My lab is currently focusing on the reasons why cholinergic neurons of the basal forebrain die in Alzheimer’s disease, what contribution their loss makes to cognitive decline and whether manipulating neurotrophic signalling  (NGF, BDNF, TrkA/B, p75) can protect or restore cognitive function, and what role the neurotrophins play in the normal function of these neurons.

The lab is supported by:

  • National Health and Medical Research Council of Australia (NHMRC)
  • Alzheimer’s Research UK
  • Motor Neuron Disease Research Institute of Australia (MNDRI)
  • Clem Jones Centre for Aging Dementia Research (CJCADR)
  • Mason Foundation (Perpetual Trustees)