Our group is dedicated to uncovering the intricate molecular and systems-level mechanisms that drive infectious and neurodegenerative diseases using multiscale mathematical modelling and advanced imaging techniques to engineer new treatment strategies.

Our research areas

Infectious and neurodegenerative diseases

Our research focuses on infectious diseases caused by viruses such as hepatitis C, SARS-CoV-2, and respiratory syncytial virus, as well as neurodegenerative diseases such as Alzheimer’s disease and frontotemporal dementia. We employ advanced imaging techniques, such as super-resolution microscopy, to investigate the underlying pathomechanisms. We also develop multiscale mathematical models integrating phenomena from molecular to human population levels to understand treatment failures and predict strategies for improving outcomes.

Our group uses a combination of computational and quantitative experimentation techniques including:

  • Cell cultures: Primary mouse neurons and non-neuronal cells such as neuroblastoma cells
  • Animal models: Mouse models of Alzheimer’s disease
  • Super-resolution microscopy techniques: sptPALM, uPAINT and dSTORM
  • Biochemical methods: Western blotting, PCR, and ELISA
  • Mathematical modelling: Quantitative systems pharmacology, pharmacokinetics, pharmacometrics, viral dynamics, hidden Markov modelling, and systems biology and network modelling

View full list of publications on eSpace

Selected publications

Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Amor, Rumelo, Sibarita, Jean‐Baptiste and Götz, Jürgen (2022). Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO Journal, 41 (19) e111265, 1-16. doi: 10.15252/embj.2022111265

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Sir William Macgregor Building (64), Level 5, Room 511

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