Steyn Group - Publications
2021
Holdom CJ, et al. (2021). Low plasma hyaluronan is associated with faster functional decline in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. doi: 10.1080/21678421.2021.1918721
McGill RB, et al. (2021). Monocyte CD14 and HLA-DR expression increases with disease duration and severity in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 1-8. doi: 10.1080/21678421.2021.1964531
Holdom CJ, et al. (2021). Venous creatinine as a biomarker for loss of fat‐free mass and disease progression in patients with Amyotrophic Lateral Sclerosis. European Journal of Neurology ene.15003. doi: 10.1111/ene.15003
Sidhom SS, et al. (2021). 17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 76 (5), 778-785. doi: 10.1093/gerona/glaa215
Restuadi R, et al. (2021). Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia. European Journal of Human Genetics, 1-8. doi: 10.1038/s41431-021-00885-y
Tracey TJ, et al. The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosis. Semin Cell Dev Biol 2021;112:69-81.
Tefera TW, et al. CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target? Cell Biosci 2021;11:14.
Ongaro L, et al. Development of a Highly Sensitive ELISA for Measurement of FSH in Serum, Plasma, and Whole Blood in Mice. Endocrinology 2021;162.
Ngo ST, et al. Ghrelin as a treatment for amyotrophic lateral sclerosis. J Neuroendocrinol 2021:e12938.
Nabais MF, et al. Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biol 2021;22:90.
Holdom C, et al. Fluid biomarkers of amyotrophic lateral sclerosis. In: Peplow P, Martinez B, Gennarelli T, eds. Towards translating biomarker research of neurodegenerative diseases into clinical practice: Springer Nature, 2021.
Ahmed RA, et al. The Human Hypothalamus: Hypothalamus and weight loss in amyotrophic lateral sclerosis. Handbook of Clinical Neurology, 4th Edition ed. 2021.
2020
Steyn FJ, et al. Prognostic value of weight loss in patients with amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2020;91:813.
Steyn FJ, et al. Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis. Brain Commun 2020;2:fcaa154.
Steyn FJ, et al. Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis. bioRxiv 2020;2020.04.03.021238.
Sidhom S, et al. 17alpha-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner. J Gerontol A Biol Sci Med Sci 2020.
Scaricamazza S, et al. Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1(G93A) Mice Predates Disease Onset and Is A Promising Therapeutic Target. iScience 2020;23:101087.
Ngo ST, et al. Progression and survival of patients with motor neuron disease relative to their fecal microbiota. Amyotroph Lateral Scler Frontotemporal Degener 2020;21:549-562.
Nabais MF, et al. Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. Npj Genom Med 2020;5:10.
McGill RB, et al. Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis. Brain Commun 2020;2:fcaa013.
Joustra SD, et al. Response to Letter to the Editor: "IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction". J Clin Endocrinol Metab 2020;105.
Joustra SD, et al. IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocr Metab 2020;105:E70-E84.
Iacoangeli A, et al. Genome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus Is Associated with ALS and Links Weight Loss to the Disease Genetics. Cell Rep 2020;33:108323.
2019
Ngo ST, et al. Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis. Amyotroph Lat Scl Fr 2019;20:497-505.
Nabizadeh JA, et al. C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma. Faseb J 2019;33:11060-11071.
Nabizadeh J, et al. Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma. Eur J Immunol 2019;49:174-174.
McCombe PA, et al. Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction. J Neurol Neurosur Ps 2019;90:952-954.
McCombe PA, et al. Gut microbiota in ALS: possible role in pathogenesis? Expert Rev Neurother 2019;19:785-805.
Kirk SE, et al. Biomarkers of Metabolism in Amyotrophic Lateral Sclerosis. Front Neurol 2019;10.
Tracey TJ, et al. Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease. Front Mol Neurosci 2018;11.
2018
Steyn FJ, et al. 17 alpha-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell 2018;17.
Steyn FJ, et al. Hypermetabolism in ALS is associated with greater functional decline and shorter survival. J Neurol Neurosur Ps 2018;89:1016-1023.
2017
Varamini P, et al. Development of New Gonadotropin-Releasing Hormone-Modified Dendrimer Platforms with Direct Antiproliferative and Gonadotropin Releasing Activity. J Med Chem 2017;60:8309-8320.
Varamini P, et al. New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency. Int J Pharm 2017;521:327-336.
Stout MB, et al. 17 alpha-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. J Gerontol a-Biol 2017;72:3-15.
Steyn FJ, et al. Comparison of Faecal Microbe Diversity between Motor Neurone Disease (Mnd) and Control Participants. J Neurol Neurosur Ps 2017;88.
Steyn FJ, et al. Endocrine rhythms of growth hormone release: Insights from animal studies. Best Pract Res Cl En 2017;31:521-533.
Steyn FJ. Growth Hormone Releasing Hormone. Encyclopedia of Signaling Molecules, 2nd edition: Springer, 2017.
Spiers JG, et al. Noninvasive assessment of altered activity following restraint in mice using an automated physiological monitoring system. Stress 2017;20:59-67.
Ngo ST, et al. Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions. Degener Neurol Neuro 2017;7:95-108.
Kirk SE, et al. Restraint stress increases prolactin-mediated phosphorylation of signal transducer and activator of transcription 5 in the hypothalamus and adrenal cortex in the male mouse. J Neuroendocrinol 2017;29.
Ioannides ZA, et al. Predictions of resting energy expenditure in amyotrophic lateral sclerosis are greatly impacted by reductions in fat free mass. Cogent Medicine 2017;4:1343000.
Ioannides ZA, et al. Anthropometric measures are not accurate predictors of fat mass in ALS. Amyotroph Lat Scl Fr 2017;18:486-491.
Ioannides ZA, et al. The Risk of Overestimating Fatness in Motor Neurone Disease: Longitudinal Assessments of Body Composition. J Neurol Neurosur Ps 2017;88.
Ioannides ZA, et al. Hypermetabolism in Motor Neurone Disease Is Associated with a Greater Functional Decline but Not Weight Loss. J Neurol Neurosur Ps 2017;88.
2016
Wan Y, et al. The refinement of luteinizing hormone (LH) output during pubertal maturation is associated with the recruitment of follicle in adult female mice. Clin Endocrinol 2016;84:2-3.
Tuong ZK, et al. Transgenic Adipose-specific Expression of the Nuclear Receptor RORalpha Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control. EBioMedicine 2016;11:101-117.
Tan HY, et al. Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone. J Physiol-London 2016;594:7309-7326.
Steyn FJ, et al. Neuroendocrine Regulation of Growth Hormone Secretion. Compr Physiol 2016;6:687-735.
Steyn F. Regulation of pulsatile growth hormone secretion: lessons from the mouse. Clin Endocrinol 2016;84:16-17.
Nabizadeh JA, et al. The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4(+) T Cell Responses. J Immunol 2016;196:4783-4792.
Nabizadeh J, et al. The complement C3a receptor contributes to melanoma tumourigenesis by regulating neutrophil and CD4(+) T cell responses. Eur J Immunol 2016;46:510-510.
Li R, et al. Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles. J Physiol-London 2016;594:7197-7213.
Ioannides ZA, et al. Altered Metabolic Homeostasis in Amyotrophic Lateral Sclerosis: Mechanisms of Energy Imbalance and Contribution to Disease Progression. Neurodegener Dis 2016;16:382-397.
Czieselsky K, et al. Pulse and Surge Profiles of Luteinizing Hormone Secretion in the Mouse. Endocrinology 2016;157:4794-4802.