Associate Professor Johan Rosengren
Associate Professor
School of Biomedical Sciences
+61 7 336 51403
Dr Johan Rosengren heads the peptide structural biology lab.
Researcher biography
Dr Rosengren is an Associate Professor at the School of Biomedical Sciences, University of Queensland. He completed his PhD, which focused on structure-activity relationships of antimicrobial peptides, under the supervision of Professor David Craik at the Institute for Molecular Bioscience, UQ, in 2003. After two years of post-doctoral work at IMB he moved to Sweden in 2005 to take up a position as Assistant Professor at Linnaeus University, Kalmar. During 2008-2009 he held a joint appointment between Linnaeus University and Uppsala University. In 2009 he was awarded the Swedish "Docent" title before returning to University of Queensland as a Senior Research Officer, funded by an NHMRC Career Development Award and an ARC Future Fellowship. Dr Rosengren's research focuses on structure activity relationships of bioactive peptides, in particular peptide hormones and the use of NMR spectroscopy in the design of novel peptide drug leads.
PhD and MPhil Supervision
- View current and completed supervisions on UQ Researchers.
Find out more information on how to apply for a Research Higher Degree (MPhil or PhD) with the School. For all enquiries regarding research supervision, please contact ask@uq.edu.au.
Book Chapters
Schroeder, Christina I. and Rosengren, K. Johan (2020). Three-dimensional structure determination of peptides using solution nuclear magnetic resonance spectroscopy. Snake and spider toxins: methods and protocols. (pp. 129-162) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-9845-6_7
Daly, Norelle L. and Rosengren, K. Johan (2015). Structural studies of cyclotides. Plant cyclotides. (pp. 155-186) edited by David Craik. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.abr.2015.09.003
Rosengren, K. Johan, Daly, N. L. and Craik, D. J. (2009). NMR of peptide toxins. Annual reports on NMR Spectroscopy. (pp. 89-147) edited by Graham A. Webb. Oxford England U.K.: Academic Press Elsevier. doi: 10.1016/S0066-4103(09)06802-1
Journal Articles
Budusan, Elena, Payne, Colton D., Gonzalez, Tye I., Obergrussberger, Alison, Becker, Nadine, Clark, Richard J., Rosengren, K. Johan, Rash, Lachlan D. and Cristofori-Armstrong, Ben (2024). The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation. Biochemical Pharmacology, 228 116175, 1-12. doi: 10.1016/j.bcp.2024.116175
Wang, Dan, Herzig, Volker, Dekan, Zoltan, Rosengren, K. Johan, Payne, Colton D., Hasan, Md. Mahadhi, Zhuang, Jiajie, Bourinet, Emmanuel, Ragnarsson, Lotten, Alewood, Paul F. and Lewis, Richard J. (2024). Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical pain. International Journal of Molecular Sciences, 25 (9) 4745. doi: 10.3390/ijms25094745
Smallwood, Taylor B., Krumpe, Lauren R. H., Payne, Colton D., Klein, Victoria G., O'Keefe, Barry R., Clark, Richard J., Schroeder, Christina I. and Rosengren, K. Johan (2024). Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues. Chemical Science, 15 (33), 13227-13233. doi: 10.1039/d4sc01976h
Baumann, Christian, Chiang, Wan‐Chin, Valsecchi, Renato, Jurt, Simon, Deluigi, Mattia, Schuster, Matthias, Rosengren, Karl Johan, Plückthun, Andreas and Zerbe, Oliver (2023). Side‐chain dynamics of the α1B‐adrenergic receptor determined by NMR via methyl relaxation. Protein Science, 32 (11) e4801, 1-18. doi: 10.1002/pro.4801
Bathgate, Ross A. D., Praveen, Praveen, Sethi, Ashish, Furuya, Werner I., Dhingra, Rishi R., Kocan, Martina, Ou, Qinghao, Valkovic, Adam L., Gil-Miravet, Isis, Navarro-Sánchez, Mónica, Olucha-Bordonau, Francisco E., Gundlach, Andrew L., Rosengren, K. Johan, Gooley, Paul R., Dutschmann, Mathias and Hossain, Mohammed Akhter (2023). Noncovalent peptide stapling using alpha-methyl-l-phenylalanine for α-helical peptidomimetics. Journal of the American Chemical Society, 145 (37), 20242-20247. doi: 10.1021/jacs.3c02743
Adams, Zoë C., Silvestri, Anthony P., Chiorean, Sorina, Flood, Dillon T., Balo, Brian P., Shi, Yifan, Holcomb, Matthew, Walsh, Shawn I., Maillie, Colleen A., Pierens, Gregory K., Forli, Stefano, Rosengren, K. Johan and Dawson, Philip E. (2023). Stretching peptides to generate small molecule β-strand mimics. ACS Central Science, 9 (4), 648-656. doi: 10.1021/acscentsci.2c01462
Kuschert, Sarah, Stroet, Martin, Chin, Yanni Ka-Yan, Conibear, Anne Claire, Jia, Xinying, Lee, Thomas, Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, Peter, Rosengren, Karl Johan, Mark, Alan Edward and Mobli, Mehdi (2023). Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR. Magnetic Resonance, 4 (1), 57-72. doi: 10.5194/mr-4-57-2023
Goncalves Monteiro, Daniela Goncalves, Rishi, Gautam, Gorman, Declan M., Burnet, Guillaume, Aliyanto, Randy, Rosengren, K. Johan, Frazer, David M., Subramaniam, V. Nathan and Clark, Richard J. (2022). Engineering peptide inhibitors of the HFE–transferrin receptor 1 complex. Molecules, 27 (19) 6581, 1-13. doi: 10.3390/molecules27196581
Prasad, Anup K., Tiwari, Chandni, Ray, Sourav, Holden, Stephanie, Armstrong, David A., Rosengren, K. Johan, Rodger, Alison, Panwar, Ajay S. and Martin, Lisandra L. (2022). Secondary structure transitions for a family of amyloidogenic, antimicrobial uperin 3 peptides in contact with sodium dodecyl sulfate. ChemPlusChem, 87 (1) e202100408, e202100408. doi: 10.1002/cplu.202100408
Steffen, Karin, Laborde, Quentin, Gunasekera, Sunithi, Payne, Colton D., Rosengren, K. Johan, Riesgo, Ana, Göransson, Ulf and Cárdenas, Paco (2021). Barrettides: a peptide family specifically produced by the deep-sea sponge Geodia barretti. Journal of Natural Products, 84 (12) acs.jnatprod.1c00938, 3138-3146. doi: 10.1021/acs.jnatprod.1c00938
Survery, Sabeen, Hurtig, Fredrik, Haq, Syed Razaul, Eriksson, Jens, Guy, Lionel, Rosengren, K. Johan, Lindås, Ann-Christin and Chi, Celestine N. (2021). Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding. Communications Biology, 4 (1) 1024, 1-14. doi: 10.1038/s42003-021-02543-x
Payne, Colton D., Vadlamani, Grishma, Hajiaghaalipour, Fatemeh, Muhammad, Taj, Fisher, Mark F., Andersson, Håkan S., Göransson, Ulf, Clark, Richard J., Bond, Charles S., Mylne, Joshua S. and Rosengren, K. Johan (2021). Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides. RSC Chemical Biology, 2 (6), 1682-1691. doi: 10.1039/d1cb00155h
Clark, Richard J., Phan, Thanh Huyen, Song, Angela, Ouellette, André J., Conibear, Anne C. and Rosengren, K. Johan (2021). A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4. Peptide Science, 114 (1) e24250. doi: 10.1002/pep2.24250
Gorman, Declan M., Li, Xaria X., Payne, Colton D., Cui, Cedric S., Lee, John D., Rosengren, K. Johan, Woodruff, Trent M. and Clark, Richard J. (2021). Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivo. ACS Pharmacology and Translational Science, 4 (6) acsptsci.1c00199, 1808-1817. doi: 10.1021/acsptsci.1c00199
Payne, Colton D., Fisher, Mark F., Mylne, Joshua S. and Rosengren, K. Johan (2021). Structural characterization of the PawL-derived peptide family, an ancient subfamily of orbitides. Journal of Natural Products, 84 (11) acs.jnatprod.1c00672, 2914-2922. doi: 10.1021/acs.jnatprod.1c00672
Smallwood, Taylor B., Navarro, Severine, Cristofori-Armstrong, Ben, Watkins, Thomas S., Tungatt, Katie, Ryan, Rachael Y.M., Haigh, Oscar L., Lutzky, Viviana P., Mulvenna, Jason P., Rosengren, K. Johan, Loukas, Alex, Miles, John J. and Clark, Richard J. (2021). Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo. Journal of Biological Chemistry, 297 (1) 100834, 1-14. doi: 10.1016/j.jbc.2021.100834
Payne, Colton D., Franke, Bastian, Fisher, Mark F., Hajiaghaalipour, Fatemeh, McAleese, Courtney E., Song, Angela, Eliasson, Carl, Zhang, Jingjing, Jayasena, Achala S., Vadlamani, Grishma, Clark, Richard J., Minchin, Rodney F., Mylne, Joshua S. and Rosengren, K. Johan (2021). A chameleonic macrocyclic peptide with drug delivery applications. Chemical Science, 12 (19), 6670-6683. doi: 10.1039/d1sc00692d
Goncalves Monteiro, Daniela, van Dijk, Johannes W. A., Aliyanto, Randy, Fung, Eileen, Nemeth, Elizabeta, Ganz, Tomas, Rosengren, Johan and Clark, Richard J. (2021). Pursuing orally bioavailable hepcidin analogues via cyclic N-methylated mini-hepcidins. Biomedicines, 9 (2) 164, 1-14. doi: 10.3390/biomedicines9020164
Armstrong, David A., Jin, Ai-Hua, Braga Emidio, Nayara, Lewis, Richard J., Alewood, Paul F. and Rosengren, K. Johan (2021). Chemical synthesis and NMR solution structure of conotoxin GXIA from Conus geographus. Marine Drugs, 19 (2) 60, 1-14. doi: 10.3390/md19020060
Johnstone, Elizabeth K. M., See, Heng B., Abhayawardana, Rekhati S., Song, Angela, Rosengren, K. Johan, Hill, Stephen J. and Pfleger, Kevin D. G. (2021). Investigation of receptor heteromers using NanoBRET ligand binding. International Journal of Molecular Sciences, 22 (3) 1082, 1-16. doi: 10.3390/ijms22031082
Niederacher, Gerhard, Urwin, Debra, Dijkwel, Yasmin, Tremethick, David J., Rosengren, K. Johan, Becker, Christian F. W. and Conibear, Anne C. (2021). Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications. RSC Chemical Biology, 2 (2), 537-550. doi: 10.1039/d0cb00175a
Ho, Thao N. T., Lee, Han Siean, Swaminathan, Shilpa, Goodwin, Lewis, Rai, Nishant, Ushay, Brianna, Lewis, Richard J., Rosengren, K. Johan and Conibear, Anne C. (2021). Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Medicinal Chemistry, 12 (9), 1574-1584. doi: 10.1039/d1md00182e
Ali, Amanat, Johnstone, Elizabeth K. M., Baby, Bincy, See, Heng B., Song, Angela, Rosengren, K. Johan, Pfleger, Kevin D. G., Ayoub, Mohammed Akli and Vijayan, Ranjit (2020). Insights into the interaction of LVV-hemorphin-7 with angiotensin II type 1 receptor. International Journal of Molecular Sciences, 22 (1) 209, 209-14. doi: 10.3390/ijms22010209
Krumpe, Lauren R. H., Wilson, Brice A. P., Marchand, Christophe, Sunassee, Suthananda N., Bermingham, Alun, Wang, Wenjie, Price, Edmund, Guszczynski, Tad, Kelley, James A., Gustafson, Kirk R., Pommier, Yves, Rosengren, K. Johan, Schroeder, Christina I. and O'Keefe, Barry R. (2020). Recifin A, initial example of the Tyr-lock peptide structural family, is a selective allosteric inhibitor of Tyrosyl-DNA phosphodiesterase I. Journal of the American Chemical Society, 142 (50), 21178-21188. doi: 10.1021/jacs.0c10418
Payne, Colton D., Vadlamani, Grishma, Fisher, Mark F., Zhang, Jingjing, Clark, Richard J., Mylne, Joshua S. and Rosengren, K. Johan (2020). Defining the familial fold of the vicilin-buried peptide family. Journal of Natural Products, 83 (10), 3030-3040. doi: 10.1021/acs.jnatprod.0c00594
Praveen, Praveen, Tailhades, Julien, Rosengren, K. Johan, Liu, Mengjie, Wade, John D., Bathgate, Ross A. D. and Hossain, Mohammed Akhter (2020). Effects of C-Terminal B-Chain Modifications in a Relaxin 3 Agonist Analogue. ACS Medicinal Chemistry Letters, 11 (11) acsmedchemlett.0c00456, 2336-2340. doi: 10.1021/acsmedchemlett.0c00456
Fisher, Mark F., Payne, Colton D., Chetty, Thaveshini, Crayn, Darren M., Berkowitz, Oliver, Whelan, James, Rosengren, K. Johan and Mylne, Joshua S. (2020). The genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides. Journal of Biological Chemistry, 295 (42), 14510-14521. doi: 10.1074/jbc.ra120.014781
Lee, Han Siean, Wang, Shu Hui, Daniel, James T., Hossain, Mohammed Akhter, Clark, Richard J., Bathgate, Ross A. D. and Rosengren, K. Johan (2020). Exploring the use of helicogenic amino acids for optimising single chain relaxin-3 peptide agonists. Biomedicines, 8 (10) 415, 1-16. doi: 10.3390/biomedicines8100415
Gunasekera, Sunithi, Muhammad, Taj, Strömstedt, Adam A., Rosengren, K. Johan and Göransson, Ulf (2020). Backbone cyclization and dimerization of LL-37-derived peptides enhance antimicrobial activity and proteolytic stability. Frontiers in Microbiology, 11 168, 168. doi: 10.3389/fmicb.2020.00168
Lee, Han Siean, Postan, Michael, Song, Angela, Clark, Richard J., Bathgate, Ross A. D., Haugaard-Kedström, Linda M. and Rosengren, K. Johan (2020). Development of relaxin-3 agonists and antagonists based on grafted disulfide-stabilized scaffolds. Frontiers in Chemistry, 8 87, 87. doi: 10.3389/fchem.2020.00087
Bleackley, Mark R., Dawson, Charlotte S., Payne, Jennifer A.E., Harvey, Peta J., Rosengren, K. Johan, Quimbar, Pedro, Garcia-Ceron, Donovan, Lowe, Rohan, Bulone, Vincent, van der Weerden, Nicole L, Craik, David J. and Anderson, Marilyn A. (2019). The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins. The Cell Surface, 5 100026, 100026. doi: 10.1016/j.tcsw.2019.100026
Fisher, Mark F., Payne, Colton D., Rosengren, K. Johan and Mylne, Joshua S. (2019). An orbitide from Ratibida columnifera seed containing 16 amino acid residues. Journal of Natural Products, 82 (8) acs.jnatprod.9b00111, 2152-2158. doi: 10.1021/acs.jnatprod.9b00111
Conibear, Anne C., Rosengren, K. Johan, Becker, Christian F. W. and Kaehlig, Hanspeter (2019). Random coil shifts of posttranslationally modified amino acids. Journal of Biomolecular NMR, 73 (10-11), 587-599. doi: 10.1007/s10858-019-00270-4
Zhang, Jingjing, Payne, Colton D., Pouvreau, Benjamin, Schaefer, Hanno, Fisher, Mark F., Taylor, Nicolas L., Berkowitz, Oliver, Whelan, James, Rosengren, K. Johan and Mylne, Joshua S. (2019). An ancient peptide family buried within vicilin precursors. ACS Chemical Biology, 14 (5) acschembio.9b00167, 979-993. doi: 10.1021/acschembio.9b00167
Minchin, Rodney F., Rosengren, K. Johan, Burow, Rachel and Butcher, Neville J. (2018). Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate. Biochemical Pharmacology, 158, 153-160. doi: 10.1016/j.bcp.2018.10.013
Sousa, Silmara R., McArthur, Jeffrey R., Brust, Andreas, Bhola, Rebecca F., Rosengren, K. Johan, Ragnarsson, Lotten, Dutertre, Sebastien, Alewood, Paul F., Christie, Macdonald J., Adams, David J., Vetter, Irina and Lewis, Richard J. (2018). Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports, 8 (1) 13397, 13397. doi: 10.1038/s41598-018-31245-4
Wong, Lilian L. L., Scott, Daniel James, Hossain, Mohammed Akhter, Kaas, Quentin, Rosengren, K. Johan and Bathgate, Ross A. D. (2018). Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor. Journal of Biological Chemistry, 293 (41), 15777-15789. doi: 10.1074/jbc.ra118.002645
Haugaard-Kedström, Linda M., Lee, Han Siean, Jones, Maryon V., Song, Angela, Rathod, Vishaal, Hossain, Mohammed Akhter, Bathgate, Ross A.D. and Rosengren, K. Johan (2018). Binding conformation and determinants of a single chain peptide antagonist at the relaxin-3 receptor RXFP3. Journal of Biological Chemistry, 293 (41), 15765-15776. doi: 10.1074/jbc.ra118.002611
Armstrong, David A., Kaas, Quentin and Rosengren, K. Johan (2018). Prediction of disulfide dihedral angles using chemical shifts. Chemical Science, 9 (31), 6548-6556. doi: 10.1039/c8sc01423j
Gunasekera, Sunithi, Muhammad, Taj, Strömstedt, Adam A., Rosengren, K. Johan and Göransson, Ulf (2018). Front Cover: Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity (ChemBioChem 9/2018). ChemBioChem, 19 (9), 891-891. doi: 10.1002/cbic.201800188
Gunasekera, Sunithi, Muhammad, Taj, Strömstedt, Adam A., Rosengren, K. Johan and Göransson, Ulf (2018). Alanine and lysine scans of the LL-37 derived peptide fragment KR-12 reveal key residues for antimicrobial activity. Chembiochem : A European Journal of Chemical Biology, 19 (9), 931-939. doi: 10.1002/cbic.201700599
Jacobsson, Erik, Andersson, Håkan S., Strand, Malin, Peigneur, Steve, Eriksson, Camilla, Lodén, Henrik, Shariatgorji, Mohammadreza, Andrén, Per E., Lebbe, Eline K. M., Rosengren, K. Johan, Tytgat, Jan and Göransson, Ulf (2018). Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Scientific Reports, 8 (1) 4596, 4596. doi: 10.1038/s41598-018-22305-w
Franke, B., Mylne, J. S. and Rosengren, K. J. (2018). Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins. Natural Product Reports, 35 (2), 137-146. doi: 10.1039/c7np00066a
Park, Sungkyu, Yoo, Ki-Oug, Marcussen, Thomas, Backlund, Anders, Jacobsson, Erik, Rosengren, K. Johan, Doo, Inseok and Göransson, Ulf (2017). Cyclotide evolution: Insights from the analyses of their precursor sequences, structures and distribution in violets (viola). Frontiers in Plant Science, 8 2058, 1-19. doi: 10.3389/fpls.2017.02058
Franke, Bastian, James, Amy M., Mobli, Mehdi, Colgrave, Michelle L., Mylne, Joshua S. and Rosengren, K. Johan (2017). Two proteins for the price of one: structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1. The Journal of Biological Chemistry, 292 (30), 12398-12411. doi: 10.1074/jbc.M117.776955
Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883). Scientific Reports, 7 (1) 46816, 46816. doi: 10.1038/srep46816
Patil, Nitin A., Rosengren, K. Johan, Separovic, Frances, Wade, John D., Bathgate, Ross A. D. and Hossain, Mohammed Akhter (2017). Relaxin family peptides: structure-activity relationship studies. British Journal of Pharmacology, 174 (10), 950-961. doi: 10.1111/bph.13684
Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a. Scientific Reports, 7 (1) 40883, 40883. doi: 10.1038/srep40883
Franke, Bastian, Jayasena, Achala S., Fisher, Mark F., Swedberg, Joakim E., Taylor, Nicolas L., Mylne, Joshua S. and Rosengren, K. Johan (2016). Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana). Biopolymers, 106 (6), 806-817. doi: 10.1002/bip.22901
Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016). Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 (10), 2202-2212. doi: 10.1002/bit.25993
Franke, Bastian, Colgrave, Michelle L., Mylne, Joshua S. and Rosengren, K. Johan (2016). Mature forms of the major seed storage albumins in sunflower: a mass spectrometric approach. Journal of Proteomics, 147, 177-186. doi: 10.1016/j.jprot.2016.05.004
Hojo, Keiko, Hossain, Mohammed Akhter, Tailhades, Julien, Shabanpoor, Fazel, Wong, Lilian L. L., Ong-Palsson, Emma E. K., Kastman, Hanna E., Ma, Sherie, Gundlach, Andrew L., Rosengren, K. Johan, Wade, John D. and Bathgate, Ross A. D. (2016). Development of a single-chain peptide agonist of the relaxin-3 receptor using hydrocarbon stapling. Journal of Medicinal Chemistry, 59 (16), 7445-7456. doi: 10.1021/acs.jmedchem.6b00265
Hossain, Mohammed Akhter, Kocan, Martina, Yao, Song T., Royce, Simon G., Nair, Vinojini B., Siwek, Christopher, Patil, Nitin A., Harrison, Ian P., Rosengren, K. Johan, Selemidis, Stavros, Summers, Roger J., Wade, John D., Bathgate, Ross A. D. and Samuel, Chrishan S. (2016). A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1. Chemical Science, 7 (6), 3805-3819. doi: 10.1039/c5sc04754d
Patil, Nitin A., Hughes, Richard A., Rosengren, K. Johan, Kocan, Martina, Ang, Sheng Yu, Tailhades, Julien, Separovic, Frances, Summers, Roger J., Grosse, Johannes, Wade, John D., Bathgate, Ross A. D. and Hossain, Mohammed Akhter (2016). Engineering of a novel simplified human insulin-Like peptide 5 agonist. Journal of Medicinal Chemistry, 59 (5), 2118-2125. doi: 10.1021/acs.jmedchem.5b01786
Jayasena, Achala S., Franke, Bastian, Rosengren, Johan and Mylne,Joshua S. (2016). A tripartite approach identifies the major sunflower seed albumins. Theoretical and Applied Genetics, 129 (3), 613-629. doi: 10.1007/s00122-015-2653-3
Conibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1), 89-100. doi: 10.1002/bip.22767
Elliott, Alysha G., Franke, Bastian, Armstrong, David A., Craik, David J., Mylne, Joshua S. and Rosengren, K. Johan (2016). Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49 (1), 1-14. doi: 10.1007/s00726-016-2333-x
Burman, Robert, Yeshak, Mariamawit Y., Larsson, Sonny, Craik, David J., Rosengren, K. Johan and Goeransson, Ulf (2015). Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae. Frontiers in Plant Science, 6 (855) 855, 1-13. doi: 10.3389/fpls.2015.00855
Zhang, Carry, Chua, Berenice E., Yang, Annie, Shabanpoor, Fazel, Hossain, Mohammad Akhter, Wade, John D., Rosengren, K. Johan, Smith, Craig M. and Gundlach A.L. (2015). Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice. Behavioural Brain Research, 292, 125-132. doi: 10.1016/j.bbr.2015.06.010
Hossain, Mohammed Akhter, Haugaard-Kedstrom, Linda M., Rosengren, K. Johan, Bathgate, Ross A. D. and Wade, John D. (2015). Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability. Organic and Biomolecular Chemistry, 13 (44), 10895-10903. doi: 10.1039/c5ob01539a
Carstens, Bodil B., Rosengren, K. Johan, Gunasekera, Sunithi, Schempp, Stefanie, Bohlin, Lars, Dahlstrom, Mia, Clark, Richard J. and Goransson, Ulf (2015). Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barretti. Journal of Natural Products, 78 (8), 1886-1893. doi: 10.1021/acs.jnatprod.5b00210
Himeno, Kohei, Rosengren, K. Johan, Inoue, Tomoko, Perez, Rodney H., Colgrave, Michelle L., Lee, Han Siean, Chan, Lai Y., Henriques, Sonia Troeira, Fujita, Koji, Ishibashi, Naoki, Zendo, Takeshi, Wilaipun, Pongtep, Nakayama, Jiro, Leelawatcharamas, Vichien, Jikuya, Hiroyuki, Craik, David J. and Sonomoto, Kenji (2015). Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium. Biochemistry, 54 (31), 4863-4876. doi: 10.1021/acs.biochem.5b00196
Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178
de Veer, Simon J., Swedberg, Joakim E., Akcan, Muharrem, Rosengren, K. Johan, Brattsand, Maria, Craik, David J. and Harris, Jonathan M. (2015). Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. Biochemical Journal, 469 (2), 243-253. doi: 10.1042/BJ20150412
Haugaard-Kedstrom, Linda M, Wong, Lillian L. L, Bathgate, Ross A. D and Rosengren, K. Johan (2015). Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3. Amino Acids, 47 (6) 1961, 1267-1271. doi: 10.1007/s00726-015-1961-x
Aboye, Teshome L, Stromstedt, Adam A, Gunasekera, Sunithi, Bruhn, Jan G, El-Seedi, Hesham, Rosengren K.J. and Goransson, Ulf (2015). A cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. ChemBioChem, 16 (7), 1068-1077. doi: 10.1002/cbic.201402704
Haugaard-Kedstrom, Linda, Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A. D., Rinderknecht, Ernst, Wade, John D., Craik, David J. and Rosengren, Karl Johan (2015). Solution structure, aggregation behavior, and flexibility of human relaxin-2. ACS Chemical Biology, 10 (3), 891-900. doi: 10.1021/cb500918v
Gori, Alessandro, Wang, Ching-I A., Harvey, Peta J., Rosengren, K. Johan, Bhola, Rebecca F., Gelmi, Maria L., Longhi, Renato, Christie, Macdonald J., Lewis, Richard J., Alewood, Paul F. and Brust, Andreas (2015). Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic. Angewandte Chemie - International Edition, 54 (4), 1361-1364. doi: 10.1002/anie.201409678
Conibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014). Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 (49), 14257-14266. doi: 10.1021/jp507754c
Smith, Craig M., Chua, Berenice E., Zhang, Cary, Walker, Andrew W., Haidar, Mouna, Hawkes, David, Shabanpoor, Fazel, Hossain, Mohammad Akhter, Wade, John D., Rosengren, K. Johan and Gundlach, Andrew L. (2014). Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice. Behavioural Brain Research, 268, 117-126. doi: 10.1016/j.bbr.2014.03.037
Elliott, Alysha G., Delay, Christina, Liu, Huanle, Phua, Zaiyang, Rosengren, K. Johan, Benfield, Aurelie H., Panero, Jose L., Colgrave, Michelle L., Jayasena, Achala S., Dunse, Kerry M., Anderson, Marilyn A., Schilling, Edward E., Ortiz-Barrientos, Daniel, Craik, David J. and Mylne, Joshua S. (2014). Evolutionary origins of a bioactive peptide buried within preproalbumin. The Plant Cell, 26 (3), 981-995. doi: 10.1105/tpc.114.123620
Schroeder, Christina I., Swedberg, Joakim E., Withka, Jane M., Rosengren, K. Johan, Akcan, Muharrem, Clayton, Daniel J., Daly, Norelle L., Cheneval, Olivier, Borzilleri, Kris A., Griffor, Matt, Stock, Ingrid, Colless, Barbara, Walsh, Phillip, Sunderland, Phillip, Reyes, Allan, Dullea, Robert, Ammirati, Mark, Liu, Shenping, McClure, Kim F., Tu, Meihua, Bhattacharya, Samit K., Liras, Spiros, Price, David A. and Craik, David J. (2014). Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chemistry and Biology, 21 (2), 284-294. doi: 10.1016/j.chembiol.2013.11.014
Conibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014). The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 (3), 451-459. doi: 10.1002/cbic.201300568
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898
Jia, Xinying, Schulte, Leigh, Loukas, Alex, Pickering, Darren, Pearson, Mark, Mobli, Mehdi, Jones, Alun, Rosengren, Karl J., Daly, Norelle L., Gobert, Geoffrey N., Jones, Malcolm K., Craik, David J. and Mulvenna, Jason (2014). Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 (10), 1-26. doi: 10.1074/jbc.M113.531558
Jia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014). Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press (10), 1-25. doi: 10.1074/jbc.M113.539262
Jensen, Jonas E., Cristofori-Armstrong, Ben, Anangi, Raveendra, Rosengren, K. Johan, Lau, Carus H. Y., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2014). Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores. Journal of Medicinal Chemistry, 57 (21), 9195-9203. doi: 10.1021/jm501400p
Mylne, Joshua S., Hara-Nishimura, Ikuko and Rosengren, K. Johan (2014). Seed storage albumins: Biosynthesis, trafficking and structures. Functional Plant Biology, 41 (7), 671-677. doi: 10.1071/FP14035
Rosengren, K. Johan, Daly, Norelle L., Harvey, Peta J. and Craik, David J. (2013). The Self-Association of the Cyclotide Kalata B2 in Solution is Guided by Hydrophobic Interactions (vol 100, pg 453, 2013). Biopolymers, 102 (1), 136-136. doi: 10.1002/bip.22443
Ryan,Philip J., Kastman, Hanna E., Krstew, Elena V., Rosengren, K. Johan, Hossain, Mohammed Akhter, Churilov, Leonid, Wade, John D., Gundlach, Andrew L. and Lawrence, Andrew J. (2013). Relaxin-3/RXFP3 system regulates alcohol-seeking. Proceedings of the National Academy of Sciences of the United States of America, 110 (51), 20789-20794. doi: 10.1073/pnas.1317807110
Daly, Norelle L., Thorstholm, Louise, Greenwood, Kathryn P., King, Gordon J., Rosengren, K. Johan, Heras, Begona, Martin, Jennifer L. and Craik, David J. (2013). Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor. Journal of Biological Chemistry, 288 (50), 36141-36148. doi: 10.1074/jbc.M113.528240
Rosengren, K. Johan, Daly, Norelle L., Harvey, Peta J. and Craik, David J. (2013). The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions. Peptide Science, Accepted Article (5), 1-16. doi: 10.1002/bip.22269
Conibear, Anne C., Rosengren, K. Johan, Daly, Norelle L., Henriques, Sonia Troeira and Craik, David J. (2013). The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity. Journal of Biological Chemistry, 288 (15), 10830-10840. doi: 10.1074/jbc.M113.451047
Bathgate, Ross A. D., Oh, Maria H. Y., Ling, W. J. Jason, Kaas, Quentin, Hossain, M. Akhter, Gooley, Paul R. and Rosengren, K. Johan (2013). Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3. Frontiers in Endocrinology, 4 (FEB) article 13. doi: 10.3389/fendo.2013.00013
Ragnarsson, Lotten, Wang, Ching-I Anderson, Andersson, Asa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2013). Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor. Journal of Biological Chemistry, 288 (3), 1814-1827. doi: 10.1074/jbc.M112.430785
Conibear, Anne C., Rosengren, K. Johan, Harvey, Peta J. and Craik, David J. (2012). Structural characterization of the cyclic cystine ladder motif of θ-defensins. Biochemistry, 51 (48), 9718-9726. doi: 10.1021/bi301363a
Scott, Daniel J., Rosengren, K. Johan and Bathgate, Ross A. D. (2012). The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2. Molecular Endocrinology, 26 (11), 1896-1906. doi: 10.1210/me.2012-1188
Chan, Linda J., Rosengren, K. Johan, Layfield, Sharon L., Bathgate, Ross A. D., Separovic, Frances, Samuel, Chrishan S., Hossain, Mohammed A. and Wade, John D. (2012). Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin. Journal of Biological Chemistry, 287 (49), 41152-41164. doi: 10.1074/jbc.M112.409284
Goransson, Ulf, Burman, Robert, Gunasekera, Sunithi, Stromstedt, Adam A. and Rosengren, K. Johan (2012). Circular proteins from plants and fungi. Journal of Biological Chemistry, 287 (32), 27001-27006. doi: 10.1074/jbc.R111.300129
Bathgate, Ross A. D., Zhang, Soude, Hughes, Richard A., Rosengren, K. Johan and Wade, John D. (2012). The structural determinants of insulin-like peptide 3 activity. Frontiers in Endocrinology, 3 (FEB) Article 11, 11.1-11.10. doi: 10.3389/fendo.2012.00011
Bergman, I.-M., Edman, K., Ekdahl, K. N., Rosengren, K. J. and Edfors, I. (2012). Extensive polymorphism in the porcine Toll-like receptor 10 gene. International Journal of Immunogenetics, 39 (1), 68-76. doi: 10.1111/j.1744-313X.2011.01057.x
Andersson, Hakan S., Figueredo, Sharel M., Haugaard-Kedstrom, Linda M., Bengtsson, Elina, Daly, Norelle L., Qu, Xiaoqing, Craik, David J., Ouellette, Andre J. and Rosengren, K. Johan (2012). The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids, 43 (4), 1471-1483. doi: 10.1007/s00726-012-1220-3
Hossain, Mohammed Akhter, Rosengren, K. Johan, Samuel, Chrishan S., Shabanpoor, Fazel, Chan, Linda J., Bathgate, Ross A. D. and Wade, John D. (2011). The minimal active structure of human relaxin-2. Journal of Biological Chemistry, 286 (43), 37555-37565. doi: 10.1074/jbc.M111.282194
Henriques, Sónia Troeira, Huang, Yen-Hua, Rosengren, K. Johan, Franquelim, Henri G., Carvalho, Filomena A., Johnson, Adam, Sonza, Secondo, Tachedjian, Gilda, Castanho, Miguel A. R. B., Daly, Norelle L. and Craik, David J. (2011). Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. Journal of Biological Chemistry, 286 (27), 24231-24241. doi: 10.1074/jbc.M111.253393
Wang, Conan K. L., Clark, Richard J., Harvey, Peta J., Rosengren, K. Johan, Cemazar, Masa and Craik, David J. (2011). The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry, 50 (19), 4077-4086. doi: 10.1021/bi2004153
Haugaard-Kedström, Linda M., Shabanpoor, Fazel, Hossain, Mohammed Akhter, Clark, Richard J., Ryan, Philip J., Craik, David J., Gundlach, Andrew L., Wade, John D., Bathgate, Ross A. D. and Rosengren, K. Johan (2011). Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3. Journal of the American Chemical Society, 133 (13), 4965-4974. doi: 10.1021/ja110567j
Daly, Norelle L., Rosengren, K. Johan, Henriques, Sonia Troeira and Craik, David J. (2011). NMR and protein structure in drug design: Application to cyclotides and conotoxins. European Biophysics Journal, 40 (4), 359-370. doi: 10.1007/s00249-011-0672-9
Rosengren, K. Johan and Craik, David J. (2010). Peptide rope tricks. Chimica Oggi, 28 (6), 28-32.
Bergman, Ingrid-Maria, Rosengren, Johan K., Edman, Kjell and Edfors, Inger (2010). European wild boars and domestic pigs display different polymorphic patterns in the Toll-like receptor (TLR) 1, TLR2, and TLR6 genes. Immunogenetics, 62 (1), 49-52. doi: 10.1007/s00251-009-0409-4
Plan, Manuel R, Rosengren, K Johan, Sando, Lillian, Daly, Norelle L and Craik, David J (2010). Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis. Biopolymers, 94 (5), 647-658. doi: 10.1002/bip.21409
Rosengren, K. J. and Craik, D. J. (2009). How bugs make lassos. Chemistry and Biology, 16 (12), 1211-1212. doi: 10.1016/j.chembiol.2009.12.004
Nicholls, Ian A., Andersson, Hakan S., Charlton, Christy, Henschel, Henning, Karlsson, Bjorn C. G., Karlsson, Jesper G., O'Mahony, John, Rosengren, Annika M., Rosengren, K. Johan and Wikman, Susanne (2009). Theoretical and computational strategies for rational molecularly imprinted polymer design. Biosensors & Bioelectronics, 25 (3), 543-552. doi: 10.1016/j.bios.2009.03.038
Goransson, Ulf, Herrmann, Anders, Burman, Robert, Haugaard-Jonsson, Linda M. and Rosengren, K. Johan (2009). The conserved glu in the cyclotide cycloviolacin O2 has a key structural role. Chembiochem, 10 (14), 2354-2360. doi: 10.1002/cbic.200900342
Daly, N.L ., Rosengren, K. J. and Craik, D. J. (2009). Discovery, structure and biological activities of cyclotides. Advanced Drug Delivery Reviews, 61 (11), 918-930. doi: 10.1016/j.addr.2009.05.003
Haugaard-Jonsson, Linda M., Hossain, Mohammed Akhter, Daly, Norelle L., Craik, David J., Wade, John D. and Rosengren, K. Johan (2009). Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. Biochemical Journal, 419 (3), 619-627. doi: 10.1042/BJ20082353
Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T, Hajdu, J, Bohlin, L, Claeson, P, Goransson, U, Rosengren, K. J., Tang, J, Tan, N. H. and Craik, D. J. (2009). Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 284 (16), 10672-10683. doi: 10.1074/jbc.M900021200
Akhter Hossain, Mohammed, Bathgate, Ross A. D., Rosengren, K. Johan, Shabanpoor, Fazel, Zhang, Suode, Lin, Feng, Tregear, Geoffrey W. and Wade, John D. (2009). The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BΔ23-27)R/I5. Chemical Biology and Drug Design, 73 (1), 46-52. doi: 10.1111/j.1747-0285.2008.00756.x
Hossain, Mohammed Akhter, Rosengren, K. Johan, Zhang, Suode, Bathgate, Ross A. D., Tregear, Geoffrey W., van Lierop, Bianca J., Robinson, Andrea J. and Wade, John D. (2009). Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity. Organic & Biomolecular Chemistry, 7 (8), 1547-1553. doi: 10.1039/b821882j
Rosengren, K. Johan, Daly, Norelle L. and Craik, David J. (2009). NMR of Peptide Toxins. Annual Reports on NMR Spectroscopy, 68 (C), 89-147. doi: 10.1016/S0066-4103(09)06802-1
Haugaard-Jönsson, Linda M., Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A. D., Wade, John D., Craik, David J. and Rosengren, K. Johan (2008). Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist. The Journal of Biological Chemistry, 283 (35), 23811-23818. doi: 10.1074/jbc.M800489200
Hossain, Mohammed Akhter, Bathgate, Ross A. D., Kong, Chze K., Shabanpoor, Fazel, Suode Zhang, Haugaard-Jönsson, Linda M., Rosengren, K. Johan, Tregear, Geoffrey W. and Wade, John D. (2008). Synthesis, conformation, and activity of human insulin-like Peptide 5 (INSL5). ChemBioChem, 9 (11), 1816-1822. doi: 10.1002/cbic.200800113
Hossain, M. A., Rosengren, K. J., Haugaard-Jonsson, L. M., Zhang, S., Layfield, S., Ferraro, T., Daly, N. L., Tregear, G. W., Wade, J. D. and Bathgate, R. A. D. (2008). The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors. Journal of Biological Chemistry, 283 (25), 17287-17297. doi: 10.1074/jbc.M801911200
Simonsen, S. M., Sando, L., Rosengren, K. J., Wang, C. K., Colgrave, M. L., Daly, N. L. and Craik, D. J. (2008). Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. Journal of Biological Chemistry, 283 (15), 9805-9813. doi: 10.1074/jbc.M709303200
Mansson, Alf, Balaz, Martina, Albet-Torres, Nuria and Rosengren, K Johan (2008). In vitro assays of molecular motors: Impact of motor-surface interactions. Frontiers In Bioscience, 13 (15), 5732-5754. doi: 10.2741/3112
Daly, Norelle L., Chen, Y, Rosengren, KJ, Marx, UC, Phillips, ML, Waring, AJ, Wang, W, Lehrer, RI and Craik, David J. (2007). Retrocyclin-2: Structural analysis of a potent anti-HIV θ-defensin. Biochemistry, 46 (35), 9920-9928. doi: 10.1021/bi700720e
Rosengren, K. Johan, Daly, Norelle L., Fornander, Liselotte M., Jonsson, Linda M. H., Shirafuji, Yoshinori, Qu, Xiaoqing, Vogel, Hans J., Ouellette, Andre J. and Craik, David J. (2006). Structural and functional characterization of the conserved salt bridge in mammalian Paneth cell alpha-defensins - Solution structures of mouse cryptdin-4 AND (E15D)-cryptdin-4. Journal of Biological Chemistry, 281 (38), 28068-28078. doi: 10.1074/jbc.M604992200
Rosengren, K. J., Zhang, S., Lin, F., Daly, N. L., Scott, D. J., Hughes, R. A., Bathgate, R. A. D., Craik, D. J. and Wade, J. D. (2006). Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3. Journal of Biological Chemistry, 281 (38), 28287-28295. doi: 10.1074/jbc.M603829200
Rosengren, K. J., Lin, F., Bathgate, R. A. D., Tregear, G. W., Daly, N. L., Wade, J. D. and Craik, D. J. (2006). Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. Journal of Biological Chemistry, 281 (9), 5845-5851. doi: 10.1074/jbc.M511210200
Chen, Bin, Colgrave, Michelle L., Daly, Norelle L., Rosengren, K. Johan, Gustafson, Kirk R. and Craik, David J. (2005). Isolation and characterization of novel cyclotides from Viola hederaceae - Solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide. Journal of Biological Chemistry, 280 (23), 22395-22405. doi: 10.1074/jbc.M501737200
Jennings, Cameron V., Rosengren, K. Johan, Daly, Norelle L., Plan, Manuel, Stevens, Jackie, Scanlon, Martin J., Waine, Clement, Norman, David G., Anderson, Marilyn A. and Craik, David J. (2005). Isolation, solution structure, and insecticidal activity of Kalata B2, a circular protein with a twist: Do Mobius strips exist in nature?. Biochemistry, 44 (3), 851-860. doi: 10.1021/bi047837h
Tregear, G. W., Bathgate, R. A., Layfield, S., Ferraro, T., Gundlach, A., Ma, S., Lin, F., Hanson, N. F., Summers, R. J., Rosengren, J., Craik, D. J. and Wade, J. D. (2005). The chemistry and biology of human relaxin-3. Relaxin And Related Peptides: Fourth International Conference, 1041, 40-46. doi: 10.1196/annals.1282.008
Clark, R. J., Fischer, H., Dempster, L., Daly, N. L., Rosengren, K. J., Nevin, S. T., Meunier, F. A., Adams, D. J. and Craik, D. J. (2005). Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the alpha-conotoxin MII. Proceedings of The National Academy of Sciences of The United States of America, 102 (39), 13767-13772. doi: 10.1073/pnas.0504613102
Wade, JD, Lin, F, Rosengren, J, Craik, D, Otvos, L, Bathgate, R and Tregear, GW (2005). Structure and neurofunction of relaxin-3, the ancestral relaxin. Biopolymers, 80 (4), 538-538.
Craik, DJ, Rosengren, KJ, Sando, L and Simonsen, SM (2005). Threaded rings and complex topologies in novel antimicrobial peptides: Nature's bio-engineering templates. Biopolymers, 80 (4), 489-489.
Rosengren, K. J., Goransson, U., Otvos, L. and Craik, D. J. (2004). Cyclization of pyrrhocoricin retains structural elements crucial for the antimircobial activity of the native peptide. Biopolymers, 76 (5), 446-458. doi: 10.1002/bip.20159
Rosengren, K. Johan, Blond, Alain, Alfonso, Carlos, Tabet, Jean-Claude, Rebuffat, Sylvie and Craik, David J. (2004). Structure of thermolysin cleaved microcin J25: Extreme stability of a two-chain antimicrobial peptide devoid of covalent links. Biochemistry, 43 (16), 4696-4702. doi: 10.1021/bi0361261
Maemoto, A., Qu, Xiaoqing, Rosengren, K. J., Tanabe, H, Henschen-Edman, A., Craik, D. J. and Ouellette, A. J. (2004). Functional analysis of the a-defensin disulfide array in mouse cryptdin-4. The Journal of Biological Chemistry, 279 (42), 44188-44196. doi: 10.1074/jbc.M406154200
Rosengren, K. J., Daly, N. L., Plan, M. R., Waine, C. and Craik, D. J. (2003). Twists, knots, and rings in proteins: Structural definition of the cyclotide framework. Journal of Biological Chemistry, 278 (10), 8606-8616. doi: 10.1074/jbc.M211147200
Craik, D. J., Daly, N. L., Saska, I., Trabi, M. and Rosengren, K. J. (2003). Structures of naturally occurring circular proteins from bacteria. Journal of Bacteriology, 185 (14), 4011-4021. doi: 10.1128/JB.185.14.4011-4021.2003
Rosengren, K. J., Clark, R. J., Daly, N. L., Goransson, U., Jones, A. and Craik, D. J. (2003). Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. Journal of the American Chemical Society, 125 (41), 12464-12474. doi: 10.1021/JA0367703
Rosengren, K. J., Mcmanus, A. and Craik, D. J. (2002). The structural and functional diversity of naturally occurring antimicrobial peptides. Current Medicinal Chemistry - Anti-Infective Agents, 1 (4), 319-341. doi: 10.2174/1568012023354712
Kragol, Goran, Hoffmann, Ralf, Chattergoon, Michael A., Lovas, Sandor, Cudic, Mare, Bulet, Philippe, Condie, Barry A., Rosengren, K. Johan, Montaner, Luis J. and Otvos, Laszlo (2002). Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin. European Journal of Biochemistry, 269 (17), 4226-4237. doi: 10.1046/j.1432-1033.2002.03119.x
Rosengren, K. Johan, Wilson, David, Daly, Norelle L., Alewood, Paul F. and Craik, David J. (2002). Solution Structures of the cis- and trans-Pro30 Isomers of a Novel 38-Residue Toxin from the Venom of Hadronyche Infensa sp. that Contains a Cystine-Knot Motif within Its Four Disulfide Bonds. Biochemistry, 41 (10), 3294-3301. doi: 10.1021/bi011932y
Rosengren, K. J., Daly, N. L., Scanlon, M. J. and Craik, D. J. (2001). Solution structure of BSTI: A new trypsin inhibitor from skin secretions of Bombina bombina. Biochemistry, 40 (15), 4601-4609. doi: 10.1021/bi002623v
Korsinczky, M. L. J., Schirra, H. J., Rosengren, K. J., West, J., Condie, B. A., Otvos, L., Anderson, M. A. and Craik, D. J. (2001). Solution structures by H-1 NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant. Journal of Molecular Biology, 311 (3), 579-591. doi: 10.1006/jmbi.2001.4887
Conference Papers
Zhao, Tianjiao, Rosengren, Johan K., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Structure-function of the spider peptide ProTx-III. Venom to Drugs, Daydream Island, QLD Australia, 15-19 March 2021.
Johnstone, E. K., See, H. B., Abhayawardana, R. S., Song, A., Rosengren, K. J., Hill, S. J. and Pfleger, K. D. (2019). Detection and characterisation of GPCR heteromers using NanoBRET ligand binding. British-Pharmacology-Society Meeting (Pharmacology), London, United Kingdom, 18-20 December 2018. Oxford, United Kingdom: John Wiley & Sons .
Zhao, Tianjiao, Rosengren, K. Johan, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.
Jacobsson, E., Andersson, H. S., Strand, M., Lebbe, E., Eriksson, C., Peigneur, S., Rosengren, J., Tytgat, J. and Goransson, U. (2016). Peptide toxins from the longest animal on earth. 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF, Copenhagen Denmark, Jul 24-27, 2016. STUTTGART: GEORG THIEME VERLAG KG. doi: 10.1055/s-0036-1596160
Andersson, H. S., Jacobsson, E., Eriksson, C., Hedstrom, M., Seth, H., Sundberg, P., Rosengren, K. J., Strand, M. and Goransson, U. (2016). The toxicity of ribbon worms: Alpha-nemertides or tetrodotoxin, or both?. 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF, Copenhagen Denmark, Jul 24-27, 2016. STUTTGART: GEORG THIEME VERLAG KG. doi: 10.1055/s-0036-1596617
Goncalves, Daniela, Rishi, Gautam, Aliyanto, Randy, Rosengren, Johan, Subramaniam, Nathan, Frazer, David and Clark, Richard (2016). Development of peptide therapeutics for iron disorders. 6th Meeting of the International BioIron Society, Zhejiang University, Hangzhou, China, 8-10 September 2015. Hoboken, NJ, United States: John Wiley & Sons.
Hojo, K., Hossain, M. A., Rosengren, K. J., Ma, S., Gundlach, A. L., Tsuda, Y., Hidaka, K., Bathgate, R. A. and Wade, J. D. (2016). Design, synthesis and biological activity of hydrocarbon stapled single-chain relaxin-3 analogue. 34th European Peptide Symposium and 8th International Peptide Symposium, Leipzig, Germany, 4-9 September 2016. Oxford, United Kingdom: John Wiley & Sons.
Franke, B., James, A., Mobli, M., Mylne, J. S. and Rosengren, K. J. (2016). Structural Features of An Unusual Sun-Flower Proalbumin Protein That Gives Rise to a Small Cyclic Peptide and a Seed Storage Protein. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. HOBOKEN: Wiley.
Cardoso, F. C., Dekan, Z., Anangi, R., Rosengren, K. J., Erickson, A., Vetter, I., Herzig, V., Alewood, P., King, G. F. and Lewis, R. J. (2014). Discovery of voltage-gated sodium channel inhibitors from tarantula venoms. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.
Rosengren, K. J., Elliott, A. G., Franke, B. and Mylne, J. S. (2014). Structural Diversity of a Novel Family of Cyclic Plant Peptides. 33rd European Peptide Symposium, Sofia Bulgaria, August 31 – September 5 2014. United Kingdom: John Wiley & Sons.
Brust, A., Gori, A., Wang, C-I A., Harvey, P. J., Rosengren, K. J., Gelmi, M. L., Longh, R., Lewis, R. J. and Alewood, P. F. (2014). SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID. 33rd European Peptide Symposium, Sofia, Bulgaria, 31 August – 5 September 2014. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2687
Rosengren, K. J., Haugaard-Kedstroem, L. M., Jones, M., Clark, R. J. and Bathgate, R. A. D. (2012). Novel single-chain ligands for the relaxin-3 receptor RXFP3. 32nd European Peptide Symposium "Peptides 2012", Athens, Greece, 02-07 September 2012. West Sussex, United Kingdom: John Wiley and Sons. doi: 10.1002/psc.2448
Ragnarsson, Lotten, Wang, Ching-I. Anderson, Andersson, Åsa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2012). The allosteric binding site for rho-TIA on the extracellular surface of the alpha 1B-Adrenoceptor. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.137
Henriques, Sonia Troeira, Huang, Yen-Boa, Rosengren, K. Johan, Franquelim, Henri G., Carvalho, Filomena A., Johnson, Adam, Sonza, Second, Tachedjian, Gilda, Castanho, Miguel A. R. B., Daly, Norelle L. and Craik, I. David J. (2011). Differences in bactericidal, hemolytic and anti-HIV efficiencies of the cyclotide kalata B1 are explained by distinct cell membrane compositions. 22nd American Peptide Symposium, San Diego, California, 25-30 June 2011 . Hoboken, NJ, United States: John Wiley & Sons.
Manuel Plan, Rosengren, K. Johan, Sando, Lillian, Daly, Norelle L. and Craik, David J. (2010). Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, 18-21 October 2009. Hoboken, N. J., U.S.: John Wiley & Sons. doi: 10.1002/bip.21409
Haugaard-Kedstrom, M., Hossain, M. A., Daly, N. L., Bathgate, R. A. D., Craik, D. J., Wade, J. D. and Rosengren, K. J. (2010). Characterisation of the human INSL5 solution structure. EPS 2010: The 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Bognor Regis, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1303
Haugaard-Kedström, M., Hossain, M. A., Daly, N. L., Bathgate, R. A. D., Wade, J. D., Craik, D. J. and Rosengren, K. J. (2010). Structural characterization of the relaxin-3IINSL5 chimera peptide: A selective RXFP3 and RXFP4 agonist. EPS 2010: The 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Bognor Regis, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1301
Rosengren, K. Johan, Bathgate, Ross A. D., Craik, David J., Daly, Norelle L., Haugaard-Jonsson, Linda M., Hossain, Mohammed Akhter and Wade, John D. (2009). Structural insights into the function of relaxins. Relaxin and Related Peptides Fifth International Conference, Maui, Hawaii, USA, 18-23 May, 2008. New York, U.S.A.: The Academy. doi: 10.1111/j.1749-6632.2009.03833.x
Haugaard-Jonsson, Linda M., Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A. D., Wade, John D., Craik, David J. and Rosengren, K. Johan (2009). Structural properties of relaxin chimeras: NMR characterization of the R3/I5 relaxin peptide. Relaxin and Related Peptides Fifth International Conference, Maui, Hawaii, USA, 18-23 May, 2008. New York, U.S.A.: The Academy. doi: 10.1111/j.1749-6632.2008.03805.x
Daly, Norelle L., Yi, Chen K., Rosengren, K. Johan, Marx, Ute C., Phillips, Martin L., Waring, Alan J., Wang, Wei, Lehrer, Robert I. and Craik, David J. (2009). Retrocyclin-2: A potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif. 20th American Peptide Society Symposium, Montreal, Canada, 26-30 June 2007. New York, United States: Springer New York LLC. doi: 10.1007/978-0-387-73657-0_254
Craik, David J., Rosengren, K. Johan, Sando, Lillian and Simonsen, Shane S. (2006). Threaded rings and complex topologies in antimicrobial peptides: Nature's engineering templates. 19th American Peptide Symposium, San Diego, CA, United States, 18-23 June 2005. New York, United States: Springer. doi: 10.1007/978-0-387-26575-9_101
Rosengren, KJ, Jen, FEC, Clark, RJ, Goransson, U, Daly, NL and Craik, DJ (2005). A novel threaded ring structure for the antimicrobial peptide microcin J25. Peptides 2004: 3rd International Peptide Symposium / 28th European Peptide Symposium, Prague, Czech Republic, 5 - 10 September 2004. Geneva, Switzerland: Kenes International.
Craik, David J., Daly, Norelle L., Colgrave, Michelle L. and Rosengren, K. Johan (2004). Discovery and applications of the cyclotides: Circular proteins from plants. 18th American Peptide Symposium, Boston, MA, U.S.A., 19-23 July 2003. Washington, DC, USA: American Chemical Society.
Plan, MR, Goransson, U, Rosengren, KJ, Clark, RJ, Daly, NL, Evert, P, Chen, C, Cagauan, AG and Craik, DJ (2004). Cyclotides: Novel Peptidic Pesticides for Plant Protection. CHICHESTER: JOHN WILEY & SONS LTD.
Clark, RJ, Dempster, L, Daly, NL, Rosengren, KJ and Craik, DJ (2004). Design, Synthesis and Structural Studies of Cyclic Alpha-Conotoxins. CHICHESTER: JOHN WILEY & SONS LTD.
Craik, D. J., Rosengren, K. J., Clark, R. J., Daly, N. L. and Goransson, U. (2004). A novel threaded ring structure for the antimicrobial peptide microcin J25. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5–10 September 2004. West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.617
Thesis
Rosengren, Karl Johan (2003). Twists, knots and rings : structural features of antimicrobial peptides. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi: 10.14264/253396