Associate Professor Lisa Kaminskas

Ascher, David B., Kaminskas, Lisa M., Myung, Yoochan and Pires, Douglas E. V. (2022). Using graph-based signatures to guide rational antibody engineering. Computer-aided antibody design. (pp. 375-397) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-2609-2_21

Pires, Douglas E. V., Kaminskas, Lisa M. and Ascher, David B. (2018). Prediction and optimization of pharmacokinetic and toxicity properties of the ligand. Computational Drug Discovery and Design. (pp. 271-284) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-7756-7_14

Feeney, Orlagh, Caliph, Suzanne M., Porter, Christopher J.H. and Kaminskas, Lisa M. (2016). Impact of physicochemical properties on dendrimer pharmacokinetics and biodistribution. Dendrimers in nanomedicine. (pp. 311-351) edited by Delphine Felder-Flesch. Singapore: Pan Stanford Publishing. doi: 10.1201/9781315364513-9

Ibrahim, Jibriil P., Dao, Nam, Haque, Shadabul, Phipps, Simon, Whittaker, Michael R. and Kaminskas, Lisa M. (2024). Hydrogenated soy phosphatidylcholine liposomes stimulate differential expression of chemokines and cytokines by rat alveolar macrophages in vitro. Journal of Pharmaceutical Sciences, 113 (5), 1395-1400. doi: 10.1016/j.xphs.2024.03.001

Subasic, Christopher N., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2024). A PEGylated liposomal formulation of prochlorperazine that limits brain exposure but retains dynamin II activity: A potential adjuvant therapy for cancer patients receiving chemotherapeutic mAbs. Nanomedicine: Nanotechnology, Biology and Medicine, 56 102733, 1-8. doi: 10.1016/j.nano.2024.102733

Kaminskas, Lisa M., Butcher, Neville J., Subasic, Christopher N., Kothapalli, Ashok, Haque, Shadabul, Grace, James L., Morsdorf, Alexander, Blanchfield, Joanne T., Whittaker, Andrew K., Quinn, John F. and Whittaker, Michael R. (2024). Lipidated brush-PEG polymers as low molecular weight pulmonary drug delivery platforms. Expert Opinion On Drug Delivery, 21 (1), 151-167. doi: 10.1080/17425247.2024.2305116

Haque, Shadabul and Kaminskas, Lisa M. (2024). The emergence of inhalable RNA therapeutics and challenges faced - where to from here?. Nanomedicine, 1-3. doi: 10.1080/17435889.2024.2429368

Ediriweera, Gayathri R., Butcher, Neville J., Kothapalli, Ashok, Zhao, Jiacheng, Blanchfield, Joanne T., Subasic, Christopher N., Grace, James L., Fu, Changkui, Tan, Xiao, Quinn, John F., Ascher, David B., Whittaker, Michael R., Whittaker, Andrew K. and Kaminskas, Lisa M. (2024). Lipid sulfoxide polymers as potential inhalable drug delivery platforms with differential albumin binding affinity. Biomaterials Science, 12 (11), 2978-2992. doi: 10.1039/d3bm02020g

Subasic, Christopher N., Butcher, Neville J., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2023). Dose-dependent effect of phenothiazines as dynamin II inhibitors on the uptake of PEGylated liposomes by endocytic cells and in vivo pharmacokinetics of PEGylated liposomal doxorubicin in rats. Molecular Pharmaceutics, 20 (9), 4468-4477. doi: 10.1021/acs.molpharmaceut.3c00102

Ibrahim, Jibriil P., Butcher, Neville J., Kothapalli, Ashok, Subasic, Christopher N., Blanchfield, Joanne T., Whittaker, Andrew K., Whittaker, Michael R and Kaminskas, Lisa M. (2023). Utilization of endogenous albumin trafficking pathways in the lungs has potential to modestly increase the lung interstitial access and absorption of drug delivery systems after inhaled administration. Expert Opinion on Drug Delivery, 20 (8), 1145-1155. doi: 10.1080/17425247.2023.2244881

Subasic, Christopher N., Butcher, Neville J., Minchin, Rodney F. and Kaminskas, Lisa M. (2023). Dose-dependent production of anti-PEG IgM after intramuscular PEGylated-hydrogenated soy phosphatidylcholine liposomes, but not lipid nanoparticle formulations of DNA, correlates with the plasma clearance of PEGylated liposomal doxorubicin in rats. Molecular Pharmaceutics, 20 (7), 3494-3504. doi: 10.1021/acs.molpharmaceut.3c00104

Murray, Margaret, Barlow, Christopher K., Blundell, Scott, Buecking, Mark, Gibbon, Anne, Goeckener, Bernd, Kaminskas, Lisa M., Leitner, Patricia, Selby-Pham, Sophie, Sinclair, Andrew, Waktola, Habtewold D., Williamson, Gary and Bennett, Louise E. (2023). Demonstrating a link between diet, gut microbiota and brain: 14C radioactivity identified in the brain following gut microbial fermentation of 14C-radiolabeled tyrosine in a pig model. Frontiers in Nutrition, 10 1127729, 1-14. doi: 10.3389/fnut.2023.1127729

Ibrahim, Jibriil P., Haque, Shadabul, Bischof, Robert J., Whittaker, Andrew K., Whittaker, Michael R. and Kaminskas, Lisa M. (2022). Liposomes are poorly absorbed via lung lymph after inhaled administration in sheep. Frontiers in Pharmacology, 13 880448, 1-9. doi: 10.3389/fphar.2022.880448

Marasini, Nirmal, Er, Gerald, Fu, Changkui, Subasic, Christopher N., Ibrahim, Jibriil, Skwarczynski, Mariusz, Toth, Istvan, Whittaker, Andrew K. and Kaminskas, Lisa M. (2022). Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis. Acta Biomaterialia, 142, 298-307. doi: 10.1016/j.actbio.2022.01.054

Subasic, Christopher N., Ardana, Aditya, Chan, Linda J., Huang, Fei, Scoble, Judith A., Butcher, Neville J., Meagher, Laurence, Chiefari, John, Kaminskas, Lisa M. and Williams, Charlotte C. (2021). Poly(HPMA-co-NIPAM) copolymer as an alternative to polyethylene glycol-based pharmacokinetic modulation of therapeutic proteins. International Journal of Pharmaceutics, 608 121075, 121075. doi: 10.1016/j.ijpharm.2021.121075

Subasic, Christopher N., Kuilamu, Esther, Cowin, Gary, Minchin, Rodney F. and Kaminskas, Lisa M. (2021). The pharmacokinetics of PEGylated liposomal doxorubicin are not significantly affected by sex in rats or humans, but may be affected by immune dysfunction. Journal of Controlled Release, 337, 71-80. doi: 10.1016/j.jconrel.2021.07.006

Dao, Nam V., Ercole, Francesca, Li, Yuhuan, Davis, Thomas P., Kaminskas, Lisa M., Sloan, Erica K., Quinn, John F. and Whittaker, Michael R. (2021). Nitroxide-functional PEGylated nanostars arrest cellular oxidative stress and exhibit preferential accumulation in co-cultured breast cancer cells. Journal of Materials Chemistry B, 9 (37), 7805-7820. doi: 10.1039/d1tb00812a

Li, Mengdie, Kaminskas, Lisa M. and Marasini, Nirmal (2021). Recent advances in nano/microparticle-based oral vaccines. Journal of Pharmaceutical Investigation, 51 (4), 1-14. doi: 10.1007/s40005-021-00537-9

Brundel, Daniel H.S., Feeney, Orlagh M., Nowell, Cameron J., Suys, Estelle J.A., Gracia, Gracia, Kaminskas, Lisa M., McIntosh, Michelle M., Kang, David W. and Porter, Christopher J.H. (2021). Depolymerization of hyaluronan using PEGylated human recombinant hyaluronidase promotes nanoparticle tumor penetration. Nanomedicine, 16 (4), 275-292. doi: 10.2217/nnm-2020-0433

Wang, Lili, Butcher, Neville J, Minchin, Rodney F and Kaminskas, Lisa M (2021). Monocytes do not contribute to sex differences seen in the pharmacokinetics of pegylated liposomal doxorubicin. Journal of Pharmaceutical Sciences, 110 (8), 3099-3101. doi: 10.1016/j.xphs.2021.05.009

Dao, Nam V., Ercole, Francesca, Urquhart, Matthew C., Kaminskas, Lisa M., Nowell, Cameron J., Davis, Thomas P., Sloan, Erica K., Whittaker, Michael R. and Quinn, John F. (2021). Trisulfide linked cholesteryl PEG conjugate attenuates intracellular ROS and collagen-1 production in a breast cancer co-culture model. Biomaterials Science, 9 (3), 835-846. doi: 10.1039/d0bm01544j

Dao, Nam V., Ercole, Francesca, Kaminskas, Lisa M., Davis, Thomas P., Sloan, Erica K., Whittaker, Michael R. and Quinn, John F. (2020). Trisulfide-bearing PEG brush polymers donate hydrogen sulfide and ameliorate cellular oxidative stress. Biomacromolecules, 21 (12), 5292-5305. doi: 10.1021/acs.biomac.0c01347

Marasini, Nirmal, Fu, Changkui, Fletcher, Nicholas L., Subasic, Christopher, Er, Gerald, Mardon, Karine, Thurecht, Kristofer J., Whittaker, Andrew K. and Kaminskas, Lisa M. (2020). The impact of polymer size and cleavability on the intravenous pharmacokinetics of PEG-based hyperbranched polymers in rats. Nanomaterials, 10 (12) 2452, 1-16. doi: 10.3390/nano10122452

Haque, Shadabul, Pouton, Colin W., McIntosh, Michelle P., Ascher, David B, Keizer, David W, Whittaker, Michael R. and Kaminskas, Lisa M. (2020). The impact of size and charge on the pulmonary pharmacokinetics and immunological response of the lungs to PLGA nanoparticles after intratracheal administration to rats. Nanomedicine: Nanotechnology, Biology, and Medicine, 30 102291, 102291. doi: 10.1016/j.nano.2020.102291

Kuilamu, Esther, Subasic, Christopher, Cowin, Gary J., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2020). Cetuximab exhibits sex differences in lymphatic exposure after intravenous administration in rats in the absence of differences in plasma exposure. Pharmaceutical Research, 37 (11) 224, 1-12. doi: 10.1007/s11095-020-02945-2

Feeney, Orlagh M., Gracia, Gracia, Brundel, Daniel H. S., Trevaskis, Natalie L., Cao, Enyuan, Kaminskas, Lisa M. and Porter, Christopher J. H. (2020). Lymph-directed immunotherapy – harnessing endogenous lymphatic distribution pathways for enhanced therapeutic outcomes in cancer. Advanced Drug Delivery Reviews, 160, 115-135. doi: 10.1016/j.addr.2020.10.002

Kaminskas, Lisa M, Landersdorfer, Cornelia B, Bischof, Robert J, Leong, Nathania, Ibrahim, Jibriil, Davies, Andrew N, Pham, Stephen, Beck, Steven, Montgomery, A. Bruce and Surber, Mark W (2019). Aerosol pirfenidone pharmacokinetics after inhaled delivery in sheep: a viable approach to treating idiopathic pulmonary fibrosis. Pharmaceutical Research, 37 (1) 3, 3. doi: 10.1007/s11095-019-2732-2

Kaminskas, Lisa M., Pires, Douglas E. V. and Ascher, David B. (2019). dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction. Scientific Reports, 9 (1) 15465, 15465. doi: 10.1038/s41598-019-51789-3

Haque, Shadabul, Feeney, Orlagh, Meeusen, Els, Boyd, Ben J., McIntosh, Michelle P., Pouton, Colin W., Whittaker, Michael and Kaminskas, Lisa M. (2019). Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats. Journal of Controlled Release, 307, 32-43. doi: 10.1016/j.jconrel.2019.05.043

Wang, Lili, Subasic, Christopher, Minchin, Rodney F. and Kaminskas, Lisa M. (2019). Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastases. Nanomedicine, 14 (12), 1605-1621. doi: 10.2217/nnm-2018-0478

Kaminskas, Lisa M., Williams, Charlotte C., Leong, Nathania J., Chan, Linda J., Butcher, Neville J., Feeney, Orlagh M., Porter, Christopher J.H., Tyssen, David, Tachedjian, Gilda and Ascher, David B. (2019). A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats. European Journal of Pharmaceutics and Biopharmaceutics, 137, 218-226. doi: 10.1016/j.ejpb.2019.03.008

Marasini, Nirmal and Kaminskas, Lisa M. (2019). Subunit-based mucosal vaccine delivery systems for pulmonary delivery - Are they feasible?. Drug development and Industrial Pharmacy, 45 (6), 1-13. doi: 10.1080/03639045.2019.1583758

Yu, Sul Hwa, Patra, Malay, Ferrari, Stefano, Ramirez Garcia, Paulina, Veldhuis, Nicholas A., Kaminskas, Lisa M., Graham, Bim, Quinn, John F., Whittaker, Michael R., Gasser, Gilles and Davis, Thomas P. (2018). Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(I) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles. Journal of Materials Chemistry B, 6 (47), 7805-7810. doi: 10.1039/c8tb02464b

Mehta, Dharmini, Leong, Nathania, McLeod, Victoria M., Kelly, Brian D., Pathak, Rashmi, Owen, David J., Porter, Christopher J.H. and Kaminskas, Lisa M. (2018). Reducing dendrimer generation and PEG chain length increases drug release and promotes anti-cancer activity of PEGylated polylysine dendrimers conjugated with doxorubicin via a cathepsin-cleavable peptide linker. Molecular Pharmaceutics, 15 (10) acs.molpharmaceut.8b00581, 4568-4576. doi: 10.1021/acs.molpharmaceut.8b00581

Leong, Nathania J., Mehta, Dharmini, McLeod, Victoria M., Kelly, Brian D., Pathak, Rashmi, Owen, David J., Porter, Christopher J. H. and Kaminskas, Lisa M. (2018). Doxorubicin conjugation and drug linker chemistry alter the intravenous and pulmonary pharmacokinetics of a PEGylated Generation 4 polylysine dendrimer in rats. Journal of Pharmaceutical Sciences, 107 (9), 2509-2513. doi: 10.1016/j.xphs.2018.05.013

Haque, Shadabul, Whittaker, Michael, McIntosh, Michelle P., Pouton, Colin W, Phipps, Simon and Kaminskas, Lisa M. (2018). A comparison of the lung clearance kinetics of Solid lipid nanoparticles and Liposomes by following the 3H-labelled structural lipids after pulmonary delivery in rats. European Journal of Pharmaceutics and Biopharmaceutics , 125, 1-12. doi: 10.1016/j.ejpb.2018.01.001

Yadav, Preeti, McLeod, Victoria M., Nowell, Cameron J., Selby, Laura I., Johnston, Angus P. R., Kaminskas, Lisa M. and Trevaskis, Natalie L. (2018). Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery. Journal of Controlled Release , 272, 17-28. doi: 10.1016/j.jconrel.2017.12.031

Haque, Shadabul, Md, Shadab, Whittaker, Michael and Kaminskas, Lisa M. (2018). The applications of 3D printing in pulmonary drug delivery and treatment of respiratory disorders. Current Pharmaceutical Design, 24 (42), 5072-5080. doi: 10.2174/1381612825666181206123414

Haque, Shadabul, Boyd, Ben J., McIntosh, Michelle P., Pouton, Colin W., Kaminskas, Lisa M. and Whittaker, Michael (2018). Suggested procedures for the reproducible synthesis of poly(d,l-lactide-co-glycolide) nanoparticles using the emulsification solvent diffusion platform. Current Nanoscience, 14 (5), 448-453. doi: 10.2174/1573413714666180313130235

Ryan G.M., McLeod V.M., Mehta D., Kelly B.D., Stanislawski P.C., Owen D.J., Kaminskas L.M. and Porter C.J.H. (2017). Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site. Nanomedicine: Nanotechnology, Biology and Medicine, 13 (8), 2485-2494. doi: 10.1016/j.nano.2017.08.003

Dong, Yao-Da, Tchung, Estefania, Nowell, Cameron, Kaga, Sadik, Leong, Nathania, Mehta, Dharmini, Kaminskas, Lisa M. and Boyd, Ben J. (2017). Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration. Journal of Liposome Research, 29 (1), 1-9. doi: 10.1080/08982104.2017.1391285

Haque, Shadabul, McLeod, Victoria M., Jones, Seth, Fung, Sandy, Whittaker, Michael, McIntosh, Michelle, Pouton, Colin, Owen, David J., Porter, Christopher J. H. and Kaminskas, Lisa M. (2017). Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers. European Journal of Pharmaceutics and Biopharmaceutics, 119, 408-418. doi: 10.1016/j.ejpb.2017.07.005

Kaga, Sadik, Truong, Nghia P., Esser, Lars, Senyschyn, Danielle, Sanyal, Amitav, Sanyal, Rana, Quinn, John F., Davis, Thomas P., Kaminskas, Lisa M. and Whittaker, Michael R. (2017). Influence of size and shape on the biodistribution of nanoparticles prepared by polymerization-induced self-assembly. Biomacromolecules, 18 (12), 3963-3970. doi: 10.1021/acs.biomac.7b00995

Chan, Linda J., Feeney, Orlagh M., Leong, Nathania J., McLeod, Victoria M., Porter, Christopher J.H., Williams, Charlotte C. and Kaminskas, Lisa M. (2017). An evaluation of optimal PEGylation strategies for maximizing the lymphatic exposure and antiviral activity of interferon after subcutaneous administration. Biomacromolecules, 18 (9), 2866-2875. doi: 10.1021/acs.biomac.7b00794

Marasini, Nirmal, Haque, Shadabul and Kaminskas, Lisa M. (2017). Polymer-drug conjugates as inhalable drug delivery systems: A review. Current Opinion in Colloid & Interface Science, 31, 18-29. doi: 10.1016/j.cocis.2017.06.003

Haque, Shadabul, Whittaker, Michael R., McIntosh, Michelle P., Pouton, Colin W. and Kaminskas, Lisa M. (2016). Disposition and safety of inhaled biodegradable nanomedicines: opportunities and challenges. Nanomedicine: Nanotechnology, Biology, and Medicine, 12 (6), 1703-1724. doi: 10.1016/j.nano.2016.03.002

Kuehl, Christopher, Zhang, Ti, Kaminskas, Lisa M., Porter, Christopher J. H., Davies, Neal M., Forrest, Laird and Berkland, Cory (2016). Hyaluronic Acid Molecular Weight Determines Lung Clearance and Biodistribution after Instillation. Molecular Pharmaceutics, 13 (6), 1904-1914. doi: 10.1021/acs.molpharmaceut.6b00069

Chan, Linda J., Ascher, David B., Yadav, Rajbharan, Bulitta, Jürgen B., Williams, Charlotte C., Porter, Christopher J. H., Landersdorfer, Cornelia B. and Kaminskas, Lisa M. (2016). Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab′ Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity. Molecular Pharmaceutics, 13 (4), 1229-1241. doi: 10.1021/acs.molpharmaceut.5b00749

Ryan, Gemma M., Bischof, Robert J., Enkhbaatar, Perenlei, McLeod, Victoria M., Chan, Linda J., Jones, Seth A., Owen, David J., Porter, Christopher J. H. and Kaminskas, Lisa M. (2016). A comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheep. Pharmaceutical Research, 33 (2), 510-525. doi: 10.1007/s11095-015-1806-z

Sou, Tomás, Forbes, Robert T., Gray, Jason, Prankerd, Richard J., Kaminskas, Lisa M., McIntosh, Michelle P. and Morton, David A.V. (2016). Designing a multi-component spray-dried formulation platform for pulmonary delivery of biopharmaceuticals: the use of polyol, disaccharide, polysaccharide and synthetic polymer to modify solid-state properties for glassy stabilisation. Powder Technology, 287, 248-255. doi: 10.1016/j.powtec.2015.10.008

Khor, Song Yang, Hu, Jinming, McLeod, Victoria M., Quinn, John F., Porter, Christopher J. H., Whittaker, Michael R., Kaminskas, Lisa M. and Davis, Thomas P. (2016). The pharmacokinetics and biodistribution of a 64 kDa PolyPEG star polymer after subcutaneous and pulmonary administration to rats. Journal of Pharmaceutical Sciences, 105 (1), 293-300. doi: 10.1016/j.xphs.2015.11.038

Landersdorfer, Cornelia B., Caliph, Suzanne M., Shackleford, David M., Ascher, David B. and Kaminskas, Lisa M. (2015). PEGylated interferon displays differences in plasma clearance and bioavailability between male and female mice and between female immunocompetent C57Bl/6J and athymic nude mice. Journal of Pharmaceutical Sciences, 104 (5), 1848-1855. doi: 10.1002/jps.24412

Khor, Song Yang, Hu, Jinming, McLeod, Victoria M., Quinn, John F., Williamson, Mark, Porter, Christopher J. H., Whittaker, Michael R., Kaminskas, Lisa M. and Davis, Thomas P. (2015). Molecular weight (hydrodynamic volume) dictates the systemic pharmacokinetics and tumour disposition of PolyPEG star polymers. Nanomedicine: Nanotechnology, Biology and Medicine, 11 (8), 2099-2108. doi: 10.1016/j.nano.2015.08.001

Trevaskis, Natalie L., Kaminskas, Lisa M. and Porter, Christopher J. H. (2015). From sewer to saviour-targeting the lymphatic system to promote drug exposure and activity. Nature Reviews Drug Discovery, 14 (11), 781-803. doi: 10.1038/nrd4608

Sou, Tomás, Morton, David A.V., Williamson, Mark, Meeusen, Els N., Kaminskas, Lisa M. and McIntosh, Michelle P. (2015). Spray-dried influenza antigen with trehalose and leucine produces an aerosolizable powder vaccine formulation that induces strong systemic and mucosal immunity after pulmonary administration. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28 (5), 361-371. doi: 10.1089/jamp.2014.1176

Mcleod, Victoria M., Chan, Linda J., Ryan, Gemma M., Porter, Christopher J. H. and Kaminskas, Lisa M. (2015). Optimal PEGylation can improve the exposure of interferon in the lungs following pulmonary administration. Journal of Pharmaceutical Sciences, 104 (4), 1421-1430. doi: 10.1002/jps.24353

Kaminskas, Lisa M., McLeod, Victoria M., Ascher, David B., Ryan, Gemma M., Jones, Seth, Haynes, John M., Trevaskis, Natalie L., Chan, Linda J., Sloan, Erica K., Finnin, Benjamin A., Williamson, Mark, Velkov, Tony, Williams, Elizabeth D., Kelly, Brian D., Owen, David J. and Porter, Christopher J. H. (2015). Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats. Molecular Pharmaceutics, 12 (2), 432-443. doi: 10.1021/mp500531e

Chan, Linda J., Bulitta, Jürgen B., Ascher, David B., Haynes, John Michael, McLeod, Victoria M., Porter, Christopher J. H., Williams, Charlotte C. and Kaminskas, Lisa M. (2015). PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration. Molecular Pharmaceutics, 12 (3), 794-809. doi: 10.1021/mp5006189

Caliph, Suzanne M., Shackleford, David M., Ascher, David B. and Kaminskas, Lisa M. (2014). Practical lessons in murine thoracic lymph duct cannulations: Observations in female and male mice across four different strains that impact on cannulatability. Journal of Pharmaceutical Sciences, 104 (3), 1207-1209. doi: 10.1002/jps.24312

Ryan, Gemma M., Kaminskas, Lisa M. and Porter, Christopher J.H. (2014). Nano-chemotherapeutics: maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers. Journal of Controlled Release, 193, 241-256. doi: 10.1016/j.jconrel.2014.04.051

Kaminskas, Lisa M., McLeod, Victoria M., Ryan, Gemma M., Kelly, Brian D., Haynes, John M., Williamson, Mark, Thienthong, Neeranat, Owen, David J. and Porter, Christopher J. H. (2014). Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy. Journal of Controlled Release, 183 (1), 18-26. doi: 10.1016/j.jconrel.2014.03.012

Dahlberg, Annette M., Kaminskas, Lisa M., Smith, Alanna, Nicolazzo, Joseph A., Porter, Christopher J. H., Bulitta, Jürgen B. and McIntosh, Michelle P. (2014). The lymphatic system plays a major role in the intravenous and subcutaneous pharmacokinetics of trastuzumab in rats. Molecular Pharmaceutics, 11 (2), 496-504. doi: 10.1021/mp400464s

Ryan, Gemma M., Kaminskas, Lisa M., Bulitta, Juergen B., McIntosh, Michelle P., Owen, David J. and Porter, Christopher J. H. (2013). PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin. Journal of Controlled Release, 172 (1), 128-136. doi: 10.1016/j.jconrel.2013.08.004

Sou, Tomás, McIntosh, Michelle P., Kaminskas, Lisa M., Prankerd, Richard J. and Morton, David A. V. (2013). Designing a multicomponent spray-dried formulation platform for pulmonary delivery of biomacromolecules: the effect of polymers on the formation of an amorphous matrix for glassy state stabilization of biomacromolecules. Drying Technology, 31 (13-14), 1451-1458. doi: 10.1080/07373937.2013.788019

Ryan, Gemma M., Kaminskas, Lisa M., Kelly, Brian D., Owen, David J., McIntosh, Michelle P. and Porter, Christopher J. H. (2013). Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent. Molecular Pharmaceutics, 10 (8), 2986-2995. doi: 10.1021/mp400091n

Velkov, Tony, Deris, Zakuan Z., Huang, Johnny X., Azad, Mohammad A. K., Butler, Mark, Sivanesan, Sivashangarie, Kiminskas, Lisa M., Dong, Yao-Da, Boyd, Ben, Baker, Mark A., Cooper, Matthew A., Nation, Roger L. and Li, Jian (2013). Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae. Innate Immunity, 20 (4), 350-363. doi: 10.1177/1753425913493337

Kaminskas, Lisa M., Ascher, David B., McLeod, Victoria M., Herold, Marco J., Le, Caroline P., Sloan, Erica K. and Porter, Christopher J. H. (2013). PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases. Journal of Controlled Release, 168 (2), 200-208. doi: 10.1016/j.jconrel.2013.03.006

Sou, Tomás, Kaminskas, Lisa M., Nguyen, Tri-Hung, Carlberg, Renée, McIntosh, Michelle P. and Morton, David A.V. (2013). The effect of amino acid excipients on morphology and solid-state properties of multi-component spray-dried formulations for pulmonary delivery of biomacromolecules. European Journal of Pharmaceutics and Biopharmaceutics, 83 (2), 234-243. doi: 10.1016/j.ejpb.2012.10.015

Burcham, Philip C., Raso, Albert and Kaminskas, Lisa M. (2012). Chaperone heat shock protein 90 mobilization and hydralazine cytoprotection against acrolein-induced carbonyl stress. Molecular Pharmacology, 82 (5), 876-886. doi: 10.1124/mol.112.078956

Kaminskas, Lisa M., McLeod, Victoria M., Kelly, Brian D., Cullinane, Carleen, Sberna, Gian, Williamson, Mark, Boyd, Ben J., Owen, David J. and Porter, Christopher J. H. (2012). Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models. Molecular Pharmaceutics, 9 (3), 422-432. doi: 10.1021/mp200522d

Kaminskas, Lisa M., McLeod, Victoria M., Porter, Christopher J. H. and Boyd, Ben J. (2012). Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation. Molecular Pharmaceutics, 9 (3), 355-373. doi: 10.1021/mp2005966

Kaminskas, Lisa M., McLeod, Victoria M., Kelly, Brian D., Sberna, Gian, Boyd, Ben J., Williamson, Mark, Owen, David J. and Porter, Christopher J. H. (2012). A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems. Nanomedicine: Nanotechnology, Biology and Medicine, 8 (1), 103-111. doi: 10.1016/j.nano.2011.05.013

Kaminskas, Lisa M., Boyd, Ben J. and Porter, Christopher J.H. (2012). Erratum: Dendrimer pharmacokinetics: The effect of size, structure and surface characteristics on ADME properties (Nanomedicine (2011) 6:6 (1063-1084)). Nanomedicine, 7 (1). doi: 10.2217/nnm.11.173

Sou, Tomas, Orlando, Laurence, McIntosh, Michelle P., Kaminskas, Lisa M. and Morton, David A. V. (2011). Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: a design of experiment approach. International Journal of Pharmaceutics, 421 (2), 220-229. doi: 10.1016/j.ijpharm.2011.09.018

Kaminskas, Lisa M., Mcleod, Victoria M., Porter, Christopher J. H. and Boyd, Ben J. (2011). Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance. Journal of Pharmaceutical Sciences, 100 (11), 5069-5077. doi: 10.1002/jps.22682

Kaminskas, Lisa M. and Porter, Christopher J. H. (2011). Targeting the lymphatics using dendritic polymers (dendrimers). Advanced Drug Delivery Reviews, 63 (10-11), 890-900. doi: 10.1016/j.addr.2011.05.016

Kaminskas, Lisa M., Boyd, Ben J. and Porter, Christopher J. H. (2011). Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties. Nanomedicine, 6 (6), 1063-1084. doi: 10.2217/nnm.11.67

Kaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Sberna, Gian, Owen, David J., Boyd, Ben J. and Porter, Christopher J. H. (2011). Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker. Journal of Controlled Release, 152 (2), 241-248. doi: 10.1016/j.jconrel.2011.02.005

Kaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Sberna, Gian, Boyd, Ben J., Owen, David J. and Porter, Christopher J. H. (2011). Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimers. Molecular Pharmaceutics, 8 (2), 338-349. doi: 10.1021/mp1001872

Sou, Tomas, Meeusen, Els N., de Veer, Michael, Morton, David A. V., Kaminskas, Lisa M. and McIntosh, Michelle P. (2011). New developments in dry powder pulmonary vaccine delivery. Trends in Biotechnology, 29 (4), 191-198. doi: 10.1016/j.tibtech.2010.12.009

Kaminskas, Lisa M., Kota, Jagannath, McLeod, Victoria M., Kelly, Brian D., Karellas, Peter and Porter, Christopher J. H. (2009). PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats. Journal of Controlled Release, 140 (2), 108-116. doi: 10.1016/j.jconrel.2009.08.005

Kaminskas, L. M., Wu, Z., Barlow, N., Krippner, G. Y., Boyd, B. J. and Porter, C. J. H. (2009). Partly-PEGylated poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers. Journal of Pharmaceutical Sciences, 98 (10), 3871-3875. doi: 10.1002/jps.21692

Kaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Boyd, Ben J., Krippner, Guy Y., Williams, Elizabeth D. and Porter, Christopher J. H. (2009). Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-L-lysine dendrimers. Molecular Pharmaceutics, 6 (4), 1190-1204. doi: 10.1021/mp900049a

Kaminskas, Lisa M., Boyd, Ben J., Karellas, Peter, Krippner, Guy Y., Lessene, Romina, Kelly, Brian and Porter, Chrisiopher J. H. (2008). The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of pegylated poly L-lysine dendrimers. Molecular Pharmaceutics, 5 (3), 449-463. doi: 10.1021/mp7001208

Burcham, P. C., Kaminskas, L. M., Tan, D. and Pyke, S. M. (2008). Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury. Mini-Reviews in Medicinal Chemistry, 8 (4), 319-330. doi: 10.2174/138955708783955953

Kaminskas, Lisa M., Boyd, Ben J., Karellas, Peter, Henderson, Scott A., Giannis, Michael P., Krippner, Guy Y. and Porter, Christopher J. H. (2007). Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and disposition. Molecular Pharmaceutics, 4 (6), 949-961. doi: 10.1021/mp070047s

Kaminskas, Lisa M., Pyke, Simon M. and Burcham, Philip C. (2007). Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: targets for cytoprotective hydrazino drugs. Rapid Communications in Mass Spectrometry, 21 (7), 1155-1164. doi: 10.1002/rcm.2945

Boyd, Ben J., Kaminskas, Lisa M., Karellas, Peter, Krippner, Guy, Lessene, Romina and Porter, Christopher J. H. (2006). Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats. Molecular Pharmaceutics, 3 (5), 614-627. doi: 10.1021/mp060032e

Kaminskas, Lisa M., Pyke, Simon M. and Burcham, Philip C. (2005). Differences in lysine adduction by acrolein and methyl vinyl ketone: implications for cytotoxicity in cultured hepatocytes. Chemical Research in Toxicology, 18 (11), 1627-1633. doi: 10.1021/tx0502387

Kaminskas, Lisa M., Pyke, Simon M. and Burcham, Philip C. (2004). Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde. Organic and Biomolecular Chemistry, 2 (18), 2578-2584. doi: 10.1039/b408796h

Kaminskas, Lisa M., Pyke, Simon M. and Burcham, Philip C. (2004). Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice. Journal of Pharmacology and Experimental Therapeutics, 310 (3), 1003-1010. doi: 10.1124/jpet.104.067330

Burcham, Philip C., Fontaine, Frank R., Kaminskas, Lisa M., Petersen, Dennis R. and Pyke, Simon M. (2004). Protein Adduct-Trapping by Hydrazinophthalazine Drugs: Mechanisms of Cytoprotection Against Acrolein-Mediated Toxicity. Molecular Pharmacology, 65 (3), 655-664. doi: 10.1124/mol.65.3.655

Burcham, Philip C., Kaminskas, Lisa M., Fontaine, Frank R., Petersen, Dennis R. and Pyke, Simon M. (2002). Aldehyde-Sequestering Drugs: Tools for Studying Protein Damage by Lipid Peroxidation Products. Toxicology, 181-182, 229-236. doi: 10.1016/S0300-483X(02)00287-1

Kaminskas, Lisa M., Irvine, Rodney J., Callaghan, Paul D., White, Jason M. and Kirkbride, Paul (2002). The contribution of the metabolitep-hydroxyamphetamine to the central actions ofp-methoxyamphetamine. Psychopharmacology, 160 (2), 155-160. doi: 10.1007/s00213-001-0984-z

Gamble, Jennifer R., Drew, Jenny, Trezise, Libby, Underwood, Anne, Parsons, Michelle, Kasminkas, Lisa, Rudge, John, Yancopoulos, George and Vadas, Mathew A. (2000). Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circulation research, 87 (7), 603-607. doi: 10.1161/01.res.87.7.603

Murray, Margaret, Gibbon, Anne, Kaminskas, Lisa, Selby-Pham, Sophie, Williamson, Gary and Bennett, Louise (2023). Fermentation metabolites of 14C-labelled aromatic amino acid, tyrosine, detected in the brain in a pig model. IUNS 22nd International Congress of Nutrition, Tokyo, Japan, 14 - 19 September 2021. Basel, Switzerland: S. Karger.

Surber, M., Kaminskas, L., Landersdorfer, C., Bischof, R., Beck, S., Pham, S., Jain, A., Halvarsson, A., Hug, M. and Montgomery, A. (2019). Pharmacokinetics and Safety of Pirfenidone Following Inhaled Delivery to Sheep: A Viable Approach to Treating Idiopathic Pulmonary Fibrosis. International Conference of the American-Thoracic-Society, Dallas Tx, May 17-22, 2019. NEW YORK: AMER THORACIC SOC. doi: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5422

Associate Professor Lisa Kaminskas

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