Researcher biography

A/Prof Ben Hogan completed his Honours year in Genetics in 2000 and PhD in 2004 at the University of Melbourne. During his PhD studies and as a Cancer Council postdoctoral fellow at the Ludwig Institute in Melbourne, Ben utilised the zebrafish model to study the development of the early haematopoietic lineages in the embryo. In 2006, Ben moved to the Hubrecht Institute in the Netherlands and applied large-scale zebrafish forward genetic screening to study vascular development. In the first vertebrate mutagenesis screen for lymphatic vascular deficient mutants, several new molecular regulators of lymphatic development were identified, including Ccbe1, later found to be responsible for lymphatic dysplasia and lymphoedema in Hennekam syndrome patients. In 2010, Ben returned to Australia as a group leader at the Institute for Molecular Bioscience. A/Prof Hogan's research has since led to the discovery of a number of unexpected new molecular regulators of vascular development, defined the mechanism of Ccbe1 function in vascular signaling and delved into the cellular behaviours that control vessel morphogenesis during embryonic development. The Hogan lab remains focused on understanding the process of vascular development in the vertebrate embryo with an emphasis on the developmental biology of understudied lineages including perivascular lineages and the lymphatic vasculature.