Dr Neville Butcher
Senior Research Fellow
School of Biomedical Sciences
Neville is part of the Rash group which studiesĀ Ion channel pharmacology.
Book Chapters
Butcher, Neville J., Li, Pengcheng, Wang, Lili and Minchin, Rodney F. (2018). Human Arylamine N-Acetyltransferase Type 1. Arylamine N-acetyltransferases in Health and Disease: From Pharmacogenetics to Drug Discovery and Diagnostics. (pp. 91-107) edited by Nicola Laurieri and Edith Sim. Singapore: World Scientific Publishing. doi: 10.1142/9789813232013_0004
Butcher, Neville J. and Minchin, Rodney F. (2008). Arylamine N-Acetyltransferases. Encyclopedia of cancer. (pp. 255-257) edited by Manfred Schwab. Berlin, Germany: Springer Verlag. doi: 10.1007/978-3-540-47648-1_408
Butcher, N. J. and Minchin, R. F. (2005). Arylamine N-Acetyltransferase Gene Polymorphism. Encyclopedia of Medical Genomics and Proteomics. (pp. 79-83) edited by Jurgen Fuchs and Maurizio Podda. New York: Marcel Dekker.
Journal Articles
Kaminskas, Lisa M., Butcher, Neville J., Subasic, Christopher N., Kothapalli, Ashok, Haque, Shadabul, Grace, James L., Morsdorf, Alexander, Blanchfield, Joanne T., Whittaker, Andrew K., Quinn, John F. and Whittaker, Michael R. (2024). Lipidated brush-PEG polymers as low molecular weight pulmonary drug delivery platforms. Expert Opinion On Drug Delivery, 21 (1), 151-167. doi: 10.1080/17425247.2024.2305116
Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2023). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal. doi: 10.1093/eurheartj/ehad793
Choudhury, Chandra, Gill, Melinder K., McAleese, Courtney E., Butcher, Neville J., Ngo, Shyuan T., Steyn, Frederik J. and Minchin, Rodney F. (2023). The arylamine N-acetyltransferases as therapeutic targets in metabolic diseases associated with mitochondrial dysfunction. Pharmacological Reviews, 76 (2), 300-320. doi: 10.1124/pharmrev.123.000835
Subasic, Christopher N., Butcher, Neville J., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2023). Dose-dependent effect of phenothiazines as dynamin II inhibitors on the uptake of PEGylated liposomes by endocytic cells and in vivo pharmacokinetics of PEGylated liposomal doxorubicin in rats. Molecular Pharmaceutics, 20 (9), 4468-4477. doi: 10.1021/acs.molpharmaceut.3c00102
Ibrahim, Jibriil P., Butcher, Neville J., Kothapalli, Ashok, Subasic, Christopher N., Blanchfield, Joanne T., Whittaker, Andrew K., Whittaker, Michael R and Kaminskas, Lisa M. (2023). Utilization of endogenous albumin trafficking pathways in the lungs has potential to modestly increase the lung interstitial access and absorption of drug delivery systems after inhaled administration. Expert Opinion on Drug Delivery, 20 (8), 1145-1155. doi: 10.1080/17425247.2023.2244881
Choudhury, Chandra, McAleese, Courtney E., Butcher, Neville J. and Minchin, Rodney F. (2023). Contrasting effects of temperature on human arylamine N-acetyltransferase and acetyl coenzyme A hydrolase activities. Biochemistry, 62 (14), 2093-2097. doi: 10.1021/acs.biochem.3c00113
Subasic, Christopher N., Butcher, Neville J., Minchin, Rodney F. and Kaminskas, Lisa M. (2023). Dose-dependent production of anti-PEG IgM after intramuscular PEGylated-hydrogenated soy phosphatidylcholine liposomes, but not lipid nanoparticle formulations of DNA, correlates with the plasma clearance of PEGylated liposomal doxorubicin in rats. Molecular Pharmaceutics, 20 (7), 3494-3504. doi: 10.1021/acs.molpharmaceut.3c00104
McAleese, Courtney E., Butcher, Neville J. and Minchin, Rodney F. (2022). Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis. Breast Cancer Research and Treatment, 195 (3), 223-236. doi: 10.1007/s10549-022-06668-3
Choudhury, Chandra, Butcher, Neville J. and Minchin, Rodney F. (2022). Polymorphism in the human arylamine N-acetyltransferase 1 gene 3ā²-untranslated region determines polyadenylation signal usage. Biochemical Pharmacology, 200 115020, 115020. doi: 10.1016/j.bcp.2022.115020
Subasic, Christopher N., Ardana, Aditya, Chan, Linda J., Huang, Fei, Scoble, Judith A., Butcher, Neville J., Meagher, Laurence, Chiefari, John, Kaminskas, Lisa M. and Williams, Charlotte C. (2021). Poly(HPMA-co-NIPAM) copolymer as an alternative to polyethylene glycol-based pharmacokinetic modulation of therapeutic proteins. International Journal of Pharmaceutics, 608 121075, 121075. doi: 10.1016/j.ijpharm.2021.121075
McAleese, Courtney E., Choudhury, Chandra, Butcher, Neville J. and Minchin, Rodney F. (2021). Hypoxia-mediated drug resistance in breast cancers. Cancer Letters, 502, 189-199. doi: 10.1016/j.canlet.2020.11.045
Wang, Lili, Butcher, Neville J, Minchin, Rodney F and Kaminskas, Lisa M (2021). Monocytes do not contribute to sex differences seen in the pharmacokinetics of pegylated liposomal doxorubicin. Journal of Pharmaceutical Sciences, 110 (8), 3099-3101. doi: 10.1016/j.xphs.2021.05.009
Butcher, Neville J., Burow, Rachel and Minchin, Rodney F. (2020). Modulation of human arylamine N-acetyltransferase 1 activity by lysine acetylation: role of p300/CREB-binding protein and sirtuins 1 and 2. Molecular Pharmacology, 98 (2), 88-95. doi: 10.1124/mol.119.119008
Idris, Misgana, Mitchell, Deanne J., Gordon, Richard, Sidharthan, Neelima P., Butcher, Neville J. and Minchin, Rodney F. (2020). Interaction of the brain-selective sulfotransferase SULT4A1 with other cytosolic sulfotransferases: effects on protein expression and function. Drug Metabolism and Disposition, 48 (5), 337-344. doi: 10.1124/dmd.119.089714
Li, Pengcheng, Butcher, Neville J. and Minchin, Rodney F. (2020). Effect arylamine N-acetyltransferase 1 on morphology, adhesion, migration, and invasion of MDA-MB-231 cells: role of matrix metalloproteinases and integrin Ī±V. Cell Adhesion and Migration, 14 (1), 1-11. doi: 10.1080/19336918.2019.1710015
Li, Pengcheng, Butcher, Neville J. and Minchin, Rod (2019). Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-Ī±. Molecular Pharmacology, 96 (5), 573-579. doi: 10.1124/mol.119.117432
Wang, Lili, Minchin, Rodney F., Essebier, Patricia J. and Butcher, Neville J. (2019). Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex. International Journal of Biochemistry and Cell Biology, 110, 84-90. doi: 10.1016/j.biocel.2019.03.002
Kaminskas, Lisa M., Williams, Charlotte C., Leong, Nathania J., Chan, Linda J., Butcher, Neville J., Feeney, Orlagh M., Porter, Christopher J.H., Tyssen, David, Tachedjian, Gilda and Ascher, David B. (2019). A 30āÆkDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats. European Journal of Pharmaceutics and Biopharmaceutics, 137, 218-226. doi: 10.1016/j.ejpb.2019.03.008
Idris, Misgana, Butcher, Neville J and Minchin, Rodney F (2019). The MBNL/CELF splicing factors regulate cytosolic sulfotransferase 4A1 protein expression during cell differentiation. Drug Metabolism and Disposition, 47 (3), 314-319. doi: 10.1124/dmd.118.085290
Minchin, Rodney F., Rosengren, K. Johan, Burow, Rachel and Butcher, Neville J. (2018). Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate. Biochemical Pharmacology, 158, 153-160. doi: 10.1016/j.bcp.2018.10.013
Minchin, Rodney F. and Butcher, Neville J. (2018). Trimodal distribution of arylamine N-acetyltransferase 1 mRNA in breast cancer tumors: association with overall survival and drug resistance. BMC Genomics, 19 (1) 513, 513. doi: 10.1186/s12864-018-4894-4
Wang, LiLi, Minchin, Rodney F and Butcher, Neville J (2018). Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability. PLoS One, 13 (3) e0193560, e0193560. doi: 10.1371/journal.pone.0193560
Butcher, N. J., Horne, M. K., Mellick, G. D., Fowler, C. J., Masters, C. L. and Minchin, R. F. (2017). Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease. Pharmacogenomics Journal, 18 (2), 209-214. doi: 10.1038/tpj.2017.4
Witham, Katey L., Minchin, Rodney F. and Butcher, Neville J. (2017). Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway. Biochemical Pharmacology, 125, 93-100. doi: 10.1016/j.bcp.2016.11.015
Butcher, Neville J., Mortimer, Gysell M. and Minchin, Rodney F. (2016). Drug delivery: unravelling the stealth effect. Nature Nanotechnology, 11 (4), 310-311. doi: 10.1038/nnano.2016.6
Minchin, Rodney F and Butcher, Neville J (2015). The role of lysine100 in the binding of acetylcoenzyme A to human arylamine N-acetyltransferase 1: Implications for other acetyltransferases. Biochemical Pharmacology, 94 (3), 195-202. doi: 10.1016/j.bcp.2015.01.015
Tiang, Jacky M., Butcher, Neville J. and Minchin, Rodney F. (2015). Effects of human arylamine N-acetyltransferase I knockdown in triple-negative breast cancer cell lines. Cancer Medicine, 4 (4), 565-574. doi: 10.1002/cam4.415
Sidharthan, Neelima P., Butcher, Neville J., Mitchell, Deanne J. and Minchin, Rodney F. (2014). Expression of the orphan cytosolic sulfotransferase SULT4A1 and its major splice variant in human tissues and cells: dimerization, degradation and polyubiquitination. PLoS One, 9 (7) e101520, e101520.1-e101520.8. doi: 10.1371/journal.pone.0101520
Stephenson, Rachel, Varamini, Pegah, Butcher, Neville, Minchin, Rodney and Toth, Istvan (2014). Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro. Nanomedicine: Nanotechnology, Biology and Medicine, 10 (8), 1799-1808. doi: 10.1016/j.nano.2014.06.015
Mortimer, Gysell M., Butcher, Neville J., Musumeci, Anthony W., Deng, Zhou J., Martin, Darren J. and Minchin, Rodney F. (2014). Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials. ACS Nano, 8 (4), 3357-3366. doi: 10.1021/nn405830g
Deng, Zhou J., Butcher, Neville J., Mortimer, Gysell M., Jia, Zhongfan, Monteiro, Michael J., Martin, Darren J. and Minchin, Rodney F. (2014). Interaction of human arylamine n-acetyltransferase 1 with different nanomaterials. Drug Metabolism and Disposition, 42 (3), 377-383. doi: 10.1124/dmd.113.055988
Sidharthan, Neelima P., Minchin, Rodney F. and Butcher, Neville J. (2013). Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: Role of D1 receptor-n-methyl-d-aspartate receptor coupling. Journal of Biological Chemistry, 288 (48), 34364-34374. doi: 10.1074/jbc.M113.493239
Witham, Katey L., Butcher, Neville J., Sugamori, Kim S., Brenneman, Debbie, Grant, Denis M. and Minchin, Rodney F. (2013). 5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. PLoS One, 8 (10) e77923, e77923.1-e77923.7. doi: 10.1371/journal.pone.0077923
Butcher, Neville J. and Minchin, Rodney F. (2012). Arylamine N-acetyltransferase 1: A novel drug target in cancer development. Pharmacological Reviews, 64 (1), 147-165. doi: 10.1124/pr.110.004275
Tiang, JM, Butcher, NJ, Cullinane, C, Humbert, PO and Minchin, RF (2011). RNAi-mediated knock-down of Arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition. PLoS One, 6 (2) e17031, 1-10. doi: 10.1371/journal.pone.0017031
Mitchell, Deanne J., Butcher, Neville J. and Minchin, Rodney F. (2011). Phosphorylation/dephosphorylation of human SULT4A1: Role of Erk1 and PP2A. Biochimica et Biophysica Acta - Molecular Cell Research, 1813 (1), 231-237. doi: 10.1016/j.bbamcr.2010.09.011
Paterson, S, Sin, KL, Tiang, JM, Minchin, RF and Butcher, NJ (2011). Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells. Drug Metabolism and Disposition, 39 (1), 77-82. doi: 10.1124/dmd.110.036202
Butcher, Neville J., Mitchell, Deanne J., Burow, Rachel and Minchin, Rodney F. (2010). Regulation of Mouse Brain-Selective Sulfotransferase Sult4a1 by cAMP Response Element-Binding Protein and Activating Transcription Factor-2. Molecular Pharmacology, 78 (3), 503-510. doi: 10.1124/mol.110.063404
Butcher, Neville J. and Minchin, Rodney F. (2010). Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1. Carcinogenesis, 31 (5), 820-826. doi: 10.1093/carcin/bgq042
Tiang, Jacky M., Butcher, Neville J. and Minchin, Rodney F. (2010). Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells. Biochemical and Biophysical Research Communications, 393 (1), 95-100. doi: 10.1016/j.bbrc.2010.01.087
Butcher, Neville J., Tiang, Jacky and Minchin, Rodney F. (2008). Regulation of arylamine N-acetyltransferases. Current Drug Metabolism, 9 (6), 498-504. doi: 10.2174/138920008784892128
Butcher, Neville J., Broadhurst, Gysell M. and Minchin, Rodney F. (2007). Polyamine-dependent regulation of spermidine-spermine N-1-acetyltransferase mRNA translation. Journal of Biological Chemistry, 282 (39), 28530-28539. doi: 10.1074/jbc.M701265200
Minchin, RF, Hanna, PE, Dupret, JM, Wagner, CR, Rodrigues-Lima, F and Butcher, NJ (2007). Arylamine N-acetyltransferase I. International Journal of Biochemistry & Cell Biology, 39 (11), 1999-2005. doi: 10.1016/j.biocel.2006.12.006
Butcher, Neville J., Tetlow, Natasha L., Cheung, Catherine, Broadhurst, Gysell M. and Minchin, Rodney F. (2007). Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Research, 67 (1), 85-92. doi: 10.1158/0008-5472.CAN-06-2635
Butcher, N. J., Arulpragasam, A., Goh, H. L., Davey, Tamara and Minchin, Rodney F. (2005). Genomic organization of human arylamine N-acetyltransferase Type I reveals alternative promoters that generate different 5'-UTR splice variants with altered translational activities. Biochemical Journal, 387 (1), 119-127. doi: 10.1042/BJ20040903
Butcher, Neville J., Arulpragasam, Ajanthy and Minchin, Rodney F. (2004). Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine - A mechanism for the slow acetylator phenotype and substrate-dependent down-regulation. Journal of Biological Chemistry, 279 (21), 22131-22137. doi: 10.1074/jbc.M312858200
Butcher, NJ, Arulpragasam, A, Pope, C and Minchin, RF (2003). Identification of a minimal promoter sequence for the human N-acetyltransferase Type I gene that binds AP-1 (activator protein 1) and YY-1 (Yin and Yang 1). Biochemical Journal, 376 (2), 441-448. doi: 10.1042/BJ20030650
Butcher, N. J., Boukouvala, S., Sim, E. and Minchin, R. F. (2002). Pharmacogenetics of the arylamine N-acetyltransferases. Pharmacogenomics Journal, 2 (1), 30-42. doi: 10.1038/sj.tpj.6500053
Butcher, NJ, Ilett, KF and Minchin, RF (2000). Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells. Molecular Pharmacology, 57 (3), 468-473. doi: 10.1124/mol.57.3.468
Butcher, NJ, Ilett, KF and Minchin, RF (2000). Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid. Biochemical Pharmacology, 60 (12), 1829-1836. doi: 10.1016/S0006-2952(00)00501-3
Butcher, NJ, Ilett, KF and Minchin, RF (1998). Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by (CT)-T-190 and G(560)A mutations. Pharmacogenetics, 8 (1), 67-72. doi: 10.1097/00008571-199802000-00009
Butcher, N.J., Minchin, R.F., Kadlubar, F.F. and llett , K.F. (1996). Uptake of the food-derived heterocyclic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its N-hydroxy metabolite into rat pancreatic acini and hepatocytes in vitro. Carcinogenesis, 17 (4), 889-992. doi: 10.1093/carcin/17.4.889
Conference Papers
Li, P., Minchin, R. F. and Butcher, N. (2019). Regulation of MMP9 expression by human arylamine N-acetyltransferase (NAT1) via Hif-1a. ESMO Breast Cancer, Berlin, Germany, 2-4 May 2019 . Amsterdam, Netherlands: Elsevier.
Minchin, Rodney F. and Butcher, Neville J. (2014). Targeting the Arylamine N-Acetyltransferases in Cancer. 10th International Meeting of the International Society for the Study of Xenobiotics (ISSX), Toronto, Canada, 29 September - 03 October 2013. New York, United States: Informa Healthcare.
Boukouvala, S., Westwood, I. M., Butcher, N. J. and Fakis, G. U. (2008). Current trends in N-acetyltransferase research arising from the 2007 International NAT Workshop. The United Kingdom: Future Medicine Limited. doi: 10.2217/14622416.9.6.765