Dr Kaska Koltowska

Doroszko, Milena, Stockgard, Rebecka, Uppman, Irem, Heinold, Josephine, Voukelatou, Faidra, Mangukiya, Hitesh Bhagavanbhai, Millner, Thomas O., Skeppas, Madeleine, Ballester Bravo, Mar, Elgendy, Ramy, Berglund, Maria, Elfineh, Ludmila, Krona, Cecilia, Kundu, Soumi, Koltowska, Katarzyna, Marino, Silvia, Larsson, Ida and Nelander, Sven (2025). The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states. Nature Communications, 16 (1) 6662. doi: 10.1038/s41467-025-61999-1

Arnold, Hannah, Panara, Virginia, Allalou, Amin and Koltowska, Katarzyna (2025). Protocol to computationally average confocal images of zebrafish lymphatic vessels to identify phenotypes. STAR Protocols, 6 (1) 103632, 103632-1. doi: 10.1016/j.xpro.2025.103632

Panara, Virginia, Varaliová, Zuzana, Wilting, Jörg, Koltowska, Katarzyna and Jeltsch, Michael (2024). The relationship between the secondary vascular system and the lymphatic vascular system in fish. Biological Reviews, 99 (6), 2108-2133. doi: 10.1111/brv.13114

Nguyen, Le Phuong, Song, Wenxin, Yang, Ye, Tran, Anh P., Weston, Thomas A., Jung, Hyesoo, Tu, Yiping, Kim, Paul H., Kim, Joonyoung R., Xie, Katherine, Yu, Rachel G., Scheithauer, Julia, Presnell, Ashley M., Ploug, Michael, Birrane, Gabriel, Arnold, Hannah, Koltowska, Katarzyna, Mäe, Maarja A., Betsholtz, Christer, He, Liqun, Goodwin, Jeffrey L., Beigneux, Anne P., Fong, Loren G. and Young, Stephen G. (2024). Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species. JCI Insight, 9 (20) e184940. doi: 10.1172/jci.insight.184940

Panara, Virginia, Yu, Hujun, Peng, Di, Staxäng, Karin, Hodik, Monika, Filipek-Gorniok, Beata, Kazenwadel, Jan, Skoczylas, Renae, Mason, Elizabeth, Allalou, Amin, Harvey, Natasha L., Haitina, Tatjana, Hogan, Benjamin M. and Koltowska, Katarzyna (2024). Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds. Development, 151 (9) dev202525, 1-14. doi: 10.1242/dev.202525

Koltowska, Kaska, Jakus, Zoltán, Hong, Young-Kwon and Kume, Tsutomu (2023). Editorial: Lymphatic system: organ specific functions in health and disease. Frontiers in cell and developmental biology, 11 1224584, 1224584-11. doi: 10.3389/fcell.2023.1224584

Grimm, Lin, Mason, Elizabeth, Yu, Hujun, Dudczig, Stefanie, Panara, Virginia, Chen, Tyrone, Bower, Neil I., Paterson, Scott, Rondon Galeano, Maria, Kobayashi, Sakurako, Senabouth, Anne, Lagendijk, Anne K., Powell, Joseph, Smith, Kelly A., Okuda, Kazuhide S., Koltowska, Katarzyna and Hogan, Benjamin M. (2023). Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development. The EMBO Journal, 42 (11) e112590, e112590. doi: 10.15252/embj.2022112590

Kazenwadel, Jan, Venugopal, Parvathy, Oszmiana, Anna, Toubia, John, Arriola-Martinez, Luis, Panara, Virginia, Piltz, Sandra G., Brown, Chris, Ma, Wanshu, Schreiber, Andreas W., Koltowska, Katarzyna, Taoudi, Samir, Thomas, Paul Q., Scott, Hamish S. and Harvey, Natasha L. (2023). A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature. Nature, 614 (7947), 343-348. doi: 10.1038/s41586-022-05650-9

Richards, Mark, Nwadozi, Emmanuel, Pal, Sagnik, Martinsson, Pernilla, Kaakinen, Mika, Gloger, Marleen, Sjöberg, Elin, Koltowska, Katarzyna, Betsholtz, Christer, Eklund, Lauri, Nordling, Sofia and Claesson-Welsh, Lena (2022). Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner. eLife, 11 e78517, 1-28. doi: 10.7554/eLife.78517

Arnold, Hannah, Panara, Virginia, Hußmann, Melina, Filipek-Gorniok, Beata, Skoczylas, Renae, Ranefall, Petter, Gloger, Marleen, Allalou, Amin, Hogan, Benjamin M., Schulte-Merker, Stefan and Koltowska, Katarzyna (2022). mafba and mafbb differentially regulate lymphatic endothelial cell migration in topographically distinct manners. Cell Reports, 39 (12) 110982, 1-19. doi: 10.1016/j.celrep.2022.110982

Panara, Virginia, Monteiro, Rui and Koltowska, Katarzyna (2022). Epigenetic Regulation of Endothelial Cell Lineages During Zebrafish Development-New Insights From Technical Advances. Frontiers in Cell and Developmental Biology, 10, 1-17. doi: 10.3389/fcell.2022.891538

Almstedt, Elin, Rosén, Emil, Gloger, Marleen, Stockgard, Rebecka, Hekmati, Neda, Koltowska, Katarzyna, Krona, Cecilia and Nelander, Sven (2022). Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts. Neuro-oncology, 24 (5) noab264, 726-738. doi: 10.1093/neuonc/noab264

Peng, Di, Ando, Koji, Hußmann, Melina, Gloger, Marleen, Skoczylas, Renae, Mochizuki, Naoki, Betsholtz, Christer, Fukuhara, Shigetomo, Schulte-Merker, Stefan, Lawson, Nathan D. and Koltowska, Katarzyna (2022). Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells. eLife, 11 e74094, 1-23. doi: 10.7554/eLife.74094

Koltowska, Katarzyna, Okuda, Kazuhide S., Gloger, Marleen, Rondon-Galeano, Maria, Mason, Elizabeth, Xuan, Jiachen, Dudczig, Stefanie, Chen, Huijun, Arnold, Hannah, Skoczylas, Renae, Bower, Neil I., Paterson, Scott, Lagendijk, Anne Karine, Baillie, Gregory J., Leshchiner, Ignaty, Simons, Cas, Smith, Kelly A., Goessling, Wolfram, Heath, Joan K., Pearson, Richard B., Sanij, Elaine, Schulte-Merker, Stefan and Hogan, Benjamin M. (2021). The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function. Nature Cell Biology, 23 (11), 1136-1147. doi: 10.1038/s41556-021-00784-w

Stritt, Simon, Koltowska, Katarzyna and Mäkinen, Taija (2021). Homeostatic maintenance of the lymphatic vasculature. Trends in Molecular Medicine, 27 (10), 955-970. doi: 10.1016/j.molmed.2021.07.003

Okuda, Kazuhide S., Ng, Mei Fong, Ruslan, Nur Faizah, Bower, Neil I., Song, Dedrick Soon Seng, Chen, Huijun, Baek, Sungmin, Crosier, Philip S., Koltowska, Katarzyna, Astin, Jonathan W., Tan, Pei Jean, Hogan, Benjamin M. and Patel, Vyomesh (2021). 3,4-Difluorobenzocurcumin inhibits VGFC-VGFR3-ERK signalling to block developmental lymphangiogenesis in zebrafish. Pharmaceuticals, 14 (7) 614, 1-17. doi: 10.3390/ph14070614

de Oliveira, Marta Bastos, Meier, Katja, Jung, Simone, Bartels-Klein, Eireen, Coxam, Baptiste, Geudens, Ilse, Szymborska, Anna, Skoczylas, Renae, Fechner, Ines, Koltowska, Katarzyna and Gerhardt, Holger (2021). Vasohibin 1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. Development (Cambridge, England), 148 (4) dev194993, 1-14. doi: 10.1242/dev.194993

Chaudhury, Smrita, Okuda, Kazuhide S., Koltowska, Katarzyna, Lagendijk, Anne K., Paterson, Scott, Baillie, Gregory J., Simons, Cas, Smith, Kelly A., Hogan, Benjamin M. and Bower, Neil I. (2020). Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo. Development, 147 (18) dev190983, dev.190983. doi: 10.1242/dev.190983

Rondon‐Galeano, Maria, Skoczylas, Renae, Bower, Neil I., Simons, Cas, Gordon, Emma, Francois, Mathias, Koltowska, Katarzyna and Hogan, Benjamin M. (2020). MAFB modulates the maturation of lymphatic vascular networks in mice. Developmental Dynamics, 249 (10) dvdy.209, 1201-1216. doi: 10.1002/dvdy.209

Koltowska, Katarzyna (2019). A zebrafish genetic model enables an invaluable discovery: a lifesaving treatment for a lymphatic anomaly. Lab Animal, 48 (10), 305-306. doi: 10.1038/s41684-019-0401-z

Grimm, Lin, Nakajima, Hiroyuki, Chaudhury, Smrita, Bower, Neil I., Okuda, Kazuhide S., Cox, Andrew G., Harvey, Natasha L., Koltowska, Katarzyna, Mochizuki, Naoki and Hogan, Benjamin M. (2019). Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk. eLife, 8 e42881. doi: 10.7554/elife.42881

Baek, Sungmin, Oh, Tae Gyu, Secker, Genevieve, Sutton, Drew L., Okuda, Kazuhide S., Paterson, Scott, Bower, Neil I., Toubia, John, Koltowska, Katarzyna, Capon, Samuel J., Baillie, Gregory J., Simons, Cas, Muscat, George E.O., Lagendijk, Anne K., Smith, Kelly A., Harvey, Natasha L. and Hogan, Benjamin M. (2019). The alternative splicing regulator Nova2 constrains vascular Erk signaling to limit specification of the lymphatic lineage. Developmental Cell, 49 (2), 279-292. doi: 10.1016/j.devcel.2019.03.017

Ando, Koji, Wang, Weili, Peng, Di, Chiba, Ayano, Lagendijk, Anne K., Barske, Lindsey, Crump, J. Gage, Stainier, Didier Y. R., Lendahl, Urban, Koltowska, Katarzyna, Hogan, Benjamin M., Fukuhara, Shigetomo, Mochizuki, Naoki and Betsholtz, Christer (2019). Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling. Development, 146 (2) dev165589, dev165589. doi: 10.1242/dev.165589

Bower, Neil I., Koltowska, Katarzyna, Pichol-Thievend, Cathy, Virshup, Isaac, Paterson, Scott, Lagendijk, Anne K., Wang, Weili, Lindsey, Benjamin W., Bent, Stephen J., Baek, Sungmin, Rondon-Galeano, Maria, Hurley, Daniel G., Mochizuki, Naoki, Simons, Cas, Francois, Mathias, Wells, Christine A., Kaslin, Jan and Hogan, Benjamin M. (2017). Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish. Nature Neuroscience, 20 (6), 774-783. doi: 10.1038/nn.4558

Koltowska, Katarzyna, Paterson, Scott, Bower, Neil I., Baillie, Gregory J., Lagendijk, Anne K., Astin, Jonathan W., Chen, Huijun, Francois, Mathias, Crosier, Philip S., Taft, Ryan J., Simons, Cas, Smith, Kelly A. and Hogan, Benjamin M. (2015). mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes and Development, 29 (15), 1618-1630. doi: 10.1101/gad.263210.115

Koltowska, Katarzyna, Lagendijk, Anne K., Pichol-Thievend, Cathy, Fischer, Johanna C., Francois, Mathias, Ober, Elke A., Yap, Alpha S. and Hogan, Benjamin M. (2015). Vegfc regulates bipotential precursor division and prox1 expression to promote lymphatic identity in zebrafish. Cell Reports, 13 (9), 1828-1841. doi: 10.1016/j.celrep.2015.10.055

Le Guen, Ludovic, Karpanen, Terhi, Dorte, Schulte, Harris, Nicole C., Koltowska, Katarzyna, Roukens, Guy, Bower, Neil I., van Impel, Andreas, Stacker, Steven A., Achen, Marc G., Schulte-Merker, Stefan and Hogan, Benjamin M. (2014). Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development, 141 (6), 1239-1249. doi: 10.1242/dev.100495

Duong, Tam, Koltowska, Katarzyna, Pichol-Thievend, Cathy, Le Guen, Ludovic, Fontaine, Frank R., Smith, Kelly, Truong, Vy, Skoczylas, Renae, Stacker, Steven A., Achen, Marc G., Koopman, Peter, Hogan, Ben and Francois, Mathias (2013). VEGFD regulates blood vascular development by modulating SOX18 activity. Blood, 123 (7), 1102-1112. doi: 10.1182/blood-2013-04-495432

Kartopawiro, Joëlle, Neil Bower, Neil I., Karnezis, Tara, Kazenwadel, Jan, Betterman, Kelly L., Lesieur, Emmanuelle, Koltowska, Katarzyna, Astin, Jonathan, Crosier, Philip, Vermeren, Sonja, Achen, Marc G., Stacker, Steven A., Smith, Kelly A., Harvey, Natasha L., François, Mathias and Hogan, Benjamin M. (2013). Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human Molecular Genetics, Advance Access (5) ddt518, 1-12. doi: 10.1093/hmg/ddt518

Koltowska, Katarzyna, Apitz, Holger, Stamataki, Despina, Hirst, Elizabeth M. A., Verkade, Heather, Salecker, Iris and Ober, Elke A. (2013). Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis. Development (Cambridge), 140 (9), 1912-1918. doi: 10.1242/dev.093583

Koltowska, Katarzyna, Betterman, Kelly L., Harvey, Natasha L. and Hogan, Benjamin M. (2013). Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature. Development, 140 (9), 1857-1870. doi: 10.1242/dev.089565

Wood, Andrew J., Schulz, Reiner, Woodfine, Kathryn, Koltowska, Katarzyna, Beechey, Colin V., Peters, Jo, Bourc'his, Deborah and Oakey, Rebecca J. (2008). Regulation of alternative polyadenylation by genomic imprinting. Genes and Development, 22 (9), 1141-1146. doi: 10.1101/gad.473408

Koltowska, Kaska, Paterson, Scott, Lagendijk, Anne Karine, Chen, Huijun, Baillie, Gregory, Leshchiner, Ignat, Geossling, Wolfram, Smith, Kelly, Simons, Cas, Schulte-Merker, Stefan and Hogan, Ben (2017). Lymphatic and facial defects 1 regulates expansion of the lymphatic endothelial cell lineage upon its emergence from the cardinal vein. 18th International Congress of Developmental Biology, Singapore, Singapore, 18 - 22 June 2017. Shannon, Clare Ireland: Elsevier. doi: 10.1016/j.mod.2017.04.447

Le Guen, Ludovic, Karpanen, Terhi, Schulte, Dorte, Harris, Nicole C., Bower, Neil, I., Koltowska, Katarzyna, Roukens, Guy, Van Impel, Andreas, Stacker, Steven A., Achen, Marc, Schulte-Merker, Stefan and Hogan, Ben M. (2014). Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Vascular matrix biology and bioengineering workshop IV and biology of signaling in the cardiovascular system workshop III, Hyannis, MA United States, 20 - 24 October 1013. Dordrecht, The Netherlands: Springer Netherlands. doi: 10.1007/s10456-013-9412-3

Koltowska, Katarzyna and Ober, Elke A. (2009). The clamped s819 gene promotes liver differentiation and growth. 16th Annual Conference of the International-Society-of-Development-Biologists, Edinburgh Scotland, Sep 06-10, 2009. ELSEVIER SCIENCE BV. doi: 10.1016/j.mod.2009.06.399

Dr Kaska Koltowska

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