Our laboratory is part of the School of Biomedical Sciences at the University of Queensland and the Center for Physiology and Pharmacology at the Medical University of Vienna, Austria. 

Our main research interests are:

  • Chemical Pharmacology and Drug Discovery
    • Immunosuppressive cyclic peptides: in vitro signalling und preclinical applications
    • Protein-protein interaction of transmembrane
    • Bioactive peptides from nature: isolation, analysis and pharmacological activity
    • Neuropeptides from invertebrates: ligand-receptor interactions and evolution, functional characterisation, modulation of human receptors
  • Peptidomics
    • Discovery and characterization of nature-derived peptides nature using mass spectrometry

Gruber Lab overview


Lab head

Postdoctoral scientist

Thell K, et al. (2016) Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America 113: 3960-65. link

Hellinger R, et al. (2015)  Peptidomics of circular cysteine-rich plant peptides: Analysis of the diversity of cyclotides from Viola tricolor by transcriptome and proteome mining. Journal of Proteome Research 14(11): 4851-62. link

Koehbach J, et al. (2013) Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America 110: 21183-8. link

Bergmayr C, et al. (2013) Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor. Journal of Biological Chemistry 288: 28831-44. link

Gründemann C, et al. (2013) Cyclotides suppress human T-lymphocyte proliferation by an interleukin 2-dependent mechanism. PLoS ONE 8(6): e68016. link

Gruber CW & Muttenthaler M. (2012) Discovery of defense- and neuropeptides in social ants by genome-mining. PLoS ONE 7(3): e32559. link

Gruber CW, Muttenthaler M, Freissmuth M. (2010) Structure-based combinatorial peptide design to target GPCRs. Current Pharmaceutical Design 16: 3071-88. link

Gruber CW, et al. (2008). Distribution and evolution of circular miniproteins in flowering plants. Plant Cell 20: 2471-83. link


A list of all publications can be found via PubMed or GoogleScholar.

Find out more about our research environment and how to apply to do a short or long-term research project with us.