Dr Debottam Sinha
Honorary Research Fellow
School of Biomedical Sciences
Researcher biography
I am an early career postdoctoral researcher in Prof. Ian Frazer's laboratory. I am a self-motivated young scientist with a research focus on cell and cancer biology, genomic instability, tumour immunology, and cellular therapies. I pursued my doctoral studies under the guidance of Prof. Kum Kum Khanna in QIMR Berghofer and conferred in April 2018, from Griffith University. Prior to my PhD, I acquired a Master of Science degree in Biotechnology, awarded in August 2013 from VIT University, India. After my PhD, I perused my first postdoctoral research experience under the supervision of Prof. Rajiv Khanna at QIMR Berghofer Medical Research Institute. Throughout my PhD studies, my research was focused on the development of novelcombinatorial therapeutic strategies against aggressive solid cancers . I have a strong interest in understanding the relationship between cancer signalling pathways and tumour microenvironment in aggressive malignancies.
Journal Articles
Bromfield, Jacoba I., Zaugg, Julian, Straw, Rodney C., Cathie, Julia, Krueger, Annika, Sinha, Debottam, Chandra, Janin, Hugenholtz, Philip and Frazer, Ian H. (2024). Characterization of the skin microbiome in normal and cutaneous squamous cell carcinoma affected cats and dogs. mSphere, e0055523. doi: 10.1128/msphere.00555-23
Wright, Quentin G, Sinha, Debottam, Wells, James W, Frazer, Ian H, Gonzalez Cruz, Jazmina L and Leggatt, Graham Robert (2024). Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity. Journal for ImmunoTherapy of Cancer, 12 (1) e007960, e007960. doi: 10.1136/jitc-2023-007960
Das, Soumik, Babu, Achsha, Medha, Tamma, Ramanathan, Gnanasambandan, Mukherjee, Anirban Goutam, Wanjari, Uddesh Ramesh, Murali, Reshma, Kannampuzha, Sandra, Gopalakrishnan, Abilash Valsala, Renu, Kaviyarasi, Sinha, Debottam and George Priya Doss, C. (2023). Molecular mechanisms augmenting resistance to current therapies in clinics among cervical cancer patients. Medical Oncology, 40 (5) 149, 149. doi: 10.1007/s12032-023-01997-9
Sinha, Debottam, Moseley, Philip, Lu, Xuehan, Wright, Quentin, Gabrielli, Brian, Frazer, Ian H. and Cruz, Jazmina L. G. (2022). Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockade. Cancers, 14 (24) 6150, 1-26. doi: 10.3390/cancers14246150
Rashidieh, Behnam, Shohayeb, Belal, Bain, Amanda Louise, Fortuna, Patrick R. J., Sinha, Debottam, Burgess, Andrew, Mills, Richard, Adams, Rachael C., Lopez, J. Alejandro, Blumbergs, Peter, Finnie, John, Kalimutho, Murugan, Piper, Michael, Hudson, James Edward, Ng, Dominic C. H. and Khanna, Kum Kum (2021). Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis. PLoS Genetics, 17 (10) e1009334, e1009334. doi: 10.1371/journal.pgen.1009334
Sinha, Debottam and Khanna, Rajiv (2021). EBV and myeloid-derived suppressor cells. Blood, 137 (2), 148-150. doi: 10.1182/blood.2020008640
Sinha, Debottam, Srihari, Sriganesh, Beckett, Kirrliee, Le Texier, Laetitia, Solomon, Matthew, Panikkar, Archana, Ambalathingal, George R., Lekieffre, Lea, Crooks, Pauline, Rehan, Sweera, Neller, Michelle A., Smith, Corey and Khanna, Rajiv (2021). 'Off-the-shelf' allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies. Journal for Immunotherapy of Cancer, 9 (2) e001608, e001608. doi: 10.1136/jitc-2020-001608
Altaf, Mohammed, Lineburg, Katie E., Crooks, Pauline, Rehan, Sweera, Matthews, Katherine K., Neller, Michelle A, Ambalathingal, George R., Sinha, Debottam, Grant, Michelle, Hopkins, Peter M. A., Chambers, Daniel, Khanna, Rajiv and Smith, Corey (2020). Pre-transplant cytomegalovirus-specific cellular immunity and risk of viral reactivation following lung transplantation: a prospective cohort study. The Journal of infectious diseases, 224 (2), 312-317. doi: 10.1093/infdis/jiaa750
Sinha, Debottam, Nag, Purba, Nanayakkara, Devathri, Duijf, Pascal H. G., Burgess, Andrew, Raninga, Prahlad, Smits, Veronique A. J., Bain, Amanda L., Subramanian, Goutham, Wall, Meaghan, Finnie, John. W., Kalimutho, Murugan and Khanna, Kum Kum (2020). Cep55 overexpression promotes genomic instability and tumorigenesis in mice. Communications Biology, 3 (1) 593, 1-16. doi: 10.1038/s42003-020-01304-6
Sinha, Debottam, Smith, Corey and Khanna, Rajiv (2020). Joining Forces: Improving Clinical Response to Cellular Immunotherapies with Small-Molecule Inhibitors. Trends in Molecular Medicine, 27 (1), 75-90. doi: 10.1016/j.molmed.2020.09.005
Raninga, Prahlad, Lee, Andy, Sinha, Debottam, Dong, Lan-feng, Datta, Keshava, Lu, Xue, Kalita-de Croft, Priyakshi, Dutt, Mriga, Hill, Michelle M., Pouliot, Normand M., Gowda, Harsha, Kalimutho, Murugan, Neuzil, Jiri and Khanna, Kum Kum (2020). Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition. Theranostics, 10 (12), 5259-5275. doi: 10.7150/thno.42705
Raninga, Prahlad V., Lee, Andy C., Sinha, Debottam, Shih, Yu-Yin, Mittal, Deepak, Makhale, Ashwini, Bain, Amanda L., Nanayakarra, Devathri, Tonissen, Kathryn F., Kalimutho, Murugan and Khanna, Kum Kum (2020). Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer. International Journal of Cancer, 146 (1), 123-136. doi: 10.1002/ijc.32410
Dasari, Vijayendra, Sinha, Debottam, Neller, Michelle A, Smith, Corey and Khanna, Rajiv (2019). Prophylactic and therapeutic strategies for Epstein-Barr virus-associated diseases: emerging strategies for clinical development. Expert Review of Vaccines, 18 (5), 457-474. doi: 10.1080/14760584.2019.1605906
Kalimutho, Murugan, Sinha, Debottam, Mittal, Deepak, Srihari, Sriganesh, Nanayakkara, Devathri, Shafique, Shagufta, Raninga, Prahlad, Nag, Purba, Parsons, Kate and Khanna, Kum Kum (2019). Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer. Journal of Experimental and Clinical Cancer Research, 38 (1) 85, 1-18. doi: 10.1186/s13046-019-1075-5
Sinha, Debottam, Duijf, Pascal H.G. and Khanna, Kum Kum (2019). Mitotic slippage: an old tale with a new twist. Cell Cycle, 18 (1), 7-15. doi: 10.1080/15384101.2018.1559557
Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018). CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 (9) e8566. doi: 10.15252/emmm.201708566
Sinha, Debottam, Kalimutho, Murugan, Bowles, Josephine, Chan, Ai-Leen, Merriner, D. Jo, Bain, Amanda L., Simmons, Jacinta L., Freire, Raimundo, Lopez, J Alejandro, Hobbs, Robin M., O'Bryan, Moira K. and Khanna, Kum Kum (2018). Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling. The FASEB Journal, 32 (9), 4984-4999. doi: 10.1096/fj.201701096RR
Kalimutho, Murugan, Bain, Amanda L., Mukherjee, Bipasha, Nag, Purba, Nanayakkara, Devathri M., Harten, Sarah K., Harris, Janelle L., Subramanian, Goutham N., Sinha, Debottam, Shirasawa, Senji, Srihari, Sriganesh, Burma, Sandeep and Khanna, Kum Kum (2017). Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. Molecular Oncology, 11 (5), 470-490. doi: 10.1002/1878-0261.12040
Mittal, Deepak, Sinha, Debottam, Barkauskas, Deborah, Young, Arabella, Kalimutho, Murugan, Stannard, Kimberley, Caramia, Franco, Haibe-Kains, Benjamin, Stagg, John, Khanna, Kum Kum, Loi, Sherene and Smyth, Mark J. (2016). Adenosine 2B receptor expression on cancer cells promotes metastasis. Cancer Research, 76 (15), 4372-4382. doi: 10.1158/0008-5472.CAN-16-0544
Jeffery, J., Sinha, D., Srihari, S., Kalimutho, M. and Khanna, K. K. (2015). Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis. Oncogene, 35 (6), 683-690. doi: 10.1038/onc.2015.128
Doss, C. George Priya, Chakrabarty, Chiranjib, Debajyoti, C. and Debottam, S. (2014). Understanding Sequence Similarity and Framework Analysis Between Centromere Proteins Using Computational Biology. Cell Biochemistry and Biophysics, 70 (2), 897-906. doi: 10.1007/s12013-014-9997-1
Doss, C. George Priya, Debajyoti, C. and Debottam, S. (2013). Disruption of Mitochondrial Complexes in Cancer Stem Cells Through Nano-based Drug Delivery: A Promising Mitochondrial Medicine. Cell Biochemistry and Biophysics, 67 (3), 1075-1079. doi: 10.1007/s12013-013-9607-7
Doss, C. George Priya, Debottam, S. and Debajyoti, C. (2013). Glutathione-responsive nano-transporter-mediated siRNA delivery: silencing the mRNA expression of Ras. Protoplasma, 250 (3), 787-792. doi: 10.1007/s00709-012-0451-1
Doss, C. George Priya, Debajyoti, C. and Debottam, S. (2012). The impact of gold nanoparticles on hTERT gene expression leading to termination of malignant tumor. Gene, 493 (1), 140-141. doi: 10.1016/j.gene.2011.11.020
Conference Papers
Wright, Q., Sinha, D., Gonzalez-Cruz, J., Frazer, I. and Leggatt, G. (2022). Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivo. ESMO Immuno-Oncology Congress 2022, Geneva, Switzerland, 7-9 December 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.iotech.2022.100289
Sinha, D. and Khanna, R. (2021). Preclinical assessment of off-the-shelf allogeneic T-cell therapy for the treatment of multiple Epstein-Barr virus-associated malignancies. ISCT2021, Virtual, 26-28 May 2021. Oxford, United Kingdom: Elsevier. doi: 10.1016/s1465324921004151
Raninga, P., Lee, A., Sinha, D., Shin, Y-Y., Mittal, D., Kalimutho, M. and Khanna, K. K. (2019). Synergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancer. 44th Congress of the European-Society-for-Medical-Oncology (ESMO), Barcelona, Spain, 27 September - 1 October 2019. Oxford, United Kingdom: Oxford University Press.
Sinha, D. (2019). Strategic inhibition of CEP55 in aggressive breast cancer leads to mitotic catastrophe. 44th Congress of the European-Society-for-Medical-Oncology (ESMO), Barcelona, Spain, 27 September - 1 October 2019. Oxford, United Kingdom: Oxford University Press.
Sinha, D., Kalimutho, M., Bain, A.L. and Khanna, K.K. (2018). CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo. 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, Netherlands, 30 June – 3 July 2018. London, United Kingdom: Elsevier. doi: 10.1136/esmoopen-2018-eacr25.730
Raninga, P., Kalimutho, M., Sinha, D., Bain, A., Tonissen, K. and Khanna, K. K. (2017). Targeting thioredoxin reductase 1 in novel combination therapies in p53 mutant triple negative breast cancer. 42nd European Society for Medical Oncology Congress (ESMO), Madrid, Spain, 8-12 September 2017. Oxford, United Kingdom: Oxford University Press.
Sinha, D., Kalimutho, M., Lopez, A. J. and Khanna, K. K. (2017). Synergistic inhibition of CEP55 induces mitotic catastrophe and specifically targets aggressive breast cancer. 42nd European-Society-for-Medical-Oncology Congress (ESMO), Madrid, Spain, 8-12 September 2017. Oxford, United Kingdom: OXFORD UNIV.
Sinha, Debottam, Kalimutho, Murugan, Lopez, J. Alejandro and Khanna, Kum Kum (2017). Dual inhibition of MEK1/2 and PLK1 specifically targets aggressive breast cancer cell population with CEP55 elevated expression. Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC , United States, 1-5 April 2017. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2017-1144
Sinha, Debottam, Anwar, K., Kumari, K., Jaishwal, S., Madeshwaran, S., Keshari, S., Babu, D. Rajan, Vidya, R. and Nambiraj, Arunai N. (2012). Studies on the Dielectric properties of Natural Urinary Stones. International Conference on Recent Trends in Advanced Materials (ICRAM 2012), Vellore, India, 20-22 February 2012. Baech, Switzerland: Scientific.Net. doi: 10.4028/www.scientific.net/amr.584.484