Recycling to save the cell: retromer, endosomes & disease

Presented by Associate Professor Rohan Teasdale, School of Biomedical Sciences

Rohan Teasdale is currently a T&R academic within the School of Biomedical Sciences at the University of Queensland.  He gained his PhD at Monash University in 1995, worked as postdoctoral scientist at RW Johnson PRI, a Johnson and Johnson company in San Diego before joining IMB, UQ in 2000. Upon returning to Australia his focus has been on the characterisation of the mammalian endosomal system and the trafficking pathways originating from within this highly dynamic intracellular organelle. His Protein Trafficking in Disease research group has made key contributions including the discovery of the retromer protein complex that is a central regulator of early endosome protein trafficking and the PX/SNX family of proteins. Retromer has been recently implicated in neurodegeneration, including  Parkinson’s disease and we are investigating the molecular mechanisms underlying how its dysfunction causes Parkinson’s Disease.