Dr Vinod Kumar
Postdoctoral Research Fellow
School of Biomedical Sciences
+61 7 336 52384
Dr Kumar joined the Neuroinflammation laboratory after completing a PhD on the pharmacokinetics of complement C5a receptor antagonists. He currently works on the preclinical development of novel therapeutics for neurodegenerative disease. He has specific analytical expertise and conducts a number of assays aimed at progressing new therapeutics towards clinical trials.
Journal Articles
Kumar, Vinod, Lee, John D., Coulson, Elizabeth J. and Woodruff, Trent M. (2020). A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models. Journal of Neurochemistry jnc.15119 doi: 10.1111/jnc.15119
Han, Felicity Y., Liu, Yun, Kumar, Vinod, Xu, Weizhi, Yang, Guangze, Zhao, Chun-Xia, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581 119291, 119291. doi: 10.1016/j.ijpharm.2020.119291
Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah, Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent, Kent, Stephen, Searles, Debra and Whittaker, Andrew (2020). Low-fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie International Edition, 59 (12) ange.201914119, 4729-4735. doi: 10.1002/anie.201914119
Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah G., Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent M., Kent, Stephen J., Searles, Debra J. and Whittaker, Andrew K. (2020). Low‐fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie, 132 (12), 4759-4765. doi: 10.1002/ange.201914119
Kumar, Vinod, Lee, John D., Clark, Richard J., Noakes, Peter G., Taylor, Stephen M. and Woodruff, Trent M. (2020). Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in mice. ACS Omega, 5 (5) acsomega.9b03735, 2345-2354. doi: 10.1021/acsomega.9b03735
Tan, Sih Min, Ziemann, Mark, Thallas-Bonke, Vicki, Snelson, Matthew, Kumar, Vinod, Laskowski, Adrienne, Nguyen, Tuong-Vi, Huynh, Kevin, Clarke, Michele V., Libianto, Renata, Baker, Scott T., Skene, Alison, Power, David A., MacIsaac, Richard J., Henstridge, Darren C., Wetsel, Rick A., El-Osta, Assam, Meikle, Peter J., Wilson, Scott G., Forbes, Josephine M., Cooper, Mark E., Ekinci, Elif I., Woodruff, Trent M. and Coughlan, Melinda T. (2019). Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility. Diabetes, 69 (1), 83-98. doi: 10.2337/db19-0043
Gordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066
Kumar, Vinod, Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2018). Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Scientific Reports, 8 (1) 8101, 8101. doi: 10.1038/s41598-018-26387-4
Michailidou, Iliana, Jongejan, Aldo, Vreijling, Jeroen P., Georgakopoulou, Theodosia, de Wissel, Marit B., Wolterman, Ruud A., Ruizendaal, Patrick, Klar-Mohamad, Ngaisah, Grootemaat, Anita E., Picavet, Daisy I., Kumar, Vinod, van Kooten, Cees, Woodruff, Trent M., Morgan, B. Paul, van der Wel, Nicole N., Ramaglia, Valeria, Fluiter, Kees and Baas, Frank (2018). Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis. Acta Neuropathologica Communications, 6 (1) 36, 36. doi: 10.1186/s40478-018-0536-y
Lee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730
Denny, Kerina J., Kelly, Christina F., Kumar, Vinod, Witham, Katey L., Cabrera, Robert M., Fennell, Richard H., Taylor, Stephen M., Jeanes, Angela and Woodruff, Trent M. (2016). Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Research Part A: Clinical and Molecular Teratology, 106 (3), 201-207. doi: 10.1002/bdra.23483
Mantovani, Susanna, Gordon, Richard, Li, Rui, Christie, Daniel C., Kumar, Vinod and Woodruff, Trent M. (2016). Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice. Human Molecular Genetics, 25 (9) ddw050, 1780-1791. doi: 10.1093/hmg/ddw050
Bryant, Katherine J., Bidgood, Matthew J., Lei, Pei-Wen, Taberner, Megan, Salom, Caroline, Kumar, Vinod, Lee, Lawrence, Church, W. Bret, Courtenay, Brett, Smart, Brian P., Gelb, Michael H., Cahill, Michael A., Graham, Garry G., McNeil, H. Patrick and Scott, Kieran F. (2011). A Bifunctional Role for Group IIA Secreted Phospholipase A(2) in Human Rheumatoid Fibroblast-like Synoviocyte Arachidonic Acid Metabolism. Journal of Biological Chemistry, 286 (4), 2492-2503. doi: 10.1074/jbc.M110.123927
Conference Papers
Gordon, Richard, Albornoz, Eduardo A., Kumar, Vinod, Zhou, Kiane, Garin-Michaud, Ashoka, Mantavani, Susanna, Kanthasamy, Anumantha G. and Woodruff, Trent M. (2016). Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.146
Kumar, Vinod, Lee, John, Noakes, Peter and Woodruff, Trent (2015). Blood brain barrier impairment alters the pharmacokinetic properties of the complement C5aR1 antagonist PMX205 in mouse models of neurodegeneration. 8th International Conference on Complement Therapeutics, Chania, Crete, Greece, 1-6 January 2015.
Mantovani, S., Li, R., Gordon, R., Kumar, V., Taylor, S. and Woodruff, T. M. (2013). Behavioural and pathological phenotyping of the C57BL/6J BACHD transgenic mouse model of Huntington’s disease. World Congress on Huntington’s disease, Rio de Janeiro, Brazil, 15-18 September 2013. Amsterdam, Netherlands: I O S Press.
Thesis
Kumar, Vinod (2017). Pharmacokinetics of complement C5a receptor 1 antagonists in mice, and their role in protecting CNS barriers during neurodegeneration. PhD Thesis, Medicine Faculty, The University of Queensland. doi: 10.14264/uql.2017.471