Researcher biography

Endosomal Dynamics and Neurodegeneration

The endosomal system of mammalian cells is a highly dynamic organelle, and the trafficking pathways associated with it are fundamental for a wide variety of cellular processes. We are developing cellular and computational approaches to identify novel mammalian proteins associated with the endosomal system including the retromer protein complex that is a central regulator of early endosome protein trafficking. Retromer has been recently implicated in both Alzheimer's and Parkinson's neurological diseases and we are investigating the molecular mechanisms underlying these diseases.