Book Chapters
Barclay, Chris J. (2019). Efficiency of skeletal muscle. Muscle and exercise physiology. (pp. 111-127) edited by Jerzy A. Zoladz. London, United Kingdom : Academic Press. doi: 10.1016/b978-0-12-814593-7.00006-2
Barclay, C. J. and Widén, C. (2010). Efficiency of cross-bridges and mitochondria in mouse cardiac muscle. Muscle biophysics: from molecules to cells. (pp. 267-278) New York, NY USA: Springer. doi: 10.1007/978-1-4419-6366-6_15
Journal Articles
Barclay, C.J. and Curtin, N.A. (2023). Advances in understanding the energetics of muscle contraction. Journal of Biomechanics, 156 111669, 1-11. doi: 10.1016/j.jbiomech.2023.111669
Curtin, N.A. and Barclay, C.J. (2023). The energetics of muscle contractions resembling in vivo performance. Journal of Biomechanics, 156 111665, 1-9. doi: 10.1016/j.jbiomech.2023.111665
Barclay, C. J. (2022). A century of exercise physiology: key concepts in muscle energetics. European Journal of Applied Physiology, 123 (1), 25-42. doi: 10.1007/s00421-022-05070-7
Barclay, Christopher J. and Launikonis, Bradley S. (2022). Erratum: Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers (The Journal of general physiology (2022) 154 9 PII: e20211299404062022c). The Journal of general physiology, 154 (9) e20211299404062022c. doi: 10.1085/jgp.20211299404062022c
Barclay, Chris J. and Curtin, Nancy A. (2022). The legacy of A. V. Hill's Nobel Prize winning work on muscle energetics. The Journal of Physiology, 600 (7), 1555-1578. doi: 10.1113/jp281556
Barclay, Christopher J. and Launikonis, Bradley S. (2022). A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers. Journal of General Physiology, 154 (9) e202112994. doi: 10.1085/jgp.202112994
Meizoso-Huesca, Aldo, Pearce, Luke, Barclay, Christopher J. and Launikonis, Bradley S. (2022). Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle. Proceedings of the National Academy of Sciences, 119 (4) e2119203119, 1-8. doi: 10.1073/pnas.2119203119
Lamboley, Cedric R., Pearce, Luke, Seng, Crystal, Meizoso-Huesca, Aldo, Singh, Daniel P., Frankish, Barnaby P., Kaura, Vikas, Lo, Harriet P., Ferguson, Charles, Allen, Paul D., Hopkins, Philip M., Parton, Robert G., Murphy, Robyn M., van der Poel, Chris, Barclay, Christopher J. and Launikonis, Bradley S. (2021). Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances, 7 (44) eabi7166, 1-15. doi: 10.1126/sciadv.abi7166
Barclay, C. J. and Loiselle, D. S. (2021). Historical perspective: heat production and chemical change in muscle. Roger C. Woledge. Progress in Biophysics and Molecular Biology, 161, 3-16. doi: 10.1016/j.pbiomolbio.2021.01.002
Rushton, Carole and Barclay, Chris (2021). Hoist by his own petard: a rejoinder to Contandriopoulos. Nursing Inquiry, 28 (2) e12404. doi: 10.1111/nin.12404
Barclay, Christopher John and Loiselle, Denis Scott (2020). An equivocal final link – quantitative determination of the thermodynamic efficiency of ATP hydrolysis – sullies the chain of electric, ionic, mechanical and metabolic steps underlying cardiac contraction. Frontiers in Physiology, 11 183. doi: 10.3389/fphys.2020.00183
Barclay, C. J. and Launikonis, B. S. (2019). Components of activation heat in skeletal muscle. Journal of Muscle Research and Cell Motility, 42 (1), 1-16. doi: 10.1007/s10974-019-09547-5
Loiselle, Denis S. and Barclay, Christopher J. (2018). The ineluctable constraints of thermodynamics in the aetiology of obesity. Clinical and Experimental Pharmacology and Physiology, 45 (3), 219-225. doi: 10.1111/1440-1681.12869
Barclay, Christopher J. (2017). The basis of differences in thermodynamic efficiency among skeletal muscles. Clinical and Experimental Pharmacology and Physiology, 44 (12), 1279-1286. doi: 10.1111/1440-1681.12850
Barclay, C. J. (2017). Energy demand and supply in human skeletal muscle. Journal of Muscle Research and Cell Motility, 38 (2), 143-155. doi: 10.1007/s10974-017-9467-7
Bakker, Anthony J., Cully, Tanya R., Wingate, Catherine D., Barclay, Christopher J. and Launikonis, Bradley S. (2017). Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. Journal of General Physiology, 149 (3), 323-334. doi: 10.1085/jgp.201611727
Loiselle, Denis S., Han, June-Chiew, Goo, Eden, Chapman, Brian, Barclay, Christopher J., Hickey, Anthony J. R. and Taberner, Andrew J. (2016). Thermodynamic analysis questions claims of improved cardiac efficiency by dietary fish oil. Journal of General Physiology, 148 (3), 183-193. doi: 10.1085/jgp.201611620
Barclay, Chris and Curtin, Nancy (2015). Roger C. Woledge 1938-2015. Journal of Muscle Research and Cell Motility, 36 (4-5), 301-303. doi: 10.1007/s10974-015-9417-1
Barclay, C. J. (2015). A mathematical model of heat flow in a thermopile for measuring muscle heat production: implications for design and signal analysis. Physiological Measurement, 36 (9) 1853, 1853-72. doi: 10.1088/0967-3334/36/9/1853
Barclay, C. J. (2015). Energetics of contraction. Comprehensive Physiology, 5 (2), 961-95. doi: 10.1002/cphy.c140038
Lewis, D. B. and Barclay, C. J. (2014). Efficiency and cross-bridge work output of skeletal muscle is decreased at low levels of activation. Pflugers Archiv, 466 (3), 599-609. doi: 10.1007/s00424-013-1344-7
Barclay, C. J. (2012). Quantifying Ca2+ release and inactivation of Ca2+ release in fast- and slow-twitch muscles. Journal of Physiology, 590 (23), 6199-6212. doi: 10.1113/jphysiol.2012.242073
Lichtwark, G. A. and Barclay, C. J. (2012). A compliant tendon increases fatigue resistance and net efficiency during fatiguing cyclic contractions of mouse soleus muscle. Acta Physiologica, 204 (4), 533-543. doi: 10.1111/j.1748-1716.2011.02361.x
Cannata, David J., Crossley, Kelly J., Barclay, Chris J., Walker, David W. and West, Jan M. (2011). Contribution of stretch to the change of activation properties of muscle fibers in the diaphragm at the transition from fetal to neonatal life. Frontiers in Physiology, 2 DEC 109. doi: 10.3389/fphys.2011.00109
Barclay, C. J., Woledge, R. C. and Curtin, N. A. (2010). Is the efficiency of mammalian (mouse) skeletal muscle temperature dependent?. Journal of Physiology, 588 (19), 3819-3831. doi: 10.1113/jphysiol.2010.192799
Park-Holohan, S. -J., West, T. G., Woledge, R. C., Ferenczi, M. A., Barclay, C. J. and Curtin, N. A. (2010). Effect of phosphate and temperature on force exerted by white muscle fibres from dogfish. Journal of Muscle Research and Cell Motility, 31 (1), 35-44. doi: 10.1007/s10974-010-9198-5
Lichtwark, G. A. and Barclay, C. J. (2010). The influence of tendon compliance on muscle power output and efficiency during cyclic contractions. Journal of Experimental Biology, 213 (5), 707-714. doi: 10.1242/jeb.038026
Barclay, C. J., Woledge, R. C. and Curtin, N. A. (2010). Inferring crossbridge properties from skeletal muscle energetics. Progress in Biophysics & Molecular Biology, 102 (1), 53-71. doi: 10.1016/j.pbiomolbio.2009.10.003
Woledge, R. C., Barclay, C. J. and Curtin, N. A. (2009). Temperature change as a probe of muscle crossbridge kinetics: a review and discussion. Proceedings of the Royal Society B - Biological Sciences, 276 (1668), 2685-2695. doi: 10.1098/rspb.2009.0177
Loiselle, D. S., Crampin, E. J., Niederer, S. A., Smith, N. P. and Barclay, C. J. (2009). Erratum to: "Energetic consequences of mechanical loads" [J. Biophys. Mol. Biol. 97 (2008) 348-366] (DOI:10.1016/j.pbiomolbio.2008.02.015). Progress in Biophysics and Molecular Biology, 99 (2-3), 114. doi: 10.1016/j.pbiomolbio.2009.02.002
Barclay, C. J., Woledge, R. C. and Curtin, N. A. (2009). Effects of UCP3 genotype, temperature and muscle type on energy turnover of resting mouse skeletal muscle. Pflugers Archiv: European Journal of Physiology, 457 (4), 857-864. doi: 10.1007/s00424-008-0552-z
Barclay, C. J. (2008). Getting energy to where it is required is a problem in the failing heart. The Journal of Physiology, 586 (21), 5037-5038. doi: 10.1113/jphysiol.2008.163246
Barclay, C. J., Lichtwark, G. A. and Curtin, N. A. (2008). The energetic cost of activation in mouse fast-twitch muscle is the same whether measured using reduced filament overlap or N-benzyl-p-toluenesulphonamide. Acta Physiologica, 193 (4), 381-391. doi: 10.1111/j.1748-1716.2008.01855.x
Loiselle, D. S., Crampin, E. J., Niederer, S. A., Smith, N. P. and Barclay, C. J. (2008). Energetic consequences of mechanical loads. Progress in Biophysics & Molecular Biology, 97 (2-3), 348-366. doi: 10.1016/j.pbiomolbio.2008.02.015
Barclay, C. J., Woledge, R. C. and Curtin, N. A. (2007). Energy turnover for Ca2+ cycling in skeletal muscle. Journal of Muscle Research and Cell Motility, 28 (4-5), 259-274. doi: 10.1007/s10974-007-9116-7
Barclay, C. J. and Lichtwark, G. A. (2007). The mechanics of mouse skeletal muscle when shortening during relaxation. Journal of Biomechanics, 40 (14), 3121-3129. doi: 10.1016/j.jbiomech.2007.03.024
Barclay, C. J. and Loiselle, D. S. (2007). Can activation account for 80% of skeletal muscle energy use during isometric contraction?. American Journal of Physiology: Cell Physiology, 292 (1), C612-C612. doi: 10.1152/ajpcell.00122.2006
Widen, C. and Barclay, C. J. (2006). ATP splitting by half the cross-bridges can explain the twitch energetics of mouse papillary muscle. The Journal of Physiology, 573 (1), 5-15. doi: 10.1113/jphysiol.2006.104992
Barclay, C. J. (2005). Maximum contractile filament movement per ATP used in muscle contraction is similar to 1.3 nm not 13 mn. International Journal of Biological Macromolecules, 37 (3), 154-155. doi: 10.1016/j.ijbiomac.2005.09.005
Barclay, C. J. (2005). Modelling diffusive O2 supply to isolated preparations of mammalian skeletal and cardiac muscle. Journal of Muscle Research and Cell Motility, 26 (4-5), 225-235. doi: 10.1007/s10974-005-9013-x
Widen, C. and Barclay, C. J. (2005). Resting metabolism of mouse papillary muscle. Pflugers Archiv: European Journal of Physiology, 450 (4), 209-216. doi: 10.1007/s00424-005-1408-4
Smith, Nicholas P., Barclay, Chris J. and Loiselle, Denis S. (2005). The efficiency of muscle contraction. Progress in Biophysics & Molecular Biology, 88 (1), 1-58. doi: 10.1016/j.pbiomolbio.2003.11.014
Barclay, C. J. and Weber, C. L. (2004). Slow skeletal muscles of the mouse have greater initial efficiency than fast muscles but the same net efficiency. The Journal of Physiology, 559 (2), 519-533. doi: 10.1113/jphysiol.2004.069096
Barclay, C. J. (2003). Models in which many cross-bridges attach simultaneously can explain the filament movement per ATP split during muscle contraction. International Journal of Biological Macromolecules, 32 (3-5), 139-147. doi: 10.1016/S0141-8130(03)00047-3
Barclay, C. J., Widen, C. and Mellors, L. J. (2003). Initial mechanical efficiency of isolated cardiac muscle. Journal of Experimental Biology, 206 (16), 2725-2732. doi: 10.1242/jeb.00480
Barclay, C. J. (2002). Back to the future: cross-bridge working stroke in muscle fibres measured using force steps. The Journal of Physiology, 545 (1), 1-1. doi: 10.1113/jphysiol.2002.032193
Curtin, N. A., Clapham, J. C. and Barclay, C. J. (2002). Excess recovery heat production by isolated muscles from mice overexpressing uncoupling protein-3. Journal of Physiology-London, 542 (1), 231-235. doi: 10.1113/jphysiol.2002.021964
Mellors, LJ and Barclay, CJ (2001). The energetics of rat papillary muscles undergoing realistic strain patterns. Journal of Experimental Biology, 204 (21), 3765-3777.
Mellors, LJ, Gibbs, CL and Barclay, CJ (2001). Comparison of the efficiency of rat papillary muscles during afterloaded isotonic contractions and contractions with sinusoidal length changes. Journal of Experimental Biology, 204 (10), 1765-1774.
Baxi, J, Barclay, CJ and Gibbs, CL (2000). Energetics of rat papillary muscle during contractions with sinusoidal length changes. American Journal of Physiology-Heart and Circulatory Physiology, 278 (5), H1545-H1554.
Barclay, CJ (1999). A weakly coupled version of the Huxley crossbridge model can simulate energetics of amphibian and mammalian skeletal muscle. Journal of Muscle Research and Cell Motility, 20 (2), 163-176. doi: 10.1023/A:1005464231331
West, JM, Barclay, CJ, Luff, AR and Walker, DW (1999). Developmental changes in the activation properties and ultrastructure of fast- and slow-twitch muscles from fetal sheep. Journal of Muscle Research and Cell Motility, 20 (3), 249-264. doi: 10.1023/A:1005433809414
Barclay, CJ (1998). Estimation of cross-bridge stiffness from maximum thermodynamic efficiency. Journal of Muscle Research and Cell Motility, 19 (8), 855-864. doi: 10.1023/A:1005409708838
Gibbs, CL and Barclay, CJ (1998). Efficiency of skeletal and cardiac muscle. Mechanisms of Work Production and Work Absorption in Muscle, 453, 527-536.
Constable, JK, Barclay, CJ and Gibbs, CL (1997). Energetics of lengthening in mouse and toad skeletal muscles. Journal of Physiology-London, 505 (1), 205-215. doi: 10.1111/j.1469-7793.1997.205bc.x
Barclay, CJ (1997). Initial mechanical efficiency in cyclic contractions of mouse skeletal muscle. Journal of Applied Biomechanics, 13 (4), 418-422. doi: 10.1123/jab.13.4.418
Barclay, CJ (1996). Mechanical efficiency and fatigue of fast and slow muscles of the mouse. Journal of Physiology-London, 497 (3), 781-794. doi: 10.1113/jphysiol.1996.sp021809
Barclay, CJ, Arnold, PD and Gibbs, CL (1995). Fatigue and heat production in repeated contractions of mouse skeletal muscle.. Journal of Physiology-London, 488 (3), 741-752. doi: 10.1113/jphysiol.1995.sp021005
Gibbs, CL and Barclay, CJ (1995). Cardiac efficiency. Cardiovascular Research, 30 (5), 627-634. doi: 10.1016/S0008-6363(95)00161-1
Barclay, C. J. (1994). Efficiency of fast- and slow-twitch muscles of the mouse performing cyclic contractions. Journal of Experimental Biology, 193, 65-78.
Barclay, C. J., Constable, J. K. and Gibbs, C. L. (1993). Energetics of fast- and slow-twitch muscles of the mouse. The Journal of Physiology, 472 (1), 61-80. doi: 10.1113/jphysiol.1993.sp019937
Barclay, CJ, Curtin, NA and Woledge, RC (1993). Changes in crossbridge and non‐crossbridge energetics during moderate fatigue of frog muscle fibres.. Journal of Physiology-London, 468 (1), 543-556. doi: 10.1113/jphysiol.1993.sp019787
Barclay, CJ (1992). Effect of Fatigue On Rate of Isometric Force Development in Mouse Fast-Switch and Slow-Twitch Muscles. American Journal of Physiology, 263 (5), C1065-C1072.
Barclay, CJ and Loiselle, DS (1992). Dependence of Muscle Fatigue On Stimulation Protocol - Effect of Hypocaloric Diet. Journal of Applied Physiology, 72 (6), 2278-2284.
Conference Papers
Barclay, Christopher J. and Launikonis, Bradley S. (2019). Determination of heat production in human skeletal muscle from measurements of basal Ca2+ movements. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD, United States, 2-6 March 2019. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2018.11.2805
Barclay, CJ (1999). Efficiency of energy conversion by muscles and its relation to efficiency during locomotion. 10th International Conference on the Biochemistry of Exercise - Membranes, Muscle and Exercise, Sydney Australia, Jul 15-19, 1997. HUMAN KINETICS PUBL.