Gruber Lab - Chemical pharmacology
Our laboratory is part of the School of Biomedical Sciences at the University of Queensland and the Center for Physiology and Pharmacology at the Medical University of Vienna, Austria.
Our main research interests are:
- Chemical Pharmacology and Drug Discovery
- Immunosuppressive cyclic peptides: in vitro signalling und preclinical applications
- Protein-protein interaction of transmembrane
- Bioactive peptides from nature: isolation, analysis and pharmacological activity
- Neuropeptides from invertebrates: ligand-receptor interactions and evolution, functional characterisation, modulation of human receptors
- Peptidomics
- Discovery and characterization of nature-derived peptides nature using mass spectrometry
Thell K, et al. (2016) Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America 113: 3960-65. link
Hellinger R, et al. (2015) Peptidomics of circular cysteine-rich plant peptides: Analysis of the diversity of cyclotides from Viola tricolor by transcriptome and proteome mining. Journal of Proteome Research 14(11): 4851-62. link
Koehbach J, et al. (2013) Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America 110: 21183-8. link
Bergmayr C, et al. (2013) Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor. Journal of Biological Chemistry 288: 28831-44. link
Gründemann C, et al. (2013) Cyclotides suppress human T-lymphocyte proliferation by an interleukin 2-dependent mechanism. PLoS ONE 8(6): e68016. link
Gruber CW & Muttenthaler M. (2012) Discovery of defense- and neuropeptides in social ants by genome-mining. PLoS ONE 7(3): e32559. link
Gruber CW, Muttenthaler M, Freissmuth M. (2010) Structure-based combinatorial peptide design to target GPCRs. Current Pharmaceutical Design 16: 3071-88. link
Gruber CW, et al. (2008). Distribution and evolution of circular miniproteins in flowering plants. Plant Cell 20: 2471-83. link
A list of all publications can be found via PubMed or GoogleScholar.
- Dr. Markus Muttenthaler (Institute for Molecular Bioscience, Australia)
- PD Dr. Carsten Gründemann (University Hospital Freiburg, Germany)
- Dr. Richard Clark (University of Queensland, Australia)
- Prof. Sylvia Cremer (IST Austria)
- Assoc. Prof. Priv.-Doz. Dr. Gernot Schabbauer (Medical University of Vienna, Austria)
- Prof. David Craik (Institute for Molecular Bioscience, Australia)
- Prof. Christian Becker (University of Vienna, Austria)
- Assoc. Prof. Ulf Göransson (University of Uppsala, Sweden)
- Prof. Sassan Asgari (University of Queensland, Australia)
Find out more about our research environment and how to apply to do a short or long-term research project with us.