Dr Sebastian Furness
Amplify Fellow
School of Biomedical Sciences
Researcher biography
Sebastian is an expert on molecular pharmacology of G protein-coupled receptors (GPCRs - the largest class of cell surface recpetors and major drug targets). His lab has a particular interest in those involved in communication between the gastrointestinal tract and brain (the so-called gut-brain axis). Current foccusses include ghrelin, melanocortin 4, dopamine D2, and cholecystokinin receptors and the lab has also worked on the calcitonin, glucagon-like peptide 1 and other receptors. His lab is interested in answering complelling biological questions relating to physiology and pathophysiology of the gut-brain axis all the way down to the level of the receptor.
Sebastian is from Adelaide and received his BSc(Hons) and PhD. from the University of Adelaide, where he worked on the Aryl Hydrocarbon receptor in the lab of Murray Whitelaw. He then did postdoctoral research on haematopoitic stem cell differentiation in Kelly McNagny's lab at the Biomedical Research Centre at the University of British Columbia before joining Patrick Sexton to work on G protein-coupled receptors at Monash University .
Sebastian is now an ARC Future Fellow with his own research program in the School of Biomedical Sciences at the University of Queensland. He remains an adjunct member of MIPS DDB as well as CCeMMP.
Sebastian has honours and PhD positions for motivated students who have a strong desire to assume ownership of a project and work independently.
Book Chapters
Ostrovskaya, A., Findlay, D. M., Sexton, P. M. and Furness, S. G. B. (2017). Calcitonin. Reference module in neuroscience and biobehavioral psychology. (pp. - ) Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-809324-5.03223-5
Just, Rasmus, Simms, John, Furness, Sebastian G. B., Christopoulos, Arthur and Sexton, Patrick M. (2009). Understanding amylin receptors. The calcitonin gene-related peptide family. (pp. 41-57) Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-90-481-2909-6_3
Journal Articles
Harikumar, Kaleeckal G., Zhao, Peishen, Cary, Brian P., Xu, Xiaomeng, Desai, Aditya J., Dong, Maoqing, Mobbs, Jesse I., Toufaily, Chirine, Furness, Sebastian G.B., Christopoulos, Arthur, Belousoff, Matthew J., Wootten, Denise, Sexton, Patrick M. and Miller, Laurence J. (2024). Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. PLoS Biology, 22 (7 July) e3002673, e3002673. doi: 10.1371/journal.pbio.3002673
Ham, Seungmin, Mukaida, Saori, Sato, Masaaki, Keov, Peter, Bengtsson, Tore, Furness, Sebastian, Holliday, Nicholas D., Evans, Bronwyn A., Summers, Roger J. and Hutchinson, Dana S. (2024). Role of G protein‐coupled receptor kinases (GRKs ) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research & Perspectives, 12 (1) e1176, e1176. doi: 10.1002/prp2.1176
Bloxham, Conor J., Hulme, Katina D., Fierro, Fabrizio, Fercher, Christian, Pegg, Cassandra L., O'Brien, Shannon L., Foster, Simon R., Short, Kirsty R., Furness, Sebastian G. B., Reichelt, Melissa E., Niv, Masha Y. and Thomas, Walter G. (2024). Cardiac human bitter taste receptors contain naturally occurring variants that alter function. Biochemical Pharmacology, 219 115932, 115932. doi: 10.1016/j.bcp.2023.115932
Ringuet, Mitchell T., Koo, Ada, Furness, Sebastian G. B., McDougall, Stuart J. and Furness, John B. (2023). Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre. The Journal of Physiology, 601 (23), 5195-5211. doi: 10.1113/jp285217
Ringuet, Mitchell Ty, Furness, John Barton and Furness, Sebastian George Barton (2022). G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a. Journal of Neuroendocrinology, 34 (9) e13077, 1-14. doi: 10.1111/jne.13077
Piper, Noah B.C., Whitfield, Emily A., Stewart, Gregory D., Xu, Xiaomeng and Furness, Sebastian G.B. (2022). Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors. Biochemical Pharmacology, 202 115115, 1-21. doi: 10.1016/j.bcp.2022.115115
Harikumar, Kaleeckal G., Coudrat, Thomas, Desai, Aditya J., Dong, Maoqing, Dengler, Daniela G., Furness, Sebastian G. B., Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A., Sexton, Patrick M. and Miller, Laurence J. (2021). Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterol. Frontiers in Endocrinology, 12 789957. doi: 10.3389/fendo.2021.789957
Wookey, Peter, Gupta, Pragya, Bittencourt, Lucas, Cheung, Shane, Hare, David and Furness, Sebastian (2021). Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy. F1000Research, 10 1019, 1-6. doi: 10.12688/f1000research.72845.1
Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J. and Sexton, Patrick M. (2021). Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLOS Biology, 19 (6) e3001295, e3001295. doi: 10.1371/journal.pbio.3001295
Fletcher, Madeleine M., Keov, Peter, Truong, Tin T., Mennen, Grace, Hick, Caroline A., Zhao, Peishen, Furness, Sebastian G.B., Kruse, Thomas, Clausen, Trine R., Wootten, Denise and Sexton, Patrick M. (2021). AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists. Journal of Pharmacology and Experimental Therapeutics, 377 (3), 417-440. doi: 10.1124/jpet.121.000567
Furness, John B., Pustovit, Ruslan V., Syder, Andrew J., Ringuet, Mitchell T., Yoo, Eun Ji, Fanjul, Andrea, Wykosky, Jill, Fothergill, Linda J., Whitfield, Emily A. and Furness, Sebastian G. B. (2021). Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers. Neurogastroenterology and Motility, 33 (5) e14051. doi: 10.1111/nmo.14051
Liu, Mengjie, Whitfield, Emily A., Fothergill, Linda J., Furness, John B., Wade, John D., Furness, Sebastian G.B. and Hossain, Mohammed Akhter (2020). Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin. Biochemical and Biophysical Research Communications, 533 (3), 559-564. doi: 10.1016/j.bbrc.2020.09.028
Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Differential GLP-1R binding and activation by peptide and non-peptide agonists. Molecular Cell, 80 (3), 485-500.e7. doi: 10.1016/j.molcel.2020.09.020
Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M. and Miller, Laurence J. (2020). Structure and dynamics of the active Gs-coupled human secretin receptor. Nature Communications, 11 (1) 4137, 4137. doi: 10.1038/s41467-020-17791-4
Liang, Yi-Lynn, Belousoff, Matthew J., Fletcher, Madeleine M., Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G. B., Miller, Laurence J., Hay, Debbie L., Christopoulos, Arthur, Reynolds, Christopher A., Danev, Radostin, Wootten, Denise and Sexton, Patrick M. (2020). Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins. ACS Pharmacology and Translational Science, 3 (2), 263-284. doi: 10.1021/acsptsci.9b00080
Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577 (7790), 432-436. doi: 10.1038/s41586-019-1902-z
Gupta, Pragya, Furness, Sebastian G. B., Bittencourt, Lucas, Hare, David L. and Wookey, Peter J. (2020). Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma. Therapeutic Advances in Medical Oncology, 12, 175883592097811. doi: 10.1177/1758835920978110
Zhao, Peishen and Furness, Sebastian G.B. (2019). The nature of efficacy at G protein-coupled receptors. Biochemical Pharmacology, 170 113647, 1-13. doi: 10.1016/j.bcp.2019.113647
Nguyen, Huynh T. H., Wood, Rhiannon J., Prawdiuk, Alexa R., Furness, Sebastian G. B., Xiao, Junhua, Murray, Simon S. and Fletcher, Jessica L. (2019). TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum. Frontiers in Molecular Neuroscience, 12 205, 1-12. doi: 10.3389/fnmol.2019.00205
Draper-Joyce, Christopher and Furness, Sebastian George Barton (2019). Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors. ACS Pharmacology and Translational Science, 2 (4), 285-290. doi: 10.1021/acsptsci.9b00054
Pham, Vi, Zhu, Yue, Dal Maso, Emma, Reynolds, Christopher A., Deganutti, Giuseppe, Atanasio, Silvia, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Furness, Sebastian G. B., Wang, Ming-Wei, Wootten, Denise and Sexton, Patrick M. (2019). Deconvoluting the molecular control of binding and signaling at the amylin 3 receptor: RAMP3 alters signal propagation through extracellular loops of the calcitonin receptor. ACS Pharmacology and Translational Science, 2 (3), 183-197. doi: 10.1021/acsptsci.9b00010
Ostrovskaya, Anna, Hick, Caroline, Hutchinson, Dana S., Stringer, Brett W., Wookey, Peter J., Wootten, Denise, Sexton, Patrick M. and Furness, Sebastian G.B. (2019). Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas. BMC Cancer, 19 (1) 157, 157. doi: 10.1186/s12885-019-5369-y
dal Maso, Emma, Glukhova, Alisa, Zhu, Yue, Garcia-Nafria, Javier, Tate, Christopher G., Atanasio, Silvia, Reynolds, Christopher A., Ramírez-Aportela, Erney, Carazo, Jose-Maria, Hick, Caroline A., Furness, Sebastian G. B., Hay, Debbie L., Liang, Yi-Lynn, Miller, Laurence J., Christopoulos, Arthur, Wang, Ming-Wei, Wootten, Denise and Sexton, Patrick M. (2019). The molecular control of calcitonin receptor signaling. ACS Pharmacology and Translational Science, 2 (1), 31-51. doi: 10.1021/acsptsci.8b00056
Furness, S. G. B., Christopoulos, A., Sexton, P. M. and Wootten, D. (2018). Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1. Biochemical Pharmacology, 156, 223-240. doi: 10.1016/j.bcp.2018.08.033
Liang, Yi-Lynn, Zhao, Peishen, Draper-Joyce, Christopher, Baltos, Jo-Anne, Glukhova, Alisa, Truong, Tin T., May, Lauren T., Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M. and Furness, Sebastian G. B. (2018). Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination. ACS Pharmacology and Translational Science, 1 (1), 12-20. doi: 10.1021/acsptsci.8b00017
Draper-Joyce, Christopher J., Khoshouei, Maryam, Thal, David M., Liang, Yi-Lynn, Nguyen, Anh T. N., Furness, Sebastian G. B., Venugopal, Hariprasad, Baltos, Jo-Anne, Plitzko, Jürgen M., Danev, Radostin, Baumeister, Wolfgang, May, Lauren T., Wootten, Denise, Sexton, Patrick M., Glukhova, Alisa and Christopoulos, Arthur (2018). Structure of the adenosine-bound human adenosine A1 receptor–Gi complex. Nature, 558 (7711), 559-563. doi: 10.1038/s41586-018-0236-6
Dal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B. and Wootten, Denise (2018). Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochemical Pharmacology, 150, 214-244. doi: 10.1016/j.bcp.2018.02.005
Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B., Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T., Thal, David M., Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M. and Wootten, Denise (2018). Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex. Nature, 555 (7694), 121-125. doi: 10.1038/nature25773
Dal Maso, Emma, Just, Rasmus, Hick, Caroline, Christopoulos, Arthur, Sexton, Patrick M., Wootten, Denise and Furness, Sebastian G.B. (2018). Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms. Biochemical Pharmacology, 148, 111-129. doi: 10.1016/j.bcp.2017.12.016
Furness, Sebastian G.B. and Sexton, Patrick M. (2017). Coding GPCR-G protein specificity. Cell Research, 27 (10), 1193-1194. doi: 10.1038/cr.2017.92
Gilabert-Oriol, Roger, Furness, Sebastian G. B., Stringer, Brett W., Weng, Alexander, Fuchs, Hendrik, Day, Bryan W., Kourakis, Angela, Boyd, Andrew W., Hare, David L., Thakur, Mayank, Johns, Terrance G. and Wookey, Peter J. (2017). Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma. Cancer Immunology, Immunotherapy, 66 (9), 1217-1228. doi: 10.1007/s00262-017-2013-z
Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M., Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K., Wootten, Denise, Skiniotis, Georgios and Sexton, Patrick M. (2017). Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature, 546 (7656), 118-123. doi: 10.1038/nature22327
Furness, Sebastian G. B., Wootten, Denise and Sexton, Patrick M (2017). What determines the magnitude of cellular response for activation of G protein-coupled receptors?. Cell Cycle, 16 (5), 392-394. doi: 10.1080/15384101.2016.1271634
Furness, Sebastian George Barton, Liang, Yi-Lynn, Nowell, Cameron James, Halls, Michelle Louise, Wookey, Peter John, Dal Maso, Emma, Inoue, Asuka, Christopoulos, Arthur, Wootten, Denise and Sexton, Patrick Michael (2016). Ligand-dependent modulation of G protein conformation alters drug efficacy. Cell, 167 (3), 739-749. doi: 10.1016/j.cell.2016.09.021
Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. Biochemical Pharmacology, 118, 68-87. doi: 10.1016/j.bcp.2016.08.015
Wootten, Denise, Reynolds, Christopher A, Smith, Kevin J, Mobarec, Juan C, Koole, Cassandra, Savage, Emilia E, Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G B, Liu, Mengjie, Thompson, Philip E, Miller, Laurence J, Christopoulos, Arthur and Sexton, Patrick M (2016). The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism. Cell, 165 (7), 1632-1643. doi: 10.1016/j.cell.2016.05.023
Wootten, Denise, Reynolds, Christopher A., Koole, Cassandra, Smith, Kevin J., Mobarec, Juan C., Simms, John, Quon, Tezz, Coudrat, Thomas, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from Class B crystal structures. Molecular Pharmacology, 89 (3), 335-47. doi: 10.1124/mol.115.101246
Furness, S.G.B., Hare, D.L., Kourakis, A., Turnley, A.M. and Wookey, P.J. (2016). A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death. Cell Death Discovery, 2 (1) 16062, 1-9. doi: 10.1038/cddiscovery.2016.62
Cook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P. M., Scammells, P. J., Conigrave, A. D., Christopoulos, A. and Leach, K. (2015). Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1), 185-200. doi: 10.1111/bph.12937
Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser and Henriksen, Kim (2014). Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PLoS One, 9 (3) e92042, e92042. doi: 10.1371/journal.pone.0092042
Pabreja, K., Mohd, M. A., Koole, C., Wootten, D. and Furness, S. G.B. (2014). Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. British Journal of Pharmacology, 171 (5), 1114-1128. doi: 10.1111/bph.12313
Savage, Emilia Elizabeth, Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick Michael and Furness, Sebastian George Barton (2013). A simple method to generate stable cell lines for the analysis of transient protein-protein interactions. BioTechniques, 54 (4), 217-221. doi: 10.2144/000114013
Willard, Francis S., Wootten, Denise, Showalter, Aaron D., Savage, Emilia E., Ficorilli, James, Farb, Thomas B., Bokvist, Krister, Alsina-Fernandez, Jorge, Furness, Sebastian G. B., Christopoulos, Arthur, Sexton, Patrick M. and Sloop, Kyle W. (2012). Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Molecular Pharmacology, 82 (6), 1066-1073. doi: 10.1124/mol.112.080432
Hao, Nan, Lee, Kian Leong, Furness, Sebastian G. B., Bosdotter, Cecilia, Poellinger, Lorenz and Whitelaw, Murray L. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82 (6), 1082-1093. doi: 10.1124/mol.112.078873
Harikumar, Kaleeckal G., Wootten, Denise, Pinon, Delia I., Koole, Cassandra, Ball, Alicja M., Furness, Sebastian G. B., Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J. and Sexton, Patrick M. (2012). Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. Proceedings of the National Academy of Sciences of the United States of America, 109 (45), 18607-18612. doi: 10.1073/pnas.1205227109
Sato, Masaaki, Hutchinson, Dana S., Halls, Michelle L., Furness, Sebastian G. B., Bengtsson, Tore, Evans, Bronwyn A. and Summers, Roger J. (2012). Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor. Journal of Biological Chemistry, 287 (24), 20674-20688. doi: 10.1074/jbc.M111.280651
Wookey, Peter J., Mclean, Catriona A., Hwang, Peter, Furness, Sebastian G.B., Nguyen, Sandy, Kourakis, Angela, Hare, David L. and Rosenfeld, Jeffrey V. (2012). The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. Histopathology, 60 (6), 895-910. doi: 10.1111/j.1365-2559.2011.04146.x
Furness, Sebastian G.B., Wootten, Denise, Christopoulos, Arthur and Sexton, Patrick M. (2012). Consequences of splice variation on Secretin family G protein-coupled receptor function. British Journal of Pharmacology, 166 (1), 98-109. doi: 10.1111/j.1476-5381.2011.01571.x
Whelan, Fiona, Hao, Nan, Furness, Sebastian G. B., Whitelaw, Murray L. and Chapman-Smith, Anne (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77 (6), 1037-1046. doi: 10.1124/mol.109.062927
Furness, Sebastian G.B. and Whelan, Fiona (2009). The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles. Pharmacology and Therapeutics, 124 (3), 336-353. doi: 10.1016/j.pharmthera.2009.09.004
Dave, Keyur A., Whelan, Fiona, Bindloss, Colleen, Furness, Sebastian G. B., Chapman-Smith, Anne, Whitelaw, Murray L. and Gorman, Jeffrey J. (2009). Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Molecular & Cellular Proteomics, 8 (4), 706-719. doi: 10.1074/mcp.M800459-MCP200
Morfis, Maria, Tilakaratne, Nanda, Furness, Sebastian G. B., Christopoulos, George, Werry, Tim D., Christopoulos, Arthur and Sexton, Patrick M. (2008). Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology, 149 (11), 5423-5431. doi: 10.1210/en.2007-1735
Furness, Sebastian G.B., Lees, Michael J. and Whitelaw, Murray L. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581 (19), 3616-3625. doi: 10.1016/j.febslet.2007.04.011
Dave, KA, Hamilton, BR, Wallis, TP, Furness, SGB, Whitelaw, ML and Gorman, JJ (2007). Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268 (2-3), 168-180. doi: 10.1016/j.ijms.2007.06.001
Tan, Poh C., Furness, Sebastian G.B., Merkens, Helen, Lin, Shujun, McCoy, Marcia L., Roskelley, Calvin D., Kast, Jürgen and McNagny, Kelly M. (2006). Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem Cells, 24 (5), 1150-1161. doi: 10.1634/stemcells.2005-0426
Furness, Sebastian George Barton and McNagny, Kelly (2006). Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunologic Research, 34 (1), 13-32. doi: 10.1385/ir:34:1:13
Conference Paper
Koole, Cassandra, Pabreja, Kavita, Savage, Emilia E., Wootten, Denise, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2013). Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochemical Society Meeting, London, United Kingdom: Portland Press. doi: 10.1042/BST20120236