Dr Lachlan Rash
Associate Professor
School of Biomedical Sciences
+61 7 336 52745
Researcher biography
Dr Rash completed his Honours (1996) and PhD (2001) on the pharmacological activity of spider venoms at the Department of Pharmacology, Monash University in the group of Professor Wayne Hodgson. After 18 months as an Assistant Lecturer at Monash Pharmacology, he was awarded an INSERM/NH&MRC Post-doctoral Fellowship to work in the group of Prof. Michel Lazdunski at the Institute of Molecular and Cellular Pharmacology in Antibes, France. It was here that he became involved in discovery and characterisation of venom peptides that act on acid-sensing ion channels, voltage-gated sodium channels and other pain related channels. Upon returning to Australia to the Institute for Molecular Bioscience (The University of Queensland), he established an ASIC research program and was awarded an NH&MRC project grant as CIA to investigate the molecular basis of the interaction of PcTx1 and APETx2 with ASIC1a and ASIC3 respectively. Dr Rash was appointed as senior lecturer in Pharmacology in the School of Biomedical Sciences in early 2016 where he continues his research on identifying novel bioactive peptides from animal venoms, unravelling the molecular basis for their specific channel interactions and their use as research tools and potential therapeutic lead molecules.
Book Chapters
Geraghty, Dominic P. and Rash, Lachlan D. (2017). Preface. Ion Channels DownUnder. (pp. xi-xii) edited by Dominic P. Geraghty and Lachlan D. Rash. Cambridge, MA, United States: Academic Press. doi: 10.1016/S1054-3589(17)30052-2
Rash, Lachlan D. (2017). Acid-sensing ion channel pharmacology, past, present, and future …. Ion Channels DownUnder. (pp. 35-66) edited by Dominic P. Geraghty and Lachlan D. Rash. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.apha.2017.02.001
Fry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D. ... Sunagar, K. (2015). Research methods. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. (pp. 153-214) New York, NY, United States: Oxford University Press.
Smith, Jennifer J., Lau, Carus Ho Yee, Herzig, Volker, Ikonomopoulou, Maria P., Rash, Lachlan D. and King, Glenn F. (2015). Therapeutic applications of spider-venom peptides. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. (pp. 221-244) edited by Glenn F. King. Cambridge, United Kingdom: Royal Society of Chemistry.. doi: 10.1039/9781849737876-00221
Journal Articles
Budusan, Elena, Payne, Colton D., Gonzalez, Tye I., Obergrussberger, Alison, Becker, Nadine, Clark, Richard J., Rosengren, K. Johan, Rash, Lachlan D. and Cristofori-Armstrong, Ben (2024). The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation. Biochemical Pharmacology 116175, 116175. doi: 10.1016/j.bcp.2024.116175
Knezic, Adriana, Budusan, Elena, Saez, Natalie J., Broughton, Brad R. S., Rash, Lachlan D., King, Glenn F., Widdop, Robert E. and McCarthy, Claudia A. (2024). Hi1a Improves Sensorimotor Deficit following Endothelin-1-Induced Stroke in Rats but Does Not Improve Functional Outcomes following Filament-Induced Stroke in Mice. ACS Pharmacology & Translational Science, 7 (4), 1043-1054. doi: 10.1021/acsptsci.3c00328
Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2023). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal. doi: 10.1093/eurheartj/ehad793
Alexander, Stephen P. H., Mathie, Alistair A., Peters, John A., Veale, Emma L., Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M., Becirovic, Elvir, Biel, Martin, Bill, Roslyn M., Caceres, Ana I., Catterall, William A., Conner, Alex C., Davies, Paul, De Clerq, Katrien, Delling, Markus, Di Virgilio, Francesco, Falzoni, Simonetta, Fenske, Stefanie, Fortuny‐Gomez, Anna, Fountain, Samuel, George, Chandy, Goldstein, Steve A. N. ... Zhu, Michael (2023). The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. British Journal of Pharmacology, 180 (S2), S145-S222. doi: 10.1111/bph.16178
Tran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346
Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2
Kellenberger, Stephan and Rash, Lachlan D. (2023). Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1). doi: 10.2218/gtopdb/f118/2023.1
Finol-Urdaneta, Rocio K., Ziegman, Rebekah, Dekan, Zoltan, McArthur, Jeffrey R., Heitmann, Stewart, Luna-Ramirez, Karen, Tae, Han-Shen, Mueller, Alexander, Starobova, Hana, Chin, Yanni K.-Y., Wingerd, Joshua S., Undheim, Eivind A. B., Cristofori-Armstrong, Ben, Hill, Adam P., Herzig, Volker, King, Glenn F., Vetter, Irina, Rash, Lachlan D., Adams, David J. and Alewood, Paul F. (2022). Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences, 119 (5) e2110932119. doi: 10.1073/pnas.2110932119
Duggan, Nisharnthi M., Saez, Natalie J., Clayton, Daniel, Budusan, Elena, Watson, Emma E., Tucker, Isaac J., Rash, Lachlan D., King, Glenn F. and Payne, Richard J. (2021). Total synthesis of the spider-venom peptide Hi1a. Organic Letters, 23 (21) acs.orglett.1c03112, 8375-8379. doi: 10.1021/acs.orglett.1c03112
Alexander, Stephen PH, Mathie, Alistair, Peters, John A, Veale, Emma L, Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M, Becirovic, Elvir, Biel, Martin, Bill, Roslyn M., Catterall, William A., Conner, Alex C., Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, Fenske, Stefanie, George, Chandy, Goldstein, Steve A. N., Grissmer, Stephan, Ha, Kotdaji ... Zhu, Michael (2021). The concise guide to pharmacology 2021/22: ion channels. British Journal of Pharmacology, 178 (S1), S157-S245. doi: 10.1111/bph.15539
Foster, Victoria S., Rash, Lachlan D., King, Glenn F. and Rank, Michelle M. (2021). Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System. Frontiers in cellular neuroscience, 15 738043, 1-16. doi: 10.3389/fncel.2021.738043
Kellenberger, Stephan and Rash, Lachlan D. (2021). Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE, 2021 (3). doi: 10.2218/gtopdb/f118/2021.3
Cristofori-Armstrong, Ben, Budusan, Elena and Rash, Lachlan D. (2021). Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead. Proceedings of the National Academy of Sciences, 118 (8) e2021581118, 1-3. doi: 10.1073/pnas.2021581118
Kellenberger, Stephan and Rash, Lachlan D. (2020). Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2020 (5). doi: 10.2218/gtopdb/f118/2020.5
Schendel, Vanessa, Rash, Lachlan D., Jenner, Ronald A. and Undheim, Eivind A. B. (2019). The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution. Toxins, 11 (11) 666, 666. doi: 10.3390/toxins11110666
Alexander, Stephen P.H., Mathie, Alistair, Peters, John A., Veale, Emma L., Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Davies, Jamie A., Aldrich, Richard W., Becirovic, Elvir, Biel, Martin, Catterall, William A., Conner, Alex C., Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, George, Chandy, Goldstein, Steve A.N., Grissmer, Stephan, Ha, Kotdaji, Hammelmann, Verena, Hanukoglu, Israel, Jarvis, Mike ... Zhu, Michael (2019). The Concise Guide to Pharmacology 2019/20: Ion channels. British Journal of Pharmacology, 176 (S1), S142-S228. doi: 10.1111/bph.14749
Kellenberger, Stephan, Rash, Lachlan D. and Schild, Laurent (2019). Acid-sensing (proton-gated) ion channels (ASICs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019 (4). doi: 10.2218/gtopdb/f118/2019.4
Cristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F. and Rash, Lachlan D. (2019). The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochemical Pharmacology, 163, 381-390. doi: 10.1016/j.bcp.2019.03.004
Kakumanu, Rahini, Kuruppu, Sanjaya, Rash, Lachlan, Isbister, Geoffrey, Hodgson, Wayne and Kemp-Harper, Barbara (2019). D. russelii venom mediates vasodilatation of resistance like arteries via activation of Kv and KCa Channels. Toxins, 11 (4) 197, 197. doi: 10.3390/toxins11040197
Jin, Ai-hua, Cristofori-Armstrong, Ben, Rash, Lachlan D., Román González, Sergio Agustín, Espinosa, Roberto Arreguín, Lewis, Richard J., Alewood, Paul F. and Vetter, Irina (2019). Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology, 164, 342-348. doi: 10.1016/j.bcp.2019.04.025
Silva, Anjana, Cristofori-Armstrong, Ben, Rash, Lachlan D., Hodgson, Wayne C. and Isbister, Geoffrey K. (2018). Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans. Cellular and Molecular Life Sciences, 75 (23), 4465-4478. doi: 10.1007/s00018-018-2893-x
Lee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089
Wilson, David, Boyle, Glen M, McIntyre, Lachlan, Nolan, Matthew J, Parsons, Peter G, Smith, Jennifer J, Tribolet, Leon, Loukas, Alex, Liddell, Michael J, Rash, Lachlan D and Daly, Norelle L (2017). The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells. Toxins, 9 (11) 346, 1-13. doi: 10.3390/toxins9110346
Cristofori-Armstrong, Ben and Rash, Lachlan D. (2017). Acid-sensing ion channel (ASIC) structure and function: insights from spider, snake and sea anemone venoms. Neuropharmacology, 127, 173-184. doi: 10.1016/j.neuropharm.2017.04.042
Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K. -Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J. and Rash, Lachlan D. (2017). The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.. Scientific Reports, 7 (1) 974, 974. doi: 10.1038/s41598-017-01129-0
Mobli, Mehdi, Undheim, Eivind A.B. and Rash, Lachlan D. (2017). Modulation of ion channels by cysteine-rich peptides: from sequence to structure. Advances in Pharmacology, 79, 199-223. doi: 10.1016/bs.apha.2017.03.001
Er, Sing Yan, Cristofori-Armstrong, Ben, Escoubas, Pierre and Rash, Lachlan D. (2017). Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1. Neuropharmacology, 127, 185-195. doi: 10.1016/j.neuropharm.2017.03.020
Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551
Chassagnon, Irene R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D. and King, Glenn F. (2017). Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings from the National Academy of Sciences of the United States of America, 114 (14), 3750-3755. doi: 10.1073/pnas.1614728114
Vetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016). NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172, 73-100. doi: 10.1016/j.pharmthera.2016.11.015
Koehn, Liam M., Dong, Qing, Er, Sing-Yan, Rash, Lachlan D., King, Glenn F., Dziegielewska, Katarzyna M., Saunders, Norman R. and Habgood, Mark D. (2016). Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury [version 1; referees: 1 approved, 1 approved with reservations]. F1000Research, 5 1822, 1822. doi: 10.12688/F1000RESEARCH.9094.1
Koehn, Liam M, Noor, Natassya M, Dong, Qing, Er, Sing-Yan, Rash, Lachlan D, King, Glenn F, Dziegielewska, Katarzyna M, Saunders, Norman R and Habgood, Mark D (2016). Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury. F1000Research, 5 1822, 1822. doi: 10.12688/f1000research.9094.2
McCarthy, Claudia A., Rash, Lachlan D., Chassagnon, Irene R., King, Glenn F. and Widdop, Robert E. (2015). PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a. Neuropharmacology, 99 5986, 650-657. doi: 10.1016/j.neuropharm.2015.08.040
Cristofori-Armstrong, Ben, Soh, Ming S., Talwar, Sahil, Brown, Darren L., Griffin, John D. O., Dekan, Zoltan, Stow, Jennifer L., King, Glenn F., Lynch, Joseph W. and Rash, Lachlan D. (2015). Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. Scientific Reports, 5 (1) 14763, 14763.1-14763.12. doi: 10.1038/srep14763
Saez, Natalie J., Deplazes, Evelyne, Cristofori-Armstrong, Ben, Chassagnon, Irene R., Lin, Xiaozhen, Mobli, Mehdi, Mark, Alan E., Rash, Lachlan D. and King, Glenn F. (2015). Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. British Journal of Pharmacology, 172 (20), 4985-4995. doi: 10.1111/bph.13267
Chow, Chun Yuen, Cristofori-Armstrong, Ben, Undheim, Eivind A. B., King, Glenn F. and Rash, Lachlan D. (2015). Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from venom of an Australian tarantula. Toxins, 7 (7), 2494-2513. doi: 10.3390/toxins7072494
Simons, Cas, Rash, Lachlan D., Crawford, Joanna, Ma, Linlin, Cristofori-Armstrong, Ben, Miller, David, Ru, Kelin, Baillie, Gregory J., Alanay, Yasemin, Jacquinet, Adeline, Debray, Franois-Guillaume, Verloes, Alain, Shen, Joseph, Yesil, Goezde, Guler, Serhat, Yuksel, Adnan, Cleary, John G., Grimmond, Sean M., McGaughran, Julie, King, Glenn F., Gabbett, Michael T. and Taft, Ryan J. (2015). Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy (vol 47, pg 73, 2015). Nature Genetics, 47 (3), 304-304. doi: 10.1038/ng0315-304b
Simons Cas, Rash, Lachlan D., Crawford, Joanna, Ma, Linlin, Cristofori-Armstrong, Ben, Miller, David, Ru, Kelin, Baillie, Gregory J., Alanay, Yasemin, Jacquinet, Adeline, Debray, François-Guillaume, Verloes, Alain, Shen, Joseph, Yesil, Gözde, Guler, Serhat, Yuksel, Adnan, Cleary, John G., Grimmond, Sean M., McGaughran, Julie, King, Glenn F., Gabbett, Michael T. and Taft, Ryan J. (2015). Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy. Nature Genetics, 47 (1), 73-77. doi: 10.1038/ng.3153
Klint, Julie K., Berecki, Géza, Durek, Thomas, Mobli, Mehdi, Knapp, Oliver, King, Glenn F., Adams, David J., Alewood, Paul F. and Rash, Lachlan D. (2014). Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels. Biochemical Pharmacology, 89 (2), 276-286. doi: 10.1016/j.bcp.2014.02.008
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898
Jensen, Jonas E., Cristofori-Armstrong, Ben, Anangi, Raveendra, Rosengren, K. Johan, Lau, Carus H. Y., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2014). Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores. Journal of Medicinal Chemistry, 57 (21), 9195-9203. doi: 10.1021/jm501400p
Rash, Lachlan D. (2013). ASIC3: first the heartache, now a migraine!. Headache, 53 (8), 1204-1206. doi: 10.1111/head.12170
Klint, Julie K., Senff, Sebastian, Saez, Natalie J., Seshadri, Radha, Lau, Ho Yee, Bende, Nira J., Undheim, Eivind A. B., Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2013). Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli. PLoS One, 8 (5) e63865, e63865.1-e63865.12. doi: 10.1371/journal.pone.0063865
Anangi, Raveendra, Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2012). Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3. Marine Drugs, 10 (7), 1605-1618. doi: 10.3390/md10071605
Jensen, Jonas E., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2012). Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3. Marine Drugs, 10 (7), 1511-1527. doi: 10.3390/md10071511
Blanchard, Maxime G., Rash, Lachlan D. and Kellenberger, Stephan (2012). Inhibition of voltage-gated Na+ currents in sensory neurons by the sea anemone toxin APETx2. British Journal of Pharmacology, 165 (7), 2167-2177. doi: 10.1111/j.1476-5381.2011.01674.x
Saez, Natalie J., Mobli, Mehdi, Bieri, Michael, Chassagnon, Irene R., Malde, Alpeshkumar K., Gamsjaeger, Roland, Mark, Alan E., Gooley, Paul R., Rash. Lachlan D. and King, Glenn F. (2011). A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a. Molecular Pharmacology, 80 (5), 796-808. doi: 10.1124/mol.111.072207
Rash, Lachlan D., Morales, Rodrigo A.V., Vink, Simone and Alewood, Paul F. (2011). De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina). Toxicon, 57 (2), 208-216. doi: 10.1016/j.toxicon.2010.11.012
Vetter, Irina, Davis, Jasmine L., Rash, Lachlan D., Anangi, Raveendra, Mobli, Mehdi, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2011). Venomics: A new paradigm for natural products-based drug discovery. Amino Acids, 40 (1), 15-28. doi: 10.1007/s00726-010-0516-4
Seaz, Natalie J., Senff, Sebastian, Jensen, Jonas E., Er, Sing Yan, Herzig, Volker, Rash, Lachlan D. and King, Glenn F. (2010). Spider-venom peptides as therapeutics. Toxins, 2 (12), 2851-2871. doi: 10.3390/toxins2122851
Jensen, J. E., Durek, T, Alewood, P. F., Adams, D. J., King, G. F. and Rash, L. D. (2009). Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3. TOXICON, 54 (1), 56-61. doi: 10.1016/j.toxicon.2009.03.014
Rouault, Morgane, Rash, Lachlan D., Escoubas, Pierre, Boilard, Eric, Bollinger, James, Lomonte, Bruno, Maurin, Thomas, Guillaume, Carole, Canaan, Stéphane, Deregnaucourt, Christiane, Schrével, Joseph, Doglio, Alain, Gutiérrez, José María, Lazdunski, Michel, Gelb, Michael H. and Lambeau, Gérard (2006). Neurotoxicity and Other Pharmacological Activities of the Snake Venom Phospholipase A2 OS2: The N-Terminal Region Is More Important Than Enzymatic Activity. Biochemistry, 45 (18), 5800-5816. doi: 10.1021/bi060217r
Bosmans, Frank, Rash, Lachlan, Zhu, Shunyi, Diochot, Sylvie, Lazdunski, Michel, Escoubas, Pierre and Tytgat, Jan (2006). Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes. Molecular Pharmacology, 69 (2), 419-429. doi: 10.1124/mol.105.015941
Salinas, Miguel, Rash, Lachlan D., Baron, Anne, Lambeau, Gerard, Escoubas, Pierre and Lazdunski, Michel (2006). The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. Journal of Physiology, 570 (2), 339-354. doi: 10.1113/jphysiol.2005.095810
Diochot, Sylvie, Baron, Anne, Rash, Lachlan D., Deval, Emmanuel, Escoubas, Pierre, Scarzello, Sabine, Salinas, Miguel and Lazdunsk, Michel (2004). A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. The EMBO journal, 23 (7), 1516-1525. doi: 10.1038/sj.emboj.7600177
Escoubas, Pierre and Rash, Lachlan (2004). Tarantulas: eight-legged pharmacists and combinatorial chemists. Toxicon, 43 (5), 555-574. doi: 10.1016/j.toxicon.2004.02.007
Rash, Lachlan D. and Hodgson, Wayne C. (2002). Pharmacology and biochemistry of spider venoms. Toxicon, 40 (3), 225-254. doi: 10.1016/S0041-0101(01)00199-4
Rosamilla, Anthony E., Mayes, Penelope A., Papadopoulos, Roslyn, Campi, Eva M., Jackson, W. Roy, Rash, Lachlan and Jarrott, Bevyn (2002). Synthesis of Some Nefopam Analogues as Potential Analgesics. Australian Journal of Chemistry, 55 (9), 577-585. doi: 10.1071/CH02097
Rash, LD, Birinyi-Strachan, LC, Nicholson, GM and Hodgson, WC (2000). Neurotoxic activity of venom from the Australian Eastern mouse spider (Missulena bradleyi) involves modulation of sodium channel gating. British Journal of Pharmacology, 130 (8), 1817-1824. doi: 10.1038/sj.bjp.0703494
Rash, LD, King, RG and Hodgson, WC (2000). Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata). Toxicon, 38 (8), 1111-1127. doi: 10.1016/S0041-0101(99)00226-3
Rash, LD, King, RG and Hodgson, WC (1998). Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi). Toxicon, 36 (2), 367-375. doi: 10.1016/S0041-0101(97)00072-X
Conference Papers
Blanchard, Maxime, Rash, Lachlan D. and Kellenberger, Stephan (2012). Inhibition of voltage-gated Na+ currents in sensory neurons by the sea anemone toxin APETx2. 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, United States, 12-16 November 2011. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2011.11.1780
Rash, Lachlan D. (2012). Structure activity studies and therapeutic potential of venom peptides that target acid-sensing ion channels. Joint ASCEPT-APSA 2012 Conference, Sydney, Australia, 2-5 December 2012.
Mozar, C. A., Sun, T., Rash, L. D., King, G. F. and Christie, M. J. (2011). Actions of ASIC1a and ASIC3 inhibitors in rat chronic pain models. 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, United States, 12-16 November 2011.