Head of Laboratory

Stuart Mazzone and Simon Phipps

Location

MacGregor Building, Level 5

Staff

  • Dr Sean Yang
  • Dr Vivian Zhang

Students

  • Alice McGovern - PhD
  • Ayaka Ando PhD
  • Jennifer Leech PhD
  • Jason Lynch PhD
  • Zhixuan (Ken) Loh PhD
  • Jaisy Eacharath PhDKhang Duong PhD
  • Ashik Ullah - PhD
  • Ariel Woo Hons
  • Tracy Tongol Hons
  • Matt Rogers Hons
  • Zenglong (Matt) Zhang Hons
  • Rhiannon Werder Hons

Research

Innate immune processes that underlie the pathogenesis of allergic asthma, emphysema and bronchiolitis

Dr Phipps research program employs both in vitro and in vivo model systems to elucidate the relationship between innate pattern recognition receptors (PRR) and the programming of aberrant immunologic processes that underlie the development of distinct endophenotypes of asthma, emphysema and virus-associated bronchiolitis. The group also has an interest in understanding the cellular and molecular mechanisms that contribute to bronchus-associated lymphoid tissue (BALT) formation and the contribution of BALT to host defense.

Neurobiology of respiratory defense in health and disease

Dr Mazzones research program employs a wide variety of in vitro, in vivo and human experimental systems to understand the neurobiology of airway protective reflexes and their alteration in pulmonary diseases. Our primary aims are to understand the activation properties of airway sensory neurons and to map their circuitries in the brain in both healthy and disease models. We also have an interest in understanding how innate inflammatory molecules expressed by airway neurons are involved in virally-mediated nerve dysfunction.

Full list of publications

Research Support (last 5 years)

2013 - 2015. Mazzone, Farrell, Egan. A$443,639.
National Health and Medical Research Council Project Grant. Neural dysfunction in chronic cough.

2012 - 2013. Farrell, Mazzone. A$155,829.
Cystic Fibrosis Australia. Brain responses to airway irritation in people with CF.

2012 - 2014. S.Phipps, J.Upham. A$533,675.
National Health and Medical Research Council Project Grant. Defective toll-like receptor 7 signalling underlies the inception and exacerbations of asthma.

2012 - 2015. Mazzone. A$452,568.
National Health and Medical Research Council Career Development Fellowship Level 2. Regulation of airway defensive reflexes.

2012 - 2014. M.Smythe, J.Flanigan, S.Phipps. A$417,340
National Health and Medical Research Council Development Grant Towards new therapeutic treatments for asthma.
 
2010 - 2012. S.Phipps, J.Simpson. A$654,875.
National Health and Medical Research Council Project Grant. The pathogenesis of distinct endophenotypes of asthma is underpinned by the collaborative activation of specific PRRs.
 
2009 - 2011 Mazzone. A$432,000.
National Health and Medical Research Council Project Grant. Identification of brain regions involved in the regulation of coughing.
 
2008 - 2010. S.Phipps. A$392,125.
National Health and Medical Research Council Project Grant. Pneumovirus infection in infancy affects the development of life-long adaptive immunity.
 
2008 - 2011 Mazzone. A$457,500.
National Health and Medical Research Council RD Wright Fellowship Regulation of airway defensive reflexes.

Links