Dr Lachlan Harris
Honorary Research Fellow
School of Biomedical Sciences
QIMR Berghofer
Journal Articles
Rigo, Piero, Ahmed-de-Prado, Sara, Johnston, Rebecca L., Choudhury, Chandra, Guillemot, François and Harris, Lachlan (2025). Sequential transcriptional programs underpin activation of hippocampal stem cells. Science Advances, 11 (24) eadu4523, eadu4523-24. doi: 10.1126/sciadv.adu4523
Kordowski, Anja, Mulay, Onkar, Tan, Xiao, Vo, Tuan, Baumgartner, Ulrich, Maybury, Mellissa K., Hassall, Timothy, Harris, Lachlan, Nguyen, Quan and Day, Bryan W. (2025). Spatial analysis of a complete DIPG-infiltrated brainstem reveals novel ligand-receptor mediators of tumour-to-TME crosstalk. Acta Neuropathologica Communications, 13 (1) 35, 35. doi: 10.1186/s40478-025-01952-x
Li, Yuchen, Lim, Chaemin, Dismuke, Taylor, Malawsky, Daniel S., Oasa, Sho, Bruce, Zara C., Offenhäuser, Carolin, Baumgartner, Ulrich, D’Souza, Rochelle C. J., Edwards, Stacey L., French, Juliet D., Ock, Lucy S. H., Nair, Sneha, Sivakumaran, Haran, Harris, Lachlan, Tikunov, Andrey P., Hwang, Duhyeong, Alicea Pauneto, Coral Del Mar, Maybury, Mellissa, Hassall, Timothy, Wainwright, Brandon, Kesari, Santosh, Stein, Gregory, Piper, Michael, Johns, Terrance G., Sokolsky-Papkov, Marina, Terenius, Lars, Vukojević, Vladana, McSwain, Leon F. ... Day, Bryan W. (2025). Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179. Nature Communications, 16 (1) 1091, 1091-1. doi: 10.1038/s41467-024-54861-3
Currey, Laura, Harris, Lachlan and Piper, Michael (2024). Single cell transcriptomics of the cerebral cortex of mice lacking the PRC2 gene eed. BMC Research Notes, 17 (1) 382, 382. doi: 10.1186/s13104-024-07008-y
Friess, Dana, Brauer, Stephanie, Pöysti, Anni, Choudhury, Chandra and Harris, Lachlan (2024). Tools to study neural and glioma stem cell quiescence. Trends in Neurosciences, 47 (9), 736-748. doi: 10.1016/j.tins.2024.07.004
Currey, Laura, Mitchell, Benjamin, Al-Khalily, Majd, McElnea, Sarah-Jayne, Kozulin, Peter, Harkins, Danyon, Pelenyi, Alexandra, Fenlon, Laura, Suarez, Rodrigo, Kurniawan, Nyoman D, Burne, Thomas H., Harris, Lachlan, Thor, Stefan and Piper, Michael (2024). Polycomb repressive complex 2 is critical for mouse cortical glutamatergic neuron development. Cerebral Cortex, 34 (7) bhae268, 1-17. doi: 10.1093/cercor/bhae268
Kooblall, Kreepa G., Stevenson, Mark, Stewart, Michelle, Harris, Lachlan, Zalucki, Oressia, Dewhurst, Hannah, Butterfield, Natalie, Leng, Houfu, Hough, Tertius A., Ma, Da, Siow, Bernard, Potter, Paul, Cox, Roger D., Brown, Stephen D. M., Horwood, Nicole, Wright, Benjamin, Lockstone, Helen, Buck, David, Vincent, Tonia L., Hannan, Fadil M., Bassett, J.H. Duncan, Williams, Graham R., Lines, Kate E., Piper, Michael, Wells, Sara, Teboul, Lydia, Hennekam, Raoul C. and Thakker, Rajesh V. (2023). A mouse model with a frameshift mutation in the nuclear factor I/X (NFIX) gene has phenotypic features of Marshall‐Smith Syndrome. JBMR Plus, 7 (6) e10739, 1-14. doi: 10.1002/jbm4.10739
Sanchez Vega, M., Harris, L., Chong, S. and Burne, T. (2022). Interaction of developmental vitamin D deficiency and ethanol exposure on maternal metabolism and neonatal gene expression. Trends in Developmental Biology, 14, 33-52.
Austin, Sophie H. L., Gabarró-Solanas, Rut, Rigo, Piero, Paun, Oana, Harris, Lachlan, Guillemot, François and Urbán, Noelia (2021). Wnt/beta-catenin signalling is dispensable for adult neural stem cell homeostasis and activation. Development, 148 (20) dev199629. doi: 10.1242/dev.199629
Harris, Lachlan, Rigo, Piero, Stiehl, Thomas, Gaber, Zachary B., Austin, Sophie H. L., Masdeu, Maria Del Mar, Edwards, Amelia, Urbán, Noelia, Marciniak-Czochra, Anna and Guillemot, François (2021). Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population. Cell Stem Cell, 28 (5), 863-876.e6. doi: 10.1016/j.stem.2021.01.003
Bottes, Sara, Jaeger, Baptiste N., Pilz, Gregor-Alexander, Jörg, David J., Cole, John Darby, Kruse, Merit, Harris, Lachlan, Korobeynyk, Vladislav I., Mallona, Izaskun, Helmchen, Fritjof, Guillemot, François, Simons, Benjamin D. and Jessberger, Sebastian (2021). Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging. Nature Neuroscience, 24 (2), 225-233. doi: 10.1038/s41593-020-00759-4
Arber, Charles, Lovejoy, Christopher, Harris, Lachlan, Willumsen, Nanet, Alatza, Argyro, Casey, Jackie M., Lines, Georgie, Kerins, Caoimhe, Mueller, Anika K., Zetterberg, Henrik, Hardy, John, Ryan, Natalie S., Fox, Nick C., Lashley, Tammaryn and Wray, Selina (2021). Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis. Cell Reports, 34 (2) 108615, 1-18. doi: 10.1016/j.celrep.2020.108615
Matuzelski, Elise, Essebier, Alexandra, Harris, Lachlan, Gronostajski, Richard M., Harvey, Tracey J. and Piper, Michael (2020). Alterations in gene expression in the spinal cord of mice lacking Nfix. BMC Research Notes, 13 (1) 437, 437. doi: 10.1186/s13104-020-05278-w
Oishi, Sabrina, Zalucki, Oressia, Sanchez Vega, Michelle, Harkins, Danyon, Harvey, Tracey J., Kasherman, Maria, Davila, Raul A., Hale, Lauren, White, Melissa, Piltz, Sandra, Thomas, Paul, Burne, Thomas H.J., Harris, Lachlan and Piper, Michael (2020). Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1. Genes, Brain and Behavior, 19 (4) e12637, e12637. doi: 10.1111/gbb.12637
Zalucki, Oressia, Harris, Lachlan, Harvey, Tracey J., Harkins, Danyon, Widagdo, Jocelyn, Oishi, Sabrina, Matuzelski, Elise, Yong, Xuan Ling Hilary, Schmidt, Hannes, Anggono, Victor, Burne, Thomas H. J., Gronostajski, Richard M. and Piper, Michael (2019). NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular–subventricular zone. Cerebral Cortex, 29 (8), 3590-3604. doi: 10.1093/cercor/bhy233
Harris, Lachlan and Guillemot, François (2019). HES1, two programs: Promoting the quiescence and proliferation of adult neural stem cells. Genes and Development, 33 (9-10), 479-481. doi: 10.1101/gad.325761.119
Oishi, Sabrina, Harkins, Danyon, Kurniawan, Nyoman D., Kasherman, Maria, Harris, Lachlan, Zalucki, Oressia, Gronostajski, Richard M., Burne, Thomas H.J. and Piper, Michael (2018). Heterozygosity for Nuclear Factor One X in mice models features of Malan syndrome. EBioMedicine, 39, 388-400. doi: 10.1016/j.ebiom.2018.11.044
Zalucki, Oressia, Harkins, Danyon, Harris, Lachlan, Burne, Thomas H. J., Gronostajski, Richard M. and Piper, Michael (2018). Analysis of hippocampal-dependent learning and memory behaviour in mice lacking Nfix from adult neural stem cells. BMC Research Notes, 11 (1) 564, 564. doi: 10.1186/s13104-018-3652-7
Harris, Lachlan, Zalucki, Oressia and Piper, Michael (2018). Correction to: BrdU/EdU dual labeling to determine the cell-cycle dynamics of defined cellular subpopulations. Journal of Molecular Histology, 49 (4), 447-447. doi: 10.1007/s10735-018-9783-2
Harris, Lachlan, Zalucki, Oressia, Gobius, Ilan, McDonald, Hannah, Osinki, Jason, Harvey, Tracey J., Essebier, Alexandra, Vidovic, Diana, Gladwyn-Ng, Ivan, Burne, Thomas H., Heng, Julian I., Richards, Linda J., Gronostajski, Richard M. and Piper, Michael (2018). Erratum: Correction: Transcriptional regulation of intermediate progenitor cell generation during hippocampal development (doi: 10.1242/dev.140681) (Development (Cambridge, England) (2016) 143 24 (4620-4630) PII: dev169631). Development (Cambridge), 145 (14). doi: 10.1242/dev.169631
Harris, Lachlan, Zalucki, Oressia and Piper, Michael (2018). BrdU/EdU dual labeling to determine the cell-cycle dynamics of defined cellular subpopulations. Journal of Molecular Histology, 49 (3), 229-234. doi: 10.1007/s10735-018-9761-8
Harris, Lachlan, Zalucki, Oressia, Clément, Olivier, Fraser, James, Matuzelski, Elise, Oishi, Sabrina, Harvey, Tracey J., Burne, Thomas H. J., Heng, Julian Ik-Tsen, Gronostajski, Richard M. and Piper, Michael (2018). Neurogenic differentiation by hippocampal neural stem and progenitor cells is biased by NFIX expression. Development (Cambridge, England), 145 (3) dev155689, 1-12. doi: 10.1242/dev.155689
Bunt, Jens, Osinski, Jason M., Lim, Johnathon W. C., Vidovic, Diana, Ye, Yunan, Zalucki, Oressia, O'Connor, Timothy R., Harris, Lachlan, Gronostajski, Richard M., Richards, Linda J. and Piper, Michael (2017). Combined allelic dosage of Nfia and Nfib regulates cortical development. Brain and Neuroscience Advances, 1, 239821281773943. doi: 10.1177/2398212817739433
Matuzelski, Elise, Bunt, Jens, Harkins, Danyon, Lim, Jonathan W. C., Gronostajski, Richard M., Richards, Linda J., Harris, Lachlan and Piper, Michael (2017). Transcriptional regulation of Nfix by NFIB drives astrocytic maturation within the developing spinal cord. Developmental Biology, 432 (2), 286-297. doi: 10.1016/j.ydbio.2017.10.019
Harris, Lachlan, Zalucki, Oressia, Oishi, Sabrina, Burne, Thomas H., Jhaveri, Dhanisha J. and Piper, Michael (2017). A morphology independent approach for identifying dividing adult neural stem cells in the mouse hippocampus. Developmental Dynamics, 247 (1), 194-200. doi: 10.1002/dvdy.24545
Chen, Kok-Siong, Harris, Lachlan, Lim, Jonathan W. C. , Harvey, Tracey J. , Piper, Michael, Gronostajski, Richard M. , Richards, Linda J. and Bunt, Jens (2017). Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice. Journal of Comparative Neurology, 525 (11), 2465-2483. doi: 10.1002/cne.24206
Fane, Mitchell E., Chhabra, Yash, Hollingsworth, David E. J., Simmons, Jacinta L., Spoerri, Loredana, Oh, Tae Gyu, Chauhan, Jagat, Chin, Toby, Harris, Lachlan, Harvey, Tracey J., Muscat, George E. O., Goding, Colin R., Sturm, Richard A., Haass, Nikolas K., Boyle, Glen M., Piper, Michael and Smith, Aaron G. (2017). NFIB mediates BRN2 driven melanoma cell migration and invasion through regulation of EZH2 and MITF. EBioMedicine, 16, 63-75. doi: 10.1016/j.ebiom.2017.01.013
Fane, Mitchell, Harris, Lachlan, Smith, Aaron G. and Piper, Michael (2017). Nuclear factor one transcription factors as epigenetic regulators in cancer. International Journal of Cancer, 140 (12), 2634-2641. doi: 10.1002/ijc.30603
Harris, Lachlan, Zalucki, Oressia, Gobius, Ilan, McDonald, Hannah, Osinki, Jason, Harvey, Tracey J., Essebier, Alexandra, Vidovic, Diana, Gladwyn-Ng, Ivan, Burne, Thomas H., Heng, Julian I., Richards, Linda J., Gronostajski, Richard M. and Piper, Michael (2016). Transcriptional regulation of intermediate progenitor cell generation during hippocampal development. Development, 143 (24), 4620-4630. doi: 10.1242/dev.140681
Harris, Lachlan, Zalucki, Oressia, Piper, Michael and Heng, Julian Ik-Tsen (2016). Insights into the biology and therapeutic applications of neural stem cells. Stem Cells International, 2016 (1) 9745315, 9745315-18. doi: 10.1155/2016/9745315
Heng, Yee Hsieh Evelyn, Zhou, Bo, Harris, Lachlan, Harvey, Tracey, Smith, Aaron, Horne, Elise, Martynoga, Ben, Andersen, Jimena, Achimastou, Angeliki, Cato, Kathleen, Richards, Linda J., Gronostajski, Richard M., Yeo, Giles S., Guillemot, François, Bailey, Timothy L. and Piper, Michael (2015). NFIX regulates proliferation and migration within the murine SVZ neurogenic niche. Cerebral Cortex, 25 (10), 3758-3778. doi: 10.1093/cercor/bhu253
Vidovic, Diana, Harris, Lachlan, Harvey, Tracey J., Heng, Yee Hsieh Evelyn, Smith, Aaron G., Osinski, Jason, Hughes, James, Thomas, Paul, Gronostajski, Richard M., Bailey, Timothy L. and Piper, Michael (2015). Expansion of the lateral ventricles and ependymal deficits underlie the hydrocephalus evident in mice lacking the transcription factor NFIX. Brain Research, 1616, 71-87. doi: 10.1016/j.brainres.2015.04.057
Harris, Lachlan, Genovesi, Laura A., Gronostajski, Richard M., Wainwright, Brandon J. and Piper, Michael (2015). Nuclear factor one transcription factors: divergent functions in developmental versus adult stem cell populations. Developmental Dynamics, 244 (3), 227-238. doi: 10.1002/dvdy.24182
Piper, Michael, Barry, Guy, Harvey, Tracey J., McLeay, Robert, Smith, Aaron G., Harris, Lachlan, Mason, Sharon, Stringer, Brett W., Day, Bryan W., Wray, Naomi R., Gronostajski, Richard M., Bailey, Timothy L., Boyd, Andrew W. and Richards, Linda J. (2014). NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical development. Journal of Neuroscience, 34 (8), 2921-2930. doi: 10.1523/JNEUROSCI.2319-13.2014
Harris, Lachlan, Dixon, Chantelle, Cato, Kathleen, Heng, Yee Hsieh Evelyn, Kurniawan, Nyoman D., Ullmann, Jeremy F. P., Janke, Andrew L., Gronostajski, Richard M., Richards, Linda J., Burne, Thomas H. J. and Piper, Michael (2013). Heterozygosity for Nuclear Factor One X Affects Hippocampal-Dependent Behaviour in Mice. PLoS ONE, 8 (6) e65478, e65478. doi: 10.1371/journal.pone.0065478
Piper, Michael, Harris, Lachlan, Barry, Guy, Heng, Yee Hsieh Evelyn, Plachez, Celine, Gronostajski, Richard M. and Richards, Linda J. (2011). Nuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellum. The Journal of Comparative Neurology, 519 (17), 3532-3548. doi: 10.1002/cne.22721
Conference Papers
Dsouza, Rochelle, Skarne, Niclas, Mulay, Onkar, Harris, Lachlan, Holton, Emily, Zaman, Ashraf, Akgul, Seckin, Offenhauser, Carolin, Alexander, Hamish, Lwin, Zarnie, Jeffree, Rosalind, Inglis, Po-Ling, Powell, Joseph, Nguyen, Quan, Boyd, Andrew and Day, Bryan (2024). Targeting EPHA3 and EPHRIN A5: Advanced Precision Therapy For GBM. 2024 Society for Neuro-Oncology’s 29th Annual Meeting and Education Day, Houston, TX United States, 21-24 November 2024. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/neuonc/noae165.0941
Kordowski, Anja, Mulay, Onkar, Harris, Lachlan, Nguyen, Quan H and Day, Bryan W. (2024). Spatial Transcriptomic Sequencing Of A DIPG Patient Tumour Resource. 2024 International Symposium on Pediatric Neuro-Oncology (ISPNO), Philadelphia, PA United States, 29 June – 2 July 2024. Cary, NC United States: Oxford University Press. doi: 10.1093/neuonc/noae064.102
Currey, Laura, Mitchell, Benjamin, Harris, Lachlan, Thor, Stefan and Piper, Michael (2023). Polycomb Protein EED Regulates Identity Of Glutamatergic Neurons. IBRO 11th World Congress of Neuroscience, Granada, Spain, 9-13 September 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.ibneur.2023.08.045
Thesis
Harris, Lachlan Ian (2017). The function of NFIX during developmental and adult neurogenesis. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2017.863