Dr Vinod Kumar
Adjunct Senior Research Fellow
School of Biomedical Sciences
Dr Kumar joined the Neuroinflammation laboratory after completing a PhD on the pharmacokinetics of complement C5a receptor antagonists. He currently works on the preclinical development of novel therapeutics for neurodegenerative disease. He has specific analytical expertise and conducts a number of assays aimed at progressing new therapeutics towards clinical trials.
Journal Articles
Cui, Cedric S., Lerskiatiphanich, Titaya, Li, Xaria X., Giri, Rabina, Liu, Ning, Kumar, Vinod, Whittaker, Andrew K., Han, Felicity Y., Clark, Richard J., Begun, Jakob, Lee, John D. and Woodruff, Trent M. (2025). Colon‐targeted complement C5a1 receptor inhibition using pH‐sensitive nanoparticles ameliorates experimental colitis. British Journal of Pharmacology, 182 (16), 3852-3869. doi: 10.1111/bph.70056
Snelson, Matthew, Deliyanti, Devy, Tan, Sih Min, Drake, Anna M., de Pasquale, Cassandra, Kumar, Vinod, Woodruff, Trent M., Wilkinson-Berka, Jennifer L. and Coughlan, Melinda T. (2024). Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment. Nutrition and Diabetes, 14 (1) 46, 1-9. doi: 10.1038/s41387-024-00305-2
Pang, Huiwen, Qu, Zhi, Kumar, Vinod, Wang, Yinuo, Wu, Youzhi, Lin, Min‐Hsuan, Harrich, David and Han, Felicity Y. (2024). Novel Delivery Systems for Oral Administration of Enfuvirtide: New Treatment Options for HIV/AIDS. Advanced Therapeutics, 7 (8) 2300439, 1-9. doi: 10.1002/adtp.202300439
Khan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Irwin, Adam (RSG member), Phillips, Natalie (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G., Woodruff, Trent M. and Bialasiewicz, Seweryn (RSG member) (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768
Albornoz, Eduardo A., Gordon, Richard, Kumar, Vinod, Robertson, Avril A. B., Schroder, Kate and Woodruff, Trent M. (2023). Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”. Science Translational Medicine, 15 (696) adh0604, 1-4. doi: 10.1126/scitranslmed.adh0604
Sikder, Md. Al Amin, Rashid, Ridwan B., Ahmed, Tufael, Sebina, Ismail, Howard, Daniel R., Ullah, Md. Ashik, Rahman, Muhammed Mahfuzur, Lynch, Jason P., Curren, Bodie, Werder, Rhiannon B., Simpson, Jennifer, Bissell, Alec, Morrison, Mark, Walpole, Carina, Radford, Kristen J., Kumar, Vinod, Woodruff, Trent M., Ying, Tan Hui, Ali, Ayesha, Kaiko, Gerard E., Upham, John W., Hoelzle, Robert D., Cuív, Páraic Ó., Holt, Patrick G., Dennis, Paul G. and Phipps, Simon (2023). Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Immunity, 56 (5), 1098-1114.e10. doi: 10.1016/j.immuni.2023.03.002
Neal, Elliott, Kumar, Vinod, Borges, Karin and Cuffe, James S.M. (2023). Vitamin B12 deficiency induces glucose intolerance, delays peak insulin levels and promotes ketogenesis in female rats. The Journal of Endocrinology, 256 (2) e220158, 1-16. doi: 10.1530/joe-22-0158
Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y. (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022). Advanced Therapeutics, 5 (12) 2270030, 1-1. doi: 10.1002/adtp.202270030
Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics, 5 (12) 2200109, 2200109. doi: 10.1002/adtp.202200109
Steane, Sarah E., Kumar, Vinod, Cuffe, James S. M., Moritz, Karen M. and Akison, Lisa K. (2022). Prenatal choline supplementation alters one carbon metabolites in a rat model of periconceptional alcohol exposure. Nutrients, 14 (9) 1874, 1874. doi: 10.3390/nu14091874
Murray, Margaret, Coughlan, Melinda T., Gibbon, Anne, Kumar, Vinod, Marques, Francine Z., Selby-Pham, Sophie, Snelson, Matthew, Tsyganov, Kirill, Williamson, Gary, Woodruff, Trent M., Wu, Tong and Bennett, Louise E. (2022). Reduced Growth, Altered Gut Microbiome and Metabolite Profile, and Increased Chronic Kidney Disease Risk in Young Pigs Consuming a Diet Containing Highly Resistant Protein. Frontiers in Nutrition, 9 816749, 816749. doi: 10.3389/fnut.2022.816749
Cui, Cedric S., Kumar, Vinod, Gorman, Declan M., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2021). In vivo pharmacodynamic method to assess complement C5a receptor antagonist efficacy. ACS Pharmacology and Translational Science, 5 (1) acsptsci.1c00227, 41-51. doi: 10.1021/acsptsci.1c00227
Xu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3
Han, Felicity Y., Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria, Jiang, Xingyu, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2021). Optimisation of a microfluidic method for the delivery of a small peptide. Pharmaceutics, 13 (9) 1505, 1505. doi: 10.3390/pharmaceutics13091505
McDonald, Tanya S., Kumar, Vinod, Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2021). Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanism. The FASEB Journal, 35 (7) e21707, e21707. doi: 10.1096/fj.202002450r
Li, Xaria X., Kumar, Vinod, Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2021). The “C3aR Antagonist” SB290157 is a partial C5aR2 agonist. Frontiers in Pharmacology, 11 591398, 591398. doi: 10.3389/fphar.2020.591398
Kumar, Vinod, Lee, John D., Coulson, Elizabeth J. and Woodruff, Trent M. (2020). A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models. Journal of Neurochemistry, 158 (3) jnc.15119, 807-817. doi: 10.1111/jnc.15119
Han, Felicity Y., Liu, Yun, Kumar, Vinod, Xu, Weizhi, Yang, Guangze, Zhao, Chun-Xia, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581 119291, 119291. doi: 10.1016/j.ijpharm.2020.119291
Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah, Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent, Kent, Stephen, Searles, Debra and Whittaker, Andrew (2020). Low-fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie International Edition, 59 (12), 4729-4735. doi: 10.1002/anie.201914119
Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah G., Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent M., Kent, Stephen J., Searles, Debra J. and Whittaker, Andrew K. (2020). Low‐fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie, 132 (12), 4759-4765. doi: 10.1002/ange.201914119
Kumar, Vinod, Lee, John D., Clark, Richard J., Noakes, Peter G., Taylor, Stephen M. and Woodruff, Trent M. (2020). Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in mice. ACS Omega, 5 (5) acsomega.9b03735, 2345-2354. doi: 10.1021/acsomega.9b03735
Tan, Sih Min, Ziemann, Mark, Thallas-Bonke, Vicki, Snelson, Matthew, Kumar, Vinod, Laskowski, Adrienne, Nguyen, Tuong-Vi, Huynh, Kevin, Clarke, Michele V., Libianto, Renata, Baker, Scott T., Skene, Alison, Power, David A., MacIsaac, Richard J., Henstridge, Darren C., Wetsel, Rick A., El-Osta, Assam, Meikle, Peter J., Wilson, Scott G., Forbes, Josephine M., Cooper, Mark E., Ekinci, Elif I., Woodruff, Trent M. and Coughlan, Melinda T. (2019). Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility. Diabetes, 69 (1), 83-98. doi: 10.2337/db19-0043
Gordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066
Kumar, Vinod, Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2018). Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Scientific Reports, 8 (1) 8101, 8101. doi: 10.1038/s41598-018-26387-4
Michailidou, Iliana, Jongejan, Aldo, Vreijling, Jeroen P., Georgakopoulou, Theodosia, de Wissel, Marit B., Wolterman, Ruud A., Ruizendaal, Patrick, Klar-Mohamad, Ngaisah, Grootemaat, Anita E., Picavet, Daisy I., Kumar, Vinod, van Kooten, Cees, Woodruff, Trent M., Morgan, B. Paul, van der Wel, Nicole N., Ramaglia, Valeria, Fluiter, Kees and Baas, Frank (2018). Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis. Acta Neuropathologica Communications, 6 (1) 36, 36. doi: 10.1186/s40478-018-0536-y
Lee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730
Denny, Kerina J., Kelly, Christina F., Kumar, Vinod, Witham, Katey L., Cabrera, Robert M., Fennell, Richard H., Taylor, Stephen M., Jeanes, Angela and Woodruff, Trent M. (2016). Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Research Part A: Clinical and Molecular Teratology, 106 (3), 201-207. doi: 10.1002/bdra.23483
Mantovani, Susanna, Gordon, Richard, Li, Rui, Christie, Daniel C., Kumar, Vinod and Woodruff, Trent M. (2016). Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice. Human Molecular Genetics, 25 (9) ddw050, 1780-1791. doi: 10.1093/hmg/ddw050
Bryant, Katherine J., Bidgood, Matthew J., Lei, Pei-Wen, Taberner, Megan, Salom, Caroline, Kumar, Vinod, Lee, Lawrence, Church, W. Bret, Courtenay, Brett, Smart, Brian P., Gelb, Michael H., Cahill, Michael A., Graham, Garry G., McNeil, H. Patrick and Scott, Kieran F. (2011). A Bifunctional Role for Group IIA Secreted Phospholipase A(2) in Human Rheumatoid Fibroblast-like Synoviocyte Arachidonic Acid Metabolism. Journal of Biological Chemistry, 286 (4), 2492-2503. doi: 10.1074/jbc.M110.123927
Conference Papers
Snelson, M., Tan, S. M., Kumar, V., Woodruff, T. and Coughlan, M. T. (2023). Dietary resistant starch alters gut microbiota, microbially produced metabolites and albuminuria in diabetic mice. 46th Annual Scientific Meeting of the Nutrition Society of Australia, Perth, WA, Australia, 29 November – 2 December 2022. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/s0029665123001921
Deerain, Nick, Kumar, Vinod, Clark, Richard and Woodruff, Trent (2022). Identification of potent small peptides targeting human C3a receptor. ICW – 2021 Virtual Workshop of the International Complement Society (ICS), Virtual, 7-10 December 2021. Oxford, United Kingdom: Elsevier.
Cui, Cedric, Kumar, Vinod, Gorman, Declan, Clark, Richard, Lee, John and Woodruff, Trent (2021). An in-vivo pharmacodynamic method to investigate complement C5a receptor antagonists. ICW – 2021 Virtual Workshop of the International Complement Society (ICS), Virtual, 7-10 December 2021. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.molimm.2021.11.020
Tran, Shirley, Woodruff, Trent, Kumar, Vinod, Smith, A. Ian, Rajapakse, Niwanthi and Kuruppu, Sanjaya (2021). Stimulating the Activity of NEP and ACE2: A Unique Approach to Prevent Dementia. Experimental Biology Meeting EB 2021, Online, 27–30 April 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.2021.35.s1.01628
Gordon, Richard, Albornoz, Eduardo A., Kumar, Vinod, Zhou, Kiane, Garin-Michaud, Ashoka, Mantavani, Susanna, Kanthasamy, Anumantha G. and Woodruff, Trent M. (2016). Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.146
Kumar, Vinod, Lee, John, Noakes, Peter and Woodruff, Trent (2015). Blood brain barrier impairment alters the pharmacokinetic properties of the complement C5aR1 antagonist PMX205 in mouse models of neurodegeneration. 8th International Conference on Complement Therapeutics, Chania, Crete, Greece, 1-6 January 2015.
Mantovani, S., Li, R., Gordon, R., Kumar, V., Taylor, S. and Woodruff, T. M. (2013). Behavioural and pathological phenotyping of the C57BL/6J BACHD transgenic mouse model of Huntington’s disease. World Congress on Huntington’s disease, Rio de Janeiro, Brazil, 15-18 September 2013. Amsterdam, Netherlands: I O S Press.
Thesis
Kumar, Vinod (2017). Pharmacokinetics of complement C5a receptor 1 antagonists in mice, and their role in protecting CNS barriers during neurodegeneration. PhD Thesis, Medicine Faculty, The University of Queensland. doi: 10.14264/uql.2017.471