan, Philip J., Craik, David J., Gundlach, Andrew L., Wade, John D., Bathgate, Ross A. D. and Rosengren, K. Johan (2011). Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3. Journal of the American Chemical Society, 133 (13) 4965-4974. doi:10.1021/ja110567j
Daly, Norelle L., Rosengren, K. Johan, Henriques, Sonia Troeira and Craik, David J. (2011). NMR and protein structure in drug design: Application to cyclotides and conotoxins. European Biophysics Journal, 40 (4) 359-370. doi:10.1007/s00249-011-0672-9
Poth, Aaron G., Colgrave, Michelle L., Philip, Reynold, Kerenga, Bomai, Daly, Norelle L., Anderson, Marilyn A. and Craik, David J. (2011). Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chemical Biology, 6 (4) 345-355. doi:10.1021/cb100388j
Yu, Rilei, Craik, David J. and Kaas, Quentin (2011). Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Computational Biology, 7 (3) e1002011, e1002011-1-e1002011-16. doi:10.1371/journal.pcbi.1002011
Daly, Norelle L., Callaghan, Brid, Clark, Richard J., Nevin, Simon T., Adams, David J. and Craik, David J. (2011). Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels. Journal of Biological Chemistry, 286 (12) 10233-10237. doi:10.1074/jbc.M110.196170
Clark, Richard J., Tan, Chia Chia, Preza, Gloria C., Nemeth, Elizabeta, Ganz, Tomas and Craik, David J. (2011). Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chemistry and Biology, 18 (3) 336-343. doi:10.1016/j.chembiol.2010.12.009
Akcan, M, Stroud, MR, Hansen, SJ, Clark, RJ, Daly, NL, Craik, DJ and Olson, JM (2011). Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy. Journal of Medicinal Chemistry, 54 (3) 782-787. doi:10.1021/jm101018r
Craik, David J. (2011). The folding of disulfide-rich proteins. Antioxidants and Redox Signaling, 14 (1) 61-64. doi:10.1089/ars.2010.3656
Aboye, Teshome Leta, Clark, Richard J., Burman, Robert, Roig, Marta Bajona, Craik, David J. and Goransson, Ulf (2011). Interlocking Disulfides in Circular Proteins: Toward Efficient Oxidative Folding of Cyclotides. Antioxidants & Redox Signaling, 14 (1) 77-86. doi:10.1089/ars.2010.3112
Lovelace, Erica S., Gunasekera, Sunithi, Alvarmo, Charlotta, Clark, Richard J., Nevin, Simon T., Grishin, Anton A., Adams, David J., Craik, David J. and Daly, Norelle L. (2011). Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization. Antioxidants and Redox Signaling, 14 (1) 87-95. doi:10.1089/ars.2009.3068
Daly, N. L. and Craik, David J. (2011). Conopeptides as novel options for pain management. Drugs of the Future, 36 (1) 25-32. doi:10.1358/dof.2011.36.1.1561066
Cascales, Laura, Henriques, Sónia T., Kerr, Markus C., Huang, Yen-Hua, Sweet, Matthew J., Daly, Norelle L. and Craik, David J. (2011). Identification and characterization of a new family of cell penetrating peptides: Cyclic cell penetrating peptides. Journal of Biological Chemistry, Epub ahead of print (42) 36932-36943. doi:10.1074/jbc.M111.264424
Craik, David J. (2010). Discovery and applications of the plant cyclotides. Toxicon, 56 (7) 1092-1102. doi:10.1016/j.toxicon.2010.02.021
Cascales, Laura and Craik, David J. (2010). Naturally occurring circular proteins: Distribution, biosynthesis and evolution. Organic and Biomolecular Chemistry, 8 (22) 5035-5047. doi:10.1039/c0ob00139b
Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010). Isolation and characterization of Bioactive Cyclotides from Viola labrilorica. Helvetica Chimica Acta, 93 (11) 2287-2295. doi:10.1002/hlca.201000115
Rosengren, K. Johan and Craik, David J. (2010). Peptide rope tricks. Chimica Oggi, 28 (6) 28-32.
Henriques, Sonia Troeira, Tan, Chia Chia, Craik, David J. and Clark, Richard J. (2010). Structural and functional analysis of human liver-expressed antimicrobial peptide 2. ChemBioChem, 11 (15) 2148-2157. doi:10.1002/cbic.201000400
Ireland, David C., Clark, Richard J., Daly, Norelle L. and Craik, David J. (2010). Isolation, sequencing, and structure - Activity relationships of cyclotides. Journal of Natural Products, 73 (9) 1610-1622. doi:10.1021/np1000413
Morales, Rodrigo A. V., Daly, Norelle L., Vetter, Irina, Mobli, Mehdi, Napier, Ian A., Craik, David J., Lewis, Richard J., Christie, MacDonald J., King, Glenn F., Alewood, Paul F. and Durek, Thomas (2010). Chemical synthesis and structure of the prokineticin Bv8. ChemBioChem, 11 (13) 1882-1888. doi:10.1002/cbic.201000330
Clark, Richard J., Jensen, Jonas, Nevin, Simon T., Callaghan, Brid P., Adams, David J. and Craik, David J. (2010). The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angewandte Chemie (International Edition), 49 (37) 6545-6548. doi:10.1002/anie.201000620
Dunse, K. M., Kaas, Q., Guarino, R. F., Barton, P. A., Craik, D. J. and Anderson, M. A. (2010). Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America., 107 (34) 15016-15021. doi:10.1073/pnas.1009327107
Moloney, Gerard P., Iskander, Magdy N. and Craik, David J. (2010). Stability studies of oxazolidine-based compounds using 1H NMR spectroscopy. Journal of Pharmaceutical Sciences, 99 (8) 3362-3371. doi:10.1002/jps.22108
Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010). Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 31 (8) 1434-1440. doi:10.1016/j.peptides.2010.05.004
Kaas, Quentin, Westermann, Jan-Christoph and Craik, David J. (2010). Conopeptide characterization and classifications: An analysis using ConoServer. Toxicon, 55 (8) 1491-1509. doi:10.1016/j.toxicon.2010.03.002
Colgrave, Michelle L., Huang, Yen-Hua, Craik, David J. and Kotze, Andrew C. (2010). Cyclotide interactions with the nematode external surface. Antimicrobial Agents and Chemotherapy, 54 (5) 2160-2166. doi:10.1128/AAC.01306-09
Luo, Sulan, Akondi, Kalyana Bharati, Zhangsun, Dongting, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Christensen, Sean, Dowell, Cheryl, Daly, Norelle L., Craik, David J., Wang, Ching-I. Anderson, Lewis, Richard J., Alewood, Paul F. and McIntosh, J. Michael (2010). Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha 3 beta 2 nicotinic receptor. Journal of Biological Chemistry, 285 (16) 12355-12366. doi:10.1074/jbc.M109.079012
Huang, Yen-Hua (黃彥華), Colgrave, Michelle L., Clark, Richard J., Kotze, Andrew C. and Craik, David J. (2010). Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. Journal of Biological Chemistry, 285 (14) 10797-10805. doi:10.1074/jbc.M109.089854
Armishaw, Christopher J., Dutton, Julie L., Craik, David J. and Alewood, Paul F. (2010). Establishing regiocontrol of disulfide bond isomers of alpha-conotoxin ImI via the synthesis of N-to-C cyclic analogues. Biopolymers: Peptide Science, 94 (3) 307-313. doi:10.1002/bip.21360
Muttenthaler, Marcus, Nevin, Simon T., Grishin, Anton A., Ngo, Shyuan T., Choy, Peng T., Daly, Norelle L., Hu, Shu-Hong, Armishaw, Christopher J., Wang, Ching-I. A., Lewis, Richard J., Martin, Jennifer L., Noakes, Peter G., Craik, David J., Adams, David J. and Alewood, Paul F. (2010). Solving the alpha-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists. Journal of the American Chemical Society, 132 (10) 3514-3522. doi:10.1021/ja910602h
Qin, Qiaoping, McCallum, Emily J., Kaas, Quentin, Suda, Jan, Saska, Ivana, Craik, David J. and Mylne, Joshua S. (2010). Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis. BMC Genomics, 11 (111) 111, 1-11. doi:10.1186/1471-2164-11-111
Plan, Manuel R, Rosengren, K Johan, Sando, Lillian, Daly, Norelle L and Craik, David J (2010) Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis. Biopolymers, 94 5: 647-658. doi:10.1002/bip.21409
Mylne, Joshua S, Wang, Conan K, van der Weerden, Nicole L and Craik, David J (2010) Cyclotides are a component of the innate defense of Oldenlandia affinis. Biopolymers, 94 5: 635-646. doi:10.1002/bip.21419
Kaas, Quentin and Craik, David J (2010) Analysis and classification of circular proteins in CyBase. Biopolymers, 94 5: 584-591. doi:10.1002/bip.21424
Craik, David J. (2010). Forward for ICCP2009 issue of Biopolymers Peptide Science. Biopolymers, 94 (5) iii-v. doi:10.1002/bip.21509
Craik, David J., Mylne, Joshua S. and Daly, Norelle L. (2010). Cyclotides: Macrocyclic peptides with applications in drug design and agriculture. Cellular and Molecular Life Sciences, 67 (1) 9-16. doi:10.1007/s00018-009-0159-3
Burman, Robert, Gruber, Christian W., Rizzardi, Kristina, Herrmann, Anders, Craik, David J., Gupta, Mahabir P. and Goransson, Ulf (2010). Cyclotide proteins and precursors from the genus Gloeospermum: Filling a blank spot in the cyclotide map of Violaceae. Phytochemistry, 71 (1) 13-20. doi: