School of Biomedical Sciences

Dr Oliver Rawashdeh

Sr. Lecturer in Biomedical Sciences
School of Biomedical Sciences
+61 7 336 52706
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Oliver leads the Chronobiology and sleep group.

Available PhD projects

Deciphering the role of clock genes in the transduction of photic information to the master biological clock

Project:

The project aims to identify the components and mechanistics involved in resetting the body’s master circadian clock in the suprachiasmatic nucleus. A detailed understanding of how time-cues entrain the biological clock will be key to develop pharmacological approaches that are aimed to enhance our adaptability to temporal environmental changes i.e. adjusting the speed by which our clocks tick.

Background:

Jetlag and Social-lag are terms used to describe symptoms associated with the disruption of the body’s “internal clock”. This disruption, or desynchronosis, can occur (1) when flying across multiple time zones, (2) during shiftwork, (3) due to a misalgnment between the body’s internal clock and social time and (4) in diseases and during ageing. The symptoms include loss of appetite, insomnia, mild depression, altered mood, headaches, nausea and reduced physical and mental performance. Jetlag symptoms gradually wear off as the body adapts to the new time zone and social cycles. Thus, accelerating the adaptation process or reinstating circadian rhythms in disease and during ageing means reducing symptomatology and improving the quality of life.

Scholarship:

This project is fully funded and inlcudes a scholarship top-up.

Sleep and circadian dysfunction in neurodegenerative diseases

Project:

We have a long-term interdisciplinary research program to study sleep and circadian rhythms in neurodegenerative disorders. The expertise of our collaborative groups spans from chronobiology, neuroscience, pharmacology, to engineering and maths. Together we are working on urgent translational research questions. We are seeking highly motivated, curiosity-driven students interested in joining the team to pursue a Ph.D. in Neuroscience in the area of sleep and circadian rhythms in neurodegeneration and related therapeutic avenues. The Ph.D. candidates will take interest and leadership in formulating scientific questions, develop new techniques, and mechanistic/therapeutic solutions. Training to design experiments and learn new methods will be provided. The Ph.D. candidate will be supported by lab staff. Unique lab skills in emerging fields and initiatives within the broad framework are welcomed.

Educational background:

A BSc. Honours (Class1) or MSc. in science, biomedical sciences, biomedical engineering, neurosciences, biochemistry, or related disciplines is required. Candidates with experience in small animal neuroscience research, biochemistry, animal behaviour, are strongly encouraged to apply.

Scholarship:

This project is fully funded and includes a scholarship and top-up funds.

Modelling the interaction between sleep and the biological clock in health and disease

Project:

We have a long-term interdisciplinary research program to study sleep and circadian rhythms in health and disease (e.g., neurodegenerative disorders). The expertise of our collaborative groups spans from chronobiology, neuroscience, and pharmacology. Together we are working on urgent translational research questions. For this project, we are seeking a highly motivated, curiosity-driven student interested in the Neuroscience of sleep and circadian rhythms, specifically on the mathematical modeling of the regulatory interaction between the biological clock and sleep in health and disease. The Ph.D. candidate will take interest and leadership in formulating scientific questions, develop new techniques, and mechanistic/therapeutic solutions. Training to design experiments and learn new methods will be provided. The Ph.D. candidate will be supported by lab staff. We welcome unique lab skills in emerging fields and initiatives within the broad framework.

Educational background:

A bachelor’s in Science, BioMed, Mathematics, Engineering, and Computer science are welcome.

Scholarship:

This project is fully funded, scholarships and top-up funds are also available.

Researcher biography

I received my Bachelor's in Biology (2001) from Yarmouk University in Jordan, followed by postgraduate degrees from the University of Houston in Houston-Texas (2002-2007). My studies are integrative in nature, joining the best of both the Neuroscience world and Circadian Biology (the study of biological clocks). In the laboratory of Prof. Arnold Eskin, I investigated how processes as complex as learning and memory are modulated by biological clocks i.e. the circadian (about 24 hours) system, using Aplysia californica as the experimental model. After completing my Master's in Science in 2005, my research focused on the mechanism by which biological clocks modulate learning and memory. This work was performed in the laboratories of Prof. Gregg Cahill and Prof. Greg Roman, experts in chronobiology and behavioral neuroscience, respectively. Using Zebrafish as a model system, I investigated the role of melatonin, a night-time restricted hormonal signal, in modulating long-term memory consolidation. My findings, published in Science in 2007, shows that the circadian system via the cyclic night-time confined synthesis/release of melatonin “the hormone of darkness” functions as a modulator, shaping daily variations in the efficiency by which memories are processed. After receiving my Ph.D. in 2007, I joined as a postdoctoral fellow the laboratory of the pharmacologist and melatonin researcher Prof. Margarita Dubocovich. My postdoctoral work engaged in elucidating the role of melatonin in circadian physiology and pharmacology during development and ageing in rodents (Mus musculus) and non-human primates (Macaca mulatta) at the Feinberg School of Medicine (Northwestern University-Chicago) and the State University of New York (SUNY). From 2010-2015, I held a teaching/research position in the Dr. Senckenbergische Anatomy and the Dept. of Neurology at the Goethe University in Frankfurt-Germany. During this time, I was involved in teaching gross human anatomy while continuing my endeavor in understanding the mechanistics involved in shaping memory processes (acquisition, consolidation and retrieval) by the circadian system.

Publications

Journal Articles (36)
Conference Papers (4)
Preprint (1)

Journal Articles

Klyne, David M., Hilliard, Brendan A., Harris, Michele Y., Amin, Mamta, Hall, Michelle, Besomi, Manuela, Mustafa, Sanam, Farrell, Scott F., Rawashdeh, Oliver, Han, Felicity Y., Hodges, Paul W., Frara, Nagat and Barbe, Mary F. (2024). Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury. Brain, Behavior, & Immunity - Health, 35 100714, 100714. doi: 10.1016/j.bbih.2023.100714
de Assis, Leonardo Vinicius Monteiro, Harder, Lisbeth, Lacerda, José Thalles, Parsons, Rex, Kaehler, Meike, Cascorbi, Ingolf, Nagel, Inga, Rawashdeh, Oliver, Mittag, Jens and Oster, Henrik (2024). Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice. Scientific Reports, 14 (1) 640, 1-12. doi: 10.1038/s41598-023-50374-z
Shaikh, Samreen N., Willis, Emily F., Dierich, Max, Xu, Yi, Stuart, Samuel J. S., Gobe, Glenda C., Bashaw, Abate A., Rawashdeh, Oliver, Kim, Seung Jae and Vukovic, Jana (2023). CSF-1R inhibitor PLX3397 attenuates peripheral and brain chronic GVHD and improves functional outcomes in mice. Journal of Neuroinflammation, 20 (1) 300, 300. doi: 10.1186/s12974-023-02984-7
Feigl, Beatrix, Lewis, Simon J. G. and Rawashdeh, Oliver (2023). Targeting sleep and the circadian system as a novel treatment strategy for Parkinson’s disease. Journal of Neurology, 271 (3), 1483-1491. doi: 10.1007/s00415-023-12073-7
Kunz, Dieter, Oster, Henrik, Rawashdeh, Oliver, Neumann, Wolf‐Julian, Münte, Thomas and Berg, Daniela (2023). Sleep and circadian rhythms in α‐synucleinopathies—perspectives for disease modification. Acta Physiologica, 238 (1) e13966, 1-11. doi: 10.1111/apha.13966
Qian, Lei, Rawashdeh, Oliver, Kasas, Leda, Milne, Michael R., Garner, Nicholas, Sankorrakul, Kornraviya, Marks, Nicola, Dean, Matthew W., Kim, Pu Reum, Sharma, Aanchal, Bellingham, Mark C. and Coulson, Elizabeth J. (2022). Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease. Nature Communications, 13 (1) 6543, 1-18. doi: 10.1038/s41467-022-33624-y
Boots, Rob, Xue, George, Tromp, Dirk, Rawashdeh, Oliver, Bellapart, Judith, Townsend, Shane, Rudd, Michael, Winter, Craig, Mitchell, Gary, Garner, Nicholas, Clement, Pierre, Karamujic, Nermin and Zappala, Christopher (2022). Circadian rhythmicity of vital signs at intensive care unit discharge and outcome of traumatic brain injury. American Journal of Critical Care, 31 (6), 472-482. doi: 10.4037/ajcc2022821
de Assis, Leonardo Vinícius Monteiro, Harder, Lisbeth, Lacerda, José Thalles, Parsons, Rex, Kaehler, Meike, Cascorbi, Ingolf, Nagel, Inga, Rawashdeh, Oliver, Mittag, Jens and Oster, Henrik (2022). Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation. eLife, 11, 1-35. doi: 10.7554/ELIFE.79405
Hunt, Jeremy, Coulson, Elizabeth J., Rajnarayanan, Rajendram, Oster, Henrik, Videnovic, Aleksandar and Rawashdeh, Oliver (2022). Sleep and circadian rhythms in Parkinson’s disease and preclinical models. Molecular Neurodegeneration, 17 (1) 2, 2. doi: 10.1186/s13024-021-00504-w
Boots, Rob, Mead, Gabrielle, Rawashdeh, Oliver, Bellapart, Judith, Townsend, Shane, Paratz, Jenny, Garner, Nicholas, Clement, Pierre and Oddy, David (2022). Temperature profile and adverse outcomes after discharge from the intensive care unit. American Journal of Respiratory and Critical Care Medicine, 31 (1), e1-e9. doi: 10.4037/ajcc2022223
Börner, Jan Hendrik, Rawashdeh, Oliver and Rami, Abdelhaq (2021). Exacerbated age-related hippocampal alterations of microglia morphology, β-amyloid and lipofuscin deposition and presenilin overexpression in Per1−/−-mice. Antioxidants, 10 (9) 1330. doi: 10.3390/antiox10091330
Goh, Grace H., Mark, Peter J., Blache, Dominique, Binks, Daniel, Parsons, Rex, Rawashdeh, Oliver and Maloney, Shane K. (2021). Diet-altered body temperature rhythms are associated with altered rhythms of clock gene expression in peripheral tissues in vivo. Journal of Thermal Biology, 100 102983, 102983. doi: 10.1016/j.jtherbio.2021.102983
Boots, Rob J., Mead, Gabrielle, Garner, Nicolas, Rawashdeh, Oliver, Bellapart, Judith, Townsend, Shane, Paratz, Jenny, Clement, Pierre, Oddy, David, Leong, Matthew and Zappala, Christopher (2021). Temperature rhythms and ICU sleep: the TRIS study. Minerva Anestesiologica, 87 (7), 794-802. doi: 10.23736/S0375-9393.21.15232-0
Daubner, Johanna, Arshaad, Muhammad Imran, Henseler, Christina, Hescheler, Jürgen, Ehninger, Dan, Broich, Karl, Rawashdeh, Oliver, Papazoglou, Anna and Weiergräber, Marco (2021). Pharmacological neuroenhancement: current aspects of categorization, epidemiology, pharmacology, drug development, ethics, and future perspectives. Neural Plasticity, 2021 8823383, 8823383-27. doi: 10.1155/2021/8823383
Boots, Rob, Mead, Gabrielle, Rawashdeh, Oliver, Bellapart, Judith, Townsend, Shane, Paratz, Jenny, Garner, Nicholas, Clement, Pierre and Oddy, David (2020). Circadian hygiene in the ICU environment (CHIE) study. Critical Care and Resuscitation, 22 (4) 4, 361-369.
Boots, Rob, Mead, Gabrielle, Rawashdeh, Oliver, Bellapart, Judith, Townsend, Shane, Paratz, Jenny, Garner, Nicholas, Clement, Pierre, Oddy, David and On behalf of the Circadian Investigators in Critical Illness (2020). Circadian Hygiene in the ICU Environment (CHIE) study. Critical Care and Resuscitation, 22 (4), 361-369. doi: 10.51893/2020.4.oa9
Parsons, Rex, Parsons, Richard, Garner, Nicholas, Oster, Henrik and Rawashdeh, Oliver (2020). CircaCompare: a method to estimate and statistically support differences in mesor, amplitude and phase, between circadian rhythms. Bioinformatics, 36 (4), 1208-1212. doi: 10.1093/bioinformatics/btz730
Pilorz, Violetta, Astiz, Mariana, Heinen, Keno Ole, Rawashdeh, Oliver and Oster, Henrik (2020). The concept of coupling in the mammalian circadian clock-network. Journal of Molecular Biology, 432 (12), 3618-3638. doi: 10.1016/j.jmb.2019.12.037
Weger, Benjamin D., Rawashdeh, Oliver and Gachon, Frédéric (2019). At the intersection of microbiota and circadian clock: are sexual dimorphism and growth hormones the missing link to pathology? Circadian clock and microbiota: potential egffect on growth hormone and sexual development. BioEssays, 41 (9) 1900059, e1900059. doi: 10.1002/bies.201900059
Lucia, D., Burgess, D., Cullen, C. L., Dorey, E. S., Rawashdeh, O. and Moritz, K. M. (2019). Periconceptional maternal alcohol consumption leads to behavioural changes in adult and aged offspring and alters the expression of hippocampal genes associated with learning and memory and regulators of the epigenome. Behavioural Brain Research, 362, 249-257. doi: 10.1016/j.bbr.2019.01.009
Kim, Pureum, Oster, Henrik, Lehnert, Hendrik, Schmid, Sebastian M, Salamat, Nicole, Barclay, Johanna L, Maronde, Erik, Inder, Warrick and Rawashdeh, Oliver (2019). Coupling the circadian clock to homeostasis: the role of Period in timing physiology. Endocrine Reviews, 40 (1), 66-95. doi: 10.1210/er.2018-00049
Himmelhan, D. K., Rawashdeh, O. and Oelschläger, H. H. A. (2018). Early postnatal development of the visual cortex in mice with retinal degeneration. Mechanisms of Development, 151, 1-9. doi: 10.1016/j.mod.2018.03.002
Rawashdeh, Oliver, Parsons, Rex and Maronde, Erik (2018). Clocking in time to gate memory processes: the circadian clock is part of the ins and outs of memory. Neural Plasticity, 2018 6238989, 6238989-11. doi: 10.1155/2018/6238989
Rawashdeh, Oliver, Clough, Shannon J. , Hudson, Randall L. and Dubocovich, Margarita L. (2017). Learned motivation drives circadian physiology in the absence of the master circadian clock. FASEB Journal, 31 (1), 388-399. doi: 10.1096/fj.201600926R
Rami, Abdalhaq, Fekadu, Julia and Rawashdeh, Oliver (2017). The hippocampal autophagic machinery is depressed in the absence of the circadian clock protein PER1 that may lead to vulnerability during cerebral ischemia. Current Neurovascular Research, 14 (3), 207-214. doi: 10.2174/1567202614666170619083239
Rawashdeh, Oliver, Jilg, Antje, Maronde, Erik, Fahrenkrug, Jan and Stehle, Joerg H. (2016). Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK. Journal of Neurochemistry, 138 (5), 731-745. doi: 10.1111/jnc.13689
Stehle, Jorg H. and Rawashdeh, Oliver (2016). Ribosomal RNA - A tail wagging the dog?. Journal of Neurochemistry, 136 (4), 673-676. doi: 10.1111/jnc.13499
Rawashdeh, Oliver, Jilg, Antje, Jedlicka, Peter, Slawska, Jolanta, Thomas, Lukas, Saade, Anastasia, Schwarzacher, Stephan W. and Stehle, Joerg H. (2014). PERIOD1 coordinates hippocampal rhythms and memory processing with daytime. Hippocampus, 24 (6), 712-723. doi: 10.1002/hipo.22262
Rawashdeh, Oliver and Dubocovich, Margarita L. (2014). Long-term effects of maternal separation on the responsiveness of the circadian system to melatonin in the diurnal nonhuman primate (Macaca mulatta). Journal of Pineal Research, 56 (3), 254-263. doi: 10.1111/jpi.12118
Rawashdeh, Oliver and Maronde, Erik (2012). The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing. Frontiers in Molecular Neuroscience, 5 (FEBRUARY 2012), 1-6. doi: 10.3389/fnmol.2012.00027
Stehle, Joerg H., Saade, Anastasia, Rawashdeh, Oliver, Ackermann, Katrin, Jilg, Antje, Sebesteny, Tamas and Maronde, Erik (2011). A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases. Journal of Pineal Research, 51 (1), 17-43. doi: 10.1111/j.1600-079X.2011.00856.x
Rawashdeh, Oliver, Hudson, Randall L., Stepien, Iwona and Dubocovich, Margarita L. (2011). Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3HHeN mice. Chronobiology International, 28 (1), 31-38. doi: 10.3109/07420528.2010.532894
Rawashdeh, Oliver and Stehle, Joerg H. (2010). Ageing or NOT, clock genes are important for memory processes: an interesting hypothesis raising many questions. Aging, 2 (5), 259-260. doi: 10.18632/aging.100148
Rawashdeh, Oliver, de Borsetti, Nancy Hernandez, Roman, Gregg and Cahill, Gregory M. (2007). Melatonin suppresses nighttime memory formation in zebrafish. Science, 318 (5853), 1144-1146. doi: 10.1126/science.1148564
Lyons, Lisa C., Rawashdeh, Oliver and Eskin, Arnold (2006). Non-ocular circadian oscillators and photoreceptors modulate long term memory formation in Aplysia. Journal of Biological Rhythms, 21 (4), 245-255. doi: 10.1177/0748730406289890
Lyon, Lisa C., Rawashdeh, Oliver, Katzoff, Ayelet, Susswein, Abraham J. and Eskin, Arnold (2005). Circadian modulation of complex learning in diurnal and nocturnal Aplysia. Proceedings of the National Academy of Sciences of the United States of America, 102 (35), 12589-12594. doi: 10.1073/pnas.0503847102

Conference Papers

Wing, M. J., Burgess, Di., Lucia, D., Rawashdeh, O. and Moritz, K. M. (2018). Alterations to circadian rhythms of blood glucose and plasma corticosterone in rat offspring following exposure to alcohol around conception. 41st Annual Scientific Meeting of the Research Society on Alcoholism, San Diego, California, 16-20 June 2018 . Malden, MA, United States: Wiley-Blackwell .
Lucia, D., Burgess, D. J., Cullen, C. L., Rawashdeh, O. and Moritz, K. M. (2018). Maternal alcohol consumption around conception leads to sex specific behavioural changes in rat offspring. 41st Annual Scientific Meeting of the Research Society on Alcoholism, San Diego, CA, United States, 16-20 June 2018. Malden, MA, United States: Wiley-Blackwell.
Wing, Michael J. E., Burgess, Danielle, Zanfirache, Diana, Rawashdeh, Oliver and Moritz, Karen (2018). Periconceptional alcohol exposure results in sex-specific alterations to circadian rhythms of blood glucose and plasma corticosterone in rat offspring. Joint Annual Scientific Meetings of the Endocrine Society of Australia and the Society for Reproductive Biology 2017, Perth, WA, Australia, 27-30 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/cen.13727
Gerstner, Jason R., Lyons, Lisa C., Wright, Kenneth P., Jr., Loh, Dawn H., Rawashdeh, Oliver, Eckel-Mahan, Kristin L. and Roman, Gregg W. (2009). Cycling behavior and memory formation. Washington, DC United States: Society for Neuroscience. doi: 10.1523/JNEUROSCI.3353-09.2009

Preprint

Fonseka, Sachini, Weger, Benjamin D., Weger, Meltem, Martel, Nick, Hall, Thomas Edward, Varasteh Moradi, Shayli, Gabriel, Christian H., Kramer, Achim, Ferguson, Charles, Fernández-Rojo, Manuel A., Alexandrov, Kirill, Rawashdeh, Oliver, McMahon, Kerrie-Ann, Gachon, Frederic and Parton, Robert G. (2022). A role for caveolar proteins in regulation of the circadian clock.