School of Biomedical Sciences

Launikonis Lab - Publications

  1. Home
  2. Research
  3. Research groups
  4. Muscle research

Lamboley CR, Pearce L, Seng C, Meizoso-Huesca A, Singh DP, Frankish BP, Kaura V, Lo HP, Ferguson C, Allen PD, Hopkins PM, Parton RG, Murphy RM, van der Poel C, Barclay CJ, Launikonis BS (2021). Ryanodine receptor leak triggers fibre Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances 7, eabi7166.

Meizoso-Huesca A, Launikonis BS (2021). The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle. J Gen Physiol 153, e202012747.

Rebbeck RT, Singh DP, Janicek KA, Bers DM, Thomas DD, Launikonis BS & Cornea RL(2020). RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. Sci Rep 10(1):1791.

Barclay CJ & Launikonis BS (2019). Components of heat activation in skeletal muscle. J Muscle Res Cell Mot doi: 10.1007/s10974-019-09547-5.

Koenig X, Choi RH, Schicker K, Singh DP, Hilber K & Launikonis BS (2019). Mechanistic insights into store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle. BBA - Molecular Cell Research 1866, 1239-1248. (Special Issue: European Calcium Society Meeting).

Cully TR, Choi RH, Bjorksten AR, Stephenson DG, Murphy RM & Launikonis BS (2018). Junctional membrane Ca2+-dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation. Proc Natl Acad Sci USA. 115, 8215-8220.

Koenig X, Choi RH & Launikonis BS (2018). Store-operated Ca2+ entry is activated by every action potential in skeletal muscle. Communications Biology 1, 31.

Launikonis BS, Cully TR, Csernoch L & Stephenson DG (2018). NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat. J Gen Physiol 150, 95-110.

Choi RH, Koenig X & Launikonis BS (2017). Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proc Natl Acad Sci USA 114, 4811-4815.

Bakker AJ, Cully TR, Wingate C, Barclay CJ & Launikonis BS (2017). Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. J Gen Physiol 149, 323-334.

Cully TR, Murphy RM, Roberts L, Raastad T, Fassett RG, Coombes JS, Jayasinghe ID & Launikonis BS (2017). Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise. Nat Commun 8, 14266. 

Cully, Tanya R., Edwards, Joshua N., Murphy, Robyn M. and Launikonis, Bradley S. (2016) A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres. Journal of Physiology, 594 11: 2795-2810. doi:10.1113/JP271658

Cully, Tanya R. and Launikonis, Bradley S. (2016) Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle. American Journal of Physiology: Cell Physiology, 310 8: C673-C680. doi:10.1152/ajpcell.00366.2015

Cully, Tanya R., Edwards, Joshua N. and Launikonis, Bradley S. (2014) Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle. Journal of Physiology, 592 17: 3727-3746. doi:10.1113/jphysiol.2014.274274

Jayasinghe, Isuru D., Munro, Michelle, Baddeley, David, Launikonis, Bradley S. and Soeller, Christian (2014) Observation of the molecular organization of calcium release sites in fast- and slowtwitch skeletal muscle with nanoscale imaging. Journal of the Royal Society Interface, 11 99: . doi:10.1098/rsif.2014.0570

Jayasinghe, Isuru D. and Launikonis, Bradley S. (2013) Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle. Journal of Cell Science, 126 17: 4048-4058. doi:10.1242/jcs.131565

Jayasinghe, Isuru D., Lo, Harriet P., Morgan, Garry P., Baddeley, David, Parton, Robert G., Soeller, Christian and Launikonis, Bradley S. (2013) Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers. Biophysical Journal, 104 11: L19-L21. doi:10.1016/j.bpj.2013.04.029

Cully, Tanya R. and Launikonis, Bradley S. (2013) Store-operated Ca2+ entry is not required for store refilling in skeletal muscle. Clinical and Experimental Pharmacology and Physiology, 40 5: 338-344. doi:10.1111/1440-1681.12078

Cully, Tanya R., Edwards, Joshua N., Friedrich, Oliver, Stephenson, D. George, Murphy, Robyn M. and Launikonis, Bradley S. (2012) Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca2+ signaling in dystrophic mdx mouse muscle.. American Journal of Physiology - Cell Physiology, 303 5: C567-C576. doi:10.1152/ajpcell.00144.2012

Edwards, Joshua N., Cully, Tanya R., Shannon, Thomas R., Stephenson, D. George and Launikonis, Bradley S. (2012) Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy. Journal of Physiology, 590 3: 475-491. doi:10.1113/jphysiol.2011.221796

Edwards, Joshua N., Blackmore, Daniel G., Gilbert, Daniel F., Murphy, Robyn M. and Launikonis, Bradley S. (2011) Store-operated calcium entry remains fully functional in aged mouse skeletal muscle despite a decline in STIM1 protein expression. Aging Cell, 10 4: 675-685. doi:10.1111/j.1474-9726.2011.00706.x

Launikonis, Bradley S., Murphy, Robyn M. and Edwards, Joshua N. (2010) Toward the roles of store-operated Ca(2+) entry in skeletal muscle. Pflugers Archiv - European Journal of Physiology, 460 5: 813-823. doi:10.1007/s00424-010-0856-7

Edwards, Joshua N., Friedrich, Oliver, Cully, Tanya R., von Wegner, Frederic, Murphy, Robyn M. and Launikonis, Bradley S. (2010) Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle. American Journal of Physiology: Cell Physiology, 299 1: C42-C50. doi:10.1152/ajpcell.00524.2009

Edwards, Joshua N., Murphy, Robyn M., Cully, Tanya R., von Wegner, Frederic, Friedrich, Oliver and Launikonis, Bradley S. (2010) Ultra-rapid activation and deactivation of store-operated Ca2+ entry in skeletal muscle. Cell Calcium, 47 5: 458-467. doi:10.1016/j.ceca.2010.04.001

Launikonis, Bradley S., Stephenson, D. George and Friedrich, Oliver (2009) Rapid Ca2+ flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle. Journal of Physiology, 587 10: 2299-2312. doi:10.1113/jphysiol.2009.168682

Edwards, Joshua N. and Launikonis, Bradley S. (2008) The accessibility and interconnectivity of the tubular system network in toad skeletal muscle. The Jounal of Physiology, 586 21: 5077-5089. doi:10.1113/jphysiol.2008.155127

Launikonis, BS and Rios, E (2007) Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle. Journal of Physiology-london, 583 1: 81-97. doi:10.1113/jphysiol.2007.135046

Launikonis, B. S., Zhou, J. S., Royer, L., Shannon, T. R., Brum, G. and Rios, E. (2006) Depletion "skraps" and dynamic buffering inside the cellular calcium store. Proceedings of The National Academy of Sciences of The United States of America, 103 8: 2982-2987. doi:10.1073/pnas.0511252103