Dr Anne Lagendijk
Affiliate Senior Research Fellow
School of Biomedical Sciences
Senior Research Fellow - GL
Institute for Molecular Bioscience
+61 7 334 62105
Book Chapter
Lagendijk, Anne Karine and Hogan, Benjamin M. (2015). VE-cadherin in Vascular Development: A Coordinator of Cell Signaling and Tissue Morphogenesis. Cellular Adhesion in Development and Disease. (pp. 325-352) edited by Alpha S. Yap. Maryland Heights, MO United States: Academic Press. doi: 10.1016/bs.ctdb.2014.11.024
Journal Articles
Essebier, Patricia, Keyser, Mikaela, Yordanov, Teodor, Hill, Brittany, Yu, Alexander, Noordstra, Ivar, Yap, Alpha S., Stehbens, Samantha J., Lagendijk, Anne K., Schimmel, Lilian and Gordon, Emma J. (2024). c-Src induced vascular malformations require localised matrix degradation at focal adhesions. Journal of Cell Science, 137 (13) jcs262101. doi: 10.1242/jcs.262101
Yordanov, Teodor E., Keyser, Mikaela S., Enriquez Martinez, Marco A., Esposito, Tyron, Tefft, Juliann B., Morris, Elysse K., Labzin, Larisa I., Stehbens, Samantha J., Rowan, Alan E., Hogan, Benjamin M., Chen, Christopher S., Lauko, Jan and Lagendijk, Anne K. (2024). Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels. APL Bioengineering, 8 (1) 016108, 016108. doi: 10.1063/5.0159330
Grimm, Lin, Mason, Elizabeth, Yu, Hujun, Dudczig, Stefanie, Panara, Virginia, Chen, Tyrone, Bower, Neil I., Paterson, Scott, Rondon Galeano, Maria, Kobayashi, Sakurako, Senabouth, Anne, Lagendijk, Anne K., Powell, Joseph, Smith, Kelly A., Okuda, Kazuhide S., Koltowska, Katarzyna and Hogan, Benjamin M. (2023). Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development. The EMBO Journal, 42 (11) e112590, e112590. doi: 10.15252/embj.2022112590
Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366
Morris, Elysse K., Daignault-Mill, Sheena, Stehbens, Samantha J., Genovesi, Laura A. and Lagendijk, Anne K. (2023). Addressing blood-brain-tumor-barrier heterogeneity in pediatric brain tumors with innovative preclinical models. Frontiers in Oncology, 13 1101522, 1-9. doi: 10.3389/fonc.2023.1101522
Chau, Tevin C. Y., Keyser, Mikaela S., Da Silva, Jason A., Morris, Elysse K., Yordanov, Teodor E., Duscyz, Kinga P., Paterson, Scott, Yap, Alpha S., Hogan, Benjamin M. and Lagendijk, Anne Karine (2022). Dynamically regulated focal adhesions coordinate endothelial cell remodelling in developing vasculature. Development, 149 (23) dev200454, 1-14. doi: 10.1242/dev.200454
Wu, Selwin K., Gomez, Guillermo A., Stehbens, Samantha, Acharya, Bipul R., Ratheesh, Aparna, Priya, Rashmi, Lagendijk, Anne and Bershadsky, Alexander (2022). Editorial: Forces in biology - Cell and developmental mechanobiology and its implications in disease - Volume II. Frontiers in Cell and Developmental Biology, 10 1082857, 1082857. doi: 10.3389/fcell.2022.1082857
Lagendijk, Anne and Chau, Tevin (2022). The people behind the papers – Tevin Chau and Anne Lagendijk. Boletin de Malariologia y Salud Ambiental, 149 (23) dev201441. doi: 10.1242/dev.201441
Gibson, Josie F., Bojarczuk, Aleksandra, Evans, Robert J., Kamuyango, Alfred Alinafe, Hotham, Richard, Lagendijk, Anne K., Hogan, Benjamin M., Ingham, Philip W., Renshaw, Stephen A. and Johnston, Simon A. (2022). Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection. PLoS pathogens, 18 (4) e1010389, e1010389. doi: 10.1371/journal.ppat.1010389
Koltowska, Katarzyna, Okuda, Kazuhide S., Gloger, Marleen, Rondon-Galeano, Maria, Mason, Elizabeth, Xuan, Jiachen, Dudczig, Stefanie, Chen, Huijun, Arnold, Hannah, Skoczylas, Renae, Bower, Neil I., Paterson, Scott, Lagendijk, Anne Karine, Baillie, Gregory J., Leshchiner, Ignaty, Simons, Cas, Smith, Kelly A., Goessling, Wolfram, Heath, Joan K., Pearson, Richard B., Sanij, Elaine, Schulte-Merker, Stefan and Hogan, Benjamin M. (2021). The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function. Nature Cell Biology, 23 (11), 1136-1147. doi: 10.1038/s41556-021-00784-w
Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350
Chau, Tevin CY., Baek, Sungmin, Coxam, Baptiste, Skoczylas, Renae, Rondon‐Galeano, Maria, Bower, Neil I., Wainwright, Elanor N., Stacker, Steven A., Cooper, Helen M., Koopman, Peter A., Lagendijk, Anne K., Harvey, Natasha L., François, Mathias and Hogan, Benjamin M. (2021). Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice. Developmental Dynamics, 251 (2) dvdy.390, 336-349. doi: 10.1002/dvdy.390
Duszyc, Kinga, Gomez, Guillermo A., Lagendijk, Anne K., Yau, Mei-Kwan, Nanavati, Bageshri Naimish, Gliddon, Briony L., Hall, Thomas E., Verma, Suzie, Hogan, Benjamin M., Pitson, Stuart M., Fairlie, David P., Parton, Robert G. and Yap, Alpha S. (2021). Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion. Current Biology, 31 (6), 1326-1336.e5. doi: 10.1016/j.cub.2021.01.003
Genovesi, Laura A., Puttick, Simon, Millar, Amanda, Kojic, Marija, Ji, Pengxiang, Lagendijk, Anne K., Brighi, Caterina, Bonder, Claudine S, Adolphe, Christelle and Wainwright, Brandon J. (2020). Patient derived orthotopic xenograft models of Medulloblastoma lack a functional blood brain barrier. Neuro-Oncology, 23 (5), 732-742. doi: 10.1093/neuonc/noaa266
Teo, Jessica L, Tomatis, Vanesa M, Coburn, Luke, Lagendijk, Anne K, Schouwenaar, Irin-Maya, Budnar, Srikanth, Hall, Thomas E, Verma, Suzie, McLachlan, Robert W, Hogan, Benjamin M, Parton, Robert G, Yap, Alpha S and Gomez, Guillermo A (2020). Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion. Molecular Biology of the Cell, 31 (23), 2495-2629. doi: 10.1091/mbc.E20-01-0084
Chaudhury, Smrita, Okuda, Kazuhide S., Koltowska, Katarzyna, Lagendijk, Anne K., Paterson, Scott, Baillie, Gregory J., Simons, Cas, Smith, Kelly A., Hogan, Benjamin M. and Bower, Neil I. (2020). Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo. Development, 147 (18) dev190983, dev.190983. doi: 10.1242/dev.190983
Baek, Sungmin, Oh, Tae Gyu, Secker, Genevieve, Sutton, Drew L., Okuda, Kazuhide S., Paterson, Scott, Bower, Neil I., Toubia, John, Koltowska, Katarzyna, Capon, Samuel J., Baillie, Gregory J., Simons, Cas, Muscat, George E.O., Lagendijk, Anne K., Smith, Kelly A., Harvey, Natasha L. and Hogan, Benjamin M. (2019). The alternative splicing regulator Nova2 constrains vascular Erk signaling to limit specification of the lymphatic lineage. Developmental Cell, 49 (2), 279-292. doi: 10.1016/j.devcel.2019.03.017
Ando, Koji, Wang, Weili, Peng, Di, Chiba, Ayano, Lagendijk, Anne K., Barske, Lindsey, Crump, J. Gage, Stainier, Didier Y. R., Lendahl, Urban, Koltowska, Katarzyna, Hogan, Benjamin M., Fukuhara, Shigetomo, Mochizuki, Naoki and Betsholtz, Christer (2019). Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling. Development, 146 (2) dev165589, dev165589. doi: 10.1242/dev.165589
Paatero, Ilkka, Sauteur, Loïc, Lee, Minkyoung, Lagendijk, Anne K., Heutschi, Daniel, Wiesner, Cora, Guzmán, Camilo, Bieli, Dimitri, Hogan, Benjamin M., Affolter, Markus and Belting, Heinz-Georg (2018). Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction. Nature Communications, 9 (1) 3545, 3545. doi: 10.1038/s41467-018-05851-9
Grassini, Daniela R., Lagendijk, Anne K., De Angelis, Jessica E., Da Silva, Jason, Jeanes, Angela, Zettler, Nicole, Bower, Neil I., Hogan, Benjamin M. and Smith, Kelly A. (2018). Nppa and Nppb act redundantly during zebrafish cardiac development to confine AVC marker expression and reduce cardiac jelly volume. Development, 145 (12) dev160739, dev160739. doi: 10.1242/dev.160739
Lagendijk, Anne K., Yap, Alpha S. and Hogan, Benjamin M. (2018). Notching a new pathway in vascular flow sensing. Trends in Cell Biology, 28 (3), 173-175. doi: 10.1016/j.tcb.2017.12.003
Lagendijk, Anne Karine, Gomez, Guillermo A, Baek, Sungmin, Hesselson, Daniel, Hughes, William E, Paterson, Scott, Conway, Daniel E, Belting, Heinz-Georg, Affolter, Markus, Smith, Kelly A, Schwartz, Martin A, Yap, Alpha S and Hogan, Benjamin M (2017). Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish. Nature communications, 8 (1) 1402, 1-12. doi: 10.1038/s41467-017-01325-6
Chiang, Ivy Kim-Ni, Fritzsche, Martin, Pichol-Thievend, Cathy, Neal, Alice, Holmes, Kelly, Lagendijk, Anne, Overman, Jeroen, D'Angelo, Donatella, Omini, Alice, Hermkens, Dorien, Lesieur, Emmanuelle, Fossat, Nicolas, Radziewic, Tania, Liu, Ke, Ratnayaka, Indrika, Corada, Monica, Bou-Gharios, George, Tam, Patrick P. L., Carroll, Jason, Dejana, Elisabetta, Schulte-Merker, Stefan, Hogan, Benjamin M., Beltrame, Monica, De Val, Sarah and Francois, Mathias (2017). Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development (vol 144, pg 2629, 2017). Development, 144 (20), 3847-3848. doi: 10.1242/dev.159715
Chiang, Ivy Kim-Ni, Fritzsche, Martin, Pichol-Thievend, Cathy, Neal, Alice, Holmes, Kelly, Lagendijk, Anne, Overman, Jeroen, D'Angelo, Donatella, Omini, Alice, Hermkens, Dorien, Lesieur, Emmanuelle, Liu, Ke, Ratnayaka, Indrika, Corada, Monica, Bou-Gharios, George, Carroll, Jason, Dejana, Elisabetta, Schulte-Merker, Stefan, Hogan, Benjamin, Beltrame, Monica, De Val, Sarah and Francois, Mathias (2017). SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, 144 (14), 2629-2639. doi: 10.1242/dev.146241
Bower, Neil I., Koltowska, Katarzyna, Pichol-Thievend, Cathy, Virshup, Isaac, Paterson, Scott, Lagendijk, Anne K., Wang, Weili, Lindsey, Benjamin W., Bent, Stephen J., Baek, Sungmin, Rondon-Galeano, Maria, Hurley, Daniel G., Mochizuki, Naoki, Simons, Cas, Francois, Mathias, Wells, Christine A., Kaslin, Jan and Hogan, Benjamin M. (2017). Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish. Nature Neuroscience, 20 (6), 774-783. doi: 10.1038/nn.4558
De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136). Developmental Cell, 40 (4), 421-421. doi: 10.1016/j.devcel.2017.02.005
De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover. Developmental Cell, 40 (2), 123-136. doi: 10.1016/j.devcel.2016.12.017
San, Bilge, Chrispijn, Naomi D., Wittkopp, Nadine, Van Heeringen, Simon J., Lagendijk, Anne K., Aben, Marco, Bakkers, Jeroen, Ketting, Rene F. and Kamminga, Leonie M. (2016). Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2. Scientific Reports, 6 (1) 24658. doi: 10.1038/srep24658
Koltowska, Katarzyna, Paterson, Scott, Bower, Neil I., Baillie, Gregory J., Lagendijk, Anne K., Astin, Jonathan W., Chen, Huijun, Francois, Mathias, Crosier, Philip S., Taft, Ryan J., Simons, Cas, Smith, Kelly A. and Hogan, Benjamin M. (2015). mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes and Development, 29 (15), 1618-1630. doi: 10.1101/gad.263210.115
Koltowska, Katarzyna, Lagendijk, Anne K., Pichol-Thievend, Cathy, Fischer, Johanna C., Francois, Mathias, Ober, Elke A., Yap, Alpha S. and Hogan, Benjamin M. (2015). Vegfc regulates bipotential precursor division and prox1 expression to promote lymphatic identity in zebrafish. Cell Reports, 13 (9), 1828-1841. doi: 10.1016/j.celrep.2015.10.055
Wu, Selwin K., Lagendijk, Anne K., Hogan, Benjamin M., Gomez, Guillermo A. and Yap, Alpha S. (2015). Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer. Cell Cycle, 14 (3), 315-322. doi: 10.4161/15384101.2014.989127
Lagendijk, Anne Karine, Yap, Alpha S. and Hogan, Benjamin M. (2014). Endothelial cell-cell adhesion during zebrafish vascular development. Cell Adhesion and Migration, 8 (2), 136-145. doi: 10.4161/cam.28229
Goudarzi, Mehdi, Strate, Ina, Paksa, Azadeh, Lagendijk, Anne-Karine, Bakkers, Jeroen and Raz, Erez (2013). On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling. Nature Genetics, 45 (11), 1264-1265. doi: 10.1038/ng.2793
Lagendijk, Anne Karine, Szabó, András, Merks, Roeland M. H. and Bakkers, Jeroen (2013). Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation. Trends in Cardiovascular Medicine, 23 (5), 135-142. doi: 10.1016/j.tcm.2012.10.002
Noel, Emily S., Verhoeven, Manon, Lagendijk, Anne Karine, Tessadori, Federico, Smith, Kelly, Choorapoikayil, Suma, Den Hertog, Jeroen and Bakkers, Jeroen (2013). A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nature Communications, 4 (1) 2754. doi: 10.1038/ncomms3754
Lagendijk, A. K., Moulton, J. D. and Bakkers, J. (2012). Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues. Biology Open, 1 (6), 566-569. doi: 10.1242/bio.2012810
de Pater, Emma, Ciampricotti, Metamia, Priller, Florian, Veerkamp, Justus, Strate, Ina, Smith, Kelly, Lagendijk, Anne Karine, Schilling, Thomas F., Herzog, Wiebke, Abdelilah-Seyfried, Salim, Hammerschmidt, Matthias and Bakkers, Jeroen (2012). Bmp signaling exerts opposite effects on cardiac differentiation. Circulation Research, 110 (4), 578-587. doi: 10.1161/CIRCRESAHA.111.261172
Smith, Kelly A., Lagendijk, Anne K., Courtney, Andrew D., Chen, Huijun, Paterson, Scott, Hogan, Benjamin M., Wicking, Carol and Bakkers, Jeroen (2011). Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development, 138 (19), 4193-4198. doi: 10.1242/dev.065375
Lagendijk, Anne Karine, Goumans, Marie Jose, Burkhard, Silja Barbara and Bakkers, Jeroen (2011). MicroRNA-23 restricts cardiac valve formation by inhibiting has2 and extracellular hyaluronic acid production. Circulation Research, 109 (6), 649-657. doi: 10.1161/CIRCRESAHA.111.247635
Ghani, Saeed, Riemke, Pia, Schönheit, Jörg, Lenze, Dido, Stumm, Jürgen, Hoogenkamp, Maarten, Lagendijk, Anne, Heinz, Sven, Bonifer, Constanze, Bakkers, Jeroen, Abdelilah-Seyfried, Salim, Hummel, Michael and Rosenbauer, Frank (2011). Macrophage development from HSCs requires PU.1-coordinated microRNA expression. Blood, 118 (8), 2275-2284. doi: 10.1182/blood-2011-02-335141
Lagendijk, Anne Karine, Smith, Kelly A. and Bakkers, Jeroen (2010). Genetics of congenital heart defects: A candidate gene approach. Trends in Cardiovascular Medicine, 20 (4), 124-128. doi: 10.1016/j.tcm.2010.10.003
Marques, Ines J., Weiss, Frank U., Vlecken, Danielle H., Nitsche, Claudia, Bakkers, Jeroen, Lagendijk, Anne K., Partecke, Lars I., Heidecke, Claus-Dieter, Lerch, Markus M. and Bagowski, Christoph P. (2009). Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model. BMC Cancer, 9 (Article# 128) 128, 1-13. doi: 10.1186/1471-2407-9-128
Kamsteeg, Erik-Jan, Savelkoul, Paul J. M., Hendriks, Giel, Konings, Irene B. M., Nivillac, Nicole M. I., Lagendijk, Anne Karine., van der Sluijs, Peter and Deen, Peter M. T. (2008). Missorting of the Aquaporin-2 mutant E258K to multivesicular bodies/lysosomes in dominant NDI is associated with its monoubiquitination and increased phosphorylation by PKC but is due to the loss of E258. Pflugers Archiv European Journal of Physiology, 455 (6), 1041-1054. doi: 10.1007/s00424-007-0364-6
Kloosterman, Wigard P., Lagendijk, Anne K., Ketting, Rene F., Moulton, Jon D. and Plasterk, Ronal H. A. (2007). Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biology, 5 (8), 1738-1749. doi: 10.1371/journal.pbio.0050203
van Beest, Moniek, Robben, Joris H., Savelkoul, Paul J. M., Hendriks, Giel, Devonald, Mark A. J., Konings, Irene B. M., Lagendijk, Anne K., Karet, Fiona and Deen, Peter M. T. (2006). Polarisation, key to good localisation. BBA: Biomembranes, 1758 (8), 1126-1133. doi: 10.1016/j.bbamem.2006.03.007
Conference Papers
Morris, Elysse, Daignault-Mill, Sheena, Ju, Robert J., da Silva, Jason, Gordon, Emma, Wainwright, Brandon, Stehbens, Samantha, Genovesi, Laura and Lagendijk, Anne (2023). Uncovering Dynamic Changes In Medulloblastoma Associated Vasculature In Zebrafish. 2023 Pediatric Neuro-Oncology Research Conference, Washington, DC United States, 22-24 June 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/neuonc/noad073.274
Koltowska, Kaska, Paterson, Scott, Lagendijk, Anne Karine, Chen, Huijun, Baillie, Gregory, Leshchiner, Ignat, Geossling, Wolfram, Smith, Kelly, Simons, Cas, Schulte-Merker, Stefan and Hogan, Ben (2017). Lymphatic and facial defects 1 regulates expansion of the lymphatic endothelial cell lineage upon its emergence from the cardinal vein. 18th International Congress of Developmental Biology, Singapore, Singapore, 18 - 22 June 2017. Shannon, Clare Ireland: Elsevier. doi: 10.1016/j.mod.2017.04.447
Smith, K., Paterson, S., Capon, S., De Angelis, J., Grassini, D., Lagendijk, A., Bailey, G., Simons, C., Taft, R. and Hogan, B. (2014). A large-scale phenotype-to-genotype screen identifies regulators of cardiac development and function. International Clinical Cardiovascular Genetics Conference, Brisbane, Australia, 6-9 August 2014. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2014.07.045