Book Chapter
Huang, Lili, Huang, Zhengxiang, Chen, Yang and Chen, Chen (2020). Neuroendocrine and metabolic regulation of plasma growth hormone secretory profiles. Neurosecretion: secretory mechanisms. (pp. 195-218) edited by Jose R. Lemos, Govindan Dayanithi. Cham, Switzerland: Springer Nature Switzerland. doi: 10.1007/978-3-030-22989-4_10
Journal Articles
Chen, Xiaolin, Xiao, Zhuoni, Cai, Yuli, Huang, Lili and Chen, Chen (2022). Hypothalamic mechanisms of obesity-associated disturbance of hypothalamic–pituitary–ovarian axis. Trends in Endocrinology and Metabolism, 33 (3), 206-217. doi: 10.1016/j.tem.2021.12.004
Lu, Xuehan, Huang, Lili, Huang, Zhengxiang, Feng, Dandan, Clark, Richard J. and Chen, Chen (2021). LEAP-2: an emerging endogenous ghrelin receptor antagonist in the pathophysiology of obesity. Frontiers in Endocrinology, 12 717544, 717544. doi: 10.3389/fendo.2021.717544
Huang, Zhengxiang, Lu, Xuehan, Huang, Lili, Chen, Yang, Zhang, Chunhong, Veldhuis, Johannes D. and Chen, Chen (2021). Suppression of hyperinsulinemia restores growth hormone secretion and metabolism in obese mice. Journal of Endocrinology, 250 (3), 105-116. doi: 10.1530/JOE-20-0616
Wang, Weihao, Huang, Zhengxiang, Huang, Lili, Tan, Chunlu, Chen, Wanlin, Roelfsema, Ferdinand, Chen, Chen and Guo, Lixin (2021). Rotating day and night disturb growth hormone secretion profiles, body energy metabolism and insulin levels in mice. Neuroendocrinology, 112 (5), 1-12. doi: 10.1159/000518338
Wang, Weihao, Huang, Zhengxiang, Huang, Lili, Gao, Lyn, Cui, Ling, Cowley, Michael, Guo, Lixin and Chen, Chen (2021). Time-restricted feeding restored insulin-growth hormone balance and improved substrate and energy metabolism in MC4RKO obese mice. Neuroendocrinology, 112 (2), 174-185. doi: 10.1159/000515960
Tong, Yue, Xu, Sai, Huang, Lili and Chen, Chen (2021). Obesity and insulin resistance: Pathophysiology and treatment. Drug Discovery Today, 27 (3), 822-830. doi: 10.1016/j.drudis.2021.11.001
Huang, Lili, Gao, Lin and Chen, Chen (2021). Role of medium-chain fatty acids in healthy metabolism: a clinical perspective. Trends in Endocrinology and Metabolism, 32 (6), 351-366. doi: 10.1016/j.tem.2021.03.002
Huang, Zhengxiang, Lu, Xuehan, Huang, Lili, Zhang, Chunhong, Veldhuis, Johannes D., Cowley, Michael A. and Chen, Chen (2021). Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice. The FASEB Journal, 35 (1) e21269, e21269. doi: 10.1096/fj.202001924rr
Huang, Zhengxiang, Wang, Weihao, Huang, Lili, Guo, Lixin and Chen, Chen (2020). Suppression of insulin secretion in the treatment of obesity: a systematic review and meta-analysis. Obesity, 28 (11), 2098-2106. doi: 10.1002/oby.22955
Huang, Zhengxiang, Huang, Lili, Waters, Michael J. and Chen, Chen (2020). Insulin and growth hormone balance: implications for obesity. Trends in Endocrinology and Metabolism, 31 (9), 642-654. doi: 10.1016/j.tem.2020.04.005
Kaur, Harleen, Muhlhausler, Beverly S., Sim, Pamela Su-Lin, Page, Amanda J., Li, Hui, Nunez-Salces, Maria, Clarke, Georgia S., Huang, Lili, Wilson, Rebecca L., Veldhuis, Johannes D., Chen, Chen, Roberts, Claire T. and Gatford, Kathryn L. (2020). Pregnancy, but not dietary octanoic acid supplementation, stimulates the ghrelin-pituitary growth hormone axis in mice. Journal of Endocrinology, 245 (2), 327-342. doi: 10.1530/JOE-20-0072
Huang, Zhengxiang, Huang, Lili, Wang, Chengjian, Zhu, Shanli, Qi, Xinzhou, Chen, Yang, Zhang, Yanjun, Cowley, Michael, Veldhuis, Johannes D and Chen, Chen (2020). Dapagliflozin restores insulin and growth hormone secretion in obese mice. Journal of Endocrinology, 245 (1), 1-12. doi: 10.1530/JOE-19-0385
Huang, Lili, Huang, Zhengxiang and Chen, Chen (2019). Rhythmic growth hormone secretion in physiological and pathological conditions: lessons from rodent studies. Molecular and Cellular Endocrinology, 498 110575, 110575. doi: 10.1016/j.mce.2019.110575
Chen, Yang, Huang, Lili, Qi, Xinzhou and Chen, Chen (2019). Insulin receptor trafficking: consequences for insulin sensitivity and diabetes. International Journal of Molecular Sciences, 20 (20) 5007, 5007. doi: 10.3390/ijms20205007
Mosa, Rasha, Huang, Lili, Li, Hongzhuo, Grist, Michael, LeRoith, Derek and Chen, Chen (2018). Long-term treatment with the ghrelin receptor antagonist [D-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 314 (1), R71-R83. doi: 10.1152/ajpregu.00157.2017
Xu, Chun, Lei, Chang, Huang, Lili, Zhang, Jun, Zhang, Hongwei, Song, Hao, Yu, Meihua, Wu, Yeda, Chen, Chen and Yu, Chengzhong (2017). Glucose-responsive nanosystem mimicking the physiological insulin secretion via an enzyme-polymer layer-by-layer coating strategy. Chemistry of Materials, 29 (18), 7725-7732. doi: 10.1021/acs.chemmater.7b01804
Mosa, Rasha, Huang, Lili, Wu, Yeda, Fung, Chungyan, Mallawakankanamalage, Oshini, LeRoith, Derek and Chen, Chen (2017). Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice. Endocrinology, 158 (10), 3174-3187. doi: 10.1210/en.2017-00168
Gatford, Kathryn L., Muhlhausler, Beverly S., Huang, Lili, Sim, Pamela Su-Lin, Roberts, Claire T., Velhuis, Johannes D. and Chen, Chen (2017). Rising maternal circulating GH during murine pregnancy suggests placental regulation. Endocrine Connections, 6 (4), 260-266. doi: 10.1530/EC-17-0032
Chen, Xiaolin, Huang, Lili , Tan, Hwee Y., Li, Hongzhuo, Wan, Ying, Cowley, Michael, Veldhuis, Johannes D. and Chen, Chen (2017). Deficient melanocortin-4 receptor causes abnormal reproductive neuroendocrine profile in female mice. Reproduction, 153 (3), 267-276. doi: 10.1530/REP-16-0341
Tan, H. Y., Steyn, F. J., Huang, L., Cowley, M., Veldhuis, J. D. and Chen, C. (2016). Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone. Journal of Physiology, 594 (24), 7309-7326. doi: 10.1113/JP272770
Ngo, S. T., Steyn, F. J., Huang, L., Mantovani, S., Pfluger, C. M. M., Woodruff, T. M., O'Sullivan, J. D., Henderson, R. D. and McCombe, P. A. (2015). Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 357 (1-2), 22-27. doi: 10.1016/j.jns.2015.06.053
Huang, Lili, Tan, Hwee Y., Fogarty, Matthew J., Andrews, Zane B., Veldhuis, Johannes D., Herzog, Herbert, Steyn, Frederik J. and Chen, Chen (2014). Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state. Journal of Neuroscience, 34 (49), 16309-16319. doi: 10.1523/JNEUROSCI.4622-13.2014
Steyn, F. J., Xie, T. Y., Huang, L., Ngo, S. T., Veldhuis, J. D., Waters, M. J. and Chen, C. (2013). Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain. Journal of Endocrinology, 218 (2), 233-244. doi: 10.1530/JOE-13-0084
Tan, H. Y., Huang, L., Simmons, D., Veldhuis, J. D., Steyn, F. J. and Chen, C. (2013). Hypothalamic distribution of somatostatin mRNA expressing neurones relative to pubertal and adult changes in pulsatile growth hormone secretion in mice. Journal of Neuroendocrinology, 25 (10), 910-919. doi: 10.1111/jne.12078
Huang, L., Steyn, F. J., Tan, H. Y., Xie, T. Y., Veldhuis, J. D., Ngo, S. T. and Chen, C. (2012). The decline in pulsatile GH secretion throughout early adulthood in mice is exacerbated by dietary-induced weight gain. Endocrinology, 153 (9), 4380-4388. doi: 10.1210/en.2012-1178
Steyn, F. J., Leong, J. W., Huang, L., Tan, H. Y., Xie, T. Y., Nelson, C., Waters, M. J., Veldhuis, J. D., Epelbaum, J. and Chen, C. (2012). GH does not modulate the early fasting-induced release of free fatty acids in mice. Endocrinology, 153 (1), 273-282. doi: 10.1210/en.2011-1681
Steyn, F. J., Huang, L., Ngo, S. T., Leong, J. W., Tan, H. Y., Xie, T. Y., Parlow, A. F., Veldhuis, J. D., Waters, M. J. and Chen, C. (2011). Development of a method for the determination of pulsatile growth hormone secretion in mice. Endocrinology, 152 (8), 3165-3171. doi: 10.1210/en.2011-0253
Conference Papers
Gatford, Kathryn L., Muhlhausler, Beverly S., Sim, Pamela S-L, Roberts, Claire T., Veldhuis, Johannes D., Huang, Lili and Chen, Chen (2017). Pulsatile GH profiles in the pregnant mouse reveal marked increases in circulating GH and GH secretion between early and mid-pregnancy. Endocrine Society of Australia Annual Scientific Meeting 2016, Adelaide Convention Centre, Adelaide, 21-24 August 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Chen, C., Tan, H. Y., Huang, L., Xie, T., Steyn, F. J. and Veldhuis, J. D. (2013). Growth hormone and obesity: a physiological response to an unhealthy condition. 4th Meeting of the Australia-Chinese-Association-for-Biomedical-Sciences-Inc (ACABS 2013), Hangzhou, China, 10-13 October 2013. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/1440-1681.12170_4
Thesis
Huang, Lili (2013). Modulation of pulsatile growth hormone (GH) secretion in positive and negative energy balance in the mouse. PhD Thesis, School of Biomedical Sciences, The University of Queensland.