Professor Richard Lewis

Hasan, Md. Mahadhi, Adams, David J. and Lewis, Richard J. (2022). Pharmacology and structure-function of venom peptide inhibitors of N-type (Cav2.2) calcium channels. Voltage-gated calcium channels. (pp. 675-685) edited by Gerald Werner Zamponi and Norbert Weiss. Cham, Switzerland: Springer . doi: 10.1007/978-3-031-08881-0_26

Inserra, Marco, Lavrukhina, Yelena, Jones, Alun, Lewis, Richard J. and Vetter, Irina (2017). Ciguatoxin detection methods and high-throughput assays. Analysis of food toxins and toxicants. (pp. 469-487) edited by Yiu-Chung Wong and Richard J. Lewis. Oxford, United Kingdom: Wiley Blackwell. doi: 10.1002/9781118992685.ch15

Lewis, Richard J. and Vetter, Irina (2016). Ciguatoxin and ciguatera. Marine and freshwater toxins. (pp. 71-92) edited by P. Gopalakrishnakone, Vidal Haddad Jr., Aurelia Tubaro, Euikyung Kim and William R. Kem. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-007-6419-4_13

Dutertre, Sebastien, Griffin, John and Lewis, Richard J. (2016). Phyla Molluska: the venom apparatus of cone snails. Marine and freshwater toxins. (pp. 327-340) edited by P. Gopalakrishnakone, Vidal Haddad Jr., Aurelia Tubaro, Euikyung Kim and William R. Kem. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-007-6419-4_8

Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. Ion channel drug discovery. (pp. 297-313) edited by Brian Cox and Martin Gosling. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849735087-00297

Dutertre, Sebastien, Undheim, Eivind, Pineda, Sandy S., Jin, Ai-Hua (Jean), Lavergne, Vincent, Fry, Bryan G., Lewis, Richard J., Alewood, Paul F. and King, Glenn F. (2015). Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches. Venoms to Drugs. (pp. 80-96) edited by King, Glenn F. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00080

Lewis, Richard J. (2015). Case Study 1: Development of the Analgesic Drugs Prialt (R) and Xen2174 from Cone Snail Venoms. Venoms to drugs: venom as a source for the development of human therapeutics. (pp. 245-254) edited by Glenn F. King. Cambridge, United States: RSC. doi: 10.1039/9781849737876-00245

Lavergne, Vincent, King, Glenn F., Lewis, Richard J. and Alewood, Paul F. (2014). Peptide therapeutics from venomous creatures. Pain therapeutics: current and future treatment paradigms. (pp. 217-246) edited by Charlotte Allerton. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737715-00217

Vetter, Irina, Zimmermann, Katharina and Lewis, Richard J. (2014). Ciguatera toxins: pharmacology, toxicology and detection. Seafood and freshwater toxins: pharmacology, physiology, and detection. (pp. 925-950) edited by Luis M. Botana. Boca Raton, FL, United States: CRC Press. doi: 10.1201/b16662-32

Vetter, I. and Lewis, R. J. (2014). Toxicology of ciguatoxins. Toxins and biologically active compounds from microalgae: Volume 2: biological effects and risk management. (pp. xx-xx) Boca Raton, FL, United States: CRC Press. doi: 10.1201/b16806-17

Amade, Philippe, Mehiri, Mohamed and Lewis, Richard J. (2014). Outstanding marine biotoxins: STX, TTX, and CTX. Outstanding marine molecules: chemistry, biology, analysis. (pp. 23-44) edited by Stéphane La Barre and Jean-Michel Kornprobst. Weinheim, Germany: Wiley Blackwell. doi: 10.1002/9783527681501.ch02

Holmes, Michael J., Brust, Andreas and Lewis, Richard J. (2014). Dinoflagellate Toxins: An Overview. Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection. (pp. 3-38) CRC Press. doi: 10.1201/b16662-1

Dutertre, Sebastien and Lewis, Richard J. (2013). Cone snail biology, bioprospecting and conservation. Snails: biology, ecology and conservation. (pp. 85-104) edited by Emil M. Hämäläinen and Sofia Järvinen. New York, NY, United States: Nova Science Publishers.

Wingerd, Joshua S., Vetter, Irina and Lewis, Richard J. (2012). Voltage-gated sodium channels as therapeutic targets.. Therapeutic targets: Modulation, Inhibition and Activation.. (pp. 63-122) edited by Luis M. Botana and Mabel Loza. Hoboken NJ, United States: John Wiley and Sons.

Vetter, Irina and Lewis, Richard J. (2011). Natural product ligands of TRP channels. Transient receptor potential channels. (pp. 41-85) edited by Md. Shahidul Islam. New York, United States: Springer. doi: 10.1007/978-94-007-0265-3_3

Lewis, R. J. (2009). Conotoxins: molecular and therapeutic targets. Marine toxins as research tools (Progress in Molecular and Subcellular Biology). (pp. 45-66) edited by N. Fusetani. Berlin: Springer Verlag.

Schroeder, C. I., Lewis, R. J. and Adams, D. J. (2005). Block of voltage-gated calcium channels by peptide toxins. Voltage-Gated Calcium Channels. (pp. 294-308) edited by Gerald W. Zamponi. New York, U.S.A.: Springer US. doi: 10.1007/0-387-27526-6_19

Lewis, R. J. (2003). Detection of toxins associated with cigutera fish poisoning. Manual on Harmful Marine Microalgae. (pp. 267-277) edited by Hallegraeff, G M; Anderson, D M; Cembella and A D. Landais, France: UNESCO Publishing.

Holmes, M.J. and Lewis, R. J. (2002). Toxin-producting dinoflagellates. Perspectives in Molecular Toxinology. (pp. 39-65) edited by Andre Menez. England: John Wiley & sons Ltd.

Fenner, P. and Lewis, R. J. (2001). Ciguatera (fish poisoning). Channelopathies of the nervous sytstem. (pp. 295-307) edited by Michael Rose and Robert C. Griggs. USA: Butterworth Heinemann.

Lewis, Richard J., Molgo, Jordi and Adams, David J. (2000). Ciguatera toxins: Pharmacology of toxins involved in Ciguatera and related fish poisonings. Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection. (pp. 419-447) edited by Luis M. Botana. New York: Marcel Dekker Inc..

Dongol, Yashad, Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2023). Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes. Frontiers in Pharmacology, 14 1277143, 1-13. doi: 10.3389/fphar.2023.1277143

Muratspahić, Edin, White, Andrew M., Ciotu, Cosmin I., Hochrainer, Nadine, Tomašević, Nataša, Koehbach, Johannes, Lewis, Richard J., Spetea, Mariana, Fischer, Michael J. M., Craik, David J. and Gruber, Christian W. (2023). Development of a selective peptide κ-opioid receptor antagonist by late-stage functionalization with cysteine staples. Journal of Medicinal Chemistry, 66 (17), 11843-11854. doi: 10.1021/acs.jmedchem.3c00426

Pottier, Ivannah, Lewis, Richard J. and Vernoux, Jean-Paul (2023). Ciguatera fish poisoning in the Caribbean Sea and Atlantic Ocean: reconciling the multiplicity of ciguatoxins and analytical chemistry approach for public health safety. Toxins, 15 (7) 453, 1-40. doi: 10.3390/toxins15070453

Rogalski, Aymeric, Himaya, S. W. A. and Lewis, Richard J. (2023). Coordinated adaptations define the ontogenetic shift from worm-to fish-hunting in a venomous cone snail. Nature Communications, 14 (1) 3287, 1-11. doi: 10.1038/s41467-023-38924-5

Grundy, Luke, Tay, Cindy, Christie, Stewart, Harrington, Andrea M., Castro, Joel, Cardoso, Fernanda C., Lewis, Richard J., Zagorodnyuk, Vladimir and Brierley, Stuart M. (2023). The T type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli. Pain, 164 (5), 1012-1026. doi: 10.1097/j.pain.0000000000002795

Ho, Thao NT, Abraham, Nikita and Lewis, Richard J. (2023). Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors. Frontiers in Pharmacology, 14 1170514, 1170514. doi: 10.3389/fphar.2023.1170514

Holmes, Michael J. and Lewis, Richard J. (2023). Model of the origin of a ciguatoxic grouper (Plectropomus leopardus). Toxins, 15 (3) 230, 1-20. doi: 10.3390/toxins15030230

Begnini, Fabio, Geschwindner, Stefan, Johansson, Patrik, Wissler, Lisa, Lewis, Richard J., Danelius, Emma, Luttens, Andreas, Matricon, Pierre, Carlsson, Jens, Lenders, Stijn, Koenig, Beate, Friedel, Anna, Sjoe, Peter, Schiesser, Stefan and Kihlberg, Jan (2023). "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction" (vol 65, pg 2204, 2022). Journal of Medicinal Chemistry, 66 (3), 2204-2204. doi: 10.1021/acs.jmedchem.3c00037

Holmes, Michael J. and Lewis, Richard J. (2022). Bimodal cell size and fusing cells observed in a clonal culture of the ciguatoxin-producing benthic dinoflagellate Gambierdiscus (WC1/1). Toxins, 14 (11) 767, 1-8. doi: 10.3390/toxins14110767

Cardoso, Fernanda C., Pineda, Sandy S., Herzig, Volker, Sunagar, Kartik, Shaikh, Naeem Yusuf, Jin, Ai-Hua, King, Glenn F., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2022). The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders. International Journal of Molecular Sciences, 23 (21) 13077, 13077. doi: 10.3390/ijms232113077

Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2022). Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors. RSC Medicinal Chemistry, 13 (11), 1410-1419. doi: 10.1039/d2md00188h

Holmes, Michael J. and Lewis, Richard J. (2022). Origin of ciguateric fish: quantitative modelling of the flow of ciguatoxin through a marine food chain. Toxins, 14 (8) 534, 1-11. doi: 10.3390/toxins14080534

Wang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert and Lewis, Richard (2022). Diindolylmethane derivatives: new selective blockers for T-type calcium channels. Membranes, 12 (8) 749, 1-13. doi: 10.3390/membranes12080749

Mattei, César, Tricoire-Leignel, Hélène, Legros, Christian, Lewis, Richard J. and Molgó, Jordi (2022). Editorial: Pharmacological Aspects of Ligand-Gated Ion Channels as Targets of Natural and Synthetic Agents. Frontiers in Neuroscience, 16 895299, 895299. doi: 10.3389/fnins.2022.895299

Wilhelm, Patrick, Luna-Ramirez, Karen, Chin, Yanni K.-Y., Dekan, Zoltan, Abraham, Nikita, Tae, Han-Shen, Chow, Chun Yuen, Eagles, David A., King, Glenn F., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2022). Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor. ACS Chemical Neuroscience, 13 (8), 1245-1250. doi: 10.1021/acschemneuro.1c00857

Prashanth, Jutty Rajan, Dutertre, Sebastien, Rai, Subash Kumar and Lewis, Richard J. (2022). Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous Conus distans. Toxins, 14 (3) 226, 226. doi: 10.3390/toxins14030226

Himaya, S. W. A., Arkhipov, Alexander, Yum, Wai Ying and Lewis, Richard J. (2022). Comparative venomics of C. flavidus and C. frigidus and closely related vermivorous cone snails. Marine Drugs, 20 (3) 209, 209. doi: 10.3390/md20030209

Begnini, Fabio, Geschwindner, Stefan, Johansson, Patrik, Wissler, Lisa, Lewis, Richard J., Danelius, Emma, Luttens, Andreas, Matricon, Pierre, Carlsson, Jens, Lenders, Stijn, Konig, Beate, Friedel, Anna, Sjoe, Peter, Schiesser, Stefan and Kihlberg, Jan (2022). Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction. Journal of Medicinal Chemistry, 65 (4), 3473-3517. doi: 10.1021/acs.jmedchem.1c01975

Cardoso, Fernanda C., Schmit, Matthieu, Kuiper, Michael J., Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2022). Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain. RSC Medicinal Chemistry, 13 (2), 183-195. doi: 10.1039/d1md00331c

Dongol, Yashad, Choi, Phil M., Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Voltage-gated sodium channel modulation by a new spider toxin Ssp1a isolated from an Australian theraphosid. Frontiers in Pharmacology, 12 795455, 795455. doi: 10.3389/fphar.2021.795455

Ho, Thao N.T., Abraham, Nikita and Lewis, Richard J. (2021). Unique pharmacological properties of α-Conotoxin OmIA at α7 nAChRs. Frontiers in Pharmacology, 12 803397, 803397. doi: 10.3389/fphar.2021.803397

Himaya, S. W.A., Jin, Ai-Hua, Hamilton, Brett, Rai, Subash K., Alewood, Paul and Lewis, Richard J. (2021). Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus. Scientific Reports, 11 (1) 13282, 13282. doi: 10.1038/s41598-021-91919-4

Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2021). Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA. Scientific Reports, 11 (1) 21928, 21928. doi: 10.1038/s41598-021-01277-4

Hu, Huiyu, Mawlawi, Saja, Zhao, Tianjiao, Jami, Sina, Deuis, Jennifer R., Vetter, Irina, Lewis, Richard J. and Cardoso, Fernanda C. (2021). Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo. Frontiers in Molecular Biosciences, 8 742457, 742457. doi: 10.3389/fmolb.2021.742457

Holmes, Michael J., Venables, Bill and Lewis, Richard J. (2021). Critical review and conceptual and quantitative models for the transfer and depuration of ciguatoxins in fishes. Toxins, 13 (8) 515, 1-57. doi: 10.3390/toxins13080515

Pierre, Ophélie, Fouchard, Maxime, Le Goux, Nelig, Buscaglia, Paul, Leschiera, Raphaël, Lewis, Richard J., Mignen, Olivier, Fluhr, Joachim W., Misery, Laurent and Le Garrec, Raphaële (2021). Pacific-ciguatoxin-2 and brevetoxin-1 induce the sensitization of sensory receptors mediating pain and pruritus in sensory neurons. Marine Drugs, 19 (7) 387, 1-19. doi: 10.3390/md19070387

Hasan, Md. Mahadhi, Ragnarsson, Lotten, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain. PLOS ONE, 16 (3) e0243645, e0243645. doi: 10.1371/journal.pone.0243645

Hasan, Md. Mahadhi, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous ω-conotoxins alleviate mechanical pain in rodent models of acute peripheral neuropathy. Marine Drugs, 19 (2) 106, 1-15. doi: 10.3390/md19020106

Cardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M. and Lewis, Richard J. (2021). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162 (2), 569-581. doi: 10.1097/j.pain.0000000000002041

Armstrong, David A., Jin, Ai-Hua, Braga Emidio, Nayara, Lewis, Richard J., Alewood, Paul F. and Rosengren, K. Johan (2021). Chemical synthesis and NMR solution structure of conotoxin GXIA from Conus geographus. Marine Drugs, 19 (2) 60, 1-14. doi: 10.3390/md19020060

Ho, Thao N. T., Lee, Han Siean, Swaminathan, Shilpa, Goodwin, Lewis, Rai, Nishant, Ushay, Brianna, Lewis, Richard J., Rosengren, K. Johan and Conibear, Anne C. (2021). Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Medicinal Chemistry, 12 (9), 1574-1584. doi: 10.1039/d1md00182e

Nevin, S. T., Lawrence, N., Nicke, A., Lewis, R. J. and Adams, D. J. (2021). Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits. Channels, 15 (1), 79-93. doi: 10.1080/19336950.2020.1860399

Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2020). Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins. Frontiers in Neuroscience, 14 609005, 1-23. doi: 10.3389/fnins.2020.609005

McMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina and Schroeder, Christina I. (2020). Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor. Biomedicines, 8 (10) 391, 1-15. doi: 10.3390/biomedicines8100391

Herzig, Volker, Sunagar, Kartik, Wilson, David T. R., Pineda, Sandy S., Israel, Mathilde R., Dutertre, Sebastien, McFarland, Brianna Sollod, Undheim, Eivind A. B., Hodgson, Wayne C., Alewood, Paul F., Lewis, Richard J., Bosmans, Frank, Vetter, Irina, King, Glenn F. and Fry, Bryan G. (2020). Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences, 117 (40), 24920-24928. doi: 10.1073/pnas.2004516117

Cardoso, Fernanda C., Marliac, Marie-Adeline, Geoffroy, Chloe, Schmit, Matthieu, Bispat, Anjie, Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2020). The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic and Medicinal Chemistry, 28 (18) 115655, 115655. doi: 10.1016/j.bmc.2020.115655

L’Herondelle, Killian, Pierre, Ophelie, Fouyet, Sophie, Leschiera, Raphael, Le Gall-Ianotto, Christelle, Philippe, Reginald, Buscaglia, Paul, Mignen, Olivier, Talagas, Matthieu, Lewis, Richard J., Michel, Laurence, Misery, Laurent and Le Garrec, Raphaele (2020). PAR2, keratinocytes, and cathepsin S mediate the sensory effects of ciguatoxins responsible for ciguatera poisoning. Journal of Investigative Dermatology, 141 (3), 648-658.e3. doi: 10.1016/j.jid.2020.07.020

Wang, Dan, Himaya, S.W.A., Giacomotto, Jean, Hasan, Md. Mahadhi, Cardoso, Fernanda C., Ragnarsson, Lotten and Lewis, Richard J. (2020). Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator. Marine Drugs, 18 (7) 343, 1-13. doi: 10.3390/md18070343

Mohan, Madhan Kumar, Abraham, Nikita, Rajesh, R. P., Jayaseelan, Benjamin Franklin, Ragnarsson, Lotten, Lewis, Richard J. and Sarma, Siddhartha P. (2020). Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 295 (20), 7096-7112. doi: 10.1074/jbc.RA119.012098

Kuo, Andy, Magiera, Julia, Rethwan, Nursyazwani, Andersson, Åsa, Leen Lam, Ai, Wyse, Bruce, Meutermans, Wim, Lewis, Richard and Smith, Maree (2020). In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. European Journal of Pharmacology, 872 172947, 172947. doi: 10.1016/j.ejphar.2020.172947

Giribaldi, Julien, Ragnarsson, Lotten, Pujante, Tom, Enjalbal, Christine, Wilson, David, Daly, Norelle L., Lewis, Richard J. and Dutertre, Sebastien (2020). Synthesis, pharmacological and structural characterization of novel conopressins from Conus miliaris. Marine Drugs, 18 (3) md18030150, 150. doi: 10.3390/md18030150

Jha, Prerna, Ragnarsson, Lotten and Lewis, Richard J. (2020). Structure-function of the high affinity substrate binding site (S1) of human norepinephrine transporter. Frontiers in Pharmacology, 11 217, 217. doi: 10.3389/fphar.2020.00217

Scheib, Holger, Nekaris, K. Anne-Isola, Rode-Margono, Johanna, Ragnarsson, Lotten, Baumann, Kate, Dobson, James S., Wirdateti, Wirdateti, Nouwens, Amanda, Nijman, Vincent, Martelli, Paolo, Ma, Rui, Lewis, Richard J., Kwok, Hang Fai and Fry, Bryan Grieg (2020). The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein. Toxins, 12 (2) toxins12020086, 86. doi: 10.3390/toxins12020086

Rupasinghe, Darshani B., Herzig, Volker, Vetter, Irina, Dekan, Zoltan, Gilchrist, John, Bosmans, Frank, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2020). Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochemical Pharmacology, 181 114080, 114080. doi: 10.1016/j.bcp.2020.114080

Himaya, S.W.A., Rai, Subash K., Pamfili, Giulia, Jin, Ai-Hua, Alewood, Paul F. and Lewis, Richard J. (2020). Venomic interrogation reveals the complexity of Conus striolatus venom. Australian Journal of Chemistry, 73 (4), 357-365. doi: 10.1071/ch19588

Booth, Simon and Lewis, Richard J. (2019). Structural basis for the coordination of cell division with the synthesis of the bacterial cell envelope. Protein Science, 28 (12), 2042-2054. doi: 10.1002/pro.3722

Dutt, Mriga, Giacomotto, Jean, Ragnarsson, Lotten, Andersson, Åsa, Brust, Andreas, Dekan, Zoltan, Alewood, Paul F. and Lewis, Richard J. (2019). The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports, 9 (1) 17841, 17841. doi: 10.1038/s41598-019-54186-y

Dongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathways. Toxins, 11 (11) 10.3390/toxins11110626, 626. doi: 10.3390/toxins11110626

Jin, Ai-Hua, Muttenthaler, Markus, Dutertre, Sebastien, Himaya, S.W.A., Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2019). Conotoxins: chemistry and biology. Chemical Reviews, 119 (21), 11510-11549. doi: 10.1021/acs.chemrev.9b00207

Ferraz, Camila R., Arrahman, Arif, Xie, Chunfang, Casewell, Nicholas R., Lewis, Richard J., Kool, Jeroen and Cardoso, Fernanda C. (2019). Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosis. Frontiers in Ecology and Evolution, 7 (JUN) 218. doi: 10.3389/fevo.2019.00218

Halbedel, Sven and Lewis, Richard J. (2019). Structural basis for interaction of DivIVA/GpsB proteins with their ligands. Molecular Microbiology, 111 (6), 1404-1415. doi: 10.1111/mmi.14244

Cardoso, Fernanda C. and Lewis, Richard J. (2019). Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channels. Frontiers in Pharmacology, 10 (APR) 366, 366. doi: 10.3389/fphar.2019.00366

Jin, Ai-hua, Cristofori-Armstrong, Ben, Rash, Lachlan D., Román González, Sergio Agustín, Espinosa, Roberto Arreguín, Lewis, Richard J., Alewood, Paul F. and Vetter, Irina (2019). Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology, 164, 342-348. doi: 10.1016/j.bcp.2019.04.025

Jin, Ai-Hua, Dutertre, Sébastien, Dutt, Mriga, Lavergne, Vincent, Jones, Alun, Lewis, Richard and Alewood, Paul (2019). Transcriptomic-proteomic correlation in the predation-evoked venom of the cone snail, Conus imperialis. Marine Drugs, 17 (3) 177, 177. doi: 10.3390/md17030177

Ziegman, Rebekah , Brust, Andreas , Jha, Prerna , Cardoso, Fernanda C. , Lewis, Richard J. and Alewood, Paul F. (2019). ‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs, 17 (3) 165, 165. doi: 10.3390/md17030165

Ragnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2019). Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors. Science Signaling, 12 (572) eaas9485, eaas9485. doi: 10.1126/scisignal.aas9485

Dutt, Mriga, Dutertre, Sébastien, Jin, Ai-Hua, Lavergne, Vincent, Alewood, Paul and Lewis, Richard (2019). Venomics reveals venom complexity of the piscivorous cone snail, Conus tulipa. Marine Drugs, 17 (1) 71, 71. doi: 10.3390/md17010071

Wang, Dan, Ragnarsson, Lotten and Lewis, Richard J. (2019). Insight into T-type calcium channel structure, function and modulation. Current medicinal chemistry, 27 (19), 3098-3122. doi: 10.2174/0929867325666181001112821

Muttenthaler, Markus, Nevin, Simon T., Inserra, Marco, Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2019). On-resin strategy to label α-Conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. Australian Journal of Chemistry, 73 (4), 327-333. doi: 10.1071/CH19456

Larsson, Michaela E., Harwood, Tim D., Lewis, Richard J., S. W. A., Himaya and Doblin, Martina A. (2019). Toxicological characterization of Fukuyoa paulensis (Dinophyceae) from temperate Australia. Phycological Research, 67 (1), 65-71. doi: 10.1111/pre.12349

Wang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert J. and Lewis, Richard J. (2018). Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers. Marine Drugs, 16 (12) 475, 475. doi: 10.3390/md16120475

Starobova, H., S. W. A., Himaya, Lewis, R. J. and Vetter, I. (2018). Transcriptomics in pain research: insights from new and old technologies. Molecular Omics, 14 (6), 389-404. doi: 10.1039/c8mo00181b

Sousa, Silmara R., McArthur, Jeffrey R., Brust, Andreas, Bhola, Rebecca F., Rosengren, K. Johan, Ragnarsson, Lotten, Dutertre, Sebastien, Alewood, Paul F., Christie, Macdonald J., Adams, David J., Vetter, Irina and Lewis, Richard J. (2018). Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports, 8 (1) 13397, 13397. doi: 10.1038/s41598-018-31245-4

Graf, Anica, Lewis, Richard J., Fuchs, Stephan, Pagels, Martin, Engelmann, Susanne, Riedel, Katharina and Pané-Farré, Jan (2018). The hidden lipoproteome of Staphylococcus aureus. International Journal of Medical Microbiology, 308 (6), 569-581. doi: 10.1016/j.ijmm.2018.01.008

Raouf, Ramin, Lolignier, Stéphane, Sexton, Jane E., Millet, Queensta, Santana-Varela, Sonia, Biller, Anna, Fuller, Alice M., Pereira, Vanessa, Choudhary, Jyoti S., Collins, Mark O., Moss, Stephen E., Lewis, Richard, Tordo, Julie, Henckaerts, Els, Linden, Michael and Wood, John N. (2018). Inhibition of somatosensory mechanotransduction by annexin A6. Science Signaling, 11 (535) eaao2060, eaao2060. doi: 10.1126/scisignal.aao2060

Abraham, Nikita and Lewis, Richard J. (2018). Neuronal nicotinic acetylcholine receptor modulators from cone snails. Marine Drugs, 16 (6) 208;, 208. doi: 10.3390/md16060208

Brust, Andreas, Wang, Ching-I. A., Daly, Norelle L., Kennerly, Joe, Sadeghi, Mahsa, Christie, Macdonald J., Lewis, Richard J., Mobli, Mehdi and Alewood, Paul F. (2018). Corrigendum to: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter (Angewandte Chemie International Edition, (2013), 52, 46, (12020-12023), 10.1002/anie.201304660). Angewandte Chemie - International Edition, 57 (19), 5203-5203. doi: 10.1002/anie.201803138

Slagboom, Julien, Otvos, Reka A., Cardoso, Fernanda C., Iyer, Janaki, Visser, Jeroen C., van Doodewaerd, Bjorn R., McCleary, Ryan J.R., Niessen, Wilfried M.A., Somsen, Govert W., Lewis, Richard J., Kini, R. Manjunatha, Smit, August B., Casewell, Nicholas R. and Kool, Jeroen (2018). Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. Toxicon, 148, 213-222. doi: 10.1016/j.toxicon.2018.04.022

Sairaman, Anjali, Cardoso, Fernanda Caldas, Bispat, Anjie, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2018). Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels. Bioorganic and Medicinal Chemistry, 26 (11), 3046-3059. doi: 10.1016/j.bmc.2018.03.031

Himaya, S. W. A. and Lewis, Richard J. (2018). Venomics-accelerated cone snail venom peptide discovery. International Journal of Molecular Sciences, 19 (3) 788, 788. doi: 10.3390/ijms19030788

Stefanucci, Azzurra, Novelino, Ettore, Macedonio, Giorgia, Dimmito, Marilia Pia, Mirzaie, Sako, Cardoso, Fernanda Caldas , Lewis, Richard, Zador, Ferenc, Erdei, Anna I., Dvoracsko, Szabolcs, Tomboly, Csaba, Benych, Sandor, Pieretti, Stefano, Minosi, Paola and Mollica, Adriano (2018). Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. New Journal of Chemistry, 42 (8), 5656-5659. doi: 10.1039/c7nj04969b

Cardoso, Fernanda C., Hasan, Mahadhi, Zhao, Tianjiao and Lewis, Richard J. (2018). Toxins in pain. Current Opinion in Supportive and Palliative Care, 12 (2), 1-10. doi: 10.1097/SPC.0000000000000335

Morgan, Michael, Deuis, Jennifer R., Woodruff, Trent M., Lewis, Richard J. and Vetter, Irina (2018). Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology, 94, 68-74. doi: 10.1016/j.molimm.2017.12.016

Himaya, S W A, Marí, Frank and Lewis, Richard J (2018). Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals. Scientific reports, 8 (1) 330, 1-8. doi: 10.1038/s41598-017-17422-x

Larsson, Michaela E., Laczka, Olivier F., Harwood, D. Tim, Lewis, Richard J., Himaya, S. W. A., Murray, Shauna A. and Doblin, Martina A. (2018). Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters. Marine Drugs, 16 (1) 7, 1-19. doi: 10.3390/md16010007

Muttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398

Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017). Conotoxin Φ-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity. Angewandte Chemie, 129 (47), 15169-15172. doi: 10.1002/ange.201708927

Adams, David J. and Lewis, Richard J. (2017). Neuropharmacology of venom peptides. Neuropharmacology, 127, 1-3. doi: 10.1016/j.neuropharm.2017.11.025

Prashanth, Jutty Rajan, Dutertre, Sebastien and Lewis, Richard James (2017). Pharmacology of predatory and defensive venom peptides in cone snails. Molecular bioSystems, 13 (12), 2453-2465. doi: 10.1039/c7mb00511c

Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017). Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity. Angewandte Chemie (International ed. in English), 56 (47), 14973-14976. doi: 10.1002/anie.201708927

Morgan, Michael, Deuis, Jennifer R., Frøsig-Jørgensen, Majbrit, Lewis, Richard J., Cabot, Peter J., Gray, Paul D. and Vetter, Irina (2017). Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment. Pain Medicine, 19 (4), 708-734. doi: 10.1093/pm/pnx228

Sousa, Silmara R., Wingerd, Joshua S., Brust, Andreas, Bladen, Christopher, Ragnarsson, Lotten, Herzig, Volker, Deuis, Jennifer R., Dutertre, Sebastien, Vetter, Irina, Zamponi, Gerald W., King, Glenn F., Alewood, Paul F. and Lewis, Richard J. (2017). Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One, 12 (9) e0182848, e0182848. doi: 10.1371/journal.pone.0182848

Touska, Filip, Sattler, Simon, Malsch, Philipp, Lewis, Richard J., Reeh, Peter W. and Zimmermann, Katharina (2017). Ciguatoxins evoke potent CGRP release by activation of voltage-gated sodium channel subtypes Na(V)1.9, Na(V)1.7 and Na(V)1.1. Marine Drugs, 15 (9) 269, 269. doi: 10.3390/md15090269

Cardoso, Fernanda Caldas and Lewis, Richard J. (2017). Sodium channels and pain: from toxins to therapies. British Journal of Pharmacology, 175 (12), 2138-2157. doi: 10.1111/bph.13962

McArthur, Jeffrey R., Motin, Leonid, Gleeson, Ellen C., Spiller, Sandro, Lewis, Richard J., Duggan, Peter J., Tuck, Kellie L. and Adams, David J. (2017). Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. British Journal of Pharmacology, 175 (12), 2284-2295. doi: 10.1111/bph.13910

Cardoso, Fernanda Caldas, Dekan, Zoltan, Smith, Jennifer J., Deuis, Jennifer R., Vetter, Irina, Herzig, Volker, Alewood, Paul F., King, Glenn F and Lewis, Richard J. (2017). Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology, 174 (15), 2528-2544. doi: 10.1111/bph.13865

Asberg, Dennis, Weinmann, Annika Langborg, Leek, Tomas, Lewis, Richard J., Klarqvist, Magnus, Lesko, Marek, Kaczmarski, Krzysztof, Samuelsson, Jorgen and Fornstedt, Torgny (2017). The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography. Journal of Chromatography A, 1496, 80-91. doi: 10.1016/j.chroma.2017.03.041

Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K. -Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J. and Rash, Lachlan D. (2017). The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.. Scientific Reports, 7 (1) 974, 974. doi: 10.1038/s41598-017-01129-0

Windley, Monique J., Vetter, Irina, Lewis, Richard J. and Nicholson, Graham M. (2017). Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors. Neuropharmacology, 127, 224-242. doi: 10.1016/j.neuropharm.2017.04.008

Abraham, Nikita, Healy, Michael, Ragnarsson, Lotten, Brust, Andreas, Alewood, Paul F. and Lewis, Richard J. (2017). Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Scientific Reports, 7 (1) 45466, 45466. doi: 10.1038/srep45466

Prashanth, Jutty Rajan, Dutertre, Sebastien and Lewis, Richard James (2017). Revising the Role of Defense and Predation in Cone Snail Venom Evolution. Evolution of Venomous Animals and Their Toxins, 105-123. doi: 10.1007/978-94-007-6458-3_18

Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551

Inserra, Marco C., Isreal, Mathilde, Caldwell, Ashlee, Castro, Joel, Deuis, Jennifer R., Harrington, Andrea M., Keramidas, Angelo, Garcia-Caraballo, Sonia, Maddern, Jessica, Erickson, Andelain, Grundy, Luke, Rychkov, Grigori Y., Zimmerman, Katharina, Lewis, Richard J., Brierley, Stuart M. and Vetter, Irina (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7 (1) 42810, 42810. doi: 10.1038/srep42810

Wan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407

Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a. Scientific Reports, 7 (1) 40883, 40883. doi: 10.1038/srep40883

Eisenblatter, Anneka, Lewis, Richard, Dorfler, Arnd, Forster, Clemens and Zimmermann, Katharina (2017). Brain mechanisms of abnormal temperature perception in cold allodynia induced by ciguatoxin. Annals of Neurology, 81 (1), 104-116. doi: 10.1002/ana.24841

Over, Bjorn, Matsson, Par, Tyrchan, Christian, Artursson, Per, Doak, Bradley C., Foley, Michael A., Hilgendorf, Constanze, Johnston, Stephen E., Lee, Maurice D., Lewis, Richard J., McCarren, Patrick, Muncipinto, Giovanni, Norinder, Ulf, Perry, Matthew W. D., Duvall, Jeremy R. and Kihlberg, Jan (2016). Structural and conformational determinants of macrocycle cell permeability. Nature Chemical Biology, 12 (12), 1065-1074. doi: 10.1038/NCHEMBIO.2203

Bressan, Elisangela, Touska, Filip, Vetter, Irina, Kistner, Katrin, Kichko, Tatjana I., Teixeira, Nathalia B., Picolo, Gisele, Cury, Yara, Lewis, Richard J., Fischer, Michael J. M., Zimmermann, Katharina and Reeh, Peter W. (2016). Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain, 157 (11), 2504-2516. doi: 10.1097/j.pain.0000000000000669

Yin, Kathleen, Deuis, Jennifer R., Lewis, Richard J. and Vetter, Irina (2016). Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. Molecular Pain, 12, 1-13. doi: 10.1177/1744806916665366

Lewis, Richard J., Inserra, Marco, Vetter, Irina, Holland, William C., Hardison, D. Ransom, Tester, Patricia A. and Litaker, R. Wayne (2016). Rapid extraction and identification of maitotoxin and ciguatoxin-like toxins from Caribbean and Pacific Gambierdiscus using a new functional bioassay. PLoS ONE, 11 (7) e0160006, e0160006. doi: 10.1371/journal.pone.0160006

Le Garrec, Raphaele, L'herondelle, Killian, Le Gall-Ianotto, Christelle, Lebonvallet, Nicolas, Leschiera, Raphael, Buhe, Virginie, Talagas, Matthieu, Vetter, Irina, Lewis, Richard J. and Misery, Laurent (2016). Release of neuropeptides from a neuro-cutaneous co-culture model: a novel in vitro model for studying sensory effects of ciguatoxins. Toxicon, 116, 4-10. doi: 10.1016/j.toxicon.2015.11.004

Abraham, Nikita, Paul, Blessy, Ragnarsson, Lotten and Lewis, Richard J. (2016). Escherichia coli protein expression system for Acetylcholine Binding Proteins (AChBPs). PLoS One, 11 (6) e0157363, e0157363. doi: 10.1371/journal.pone.0157363

Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016). Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 (22), 11829-11842. doi: 10.1074/jbc.M116.721662

Wan, Jingjing, Brust, Andreas, Bhola, Rebecca F., Jha, Prerna, Mobli, Mehdi, Lewis, Richard J., Christie, Macdonald J. and Alewood, Paul F. (2016). Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers. Journal of Peptide Science, 22 (5), 280-289. doi: 10.1002/psc.2857

Brust, Andreas, Croker, Daniel, Colless, Barbara, Ragnarsson, Lotten K. N., Andersson, Asa, Jain, Kapil, Garcia-Caraballo, Sonia, Castro, Joel, Brierley, Stuart M., Alewood, Paul F. and Lewis, Richard J. (2016). Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin a mimetics with antinociceptive properties. Journal of Medicinal Chemistry, 59 (6), 2381-2395. doi: 10.1021/acs.jmedchem.5b00911

Deuis, Jennifer R., Wingerd, Joshua S., Winter, Zoltan, Durek, Thomas, Dekan, Zoltan, Sousa, Silmara R., Zimmermann, Katharina, Hoffmann, Tali, Weidner, Christian, Nassar, Mohammed A., Alewood, Paul F., Lewis, Richard J. and Vetter, Irina (2016). Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain. Toxins, 8 (3) 78, 78. doi: 10.3390/toxins8030078

Patel, Ryan, Brice, Nicola L., Lewis, Richard J. and Dickenson, Anthony H. (2015). Ionic mechanisms of spinal neuronal cold hypersensitivity in Ciguatera. European Journal of Neuroscience, 42 (11), 3004-3011. doi: 10.1111/ejn.13098

Prashanth, J. R., Dutertre, S., Jin, A. H., Lavergne, V., Hamilton, B., Cardoso, F. C., Griffin, J., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2015). The role of defensive ecological interactions in the evolution of conotoxins. Molecular Ecology, 25 (2), 598-615. doi: 10.1111/mec.13504

Deuis, Jennifer, Whately, Ella, Brust, Andreas, Inserra, Marco, Asvadi, Naghmeh Hajarol, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2015). Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia. ACS Chemical Neuroscience, 6 (10), 1751-1758. doi: 10.1021/acschemneuro.5b00113

Himaya S.W.A., Jin, Ai-Hua, Dutertre, Sebastien, Giacomotto, Jean, Mohialdeen, Hoshyar, Vetter, Irina, Alewood, Paul F. and Lewis, Richard J. (2015). Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research, 14 (10), 4372-4381. doi: 10.1021/acs.jproteome.5b00630

Prashanth, Jutty Rajan and Lewis, Richard J. (2015). An efficient transcriptome analysis pipeline to accelerate venom peptide discovery and characterisation. Toxicon, 107 (Pt B), 282-289. doi: 10.1016/j.toxicon.2015.09.012

Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178

Jin, Ai-Hua, Israel, Mathilde R., Inserra, Marco, Smith, Jennifer J., Lewis, Richard J., Alewood, Paul F., Vetter, Irina and Dutertre, Sebastien (2015). δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings of the Royal Society B: Biological Sciences, 282 (1811) 20150817, 1-8. doi: 10.1098/rspb.2015.0817

Rodriguez, Alena M., Dutertre, Sebastian, Lewis, Richard J. and Mari, Frank (2015). Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS. Analytical and Bioanalytical Chemistry, 407 (20), 6105-6116. doi: 10.1007/s00216-015-8787-y

Klint, Julie K., Smith, Jennifer J., Vetter, Irina, Rupasinghe, Darshani B., Er, Sing Yan, Senff, Sebastian, Herzig, Volker, Mobli, Mehdi, Lewis, Richard J., Bosmans, Frank and King, Glenn F. (2015). Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology, 172 (10), 2445-2458. doi: 10.1111/bph.13081

Gleeson, Ellen C., Graham, Janease E., Spiller, Sandro, Vetter, Irina, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2015). Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives. Marine Drugs, 13 (4), 2030-2045. doi: 10.3390/md13042030

Mueller, Alexander, Starobova, Hana, Inserra, Marco C., Jin, Ai-Hua, Deuis, Jennifer R., Dutertre, Sebastien, Lewis, Richard J., Alewood, Paul F., Daly, Norelle L. and Vetter, Irina (2015). α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology, 94 (2), 155-163. doi: 10.1016/j.bcp.2015.01.011

Murali, Swetha S., Napier, Ian A., Mohammadi, Sarasa A., Alewood, Paul F., Lewis, Richard J. and Christie, MacDonald J. (2015). High-voltage activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury. Journal of Neurophysiology, 113 (5), 1511-1519. doi: 10.1152/jn.00608.2014

Yin, Kathleen, Zimmermann, Katharina, Vetter, Irina and Lewis, Richard J. (2015). Therapeutic opportunities for targeting cold pain pathways. Biochemical Pharmacology, 93 (2), 125-140. doi: 10.1016/j.bcp.2014.09.024

Gori, Alessandro, Wang, Ching-I A., Harvey, Peta J., Rosengren, K. Johan, Bhola, Rebecca F., Gelmi, Maria L., Longhi, Renato, Christie, Macdonald J., Lewis, Richard J., Alewood, Paul F. and Brust, Andreas (2015). Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic. Angewandte Chemie - International Edition, 54 (4), 1361-1364. doi: 10.1002/anie.201409678

Ragnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2015). Extracellular surface residues of theα1b-adrenoceptor critical for g protein -coupled receptor functions. Molecular Pharmacology, 87 (1), 121-129. doi: 10.1124/mol.114.094557

Wan, Jingjing, Huang, Johnny X., Vetter, Irina, Mobli, Mehdi, Lawson, Joshua, Tae, Han-Shen, Abraham, Nikita, Paul, Blessy, Cooper, Matthew A., Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2015). α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society, 137 (9), 3209-3212. doi: 10.1021/jacs.5b00244

Jin, Ai-Hua, Vetter, Irina, Himaya, Siddhihalu W. A., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2015). Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics, 15 (23-24), 4030-4040. doi: 10.1002/pmic.201500220

Mollica, Adriano, Costante, Roberto, Novellino, Ettore, Stefanucci, Azzurra, Pieretti, Stefano, Zador, Ferenc, Samavati, Reza, Borsodi, Anna, Benyhe, Sandor, Vetter, Irina and Lewis, Richard J. (2014). Design, synthesis and biological evaluation of two opioid agonist and Cav2.2 blocker multitarget ligands. Chemical Biology and Drug Design, 86 (2), 156-162. doi: 10.1111/cbdd.12479

Dutertre, Sebastien, Jin, Ai-Hua, Alewood, Paul F. and Lewis, Richard J. (2014). Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose. Toxicon, 91, 135-144. doi: 10.1016/j.toxicon.2014.09.011

Cleverley, Robert M., Barrett, Jeffrey R., Baslé, Arnaud, Bui, Nhat Khai, Hewitt, Lorraine, Solovyova, Alexandra, Xu, Zhi-Qiang, Daniel, Richard A., Dixon, Nicholas E., Harry, Elizabeth J., Oakley, Aaron J., Vollmer, Waldemar and Lewis, Richard J. (2014). Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nature Communications, 5 (1) 5421. doi: 10.1038/ncomms6421

Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sebastien and Lewis, Richard J. (2014). Cone snail venomics: From novel biology to novel therapeutics. Future Medicinal Chemistry, 6 (15), 1659-1675. doi: 10.4155/FMC.14.99

Karas, John A., Scanlon, Denis B., Forbes, Briony E., Vetter, Irina, Lewis, Richard J., Gardiner, James, Separovic, Frances, Wade, John D. and Hossain, Mohammed A. (2014). 2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin.. Chemistry: A European Journal, 20 (31), 9549-9552. doi: 10.1002/chem.201403574

Wang, Ching-I Anderson, Reeks, Timothy, Vetter, Irina, Vergara, Irene, Kovtun, Oleksiy, Lewis, Richard J., Alewood, Paul F. and Durek, Thomas (2014). Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry, 53 (23), 3758-3766. doi: 10.1021/bi5004475

Akondi, Kalyana, Muttenthaler, Markus, Dutertre, Sébastien, Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2014). Discovery, synthesis, and structure: activity relationships of conotoxins. Chemical Reviews, Articles ASAP (11), 1-33. doi: 10.1021/cr400401e

Dutertre, Sébastien, Jin, Ai-Hua, Vetter, Irina, Hamilton, Brett, Sunagar, Kartik, Lavergne, Vincent, Dutertre, Valentin, Fry, Bryan G., Antunes, Agostinho, Venter, Deon J., Alewood, Paul F. and Lewis, Richard J. (2014). Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nature Communications, 5 (3521) 3521, 1-9. doi: 10.1038/ncomms4521

Heus, Ferry, Otvos, Reka A., Aspers, Ruud L. E. G., van Elk, Rene, Halff, Jenny I., Ehlers, Andreas W., Dutertre, Sébastien, Lewis, Richard J., Wijmenga, Sybren, Smit, August B., Niessen, Wilfried M. A. and Kool, Jeroen (2014). Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail. Biology, 3 (1), 139-156. doi: 10.3390/biology3010139

Jin, Ai-Hua, Vetter, Irina, Dutertre, Sébastien, Abraham, Nikita, Emidio, Nayara B., Inserra, Marco, Murali, Swetha S., Christie, MacDonald J., Alewood, Paul F. and Lewis, Richard J. (2014). MrIC, a novel alpha-conotoxin agonist in the presence of PNU at endogenous alpha-7 nicotinic acetylcholine receptors. Biochemistry, 53 (1), 1-3. doi: 10.1021/bi400882s

Manger, Ronald, Woodle, Doug, Berger, Andrew, Dickey, Robert W., Jester, Edward, Yasumoto, Takesh, Lewis, Richard, Hawryluk, Timothy and Hungerford, James (2014). Flow cytometric-membrane potential detection of sodium channel active marine toxins: application to ciguatoxins in fish muscle and feasibility of automating saxitoxin detection. Journal of AOAC International, 97 (2), 299-306. doi: 10.5740/jaoacint.SGEManger

Deuis, Jennifer R., Lim, Yu Ling, Rodrigues de Sousa, Silmara, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2014). Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin. Neuro-Oncology, 16 (10), 1324-1332. doi: 10.1093/neuonc/nou048

Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sébastien and Lewis, Richard J. (2014). Erratum: Cone snail venomics: From novel biology to novel therapeutics (Future Medicinal Chemistry (2014) 6:15 (1659-1675)). Future Medicinal Chemistry, 6 (18). doi: 10.4155/fmc.14.159

Hopping, Gene, Wang, C-I Anderson, Hogg, Ron C., Nevin, Simon T., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2014). Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology, 91 (4), 534-542. doi: 10.1016/j.bcp.2014.07.025

Dantas De Araujo, Aline, Mobli, Mehdi, Castro, Joel, Harrington, Andrea M., Vetter, Irina, Dekan, Zoltan, Muttenthale, Markus, Wan, JingJing, Lewis, Richard J., King, Glenn F., Brierley, Stuart M. and Alewood, Paul F. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications, 5 (1) 3165, 3165.1-3165.12. doi: 10.1038/ncomms4165

Jin, Ai-Hua, Dutertre, Sébastien, Kaas, Quentin, Lavergne, Vincent, Kubala, Petra, Lewis, Richard J. and Alewood, Paul F. (2013). Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Molecular and Cellular Proteomics, 12 (12), 3824-3833. doi: 10.1074/mcp.M113.030353

Skinner, Mark P., Lewis, Richard J. and Morton, Steve (2013). Ecology of the ciguatera causing dinoflagellates from the Northern Great Barrier Reef: Changes in community distribution and coastal eutrophication. Marine Pollution Bulletin, 77 (1-2), 210-219. doi: 10.1016/j.marpolbul.2013.10.003

Brust, Andreas, Wang, Ching-I. A., Daly, Norelle L., Kennerly, Joe, Sadeghi, Mahsa, Christie, Macdonald J., Lewis, Richard J., Mobli, Mehdi and Alewood, Paul F. (2013). Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter. Angewandte Chemie (International Edition), 52 (46), 12020-12023. doi: 10.1002/anie.201304660

Sadeghi, Mahsa, Murali, Swetha S., Lewis, Richard J., Alewood, Paul F., Mohammadi, Sarasa and Christie, MacDonald J. (2013). Novel omega-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration. Molecular Pain, 9 (1) 51, 51.1-51.8. doi: 10.1186/1744-8069-9-51

Zimmermann, Katharina, Deuis, Jennifer R., Inserra, Marco C., Collins, Lindon S., Namer, Barbara, Cabot, Peter J., Reeh, Peter W., Lewis, Richard J. and Vetter, Irina (2013). Analgesic treatment of ciguatoxin-induced cold allodynia. Pain, 154 (10), 1999-2006. doi: 10.1016/j.pain.2013.06.015

Vetter, Irina, Hein, Alexander, Sattler, Simon, Hessler, Sabine, Touska, Filip, Bressan, Elisangela, Parra, Andres, Hager, Ulrich, Leffler, Andreas, Boukalova, Stepana, Nissen, Matthias, Lewis, Richard J., Belmonte, Carlos, Alzheimer, Christian, Huth, Tobias, Vlachova, Viktorie, Reeh, Peter W. and Zimmermann, Katharina (2013). Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition. Journal of Neuroscience, 33 (42), 16627-16641. doi: 10.1523/JNEUROSCI.1473-13.2013

Lavergne, Vincent, Dutertre, Sebastien, Jin, Ai-hua, Lewis, Richard J., Taft, Ryan J. and Alewood, Paul F. (2013). Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. Bmc Genomics, 14 (1) 708, 708.1-708.11. doi: 10.1186/1471-2164-14-708

Deuis, Jennifer R., Zimmermann, Katharina, Romanovsky, Andrej A., Possani, Lourival D., Cabot, Peter J., Lewis, Richard J. and Vetter, Irina (2013). An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways. Pain, 154 (9), 1749-1757. doi: 10.1016/j.pain.2013.05.032

Inserra, Marco C., Kompella, Shiva N., Vetter, Irina, Brust, Andreas, Daly, Norelle L., Cuny, Hartmut, Craik, David J., Alewood, Paul F., Adams, David J. and Lewis, Richard J. (2013). Isolation and characterization of alpha-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology, 86 (6), 791-799. doi: 10.1016/j.bcp.2013.07.016

Jayamanne, A., Jeong, H. J., Schroeder, C. I., Lewis, R. J., Christie, M. J. and Vaughan, C. W. (2013). Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. British Journal of Pharmacology, 170 (2), 245-254. doi: 10.1111/bph.12251

Akondi, Kalyana B., Lewis, Richard J. and Alewood, Paul F. (2013). Re-engineering the mu-conotoxin SIIIA scaffold. Biopolymers, Accepted Article (4), 1-21. doi: 10.1002/bip.22368

Durek, Thomas, Vetter, Irina, Wang, Ching-I Anderson, Motin, Leonid, Knapp, Oliver, Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2013). Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1. ACS Chemical Biology, 8 (6), 1215-1222. doi: 10.1021/cb400012k

Smith, Jennifer J., Vetter, Irina, Lewis, Richard J., Peigneur, Steve, Tytgat, Jan, Lam, Alexander, Gallant, Esther M., Beard, Nicole A., Alewood, Paul F. and Dulhunty, Angela F. (2013). Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins. Proceedings of the National Academy of Sciences of the United States of America, 110 (22), 8906-8911. doi: 10.1073/pnas.1214062110

Sousa, Silmara R., Vetter, Irina, Ragnarsson, Lotten and Lewis, Richard J. (2013). Expression and pharmacology of endogenous Ca-v channels in SH-SY5Y human neuroblastoma cells. PloS One, 8 (3) e59293, e59293. doi: 10.1371/journal.pone.0059293

Brust, Andreas, Sunagar, Kartik, Eivind Undheim, Vetter, Irina, Yang, Daryl C., Casewell, Nicholas R., Ruder, Tim, Jackson, Timothy N. W., Koludarov, Ivan, Alewood, Paul F., Hodgson, Wayne C., Lewis, Richard J., King, Glenn F., Antunes, Agostinho, Hendrikx, Iwan and Fry, Bryan G. (2013). Differential evolution and neofunctionalization of snake venom metalloprotease domains. Molecular and Cellular Proteomics, 12 (3), 651-663. doi: 10.1074/mcp.M112.023135

Sousa, Silmara R., Vetter, Irina and Lewis, Richard J. (2013). Venom peptides as a rich source of Cav2.2 channel blockers. Toxins, 5 (2), 286-314. doi: 10.3390/toxins5020286

Dutertre, Sebastien, Jin, Ai-Hua (Jean), Kaas, Quentin, Jones, Alun, Alewood, Paul F. and Lewis, Richard J. (2013). Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Molecular and Cellular Proteomics, 12 (2), 312-329. doi: 10.1074/mcp.M112.021469

Wang, Ching-I. Anderson and Lewis, Richard J. (2013). Emerging opportunities for allosteric modulation of G-protein coupled receptors. Biochemical Pharmacology, 85 (2), 153-162. doi: 10.1016/j.bcp.2012.09.001

Ghassemian, Artin, Wang, Ching-I Anderson, Yau, Mei-Kwan, Reid, Robert C., Lewis, Richard J., Fairlie, David P., Alewood, Paul F. and Durek, Thomas (2013). Efficient chemical synthesis of human complement protein C3a. Chemical Communications, 49 (23), 2356-2358. doi: 10.1039/c3cc40537k

Ragnarsson, Lotten, Wang, Ching-I Anderson, Andersson, Asa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2013). Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor. Journal of Biological Chemistry, 288 (3), 1814-1827. doi: 10.1074/jbc.M112.430785

Brust, Andreas, Sunagar, Kartik, Undheim, Eivind A. B., Vetter, Irina, Yang, Daryl C., Casewell, Nicholas R., Jackson, Timothy N. W., Koludarov, Ivan, Alewood, Paul F., Hodgson, Wayne C., Lewis, Richard J., King, Glenn F., Antunes, Agostinho, Hendrikx, Iwan and Fry, Bryan G. (2012). Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains (vol 12, pg 651, 2013). Molecular & Cellular Proteomics, 12 (5), 1488-1488. doi: 10.1074/mcp.M112.023135

Wang, Ching-I A., Shaikh, Nausad H., Ramu, Soumya and Lewis, Richard J. (2012). A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter. Molecular Pharmacology, 82 (5), 898-909. doi: 10.1124/mol.112.080630

Vetter, Irina, Touska, Filip, Hess, Andreas, Hinsbey, Rachel, Sattler, Simon, Lampert, Angelika, Sergejeva, Marina, Sharov, Anastasia, Collins, Lindon S., Eberhardt, Mirjam, Engel, Matthias, Cabot, Peter J., Wood, John N., Vlachova, Viktorie, Reeh, Peter W., Lewis, Richard J. and Zimmermann, Katharina (2012). Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO Journal, 31 (19), 3795-3808. doi: 10.1038/emboj.2012.207

Tranberg, Charlotte Elisabet, Yang, Aijun, Vetter, Irina, McArthur, Jeffrey R., Baell, Jonathan B., Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2012). omega-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Ca(v)2.2 Ion Channels. Marine Drugs, 10 (10), 2349-2368. doi: 10.3390/md10102349

Jutty Rajan, Prashanth, Lewis, Richard J. and Dutertre, Sebastien (2012). Towards an integrated venomics approach for accelerated conopeptide discovery. Toxicon, 60 (4), 470-477. doi: 10.1016/j.toxicon.2012.04.340

Marcon, Francesca, Leblanc, Mathieu, Vetter, Irina, Lewis, Richard J., Escoubas, Pierre and Nicholson, Graham M. (2012). Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors. Biochemical Pharmacology, 84 (6), 851-863. doi: 10.1016/j.bcp.2012.06.024

Vetter, Irina, Dekan, Zoltan, Knapp, Oliver, Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2012). Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochemical Pharmacology, 84 (4), 540-548. doi: 10.1016/j.bcp.2012.05.008

Knapp, O., Nevin, S. T., Yasuda, T., Lawrence, N., Lewis, R. J. and Adams, D. J. (2012). Biophysical properties of Naᵥ 1.8/Naᵥ 1.2 chimeras and inhibition by µO-conotoxin MrVIB. British Journal of Pharmacology, 166 (7), 2148-2160. doi: 10.1111/j.1476-5381.2012.01955.x

Muttenthaler, Markus, Dutertre, Sebastien, Wingerd, Joshua S., Aini, John W., Walton, Hugh, Alewood, Paul F. and Lewis, Richard J. (2012). Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea. Nautilus, 126 (2), 47-56.

Vetter, Irina and Lewis, Richard J. (2012). Therapeutic potential of cone snail venom peptides (conopeptides). Current Topics in Medicinal Chemistry, 12 (14), 1546-1552. doi: 10.2174/156802612802652457

Vetter, Irina, Mozar, Christine A., Durek, Thomas, Wingerd, Joshua S., Alewood, Paul F., Christie, Macdonald J. and Lewis, Richard J. (2012). Characterisation of Na-v types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology, 83 (11), 1562-1571. doi: 10.1016/j.bcp.2012.02.022

Lewis, Richard J., Dutertre, Sebastien, Vetter, Irina and Christie, MacDonald J. (2012). Conus venom peptide pharmacology. Pharmacological Reviews, 64 (2), 259-298. doi: 10.1124/pr.111.005322

Lewis, Richard J. (2012). Discovery and development of the chi-conopeptide class of analgesic peptides. Toxicon, 59 (4), 524-528. doi: 10.1016/j.toxicon.2011.07.012

Dekan, Zoltan, Wang, Ching-I Anderson, Andrews, Robert K., Lewis, Richard J. and Alewood, Paul F. (2012). Conotoxin engineering: Dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability. Organic and Biomolecular Chemistry, 10 (30), 5791-5794. doi: 10.1039/c2ob25133g

Schroeder, Christina I., Adams, Denise, Thomas, Linda, Alewood, Paul F. and Lewis, Richard J. (2012). N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers, 98 (2), 161-165. doi: 10.1002/bip.22032

Schroeder, Christina I., Nielsen, Katherine J., Adams, Denise A., Loughnan, Marion L., Thomas, Linda, Alewood, Paul F., Lewis, Richard J. and Craik, David J. (2012). Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers, 98 (4), 345-356. doi: 10.1002/bip.22031

Skinner, Mark P., Brewer, Tom D., Johnstone, Ron, Fleming, Lora E. and Lewis, Richard J. (2011). Ciguatera fish poisoning in the Pacific Islands (1998 - 2008). PLoS Neglected Tropical Diseases, 5 (12) e1416, e1416.1-e1416.7. doi: 10.1371/journal.pntd.0001416

Inserra, Marco C. and Lewis, Richard J. (2011). Venom peptide modulators of the immune system. Inflammation and Allergy - Drug Targets, 10 (5), 399-410. doi: 10.2174/187152811797200687

Dekan, Zoltan, Vetter, Irina, Daly, Norelle L., Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2011). α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Journal of the American Chemical Society, 133 (40), 15866-15869. doi: 10.1021/ja206408q

Vetter, Irina, Davis, Jasmine L., Rash, Lachlan D., Anangi, Raveendra, Mobli, Mehdi, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2011). Venomics: A new paradigm for natural products-based drug discovery. Amino Acids, 40 (1), 15-28. doi: 10.1007/s00726-010-0516-4

Muttenthaler, Markus, Andersson, Asa, Dantas de Araujo, Aline, Dekan, Zoltan, Lewis, Richard J. and Alewood, Paul F. (2010). Modulating oxytocin activity and plasma stability by disulfide bond engineering. Journal of Medicinal Chemistry, 53 (24), 8585-8596. doi: 10.1021/jm100989w

Stewart, I., Lewis, Richard J., Eaglesham, G. K., Graham, G. C., Poole, S. and Craig, S. B. (2010). Emerging tropical diseases in Australia. Part 2. Ciguatera fish poisoning. Annals of Tropical Medicine & Parasitology, 104 (7), 557-571. doi: 10.1179/136485910X12851868779902

Hamilton, Brett, Whittle, Nigel, Shaw, Glen, Eaglesham, Geoff, Moore, Michael R. and Lewis, Richard J. (2010). Human fatality associated with Pacific ciguatoxin contaminated fish. Toxicon, 56 (5), 668-673. doi: 10.1016/j.toxicon.2009.06.007

Mattei, Cesar, Marquais, Michel, Schlumberger, Sebastien, Molgo, Jordi, Vernoux, Jean-Paul, Lewis, Richard J. and Benoit, Evelyne (2010). Analysis of Caribbean ciguatoxin-1 effects on frog myelinated axons and the neuromuscular junction. Toxicon, 56 (5), 759-767. doi: 10.1016/j.toxicon.2009.07.026

Nguyen-Huu, Truong D., Mattei, César, Wen, Peter J., Bourdelais, Andrea J., Lewis, Richard J., Benoit, Evelyne, Baden, Daniel G., Molgó, Jordi and Meunier, Frédéric A. (2010). Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal. Toxicon, 56 (5), 792-796. doi: 10.1016/j.toxicon.2009.08.002

Morales, Rodrigo A. V., Daly, Norelle L., Vetter, Irina, Mobli, Mehdi, Napier, Ian A., Craik, David J., Lewis, Richard J., Christie, MacDonald J., King, Glenn F., Alewood, Paul F. and Durek, Thomas (2010). Chemical synthesis and structure of the prokineticin Bv8. ChemBioChem, 11 (13), 1882-1888. doi: 10.1002/cbic.201000330

Lewis, Richard J. and Poli, Mark (2010). Toxins in Seafood. Toxicon, 56 (2), 107-107. doi: 10.1016/j.toxicon.2010.05.002

Grishin, Anton, Wang, Ching-I. A., Muttenthaler, Markus, Alewood, Paul F., Lewis, Richard J. and Adams, David J. (2010). α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 285 (29), 22254-22263. doi: 10.1074/jbc.M110.111880

Dutertre, Sébastien and Lewis, Richard J. (2010). Use of venom peptides to probe ion channel structure and function. Journal of Biological Chemistry, 285 (18), 13315-13320. doi: 10.1074/jbc.R109.076596

Luo, Sulan, Akondi, Kalyana Bharati, Zhangsun, Dongting, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Christensen, Sean, Dowell, Cheryl, Daly, Norelle L., Craik, David J., Wang, Ching-I. Anderson, Lewis, Richard J., Alewood, Paul F. and McIntosh, J. Michael (2010). Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha 3 beta 2 nicotinic receptor. Journal of Biological Chemistry, 285 (16), 12355-12366. doi: 10.1074/jbc.M109.079012

Wang, Ching-I Anderson and Lewis, Richard J. (2010). Emerging structure-function relationships defining monoamine NSS transporter substrate and ligand affinity. Biochemical Pharmacology, 79 (8), 1083-1091. doi: 10.1016/j.bcp.2009.11.019

Muttenthaler, Marcus, Nevin, Simon T., Grishin, Anton A., Ngo, Shyuan T., Choy, Peng T., Daly, Norelle L., Hu, Shu-Hong, Armishaw, Christopher J., Wang, Ching-I. A., Lewis, Richard J., Martin, Jennifer L., Noakes, Peter G., Craik, David J., Adams, David J. and Alewood, Paul F. (2010). Solving the alpha-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists. Journal of the American Chemical Society, 132 (10), 3514-3522. doi: 10.1021/ja910602h

Vetter, Irina and Lewis, Richard J. (2010). Characterization of endogenous calcium responses in neuronal cell lines. Biochemical Pharmacology, 79 (6), 908-920. doi: 10.1016/j.bcp.2009.10.020

Berecki, G., Motin, L., Haythornthwaite, A., Vink, S., Bansal, P., Drinkwater, R., Wang, C. I., Moretta, M., Lewis, R. J., Alewood, P. F., Christie, M. J. and Adams, D. J. (2009). Analgesic omega-conotoxins CVIE and CVIF selectively and voltage dependently block recombinant and native N-type calcium channels. Molecular Pharmacology, 77 (2), 139-148. doi: 10.1124/mol.109.058834

Lewis, Richard J., Yang, Aijun and Jones, Alun (2009). Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh (vol 54, pg 62, 2009). Toxicon, 54 (6), 897-897. doi: 10.1016/j.toxicon.2009.06.025

Hopping , Gene, Lewis, Richard J. and Alewood, Paul F. (2009). Rapid access to omega conotoxin chimeras using native chemical ligation. Austalian Journal of Chemistry, 62 (10), 1333-1338. doi: 10.1071/CH09216

Brust, Andreas, Palant, Elka, Croker, Daniel E., Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I., Wilson, David, Nielsen, Carsten K., Smith, Maree T., Alewood, Danne, Alewood, Paul F and Lewis, Richard J. (2009). X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry, 52 (22), 6991-7002. doi: 10.1021/jm9003413

Andersson, Asa, Baell, Jonathan B., Duggan, Peter J., Graham, Janease E., Lewis, Richard J., Lumsden, Natalie G., Tranberg, C. Elisabet, Tuck, Kellie L. and Yang, Aijun (2009). Omega-Conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine. Bioorganic and Medicinal Chemistry, 17 (18), 6659-6670. doi: 10.1016/j.bmc.2009.07.063

Fry, Bryan G., Roelants, Kim, Champagne, Donald E., Scheib, Holger, Tyndall, Joel D. A., King, Glenn F., Nevalainen, Timo J., Norman, Janette A., Lewis, Richard J., Norton, Raymond S., Renjifo, Camila and Rodriguez de la Vega, Ricardo C. (2009). The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms. Annual Review of Genomics and Human Genetics, 10, 483-511. doi: 10.1146/annurev.genom.9.081307.164356

Chan, L. Y., Wang, C. K., Major, J. M., Greenwood, K. P., Lewis, R. J., Craik, D. J. and Daly, N. L. (2009). Isolation and characterization of peptides from momordica cochinchinensis seeds. JOURNAL OF NATURAL PRODUCTS, 72 (8), 1453-1458. doi: 10.1021/np900174n

Davis, J, Jones, Al and Lewis, R. J. (2009). Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides, 30 (7), 1222-1227. doi: 10.1016/j.peptides.2009.03.019

Loughnan, Marion L., Nicke, Annette, Lawrence, Nicole and Lewis, Richard J. (2009). Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry, 48 (17), 3717-3729. doi: 10.1021/bi9000326

Duggan, P. J., Lewis, R. J., Lok, Y. P., Lumsden, N. G., Tuck, K. L. and Yang, A. J. (2009). Low molecular weight non-peptide mimics of omega-conotoxin GVIA. Bioorganic and Medicinal Chemistry Letters, 19 (10), 2763-2765. doi: 10.1016/j.bmcl.2009.03.130

Lewis, Richard J (2009). Conotoxins: molecular and therapeutic targets. Progress in molecular and subcellular biology, 46, 45-65. doi: 10.1007/978-3-540-87895-7_2

Zamponi, G. W., Lewis, R. J., Todorovic, S. M., Arneric, S. P. and Snutch, T. P. (2009). Role of voltage-gated calcium channels in ascending pain pathways. Brain Research Revues, 60 (1), 84-89. doi: 10.1016/j.brainresrev.2008.12.021

Lewis, Richard J., Yang, Aijun and Jones, Alun (2009). Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins fish flesh. Toxicon, 54 (1), 62-66. doi: 10.1016/j.toxicon.2009.03.013

Millard, Emma L., Nevin, Simon T., Loughnan, Marion L., Nicke, Annette, Clark, Richard J., Alewood, Paul F., Lewis, Richard J., Adams, David J., Craik, David J. and Daly, Norelle L. (2009). Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analogues. Journal of Biological Chemistry, 284 (8), 4944-4951. doi: 10.1074/jbc.M804950200

Lewis, RJ (2009). Conotoxin Venom Peptide Therapeutics. Advances in Experimental Medicine & Biology, 655 (x), 44-48. doi: 10.1007/978-1-4419-1132-2_5

Mattei, C, Wen, PJ, Nguyen-Huu, TD, Alvarez, M, Benoit, E, Bourdelais, AJ, Lewis, RJ, Baden, DG, Molgo, J and Meunier, FA (2008). Brevenal Inhibits Pacific Ciguatoxin-1B-Induced Neurosecretion from Bovine Chromaffin Cells. PLoS One, 3 (10) e3448, 1-16. doi: 10.1371/journal.pone.0003448

Zhang, Hua, Major, Jodie M., Lewis, Richard J. and Capon, Robert J. (2008). Phorbasins G-K: new cytotoic diterpenes from a southern Australian marine sponge, Phorbas sp. Organic and Biomolecular Chemistry, 6 (20), 3811-3815. doi: 10.1039/b808866g

Jin, Ai-Hua, Daly, N. L., Nevin, S. T., Wang, C. I. A., Dutertre, S., Lewis, R. J., Adams, D. J., Craik, D. J. and Alewood, P. F. (2008). Molecular engineering of conotoxins: The importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry, 51 (18), 5575-5584. doi: 10.1021/jm800278k

Dumon, Claire, Varvak, Alexander, Wall, Mark A., Flint, James E., Lewis, Richard J., Lakey, Jeremy H., Morland, Carl, Luginbühl, Peter, Healey, Shaun, Todaro, Thomas, DeSantis, Grace, Sun, May, Parra-Gessert, Lilian, Tan, Xuqiu, Weiner, David P. and Gilbert, Harry J. (2008). Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure. Journal of Biological Chemistry, 283 (33), 22557-22564. doi: 10.1074/jbc.M800936200

Schroeder, C.I, Ekberg, J, Nielsen, K.J, Adams, D, Loughnan, M L, Thomas, L, Adams, D J, Alewood, P F and Lewis, R J (2008). Neuronally selective micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. Journal of Biological Chemistry, 283 (31), 21621-21628. doi: 10.1074/jbc.M802852200

Correia, Márcia A.S., Prates, José A.M., Brás, Joana, Fontes, Carlos M.G.A., Newman, Joseph A., Lewis, Richard J., Gilbert, Harry J. and Flint, James E. (2008). Crystal Structure of a Cellulosomal Family 3 Carbohydrate Esterase from Clostridium thermocellum Provides Insights into the Mechanism of Substrate Recognition. Journal of Molecular Biology, 379 (1), 64-72. doi: 10.1016/j.jmb.2008.03.037

Dutertre, Sébastien, Croker, Daniel, Daly, Norelle L., Andersson, Åsa, Muttenthaler, Markus, Lumsden, Natalie G., Craik, David J., Alewood, Paul F., Guillon, Gilles and Lewis, Richard J. (2008). Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptide. Journal of Biological Chemistry, 283 (11), 7100-7108. doi: 10.1074/jbc.M706477200

Quin, Maureen, Newman, Joseph, Firbank, Susan, Lewis, Richard J. and Marles-Wright, Jon (2008). Crystallization and preliminary X-ray analysis of RsbS from Moorella thermoacetica at 2.5 Å resolution. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64 (3), 196-199. doi: 10.1107/S1744309108003849

Vardakou, Maria, Dumon, Claire, Murray, James W., Christakopoulos, Paul, Weiner, David P., Juge, Nathalie, Lewis, Richard J., Gilbert, Harry J. and Flint, James E. (2008). Understanding the Structural Basis for Substrate and Inhibitor Recognition in Eukaryotic GH11 Xylanases. Journal of Molecular Biology, 375 (5), 1293-1305. doi: 10.1016/j.jmb.2007.11.007

Duggan, PJ, Faber, JM, Graham, JE, Lewis, RJ, Lumsden, NG and Tuck, KL (2008). Synthesis and Ca(v)2.2 binding data for non-peptide mimetics of omega-conotoxin GVIA based on a 5-amino-anthranilamide core. Australian Journal of Chemistry: an international journal for chemical science, 61 (1), 11-15. doi: 10.1071/CH07327

Marles-Wright, Jon and Lewis, Richard J (2007). Stress responses of bacteria. Current Opinion in Structural Biology, 17 (6), 755-760. doi: 10.1016/j.sbi.2007.08.004

Blanchfield, J., Gallagher, O., Cros, C., Lewis, R., Alewood, P. and Toth, I. (2007). Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue. Biochemical and Biophysical Research Communication, 361 (1), 97-102. doi: 10.1016/j.bbrc.2007.06.138

Drew, Liam J., Rugiero, Francois, Cesare, Paolo, Gale, Jonathan E., Abrahamsen, Bjarke, Bowden, Sarah, Heinzmann, Sebestian, Robinson, Michelle, Brust, Andreas, Colless, Barbara, Lewis, Richard J. and Wood, John N. (2007). High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One, 2 (6) e515, 1-11. doi: 10.1371/journal.pone.0000515

Lewis, Richard J., Schroeder, Christina I., Ekberg, Jenny, Nielsen, Katherine J., Loughnan, Marion, Thomas, Linda, Adams, Denise A., Drinkwater, Roger, Adams, David J. and Alewood, Paul F. (2007). Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Molecular Pharmacology, 71 (3), 676-685. doi: 10.1124/mol.106.028225

Paczkowski, Filip A., Sharpe, Iain A., Dutertre, Sébastien and Lewis, Richard J. (2007). chi-conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model. Journal of Biological Chemistry, 282 (24), 17837-17844. doi: 10.1074/jbc.M610813200

Dekan, Z., Paczkowski, F. A., Lewis, R. J and Alewood, P. F. (2007). Synthesis and In vitro biological activity of cyclic lipophilic χ-conotoxin MrIA analogues. International Journal of Peptide Research And Therapeutics, 13 (1-2), 307-312. doi: 10.1007/s10989-007-9083-2

Dutertre, S., Ulens, C, Buttner, R, Fish, A, van Elk, R, Kendel, Y, Hopping, G., Alewood, P. F., Schroeder, C., Nicke, A, Smit, AB, Sixma, TK and Lewis, R. J. (2007). AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. Embo Journal, 26 (16), 3858-3867. doi: 10.1038/sj.emboj.7601785

Motin, Leonid, Yasuda, Takahiro, Schroeder, Christina I., Lewis, Richard J. and Adams, David J. (2007). omega-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels. European Journal of Neuroscience, 25 (2), 435-444. doi: 10.1111/j.1460-9568.2006.05299.x

St Pierre, Liam, Flight, Simone M., Masci, Paul P., Hanchard, Kim J., Lewis, Richard J., Alewood, Paul F., De Jersey, John and Lavin, Martin F. (2006). Cloning and characterization of natriuretic peptides from the venom glands of Australian elapids. Biochimie, 88 (12), 1923-1931. doi: 10.1016/j.biochi.2006.06.014

Ekberg, J., Jayamanne, A., Vaughan, C. W., Aslan, S., Thomas, L., Mould, J., Drinkwater, R., Baker, M. D., Abrahamsen, B., Wood, J. N., Adams, D. J., Christie, M. J. and Lewis, R. J. (2006). mu O-conotoxin MrVIB selectively blocks Na(v)1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proceedings of The National Academy of Sciences of The United States of America, 103 (45), 17030-17035. doi: 10.1073/pnas.0601819103

Schroeder, I. C., Doering, J., Zamponi, W. and Lewis, R. J. (2006). N-type calcium channel blockers: Novel therapeutics for the treatment of pain. Medicinal Chemistry, 2 (5), 535-543. doi: 10.2174/157340606778250216

Loughnan, Marion, Nicke, Annette, Jones, Alun, Schroeder, Christina I., Nevin, Simon T., Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2006). Identification of a novel class of nicotinic receptor antagonists - Dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. Journal of Biological Chemistry, 281 (34), 24745-24755. doi: 10.1074/jbc.M603703200

Baell, Jonathan B., Duggan, Peter J., Forsyth, Stewart A., Lewis, Richard J., Lok, Y. Phei, Schroeder, Christina I. and Shepherd, Nicholas E. (2006). Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of omega-conotoxin GVIA. Tetrahedron, 62 (31), 7284-7292. doi: 10.1016/j.tet.2006.05.041

Schroeder, C. I. and Lewis, R. J. (2006). Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential. Marine Drugs, 4 (3), 193-214. doi: 10.3390/md403193

Ragnarsson, L., Yasuda, T., Lewis, R. J., Dodd, P. R. and Adams, D. J. (2006). NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G. Journal of Neurochemistry, 96 (1), 283-291. doi: 10.1111/j.1471-4159.2005.03574.x

Dutertre, S., Lumsden, N. G., Alewood, P. F. and Lewis, R. J. (2006). Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. Febs Letters, 580 (16), 3860-3866. doi: 10.1016/j.febslet.2006.06.011

Lewis, R. J. (2006). Ciguatera: Australian perspectives on a global problem. Toxicon, 48 (7), 799-809. doi: 10.1016/j.toxicon.2006.07.019

Nicholson, Graham M. and Lewis, Richard J. (2006). Ciguatoxins: Cyclic polyether modulators of voltage-gated Iion channel function. Marine Drugs, 4 (3), 82-118. doi: 10.3390/md403082

Sauviat, Martin-Pierre, Boydron-Le Garrec, Raphaële, Masson, Jean-Baptiste, Lewis, Richard L., Vernoux, Jean-Paul, Molgo, Jordi, Laurent, Dominique and Benoit, Evelyne (2006). Mechanisms involved in the swelling of erythrocytes caused by Pacific and Caribbean ciguatoxins. Blood Cells Molecules And Diseases, 36 (1), 1-9. doi: 10.1016/j.bcmd.2005.10.007

Dutertre, S. and Lewis, R. J. (2006). Toxin insights into nicotinic acetylcholine receptors. Biochemical Pharmacology, 75 (6), 661-670. doi: 10.1016/j.bcp.2006.03.027

Nielsen, Carsten K., Lewis, Richard J., Alewood, Dianne, Drinkwater, Roger, Palant, Elka, Patterson, Margaret, Yaksh, Tony L, McCumber, Damon and Smith, Maree T. (2005). Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain, 118 (1-2), 112-124. doi: 10.1016/j.pain.2005.08.002

Birinyi-Strachan, Liesl C., Davies, Michael J., Lewis, Richard J. and Nicholson, Graham M. (2005). Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: A comparison with other osmotic agents and free radical scavengers. Neuropharmacology, 49 (5), 669-686. doi: 10.1016/j.neuropharm.2005.04.024

Lima, Vanessa, Mueller, André, Kamikihara, Susana Y., Raymundi, Vanessa, Alewood, Dianne, Lewis, Richard J., Chen, Zhongjian, Minneman, Kenneth P. and Pupo, André S. (2005). Differential antagonism by conotoxin p-TIA of contractions mediated by distinct alpha(1)-adrenoceptor subtypes in rat vas deferens, spleen and aorta. European Journal of Pharmacology, 508 (1-3), 183-192. doi: 10.1016/j.ejphar.2004.12.011

Nilsson, K. P. R., Lovelace, E. S., Caesar, C. E., Tynngard, N., Alewood, P. F., Johansson, H. M., Sharpe, I. A., Lewis, R. J., Daly, N. L. and Craik, D. J. (2005). Solution structure of χ-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers, 80 (6), 815-823. doi: 10.1002/bip.20302

Dutertre, S., Nicke, A. and Lewis, R. J. (2005). beta 2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. Journal of Biological Chemistry, 280 (34), 30460-30468. doi: 10.1074/jbc.M504229200

Tsai, V. W. W., Dodd, P. R. and Lewis, R. J. (2005). The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor. Neuroscience, 130 (2), 457-464. doi: 10.1016/j.neuroscience.2004.09.039

Birinyi-Strachan, L. C., Gunning, S. J., Lewis, R. J. and Nicholson, G. M. (2005). Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons. Toxicology And Applied Pharmacology, 204 (2), 175-186. doi: 10.1016/j.taap.2004.08.020

Garrec, R. B. L., Benoit, E., Sauviat, M. P., Lewis, R. J., Molgo, J. and Laurent, D (2005). Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators. Toxicon, 46 (6), 625-634. doi: 10.1016/j.toxicon.2005.07.002

Delumeau, Olivier, Dutta, Sujit, Brigulla, Matthias, Kuhnke, Grit, Hardwick, Steven W., Völker, Uwe, Yudkin, Michael D. and Lewis, Richard J. (2004). Functional and structural characterization of RsbU, a stress signaling protein phosphatase 2C. Journal of Biological Chemistry, 279 (39), 40927-40937. doi: 10.1074/jbc.M405464200

Tsai, Vicky W. -W., Scott, Heather L., Lewis, Richard J. and Dodd, Peter R. (2004). The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in alzheimer’s disease. Neurotoxicity Research, 7 (1-2), 125-141. doi: 10.1007/BF03033782

Chen, Zhongjian, Rogge, George, Hague, Chris, Alewood, Dianne, Colless, Barbara, Lewis, Richard J. and Minneman, Kenneth P. (2004). Subtype-selective noncompetitive or competitive inhibition of human alpha(1)-adrenergic receptors by rho-TIA. Journal of Biological Chemistry, 279 (34), 35326-35333. doi: 10.1074/jbc.M403703200

Mould, J., Yasuda, T., Schroeder, C. I., Beedle, A. M., Doering, C. J., Zamponi, G. W., Adams, D. J. and Lewis, R. J. (2004). The alpha(2)delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Ca(v)2.2) calcium channels. Journal of Biological Chemistry, 279 (33), 34705-34714. doi: 10.1074/jbc.M310848200

Yasuda, T., Chen, L., Barr, W., McRory, J. E., Lewis, R. J., Adams, D. J. and Zamponi, G. W. (2004). Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. European Journal of Neuroscience, 20 (1), 1-13. doi: 10.1111/j.1460-9568.2004.03434.x

Dutertre, Sébastien and Lewis, Richard J. (2004). Computational approaches to understand alpha-conotoxin interactions at neuronal nicotinic receptors. European Journal of Biochemistry, 271 (12), 2327-2334. doi: 10.1111/j.1432-1033.2004.04147.x

Kloda, A., Clements, J. D., Lewis, R. J. and Adams, D. J. (2004). Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors. Molecular Pharmacology, 65 (6), 1386-1396. doi: 10.1124/mol.65.6.1386

Dodd, P., Tsai, V. and Lewis, R. (2004). The role of metabotropic glutamate receptors in glutamate-induced neuronal excitotoxicity in Alzheimers disease. Journal of Neurochemistry, 88 (Supplement 1)

Yasuda, T., Lewis, R. J. and Adams, D. J. (2004). Overexpressed Ca-v beta 3 inhibits N-type (Ca(v)2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow" and "closed-state" inactivation. Journal of General Physiology, 123 (4), 401-416. doi: 10.1085/jgp.200308967

Schroeder, I.C., Smythe, M. L. and Lewis, R. J. (2004). Development of small molecules that mimic the binding of w-conotoxins at the N-type voltage-gated calcium channel. Molecular Diversity, 8 (2), 127-134. doi: 10.1023/B:MODI.0000025656.79632.86

Loughnan, M. L., Nicke, A., Jones, A., Adams, D. J., Alewood, P. F. and Lewis, R. J. (2004). Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. Journal of Medicinal Chemistry, 47 (5), 1234-1241. doi: 10.1021/jm031010o

Lewis, R. J. (2004). Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters. Iubmb Life, 56 (2), 89-93. doi: 10.1080/15216540410001668055

Morris, Judy L., Ozols, Daina I., Lewis, Richard J., Gibbins, Ian L. and Jobling, Phillip (2004). Differential involvement of N-type calcium channels in transmitter release from vasoconstrictor and vasodilator neurons. British Journal of Pharmacology, 141 (6), 961-970. doi: 10.1038/sj.bjp.0705712

Baell, J. B., Duggan, P. J., Forsyth, S. A., Lewis, R. J., Lok, Y. P. and Schroeder, C. I. (2004). Synthesis and biological evaluation of nonpeptide mimetics of co-conotoxin GVIA. Bioorganic & Medicinal Chemistry, 12 (15), 4025-4037. doi: 10.1016/j.bmc.2004.05.040

Nicke, A, Samochocki, M, Loughnan, ML, Bansal, PS, Maelicke, A and Lewis, RJ (2004). alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors (vol 554, pg 219, 2003). Febs Letters, 557 (1-3), 294-294. doi: 10.1016/S0014-5793(03)01497-2

Ashcroft, F., Benos, D., Bezanilla, F., Chien, K., Choe, S., Clapham, D., Dougherty, D., Lazdunski, M., Levitan, I., Lewis, R. J., Liss, B., Lummis, S., Miller, C. W., North, A., Peters, J., Sanguinetti, M., Smart, T., Stuhmer, W., Vandenberg, J. I. and Verkman, A. (2004). Twenty questions: Highlighting the pitfalls and possibilities of drug research. Nature Review Drug Discovery Research, 3 (3), 238.

Dutertre, Sébastien, Nicke, Annette, Tyndall, Joel D. A. and Lewis, Richard J. (2004). Determination of alpha-conotoxin binding modes on neuronal nicotinic acetylcholine receptors. Journal of Molecular Recognition, 17 (4), 339-347. doi: 10.1002/jmr.683

Daly, N. L., Ekberg, J. A., Thomas, L., Adams, D. J., Lewis, R. J. and Craik, D. J. (2004). Structures of mu O-conotoxins from Conus marmoreus - Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. Journal of Biological Chemistry, 279 (24), 25774-25782. doi: 10.1074/jbc.M313002200

Jobling, P., Gibbins, I. L., Lewis, R. J. and Morris, J. L. (2004). Differential expression of calcium channels in sympathetic and parasympathetic preganglionic inputs to neurons in paracervical ganglia of guinea-pigs. Neuroscience, 127 (2), 455-466. doi: 10.1016/j.neuroscience.2004.05.005

Nicke, Annette C., Wonnacott, Susan and Lewis, Richard J. (2004). alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes. European journal of biochemistry, 271 (12), 2305-2319. doi: 10.1111/j.1432-1033.2004.04145.x

Nicke, Annette, Samochocki, Marek, Loughnan, Marion L., Bansal, Paramjit S., Maelicke, Alfred and Lewis, Richard J. (2003). alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors. Febs Letters, 554 (1-2), 219-223. doi: 10.1016/S0014-5793(03)01161-X

Pottier, I., Hamilton, B., Jones, A., Lewis, R. J. and Vernoux, J. P. (2003). Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding. Toxicon, 42 (6), 663-672. doi: 10.1016/j.toxicon.2003.09.004

Sharpe, Iain A., Palant, Elka, Schroeder, Christina I., Kaye, David M., Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2003). Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship. Journal of Biological Chemistry, 278 (41), 40317-40323. doi: 10.1074/jbc.M213030200

Bryan-Lluka, Lesley J., Bonisch, Heinz and Lewis, Richard J. (2003). χ-conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter. Journal of Biological Chemistry, 278 (41), 40324-40329. doi: 10.1074/jbc.M213101200

Sharpe, I. A., Thomas, L., Loughnan, M., Motin, L., Palant, E., Croker, D. E., Alewood, D., Chen, S., Graham, R. M., Alewood, P. F., Adams, D. J. and Lewis, R. J. (2003). Allosteric α1 adrenoceptor antagonism by the conopeptide ρ-TIA. Journal of Biological Chemistry, 278 (36), 34451-34457. doi: 10.1074/jbc.M305410200

Blanchfield, J. T., Dutton, J. T., Hogg, R. C., Gallagher, O. P., Craik, D. J., Jones, A., Adams, D. J., Lewis, R. J., Alewood, P. F. and Toth, I. (2003). Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII. Journal of Medicinal Chemistry, 46 (7), 1266-1272. doi: 10.1021/jm020426j

Nicke, Annette, Loughnan, Marion L., Millard, Emma L., Alewood, Paul F., Adams, David J., Daly, Norelle L., Craik, David J. and Lewis, Richard J. (2003). Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. Journal of Biological Chemistry, 278 (5), 3137-3144. doi: 10.1074/jbc.M210280200

Adams, David J., Smith, Amanda B, Schroeder, Christina. I., Yasuda, Takahir and Lewis, Richard J. (2003). ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. Journal of Biological Chemistry, 278 (6), 4057-4062. doi: 10.1074/jbc.M209969200

Marshall, J. A., Nichols, P. D., Hamilton, B., Lewis, R. J. and Hallegraeff, G. M. (2003). Ichthyotoxicity of Chattonella marina (Raphidophyceae) to damselfish (Acanthochromis polycanthus): the synergistic role of reactive oxygen species and free fatty acids. Harmful Algae, 2 (4), 273-281. doi: 10.1016/S1568-9883(03)00046-5

Lewis, R. J. and Garcia, M. L. (2003). Therapeutic potential of venom peptides. Nature Reviews Drug Discovery, 2 (10) 114207, 790-802. doi: 10.1038/nrd1197

Milne, T. J., Abbenante, G., Tyndall, J. D. A., Halliday, J. and Lewis, R. J. (2003). Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. Journal of Biological Chemistry, 278 (33), 31105-31110. doi: 10.1074/jbc.M304843200

Nielsen, K. J., Watson, M., Adams, D. J., Hammarström, A. K., Gage, P. W., Hill, J. M., Craik, D. J., Thomas, L., Adams, D., Alewood, P. F. and Lewis, R. J. (2002). Solution Structure of µ-Conotoxin PIIIA, a Preferential Inhibitor of Persistent Tetrodotoxin-sensitive Sodium Channels. Journal of Biological Chemistry, 277 (30), 27247-27255. doi: 10.1074/jbc.M201611200

Pottier, Ivannah, Vernoux, Jean-Paul, Jones, Alun and Lewis, Richard J. (2002). Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack (Caranx latus) by high-performance liquid chromatography/mass spectrometry. Toxicon, 40 (7) 1715, 929-939. doi: 10.1016/S0041-0101(02)00088-0

Smith, M. T., Cabot, P. J., Ross, F. B., Robertson, A. D. and Lewis, R. J. (2002). The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.. Pain, 96 (1-2), 119-127. doi: 10.1016/S0304-3959(01)00436-5

Hogg, R. C., Lewis, R. J. and Adams, D. J. (2002). Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons. European Journal of Neuroscience, 16 (2), 242-248. doi: 10.1046/j.1460-9568.2002.02071.x

Hamilton, B., Hurbungs, M., Vernoux, J. P., Jones, A. and Lewis, R. J. (2002). Isolation and characterisation of Indian Ocean ciguatoxin. Toxicon, 40 (6), 685-693. doi: 10.1016/S0041-0101(01)00259-8

Ragnarsson, L., Mortensen, M., Dodd, P. R. and Lewis, R. J. (2002). Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex. Journal of Neurochemistry, 81 (4), 765-779. doi: 10.1046/j.1471-4159.2002.00872.x

Pottier, I., Vernoux, J. P., Jones, A. and Lewis, R. J. (2002). Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies. Food Additives And Contaminants, 19 (11), 1034-1042. doi: 10.1080/02652030210155378

Hamilton, B., Hurbungs, M., Jones, A. and Lewis, R. J. (2002). Multiple ciguatoxins present in Indian Ocean reef fish. Toxicon, 40 (9), 1347-1353. doi: 10.1016/S0041-0101(02)00146-0

Blanchfield, Joanne T., Dutton, Julie T., Hogg, R. C., Craik, D. J., Adams, D. J., Lewis, R. J., Alewood, P. and Toth, I. (2001). The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII. Letters in Peptide Science, 8 (3-5), 235-239. doi: 10.1023/A:1016577832311

Pottier, I., Vernoux, J. P. and Lewis, R. J. (2001). Ciguatera fish poisoning in the Caribbean islands and western Atlantic. Reviews of Environmental Contamination And Toxicolgy, 168, 99-141. doi: 10.1007/978-1-4613-0143-1_3

Sharpe, I. A., Gehrmann, J., Loughnan, M. L., Thomas, L., Adams, D. A., Atkins, A., Palant, E., Craik, D. J., Adams, D. J., Alewood, P. F. and Lewis, R. J. (2001). Two new classes of conopeptides inhibit the alpha 1-adrenoceptor and noradrenaline transporter. Nature Neuroscience, 4 (9), 902-907. doi: 10.1038/nn0901-902

Lewis, R. J. (2001). The changing face of ciguatera. Toxicon, 39 (1), 97-106. doi: 10.1016/S0041-0101(00)00161-6

Lewis, R. J. (2000). Ion channel toxins and therapeutics: From cone snail venoms to ciguatera.. Therapeutic Drug Monitoring, 22 (1), 61-64. doi: 10.1097/00007691-200002000-00013

Lehane, L. and Lewis, R. J. (2000). Ciguatera:Recent advances but the risk remains. International Journal of Food Microbiology, 61 (2-3), 91-125. doi: 10.1016/S0168-1605(00)00382-2

Nielsen, K. J., Schroeder, T. and Lewis, R. J. (2000). Structure-activity relationships of w-conotoxins at N-type voltage-sensitive calcium channels. Journal of Molecular Recognition, 13 (2), 55-70. doi: 10.1002/(SICI)1099-1352(200003/04)13:2<55::AID-JMR488>3.0.CO;2-O

Hill, J. M., Atkins, A. R., Loughnan, M. L., Jones, A., Adams, D. A., Martin, R. C., Lewis, R. J., Craik, D. J. and Alewood, P. F. (2000). Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa - 1. Isolation, characterization and chemical synthesis. European Journal of Biochemistry, 267 (15), 4642-4648. doi: 10.1046/j.1432-1327.2000.01508.x

Lewis, Richard J., Nielsen, Katherine J., Craik, David J., Loughnan, Marion L., Adams, Denise A., Sharpe, Iain A., Luchian, Tudor, Adams, David J., Bond, Trudy, Thomas, Linda, Jones, Alun, Matheson, Jodi-Lea, Drinkwater, Roger, Andrews, Peter R. and Alewood, Paul F. (2000). Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. Journal of Biological Chemistry, 275 (45), 35335-35344. doi: 10.1074/jbc.M002252200

Hogg, Ron C., Miranda, Les P., Craik, David J., Lewis, Richard J., Alewood, Paul F. and Adams, David J. (1999). Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor. Journal of Biological Chemistry, 274 (51), 36559-36564. doi: 10.1074/jbc.274.51.36559

Nielsen, Katherine J., Adams, Denise A., Alewood, Paul F., Lewis, Richard J., Thomas, Linda, Schroeder, Tina and Craik, David J. (1999). Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus. Biochemistry, 38 (21), 6741-6751. doi: 10.1021/bi982980u

Nielsen, Katherine J., Skjaerbaek, Niels, Dooley, Michael, Adams, Denise A., Mortensen, Martin, Dodd, Peter R., Craik, David J., Alewood, Paul F. and Lewis, Richard J. (1999). Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators. Journal of Medicinal Chemistry, 42 (3), 415-426. doi: 10.1021/jm981052q

Lewis, R., Jones, A. and Vernoux, J. (1999). HPLC/Tandem Electrospray Mass Spectrometry for the Determination of Sub-ppb Levels of Pacific and Caribbean Ciguatoxins in Crude Extracts of Fish. Analytical Chemistry, 71 (1), 247-250. doi: 10.1021/ac980598h

Eriksson, Ludvig, Guy, Sharon, Perlmutter, Patrick and Lewis, Richard (1999). A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C. Journal of Organic Chemistry, 64 (22), 8396-8398. doi: 10.1021/jo990389c

Adams, D. J., Alewood, P. F., Craik, D. J., Drinkwater, R. D. and Lewis, R. J. (1999). Conotoxins and their potential pharmaceutical applications. Drug Development Research, 46 (3-4 Special Issue: Biotechnology and Pharmacology in Australia), 219-234. doi: 10.1002/(SICI)1098-2299(199903/04)46:3/4<219::AID-DDR7>3.0.CO;2-S

Nielsen, Katherine J., Adams, Denise, Thomas, Linda, Bond, Trudy, Alewood, Paul F., Craik, David J. and Lewis, Richard J. (1999). Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. Journal of Molecular Biology, 289 (5), 1405-1421. doi: 10.1006/jmbi.1999.2817

Strachan, Liesl C., Lewis, Richard J. and Nicholson, Graham M. (1999). Differential Actions of Pacific Ciguatoxin-1 on Sodium Channel Subtypes in Mammalian Sensory Neurons. The Journal of Pharmacology and Experimental Therapeautics, 288 (1), 379-388.

Hu, Shu-Hong, Loughnan, M., Miller, R., Weeks, C.M., Blessing, R.H., Alewood, P.F., Lewis, R.J. and Martin, J.L. (1998). The 1.1 angstrom resolution crystal structure of [Tyr15]EpI, a novel α-conotoxin from Conus episcopatus, solved by direct methods. Biochemistry, 37 (33), 11425-11433. doi: 10.1021/bi9806549

Hogg, R. C., Lewis, R. J. and Adams, D. J. (1998). Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones. Neuroscience Letters, 252 (2), 103-106. doi: 10.1016/S0304-3940(98)00575-8

Loughnan, Marion, Bond, Trudy, Atkins, Anne, Cuevas, Javier, Adams, David J., Broxton, Natalie M., Livett, Bruce G., Down, John G., Jones, Alun, Alewood, Paul F. and Lewis, Richard J. (1998). alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors. Journal of Biological Chemistry, 273 (25), 15667-15674. doi: 10.1074/jbc.273.25.15667

Moore, MR, Ng, JC and Lewis, RJ (1998). Environmental poisoning: Presentation and management. Therapeutic Drug Monitoring, 20 (5), 502-509. doi: 10.1097/00007691-199810000-00010

Lewis, RJ, Vernoux, JP and Brereton, IM (1998). Structure of Caribbean ciguatoxin isolated from Caranx latus. Journal of The American Chemical Society, 120 (24), 5914-5920. doi: 10.1021/ja980389e

Vernoux, JP and Lewis, RJ (1997). Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus). Toxicon, 35 (6), 889-900. doi: 10.1016/S0041-0101(96)00191-2

Poli, MA, Lewis, RJ, Dickey, RW, Musser, SM, Buckner, CA and Carpenter, LG (1997). Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among US soldiers in Haiti. Toxicon, 35 (5), 733-741. doi: 10.1016/S0041-0101(96)00166-3

Fenner, PJ, Lewis, RJ, Williamson, JA and Williams, ML (1997). A Queensland family with ciguatera after eating coral trout. Medical Journal of Australia, 166 (9), 473-475. doi: 10.5694/j.1326-5377.1997.tb123219.x

Lewis, RJ and Jones, A (1997). Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography mass spectrometry. Toxicon, 35 (2), 159-168. doi: 10.1016/S0041-0101(96)00132-8

Scanlon, MJ, Naranjo, D, Thomas, L, Alewood, PF, Lewis, RJ and Craik, DJ (1997). Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA. Structure, 5 (12), 1585-1597. doi: 10.1016/S0969-2126(97)00307-9

Skjaerbaek, N, Nielsen, KJ, Lewis, RJ, Alewood, P and Craik, DJ (1997). Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy. Journal of Biological Chemistry, 272 (4), 2291-2299. doi: 10.1074/jbc.272.4.2291

Lucas R.E., Lewis R.J. and Taylor J.M. (1997). Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in East Arnhem Land, Australia. Natural Toxins, 5 (4), 136-140. doi: 10.1002/19970504NT2

Nielsen, KJ, Thomas, L, Lewis, RJ, Alewood, PF and Craik, DJ (1996). A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: Comparison of MVIIA, SVIB and SNX-202. Journal of Molecular Biology, 263 (2), 297-310. doi: 10.1006/jmbi.1996.0576

Lewis R., Alewood P., Dooley M., Martin J., Drinkwater R., Craik D. and Andrews P. (1996). Secrets of the cone shell. Today's Life Science, 8 (8), 16-18+20+22+24.

Lau, CO, Tan, CH, Khoo, HE, Yuen, R, Lewis, RJ, Corpuz, GP and Bignami, GS (1995). Lophozozymus Pictor Toxin - a Fluorescent Structural Isomer of Palytoxin. Toxicon, 33 (10), 1373-1377. doi: 10.1016/0041-0101(95)00075-W

Brock, JA, McLachlan, EM, Jobling, P and Lewis, RJ (1995). Electrical-Activity in Rat Tail Artery During Asynchronous Activation of Postganglionic Nerve-Terminals by Ciguatoxin-1. British Journal of Pharmacology, 116 (4), 2213-2220. doi: 10.1111/j.1476-5381.1995.tb15056.x

Hamblin, PA, McLachlan, EM and Lewis, RJ (1995). Sub Nanomolar Concentrations of Ciguatoxin-1 Excite Preganglionic Terminals in Guinea-Pig Sympathetic-Ganglia. Naunyn-Schmiedebergs Archives of Pharmacology, 352 (2), 236-246. doi: 10.1007/BF00176780

Manger, RL, Leja, LS, Lee, SY, Hungerford, JM, Hokama, Y, Dickey, RW, Granade, HR, Lewis, R, Yasumoto, T and Wekell, MM (1995). Detection of Sodium-Channel Toxins - Directed Cytotoxicity Assays of Purified Ciguatoxins, Brevetoxins, Saxitoxins, and Seafood Extracts. Journal of Aoac International, 78 (2), 521-527.

Holmes M.J., Lewis R.J., Jones A. and Hoy A.W.W. (1995). Cooliatoxin, the first toxin from Coolia monotis (dinophyceae). Natural Toxins, 3 (5), 355-362. doi: 10.1002/nt.2620030506

Pearn, John H. and Lewis, R. (1994). Ciguatera: Risk perception and fish ingestion. Memoirs of the Queensland Museum, 34 (3), 605-6068.

Lewis R.J., Bingham J.P., Jones A., Alewood P.F. and Andrews P.R. (1994). Drugs from the peptide venoms of marine cone shells.. Australasian biotechnology, 4 (5), 298-300.

Lewis, R. J. (1994). Ciguatera and herbivores: uptake and accumulation of ciguatoxins in Ctenochaetus striatus on the Great Barrier Reef. Memoirs - Queensland Museum, 34 (3), 565-570.

Lewis, R. J., Holmes, M. J. and Sellin, M. (1994). Invertebrates implicated in the transfer of gambiertoxins to the benthic carnivore Pomadasys maculatus. Memoirs - Queensland Museum, 34 (3), 561-564.

Holmes, M. J., Lewis, R. J., Sellin, M. and Street, R. (1994). The origin of ciguatera in Platypus Bay, Australia. Memoirs - Queensland Museum, 34 (3), 505-512.

Lewis R.J., Holmes M.J., Alewood P.F. and Jones A. (1994). Lonspray mass spectrometry of ciguatoxin‐1, maitotoxin‐2 and ‐3, and related marine polyether toxins. Natural Toxins, 2 (2), 56-63. doi: 10.1002/nt.2620020203

Holmes, Michael J. and Lewis, Richard J. (1994). Purification and characterisation of large and small maitotoxins from cultured gambierdiscus toxicus. Natural Toxins, 2 (2), 64-72. doi: 10.1002/nt.2620020204

Lewis, RJ and Holmes, MJ (1993). Origin and Transfer of Toxins Involved in Ciguatera. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology, 106 (3), 615-628. doi: 10.1016/0742-8413(93)90217-9

Lewis, RJ and Sellin, M (1993). Recovery of Ciguatoxin From Fish Flesh. Toxicon, 31 (10), 1333-1336. doi: 10.1016/0041-0101(93)90407-A

Lewis, RJ, Hoy, Aww and Sellin, M (1993). Ciguatera and Mannitol - In-Vivo and In-Vitro Assessment in Mice. Toxicon, 31 (8), 1039-1050. doi: 10.1016/0041-0101(93)90262-H

Lewis, RJ, Norton, RS, Brereton, IM and Eccles, CD (1993). Ciguatoxin-2 Is a Diastereomer of Ciguatoxin-3. Toxicon, 31 (5), 637-643. doi: 10.1016/0041-0101(93)90118-3

Lewis, RJ and Hoy, Aww (1993). Comparative Action of 3 Major Ciguatoxins On Guinea-Pig Atria and Ilea. Toxicon, 31 (4), 437-446. doi: 10.1016/0041-0101(93)90179-M

LEWIS, RJ and RUFF, TA (1993). CIGUATERA - ECOLOGICAL, CLINICAL, AND SOCIOECONOMIC PERSPECTIVES. Critical Reviews in Environmental Science and Technology, 23 (2), 137-156. doi: 10.1080/10643389309388447

Dickey, R. W., Bencsath, F. A., Granade, H. R. and Lewis, R. J. (1992). Liquid chromatographic mass spectrometric methods for the determination of marine polyether toxins. Bulletin de la Societe de pathologie exotique (1990), 85 (5 Pt 2), 514-515.

Lewis, R. J. (1992). Socioeconomic impacts and management ciguatera in the Pacific. Bulletin de la Societe de pathologie exotique (1990), 85 (5 Pt 2), 427-434.

Lewis, RJ and Sellin, M (1992). Multiple Ciguatoxins in the Flesh of Fish. Toxicon, 30 (8), 915-919. doi: 10.1016/0041-0101(92)90390-Q

Lewis, RJ, Hoy, Aww and McGiffin, DC (1992). Action of Ciguatoxin On Human Atrial Trabeculae. Toxicon, 30 (8), 907-914. doi: 10.1016/0041-0101(92)90389-M

Lewis, RJ (1992). Ciguatoxins Are Potent Ichthyotoxins. Toxicon, 30 (2), 207-211. doi: 10.1016/0041-0101(92)90474-J

Lewis, RJ, Sellin, M, Poli, MA, Norton, RS, Macleod, JK and Sheil, MM (1991). Purification and Characterization of Ciguatoxins From Moray Eel (Lycodontis-Javanicus, Muraenidae). Toxicon, 29 (9), 1115-1127. doi: 10.1016/0041-0101(91)90209-A

Holmes, MJ, Lewis, RJ, Poli, MA and Gillespie, NC (1991). Strain Dependent Production of Ciguatoxin Precursors (Gambiertoxins) by Gambierdiscus-Toxicus (Dinophyceae) in Culture. Toxicon, 29 (6), 761-775. doi: 10.1016/0041-0101(91)90068-3

Holmes, MJ, Lewis, RJ and Gillespie, NC (1990). Toxicity of Australian and French-Polynesian Strains of Gambierdiscus-Toxicus (Dinophyceae) Grown in Culture - Characterization of a New Type of Maitotoxin. Toxicon, 28 (10), 1159-1172. doi: 10.1016/0041-0101(90)90116-O

Pearn, J.H., Lewis, R.J., Ruff, T., Tait, M., Quinn, J., Murtha, W., King, G., Mallett, A. and Gillespie, N.C. (1989). Ciguatera and mannitol: experience with a new treatment regimen. Medical Journal of Australia, 151 (2), 77-80.

Lewis, RJ (1988). Negative Inotropic and Arrhythmic Effects of High-Doses of Ciguatoxin On Guinea-Pig Atria and Papillary-Muscles. Toxicon, 26 (7), 639-649. doi: 10.1016/0041-0101(88)90246-2

Gillespie, N.C., Lewis, R.J., Pearn, J.H., Bourke, A.T.C., Holmes, M.J., Bourke, J.B. and Shields, W.J. (1986). Ciguatera in Australia - occurrence, clinical-features, pathophysiology and management. Medical Journal of Australia, 145 (11-12), 584-590.

Lewis, RJ and Endean, R (1986). Direct and Indirect Effects of Ciguatoxin On Guinea-Pig Atria and Papillary-Muscles. Naunyn-Schmiedebergs Archives of Pharmacology, 334 (3), 313-322. doi: 10.1007/BF00508787

Lewis, RJ and Endean, R (1984). Mode of Action of Ciguatoxin From the Spanish Mackerel, Scomberomorus-Commersoni, On the Guinea-Pig Ileum and Vasdeferens. Journal of Pharmacology and Experimental Therapeutics, 228 (3), 756-760.

Lewis, RJ and Endean, R (1984). Ciguatoxin From the Flesh and Viscera of the Barracuda, Sphyraena-Jello. Toxicon, 22 (5), 805-810. doi: 10.1016/0041-0101(84)90163-6

Lewis R.J. and Endean R. (1983). Purification of ciguatoxin-like material from Scomberomorus commersoni and its effect on the rat phrenic nerve-diaphragm. Toxicon, 21 (SUPPL. 3), 249-252. doi: 10.1016/0041-0101(83)90201-5

Endean R., Lewis R., Gyr P. and Williamson J. (1983). Toxic material from the crab Atergatis floridus. Toxicon, 21 (SUPPL. 3), 111-113. doi: 10.1016/0041-0101(83)90167-8

Lewis, RJ and Endean, R (1983). Occurrence of a Ciguatoxin-Like Substance in the Spanish Mackerel (Scomberomorus-Commersoni). Toxicon, 21 (1), 19-24. doi: 10.1016/0041-0101(83)90045-4

Cameron A.M., Wong Hoy A.W. and Lewis R.J. (1983). The effects of two stonefish skin toxins on guinea-pig atria. Toxicon, 21 (SUPPL. 3), 53-56. doi: 10.1016/0041-0101(83)90153-8

Cameron, AM and Lewis, RJ (1982). The Antispasmogenic Action On Guinea-Pig Ileum of a Fraction Obtained From the Toxic Skin Secretion of the Stonefish, Synanceia-Trachynis. Toxicon, 20 (6), 991-1000. doi: 10.1016/0041-0101(82)90101-5

Pearn, J., Harvey, P., Deambrosis, W., Lewis, R. and McKay, R. (1982). Ciguatera and pregnancy. Medical Journal of Australia, 1 (2), 57-58.

Cameron, AM, Surridge, J, Stablum, W and Lewis, RJ (1981). A Crinotoxin From the Skin Tubercle Glands of a Stonefish (Synanceia-Trachynis). Toxicon, 19 (1), 159-170. doi: 10.1016/0041-0101(81)90128-8

Zhao, Tianjiao, Rosengren, Johan K., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Structure-function of the spider peptide ProTx-III. Venom to Drugs, Daydream Island, QLD Australia, 15-19 March 2021.

Dongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Characterization and structure-function of a novel spider-venom toxin Phlo3a at hNav1.2, 1.3 and 1.7. Venom to Drugs, Daydream Island, QLD, Australia, 15-19 March 2021.

Hasan, Mahadhi, Abraham, Nikita, Cardoso, Fernanda C., Ragnarsson, Lotten, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2. Venom to Drugs, Daydream Island, QLD Australia, 15 - 19 March 2021.

Dongol, Y., Choi, P., Wilson, D., Cardoso, F. C. and Lewis, R. J. (2020). Rationally Designed Analogues of the Novel Spider-venom Peptide Phlo3a Shifts the Potency and Subtype Selectivity at Therapeutic Nav Channel Targets for Pain and Epilepsy. SBMS Postgraduate Symposium in Biomedical Sciences, Brisbane, QLD Australia, 24 November 2020.

Fernandez-Rojo, Manuel A., Brust, Andreas, Potriquet, Jeremy, Daley, Joshua, Ragnarsson, Lotten, Andersson, Asa, Mukhopadhyay, Pamela, Wilhelm, Patrick, Chin, Yanni, Smallwood, Taylor, Clark, Richard, King, Glenn, Ramm, Grant, Waddell, Nic, Lewis, Richard, Boyle, Glen, Fry, Bryan, Alewood, Paul, Mulvenna, Jason, Miles, John and Ikonomopoulou, Maria P. (2020). The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.014

Dutt, Mriga, Giacomotto, Jean, Ragnarsson, Lotten, Andersson, Asa, Brust, Andreas, Deakan, Zoltan, Alewood, Paul F. and Lewis, Richard J. (2020). Re-evaluating the nirvana cabal deployed by piscivorous cone snails. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.044

Hu, Huyiu, Lewis, Richard J. and Cardoso, Fernanda C. (2019). Molecular interactions between spider toxins and the sodium channel Nav1.1. Pain Retreat 2019, Stradbroke Island, QLD Australia, 27-29 May 2019.

Hasan, Mahadhi, Mueller, Alexander, Starobova, Hana, Vetter, Irina, Cardoso, Fernanda C. and Lewis, Richard J. (2019). New insights in ω-conotoxin analgesic efficacy in postsurgical pain and oxaliplatin/cisplatin induced peripheral neuropathy. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.

Mawlawi, Saja E., Zhao, Thianjiao, Lewis, Richard J. and Cardoso, Fernanda C. (2019). Cooperative interactions of loops 1, 4 and C-terminal of the ICK spider peptide Tap1a engender NaV inhibitory properties. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.

Zhao, Tianjiao, Rosengren, K. Johan, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.

Cardoso, Fernanda C., King, Glenn F. and Lewis, R. J. (2019). Discovery of novel cav and nav modulators in spider venoms and applications in the development of drugs to treat chronic pain. 19th World Congress of the International Society on Toxinology, Haikou City, Hainan Province, China, 24-31 October 2017. Oxford, United Kingdom: Elsevier.

Wang, Dan, Himaya, S. W. A., Giacomotto, Jean, Hasan, Mahadhi, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Characterization of δ-conotoxin Tx-VIA as selective T-type modulator. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD, Australia, 29 November 2019.

Dongol, Y., Cardoso, F. C. and Lewis, R. J. (2018). Can Phlo3a – a newly discovered spider knottin – meets the challenges to strategically modulate noxious Nav-channels?. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.

Hasan, M.D., Cardoso, F.C. and Lewis, R.J. (2018). Comparative analysis of transfection methods to establish high-throughput automated electrophysiology assays for key ion channels involved in pain. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.

Ferraz, C. R., Cardos, F. C., Clissa, P. B., Vetter, I., Verri Jr, W. A. and Lewis, R. J. (2018). Jararhagin, a metalloproteinase from Bothrops jararaca venom, induces mechanical and thermal hyperalgesia through TRPV1 channel activation. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.

Cardoso, F. C., Herzig, V., King, G. F. and Lewis, R. J. (2018). Counter screen of spider venoms reveals novel sodium and calcium channel inhibitors of chronic pain targets.. Gordon Research Conference on Venom Evolution, Function and Biomedical Applications 2018, Mount Snow, VT, United States, 5-10 August 2018.

Zhao, T., Cardoso, F.C. and Lewis, R.J. (2018). Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.

L'Herondelle, Killian, Misery, Laurent, Le Gall-Ianotto, Christelle, Philippe, Reginald, Talagas, Matthieu, Mignen, Olivier, Lewis, Richard and Le Garrec, Raphaele (2017). NEW INSIGHTS INTO THE PATHOPHYSIOLOGY OF ITCH DURING CIGUATERA FISH POISONING. UPPSALA: ACTA DERMATO-VENEREOLOGICA.

Wang, D., Herzig, V., Dekan, Z., Ragnarsson, Lotten K. N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). High-throughput cell-based assays for screening Cav3.2 modulators from venoms. Venom to Drugs Conference 2017, Noosa Heads, QLD, Australia, 9-14 October 2017.

Cardoso, Fernanda C., Bellingham, Mark C., King, Glenn F. and Lewis, Richard J. (2017). Nav modulators in spider venoms and applications in the development of novel therapies for neurological disorders. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.

Cardoso, Fernanda C., King, Glenn F. and Lewis, Richard J. (2017). Discovery of novel CaV and NaV modulators in spider venoms and applications in the development of drugs to treat chronic pain.. 19th World Congress of the International Society on Toxinology, Haikou City, Hainan Province, China, 24-31 October 2017.

Hassan, Mahadhi, Abraham, Nikita, Ragnarsson, Lotten K.N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). Defining ω-conotoxin binding site and delineating the role of the α2δ1 subunit in ω-conotoxin binding. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.

L'herondelle, K., Philippe, R., Mignen, O., Vetter, I., Lewis, R. J., Misery, L. and Le Garrec, R. (2016). Study of the involvement of itch mediators in the neuropeptide release induced by Pacific-Ciguatoxin-2 in a co-culture model of sensory neurons and keratinocytes. 22nd Meeting of the French-Society-of-Toxinology (SFET), Paris, France, 10-11 December 2014. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.toxicon.2016.01.007

Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Vetter, Irina, Busnelli, Marta, Chini, Bice, Arrowsmith, Sarah, Wray, Susan, de Araujo, Aline Dantas, Dutertre, Sebastien, Mobli, Mehdi, Lewis, Richard J., Gruber, Christian W. and Alewood, Paul F. (2016). Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Hoboken, NJ United States: Wiley.

Sairaman, Anjali, Cardoso, Fernanda Caldas , Lewis, Richard J., Kaliappana, Krishna P., Tuck, Kellie L. and Duggan, Peter J. (2016). The inhibition of neuronal calcium channels with aminobenzothiazole derivatives. RACI Medicinal Chemistry and Chemical Biology Conference 2016, Coogee Beach, NSW, Australia, 7-9 November 2016.

Cardoso, Fernanda Caldas , Herzig, Volker , King, Glenn F. and Lewis, Richard J. (2015). Harnessing animal venoms in the discovery of potent Nav inhibitors through fluorescent and automated patch clamp assays. 18th World Congress of the International Society on Toxinology, Oxford UK, 25-30 September 2015.

Brust, A., Gori, A., Wang, C-I A., Harvey, P. J., Rosengren, K. J., Gelmi, M. L., Longh, R., Lewis, R. J. and Alewood, P. F. (2014). SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID. 33rd European Peptide Symposium, Sofia, Bulgaria, 31 August – 5 September 2014. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2687

Erickson, A., Cardoso, F. C., Lewis, R. J. and King, G. F. (2014). Optimizing the potency and selectivity of a spider-venom peptide that inhibitis the analgesic target Nav1.7.. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.

Prashanth, J. R., Dutertre, S., Jean, A., Lavergne, V., Hamilton, B., Cardoso, F. C., Griffin, J., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2014). Unique evolution of D-conotoxins for defence. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 August 2014.

Cardoso, F. C., Dekan, Z., Anangi, R., Rosengren, K. J., Erickson, A., Vetter, I., Herzig, V., Alewood, P., King, G. F. and Lewis, R. J. (2014). Discovery of voltage-gated sodium channel inhibitors from tarantula venoms. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.

L'herondelle, K., Philippe, R., Mignen, O., Vetter, I., Lewis, R. J., Misery, L. and Le Garrec, R. (2014). Effets de la ciguatoxine P-CTX-2 sur la liberation induite de neuropeptides dans un modele de co-culture keratinocytes-neurones sensoriels. 32e Congrès Annuel de Recherche Dermatologique (CARD), Océanopolis, Brest, France, 25-27 June, 2014. Issy les Moulineaux, France: Elsevier Masson. doi: 10.1016/j.annder.2014.04.154

Le Garrec, Raphaele, Vetter, Irina, Lewis, Richard J. and Misery, Laurent (2013). Ciguatoxin-Induced Release of Neuropeptides in a Sensory Neuron-Keratinocyte Coculture Model. World Congress on Itch (WCI), Boston, MA United States, 21–23 September 2013. UPPSALA: ACTA DERMATO-VENEREOLOGICA. doi: 10.2340/00015555-1701

Cardoso, F. C., Herzig, V., Hauke, T., Lewis, R. J. and King, G. F. (2013). Discovery of novel spider peptides blocking hNav1.7. 3rd Annual Conference of the Toxinological Society of India and 1st International Conference on “Biology of Natural Toxins”, Goa, India, 19-21 December, 2013.

Prashanth, J. R., Dutertre, S., Lavergne, V., Hamilton, B., Cardoso, F. C., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2013). The injected venom of vermivorous cone snails. 10th Australian Peptides Conference, Penang, Malaysia, 8-13 September 2013.

Cardoso, F. C., Herzig, V., Hauke, T., King, G. F. and Lewis, R. J. (2013). Harnessing high-throughput screening strategies for identification of selective hNav1.7 blockers for the treatment of chronic pain. CASB Division Symposium 2013, Brisbane Australia, 7 November, 2013.

Jin, Ai-hua, Dutertre, Sébastien, Kaas, Quentin, Lewis, Richard J. and Alewood, Paul F. (2012). Transcriptomic and peptidomic characterisation of the Conus marmoreus venom: Insights on conopeptide diversity and venomic processing. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.099

Sousa, Silmara R., Ragnarsson, Lotten, Vetter, Irina, Herzig, Volker, King, Glenn F. and Lewis, Richard J. (2012). Development of high throughput calcium channel assays to accelerate the discovery of novel toxins targeting human cav2.2 channels. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.033

Lewis, Richard J. (2012). Discovery and development of chi-conopeptides for the treatment of pain. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.040

Dutertre, Sébastien, Jin, Ai-hua, Alewood, Paul F. and Lewis, Richard J. (2012). The venom of Conus geographus revisited. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.100

Ragnarsson, Lotten, Wang, Ching-I. Anderson, Andersson, Åsa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2012). The allosteric binding site for rho-TIA on the extracellular surface of the alpha 1B-Adrenoceptor. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.137

Muttenthaler, M., Dawson, P. E., Gruber, C. W., Bergmayr, C., Freissmuth, M., Andersson, A., Vetter, I., Dutertre, S., Lewis, R. J. and Alewood, P. F. (2012). Novel sources for potent and selective GPCR modulators. unknown, unknown, unknown. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2447

Vetter, Irina and Lewis, Richard J. (2011). Accelerated biodiscovery of ion channel modulators. 84th Annual Meeting of the Japanese Pharmacological Society/11th Southeast Asian Western Pacific Regional Meeting of Pharmacologists, Yokohama, Japan, 22-24 March 2011. Kyoto, Japan: Nihon Yakuri Gakkai Henshuubu.

Muttenthaler, M., Gruber, C. W., Andersson, A., Vetter, I., Nevin, S. T., Grishin, A. A., Dutertre, S., Daly, N. L., Craik, D. J., Adams, D. J., Lewis, R. J. and Alewood, P. F. (2011). Conotoxins - blueprints for GPCR drug discovery?. 22nd American Peptide Symposium, San Diego, CA, United States, 25-30 June 2011. Hoboken, NJ, United States: John Wiley & Sons.

Muttenthaler, M. M., de Araujo, A. D., Andersson, A., Vetter, I., Gruber, C., Ramos, Y. Garcia, Feytens, D., Bergmayr, C., Freissmuth, M., Lewis, R. and Alewood, P. (2010). Oxytocin agonist design - A selenocysteine mimetic reveals a functional selectivity switch for the human oxytocin receptor. 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Chichester, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1303

Dekan, Z., Andersson, A. C., Lewis, R. J. and Alewood, P. F. (2010). Replacement of disulfide bonds with ditellurides: Synthesis and biological activity of ditelluro-oxytocin. 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Chichester, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1303

Brust, A., Colless, B., Cousins, M., Day, D., Drinkwater, R., Gouke, R., Hughes, D., Lewis, R. J., Martin, W., Nielson, C., Palant, E., Rauck, R., Schmidt, P., Smith, M. T. and Steams, L. J. (2009). Development of XEN2174 and an escalating safety and tolerability study of intrathecal use in oncology patients. Michal Lebl Peptides Breaking Away, Bloomington, Indiana, U.S.A., 7-12 June, 2009. San Diego, C.A. U.S.A.: American Peptide Society.

Adams, David J., Berecki, Geza, Motin, Leonid, Haythornthwaite, Alison, Lewis, Richard J., Alewood, Paul F. and Christie, Macdonald J. (2009). ANALGESIC omega-CONOTOXINS CVIE AND CVIF SELECTIVELY BLOCK N-TYPE CALCIUM CHANNELS IN A REVERSIBLE AND VOLTAGE-DEPENDENT MANNER. TOKYO: SPRINGER TOKYO.

Martin, W., Lewis, R. J., Palant, E., Brust, A., Colless, B., Schmidt, P., Drinkwater, R., Stearns, L. J., Cousins, M., Gouke, R., Hughes, D., Rauck, R., Day, D., Nielsen, C. K. and Smith, M. T. (2009). DEVELOPMENT OF XEN2174: NON-CLINICAL STUDIES AND AN OPEN-LABEL I/IIa STUDY OF INTRATHECAL USE IN ONCOLOGY PATIENTS WITH MODERATE TO SEVERE PAIN. 21st American Peptide Symposium, Bloomington in, Jun 07-12, 2009. HOBOKEN: JOHN WILEY & SONS INC.

Lewis, R. J., Palant, E., Brust, A., Colless, B., Schmidt, P., Nielsen, C. K., Smith, M. T. and Drinkwater, R. (2008). Development of novel X-conopeptide inhibitors of the norepinephrine transporter with analgesic potential. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August, 2008.

Ulens, Chris, Dutertre, Sebastien, Hopping, Gene, Fish, Alex, Schroeder, Christina, van Elk, Rene, Akdemir, Atilla, de Esch, Iwan, Nicke, Annette, Alewood, Paul, Lewis, Richard, Smit, August B. and Perrakis, Anastassis (2007). Structural studies of AChBP, a soluble nicotinic acetylcholine receptor homolog, in complex with novel ligands. 51st Annual Meeting of the Biophysical Society, Baltimore, MD United States, 3-7 March 2007. Cambridge, United Kingdom: Cell Press.

Paczkowski, FA, Bauman, S, Sharpe, LA, Dutertre, S and Lewis, RJ (2007). A conopeptide view of the norepinephrine transporter (NET), an integral membrane Na+- and CI-dependent transporter.. 51st Annual Meeting of the Biophysical Society, Baltimore, 3-7 March 2007. Bethesda: Biophysical Society.

Croker, Daniel, Dutertre, Sebastien, Alewood, Paul and Lewis, Richard (2006). Discovery and pharmacology of conopressin-T, a novel vasopressin-like peptide from Conus tulipa.. OXFORD: BLACKWELL PUBLISHING.

Brust, A., Alewood, D., Colless, B., Palant, E., Patterson, B., Wilson, D. T. R., Watson, F., Schroeder, C. I., Alewood, P. F. and Lewis, R. J. (2006). Conopeptide to drug: The development, structure and activity correlation of XEN2174. 29th European Peptide Symposium, Gdansk, Poland, 3-8 September, 2006,. Chichester, England: John Wiley & Sons Ltd. doi: 10.1002/psc.797

Tsai, Vicky W. W., Scott, Heather L ., Lewis, Richard J. and Dodd, Peter R. (2005). The role of group I metabotropic glutamate receptor's in neuronal excitotoxicity in Alzheimer's disease. 1st Annual Meeting of the Australian-Dementia-and-Neurodegenerative-Diseases-Research-Group, Melbourne, Australia, 31 January, 2004. Mountain Home: F P Graham Publishing Co. doi: 10.1007/BF03033782

Smith, M. T., Nielsen, C. K., Hwang, J. C., Kydd, S., Wyse, B. D., Lewis, R. J. and Drinkwater, R. D. (2005). Intrathecal XEN2174 produces significant anti-allodynia in morphine-tolerant rats using the CCI-model of persistent neuropathic pain. 11th World Congress on Pain, Sydney, Australia, 21-26 August 2005. Seattle, Wa.: IASP Press.

Nielsen, C., Smith, M. T., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. CPT2004: 8th World Congress on Clinical Pharmacology & Therapeutics, Brisbane, Qld, Australia, 1-6 August, 2004. Oxford, United Kingdom: Blackwell Scientific Publications. doi: 10.1111/j.1440-1681.2004.cep_4027.pdf.x

Chen, Z. J., Hague, C., Alewood, D., Lewis, R. J. and Minneman, K. (2004). Differential interactions of p-TIA with human alpha(1)-adrenergic receptor (AR) subtypes. Experimental Biology 2004 Meeting, Washington, D.C., 17th - 21st April, 2004. Bethesda, MD: Federation of American Societies for Experimental Biology.

Skinner, M. P., Lewis, R. J., Johnstone, Ron W. and Shaw, G. R. (2004). The Ecotoxicology of a benthic HAB (Prorocentrum) bloom, nutrients and ciguatera, Rarotonga, Cook Islands. XIth International Conference on Harmful Algae, Cape Town, South Africa, 14-19 November, 2004. Amsterdam ; New York: Elsevier Science.

Ragnarsson, L. K., Yasuda, T., Adams, D. J., Lewis, R. J. and Dodd, P. R. (2004). NMDA receptor variant responses to conantokins. 6th Biennial Meeting of Asian-Pacific Society for Neurochemistry, Hong Kong, 4th - 7th February, 2004. Oxford, UK: Blackwell. doi: 10.1046/j.1474-1644.2003.2314p26_01.x

Blanchfield, J. T., Gallagher, O. P., Koda, Y., Alewood, P.F., Lewis, R. J. and Toth, I. (2004). Liposaccharides in peptide drug delivery. 18th American Peptide Symposium, Boston, 19-23 July, 2003. WASHINGTON: AMER CHEMICAL SOC.

Smith, M. T., Nielsen, C., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract. ANZCA Annual Scientific Meeting, Perth, Western Australia, 1-5 May, 2004. Australia: ANZCA.

Schroeder, CI, Nielsen, KJ, Adams, DA, Loughnan, M, Thomas, L, Bourne, GT, Smythe, ML, Alewood, PF, Craik, DJ and Lewis, RJ (2004). From Omega-Conotoxins to Macrocycle Mimetics. CHICHESTER: JOHN WILEY & SONS LTD.

Ragnarsson, L, Yasuda, T, Adams, DJ, Lewis, RJ and Dodd, PR (2004). NMDA receptor variant responses to conantokins. 6th Biennial Meeting of the Asian-Pacific-Society-for-Neurochemistry, Hong Kong Peoples R China, Feb 04-07, 2004.

Oliver, L. M., Shaw, G. R., Moore, M. R., Lewis, R. J. and Seymour, J. (2003). The epidemiology of ciguatera in Australia. The threat and the true prevalance of ciguatera fish poisoning. Australian Seafood Industry Conference, Perth, 17-19 September 2003. Australia: Australian Seafood Industry.

Oliver, L. M., Shaw, G. R., Moore, M. R., Lewis, R. J. and Seymour, J (2003). The presence of ciguatera in Australian fish species.. Australian Seafood Industry Conference, Perth, 17-19 September 2003. Australia: Australian Seafood Industry.

Ragnarsson, L, Dodd, P and Lewis, R (2002). Regional variation in the, pharmacology of NMDA receptors in normal and Alzheimer disease human cortex: Interactions with polyamines and conantokins. NEW YORK: ELSEVIER SCIENCE INC.

Mould, J. A., Alewood, P. F., Lewis, R. J. and Adams, D. J. (2002). Affinity of omega-conotoxins and analogs for N-type calcium channels. Array, Bethesda, x.

Nielsen, C., Ross, F. B., Lewis, R. J., Drinkwater, R. D. and Smith, M. T. (2002). Anti-allodynic efficacy of the x-conipeptide, MR1A, in rats with neuropathic pain. AHMR Congress 2002, Melbourne, 24-29 Nov. 2002. Melbourne: NHMRC.

Nielsen, C., Ross, F. B., Lewis, R. J., Drinkwater, R. D. and Smith, M. T. (2002). Anti-allodynic efficacy of the conopeptide, MR1A, in rats with neuropathic pain. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.

Ragnarsson, L., Dodd, P. R. and Lewis, R. J. (2002). Regional variation in the pharmacology of NMDA receptors in normal and Alzheimer disease human cortex: Interactions with polyamines and conantokins. 8th Int Conf on Alzheimer's Disease and Related Disorders, Stockholm, 20-25 July, 2002.

Ragnarsson, L., Dodd, P. R. and Lewis, R. J. (2002). Characterization of the effects of polyamines and conantokins on NMDA receptors in normal and Alzheimer disease human cortex. ISN-APSN Joint Neurochemistry Workshop, Salaya, Thailand, 28-30 November, 2002.

Ragnarsson, L., Dodd, P. R. and Lewis, R. J. (2002). Conantokin probes of NMDA receptors in normal and Alzheimer disease human cerebral cortex. Australian Neuroscience Society 22nd Annual Meeting, Sydney, 4-6 February, 2002.

Nicke, A. C., Loughnan, M., Thomas, L., Alewood, P. F., Adams, D. J. and Lewis, R. J. (2002). Isolation of a novel conotoxin that targets alpha 7 and alpha 3 beta 2 neuronal nicotinic acetylcholine receptors. x, x, 2002. Bethesda, MD.: Cell Press for the Biophysical Society.

Smith, A. B., Schroeder, T. I. C., Lewis, R. J., Alewood, P. F. and Adams, D. J. (2001). Inhibition of neurotransmitter release by novel w-conotoxins in rat preganglionic terminals. Physiological Society Scientific Meeting, King's College, London, 18 - 20 December, 2000. London: The Physiological Society.

Tsai, W., Huygens, F., Dodd, P. R. and Lewis, R. (2001). Functional studies of recombinant NR1 proteins in mammalian cells. Australian Neuroscience Society 21st Annual Meeting, Brisbane, 28th - 31st January, 2001.

Blanchfield, J. T., Alewood, P.F., Lewis, R. J., Dutton, J. L., Craik, D. J. and Toth, I. (2001). Synthesis of lipo- and liposacchride a-conotoxin MII conjugates. World Chemistry Congress, Brisbane, Australia, 1-6 July, 2001. Royal Australian Chemical Institute.

Ragnarsson, L., Dodd, P. R. and Lewis, R. J. (2001). Conantokins inhibit spermine-enhanced [ 3-H]MK-801 binding in normal and Alzheimer disease human cortex. Australian Neuroscience Society 21st Annual Meeting, Brisbane, 28th - 31st January, 2001.

Blanchfield, J. T., Dutton, J. L., Craik, D. J., Alewood, P.F., Lewis, R. J., Adams, D. J. and Toth, I. (2001). Synthesis of lipo- and liposaccharide a-conotoxin MII conjugates.. APSA Annual Conference 2001, Melbourne, Australia, 9-12 December, 2001. Melbourne, Australia: Australasian Pharmaceutical Science Association.

Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Adams, D. J., Alewood, P. F., Blanchfield, J. T., Lewis, R. J. and Toth, I. (2000). A novel liposaccharide based system for peptide drug delivery. The First Brisbane Biological and Organic Chemistry Symposium, Griffith University, Brisbane, 27 November. 2000.

Blanchfield, J. T., Adams, D. J., Alewood, P. F., Lewis, R. J. and Toth, I. (2000). A novel liposaccharide based system for peptide drug delivery. The APSA 2000 Annual Conference, Newcastle, 6th - 8th December, 2000. Australia: APSA.

Smith, A. B., Schroeder, T. I. C., Lewis, R. J., Alewood, P. F. and Adams, D. J. (2000). Inhibition of neurotransmitter release by novel w-conotoxins in rat submandibular ganglia. 20th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, Melbourne, Australia, 30 January - 2 February, 2000. Australia: The Australian Neuroscience Society.

Lewis, R., Jones, A. and Vernoux, J. (1999). HPLC/Mass Spectrometry and HPLC/MS/MS/ methods for the detection of Multiple Ciguatoxins. 5th Indo-Pac Fish Conference, Noumea, New Caledonia, 3rd - 8th November, 1997. Paris, France: Societe Francaise Ichtyologie.

Ragnarsson, L., Eckert, A. L., Dodd, P. R. and Lewis, R. J. (1999). Spermine modulation of the glutamate NMDA site is differentially responsive to conantokins in normal and ALzheimer disease human cerebral cortex. 19th Annual Meeting of the Australian Neuroscience Society, Hobart Convention Centre, Hobart, 31st January - 3rd February, 1999. Melbourne: Australian Neuroscience Society.

Hogg, R. C., Lewis, R. and Adams, D. J. (1999). a-Conotoxin analogue, PnIA (AI0L), and a-Bungarotoxin block the same component of nicotinic ACh-Induced current in rat parasympathetic neurones. 19th Annual Meeting of the Australian Neuroscience Society, Univ. of Tas., Hobart, Aust., 31 Jan - 03 Feb, 1999. Aust.: Aust. Neuroscience Society.

Luchian, T., Lewis, R. and Adams, D. J. (1999). Modulatory effects of the b3 subunit on w-conotosin binding to neuronal N-Type calcium channels. 67th Meeting of the APPS, Newcastle, Aust., 27-29 September 1999. Aust.: Aust. Physiological and Pharmacological Society.

Dodd, P. R., Ragnarsson, L., Eckert, A. L., Alewood, P. F. and Lewis, R. (1999). Effect of conantokins on the spermine modulation of glutamate-NMDA sites in normal and Alzheimer disease human cerebral cortex. Joint meeting of the International Society for Neurochemistry (ISN) and the European Society for Chemistry (ESN), Berlin, Germany, 8 - 14 August, 1999. Hagerstown: Lipponcott-Raven.

Hamilton, B., Lewis, R., Chiswell, B., Moore, M. and Jones, A. (1999). Development of analytical detection methodologies of ciguatoxins. 6th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Cairns, 13th - 17th September, 1999. Ontario: International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

Jones, A, Bingham, JP, Gehrmann, J, Bond, T, Loughnan, M, Atkins, A, Lewis, RJ and Alewood, PF (1996). Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry. 15th Conference of the Australian-and-New-Zealand-Society-for-Mass-Spectrometry (ANZSMS-15) - Mass Spectrometry in the 90s, Sydney Australia, Sep 24-29, 1995. W SUSSEX: JOHN WILEY & SONS LTD. doi: 10.1002/(SICI)1097-0231(19960115)10:1<138::AID-RCM442>3.0.CO;2-3

Professor Richard Lewis

Researcher biography

Publications

Book Chapters

Journal Articles

Conference Papers