Publications
Journal Articles
Lockie, Sarah H and Hagg, Adam (2025). Ghrelin and LEAP2: Subtle Players in Cachexia, Essential for the Bigger Picture. Endocrinology, 166 (7) bqaf093. doi: 10.1210/endocr/bqaf093
Ongaro, Luisina, Zhou, Xiang, Wang, Ying, Schultz, Hailey, Zhou, Ziyue, Buddle, Evan R. S., Brûlé, Emilie, Lin, Yeu-Farn, Schang, Gauthier, Hagg, Adam, Castonguay, Roselyne, Liu, Yewei, Su, Gloria H., Seidah, Nabil G., Ray, Kevin C., Karp, Seth J., Boehm, Ulrich, Ruf-Zamojski, Frederique, Sealfon, Stuart C., Walton, Kelly L., Lee, Se-Jin and Bernard, Daniel J. (2025). Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. Science, 387 (6731), 329-336. doi: 10.1126/science.adi4736
Hagg, Adam, O'Shea, Eliza, Harrison, Craig A. and Walton, Kelly Louise (2023). Targeting activins and inhibins to treat reproductive disorders and cancer cachexia. Journal of Endocrinology, 258 (1) e220290, 1-15. doi: 10.1530/joe-22-0290
Sartori, Roberta, Hagg, Adam, Zampieri, Sandra, Armani, Andrea, Winbanks, Catherine E., Viana, Lais R., Haidar, Mouna, Watt, Kevin, Qian, Hongwei, Pezzini, Camilla, Zanganeh, Pardis, Turner, Bradley J., Larsson, Anna, Zanchettin, Gianpietro, Pierobon, Elisa S., Moletta, Lucia, Valmasoni, Michele, Ponzoni, Alberto, Attar, Shady, Da Dalt, Gianfranco, Sperti, Cosimo, Kustermann, Monika, Thomson, Rachel E., Larsson, Lars, Loveland, Kate L., Costelli, Paola, Megighian, Aram, Merigliano, Stefano, Penna, Fabio ... Sandri, Marco (2021). Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia. Science Translational Medicine, 13 (605) eaay9592. doi: 10.1126/scitranslmed.aay9592
Watt, K., Henstridge, D. C., Ziemann, M., Sim, C. B., Montgomery, M. K., Samocha-Bonet, D., Parker, B. L., Dodd, G. T., Bond, S. T., Salmi, T. M., Lee, R. S., Thomson, R. E., Hagg, A., Davey, J. R., Qian, H., Koopman, R., El-Osta, A., Greenfield, J. R., Watt, M. J., Febbraio, M. A., Drew, B. G., Cox, A. G., Porrello, E. R., Harvey, K. F. and Gregorevic, P. (2021). Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nature Communications, 12 (1) 2887. doi: 10.1038/s41467-021-23240-7
Goodman, Craig A., Davey, Jonathan R., Hagg, Adam, Parker, Benjamin L. and Gregorevic, Paul (2021). Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β. Molecular and Cellular Proteomics, 20 100050, 100050. doi: 10.1016/j.mcpro.2021.100050
Hagg, Adam, Kharoud, Swati, Goodchild, Georgia, Goodman, Craig A., Chen, Justin L., Thomson, Rachel E., Qian, Hongwei, Gregorevic, Paul, Harrison, Craig A. and Walton, Kelly L. (2020). TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass. Frontiers in Physiology, 11 560225, 560225. doi: 10.3389/fphys.2020.560225
Davey, Jonathan R., Estevez, Emma, Thomson, Rachel E., Whitham, Martin, Watt, Kevin I., Hagg, Adam, Qian, Hongwei, Henstridge, Darren C., Ludlow, Helen, Hedger, Mark P., McGee, Sean L., Coughlan, Melinda T., Febbraio, Mark A. and Gregorevic, Paul (2020). Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes. The FASEB Journal, 34 (4), 5697-5714. doi: 10.1096/fj.201802059rrr
Walton, Kelly L., Chen, Justin L., Arnold, Quinn, Kelly, Emily, La, Mylinh, Lu, Louis, Lovrecz, George, Hagg, Adam, Colgan, Timothy D., Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2019). Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice. Endocrinology, 160 (10), 2417-2426. doi: 10.1210/en.2019-00257
Walker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A. and Thompson, Thomas B. (2018). Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, 115 (5), E866-E875. doi: 10.1073/pnas.1714622115
Chen, Justin L., Walton, Kelly L., Hagg, Adam, Colgan, Timothy D., Johnson, Katharine, Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2017). Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), E5266-E5275. doi: 10.1073/pnas.1620013114
Chen, Justin L., Walton, Kelly L., Qian, Hongwei, Colgan, Timothy D., Hagg, Adam, Watt, Matthew J., Harrison, Craig A. and Gregorevic, Paul (2016). Differential effects of IL6 and activin A in the development of cancer-associated cachexia. Cancer Research, 76 (18), 5372-5382. doi: 10.1158/0008-5472.CAN-15-3152
Winbanks, Catherine E., Murphy, Kate T., Bernardo, Bianca C., Qian, Hongwei, Liu, Yingying, Sepulveda, Patricio V., Beyer, Claudia, Hagg, Adam, Thomson, Rachel E., Chen, Justin L., Walton, Kelly L., Loveland, Kate L., McMullen, Julie R., Rodgers, Buel D., Harrison, Craig A., Lynch, Gordon S. and Gregorevic, Paul (2016). Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Science Translational Medicine, 8 (348) 348ra98. doi: 10.1126/scitranslmed.aac4976
Hagg, Adam, Colgan, Timothy D., Thomson, Rachel E., Qian, Hongwei, Lynch, Gordon S. and Gregorevic, Paul (2016). Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size. Scientific Reports, 6 (1) 23042, 23042. doi: 10.1038/srep23042
Sepulveda, Patricio V., Lamon, Severine, Hagg, Adam, Thomson, Rachel E., Winbanks, Catherine E., Qian, Hongwei, Bruce, Clinton R., Russell, Aaron P. and Gregorevic, Paul (2015). Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy. Scientific Reports, 5 (1) 17535, 17535. doi: 10.1038/srep17535
Watt, K. I., Turner, B. J., Hagg, A., Zhang, X., Davey, J. R., Qian, H., Beyer, C., Winbanks, C. E., Harvey, K. F. and Gregorevic, P. (2015). The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size. Nature Communications, 6 (1) 6048, 6048. doi: 10.1038/ncomms7048
Winbanks, Catherine E., Beyer, Claudia, Hagg, Adam, Qian, Hongwei, Sepulveda, Patricio V. and Gregorevic, Paul (2013). miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4. PLoS One, 8 (9) e73589, e73589. doi: 10.1371/journal.pone.0073589