Ng Lab - Publications
2016
Fife, C.M., Sagnellla, S.M., Teo, W.S., Po'uha, S.T., Byrne, F.L., Yeap, Y.Y., Ng, D.C.H., Davis, T.P., McCarroll, J.A. and Kavallaris, M. 2016
Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.
Oncogene, doi: 10.1038/onc.2016.220.
Hoque, A., Hossain, M.I., Ameen, S., Ang, C-S., Williamson, N.A., Ng, D.C.H., Chueh, A.C., Roulston, C. and Cheng, H-C. 2016.
A Beacon of Hope in Stroke Therapy – Blockade of Pathological Cellular Events Leading to Excitotoxic Neuronal Death as a Neuroprotective Strategy.
Pharmacol Ther, 160, 159-79. Review
Lim, N.R., Yeap, Y.Y., Ang, C-S., Williamson, N.A., Bogoyevitch, M.A., Quinn, L.M. and Ng, D.C.H. 2016.
Aurora A phosphorylation of WD40-repeat protein 62 for mitotic spindle regulation.
Cell Cycle, 15:413-424
2015
Birnie, K.A., Yip, Y.Y., Ng, D.C.H., Kirschner, M.B., Reid, G., Prele, C.M., Musk, A.W., Lee, Y.G., Thompson, P.J., Mutsaers, S.E. and Badrian, B. 2015.
Loss of mir-223 and JNK Signalling Contribute to Elevated Stathmin in Malignant Pleural Mesothelioma.
Mol Cancer Res. 13:1106-1118.
Thomas, C.J., Lim, N.R., Kedikaetswe, A., Yeap, Y.Y., Woodman, O.L., Ng, D.C.H. and May, C.N. 2015.
Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3',4'-dihydroxyflavonol.
Eur J Pharmacol. 758:53-59.
Bell, J.R., Raaijmakers, A. J., Curl, C.L., Reichelt, M.E., Harding, T.W., Bei, A., Ng, D.C.H., Erickson, J.R., Vila Petroff, M., Harrap, S.B. & Delbridge, L.M. 2015.
Cardiac CaMKIIdelta splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart.
Int J Cardiol, 181, 288-96.
Lim, N.R., Yeap, Y.Y., Zhao, T.T., Yip, Y.Y., Wong, S.C., Xu, D., Ang, C.S., Williamson, N.A., Xu, Z., Bogoyevitch, M.A. & Ng, D.C.H. 2015.
Opposing roles for JNK and Aurora A in regulating WD40-Repeat Protein 62 association with spindle microtubules.
J Cell Sci, 128, 527-540
Iqbal Hossain, M., Hoque, A., Lessene, G., Aizuddin Kamaruddin, M., Chu, P.W., Ng, I.H., Irtegun, S., Ng, D.C.H., Bogoyevitch, M.A., Burgess, A.W., Hill, A.F. & Cheng, H-C. 2015.
Dual role of Src kinase in governing neuronal survival.
Brain Res, 1594, 1-14.
2014
Yip, Y.Y., Yeap, Y.Y., Bogoyevitch, M.A. & Ng, D.C.H. 2014.
cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.
J Biol Chem, 289, 2157-69.
Yip, Y.Y., Yeap, Y.Y., Bogoyevitch, M.A. & Ng, D.C.H. 2014.
Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members.
Biochem Biophys Res Commun, 446, 248-54.
Misheva, M., Kaur, G., Ngoei, K.R., Yeap, Y.Y., Ng, I.H., Wagstaff, K.M., Ng, D. C. H., Jans, D.A. & Bogoyevitch, M. A. 2014.
Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress.
Biochim Biophys Acta, 1843, 253-64.
2013
Lim, N.R., Thomas, C.J., Silva, L.S., Yeap, Y.Y., Yap, S., Bell, J.R., Delbridge, L.M., Bogoyevitch, M.A., Woodman, O.L., Williams , S.J., May, C.N. and Ng, D.C.H. 2013.
Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition.
Biochem J, 456, 149-61.
Hossain, M.I., Roulston, C.L., Kamaruddin, M.A., Chu, P.W., Ng, D.C.H., Dusting, G.J., Bjorge, J.D., Williamson, N.A., Fujita, D.J., Cheung, S.N., Chan, T.O., Hill, A.F. and Cheng, H-C. 2013.
A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.
J Biol Chem, 288, 9696-709.
Ngoei, K.R., Ng, D.C.H., Gooley, P.R., Fairlie, D.P., Stoermer, M.J. and Bogoyevitch, M.A. 2013.
Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds.
Biochim Biophys Acta, 1834, 1077-88.
2012
Ng, I.H., Ng, D.C.H., Jans, D.A. and Bogoyevitch, M.A. 2012.
Selective STAT3-alpha or -beta expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes.
Biochem J, 447, 125-36.
Bogoyevitch, M.A., Yeap, Y.Y., Qu, Z., Ngoei, K.R., Yip, Y.Y., Zhao, T.T., Heng, J.I. and Ng, D.C.H. 2012.
WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression.
J Cell Sci, 125, 5096-109.
Ramdzan, Y.M., Polling, S., Chia, C.P., Ng, I.H., Ormsby, A.R., Croft, N.P., Purcell, A.W., Bogoyevitch, M.A., Ng, D.C.H., Gleeson, P.A. and Hatters, D.M. 2012.
Tracking protein aggregation and mislocalization in cells with flow cytometry.
Nat Methods, 9, 467-70.
Ng, D.C.H. and Byrne, F. 2012.
“Stathmin and cancer.” Chapter 14, 259-284. Book Title: The Cytoskeleton and Human Disease. Kavallaris M. [Ed.]. Spinger Press, NY, USA.
2011
Meyerowitz, J., Parker, S.J., Vella, L.J., Ng, D.C.H., Price, K.A., Liddell, J.R., Caragounis, A., Li, Q.X., Masters, C.L., Nonaka, T., Hasegawa, M., BOogoyevitch, M.A., Kanninen, K.M., Crouch, P.J. and White, A.R. 2011.
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress.
Mol Neurodegener, 6, 57.
Waardenberg, A.J., Bernardo, B.C., Ng, D.C.H., Shepherd, P.R., Cemerlang, N., Sbroggio, M., Wells, C. A., Dalrymple, B.P., Brancaccio, M., Lin, R.C. and McMullen, J.R. 2011.
Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure.
J Biol Chem, 286, 30837-46.
Thomas, C.J., Ng, D.C.H., Patsikatheodorou, N., Limengka, Y., Lee, M.W., Darby, I.A., Woodman, O. L. and May, C.N. 2011.
Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK.
Eur J Pharmacol, 658, 160-7.
Ngoei, K.R., Catimel, B., Church, N., Lio, D.S., Dogovski, C., Perugini, M.A., Watt, P.M., Cheng, H-C., Ng, D.C.H. and Bogoyevitch, M.A. 2011.
Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide.
Biochem J, 434, 399-413.
Ng, D.C.H., Ng, I.H., Yeap, Y.Y., Badrian, B., Tsoutsman, T., McMullen, J.R., Semsarian, C. and Bogoyevitch, M.A. 2011.
Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy.
J Biol Chem, 286, 1576-87.
2010
Ng, D.C.H., Zhao, T.T., Yeap, Y.Y., Ngoei, K.R. and Bogoyevitch, M.A. 2010.
c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress.
J Biol Chem, 285, 29001-13.
Yeap, Y.Y., Ng, I.H., Badrian, B., Nguyen, T.V., Yip, Y.Y., Dhillon, A.S., Mutsaers, S.E., Silke, J., Bogoyevitch, M.A. and Ng, D.C.H. 2010.
c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18.
Biochem J, 430, 345-54.
Ng, D.C.H., Lim, C.P., Lin, B.H., Zhang, T. and Cao, X. 2010.
SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells.
Biochem J, 425, 95-105.
Bogoyevitch, M.A., Ngoei, K.R., Zhao, T.T., Yeap, Y.Y. and Ng, D.C.H. 2010.
c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.
Biochim Biophys Acta, 1804, 463-75. Review