School of Biomedical Sciences

Dr Sherry Wu

Senior Lecturer
School of Biomedical Sciences
+61 7 336 52785
View researcher profile

Dr Sherry Wu heads the cancer therapeutics lab.

Research Biography

Dr Sherry Wu obtained her undergraduate training in Pharmacy at the University of Queensland. She subsequently received her Ph.D. degree in the field of cancer medicine at the University of Queensland in 2010. She then undertook postdoctoral translational cancer research fellowships at Johns Hopkins University and the University of Texas M.D. Anderson Cancer Center. In late 2017, Dr. Wu took up an academic position at UQ School of Biomedical Sciences to continue with her research in cancer therapeutics.

Dr Wu has expertise in target discovery using large-scale experimental databases, in vitro and in vivo validation models, nanotechnology, and molecular biology techniques for studying mechanisms of action and resistance. Her research focuses on:

  1. Developing strategies to overcome immune suppression in ovarian and breast cancers
  2. Developing novel nanoparticle platforms for tumor-targeted delivery
  3. Developing novel strategies to enhance patient survival in ovarian and breast cancers.
Qualifications
  • Graduate Certificate in Translational Cancer Research, the University of Texas M.D. Anderson Cancer Center (TRIUMPH program)
  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Pharmacy, The University of Queensland
PhD and Mphil Supervision

For all enquiries regarding research supervision, please contact ask@uq.edu.au. For all enquiries regarding potential research projects, please contact Dr Wu (sherry.wu@uq.edu.au).

Opportunities for New Researchers

Positions are available across our research program for undergraduates, honours students, PhD students, and postdoctoral fellows. If you are interested in joining our lab, please contact Dr Wu (sherry.wu@uq.edu.au).

Potential research projects include, but not limited to:

  • Theme 1: Understand factors contributing to immune suppression in cancer
  • Theme 2: Develop clinically translatable nanosystems to break down immune barriers
Selected Publications
Original Research Articles

Court KA, Hatakeyama H, Wu SY, Lingegowda MS, Rodríguez-Aguayo C, López-Berestein G, et al. HSP70 Inhibition Synergistically Enhances the Effects of Magnetic Fluid Hyperthermia in Ovarian Cancer. Molecular Cancer Therapeutics 2017, 16(5):966-976.

Wu, S.Y., Rupaimoole, R., Shen, F., Pradeep, S., Pecot, C.V., Ivan, C., et al. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nature Communications 2016, 7:111169.

Hatakeyama, H., Wu, S.Y., Lyons, Y.A., Pradeep, S., Wang, W., Huang, Q., et al. Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers. Cell Reports 2016, 17(6):1621-31.

Miyake TM, Pradeep S, Wu SY, Rupaimoole R, Zand B, Wen Y, et al. XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. Clinical Cancer Research 2015, 21(14):3286-97.

Wu, S.Y., Yang, X.B., Gharpure, K., Hatakeyama, H., Egli, M., McGuire, M., et al. 2’-OMe-phosphorodithioate modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nature Communications 2014, 5, 3459.

Rupaimoole, R.; Wu, S.Y.; Pradeep, S.; Ivan, C.; Pecot, C.V.; Gharpure, K.M.; et al. Hypoxia mediated downregulation of miRNA biogenesis leads to increased tumor progression. Nature Communications 2014, 5:5202.

Pradeep, S., Kim, S.W., Wu, S.Y., Nishimura, M., Chaluvally-Raghavan, P., Miyake, T., et al. Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell 2014, 26(1):77-91.

Pecot, C.V., Wu, S.Y., Bellister, S., Bhattacharya, R., Maharaj, A., Rodriguez-Aguayo, C., et al. Therapeutic Silencing of KRAS using Systemically Delivered siRNAs. Molecular Cancer Therapeutics 2014, 13(12):2876-85.

Cho, M.S., Vasquez, H.G., Rupaimoole, R., Pradeep, S., Wu, S., Zand, B., et al. Cell Reports 2014, pii: S2211-1247(14)00114-4.

McCaskill, J.; Singhania, R., Burgess, M., Allavena, R., Wu, S.Y., Blumenthal, A., et al. Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA. Molecular Therapy – Nucleic Acids 2013, 2:e96.

Wu, S.Y.; Chang, H.I.; Burgess, M.; McMillan N.A.J. Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system. Journal of Controlled Release 2011, 155(3):418-26.

Wu, S.Y., Singhania, A., Burgess, M., Putral, L., Kirkpatrick, C., Davies, N.M., et al. Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models.  Gene Therapy 2011, 18(1): 14-22.

Singhania, A.*, Wu, S.Y.*, McMillan, N.A.J. Effective delivery of PEGylated siRNA-containing lipoplexes to extraperitoneal tumours following intraperitoneal administration. Journal of Drug Delivery 2011, e192562.

*These authors contributed equally to the work.

Khairuddin, N., Gantier, M.P., Blake, S., Wu, S.Y., Behlke, M.A., Williams, B.R.G., et al. SiRNA-induced immunostimulation through TLR7 promotes anti-tumoral activity against HPV-driven tumors in vivo. Immunology & Cell Biology 2011, 90(2):187-96.

Wu, S.Y.; Putral, L.N.; Liang M.; Chang H.I.; Davies N.M.; McMillan N.A.J. Development of a novel method for formulating stable siRNA-loaded lipid particles for in vivo use. Pharmaceutical Research 2009, 26(3):512-22.

Wu, S.; Campbell, C.; Koda, Y.; Blanchfield, J.T.; Toth, I. Investigation of the route of absorption of lipid and sugar modified Leu-enkephalin analogues and their enzymatic stability using the Caco-2 cell monolayer system. Medicinal Chemistry 2006, 2(2):203-11.

Review Articles

Lyons, Y., Wu, S.Y., Overwijk, W.W., Baggerly, K.A., Sood, A.K. Immune cell profiling in cancer: molecular approaches to cell-specific identification. NPJ Precision Oncology. (In Press)

Sercombe L., Veerati, T., Mohemani, F., Wu, S.Y., Sood, A.K., Hua, S. Advances and challenges of liposome assisted drug delivery. Frontiers in Pharmacology 2015, 6:286.

Gharpure, K., Wu, S.Y., Li, C., Lopez-Berestein, G., and Sood, A.K. Nanotechnology: Future of oncotherapy. Clinical Cancer Research 2015, 21(14):3121-30.

Wu, S.Y.; Lopez-Berestein, G.; Calin, G.A.; Sood, A.K. RNAi therapeutics: Drugging the undruggable. Science Translational Medicine 2014, 6:240ps7.

Hua, S.; Wu, S.Y. The use of lipid-based nanocarriers for targeted pain therapies. Frontiers in Neuropharmacology 2013, 4: 143.

Wu, S.Y. and McMillan N.A.J. Lipidic systems for in vivo siRNA delivery. American Association of Pharmaceutical Scientists Journal 2009, 11(4):639-52.

Editorials/Commentary/Book Chapters

Hatakeyama, H., Wu, S.Y., Mangala, L.S., Lopez-Berestein, G., Sood, A.K. Assessment of In Vivo siRNA Delivery in Cancer Mouse Models. Methods Mol Biol 2016,1402:189-97.

McCaskill, J.L., Wu, S., Khairuddin, N., and McMillan, N.A. Lowering the siRNA delivery barrier: Alginate Scaffolds and Immune stimulation. In: Peer D, editor. Nanotechnology for delivery of Therapeutic Nucleic Acids. Pan Stanford Publishing Pte. Ltd. pp. 193-216 (2013).

Wu, S.Y. and Sood A.K. New Roles Opined for OPCML. Cancer Discovery 2012, 2(2): 115–6.

Wu, S.Y. Cancer therapy hits its target. Australasian Science, 2010 April, p28-30.

Grants

2018-2020    Cancer Institute NSW Career Development Fellowship - Targeting the “undruggable”: Re-activating anti-tumour   immunity by silencing N-MYC in ovarian cancer and neuroblastoma (Declined, due to relocation to Brisbane)

2017-2018    National Institute of Health (NIH) R35 Maximizing Investigators’ Research Award - In vivo genetic engineering of T-cells for treatment of human diseases.

2017-2018    Australian Ovarian Cancer Research Foundation - Re-activating anti-tumour immunity by targeting N-MYC-Let7 axis in ovarian cancer.

2017-2024    National Institute of Health (NIH) R35 - Harnessing the power of exosomes for non-coding RNA delivery.

2016-2019    Ovarian Cancer Research Fund Alliance The Liz Tilberis Early Career Award - Re-activating anti-tumor immunity using non-coding RNAs.

2016-2017    Colleen’s Dream Foundation Pilot Study Grant - Using exosomes for detection of ovarian cancer.

2015             Texas Center for Cancer Nanomedicine Pilot study grant - Development of biomimetic nanosystems for delivering miRNAs for cancer treatment.

2014-2017    Foundation for Women’s Cancer - Caring Together, NY Ovarian Cancer Research Grant

2013-2015    Cancer Prevention Research Institute of Texas Keck Computational Cancer Biology Postdoctoral Fellowship

2013-2014    Texas Center for Cancer Nanomedicine Postdoc Research Award - A biomimetic bi-functional controlled release delivery platform for cancer treatment

2011-2014    Cancer Prevention Research Institute of Texas TRIUMPH (Translational Research in Multi-Disciplinary Program) Postdoctoral Fellowship

2011-2013    Ovarian Cancer Research Fund Ann Schreiber Mentored Investigator Grant - Novel anti-angiogenic strategies for ovarian cancer treatment.

2006-2009    NHMRC Postgraduate Scholarship - Delivery of siRNA for cancer treatment.

 

Publications

Book Chapters (2)
Journal Articles (56)
Conference Papers (3)

Book Chapters

Hatakeyama, Hiroto, Wu, Sherry Y., Mangala, Lingegowda S., Lopez-Berestein, Gabriel and Sood, Anil K. (2016). Assessment of in Vivo siRNA delivery in cancer mouse models. Long non-coding RNAs: methods and protocols. (pp. 189-197) edited by Yi Feng and Lin Zhang. Totowa, NJ USA: Humana Press. doi: 10.1007/978-1-4939-3378-5_15
McCaskill, Jana, Wu, Sherry, Khairuddin, Norliana and McMillan, Nigel A. J. (2013). Lowering the sirna delivery barrier: Alginate scaffolds and immune stimulation. Nanotechnology for the delivery of therapeutic nucleic acids. (pp. 193-216) edited by Dan Peer. Singapore: Pan Stanford Publishing. doi: 10.4032/9789814411059

Journal Articles

Wilkinson, Andrew N., Chen, Rui, Coleborn, Elaina, Neilson, Trent, Le, Khang, Bhavsar, Chintan, Wang, Yue, Atluri, Sharat, Irgam, Gowri, Wong, Kiefer, Yang, Da, Steptoe, Raymond and Wu, Sherry Y. (2024). Let-7i enhances anti-tumour immunity and suppresses ovarian tumour growth. Cancer Immunology, Immunotherapy, 73 (5) 80. doi: 10.1007/s00262-024-03674-w
Chen, Rui, Coleborn, Elaina, Bhavsar, Chintan, Wang, Yue, Alim, Louisa, Wilkinson, Andrew N., Tran, Michelle A., Irgam, Gowri, Atluri, Sharat, Wong, Kiefer, Shim, Jae-Jun, Adityan, Siddharth, Lee, Ju-Seog, Overwijk, Willem W., Steptoe, Raymond, Yang, Da and Wu, Sherry Y. (2023). miR-146a inhibits ovarian tumour growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration. Molecular Therapy - Oncolytics, 31 100725, 1-15. doi: 10.1016/j.omto.2023.09.001
Stur, Elaine, Bayraktar, Emine, Dal Molin, Graziela Zibetti, Wu, Sherry Y., Mangala, Lingegowda S., Yao, Hui, Wang, Ying, Ram, Prahlad T., Corvigno, Sara, Chen, Hu, Liang, Han, Tworoger, Shelley S., Levine, Douglas A., Lutgendorf, Susan K., Liu, Jinsong, Moore, Kathleen N., Baggerly, Keith A., Karlan, Beth Y. and Sood, Anil K. (2022). Molecular analysis of short- versus long-term survivors of high-grade serous ovarian carcinoma. Cancers, 14 (17) 4198. doi: 10.3390/cancers14174198
McGuire, Michael H., Dasari, Santosh K., Yao, Hui, Wen, Yunfei, Mangala, Lingegowda S., Bayraktar, Emine, Ma, Wencai, Ivan, Cristina, Shoshan, Einav, Wu, Sherry Y., Jonasch, Eric, Bar-Eli, Menashe, Wang, Jing, Baggerly, Keith A. and Sood, Anil K. (2021). Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling. Molecular Cancer Research, 19 (11), 1917-1928. doi: 10.1158/1541-7786.MCR-20-0753
Ma, Shaolin, Mangala, Lingegowda S., Hu, Wen, Bayaktar, Emine, Yokoi, Akira, Hu, Wei, Pradeep, Sunila, Lee, Sanghoon, Piehowski, Paul D., Villar-Prados, Alejandro, Wu, Sherry Y., McGuire, Michael H., Lara, Olivia D., Rodriguez-Aguayo, Cristian, LaFargue, Christopher J., Jennings, Nicholas B., Rodland, Karin D., Liu, Tao, Kundra, Vikas, Ram, Prahlad T., Ramakrishnan, Sundaram, Lopez-Berestein, Gabriel, Coleman, Robert L. and Sood, Anil K. (2021). CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance. Cell Reports, 36 (7). doi: 10.1016/j.celrep.2021.109549
Ma, Shaolin, McGuire, Michael H., Mangala, Lingegowda S., Lee, Sanghoon, Stur, Elaine, Hu, Wen, Bayraktar, Emine, Villar-Prados, Alejandro, Ivan, Cristina, Wu, Sherry Y., Yokoi, Akira, Dasari, Santosh K., Jennings, Nicholas B., Liu, Jinsong, Lopez-Berestein, Gabriel, Ram, Prahlad and Sood, Anil K. (2021). Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. Cell Reports, 34 (6). doi: 10.1016/j.celrep.2021.108726
Mori, Noriko, Mironchik, Yelena, Wildes, Flonné, Wu, Sherry Y., Mori, Kanami, Krishnamachary, Balaji and Bhujwalla, Zaver M. (2020). HIF and COX-2 expression in triple negative breast cancer cells with hypoxia and 5-fluorouracil. Current Cancer Reports, 2 (1), 54-63. doi: 10.25082/CCR.2020.01.005
Adityan, Siddharth, Tran, Michelle, Bhavsar, Chintan and Wu, Sherry Y. (2020). Nano-therapeutics for modulating the tumour microenvironment: design, development, and clinical translation. Journal of Controlled Release, 327 (Acta Biomater. 62 2017), 512-532. doi: 10.1016/j.jconrel.2020.08.016
Noh, Kyunghee, Duc-Hiep Bach, , Choi, Hyun-Jin, Kim, Mark S., Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Cho, Min-Soon, Bayraktar, Emine, Rodriguez-Aguayo, Cristian, Dasari, Santosh K., Stur, Elaine, Mangala, Lingegowda S., Lopez-Berestein, Gabriel and Sood, Anil K. (2020). The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis. Oncogene, 40 (2), 384-395. doi: 10.1038/s41388-020-01517-3
Liu, Yuan, Wu, Sherry, Koo, Yeonjong, Yang, An, Dai, Yanwan, Khant, Htet, Osman, Samantha R., Chowdhury, Mamur, Wei, Haichao, Li, Yang, Court, Karem, Hwang, Elaine, Wen, Yunfei, Dasari, Santosh K., Nguyen, Michael, Tang, E. Chia-Cheng, Chehab, E. Wassim, de Val, Natalia, Braam, Janet and Sood, Anil K. (2020). Characterization of and isolation methods for plant leaf nanovesicles and small extracellular vesicles. Nanomedicine-Nanotechnology Biology and Medicine, 29 102271. doi: 10.1016/j.nano.2020.102271
Miyake, Takahito M., Pradeep, Sunila, Bayraktar, Emine, Stur, Elaine, Handley, Katelyn F., Wu, Sherry Y., Rodriguez-Aguayo, Cristian, Lee, Ju-Seog, Lopez-Berestein, Gabriel, Coleman, Robert L. and Sood, Anil K. (2020). NRG1/ERBB3 pathway activation induces acquired resistance to XPO1 inhibitors. Molecular Cancer Therapeutics, 19 (8), 1727-1735. doi: 10.1158/1535-7163.MCT-19-0977
Shi, Sixiang, Li, Tingting, Wen, Xiaofei, Wu, Sherry Y., Xiong, Chiyi, Zhao, Jun, Lincha, Victor R., Chow, Diana S., Liu, Yiyao, Sood, Anil K. and Li, Chun (2019). Copper-64 labeled PEGylated exosomes for in vivo positron emission tomography and enhanced tumor retention. Bioconjugate Chemistry, 30 (10), 2675-2683. doi: 10.1021/acs.bioconjchem.9b00587
Endo-Munoz, Liliana, Bennett, Tristram C., Topkas, Eleni, Wu, Sherry Y., Thamm, Douglas H., Brockley, Laura, Cooper, Maureen, Sommerville, Scott, Thomson, Maurine, O'Connell, Kathleen, Lane, Amy, Bird, Guy, Peaston, Anne, Matigian, Nicholas, Straw, Rodney C. and Saunders, Nicholas A. (2019). Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma. Veterinary and Comparative Oncology, 18 (2) vco.12533, 206-213. doi: 10.1111/vco.12533
McGuire, Michael H., Herbrich, Shelley M., Dasari, Santosh K., Wu, Sherry Y., Wang, Ying, Rupaimoole, Rajesha, Lopez-Berestein, Gabriel, Baggerly, Keith A. and Sood, Anil K. (2019). Pan-cancer genomic analysis links 3'UTR DNA methylation with increased gene expression in T cells. Ebiomedicine, 43, 127-137. doi: 10.1016/j.ebiom.2019.04.045
Villar-Prados, Alejandro, Wu, Sherry Y., Court, Karem A., Ma, Shaolin, LaFargue, Christopher, Chowdhury, Mamur A., Engelhardt, Margaret I., Ivan, Cristina, Ram, Prahlad T., Wang, Ying, Baggerly, Keith, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Ming-Yang, Shyh, Maloney, David J., Yoshioka, Makoto, Strovel, Jeffrey W., Roszik, Jason and Sood, Anil K. (2019). Predicting novel therapies and targets: regulation of notch3 by the Bromodomain protein BRD4. Molecular Cancer Therapeutics, 18 (2), 421-436. doi: 10.1158/1535-7163.MCT-18-0365
Hua, Susan and Wu, Sherry Y. (2018). Advances and challenges in nanomedicine. Frontiers in Pharmacology, 9 (Nov) 1397, 1397. doi: 10.3389/fphar.2018.01397
Yang, Mengliu and Wu, Sherry Y. (2018). The advances and challenges in utilizing exosomes for delivering cancer therapeutics. Frontiers in Pharmacology, 9 (JUL) 735, 735. doi: 10.3389/fphar.2018.00735
Lyons, Yasmin A., Wu, Sherry Y., Overwijk, Willem W., Baggerly, Keith A. and Sood, Anil K. (2017). Immune cell profiling in cancer: molecular approaches to cell-specific identification. Npj Precision Oncology, 1 (26) 26. doi: 10.1038/s41698-017-0031-0
Sarkar, Sharmistha, Bristow, Christopher A., Dey, Prasenjit, Rai, Kunal, Perets, Ruth, Ramirez-Cardenas, Alejandra, Malasi, Shruti, Huang-Hobbs, Emmet, Haemmerle, Monika, Wu, Sherry Y., McGuire, Michael, Protopopov, Alexei, Jiang, Shan, Liu, Joyce F., Hirsch, Michelle S., Chang, Qing, Lazar, Alexander J., Sood, Anil K., Drapkin, Ronny, DePinho, Ronald, Draetta, Giulio and Chin, Lynda (2017). PRKCI promotes immune suppression in ovarian cancer. Genes and Development, 31 (11), 1109-1121. doi: 10.1101/gad.296640.117
Wagner, Michael J., Mitra, Rahul, McArthur, Mark J., Baze, Wallace, Barnhart, Kirstin, Wu, Sherry Y., Rodriguez-Aguayo, Cristian, Zhang, Xinna, Coleman, Robert L., Lopez-Berestein, Gabriel and Sood, Anil K. (2017). Preclinical mammalian safety studies of EPHARNA (DOPC Nanoliposomal EphA2-Targeted siRNA). Molecular Cancer Therapeutics, 16 (6), 1114-1123. doi: 10.1158/1535-7163.MCT-16-0541
Court, Karem A., Hatakeyama, Hiroto, Wu, Sherry Y., Lingegowda, Mangala S., Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Ju-Seog, Lee, Rinaldi, Carlos, Juan, Eduardo J., Sood, Anil K. and Torres-Lugo, Madeline (2017). HSP70 inhibition synergistically enhances the effects of magnetic fluid hyperthermia in ovarian cancer. Molecular Cancer Therapeutics, 16 (5), 966-976. doi: 10.1158/1535-7163.MCT-16-0519
Hatakeyama, Hiroto, Wu, Sherry Y., Lyons, Yasmin A., Pradeep, Sunila, Wang, Wanqin, Huang, Qian, Court, Karem A., Liu, Tao, Nie, Song, Rodriguez-Aguayo, Cristian, Shen, Fangrong, Huang, Yan, Hisamatsu, Takeshi, Mitamura, Takashi, Jennings, Nicholas, Shim, Jeajun, Dorniak, Piotr L., Mangala, Lingegowda S., Petrillo, Marco, Petyuk, Vladislav A., Schepmoes, Athena A., Shukla, Anil K., Torres-Lugo, Madeline, Lee, Ju-Seog, Rodland, Karin D., Fagotti, Anna, Lopez-Berestein, Gabriel, Li, Chun and Sood, Anil K. (2016). Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers. Cell Reports, 17 (6), 1621-1631. doi: 10.1016/j.celrep.2016.10.020
Yokoyama, Yuhki, Zhu, Hengrui, Lee, Jeong Heon, Kossenkov, Andrew V., Wu, Sherry Y., Wickramasinghe, Jayamanna M., Yin, Xiangfan, Palozola, Katherine C., Gardini, Alessandro, Showe, Louise C., Zaret, Kenneth S., Liu, Qin, Speicher, David, Conejo-Garcia, Jose R., Bradner, James E., Zhang, Zhiguo, Sood, Anil K., Ordog, Tamas, Bitler, Benjamin G. and Zhang, Rugang (2016). BET inhibitors suppress ALDH activity by targeting ALDH1A1 super-enhancer in ovarian cancer. Cancer Research, 76 (21), 6320-6330. doi: 10.1158/0008-5472.CAN-16-0854
Rupaimoole, R., Ivan, C., Yang, D., Gharpure, K. M., Wu, S. Y., Pecot, C. V., Previs, R. A., Nagaraja, A. S., Armaiz-Pena, G. N., McGuire, M., Pradeep, S., Mangala, L. S., Rodriguez-Aguayo, C., Huang, L., Bar-Eli, M., Zhang, W., Lopez-Berestein, G., Calin, G. A. and Sood, A. K. (2016). Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. Oncogene, 35 (33), 4312-4320. doi: 10.1038/onc.2015.492
Zand, Behrouz, Previs, Rebecca A., Zacharias, Niki M., Rupaimoole, Rajesha, Mitamura, Takashi, Nagaraja, Archana Sidalaghatta, Guindani, Michele, Dalton, Heather J., Yang, Lifeng, Baddour, Joelle, Achreja, Abhinav, Hu, Wei, Pecot, Chad V., Ivan, Cristina, Wu, Sherry Y., McCullough, Christopher R., Gharpure, Kshipra M., Shoshan, Einav, Pradeep, Sunila, Mangala, Lingegowda S., Rodriguez-Aguayo, Cristian, Wang, Ying, Nick, Alpa M., Davies, Michael A., Armaiz-Pena, Guillermo, Liu, Jinsong, Lutgendorf, Susan K., Baggerly, Keith A., Bar Eli, Menashe ... Sood, Anil K. (2016). Role of increased n-acetylaspartate Levels in cancer. JNCI-Journal of the National Cancer Institute, 108 (6), djv426. doi: 10.1093/jnci/djv426
Haemmerle, Monika, Bottsford-Miller, Justin, Pradeep, Sunila, Taylor, Morgan L., Choi, Hyun-Jin, Hansen, Jean M., Dalton, Heather J., Stone, Rebecca L., Cho, Min Soon, Nick, Alpa M., Nagaraja, Archana S., Gutschner, Tony, Gharpure, Kshipra M., Mangala, Lingegowda S., Rupaimoole, Rajesha, Han, Hee Dong, Zand, Behrouz, Armaiz-Pena, Guillermo N., Wu, Sherry Y., Pecot, Chad V., Burns, Alan R., Lopez-Berestein, Gabriel, Afshar-Kharghan, Vahid and Sood, Anil K. (2016). FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal. Journal of Clinical Investigation, 126 (5), 1885-1896. doi: 10.1172/JCI85086
Wu, Sherry Y., Rupaimoole, Rajesha, Shen, Fangrong, Pradeep, Sunila, Pecot, Chad V., Ivan, Cristina, Nagaraja, Archana S., Gharpure, Kshipra M., Pham, Elizabeth, Hatakeyama, Hiroto, McGuire, Michael H., Haemmerle, Monika, Vidal-Anaya, Viviana, Olsen, Courtney, Rodriguez-Aguayo, Cristian, Filant, Justyna, Ehsanipour, Ehsan A., Herbrich, Shelley M., Maiti, Sourindra N., Huang, Li, Kim, Ji Hoon, Zhang, Xinna, Han, Hee-Dong, Armaiz-Pena, Guillermo N., Seviour, Elena G., Tucker, Sue, Zhang, Min, Yang, Da, Cooper, Laurence J. N. ... Sood, Anil K. (2016). A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nature Communications, 7 (1) 11169. doi: 10.1038/ncomms11169
Rupaimoole, Rajesha, Lee, Jaehyuk, Haemmerle, Monika, Ling, Hui, Previs, Rebecca A., Pradeep, Sunila, Wu, Sherry Y., Ivan, Cristina, Ferracin, Manuela, Dennison, Jennifer B., Millward, Niki M. Zacharias, Nagaraja, Archana S., Gharpure, Kshipra M., McGuire, Michael, Sam, Nidhin, Armaiz-Pena, Guillermo N., Sadaoui, Nouara C., Rodriguez-Aguayo, Cristian, Calin, George A., Drapkin, Ronny I., Kovacs, Jeffery, Mills, Gordon B., Zhang, Wei, Lopez-Berestein, Gabriel, Bhattacharya, Pratip K. and Sood, Anil K. (2015). Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis. Cell Reports, 13 (11), 2395-2402. doi: 10.1016/j.celrep.2015.11.047
Sercombe, Lisa, Veerati, Tejaswi, Moheimani, Fatemeh, Wu, Sherry Y., Sood, Anil K. and Hua, Susan (2015). Advances and challenges of liposome assisted drug delivery. Frontiers in Pharmacology, 6. doi: 10.3389/fphar.2015.00286
Pradeep, Sunila, Huang, Jie, Mora, Edna M., Nick, Alpa M., Cho, Min Soon, Wu, Sherry Y., Noh, Kyunghee, Pecot, Chad V., Rupaimoole, Rajesha, Stein, Martin A., Brock, Stephan, Wen, Yunfei, Xiong, Chiyi, Gharpure, Kshipra, Hansen, Jean M., Nagaraja, Archana S., Previs, Rebecca A., Vivas-Mejia, Pablo, Han, Hee Dong, Hu, Wei, Mangala, Lingegowda S., Zand, Behrouz, Stagg, Loren J., Ladbury, John E., Ozpolat, Bulent, Alpay, S. Neslihan, Nishimura, Masato, Stone, Rebecca L., Matsuo, Koji ... Sood, Anil K. (2015). Erythropoietin stimulates tumor growth via EphB4. Cancer Cell, 28 (5), 610-622. doi: 10.1016/j.ccell.2015.09.008
Gaur, Sanchaika, Wen, Yunfei, Song, Jian H., Parikh, Nila U., Mangala, Lingegowda S., Blessing, Alicia M., Ivan, Cristina, Wu, Sherry Y., Varkaris, Andreas, Shi, Yan, Lopez-Berestein, Gabriel, Frigo, Daniel E., Sood, Anil K. and Gallick, Gary E. (2015). Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy. Oncotarget, 6 (30), 29161-29177. doi: 10.18632/oncotarget.4971
Gharpure, Kshipra M., Wu, Sherry Y., Li, Chun, Lopez-Berestein, Gabriel and Sood, Anil K. (2015). Nanotechnology: future of oncotherapy. Clinical Cancer Research, 21 (14), 3121-3130. doi: 10.1158/1078-0432.CCR-14-1189
Miyake, Takahito, Pradeep, Sunila, Wu, Sherry Y., Rupaimoole, Rajesha, Zand, Behrouz, Wen, Yunfei, Gharpure, Kshipra M., Nagaraja, Archana S., Hu, Wei, Cho, Min Soon, Dalton, Heather J., Previs, Rebecca A., Taylor, Morgan L., Hisamatsu, Takeshi, Kang, Yu, Liu, Tao, Shacham, Sharon, McCauley, Dilara, Hawke, David H., Wiktorowicz, John E., Coleman, Robert L. and Sood, Anil K. (2015). XPO1/CRM1 inhibition causes antitumor effects by mitochondrial accumulation of eIF5A. Clinical Cancer Research, 21 (14), 3286-3297. doi: 10.1158/1078-0432.CCR-14-1953
Pecot, Chad V., Wu, Sherry Y., Bellister, Seth, Filant, Justyna, Rupaimoole, Rajesha, Hisamatsu, Takeshi, Bhattacharya, Rajat, Maharaj, Anshumaan, Azam, Salma, Rodriguez-Aguayo, Cristian, Nagaraja, Archana S., Morelli, Maria Pia, Gharpure, Kshipra M., Waugh, Trent A., Gonzalez-Villasana, Vianey, Zand, Behrouz, Dalton, Heather J., Kopetz, Scott, Lopez-Berestein, Gabriel, Ellis, Lee M. and Sood, Anil K. (2014). Therapeutic silencing of KRAS using systemically delivered siRNAs. Molecular Cancer Therapeutics, 13 (12), 2876-2885. doi: 10.1158/1535-7163.MCT-14-0074
Rupaimoole, Rajesha, Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Pecot, Chad V., Gharpure, Kshipra M., Nagaraja, Archana S., Armaiz-Pena, Guillermo N., McGuire, Michael, Zand, Behrouz, Dalton, Heather J., Filant, Justyna, Miller, Justin Bottsford, Lu, Chunhua, Sadaoui, Nouara C., Mangala, Lingegowda S., Taylor, Morgan, van den Beucken, Twan, Koch, Elizabeth, Rodriguez-Aguayo, Cristian, Huang, Li, Bar-Eli, Menashe, Wouters, Bradly G., Radovich, Milan, Ivan, Mircea, Calin, George A., Zhang, Wei, Lopez-Berestein, Gabriel and Sood, Anil K. (2014). Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nature Communications, 5 (5202) 5202. doi: 10.1038/ncomms6202
Pradeep, Sunila, Kim, Seung W., Wu, Sherry Y., Nishimura, Masato, Chaluvally-Raghavan, Pradeep, Miyake, Takahito, Pecot, Chad V., Kim, Sun-Jin, Choi, Hyun Jin, Bischoff, Farideh Z., Mayer, Julie Ann, Huang, Li, Nick, Alpa M., Hall, Carolyn S., Rodriguez-Aguayo, Cristian, Zand, Behrouz, Dalton, Heather J., Arumugam, Thiruvengadam, Lee, Ho Jeong, Han, Hee Dong, Cho, Min Soon, Rupaimoole, Rajesha, Mangala, Lingegowda S., Sehgal, Vasudha, Oh, Sang Cheul, Liu, Jinsong, Lee, Ju-Seog, Coleman, Robert L., Ram, Prahlad ... Sood, Anil K. (2014). Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell, 26 (1), 77-91. doi: 10.1016/j.ccr.2014.05.002
Gharpure, Kshipra M., Chu, Kevin S., Bowerman, Charles J., Miyake, Takahito, Pradeep, Sunila, Mangala, Selanere L., Han, Hee-Dong, Rupaimoole, Rajesha, Armaiz-Pena, Guillermo N., Rahhal, Tojan B., Wu, Sherry Y., Luft, J. Christopher, Napier, Mary E., Lopez-Berestein, Gabriel, DeSimone, Joseph M. and Sood, Anil K. (2014). Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer. Molecular Cancer Therapeutics, 13 (7), 1750-1757. doi: 10.1158/1535-7163.MCT-13-0930
Hu, Wei, Liu, Tao, Ivan, Cristina, Sun, Yunjie, Huang, Jie, Mangala, Lingegowda S., Miyake, Takahito, Dalton, Heather J., Pradeep, Sunila, Rupaimoole, Rajesh, Previs, Rebecca A., Han, Hee Dong, Bottsford-Miller, Justin, Zand, Behrouz, Kang, Yu, Pecot, Chad V., Nick, Alpa M., Wu, Sherry Y., Lee, Ju-Seog, Sehgal, Vasudha, Ram, Prahlad, Liu, Jinsong, Tucker, Susan L., Lopez-Berestein, Gabriel, Baggerly, Keith A., Coleman, Robert L. and Sood, Anil K. (2014). Notch3 pathway alterations in ovarian cancer. Cancer Research, 74 (12), 3282-3293. doi: 10.1158/0008-5472.CAN-13-2066
Tucker, Susan L., Gharpure, Kshipra, Herbrich, Shelley M., Unruh, Anna K., Nick, Alpa M., Crane, Erin K., Coleman, Robert L., Guenthoer, Jamie, Dalton, Heather J., Wu, Sherry Y., Rupaimoole, Rajesha, Lopez-Berestein, Gabriel, Ozpolat, Bulent, Ivan, Cristina, Hu, Wei, Baggerly, Keith A. and Sood, Anil K. (2014). Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer. Clinical Cancer Research, 20 (12), 3280-3288. doi: 10.1158/1078-0432.CCR-14-0445
Wu, S. Y., Lopez-Berestein, G., Calin, G. A. and Sood, A. K. (2014). RNAi therapies: drugging the undruggable. Science Translational Medicine, 6 (240), 240ps7-240ps7. doi: 10.1126/scitranslmed.3008362
Wu, Sherry Y., Yang, Xianbin, Gharpure, Kshipra M., Hatakeyama, Hiroto, Egli, Martin, McGuire, Michael H., Nagaraja, Archana S., Miyake, Takahito M., Rupaimoole, Rajesha, Pecot, Chad V., Taylor, Morgan, Pradeep, Sunila, Sierant, Malgorzata, Rodriguez-Aguayo, Cristian, Choi, Hyun J., Previs, Rebecca A., Armaiz-Pena, Guillermo N., Huang Li, Martinez, Carlos, Hassell Tom, Ivan, Cristina, Sehgal, Vasudha, Singhania, Richa, Han, Hee-Dong, Su, Chang, Kim, Ji Hoon, Dalton, Heather J., Kovvali, Chandra, Keyomarsi, Khandan ... Sood, Anil K. (2014). 2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nature Communications, 5 (1) 3459. doi: 10.1038/ncomms4459
Cho, Min Soon, Vasquez, Hernan G., Rupaimoole, Rajesha, Pradeep, Sunila, Wu, Sherry, Zand, Behrouz, Han, Hee-Dong, Rodriguez-Aguayo, Cristian, Bottsford-Miller, Justin, Huang, Jie, Miyake, Takahito, Choi, Hyun-Jin, Dalton, Heather J., Ivan, Cristina, Baggerly, Keith, Lopez-Berestein, Gabriel, Sood, Anil K. and Afshar-Kharghan, Vahid (2014). Autocrine effects of tumor-derived complement. Cell Reports, 6 (6), 1085-1095. doi: 10.1016/j.celrep.2014.02.014
Nishimura, Masato, Jung, Eun-Jung, Shah, Maitri Y., Lu, Chunhua, Spizzo, Riccardo, Shimizu, Masayoshi, Han, Hee Dong, Ivan, Cristina, Rossi, Simona, Zhang, Xinna, Nicoloso, Milena S., Wu, Sherry Y., Almeida, Maria Ines, Bottsford-Miller, Justin, Pecot, Chad V., Zand, Behrouz, Matsuo, Koji, Shahzad, Mian M., Jennings, Nicholas B., Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Sood, Anil K. and Calin, George A. (2013). Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment. Cancer Discovery, 3 (11), 1302-1315. doi: 10.1158/2159-8290.CD-13-0159
Kim, Hyun Seok, Mendiratta, Saurabh, Kim, Jiyeon, Pecot, Chad Victor, Larsen, Jill E., Zubovych, Iryna, Seo, Bo Yeun, Kim, Jimi, Eskiocak, Banu, Chung, Hannah, McMillan, Elizabeth, Wu, Sherry, De Brabander, Jef, Komurov, Kakajan, Toombs, Jason E., Wei, Shuguang, Peyton, Michael, Williams, Noelle, Gazdar, Adi F., Posner, Bruce A., Brekken, Rolf A., Sood, Anil K., Deberardinis, Ralph J., Roth, Michael G., Minna, John D. and White, Michael A. (2013). Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell, 155 (3), 552-566. doi: 10.1016/j.cell.2013.09.041
Kang, Yu, Hu, Wei, Ivan, Cristina, Dalton, Heather J., Miyake, Takahito, Pecot, Chad V., Zand, Behrouz, Liu, Tao, Huang, Jie, Jennings, Nicholas B., Rupaimoole, Rajesha, Taylor, Morgan, Pradeep, Sunila, Wu, Sherry Y., Lu, Chunhua, Wen, Yunfei, Huang, Jianfei, Liu, Jinsong and Sood, Anil K. (2013). Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. JNCI-Journal of the National Cancer Institute, 105 (19), 1485-1495. doi: 10.1093/jnci/djt210
Pecot, Chad V., Rupaimoole, Rajesha, Yang, Da, Akbani, Rehan, Ivan, Cristina, Lu, Chunhua, Wu, Sherry, Han, Hee-Dong, Shah, Maitri Y., Rodriguez-Aguayo, Cristian, Bottsford-Miller, Justin, Liu, Yuexin, Kim, Sang Bae, Unruh, Anna, Gonzalez-Villasana, Vianey, Huang, Li, Zand, Behrouz, Moreno-Smith, Myrthala, Mangala, Lingegowda S., Taylor, Morgan, Dalton, Heather J., Sehgal, Vasudha, Wen, Yunfei, Kang, Yu, Baggerly, Keith A., Lee, Ju-Seog, Ram, Prahlad T., Ravoori, Murali K., Kundra, Vikas ... Sood, Anil K. (2013). Tumour angiogenesis regulation by the miR-200 family. Nature Communications, 4 (1) 2427. doi: 10.1038/ncomms3427
Masiero, Massimo, Simões, Filipa Costa, Han, Hee Dong, Snell, Cameron, Peterkin, Tessa, Bridges, Esther, Mangala, Lingegowda S., Wu, Sherry Yen-Yao, Pradeep, Sunila, Li, Demin, Han, Cheng, Dalton, Heather, Lopez-Berestein, Gabriel, Tuynman, Jurriaan B., Mortensen, Neil, Li, Ji-Liang, Patient, Roger, Sood, Anil K., Banham, Alison H., Harris, Adrian L. and Buffa, Francesca M. (2013). A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Cancer Cell, 24 (2), 229-241. doi: 10.1016/j.ccr.2013.06.004
McCaskill, Jana, Singhania, Richa, Burgess, Melinda, Allavena, Rachel, Wu, Sherry, Blumenthal, Antje and McMillan, Nigel A. J. (2013). Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA. Molecular Therapy - Nucleic Acid, 2 (1) e96, e96. doi: 10.1038/mtna.2013.22
Hua, Susan and Wu, Sherry Y. (2013). The use of lipid-based nanocarriers for targeted pain therapies. Frontiers in Pharmacology, 4. doi: 10.3389/fphar.2013.00143
Wu, Sherry Y. and Sood, Anil K. (2012). New roles opined for OPCML. Cancer Discovery, 2 (2), 115-116. doi: 10.1158/2159-8290.CD-11-0356
Khairuddin, Norliana, Gantier, Michael P., Blake, Stephen J., Wu, Sherry Y., Behlke, Mark A., Williams, Bryan R. G. and McMillan, Nigel A. J. (2012). siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo. Immunology and Cell Biology, 90 (2), 187-196. doi: 10.1038/icb.2011.19
Wu, Sherry Y., Chang, Hsin-I, Burgess, Melinda and McMillan, Nigel A. J. (2011). Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system. Journal of Controlled Release, 155 (3), 418-426. doi: 10.1016/j.jconrel.2011.02.002
Singhania, Akul, Wu, Sherry Y. and McMillan, Nigel A. J. (2011). Effective delivery of PEGylated siRNA-containing Lipoplexes to extraperitoneal tumours following intraperitoneal administration. Journal of Drug Delivery, 2011, 192562.1-192562.7. doi: 10.1155/2011/192562
Wu, S. Y., Singhania, A., Burgess, M., Putral, L. N., Kirkpatrick, C., Davies, N. M. and McMillan, N. A. J. (2011). Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models. Gene Therapy, 18 (1), 14-22. doi: 10.1038/gt.2010.113
Wu, SY and McMillan, NAJ (2009). Lipidic Systems for In Vivo siRNA Delivery. AAPS JOURNAL, 11 (4), 639-652. doi: 10.1208/s12248-009-9140-1
Wu, Sherry Y., Putral, Lisa N., Liang, Mingtao, Chang, Hsin-I, Davies, Nigel M. and McMillan, Nigel A.J. (2009). Development of a novel method for formulating stable siRNA-loaded lipid particles for In vivo use. Pharmaceutical Research, 26 (3), 512-522. doi: 10.1007/s11095-008-9766-1

Conference Papers

Aland, Claire, Oancea, Iulia, Midwinter, Mark, Pillai, Suja, Manchadi, Mary-Louise, Reichelt, Melissa and Wu, Sherry (2022). Using action learning to develop a model for inclusive teaching in a COVID-split cohort. 26th Annual International Association for Medical Science Educators, Denver, CO, United States, 4-7 June 2022.
Stur, Elaine, Dal Molin, Graziela Zibetti, Wu, Sherry, Baggerly, Keith, Tworoger, Shelley, Levine, Douglas, Karlan, Beth, Moore, Kathleen, Lutgendorf, Susan and Sood, Anil (2020). Molecular analysis of short- vs. long-term ovarian cancer survivors. AACR Special Conference on Advances in Ovarian Cancer Research, Atlanta, GA United States, 13-16 September 2019. Philadelphia, PA United States: American Association for Cancer Research.
Wu, Sherry, Yang, Xianbin, Egli, Martin, Ghaupure, Kshipra, Hatakeyama, Hiroto, McGuire, Michael, Rupaimoole, Rajesha, Miyake, Takahito, Taylor, Morgan, Pradeep, Sunila, Nagaraja, Archana, Sierant, Malgorzata, Singhania, Richa, Rodriguez-Aguayo, Cristian, McMillan, Nigel, Lopez-Berestein, Gabriel, Ram, Prahlad, Nawrot, Barbara and Sood, Anil K. (2014). Evoking potent RNAi response using novel 2 '-OMe-phosphorodithioated modified siRNAs. 105th Annual Meeting of the American Association for Cancer Research (AACR), San Diego, CA United States, 05-09 April 2014. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2014-1406