Integrated Physiology Facility
The IPF is well equipped for in vivo animal physiology studies with capabilities for complex phenotyping, telemetry and surgery.
Equipment is listed below. Please browse our fees.
TSE Phenomaster
The Phenomaster is a versatile phenotyping system. Up to 16 animals are individually housed in standard cage bottoms, inside environmentally controlled chambers. The two environmentally controlled chambers can operate independently and control light intensity, temperature and humidity. The monitoring equipment around each cage simultaneously records food and drink consumption, body weight, activity, oxygen consumption and CO2 production. Implanted telemetry equipment can also be incorporated within the Phenomaster further expanding its capabilities as required. Indirect calorimetry for metabolic studies can be performed by using the measurement of O2 consumption and CO2 production. The monitoring equipment can also be programmed to automatically restrict access to food and to pair feed either single or groups of animals. Running wheels can similarly be programmed to operate freely or under restricted access.
For enquires regarding capabilities and bookings please contact Melanie Flint.
Please browse the fees for this facility.
Buker Minispec NMR analyser
The NMR analyser measures total body fat and lean mass in conscious mice. The procedure is fast and causes no deleterious effects to the mice allowing the measurements to be repeated on the one animal over a period of time if required.
For enquires please contact Melanie Flint.
Surgical facility
The surgical facility is well equipped and can be adapted for a wide variety of procedures. The anaesthetic equipment includes oxygen, isoflurane vaporizers, minivet ventilators and a pulse ox for monitoring animals. The surgical microscope assists in the teaching of procedures as it is connected to a television and has the capacity to take still photos and videos. Animals awaiting surgery can be housed in the animal holding facility and animals recovering from surgery can be supported in the warmth of the climate controlled Memmert chambers.
For enquires please contact Melanie Flint.
Memmert chambers
The two programmable environment controlled Memmert chambers operate independently and control light intensity, temperature and humidity. These cabinets are effective in providing a warm environment for animals recovering from surgery.
For enquires please contact Melanie Flint.
Short term mouse holding facility
The facility has the capacity to hold mice for short term use with in the facility and while acclimatizing to the monitoring systems used in the Phenomaster.
For enquires please contact Melanie Flint.
Echocardiography machine
- Detailed assessment of systolic and diastolic function
- Quantification of cardiac changes resulting from myocardial infarct in adults and neonates
- Assessment of function in response to transverse aortic constriction and abdominal aortic constriction-induced cardiac hypertrophy
- Assessment of excess angiotensin (pressor, sub pressor)-induced hypertension and hypertrophy
- Assessment of exercise-induced hypertrophy-associated cardiac changes
- Examination of cardiac function and organ development in developing mice in utero
- Integration of ECG analysis with cardiac function
- Pressure volume loop analysis (using Millar catheters)
Contact
For all enquiries, please contact Melanie Flint.