Professor Chen Chen heads the endocrinology and metabolism lab.
Publications
Book Chapters
Huang, Lili, Huang, Zhengxiang, Chen, Yang and Chen, Chen (2020). Neuroendocrine and metabolic regulation of plasma growth hormone secretory profiles. Neurosecretion: secretory mechanisms. (pp. 195-218) edited by Jose R. Lemos, Govindan Dayanithi. Cham, Switzerland: Springer Nature Switzerland. doi: 10.1007/978-3-030-22989-4_10
Steyn, Frederik J. and Chen, Chen (2013). Adiponectin. Handbook of biologically active peptides. (pp. 983-989) edited by Abba J. Kastin. Amsterdam, Netherlands: Academic Press/Elsevier. doi: 10.1016/B978-0-12-385095-9.00130-5
Fung, Jenny N.T. and Chen, Chen (2012). Endometrial cancer: diagnosis, treatment and prevention. Horizons in cancer research. Volume 49. (pp. 1-32) edited by Hiroto S. Watanabe. Hauppauge, NY, USA: Nova Publishers.
Zhao, Yufeng and Chen, Chen (2011). Adipsin as an adipokine. Adipokines. (pp. 20-28) edited by Victor R. Preedy and Ross J. Hunter. Enfield, NH, United States: Science Publishers.
Chen, Chen (2002). Cell biology and membrane function. Textbook of Medical Physiology. (pp. 7-26) China: People's Health Press.
Chen, Chen and Clarke, Iain J. (1999). Intracellular GHRP signalling. Growth hormone secretagogues: basic findings and clinical implications. (pp. 53-63) edited by E. Ghigo, M. Boghen, F. F. Casanueva and C. Dieguez. Amsterdam, The Netherlands: Elsevier.
Chen, Chen (1998). Introduction of a new laboratory technique to investigate roles of intracellular signal pathways in the regulation of cell membrane ion channels. Proceedings of Chinese Academy of Medical Sciences. (pp. 1-26) Beijing, China: Peking Union Medical College and Chinese Academy of Medical Sciences.
Lledo, Pierre-Marie, Kukstas, Lucy A., Chen, Chen, Vincent, Jean-Didier and Israel, Jean-Marc (1990). Ionic currents in the regulation of stimulus-secretion coupling in normal and tumoral adenohypophyseal cells. Recent advances in basic and clinical neuroendocrinology. (pp. 65-74) edited by F. F. Casanueva and C. Dieguez. Amsterdam, The Netherlands: Elsevier Science Publishers.
Journal Articles
Bo, Surina, Dan, Mu, Li, Wei and Chen, Chen (2024). The regulatory mechanism of natural polysaccharides in type 2 diabetes mellitus treatment. Drug Discovery Today, 29 (11) 104182, 104182. doi: 10.1016/j.drudis.2024.104182
Hu, Huiming, Wang, Shuwen and Chen, Chen (2024). Pathophysiological role and potential drug target of NLRP3 inflammasome in the metabolic disorders. Cellular Signalling, 122 111320, 111320. doi: 10.1016/j.cellsig.2024.111320
Wang, Weihao, Wei, Ran, Xiao, Pei, Jiang, Xun, Chen, Zihao, Huang, Jinghe, Ma, Yanhua, Gao, Danni, Shao, Jian, Yu, Jun, Zhou, Kaixin, Chen, Chen, Li, Ying, Pan, Ying, Pan, Qi, Jia, Tong and Guo, Lixin (2024). Deep Contrast Clustering Analysis to Distinguish Diabetic Complications in Elderly Chinese Patients. Diabetes/metabolism research and reviews, 40 (7) ARTN e70000. doi: 10.1002/dmrr.70000
Zhao, Meijun, Liu, Chang, Liu, Zhenye, Zuo, Yuanyuan, Chen, Chen, Shi, Shuai, Shi, Xinlin, Xie, Yining, Yang, Huiying and Chen, Yutong (2024). Myocardium-targeted liposomal delivery of the antioxidant peptide 8P against doxorubicin-induced myocardial injury. International Journal of Pharmaceutics, 663 124569, 124569. doi: 10.1016/j.ijpharm.2024.124569
Liu, Kun, Li, Yuemeng, Yin, Fanxing, Wu, Xiaoyu, Zhang, Xiaoxu, Jiang, Deying, Wang, Jian, Zhang, Zhaoxuan, Wang, Ruihua, Chen, Chen and Han, Yanshuo (2024). Elucidating thoracic aortic dissection pathogenesis: The interplay of m1A-related gene expressions and miR-16-5p/YTHDC1 Axis in NLRP3-dependent pyroptosis. International Journal of Biological Macromolecules, 274 (Part 2) 133293, 133293. doi: 10.1016/j.ijbiomac.2024.133293
Liu, Fang, Zhang, Ruiyuan, Shen, Caijia, Fu, Xinyi, Song, Yao, Lei, Yichen, Pang, Huiwen, Liu, Yang, Chen, Chen and Li, Jie (2024). Mechanism of Houpo Sanwu Decoction on preventing and treating acute gastric ulcer in rats based on stomach-brain correlation 基于胃脑相关探讨厚朴三物汤防治急性胃溃疡大鼠的作用机制. Chinese Traditional and Herbal Drugs, 55 (16), 5525-5540. doi: 10.7501/j.issn.0253-2670.2024.16.015
Wang, Weihao, Qiao, Jingtao, Zhang, Lina, Zhang, Jie, Luo, Jingyi, Chen, Chen, Wang, Xiaoxia, Jia, Peng, Zhang, Jia, Pan, Qi and Guo, Lixin (2024). Prevalence of very high cardiovascular disease risk in patients with type 2 diabetes mellitus: A population‐based cross‐sectional screening study. Diabetes, Obesity and Metabolism, 26 (10), 4251-4260. doi: 10.1111/dom.15763
Wu, Wei, Yi, Lisha, Zhang, Kai, Chen, Zipei, Shi, Caiping, Chen, Chen, Cai, Yilu, Hu, Lidan and Chen, Xiangjun (2024). Health-related quality of life measurements in children and adolescents with refractive errors: a scoping review. Advances in Ophthalmology Practice and Research, 4 (2), 84-94. doi: 10.1016/j.aopr.2024.03.001
Qiu, Sheng, Wu, Qinan, Wang, Hao, Liu, Dongfang, Chen, Chen, Zhu, Zhiming, Zheng, Hongting, Yang, Gangyi, Li, Ling and Yang, Mengliu (2024). AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation. Nature Communications, 15 (1) 3377, 1-18. doi: 10.1038/s41467-024-47684-9
Bai, Xufeng, Wang, Shuwen, Shu, Limei, Cao, Qingyu, Hu, Huiming, Zhu, Yanchen and Chen, Chen (2024). Hawthorn leaf flavonoids alleviate the deterioration of atherosclerosis by inhibiting SCAP-SREBP2-LDLR pathway through sPLA2-ⅡA signaling in macrophages in mice. Journal of Ethnopharmacology, 327 118006, 118006. doi: 10.1016/j.jep.2024.118006
Yang, Jianmei and Chen, Chen (2024). Hormonal changes in PCOS. Journal of Endocrinology, 261 (1) 230342. doi: 10.1530/joe-23-0342
Geng, Nan, Dong, Siyuan, Xie, Pengpeng, Zhang, Yi, Shi, Rong, Chen, Chen, Xu, Zhao and Chen, Qun (2024). Excessive fluoride induces ovarian function impairment by regulating levels of ferroptosis in fluorosis women and ovarian granulosa cells. Reproductive Toxicology, 125 108556, 108556. doi: 10.1016/j.reprotox.2024.108556
Zhang, Wenyi, Yao, Jing, Chen, Chen, Wang, Jianming and Zhou, Aiyi (2024). Fetuin-B overexpression promotes inflammation in diabetic retinopathy through activating microglia and the NF-κB signaling pathway. Current Eye Research, 49 (2), 168-179. doi: 10.1080/02713683.2023.2276683
Pang, Huiwen, Wu, Youzhi, Chen, Yang, Chen, Chen, Nie, Xuqiang, Li, Peng, Huang, Guojun, Xu, Zhi Ping and Han, Felicity Y. (2024). Development of polysaccharide-coated layered double hydroxide nanocomposites for enhanced oral insulin delivery. Drug Delivery and Translational Research, 14 (9), 2345-2355. doi: 10.1007/s13346-023-01504-7
Xue, Yanan, Wei, Yue, Cao, Lan, Shi, Min, Sheng, Junqing, Xiao, Qin, Cheng, Ziwen, Luo, Tao, Jiao, Quanhui, Wu, Ailan, Chen, Chen, Zhong, Lingyun and Zhang, Changhua (2024). Protective effects of scutellaria-coptis herb couple against non-alcoholic steatohepatitis via activating NRF2 and FXR pathways in vivo and in vitro. Journal of Ethnopharmacology, 318 (Pt A) 116933, 1-18. doi: 10.1016/j.jep.2023.116933
Liu, Chang, Ding, Xuying, Xie, Yining, Chen, Chen, Zhao, Meijun, Duan, Yanming, Yuan, Guojing and Ren, Junxi (2024). Isolation and purification of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu peptides and study of their antioxidant effects and mechanisms. Frontiers in Pharmacology, 15 1353871. doi: 10.3389/fphar.2024.1353871
Li, Jiaxi, Li, Mei, Ke, Hao, Han, Yang, Huang, Yanhong, Zhou, Yan, Luo, Ziqiang, Chen, Chen and Feng, Dandan (2024). LEAP2 ameliorates high fat diet-impaired glucose tolerance and enhances glucose-stimulated insulin secretion from β cells through PPARγ signal pathway. Chinese Medical Journal, 137 (18), 2266-2268. doi: 10.1097/CM9.0000000000003215
Song, Yueqin, Chen, Chen and Li, Wei (2024). Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms. Chinese Herbal Medicines. doi: 10.1016/j.chmed.2024.09.006
He, Yirui, Zhang, Cheng, Wu, Shaobo, Li, Ke, Zhang, Siliang, Tian, Mingyuan, Chen, Chen, Liu, Dongfang, Yang, Gangyi, Li, Ling and Yang, Mengliu (2024). Central NUCB2/nesfatin-1 signaling ameliorates liver steatosis through suppression of endoplasmic reticulum stress in the hypothalamus: Central nesfatin-1 ameliorates hepatosteatosis. Metabolism: Clinical and Experimental 156046, 156046. doi: 10.1016/j.metabol.2024.156046
Yang, Shan, Li, Yang, Tian, Mingyuan, Deng, Wuquan, Liu, Dongfang, Chen, Chen, Zhu, Zhiming, Zheng, Hongting, Yang, Gangyi, Li, Ling and Yang, Mengliu (2024). Hypothalamic P62 (SQSTM1) regulates energy balance by modulating leptin signaling. Theranostics , 14 (17), 6605-6624. doi: 10.7150/thno.96480
Li, Lin, Zhang, Ruiyuan, Hu, Yichen, Deng, Hongdan, Pei, Xu, Liu, Fang and Chen, Chen (2023). Impact of Oat (Avena sativa L.) on metabolic syndrome and potential physiological mechanisms of action: a current review. Journal of Agricultural and Food Chemistry, 71 (41), 14838-14852. doi: 10.1021/acs.jafc.3c02304
Du, Ming-Fei, Zhang, Xi, Hu, Gui-Lin, Mu, Jian-Jun, Chu, Chao, Liao, Yue-Yuan, Chen, Chen, Wang, Dan, Ma, Qiong, Yan, Yu, Jia, Hao, Wang, Ke-Ke, Sun, Yue, Niu, Ze-Jiaxin, Man, Zi-Yue, Wang, Lan, Zhang, Xiao-Yu, Luo, Wen-Jing, Gao, Wei-Hua, Li, Hao, Wu, Guan-Ji, Gao, Ke, Zhang, Jie and Wang, Yang (2023). Associations of lipid accumulation product, visceral adiposity index, and triglyceride-glucose index with subclinical organ damage in healthy Chinese adults. Frontiers in Endocrinology, 14 1164592. doi: 10.3389/fendo.2023.1164592
Xu, Yangting, Chen, Chen, Ji, Ming, Xiang, Yang, Han, Yang, Feng, Dandan and Luo, Ziqiang (2023). An online flipped classroom approach improves the physiology score and subsequent course scores of the top-performing students. Advances in Physiology Education, 47 (3), 538-547. doi: 10.1152/advan.00060.2022
Zhang, Wanlong, Zhang, Changhua, Cao, Lan, Liang, Fang, Xie, Weihua, Tao, Liang, Chen, Chen, Yang, Ming and Zhong, Lingyun (2023). Application of digital-intelligence technology in the processing of Chinese materia medica. Frontiers in Pharmacology, 14 1208055, 1-12. doi: 10.3389/fphar.2023.1208055
Li, Hongzhuo, Gu, Wenyi, Jeffery, Penny and Chen, Chen (2023). 17‐β‐estradiol reduces surface PD‐L1 expression in estrogen receptor‐positive breast cancer but not type 1 endometrial cancer cells. Clinical and Translational Medicine, 13 (7) e1330, e1330. doi: 10.1002/ctm2.1330
Yang, Jianmei, Wang, Enli, Chen, Wenbin, Xu, Baihui, Chen, Chen, Zhang, Guimin and Yao, Jingchun (2023). TMT-based proteomics analysis of the intervention effect of orlistat on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet. ACS Omega, 8 (28), 24831-24840. doi: 10.1021/acsomega.3c00578
Zhang, Jing-Tian, Xie, Li-Ya, Shen, Qiong, Liu, Wei, Li, Ming-Han, Hu, Rui-Yi, Hu, Jun-Nan, Wang, Zi, Chen, Chen and Li, Wei (2023). Platycodin D stimulates AMPK activity to inhibit the neurodegeneration caused by reactive oxygen species-induced inflammation and apoptosis. Journal of Ethnopharmacology, 308 116294, 1-13. doi: 10.1016/j.jep.2023.116294
Chen, Chen and Smith, Maree T. (2023). The NLRP3 inflammasome: role in the pathobiology of chronic pain. Inflammopharmacology, 31 (4), 1589-1603. doi: 10.1007/s10787-023-01235-8
Zhang, Yue, Xian, He, Strounina, Ekaterina, Gunther, Kimberley S., Sweet, Matthew J., Chen, Chen, Yu, Chengzhong and Wang, Yue (2023). Mesoporous Organosilica Nanoparticles with Tetrasulphide Bond to Enhance Plasmid DNA Delivery. Pharmaceutics, 15 (3) 1013, 1-11. doi: 10.3390/pharmaceutics15031013
Li, Wenrong, Dong, Siyuan, Chen, Qun, Chen, Chen and Dong, Zhaoheng (2023). Corrigendum to “Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis” [Eur. J. Pharmacol. 878 (2020) 173098]. European Journal of Pharmacology, 943 175563, 175563. doi: 10.1016/j.ejphar.2023.175563
Zhou, Xin, Wang, Yanping, Chen, Wenyun, Zhang, Hongmin, He, Yirui, Dai, Han, Hu, Wenjing, Li, Ke, Zhang, Lili, Chen, Chen, Yang, Gangyi and Li, Ling (2023). Circulating HHIP levels in women with insulin resistance and PCOS: Effects of physical activity, cold stimulation and anti-diabetic drug therapy. Journal of Clinical Medicine, 12 (3) 888, 1-17. doi: 10.3390/jcm12030888
Pang, Huiwen, Huang, Xiangquan, Xu, Zhi Ping, Chen, Chen and Han, Felicity Y. (2023). Progress in oral insulin delivery by PLGA nanoparticles for the management of diabetes. Drug Discovery Today, 28 (1) 103393, 1-11. doi: 10.1016/j.drudis.2022.103393
Chen, Qun, Kao, Xibin, Gao, Yan, Chen, Jinghong, Dong, Zhaoheng and Chen, Chen (2023). Correction to: Nitric oxide-caused rabbit chondrocyte apoptosis is linked to cytoskeletal protein proteolysis anomaly through intracellular JNK and ERK signal pathways (Molecular & Cellular Toxicology, (2023), 19, 1, (71-79), 10.1007/s13273-022-00241-1). Molecular and Cellular Toxicology, 19 (1), 219-220. doi: 10.1007/s13273-022-00282-6
Wang, Hui, Li, Zhengzheng, Liu, Yinan, Zhang, Meng, Shi, Yawen, Zhang, Ying, Mi, Ge, Wang, Mengying, He, Ying, Chen, Yonghui, Chen, Chen and Chen, Jinghong (2023). Effects of Selenoprotein S knockdown on endoplasmic reticulum stress in ATDC5 cells and gene expression profiles in hypertrophic chondrocytes. Biological Trace Element Research, 201 (4), 1965-1976. doi: 10.1007/s12011-022-03313-4
Ran, Li-Sha, Wu, Ya-Zeng, Gan, Yi-Wen, Wang, Hong-Lian, Wu, Li-Juan, Zheng, Chun-Mei, Ming, Yao, Xiong, Ran, Li, Yong-Lin, Lei, Shi-Hang, Wang, Xue, Lao, Xiao-Qing, Zhang, Hong-Min, Wang, Li, Chen, Chen and Zhao, Chang-Ying (2023). Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease. Journal of Natural Medicines, 77 (1), 73-86. doi: 10.1007/s11418-022-01647-w
Han, Yanshuo, Chen, Chen and Zhang, Jian (2023). Editorial: Epigenetic mechanisms and epigenetic-based therapies in cardiometabolic and vascular disease. Frontiers in Genetics, 14 1233096, 1233096. doi: 10.3389/fgene.2023.1233096
Du, Chenping, Whiddett, Rani O., Buckle, Irina, Chen, Chen, Forbes, Josephine M. and Fotheringham, Amelia K. (2022). Advanced glycation end products and inflammation in type 1 diabetes development. Cells, 11 (21) 3503, 1-18. doi: 10.3390/cells11213503
Frankel, Adam, Thomson, Iain, Shah, Ayesha, Chen, Chen, Zahir, Syeda Farah, Barbour, Andrew, Holtmann, Gerald and Mark Smithers, B (2022). Laparoscopic fundoplication versus laparoscopic Roux-en-Y gastric bypass for gastro-oesophageal reflux disease in obese patients: protocol for a randomized clinical trial. BJS Open, 6 (6) zrac132. doi: 10.1093/bjsopen/zrac132
Chen, Xiaolin, Huang, Lili, Cui, Ling, Xiao, Zhuoni, Xiong, Xiaoxing and Chen, Chen (2022). Sodium–glucose cotransporter 2 inhibitor ameliorates high fat diet-induced hypothalamic–pituitary–ovarian axis disorders. The Journal of Physiology, 600 (21), 4549-4568. doi: 10.1113/jp283259
Cui, Ling, Tan, Chunlu, Huang, Lili, Wang, Weihao, Huang, Zhengxiang, Geng, Fang, Wu, Mengjun, Chen, Xiaolin, Cowley, Michael, Roelfsema, Ferdinand and Chen, Chen (2022). Dapagliflozin partially restores reproductive function in MC4R KO obese female mice. Journal of Endocrinology, 254 (2), 65-76. doi: 10.1530/joe-21-0449
Zhang, Yanjun, Bai, Guangdong, Li, Xue, Nepal, Surya, Grobler, Marthie, Chen, Chen and Ko, Ryan K. L. (2022). Preserving privacy for distributed genome-wide analysis against identity tracing attacks. IEEE Transactions on Dependable and Secure Computing, 20 (4), 1-17. doi: 10.1109/tdsc.2022.3186672
Xing, JingJing and Chen, Chen (2022). Hyperinsulinemia: beneficial or harmful or both on glucose homeostasis. American Journal of Physiology-Endocrinology and Metabolism, 323 (1), E2-E7. doi: 10.1152/ajpendo.00441.2021
Huang, Zhengxiang, Xiao, Lan, Xiao, Yin and Chen, Chen (2022). The modulatory role of growth hormone in inflammation and macrophage activation. Endocrinology, 163 (8) bqac088, 1-12. doi: 10.1210/endocr/bqac088
Xiang, Ting, Zhang, Siliang, Li, Qinge, Li, Ling, Liu, Hua, Chen, Chen, Yang, Gangyi and Yang, Mengliu (2022). GPHB5 is a biomarker in women with metabolic syndrome: results from cross-sectional and intervention studies. Frontiers in Endocrinology, 13 893142, 1-12. doi: 10.3389/fendo.2022.893142
Dong, Siyuan, Yang, Yanni, He, Biqi, Xu, Zhao, Zhou, Zhaoqiang, Wang, Jinhai, Chen, Chen and Chen, Qun (2022). Effect of sodium fluoride on reproductive function through regulating reproductive hormone level and circulating SIRT1 in female rats. Biological Trace Element Research, 201 (4), 1-12. doi: 10.1007/s12011-022-03283-7
Wu, Yihao, Jiang, Deying, Zhang, Hao, Yin, Fanxing, Guo, Panpan, Zhang, Xiaoxu, Bian, Ce, Chen, Chen, Li, Shuixin, Yin, Yuhan, Böckler, Dittmar, Zhang, Jian and Han, Yanshuo (2022). N1-methyladenosine (m1A) regulation associated with the pathogenesis of abdominal aortic aneurysm through YTHDF3 modulating macrophage polarization. Frontiers in Cardiovascular Medicine, 9 883155, 1-22. doi: 10.3389/fcvm.2022.883155
Chen, Qun, Kao, Xibin, Gao, Yan, Chen, Jinghong, Dong, Zhaoheng and Chen, Chen (2022). Nitric oxide-caused rabbit chondrocyte apoptosis is linked to cytoskeletal protein proteolysis anomaly through intracellular JNK and ERK signal pathways. Molecular and Cellular Toxicology, 19 (1), 1-2. doi: 10.1007/s13273-022-00241-1
Qiu, Sheng, Liang, Zerong, Wu, Qinan, Wang, Miao, Yang, Mengliu, Chen, Chen, Zheng, Hongting, Zhu, Zhiming, Li, Ling and Yang, Gangyi (2022). Hepatic lipid accumulation induced by a high-fat diet is regulated by Nrf2 through multiple pathways. The FASEB Journal, 36 (5) e22280, e22280. doi: 10.1096/fj.202101456R
Li, Jiaxi, Huang, Pu, Xiong, Jing, Liang, Xinyue, Li, Mei, Ke, Hao, Chen, Chunli, Han, Yang, Huang, Yanhong, Zhou, Yan, Luo, Ziqiang, Feng, Dandan and Chen, Chen (2022). Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids. Endocrine Connections, 11 (5) e220012, 1-9. doi: 10.1530/ec-22-0012
Xing, Jing-Jing, Mi, Xiao-Jie, Hou, Jin-Gang, Cai, En-Bo, Zheng, Si-Wen, Wang, Shi-Han, Wang, Zi, Chen, Chen and Li, Wei (2022). Maltol mitigates cisplatin-evoked cardiotoxicity via inhibiting the PI3K/Akt signaling pathway in rodents in vivo and in vitro. Phytotherapy Research, 36 (4), 1724-1735. doi: 10.1002/ptr.7405
Zhao, Anjiang, Li, Dan, Mao, Xiongmin, Yang, Mengliu, Deng, Wuquan, Hu, Wenjing, Chen, Chen, Yang, Gangyi and Li, Ling (2022). GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling. Cell Death and Disease, 13 (3) 260, 260. doi: 10.1038/s41419-022-04690-3
Li, Kejia, Liang, Zerong, Xu, Weiwei, Dai, Han, Tian, Mingyuan, Li, Ling, Liu, Hua, Chen, Chen, Liu, Dongfang, Zheng, Hongting, Zhu, Zhiming, Yang, Gangyi and Yang, Mengliu (2022). CTRP7 is a biomarker related to insulin resistance and oxidative stress: cross-sectional and intervention studies in vivo and in vitro. Oxidative Medicine and Cellular Longevity, 2022 6877609, 1-17. doi: 10.1155/2022/6877609
Yin, Fanxing, Zhang, Hao, Guo, Panpan, Wu, Yihao, Zhao, Xinya, Li, Fangjun, Bian, Ce, Chen, Chen, Han, Yanshuo and Liu, Kun (2022). Comprehensive analysis of key m6A modification related genes and immune infiltrates in human aortic dissection. Frontiers in Cardiovascular Medicine, 9 831561, 831561. doi: 10.3389/fcvm.2022.831561
Chen, Chen, Li, Wenzhi, Yin, Mingru, Li, Menghui, Wu, Ling, Si, Jiqiang, Zhao, Leiwen, Li, Bin, Yan, Zheng and Lyu, Qifeng (2022). Does the cell number of 0PN embryos on day 3 affect pregnancy and neonatal outcomes following single blastocyst transfer?. BMC Pregnancy and Childbirth, 22 (1) 200, 1-9. doi: 10.1186/s12884-022-04492-7
Xu, Yangting, Chen, Chen, Feng, Dandan and Luo, Ziqiang (2022). A survey of college students on the preference for online teaching videos of variable durations in online flipped classroom. Frontiers in Public Health, 10 838106, 838106. doi: 10.3389/fpubh.2022.838106
Chen, Xiaolin, Xiao, Zhuoni, Cai, Yuli, Huang, Lili and Chen, Chen (2022). Hypothalamic mechanisms of obesity-associated disturbance of hypothalamic–pituitary–ovarian axis. Trends in Endocrinology and Metabolism, 33 (3), 206-217. doi: 10.1016/j.tem.2021.12.004
Tong, Yue, Xu, Sai, Huang, Lili and Chen, Chen (2022). Obesity and insulin resistance: Pathophysiology and treatment. Drug Discovery Today, 27 (3), 822-830. doi: 10.1016/j.drudis.2021.11.001
Qiu, Jiaxin, Du, Tong, Chen, Chen, Lyu, Qifeng, Mol, Ben W., Zhao, Ming and Kuang, Yanping (2022). Impact of uterine malformations on pregnancy and neonatal outcomes of IVF/ICSI-frozen embryo transfer. Human Reproduction, 37 (3), 428-446. doi: 10.1093/humrep/deac003
Chen, Chen, Yu, Sha, Yu, Weina, Yan, Zhiguang, Jin, Wei, Si, Jiqiang, Li, Menghui, Cai, Renfei, Li, Dongying, Wang, Li, Chen, Qiuju, Kuang, Yanping, Lyu, Qifeng and Long, Hui (2022). Luteinizing hormone suppression by progestin-primed ovarian stimulation is associated with higher implantation rate for patients with polycystic ovary syndrome who underwent in vitro fertilization/intracytoplasmic sperm injection cycles: comparing with short protocol. Frontiers in Physiology, 12 744968. doi: 10.3389/fphys.2021.744968
Wang, Haohao, Yu, Wenliu, Zhang, Danfeng, Zhao, Yan, Chen, Chen, Zhu, Hongyan, Cai, Enbo and Yan, Zhaowei (2022). Cytotoxic and anti-tumor effects of 3,4-seco-lupane triterpenoids from the leaves of Eleutherococcus sessiliflorus against hepatocellular carcinoma. Natural Product Research, 36 (4), 1062-1066. doi: 10.1080/14786419.2020.1844698
Zhao, Miao-Miao, Lu, Jing, Li, Sen, Wang, Hao, Cao, Xi, Li, Qi, Shi, Ting-Ting, Matsunaga, Kohichi, Chen, Chen, Huang, Haixia, Izumi, Tetsuro and Yang, Jin-Kui (2021). Author Correction: Berberine is an insulin secretagogue targeting the KCNH6 potassium channel (Nature Communications, (2021), 12, 1, (5616), 10.1038/s41467-021-25952-2). Nature Communications, 12 (1) 6342, 6342. doi: 10.1038/s41467-021-26635-8
Zhang, Hao, Bian, Ce, Tu, Simei, Yin, Fanxing, Guo, Panpan, Zhang, Jian, Song, Xiaotong, Liu, Qingyang, Chen, Chen and Han, Yanshuo (2021). Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in human aortic dissection. BMC Genomics, 22 (1) 724, 1-13. doi: 10.1186/s12864-021-08012-3
Hu, Wenjing, Zhan, Bin, Li, Qinge, Yang, Gangyi, Yang, Mengliu, Tan, Minghong, Geng, Shan, Liu, Hua, Chen, Chen, Liu, Dongfang and Li, Ling (2021). Circulating CTRP7 is a potential predictor for metabolic syndrome. Frontiers in Endocrinology, 12 774309, 774309. doi: 10.3389/fendo.2021.774309
Chen, Qun, Li, Zhen, Xu, Zhao, Chen, Chen, Wang, Jiawei, Zhu, Jinyuan and Dong, Zhaoheng (2021). miR-378d is involved in the regulation of apoptosis and autophagy of and E2 secretion from cultured ovarian granular cells treated by sodium fluoride. Biological Trace Element Research, 199 (11), 4119-4128. doi: 10.1007/s12011-020-02524-x
He, Biqi, Dong, Siyuan, Chen, Qun, Dong, Zhaoheng and Chen, Chen (2021). DNA methylation profiles of ovarian granular cells from fluorosis female patients suffering reproductive dysfunctions. Biological Trace Element Research, 200 (8), 3529-3536. doi: 10.1007/s12011-021-02954-1
Chen, Qun, Kao, Xibin, Gao, Yan, Chen, Jinghong, Dong, Zhaoheng and Chen, Chen (2021). Increase in NO causes osteoarthritis and chondrocyte apoptosis and chondrocyte ERK plays a protective role in the process. Molecular Biology Reports, 48 (11), 7303-7312. doi: 10.1007/s11033-021-06731-0
Xue, Shiyao, Han, Hongdong, Rui, Shunli, Yang, Mengliu, Huang, Yizhou, Zhan, Bin, Geng, Shan, Liu, Hua, Chen, Chen, Yang, Gangyi and Li, Ling (2021). Serum fetuin-B levels are elevated in women with metabolic syndrome and associated with increased oxidative stress. Oxidative Medicine and Cellular Longevity, 2021 (1) 6657658, 1-17. doi: 10.1155/2021/6657658
Zhao, Miao-Miao, Lu, Jing, Li, Sen, Wang, Hao, Cao, Xi, Li, Qi, Shi, Ting-Ting, Matsunaga, Kohichi, Chen, Chen, Huang, Haixia, Izumi, Testuro and Yang, Jin-Kui (2021). Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Nature Communications, 12 (1) 5616, 5616. doi: 10.1038/s41467-021-25952-2
Mazzone, Stuart B., Yang, Seung-Kwon, Keller, Jennifer A., Simanauskaite, Juste, Arikkatt, Jaisy, Fogarty, Matthew J., Moe, Aung Aung Kywe, Chen, Chen, Trewella, Matthew W., Tian, Luyi, Ritchie, Matthew E., Chua, Brendan Y., Phipps, Simon, Short, Kirsty R. and McGovern, Alice E. (2021). Modulation of vagal sensory neurons via high mobility group box-1 and receptor for advanced glycation end products: implications for respiratory viral infections. Frontiers in Physiology, 12 744812, 744812. doi: 10.3389/fphys.2021.744812
Wang, Weihao, Duan, Xiaoye, Huang, Zhengxiang, Pan, Qi, Chen, Chen and Guo, Lixin (2021). The GH-IGF-1 axis in circadian rhythm. Frontiers in Molecular Neuroscience, 14 742294, 742294. doi: 10.3389/fnmol.2021.742294
Lu, Xuehan, Huang, Lili, Huang, Zhengxiang, Feng, Dandan, Clark, Richard J. and Chen, Chen (2021). LEAP-2: an emerging endogenous ghrelin receptor antagonist in the pathophysiology of obesity. Frontiers in Endocrinology, 12 717544, 717544. doi: 10.3389/fendo.2021.717544
Xia, Xuyun, Xue, Shiyao, Yang, Gangyi, Li, Yu, Liu, Hua, Chen, Chen and Li, Ling (2021). Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide. PeerJ, 9 e11869, 1-16. doi: 10.7717/peerj.11869
Huang, Zhengxiang, Lu, Xuehan, Huang, Lili, Chen, Yang, Zhang, Chunhong, Veldhuis, Johannes D. and Chen, Chen (2021). Suppression of hyperinsulinemia restores growth hormone secretion and metabolism in obese mice. Journal of Endocrinology, 250 (3), 105-116. doi: 10.1530/JOE-20-0616
Wang, Weihao, Huang, Zhengxiang, Huang, Lili, Tan, Chunlu, Chen, Wanlin, Roelfsema, Ferdinand, Chen, Chen and Guo, Lixin (2021). Rotating day and night disturb growth hormone secretion profiles, body energy metabolism and insulin levels in mice. Neuroendocrinology, 112 (5), 1-12. doi: 10.1159/000518338
Sinha, Roma, Ngo, Minh Dao, Bartlett, Stacey, Bielefeldt-Ohmann, Helle, Keshvari, Sahar, Hasnain, Sumaira Z., Donovan, Meg L., Kling, Jessica C., Blumenthal, Antje, Chen, Chen, Short, Kirsty R. and Ronacher, Katharina (2021). Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective. Frontiers in Cellular and Infection Microbiology, 11 691823, 691823. doi: 10.3389/fcimb.2021.691823
Han, Yanshuo, Zhang, Hao, Bian, Ce, Chen, Chen, Tu, Simei, Guo, Jiahui, Wu, Yihao, Böckler, Dittmar and Zhang, Jian (2021). Circular RNA expression: its potential regulation and function in abdominal aortic aneurysms. Oxidative Medicine and Cellular Longevity, 2021 (1) 9934951, 1-21. doi: 10.1155/2021/9934951
Keshvari, Sahar, Caruso, Melanie, Teakle, Ngari, Batoon, Lena, Sehgal, Anuj, Patkar, Omkar L., Ferrari-Cestari, Michelle, Snell, Cameron E., Chen, Chen, Stevenson, Alex, Davis, Felicity M., Bush, Stephen J., Pridans, Clare, Summers, Kim M., Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2021). CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genetics, 17 (6) e1009605, e1009605. doi: 10.1371/journal.pgen.1009605
Zheng, Xiao-Min, Yang, Fang-Yuan, Chen, Xing, Yang, Yan-Hui, Zhu, Xiao-Rong, Chen, Chen and Yang, Jin-Kui (2021). Development of a sensitive and reliable ELISA kit of urinary haptoglobin to predict progress of diabetic kidney disease. Diabetes/Metabolism Research and Reviews, 37 (4) e3432, 1-9. doi: 10.1002/dmrr.3432
Janda, Monika, Robledo, Kristy P., Gebski, Val, Armes, Jane E., Alizart, Michelle, Brennan, Donal, Cummings, Margaret, Chen, Chen, Leung, Yee, Sykes, Peter, McNally, Orla, Oehler, Martin K., Walker, Graeme, Garrett, Andrea, Tang, Amy, Land, Russell, Nicklin, James L., Chetty, Naven, Perrin, Lewis C., Hoet, Greet, Sowden, Katherine, Eva, Lois, Tristram, Amanda and Obermair, Andreas (2021). Complete pathological response following levonorgestrel intrauterine device in clinically stage 1 endometrial adenocarcinoma: results of a randomized clinical trial. Gynecologic Oncology, 161 (1), 143-151. doi: 10.1016/j.ygyno.2021.01.029
Zhao, Yan, Wang, Xu, Chen, Chen, Shi, Kun, Li, Jianming and Du, Rui (2021). Protective effects of 3,4-Seco-lupane triterpenes from food raw materials of the leaves of Eleutherococcus senticosus and Eleutherococcus sessiliflorus on arrhythmia induced by barium chloride. Chemistry and Biodiversity, 18 (4) e2001021, 1-10. doi: 10.1002/cbdv.202001021
Wang, Weihao, Huang, Zhengxiang, Huang, Lili, Gao, Lyn, Cui, Ling, Cowley, Michael, Guo, Lixin and Chen, Chen (2021). Time-restricted feeding restored insulin-growth hormone balance and improved substrate and energy metabolism in MC4RKO obese mice. Neuroendocrinology, 112 (2), 174-185. doi: 10.1159/000515960
Zhang, Chang-Hua, Sheng, Jun-Qing, Xie, Wei-Hua, Luo, Xiao-Quan, Xue, Ya-Nan, Xu, Guo-Liang and Chen, Chen (2021). Mechanism and basis of Traditional Chinese Medicine against obesity: prevention and treatment strategies. Frontiers in Pharmacology, 12 615895, 1-12. doi: 10.3389/fphar.2021.615895
Cui, Ling, Lin, Yonghong, Wang, Fang and Chen, Chen (2021). Effectiveness of progesterone-primed ovarian stimulation in assisted reproductive technology: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics, 303 (3), 615-630. doi: 10.1007/s00404-020-05939-y
Huang, Zhengxiang, Lu, Xuehan, Huang, Lili, Zhang, Chunhong, Veldhuis, Johannes D., Cowley, Michael A. and Chen, Chen (2021). Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice. The FASEB Journal, 35 (1) e21269, e21269. doi: 10.1096/fj.202001924rr
Huang, Lili, Gao, Lin and Chen, Chen (2021). Role of medium-chain fatty acids in healthy metabolism: a clinical perspective. Trends in Endocrinology and Metabolism, 32 (6), 351-366. doi: 10.1016/j.tem.2021.03.002
Ling, Dan, Wan, Rong, Chen, Qun, Liu, Xinyuan, Qi, Xueli, Chen, Chen, Shi, Xiaoman and Dong, Zhaoheng (2021). Assessment of chronic disease management mode (CDMM) on participants with primary hypertension. Tropical Medicine and International Health, 26 (7), 829-837. doi: 10.1111/tmi.13577
Janda, Monika, Robledo, Kristy P., Gebski, Val, Armes, Jane E., Alizart, Michelle, Brennan, Donal, Cummings, Margaret, Chen, Chen, Leung, Yee, Sykes, Peter, McNally, Orla, Oehler, Martin K., GraemeWalker, , Garrett, Andrea, Tang, Amy, Land, Russell, Nicklin, James L., Chetty, Naven, Perrin, Lewis C., Hoet, Greet, Sowden, Katherine, Eva, Lois, Tristram, Amanda and Obermair, Andreas (2021). Corrigendum to “Complete pathological response following levonorgestrel intrauterine device in clinically stage 1 endometrial adenocarcinoma: Results of a randomized clinical trial” [Gynecologic Oncology 161 (2021) 143–151](S0090825821000895)(10.1016/j.ygyno.2021.01.029). Gynecologic Oncology, 162 (2), 526-526. doi: 10.1016/j.ygyno.2021.05.016
Su, Wen-Ya, Li, Ying, Chen, Xuan, Li, Xin, Wei, Heng, Liu, Zhi, Shen, Qiong, Chen, Chen, Wang, Ying-Ping and Li, Wei (2021). Ginsenoside Rh1 improves type 2 diabetic nephropathy through AMPK/PI3K/Akt-mediated inflammation and apoptosis signaling pathway. American Journal of Chinese Medicine, 49 (5), 1215-1233. doi: 10.1142/S0192415X21500580
Zhang, Danfeng, Chen, Chen, Zhao, Yan, Gao, Yugang, Cai, Enbo and Zhu, Hongyan (2021). 3,4-seco-lupane triterpene derivatives with cytotoxic activities from the leaves of Eleutherococcus sessiliflorus. Natural Product Research, 35 (16), 2633-2639. doi: 10.1080/14786419.2019.1656622
Wang, Haohao, Chen, Chen, Liu, Ruijuan, Wang, Xu, Zhao, Yan, Yan, Zhaowei, Cai, Enbo and Zhu, Hongyan (2021). Potential myocardial protection of 3,4-seco-lupane triterpenoids from Acanthopanax sessiliflorus leaves. Chemistry and Biodiversity, 18 (1) e2000830, 1-11. doi: 10.1002/cbdv.202000830
Su, Yinxia, Lu, Yaoqin, Li, Wenli, Xue, Mingyue, Chen, Chen, Haireti, Muyaseer, Li, Yuanyuan, Liu, Zhenhui, Liu, Yanshi, Wang, Shuxia and Yao, Hua (2020). Prevalence and correlation of metabolic syndrome: a cross-sectional study of nearly 10 million multi-ethnic Chinese adults. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Volume 13, 4869-4883. doi: 10.2147/dmso.s278346
Huang, Zhengxiang, Wang, Weihao, Huang, Lili, Guo, Lixin and Chen, Chen (2020). Suppression of insulin secretion in the treatment of obesity: a systematic review and meta-analysis. Obesity, 28 (11), 2098-2106. doi: 10.1002/oby.22955
Zhao, Yu-Feng, Li, Xiao-Cheng, Liang, Xiang-Yan, Zhao, Yan-Yan, Xie, Rong, Zhang, Li-Jun, Zhang, Xiao-Chun and Chen, Chen (2020). GPR120 regulates pancreatic polypeptide secretion from male mouse islets via PLC-mediated calcium mobilization. Endocrinology, 161 (10) bqaa157. doi: 10.1210/endocr/bqaa157
Chen, Chen, Sun, Tingye, Yin, Mingru, Yan, Zhiguang, Yu, Weina, Long, Hui, Wang, Li, Liao, Xiaoyu, Yan, Zheng, Li, Wenzhi and Lyu, Qifeng (2020). Ionomycin-induced mouse oocyte activation can disrupt preimplantation embryo development through increased reactive oxygen species reaction and DNA damage. Molecular Human Reproduction, 26 (10), 773-783. doi: 10.1093/molehr/gaaa056
Liu, Yang, Dai, Yue, Li, Qing, Chen, Chen, Chen, Hao, Song, Yuanjian, Hua, Fang and Zhang, Zuohui (2020). Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia. Neuroscience Letters, 736 135279, 1-7. doi: 10.1016/j.neulet.2020.135279
Zhang, Chang-hua, Zhou, Bu-gao, Sheng, Jun-qing, Chen, Yang, Cao, Ying-qian and Chen, Chen (2020). Molecular mechanisms of hepatic insulin resistance in nonalcoholic fatty liver disease and potential treatment strategies. Pharmacological Research, 159 104984, 104984. doi: 10.1016/j.phrs.2020.104984
Ma, Tianqi, Cheng, Qingmei, Chen, Chen, Luo, Ziqiang and Feng, Dandan (2020). Excessive activation of NMDA receptors in the pathogenesis of multiple peripheral organs via mitochondrial dysfunction, oxidative stress and inflammation. SN Comprehensive Clinical Medicine, 2 (5), 551-569. doi: 10.1007/2Fs42399-020-00298-w
Liu, Wei, Leng, Jing, Hou, Jin-gang, Jiang, Shuang, Wang, Zi, Liu, Zhi, Gong, Xiao-jie, Chen, Chen, Wang, Ying-ping and Li, Wei (2020). Saponins derived from the stems and leaves of Panax ginseng attenuate scrotal heat-induced spermatogenic damage via inhibiting the MAPK mediated oxidative stress and apoptosis in mice. Phytotherapy Research, 35 (1) ptr.6801, 311-323. doi: 10.1002/ptr.6801
Li, Wenrong, Dong, Siyuan, Chen, Qun, Chen, Chen and Dong, Zhaoheng (2020). Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis. European Journal of Pharmacology, 878 173098, 173098. doi: 10.1016/j.ejphar.2020.173098
Chen, Chen, Zhang, Danfeng, Zhao, Yan, Cai, Enbo, Zhu, Hongyan and Gao, Yugang (2020). A new 3,4-seco-lupane triterpenene glycosyl ester from the leaves of Eleutherococcus sessiliflorus. Natural Product Research, 34 (13), 1927-1930. doi: 10.1080/14786419.2018.1564292
McDonald, H., Peart, J., Kurniawan, N.D., Galloway, G., Royce, S.G., Samuel, C.S. and Chen, C. (2020). Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion. Biomedicine and Pharmacotherapy, 127 110165, 110165. doi: 10.1016/j.biopha.2020.110165
Tu, Jun, Zhu, Shuilan, Li, Bingtao, Xu, Guoliang, Luo, Xinxin, Jiang, Li, Yan, Xiaojun, Zhang, Ruiping and Chen, Chen (2020). Gegen Qinlian Decoction coordinately regulates PPARγ and PPARα to improve glucose and lipid homeostasis in diabetic rats and insulin resistance 3T3-L1 adipocytes. Frontiers in Pharmacology, 11 811, 811. doi: 10.3389/fphar.2020.00811
Zhang, Chang-hua, Xiao, Qin, Sheng, Jun-qing, Liu, Tong-tong, Cao, Ying-qian, Xue, Ya-nan, Shi, Min, cao, Zheng, Zhou, Li-fen, Luo, Xiao-quan, Deng, Ke-zhong and Chen, Chen (2020). Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways. Biomedicine and Pharmacotherapy, 126 110076, 110076. doi: 10.1016/j.biopha.2020.110076
Liu, Xiangxiang, Mi, Xiaojie, Wang, Zi, Zhang, Ming, Hou, Jingang, Jiang, Shuang, Wang, Yingping, Chen, Chen and Li, Wei (2020). Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway. Cell Death and Disease, 11 (6) 454, 1-15. doi: 10.1038/s41419-020-2597-7
Huang, Zhengxiang, Huang, Lili, Waters, Michael J. and Chen, Chen (2020). Insulin and growth hormone balance: implications for obesity. Trends in Endocrinology and Metabolism, 31 (9), 642-654. doi: 10.1016/j.tem.2020.04.005
Kaur, Harleen, Muhlhausler, Beverly S., Sim, Pamela Su-Lin, Page, Amanda J., Li, Hui, Nunez-Salces, Maria, Clarke, Georgia S., Huang, Lili, Wilson, Rebecca L., Veldhuis, Johannes D., Chen, Chen, Roberts, Claire T. and Gatford, Kathryn L. (2020). Pregnancy, but not dietary octanoic acid supplementation, stimulates the ghrelin-pituitary growth hormone axis in mice. Journal of Endocrinology, 245 (2), 327-342. doi: 10.1530/JOE-20-0072
Dong, Zhaoheng, Fan, Ping, Chen, Qun and Chen, Chen (2020). Facile conversion of cis into trans oxane as liquid crystals. Scientific Reports, 10 (1) 6936, 6936. doi: 10.1038/s41598-020-63902-y
Su, Weiwei, Chen, Chen, Wang, Tao, Li, Xiao, Liu, Yanyan, Wang, Han, Zhao, Shuai, Zuo, Changjing, Sun, Gaofeng and Bu, Wenbo (2020). Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy. Materials Horizons, 7 (4), 1115-1125. doi: 10.1039/c9mh01725a
Aad, G., Abbott, B., Abbott, D. C., Abud, A. Abed, Abeling, K., Abhayasinghe, D. K., Abidi, S. H., AbouZeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Achkar, B., Adachi, S., Adam, L., Bourdarios, C. Adam, Adamczyk, L., Adamek, L., Adelman, J., Adersberger, M., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A. ... Zwalinski, L. (2020). Combination of searches for Higgs boson pairs in pp collisions at √s=13 TeV with the ATLAS detector. Physics Letters B, 800 ARTN 135103. doi: 10.1016/j.physletb.2019.135103
Wu, Lijuan, Li, Fei, Zhao, Changying, Ming, Yao, Zheng, Chunmei, Li, Yonglin, Lei, Shihang and Chen, Chen (2020). Effects and mechanisms of traditional Chinese herbal medicine in the treatment of ischemic cardiomyopathy. Pharmacological Research, 151 104488, 104488. doi: 10.1016/j.phrs.2019.104488
Huang, Zhengxiang, Huang, Lili, Wang, Chengjian, Zhu, Shanli, Qi, Xinzhou, Chen, Yang, Zhang, Yanjun, Cowley, Michael, Veldhuis, Johannes D and Chen, Chen (2020). Dapagliflozin restores insulin and growth hormone secretion in obese mice. Journal of Endocrinology, 245 (1), 1-12. doi: 10.1530/JOE-19-0385
Liu, Wei, Wang, Zi, Leng, Jing, Wei, Heng, Ren, Shen, Gong, Xiaojie, Chen, Chen, Wang, Yingping, Zhang, Rui and Li, Wei (2020). 20(R)-ginsenoside Rg3, a product of high-efficiency thermal deglycosylation of ginsenoside Rd, exerts protective effects against scrotal heat-induced spermatogenic damage in mice. Biocell, 44 (4), 655-669. doi: 10.32604/biocell.2020.013202
Wang, Zhihong, Dong, Siyuan, Chen, Qun, Chen, Chen, Xu, Zhao and Dong, Zhaoheng (2019). Analysis of the MicroRNA profile by sequencing in ovarian granular cells from women suffering fluorosis with reproductive dysfunction. Biological Trace Element Research, 197 (1), 101-106. doi: 10.1007/s12011-019-01990-2
Huang, Lili, Huang, Zhengxiang and Chen, Chen (2019). Rhythmic growth hormone secretion in physiological and pathological conditions: lessons from rodent studies. Molecular and Cellular Endocrinology, 498 110575, 110575. doi: 10.1016/j.mce.2019.110575
Chen, Yang, Huang, Lili, Qi, Xinzhou and Chen, Chen (2019). Insulin receptor trafficking: consequences for insulin sensitivity and diabetes. International Journal of Molecular Sciences, 20 (20) 5007, 5007. doi: 10.3390/ijms20205007
Sha, Ji-yue, Zhou, Yan-dan, Yang, Jia-yu, Leng, Jing, Li, Jian-hao, Hu, Jun-nan, Liu, Wei, Jiang, Shuang, Wang, Ying-ping, Chen, Chen and Li, Wei (2019). Maltol (3-hydroxy-2-methyl-4-pyrone) slows D-galactose-induced brain aging process by damping the Nrf2/HO-1-mediated oxidative stress in mice. Journal of Agricultural and Food Chemistry, 67 (37), 10342-10351. doi: 10.1021/acs.jafc.9b04614
Xing, Jing-jing, Hou, Jin-gang, Ma, Zhi-na, Wang, Zi, Ren, Shen, Wang, Ying-ping, Liu, Wen-cong, Chen, Chen and Li, Wei (2019). Ginsenoside Rb3 provides protective effects against cisplatin-induced nephrotoxicity via regulation of AMPK-/mTOR-mediated autophagy and inhibition of apoptosis in vitro and in vivo. Cell Proliferation, 52 (4) e12627, e12627. doi: 10.1111/cpr.12627
Chen, Longhui, Wu, Min, Zhang, Shengnan, Tan, Wenjuan, Guan, Min, Feng, Liqiang, Chen, Chen, Tao, Jun, Chen, Ling and Qu, Linbing (2019). Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (7), 7942-7952. doi: 10.1096/fj.201802704R
Aaboud, M., Aad, G., Abbott, B., Abbott, D. C., Abdinov, O., Abud, A. Abed, Abhayasinghe, D. K., Abidi, S. H., AbouZeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Adachi, S., Adam, L., Adamczyk, L., Adamek, L., Adelman, J., Adersberger, M., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C. ... Woods, N. (2019). Combinations of single-top-quark production cross-section measurements and |fLVVtb| determinations at √s=7 and 8 TeV with the ATLAS and CMS experiments. Journal of High Energy Physics (5) ARTN 088. doi: 10.1007/JHEP05(2019)088
Wu, Yanheng, Gu, Wenyi, Li, Jiang, Chen, Chen and Xu, Zhi Ping (2019). Silencing PD-1 and PD-L1 with nanoparticle-delivered small interfering RNA increases cytotoxicity of tumor-infiltrating lymphocytes. Nanomedicine, 14 (8), 955-967. doi: 10.2217/nnm-2018-0237
Le, Minh Tam, Le, Viet Nguyen Sa, Le, Dinh Duong, Nguyen, Vu Quoc Huy, Chen, Chen and Cao, Ngoc Thanh (2019). Exploration of the role of anti-Mullerian hormone and LH/FSH ratio in diagnosis of polycystic ovary syndrome. Clinical Endocrinology, 90 (4), 579-585. doi: 10.1111/cen.13934
Chen, Chen, Su, Weiwei, Liu, Yanyan, Zhang, Jiawen, Zuo, Changjing, Yao, Zhenwei and Bu, Wenbo (2019). Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy. Biomaterials, 200, 48-55. doi: 10.1016/j.biomaterials.2019.02.007
Chen, Qun, Zhang, Xiaotian, Xiong, Yongmin, Chen, Chen and Lv, Shemin (2019). The CD25+/CD4+ T cell ratio and levels of CII, CIX and CXI antibodies in serum may serve as biomarkers of pristane-induced arthritis in rats and Rheumatoid Arthritis in humans. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 217, 25-31. doi: 10.1016/j.cbpc.2018.11.013
Leng, Jing, Hou, Jin-gang, Fu, Cheng-lin, Ren, Shen, Jiang, Shuang, Wang, Ying-ping, Chen, Chen, Wang, Zi and Li, Wei (2019). Platycodon grandiflorum Saponins attenuate scrotal heat-induced spermatogenic damage via inhibition of oxidative stress and apoptosis in mice. Journal of Functional Foods, 54, 479-488. doi: 10.1016/j.jff.2019.01.050
Chen, Chen and Gao, Feng-Hou (2019). Th17 Cells Paradoxical Roles in Melanoma and Potential Application in Immunotherapy. Frontiers in Immunology, 10 187, 1-8. doi: 10.3389/fimmu.2019.00187
Wu, Yanheng, Gu, Wenyi, Li, Li, Chen, Chen and Xu, Zhi (2019). Enhancing PD-1 gene silence in T lymphocytes by comparing the delivery performance of two inorganic nanoparticle platforms. Nanomaterials, 9 (2) 159, 159. doi: 10.3390/nano9020159
Zhou, Yan-dan, Hou, Jin-gang, Yang, Ge, Jiang, Shuang, Chen, Chen, Wang, Zi, Liu, Ying-ying, Ren, Shen and Li, Wei (2019). Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway. Biomedicine and Pharmacotherapy, 109, 2309-2317. doi: 10.1016/j.biopha.2018.11.108
Mi, Xiao-Jie, Hou, Jin-Gang, Jiang, Shuang, Liu, Zhi, Tang, Shan, Liu, Xiang-Xiang, Wang, Ying-Ping, Chen, Chen, Wang, Zi and Li, Wei (2019). Maltol mitigates thioacetamide-induced liver fibrosis through TGF-β1-mediated activation of PI3K/Akt signaling pathway. Journal of Agricultural and Food Chemistry, 67 (5), 1392-1401. doi: 10.1021/acs.jafc.8b05943
Li, Rong-Yan, Zhang, Wei-Zhe, Yan, Xiao-Tong, Hou, Jin-Gang, Wang, Zi, Ding, Chuan-Bo, Liu, Wen-Cong, Zheng, Yi-Nan, Chen, Chen, Li, Yue-Ru and Li, Wei (2019). Arginyl-fructosyl-glucose, a Major Maillard Reaction Product of Red Ginseng, Attenuates Cisplatin-Induced Acute Kidney Injury by Regulating Nuclear Factor κb and Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathways. Journal of Agricultural and Food Chemistry, 67 (20) acs.jafc.9b00540, 5754-5763. doi: 10.1021/acs.jafc.9b00540
Ren, Shen, Leng, Jing, Xu, Xing-Yue, Jiang, Shuang, Wang, Ying-Ping, Yan, Xiao-Tong, Liu, Zhi, Chen, Chen, Wang, Zi and Li, Wei (2019). Ginsenoside Rb1, a major saponin from Panax ginseng, exerts protective effects against acetaminophen-induced hepatotoxicity in mice. American Journal of Chinese Medicine, 47 (8), 1815-1831. doi: 10.1142/S0192415X19500927
Yang, Jin-Kui, Lu, Jing, Yuan, Sha-Sha, Asan,, Cao, Xi, Qiu, Hai-Yan, Shi, Ting-Ting, Yang, Fang-Yuan, Li, Qian, Liu, Cui-Ping, Wu, Qian, Wang, Yu-Hui, Huang, Hai-Xia, Kayoumu, Abudurexiti, Feng, Jian-Ping, Xie, Rong-Rong, Zhu, Xiao-Rong, Liu, Chang, Yang, Guang-Ran, Zhang, Ming-Rong, Xie, Chun-Lan, Chen, Chen, Zhang, Bo, Liu, George, Zhang, Xiu-Qing and Xu, Aimin (2018). From hyper- to hypoinsulinemia and diabetes: effect of KCNH6 on insulin secretion. Cell Reports, 25 (13), 3800-3810. doi: 10.1016/j.celrep.2018.12.005
Xu, Xing-Yue, Wang, Zi, Ren, Shen, Leng, Jing, Hu, Jun-nan, Liu, Zhi, Chen, Chen and Li, Wei (2018). Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways. Phytomedicine, 51, 128-138. doi: 10.1016/j.phymed.2018.09.234
Fu, Cheng-lin, Liu, Ying, Leng, Jing, Zhang, Jing, He, Yu-fang, Chen, Chen, Wang, Zi and Li, Wei (2018). Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice. Biomedicine and Pharmacotherapy, 107, 867-877. doi: 10.1016/j.biopha.2018.08.082
Mi, Xiao-jie, Hou, Jin-gang, Wang, Zi, Han, Ye, Ren, Shen, Hu, Jun-nan, Chen, Chen and Li, Wei (2018). The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways. Scientific Reports, 8 (1) 15922, 15922. doi: 10.1038/s41598-018-34156-6
Zhang, Xinli, Yang, Jin-Kui and Chen, Chen (2018). Enhanced pulsatile growth hormone secretion and altered metabolic hormones by in vivo hexarelin treatment in streptozotocin-induced diabetic rats. International Journal of Molecular Sciences, 19 (10) 3067, 3067. doi: 10.3390/ijms19103067
Zhang, Weizhe, Hou, Jingang, Yan, Xiaotong, Leng, Jing, Li, Rongyan, Zhang, Jing, Xing, Jingjing, Chen, Chen, Wang, Zi and Li, Wei (2018). Platycodon grandiflorum saponins ameliorate cisplatin-induced acute nephrotoxicity through the NF-κB-mediated inflammation and PI3K/Akt/apoptosis signaling pathways. Nutrients, 10 (9) 1328, 1-16. doi: 10.3390/nu10091328
Zhen, Xi May, Li, Xue and Chen, Chen (2018). Metformin versus insulin for gestational diabetes: the reporting of ethnicity and a meta-analysis combining English and Chinese literatures. Obesity Medicine, 11, 48-58. doi: 10.1016/j.obmed.2018.08.001
Leng, Jing, Wang, Zi, Fu, Cheng-Lin, Zhang, Jing, Ren, Shen, Hu, Jun-Nan, Jiang, Shuang, Wang, Ying-Ping, Chen, Chen and Li, Wei (2018). NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice. Phytotherapy Research, 32 (11), 2235-2246. doi: 10.1002/ptr.6160
May Zhen, Xi, Li, Xue and Chen, Chen (2018). Longer-term outcomes in offspring of GDM mothers treated with metformin versus insulin. Diabetes Research and Clinical Practice, 144, 82-92. doi: 10.1016/j.diabres.2018.07.002
Zhou, Yan-Dan, Hou, Jin-Gang, Liu, Wei, Ren, Shen, Wang, Ying-Ping, Zhang, Rui, Chen, Chen, Wang, Zi and Li, Wei (2018). 20(R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis. International Immunopharmacology, 59, 21-30. doi: 10.1016/j.intimp.2018.03.030
Hidalgo, Alejandro, Glass, Nick, Ovchinnikov, Dmitry, Yang, Seung-Kwon, Zhang, Xinli, Mazzone, Stuart, Chen, Chen, Wolvetang, Ernst and Cooper-White, Justin (2018). Modelling ischemia-reperfusion injury (IRI) in vitro using metabolically matured induced pluripotent stem cell-derived cardiomyocytes. APL Bioengineering, 2 (2) 026102, 026102. doi: 10.1063/1.5000746
Wu, Yanheng, Gu, Wenyi, Chen, Chen, Do, Son Trong and Xu, Zhi Ping (2018). Optimization of formulations consisting of layered double hydroxide nanoparticles and small interfering RNA for efficient knockdown of the target gene. ACS Omega, 3 (5), 4871-4877. doi: 10.1021/acsomega.8b00397
Yan, Xiao-Tong, Sun, Yin-Shi, Ren, Shen, Zhao, Li-Chun, Liu, Wen-Cong, Chen, Chen, Wang, Zi and Li, Wei (2018). Dietary α-mangostin provides protective effects against acetaminophen-induced hepatotoxicity in mice via Akt/mTOR-mediated inhibition of autophagy and apoptosis. International Journal of Molecular Sciences, 19 (5) 1335, 1335. doi: 10.3390/ijms19051335
McDonald, Hayley, Peart, Jason, Kurniawan, Nyoman, Galloway, Graham, Royce, Simon, Samuel, Chrishan S. and Chen, Chen (2018). Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction. Physiological Reports, 6 (9) e13699, e13699. doi: 10.14814/phy2.13699
Wang, Jie, Gu, Wenyi and Chen, Chen (2018). Knocking down insulin receptor in pancreatic beta cell lines with lentiviral-small hairpin RNA reduces glucose-stimulated insulin secretion via decreasing the gene expression of insulin, GLUT2 and Pdx1. International Journal of Molecular Sciences, 19 (4) 985, 985. doi: 10.3390/ijms19040985
Li, Wei and Chen, Chen (2018). Response to the Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice. Journal of Agricultural and Food Chemistry, 66 (7), 1734-1735. doi: 10.1021/acs.jafc.7b05975
Zhang, Xinli, Qu, Linbing, Chen, Ling and Chen, Chen (2018). Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats. Physiological Reports, 6 (4) e13612, e13612. doi: 10.14814/phy2.13612
Mosa, Rasha, Huang, Lili, Li, Hongzhuo, Grist, Michael, LeRoith, Derek and Chen, Chen (2018). Long-term treatment with the ghrelin receptor antagonist [D-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 314 (1), R71-R83. doi: 10.1152/ajpregu.00157.2017
Chen, Chen (2018). Meet our regional editor. Current Medicinal Chemistry, 25 (7), 771-771. doi: 10.2174/092986732507180315155402
Chen, Xiao-Lin and Chen, Chen (2017). Frozen section with improved H&E staining for follicular morphometric analysis of mouse ovary in oestrus cycle. Sheng li xue bao [Acta physiologica Sinica], 69 (6), 781-784.
Chen, Jiezhong, Huang, Xu-Feng, Shao, Renfu, Chen, Chen and Deng, Chao (2017). Molecular Mechanisms of Antipsychotic Drug-Induced Diabetes. Frontiers in Neuroscience, 11 (NOV) 643, 643. doi: 10.3389/fnins.2017.00643
Shi, Ting-Ting, Yang, Fang-Yuan, Liu, Chang, Cao, Xi, Lu, Jing, Zhang, Xue-Lian, Yuan, Ming-Xia, Chen, Chen and Yang, Jin-Kui (2017). Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic β-cells. Biochemical and Biophysical Research Communications, 495 (1), 860-866. doi: 10.1016/j.bbrc.2017.11.055
Qiu, Han, Yang, Jin-Kui and Chen, Chen (2017). Influence of insulin on growth hormone secretion, level and growth hormone signalling. Sheng Li Xue Bao : [Acta physiologica Sinica], 69 (5), 541-556.
Ma, Zhi-na, Liu, Zhi, Wang, Zi, Ren, Shen, Tang, Shan, Wang, Ying-ping, Xiao, Sheng-yuan, Chen, Chen and Li, Wei (2017). Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways. Food and Chemical Toxicology, 110, 62-73. doi: 10.1016/j.fct.2017.10.006
Huang, Xiao-Ting, Yue, Shao-Jie, Li, Chen, Huang, Yan-Hong, Cheng, Qing-Mei, Li, Xiao-Hong, Hao, Cai-Xia, Wang, Ling-Zhi, Xu, Jian-Ping, Ji, Ming, Chen, Chen, Feng, Dan-Dan and Luo, Zi-Qiang (2017). A Sustained Activation of Pancreatic NMDARs Is a Novel Factor of β-Cell Apoptosis and Dysfunction. Endocrinology, 158 (11), 3900-3913. doi: 10.1210/en.2017-00366
Mcdonald, H., Peart, J., Kurniawan, N.D., Galloway, G., Royce, S.G., Samuel, C.S. and Chen, C. (2017). [OP.3B.05] Hexarelin preserves myocardial function and reduces inflammation and fibrosis in a mouse model of myocardial ischemia reperfusion. Journal of Hypertension, 35 (Supplement 2), e29-e29. doi: 10.1097/01.hjh.0000523053.36429.97
Xu, Chun, Lei, Chang, Huang, Lili, Zhang, Jun, Zhang, Hongwei, Song, Hao, Yu, Meihua, Wu, Yeda, Chen, Chen and Yu, Chengzhong (2017). Glucose-responsive nanosystem mimicking the physiological insulin secretion via an enzyme-polymer layer-by-layer coating strategy. Chemistry of Materials, 29 (18), 7725-7732. doi: 10.1021/acs.chemmater.7b01804
Mosa, Rasha, Huang, Lili, Wu, Yeda, Fung, Chungyan, Mallawakankanamalage, Oshini, LeRoith, Derek and Chen, Chen (2017). Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice. Endocrinology, 158 (10), 3174-3187. doi: 10.1210/en.2017-00168
Webster, Julie A., Yang, Zhe, Kim, Yu-Hee, Loo, Dorothy, Mosa, Rasha M., Li, Hongzhuo and Chen, Chen (2017). Collagen beta (1-O) galactosyltransferase 1 (GLT25D1) is required for the secretion of high molecular weight adiponectin and affects lipid accumulation. Bioscience Reports, 37 (3) BSR20170105, BSR20170105. doi: 10.1042/BSR20170105
Wu, Yanheng, Chen, Mingshui, Wu, Peihong, Chen, Chen, Xu, Zhi Ping and Gu, Wenyi (2017). Increased PD-L1 expression in breast and colon cancer stem cells. Clinical and Experimental Pharmacology and Physiology, 44 (5), 602-604. doi: 10.1111/1440-1681.12732
Gatford, Kathryn L., Muhlhausler, Beverly S., Huang, Lili, Sim, Pamela Su-Lin, Roberts, Claire T., Velhuis, Johannes D. and Chen, Chen (2017). Rising maternal circulating GH during murine pregnancy suggests placental regulation. Endocrine Connections, 6 (4), 260-266. doi: 10.1530/EC-17-0032
Yang, Hao Jie, Zhang, Ying, Wang, Zhi Lun, Xue, Sen Hai, Li, Si Yuan, Zhou, Xiao Rong, Zhang, Meng, Fang, Qian, Wang, Wen Jun, Chen, Chen, Deng, Xiang Hua and Chen, Jing Hong (2017). Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency. Biomedical and Environmental Sciences, 30 (5), 351-362. doi: 10.3967/bes2017.046
Maugham, Michelle L., Thomas, Patrick B., Crisp, Gabrielle J., Philp, Lisa K., Shah, Esha T., Herington, Adrian C., Chen, Chen, Gregory, Laura S., Nelson, Colleen C., Seim, Inge, Jeffery, Penny L. and Chopin, Lisa K. (2017). Insights from engraftable immunodeficient mouse models of hyperinsulinaemia. Scientific Reports, 7 (1) 00443, 491. doi: 10.1038/s41598-017-00443-x
Huang, Xiao-Ting, Li, Chen, Peng, Xiang-Ping, Guo, Jia, Yue, Shao-Jie, Liu, Wei, Zhao, Fei-Yan, Han, Jian-Zhong, Huang, Yan-Hong, Yang-Li, Cheng, Qing-Mei, Zhou, Zhi-Guang, Chen, Chen, Feng, Dan-Dan and Luo, Zi-Qiang (2017). An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes. Scientific Reports, 7 (1) 44120, 44120. doi: 10.1038/srep44120
Chen, Xiaolin, Huang, Lili , Tan, Hwee Y., Li, Hongzhuo, Wan, Ying, Cowley, Michael, Veldhuis, Johannes D. and Chen, Chen (2017). Deficient melanocortin-4 receptor causes abnormal reproductive neuroendocrine profile in female mice. Reproduction, 153 (3), 267-276. doi: 10.1530/REP-16-0341
Yang, Jin-Kui, Wang, Ying-Ying, Liu, Chang, Shi, Ting-Ting, Lu, Jing, Cao, Xi, Yang, Fang-Yuan, Feng, Jian-Ping , Chen, Chen, Ji, Li-Non and Xu, Aimin (2017). Urine proteome specific for eye damage can predict kidney damage in patients with type 2 diabetes: a case-control and a 5.3-year prospective cohort study. Diabetes Care, 40 (2), 253-260. doi: 10.2337/dc16-1529
Zhou, Li, Gao, Jing and Chen, Chen (2017). Feasibility analysis of triglyceride as a surrogate marker for insulin resistance in Chinese women with polycystic ovary syndrome. Journal of Shanghai Jiaotong University (Medical Science), 37 (1), 60-63. doi: 10.3969/j.issn.1674-8115.2017.01.013
Chen, Chen (2017). Meet our editorial board member. Current Drug Targets, 18 (7). doi: 10.2174/138945011807170428181919
Liu, Li, Zhao, Fan, Liu, Wei, Zhu, Tong, Zhang, John Z. H., Chen, Chen, Dai, Zhihui, Peng, Huisheng, Huang, Jun-Long, Hu, Qin, Bu, Wenbo and Tian, Yang (2017). An electrochemical biosensor with dual signal outputs: toward simultaneous quantification of pH and O2 in the brain upon ischemia and in a tumor during cancer starvation therapy. Angewandte Chemie (International Edition), 56 (35), 10471-10475. doi: 10.1002/anie.201705615
Tan, H. Y., Steyn, F. J., Huang, L., Cowley, M., Veldhuis, J. D. and Chen, C. (2016). Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone. Journal of Physiology, 594 (24), 7309-7326. doi: 10.1113/JP272770
Yeo, S. -H., Kyle, V., Morris, P. G., Jackman, S., Sinnett-Smith, L. C., Schacker, M., Chen, C. and Colledge, W. H. (2016). Visualisation of Kiss1 neurone distribution using a Kiss1-CRE transgenic mouse. Journal of Neuroendocrinology, 28 (11), 1-12. doi: 10.1111/jne.12435
Li, Wei, Yan, Meng-Han, Liu, Ying, Liu, Zhi, Wang, Zi, Chen, Chen, Zhang, Jing and Sun, Yin-Shi (2016). Ginsenoside Rg5 ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress, and apoptosis. Nutrients, 8 (9) 566, 566. doi: 10.3390/nu8090566
Steyn, Frederik J., Tolle, Virginie, Chen, Chen and Epelbaum, Jacques (2016). Neuroendocrine regulation of growth hormone secretion. Comprehensive Physiology, 6 (2), 687-735. doi: 10.1002/cphy.c150002
Cheng, Feifei, Zhao, Lu, Wu, Yuanyuan, Huang, Tiantian, Yang, Gangyi, Zhang, Zhanyu, Wu, Yijia, Jia, Fang, Wu, Jinlin, Chen, Chen and Liu, Dongfang (2016). Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment. Clinical Endocrinology, 84 (3), 386-393. doi: 10.1111/cen.12950
Zhao, Yan, Zhang, Xinli, Chen, Jiezhong, Lin, Chao, Shao, Renfu, Yan, Chunxia and Chen, Chen (2016). Hexarelin protects rodent pancreatic B-cells function from cytotoxic effects of streptozotocin involving mitochondrial signalling pathways in vivo and in vitro. PLoS ONE, 11 (2) e0149730, e0149730. doi: 10.1371/journal.pone.0149730
Zhang, Yibei, Qiao, Haiou, Chen, Chen, Wang, Zhilun and Xia, Xiaodong (2016). Determination of nitrofurans metabolites residues in aquatic products by ultra-performance liquid chromatography-tandem mass spectrometry. Food Chemistry, 192, 612-617. doi: 10.1016/j.foodchem.2015.07.035
Jiang, Zhihui, Chen, Chen, Wang, Jian, Xie, Wenyan, Wang, Meng, Li, Xinsheng and Zhang, Xiaoying (2016). Purple potato (Solanum tuberosum L.) anthocyanins attenuate alcohol-induced hepatic injury by enhancing antioxidant defense. Journal of Natural Medicines, 70 (1), 45-53. doi: 10.1007/s11418-015-0935-3
Xie, T. Y., Ngo, S. T., Veldhuis, J. D., Jeffery, P. L., Chopin, L. K., Tschop, M., Waters, M. J., Tolle, V., Epelbaum, J., Chen, C. and Steyn, F. J. (2015). Effect of deletion of ghrelin-o-acyltransferase on the pulsatile release of growth hormone in mice. Journal of Neuroendocrinology, 27 (12), 872-886. doi: 10.1111/jne.12327
Chen, Jiezhong, Xu, Tiefeng and Chen, Chen (2015). The critical roles of miR-21 in anti-cancer effects of curcumin. Annals of Translational Medicine, 3 (21) 330, 330. doi: 10.3978/j.issn.2305-5839.2015.09.20
Lv, Lixia, Chen, Hewen, Sun, Jiaying, Lu, Di, Chen, Chen and Liu, Dongfang (2015). PRMT1 promotes glucose toxicity-induced β cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells. Endocrine, 49 (3), 669-682. doi: 10.1007/s12020-015-0543-8
Carrasco-Pozo, Catalina, Gotteland, Martin, Castillo, Rodrigo L. and Chen, Chen (2015). 3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol. Experimental Cell Research, 334 (2), 270-282. doi: 10.1016/j.yexcr.2015.03.021
Mosa, Rasha Mofeed Habeeb, Zhang, Zhen, Shao, Renfu, Deng, Chao, Chen, Jiezhong and Chen, Chen (2015). Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases. Endocrine, 49 (2), 307-323. doi: 10.1007/s12020-015-0531-z
Yi K.J., So K.H., Hata Y., Suzuki Y., Kato D., Watanabe K., Aso H., Kasahara Y., Nishimori K., Chen, Chen, Katoh K. and Roh S.G. (2015). The regulation of oxytocin receptor gene expression during adipogenesis. Journal of Neuroendocrinology, 27 (5), 335-342. doi: 10.1111/jne.12268
Chen, Jiezhong, Gu, Wenyi, Yang, Lei, Chen, Chen, Shao, Renfu, Xu, Kewei and Xu, Zhi Ping (2015). Nanotechnology in the management of cervical cancer. Reviews in Medical Virology, 25 (S1), 72-83. doi: 10.1002/rmv.1825
Guillou, Anne, Romano, Nicola, Steyn, Frederik, Abitbol, Karine, Le Tissier, Paul, Bonnefont, Xavier, Chen, Chen, Mollard, Patrice and Martin, Agnès O. (2015). Assessment of lactotroph axis functionality in mice: longitudinal monitoring of PRL secretion by ultrasensitive-ELISA. Endocrinology, 156 (5), 1-7. doi: 10.1210/en.2014-1571
Chen, Jiezhong, Shao, Renfu and Chen, Chen (2015). Possible therapeutic implication of PDL-1/PD-1 axis in endometrial cancer. Journal of Solid Tumors, 5 (1), 10-17. doi: 10.5430/jst.v5n1p10
Chen, Chen (2015). Meet the editorial board. Current Drug Targets, 16 (3), 179-179. doi: 10.2174/138945011603150313234542
Chen, Chen (2015). Meet our editorial board member. Current Drug Targets, 16 (14), 1563-1563. doi: 10.2174/138945011614151119110133
Huang, Lili, Tan, Hwee Y., Fogarty, Matthew J., Andrews, Zane B., Veldhuis, Johannes D., Herzog, Herbert, Steyn, Frederik J. and Chen, Chen (2014). Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state. Journal of Neuroscience, 34 (49), 16309-16319. doi: 10.1523/JNEUROSCI.4622-13.2014
Ovchinnikov, Dmitry A.,, Hidalgo, Alejandro, Yang, Seung-Kwon, Zhang, Xinli, Hudson, James, Mazzone, Stuart B., Chen, Chen, Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporter. Stem Cells and Development, 24 (1), 11-20. doi: 10.1089/scd.2014.0195
Chen, Jiezhong, Zhao, Kong-Nan, Li, Rui, Shao, Renfu and Chen, Chen (2014). Activation of PI3K/Akt/mTOR pathway and dual inhibitors of PI3K and mTOR in endometrial cancer. Current Medicinal Chemistry, 21 (26), 3070-3080. doi: 10.2174/0929867321666140414095605
Chen, Chen, Chen, Jiezhong and Zhao, Kong-Nan (2014). Signalling pathways in anti-cancer drug resistance. Current Medicinal Chemistry, 21 (26), 3007-3008. doi: 10.2174/092986732126140804160443
Zhou, Xiaorong, Wang, Zhilun, Chen, Jinghong, Wang, Wei, Song, Daiqing, Li, Siyuan, Yang, Haojie, Xue, Senhai and Chen, Chen (2014). Increased levels of IL-6, IL-1β, and TNF-α in Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency. Rheumatology International, 34 (7), 995-1004. doi: 10.1007/s00296-013-2862-5
Chen, Jiezhong, Elfiky, Aymen, Han, Mei, Chen, Chen and Saif, M. Wasif (2014). The role of Src in colon cancer and its therapeutic implications. Clinical Colorectal Cancer, 13 (1), 5-13. doi: 10.1016/j.clcc.2013.10.003
Li, Shengbin, Li, Bo, Cheng, Cheng, Xiong, Zijun, Liu, Qingbo, Lai, Jianghua, Carey, Hannah V., Zhang, Qiong, Zheng, Haibo, Zheng, Haibo, Wei, Shuguang, Zhang, Hongbo, Chang, Liao, Liu, Shiping, Zhang, Shanxin, Yu, Bing, Zeng, Xiaofan, Huo, Yong, Nie, Wenhui, Guo, Youmin, Chen, Teng, Han, Jiuqiang, Wang, Jian, Wang, Jun, Chen, Chen, Liu, Jiankang, Stambrook, Peter J., Xu, Ming, Zhang, Guojie ... Yan, Jianqun (2014). Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species. Genome Biology, 15 (557) 557, 1-16. doi: 10.1186/s13059-014-0557-1
Chen, Jiezhong, Zhao, Kong-Nan and Chen, Chen (2014). The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis. Annals of Translational Medicine, 2 (1) 7, 7-7. doi: 10.3978/j.issn.2305-5839.2013.03.02
Hassouna, Rim, Zizzari, Philippe, Tomasetto, Catherine, Veldhuis, Johannes D., Fiquet, Oriane, Labarthe, Alexandra, Cognet, Julie, Steyn, Frederik, Chen, Chen, Epelbaum, Jacques and Tolle, Virginie (2014). An early reduction in GH peak amplitude in preproghrelin deficient male mice has a minor impact on linear growth. Endocrinology, 155 (9), 3561-3571. doi: 10.1210/en.2014-1126
Manzanero, Silvia, Erion, Joanna R., Santro, Tomislay, Steyn, Frederik J., Chen, Chen, Arumugam, Thiruma V. and Stranahan, Alexis M. (2014). Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery. Journal of Cerebral Blood Flow and Metabolism, 34 (5), 897-905. doi: 10.1038/jcbfm.2014.36
Chen, Jinghong, Cao, Junling, Wang, Zhilun, Ma, Tianyou, Wang, Mengying, He, Ying, Yang, Zhantian and Chen, Chen (2014). Correlation of matrix metalloproteinases and Kashin-Beck disease. Chinese Journal of Endemiology, 33 (4), 357-362.
Chen, Chen, Chen, Jinghong, Cao, Junling, Wang, Wei, Zhang, Zengtie, Yang, Zhantian, Yu, Boquan and Ma, Tianyou (2014). 大骨节病儿童软骨白细胞介素-1β、白细胞介素-6及肿瘤坏死因子-α的表达. Chinese Journal of Endemiology, 33 (4), 363-366. doi: 10.3760/cma.j.issn.2095-4255.2014.04.003
Steyn F.J., Wan Y., Clarkson J., Veldhuis J.D., Herbison A.E. and Chen C. (2013). Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice. Endocrinology, 154 (12), 4939-4945. doi: 10.1210/en.2013-1502
Steyn, F. J., Lee, Kevin, Fogarty, M. J., Veldhuis, J. D., McCombe, P. A,, Bellingham, M. C., Ngo, S. T. and Chen, C (2013). Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice. Endocrinology, 154 (12), 4695-4706. doi: 10.1210/en.2013-1570
Chen J., Crawford R., Chen C. and Xiao Y. (2013). The key regulatory roles of the PI3K/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration. Tissue Engineering - Part B: Reviews, 19 (6), 516-528. doi: 10.1089/ten.teb.2012.0672
Xu Zhao, Wang Zhou, Li Jian-jun, Chen Chen, Zhang Ping-chuan, Dong Lu, Chen Jing-hong, Chen Qun, Zhang Xiao-tian and Wang Zhi-lun (2013). Protective effects of selenium on oxidative damage and oxidative stress related gene expression in rat liver under chronic poisoning of arsenic. Food and Chemical Toxicology, 58, 1-7. doi: 10.1016/j.fct.2013.03.048
Zhao, Yu-Feng, Wang, Li, Zha, Dingjun, Qiao, Li, Lu, Lianjun, Yu, Jun, Qu, Ping, Sun, Qiang, Qiu, Jianhua and Chen, Chen (2013). GW9508 inhibits insulin secretion by activating ATP-sensitive potassium channels in rat pancreatic beta-cells. Journal of Molecular Endocrinology, 51 (1), 69-77. doi: 10.1530/JME-13-0019
Steyn, F. J., Xie, T. Y., Huang, L., Ngo, S. T., Veldhuis, J. D., Waters, M. J. and Chen, C. (2013). Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain. Journal of Endocrinology, 218 (2), 233-244. doi: 10.1530/JOE-13-0084
Fung, Jenny N. T., Jeffery, Penny L., Lee, John D., Seim, Inge, Roche, Deborah, Obermair, Andreas, Chopin, Lisa K. and Chen, Chen (2013). Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivo. American Journal of Physiology-Endocrinology and Metabolism, 305 (2), E305-E313. doi: 10.1152/ajpendo.00156.2013
Chen, Jiezhong, Shao, Renfu, Zhang, Xu Dong and Chen, Chen (2013). Applications of nanotechnology for melanoma treatment, diagnosis, and theranostics. International Journal of Nanomedicine, 8 (1), 2677-2688. doi: 10.2147/IJN.S45429
Zhao, Yufeng, Wang, Li, Qiu, Jianhua, Zha, Dingjun, Sun, Qiang and Chen, Chen (2013). Linoleic acid stimulates [Ca2+]i increase in rat pancreatic Beta-Cells through both membrane receptor- and intracellular metabolite-mediated pathways. PLoS One, 8 (4) e60255, e60255.1-e60255.9. doi: 10.1371/journal.pone.0060255
Wu, Jianghong, Chen, Chen and Zhao, Kong-Nan (2013). Phosphatidylinositol 3-kinase signaling as a therapeutic target for cervical cancer. Current Cancer Drug Targets, 13 (2), 143-156. doi: 10.2174/1568009611313020004
Du, Lai-Ling, Xie, Jia-Zhao, Cheng, Xiang-Shu, Li, Xiao-Hong, Kong, Fan-Li, Jiang, Xia, Ma, Zhi-Wei, Wang, Jian-Zhi, Chen, Chen and Zhou, Xin-Wen (2013). Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age, 36 (2), 613-623. doi: 10.1007/s11357-013-9592-1
Zou, H., Gan, X. L., Linghu, L. J., Chen, C., Hu, L. N. and Zhang, Y. (2013). Intense nanosecond pulsed electric fields promote cancer cell apoptosis through centrosome-dependent pathway involving reduced level of PLK1. European Review for Medical and Pharmacological Sciences, 17 (2), 152-160.
Gu, Wenyi, Chen, Chen and Zhao, Kong-Nan (2013). Obesity-associated endometrial and cervical cancers. Frontiers in Bioscience, 5 (1) E600, 109-118. doi: 10.2741/e600
Zhao, Yufeng, Zha, Dingjun, Wang, Li, Qiao, Li, Lu, Lianjun, Mei, Lin, Chen, Chen and Qiu, Jianhua (2013). Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas. Tissue and Cell, 45 (6), 421-427. doi: 10.1016/j.tice.2013.07.005
Chen, Jiezhong, Chi, Mengna, Chen, Chen and Zhang, Xu Dong (2013). Obesity and melanoma: exploring molecular links. Journal of Cellular Biochemistry, 114 (9), 1955-1961. doi: 10.1002/jcb.24549
Tan, H. Y., Huang, L., Simmons, D., Veldhuis, J. D., Steyn, F. J. and Chen, C. (2013). Hypothalamic distribution of somatostatin mRNA expressing neurones relative to pubertal and adult changes in pulsatile growth hormone secretion in mice. Journal of Neuroendocrinology, 25 (10), 910-919. doi: 10.1111/jne.12078
Ling, Liang-han, Khammy, Ouda, Byrne, Melissa, Amirahmadi, Fatemah, Foster, Anna, Li, Gefeng, Zhang, Linda, dos Remedios, Cris, Chen, Chen and Kaye, David M. (2012). Irregular rhythm adversely influences calcium handling in ventricular myocardium: implications for the interaction between heart failure and atrial fibrillation. Circulation: Heart Failure, 5 (6), 786-793. doi: 10.1161/CIRCHEARTFAILURE.112.968321
Rao, J. R., Keating, D. J., Chen, C. and Parkington, H. C. (2012). Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPAR gamma-dependent and PPAR gamma-independent mechanisms. Diabetes Obesity & Metabolism, 14 (11), 983-989. doi: 10.1111/j.1463-1326.2012.01626.x
Ma, Yi, Zhang, Lin, Launikonis, Bradley S. and Chen, Chen (2012). Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in Vitro ischemia/reperfusion heart. Endocrinology, 153 (11), 5480-5490. doi: 10.1210/en.2012-1404
Xu, Xiangbin, Ding, Fan, Pang, Jinjiang, Gao, Xue, Xu, Rong-Kun, Hao, Wei, Cao, Ji-Min and Chen, Chen (2012). Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat. American Journal of Physiology Heart and Circulatory Physiology, 303 (6), H703-H711. doi: 10.1152/ajpheart.00257.2011
Chen, Jing-hong, Xue, Senghai, Li, Siyuan, Wang, Zhi-lun, Yang, Haojie, Wang, Wei, Song, Daiqing, Zhou, Xiaorong and Chen, Chen (2012). Oxidant damage in Kashin-Beck disease and a rat Kashin-Beck disease model by employing T-2 toxin treatment under selenium deficient conditions. Journal of Orthopaedic Research, 30 (8), 1229-1237. doi: 10.1002/jor.22073
Huang, L., Steyn, F. J., Tan, H. Y., Xie, T. Y., Veldhuis, J. D., Ngo, S. T. and Chen, C. (2012). The decline in pulsatile GH secretion throughout early adulthood in mice is exacerbated by dietary-induced weight gain. Endocrinology, 153 (9), 4380-4388. doi: 10.1210/en.2012-1178
Zhang, Xinli and Chen, Chen (2012). A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy. Endocrine, 41 (3), 398-409. doi: 10.1007/s12020-012-9623-1
Tuo, Ya, Feng, Dan Dan, Wang, Deng-Feng, Sun, Jian, Li, Sheng-Bin and Chen, Chen (2012). Long-term in vitro treatment of INS-1 rat pancreatic beta-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors. Clinical and Experimental Pharmacology and Physiology, 39 (5), 423-428. doi: 10.1111/j.1440-1681.2012.05691.x
Ma, Yi, Zhang, Lin, Edwards, Joshua N., Launikonis, Breadley S. and Chen, Chen (2012). Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. PLoS One, 7 (4) e35265, e35265.1-e35265.9. doi: 10.1371/journal.pone.0035265
Yang, Seung-Kwon, Steyn, Frederik and Chen, Chen (2012). Influence of membrane ion channel in pituitary somatotrophs by hypothalamic regulators. Cell Calcium, 51 (3-4), 231-239. doi: 10.1016/j.ceca.2011.12.005
Steyn, F. J., Ngo, S. T, Lee, J. D., Leong, J. W., Buckley, A. J., Veldhuis, J. D., McCombe, P. A., Chen, C. and Bellingham, M. C. (2012). Impairments to the GH-IGF-I axis in hSOD1(G93A) mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis. Endocrinology, 153 (8), 3735-3746. doi: 10.1210/en.2011-2171
Steyn, F. J., Leong, J. W., Huang, L., Tan, H. Y., Xie, T. Y., Nelson, C., Waters, M. J., Veldhuis, J. D., Epelbaum, J. and Chen, C. (2012). GH does not modulate the early fasting-induced release of free fatty acids in mice. Endocrinology, 153 (1), 273-282. doi: 10.1210/en.2011-1681
Zou, Heng, Wang, Dengfeng, Can, Xiaoling, Jiang, Long, Chen, Chen, Hu, Lina and Zhang, Yi (2011). Low TWEAK expression is correlated to the progression of squamous cervical carcinoma. Gynecologic Oncology, 123 (1), 123-128. doi: 10.1016/j.ygyno.2011.07.003
Feng, Dan D., Yang, Seung-Kwon, Loudes, Catherine, Simon, Axelle, Al-Sarraf, Tamara, Culler, Michael, Alvear-Perez, Rodrigo, Llorens-Cortes, Catherine, Chen, Chen, Epelbaum, Jacques and Gardette, Robert (2011). Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons. European Journal of Neuroscience, 34 (5), 732-744. doi: 10.1111/j.1460-9568.2011.07787.x
Wang, Li, Zhao, Yufeng, Gui, Baosong, Fu, Rongguo, Ma, Feng, Yu, Jun, Qu, Ping, Dong, Lei and Chen, Chen (2011). Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+](i) increase in pancreatic islet alpha-cells. Journal of Endocrinology, 210 (2), 173-179. doi: 10.1530/JOE-11-0132
Steyn, F. J., Huang, L., Ngo, S. T., Leong, J. W., Tan, H. Y., Xie, T. Y., Parlow, A. F., Veldhuis, J. D., Waters, M. J. and Chen, C. (2011). Development of a method for the determination of pulsatile growth hormone secretion in mice. Endocrinology, 152 (8), 3165-3171. doi: 10.1210/en.2011-0253
Tuo, Ya, Wang, Dengfeng, Li, Shengbin and Chen, Chen (2011). Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways. Endocrine, 39 (2), 128-138. doi: 10.1007/s12020-010-9432-3
Han, Xuefeng, Zhu, Yunlong, Zhao, Yufeng and Chen, Chen (2011). Ghrelin reduces voltage-gated calcium currents in GH3 cells via cyclic GMP pathways. Endocrine, 40 (2), 228-236. doi: 10.1007/s12020-011-9520-z
Wang, L., Fu, Rong-Guo, Liu, Xiao-Dan, Gui, Bao-Song, Sun, Qiang, Chen, Chen, Zhao, Yu-Feng and Dong, Lei (2010). [Effects of linoleic acid on intracellular calcium concentration in primarily cultured rat pancreatic β-cells and underlying mechanism]. Sheng li xue bao : [Acta physiologica Sinica], 62 (6), 529-534.
Fung, Jenny N. T., Seim, Inge, Wang, Dengfeng, Obermair, Andreas, Chopin, Lisa K. and Chen, Chen (2010). Expression and in vitro functions of the ghrelin axis in endometrial cancer. Hormone and Cancer, 1 (5), 245-255. doi: 10.1007/s12672-010-0047-1
Sun, Qiang, Ma, Yi, Zhang, Lin, Zhao, Yu-Feng, Zang, Wei-Jin and Chen, Chen (2010). Effects of GH secretagogues on contractility and Ca2+ homeostasis of isolated adult rat ventricular myocytes. Endocrinology, 151 (9), 4446-4454. doi: 10.1210/en.2009-1432
Wang, Dengfeng, Hu, Lina, Zhang, Guonan, Zhang, Lin and Chen, Chen (2010). G protein-coupled receptor 30 in tumor development. Endocrine, 38 (1), 29-37. doi: 10.1007/s12020-010-9363-z
Wang, Dengfeng, Fung, Jenny Nga Ting Fung, Tuo, Ya, Hu, Lina and Chen, Chen (2010). TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway. Cancer Letters, 294 (1), 91-100. doi: 10.1016/j.canlet.2010.01.027
孙 强 Sun, Qiang, 胡 浩 Hu, Hao, 周 筠 Zhou, Jun, 于小江 Yu, Xiao-jiang, 臧伟进 Zang, Wei-jin and 陈 晨 Chen, Chen (2010). 肥胖抑制素对大鼠心室肌细胞收缩及L-型钙通道的影响. Xi'an Jiaotong Daxue Xuebao (Yixue Ban), 31 (4), 447-449.
Pang, Jinjiang, Xu, Qihua, Xu, Xiangbin, Yin, Hongchao, Xu, Rongkun, Guo, Shu, Hao, Wei, Wang, Luya, Chen, Chen and Cao, Ji-Min (2010). Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat. Peptides, 31 (4), 630-638. doi: 10.1016/j.peptides.2009.11.007
Sun, Qiang, Zang, Wei-Jin and Chen, Chen (2010). Growth hormone secretagogues reduce transient outward K+ current via phospholipase C/protein kinase C signaling pathway in rat ventricular myocytes. Endocrinology, 151 (3), 1228-1235. doi: 10.1210/en.2009-0877
Zhao, Yu-Feng, Wang, Li, Lee, Soohyun, Sun, Qiang, Tuo, Ya, Wang, Yuemin, Pei, Jianming and Chen, Chen (2010). Cholesterol induces mitochondrial dysfunction and apoptosis in mouse pancreatic beta-cell line MIN6 cells. Endocrine, 37 (1), 76-82. doi: 10.1007/s12020-009-9275-y
Chu, Kwan Yi, Cheng, Qianni, Chen, Chen, Au, Lai Shan, Seto, Sai Wang, Tuo, Ya, Motin, Leonid, Kwan, Yiu Wa and Leung, Po Sing (2010). Angiotensin II exerts glucose-dependent effects on K-v currents in mouse pancreatic beta-cells via angiotensin II type 2 receptors. American Journal of Physiology - Cell Physiology, 298 (2), C313-C323. doi: 10.1152/ajpcell.00575.2008
Steyn, F. J., Boehme, F., Vargas, E., Wang, K., Parkington, H. C., Rao, J. R. and Chen, C. (2009). Adiponectin Regulate Growth Hormone Secretion Via Adiponectin Receptor Mediated Ca2+ Signalling in Rat Somatotrophs In Vitro. Journal of Neuroendocrinology, 21 (8), 698-704. doi: 10.1111/j.1365-2826.2009.01887.x
Chen, Chen and Sun, Qiang (2009). Discovery and research progress of ghrelin. Journal of Xi’an Jiaotong University (Medical Sciences), 30 (2), 131-136.
Yang, Seung Kwon, Wang, Kun, Parkington, Helena and Chen, Chen (2008). Involvement of tetrodotoxin-resistant Na+ current and protein kinase C in the action of growth hormone (GH)-releasing hormone on primary cultured somatotropes from GH-green fluorescent protein transgenic mice. Endocrinology, 149 (9), 4726-4735. doi: 10.1210/en.2008-0405
Zhao, Yu-Feng, Pei, Jianming and Chen, Chen (2008). Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. Journal of Endocrinology, 198 (3), 533-540. doi: 10.1677/JOE-08-0105
Wang, J., Chen, C. and Wang, R. Y. (2008). Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats. Endocrine, 33 (1), 77-83. doi: 10.1007/s12020-008-9056-z
Feng, Dan Dan, Zhao, Yufeng, Luo, Zi-Qiang, Keating, Damien and Chen, Chen (2008). Linolei acid induces Ca2+ -induced inactivation of voltage dependent Ca2+ currents in rat pancreatic beta-cells. Journal of Endocrinology, 196 (2), 377-384. doi: 10.1677/JOE-07-0426
Lepore, DA, Knight, KR, Thomas, PQ and Chen Chen (2008). Generation of growth hormone expressing cells in a vascularised bioengineered microchamber. Topics in Tissue Engineering, 4, 1-16.
Keating, Damien J., Dubach, Daphne, Zanin, Mark P., Yu, Yong, Martin, Katherine, Zhao, Yu-Feng, Chen, Chen, Port, Sı´lvia, Arbone´s, Maria L., Mittaz, Laureane and Pritchard, Melanie A. (2008). DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: Implications for Down syndrome and Alzheimer's disease. Human Molecular Genetics, 17 (7), 1020-1030. doi: 10.1093/hmg/ddm374
Smart, R., Kiely, A., Beale, M., Vargas, E., Carraher, C., Kralicek, A. V., Christie, D. L., Chen, C., Newcomb, R. D. and Warr, C. G. (2008). Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins. Insect Biochemistry and Molecular Biology, 38 (8), 770-780. doi: 10.1016/j.ibmb.2008.05.002
Quan, Annie, McGeachie, Andrew B., Keating, Damien J., van Dam, Ellen M., Rusak, Jenny, Chau, Ngoc, Malladi, Chandra S., Chen, Chen, McCluskey, Adam, Cousin, Michael A. and Robinson, Phillip J. (2007). Myristyl Trimethyl Ammonium Bromide and Octadecyl Trimethyl Ammonium Bromide Are Surface-Active Small Molecule Dynamin Inhibitors that Block Endocytosis Mediated by Dynamin I or Dynamin II. Molecular Pharmacology, 72 (6), 1425-1439. doi: 10.1124/mol.107.034207
Yang, Seung-Kwon and Chen, Chen (2007). Involvement of somatostatin receptor subtypes in membrane ion channel modification by somatostatin in pituitary somatotropes. Clinical and Experimental Pharmacology and Physiology, 34 (12), 1221-1227. doi: 10.1111/j.1440-1681.2007.04806.x
Xu, Xiangbin, Pang, Jinjiang, Yin, Hongchao, Li, Meixiu, Hao, Wei, Chen, Chen and Cao, Ji-Min (2007). Hexarelin suppresses cardiac fibroblast proliferation and collagen synthesis in rat. American Journal of Physiology - Heart and Circulatory Physiology, 293 (5), 2952-2958. doi: 10.1152/ajpheart.00004.2007
Tawadros, N., Salamonsen, L. A., Dimitriadis, L. E. and Chen, C. (2007). Facilitation of decidualization by locally produced ghrelin in the human endometrium. Molecular Human Reproduction, 13 (7), 483-489. doi: 10.1093/molehr/gam029
Zhao, Y. F. and Chen, C. (2007). Regulation of pancreatic β-cell function by adipocytes. Shengli Xuebao (Acta physiologica Sinica), 59 (3), 247-252.
Yang, Seung-Kwon, Parkington, Helena C., Epelbaum, Jacques, Keating, Damien J. and Chen, Chen (2007). Somatostatin decreases voltage-gated Ca2+ currents in GH3 cells through activation of somatostatin receptor 2. American Journal of Physiology: Endocrinology and Metabolism, 292 (6), E1863-E1870. doi: 10.1152/ajpendo.00047.2007
Zhao, Yu-Feng, Feng, Dan-Dan, Hernandez, Maria and Chen, Chen (2007). 3T3-L1 adipocytes induce dysfunction of MIN6 insulin-secreting cells via multiple pathways mediated by secretory factors in a co-culture system. Endocrine, 31 (1), 52-60. doi: 10.1007/s12020-007-0001-3
Roh, Sang-Gun, Doconto, Maria, Feng, Dan Dan and Chen, Chen (2006). Differential regulation of GHRH-receptor and GHS-receptor expression by long-term in vitro treatment of ovine pituitary cells with GHRP-2 and GHRH. Endocrine, 30 (1), 55-62. doi: 10.1385/ENDO:30:1:55
Zhao, Yu-Feng, Feng, Dan Dan and Chen, Chen (2006). Contribution of adipocyte-derived factors to beta-cell dysfunction in diabetes. International Journal of Biochemistry & Cell Biology, 38 (5-6), 804-819. doi: 10.1016/j.biocel.2005.11.008
Feng, Dan Dan, Luo, Ziqiang, Roh, Sang-gun, Hernandez, Maria, Tawadros, Neveen, Keating, Damien J and Chen ,Chen (2006). Reduction in Voltage-Gated K+ Currents in Primary Cultured Rat Pancreatic ß-Cells by Linoleic Acids. Erdocrinology, 147 (2), 674-682. doi: 10.1210/en.2005-0225
Cao, Ji-Min, Ong, Huy and Chen, Chen (2006). Effects of ghrelin and synthetic GH secretagogues on the cardiovascular system. Trends in endocrinology and metabolism, 17 (1), 13-18. doi: 10.1016/j.tem.2005.11.004
Keating, Damien J., Chen, Chen and Pritchard, Melanie A. (2006). Alzheimer's disease and endocytic dysfunction: Clues from the Down syndrome-related proteins, DSCR1 and ITSN1. Ageing research reviews, 5 (4), 388-401. doi: 10.1016/j.arr.2005.11.001
Hong, Yeon-Hee, Nishimura, Yukihiko, Hishikawa, Daisuke, Tsuzuki, Hiroaki, Miyahara, Hisae, Gotoh, Chizu, Choi, Ki-Choon, Feng, Dan Dan, Chen Chen, Lee, Hong-Gu, Katoh, Kazuo, Roh, Sang-Gun and Sasaki, Shinichi (2005). Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology, 146 (12), 5092-5099. doi: 10.1210/en.2005-0545
Feng Han, Xue, Long Zhu, Yun, Hernandez, Maria, Keating, Damien J. and Chen Chen (2005). Ghrelin reduces voltage-gated potassium currents in GH3 cells via cyclic GMP pathways. Endocrine, 28 (2), 217-224. doi: 10.1385/ENDO:28:2:217
Yang, Seung-Kwon, Parkington, Helena C., Blake, Allan D., Keating, Damien J. and Chen, Chen (2005). Somatostatin increases voltage-gated K+ currents in GH3 cells through activation of multiple somatostatin receptors. Endocrinology, 146 (11), 4975-4984. doi: 10.1210/en.2005-0696
Xu, Xiang-Bin, Pang, Jin-Jiang, Cao, Ji-Min, Ni, Chao, Xu, Rong-Kun, Yu ,Xiao-Xia, Peng, Xiao-Zhong, Yu, Xiao-Xia, Guo, Shu, Chen, Meng-Chin and Chen, Chen (2005). GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure. American Journal of Physiology- Heart And Circulatory Physiology, 289 (4), H1643-H1651. doi: 10.1152/ajpheart.01042.2004
Ishiwata, H, Katoh, K, Chen, C, Yonezawa, T, Sasaki, Y and Obara, Y (2005). Suppressing actions of butyrate on growth hormone (GH) secretion induced by GH-releasing hormone in rat anterior pituitary cells. General and Comparative Endocrinology, 143 (3), 222-230. doi: 10.1016/j.ygcen.2005.03.015
Keating, Damien J and Chen, Chen (2005). Activin A stimulates catecholamine secretion from rat adrenal chromaffin cells: A new physiological mechanism. Journal of Endocrinology, 186 (2), R1-R5. doi: 10.1677/joe.1.06301
Zhao, Yu-Feng, Keating, Damien J, Hernandez, Maria, Feng, Dan Dan, Zhu, Yulong and Chen, Chen (2005). Long-term inhibition of protein tyrosine kinase impairs electrophysiologic activity and a rapid component of exocytosis in pancreatic beta cells. Journal of Molecular Endocrinology, 35 (1), 49-59. doi: 10.1677/jme.1.01779
Yan, M., Jones, M. E. E., Hernandez, M., Dongling, L, Simpson, E. R. and Chen, C. (2005). Oestrogen Replacement in Vivo Rescues the Dysfunction of Pituitary Somatotropes in Ovariectomised Aromatase Knockout Mice. Neuroendocrinology, 81 (3), 158-166. doi: 10.1159/000086864
Xue-feng, H., Yun-Long, Z. and Chen, C. (2005). Ghrelin on the role of membrane potential in GH3 cells. Journal of Rehabilitation Theory and Practice, 11, 826-829.
Katoh, K, Matsuda, A, Ishigami, A, Yonekura, S, Ishiwata, H, Chen, C and Obara, Y (2004). Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells. Cell Biology International, 28 (6), 463-469. doi: 10.1016/j.cellbi.2004.03.016
Zhao, Y. F., Zhu, Y. L. and Chen, C. (2004). 3T3-L1 adipocytes reduces Kir6.2 channel expression in MIN6 insulin-secreting cells in vitro. Sheng li xue bao (Acta physiologica Sinica), 56 (2), 253-257.
Pang, J., Xu, Rong-Kun, Xu, Xiang-Bin, Cao, Ji-Min, Ni, Chao, Zhu, Wen-Ling, Asotra, Kamlesh, Chen, Meng-Chin, and Chen, C. (2004). Hexarelin Protects Rat Cardiomyocytes from Angiotensin II-induced Apoptosis in Vitro. American Journal of Physiology- Heart And Circulatory Physiology, 286 (3), 1063-1069. doi: 10.1152/ajpheart.00648.2003
Yan, Ming, Jones, Margaret E. E., Hernandez, Maria, Liu, Dongling, Simpson, Evan R. and Chen Chen (2004). Functional modification of pituitary somatotropes in the aromatase knockout mouse and the effect of estrogen replacement. Endocrinology, 145 (2), 604-612. doi: 10.1210/en.2003-0646
Yan, M., Hernandez, M., Xu, R. and Chen, C. (2004). Effect of GHRH and GHRP-2 Treatment in Vitro on GH Secretion and Levels of GH, Pituitary Transcription Factor-1, GHRH-receptor, GH-secretagogue-receptor and Somatostatin Receptor mRNAs in Ovine Pituitary Cells. European Journal of Endocrinology, 150 (2), 235-242. doi: 10.1530/eje.0.1500235
Zhao, Yu-Feng, Xu, Ruwei, Hernandez, Maria, Zhu, Yunlong and Chen Chen (2003). Distinct Intracellular Ca2+ Response to Extracellular Adenosine Triphosphate in Pancreatic -Cells in Rats and Mice. Endocrine, 22 (3), 185-192. doi: 10.1385/ENDO:22:3:185
Xu, Xiang-Bin, Cao, Ji-Min, Pang, Jing-Jiang, Xu, Rong-Kun, Ni, Chao, Zhu, Wen-Ling, Asotra, Kamlesh, Chen, Meng-Chin and Chen Chen (2003). The Positive Inotropic and Calcium-Mobilizing Effects of Growth Hormone-Releasing Peptides on Rat Heart. Endocrinology, 144 (11), 5050-5057. doi: 10.1210/en.2003-0025
Chen Chen and Xu, Ruwei (2003). The in Vitro Regulation of Growth Hormone Secretion by Orexins. Endocrine, 22 (1), 57-66. doi: 10.1385/ENDO:22:1:57
Choi, Kichoon, Roh, Sang-Gun, Hong, Yeon-Hee, Shrestha, Yogendra B, Hishikawa, Daisuke, Chen Chen, Kojima, Masayasu, Kangawa, Kenji and Sasaki, Shin-Ichi (2003). The Role of Ghrelin and Growth Hormone Secretagogues Receptor on Rat Adipogenesis. Endocrinology, 144 (3), 754-759. doi: 10.1210/en.2002-220783
Xu, Ruwei, Roh, Sang-Gun, Gong, Changhong, Hernandez, Maria, Ueta, Yoichi and Chen, Chen (2002). Orexin-B Augments Voltage-Gated L-Type Ca2+ Current via Protein Kinase C-Mediated Signalling Pathway in Ovine Somatotropes.. Neuroendocrinology, 77 (3), 141-152. doi: 10.1159/000069507
Yan, Ming, Liua, Dong Ling, Chuaa, Yeow Leng, Chen, Chen and Lim, Yean Leng (2002). Tyrosine kinase inhibitors suppress α1-adrenoceptor mediated contraction in human radial, internal mammary arteries and saphenous vein. Neuroscience letters, 333 (3), 171-174. doi: 10.1016/S0304-3940(02)00877-7
Chen, Chen (2002). The Effect of Two-Day Treatment of Primary Cultured Ovine Somatotropes with GHRP-2 on Membrane Voltage-Gated K+ Currents. Endocrinology, 143 (7), 2659-2663. doi: 10.1210/en.143.7.2659
Xu, Ruwei, Wang, Qinling, Yan, Ming, Hernandez, Maria, Gong, Chang-Hong, Boon, Wah-Chin, Murata, Yoko, Ueta, Yoichi and Chen, Chen (2002). Orexin-A Augments Voltage-Gated Ca2 Currents and Synergistically Increases Growth Hormone (GH) Secretion with GH-Releasing Hormone in Primary Cultured Ovine Somatotropes. Endocrinology, 143 (12), 4609-4619. doi: 10.1210/en.2002-220506
Liu, Dong Ling, Yan, Ming, Chua, Yeow Leng, Chen, Chen and Lim, Yean Leng (2002). Effects Of Molybdenum, Silicon And Nickel On α1-Adrenoceptor-Induced Constriction Of Rat Isolated Aorta. Clinical and Experimental Pharmacology and Physiology, 29 (5-6), 395-398. doi: 10.1046/j.1440-1681.2002.03674.x
Roh, Sang-Gun, Chen, Chen, Choi, Ki-Choon, Shrestha, Yogendra and Sasaki, Shin-Ichi (2002). Is GHRH Receptor Essential to GHRP-2-Induced GH Secretion in Primary Cultured Rat Pituitary Cells?. Endocrinology, 143 (5), 1964-1967. doi: 10.1210/en.143.5.1964
Xu, Ruwei, Zhao, Yufeng and Chen, Chen (2002). Growth hormone-releasing peptide-2 reduces inward rectifying K+ currents via a PKA-cAMP-mediated signalling pathway in ovine somatotropes. The journal of physiology, 545 (2), 421-433. doi: 10.1113/jphysiol.2002.030916
Wallace, Damian J, Chen, Chen and Marley, Philip D (2002). Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current. The journal of physiology, 540 (3), 921-939. doi: 10.1113/jphysiol.2001.013370
Chen, Chen (2002). Ion channels and intracellular signalling systems involved in the action of hypothalamic GH releasing and inhibitory hormones. Fudan Lectures in Neurobiology, 18, 63-78.
Chen, Chen (2002). Discovery, progress and future of growth hormone releasing peptides. Basic medical sciences and clinics, 22, 1-5.
Roh, SG, Nie, GY, Loneragan, K, Gertler, A and Chen, C (2001). Direct modification of somatotrope function by long-term leptin treatment of primary cultured ovine pituitary cells. Endocrinology, 142 (12), 5167-5171. doi: 10.1210/en.142.12.5167
Chen, C (2001). Multiple intracellular signallings involved in regulation of ion channels by GH releasing or inhibitory hormones in pituitary somatotropes. Progress in Natural Science, 11 (3), 161-172.
Chen, Chen (2001). Multiple intracellular signallings involved in regulation of ion channels by GH releasing or inhibitory hormones in pituitary somatotropes. Progress in Natural Science, 11 (3), 170-172.
Chen, C., Roh, S. G., Nie, G. Y., Loneragan, K., Xu, R. W., Ruan, M., Clarke, I. J., Goding, J. W. and Gertler, A. (2001). The in vitro effect of leptin on growth hormone secretion from primary cultured ovine somatotrophs. Endocrine, 14 (1), 73-78.
Chen, C, Xu, RW, Clarke, IJ, Ruan, M, Loneragan, K and Roh, SG (2000). Diverse intracellular signalling systems used by growth hormone-releasing hormone in regulating voltage-gated Ca2+ or K+ channels in pituitary somatotropes. Immunology and Cell Biology, 78 (4), 356-368. doi: 10.1046/j.1440-1711.2000.00917.x
Ishiwata, H, Nagano, M, Sasaki, Y, Chen, C and Katoh, K (2000). Short-chain fatty acids inhibit the release and content of growth hormone in anterior pituitary cells of the goat. General and Comparative Endocrinology, 118 (3), 400-406. doi: 10.1006/gcen.2000.7468
Chen, C (2000). Growth hormone secretagogue actions on the pituitary gland: Multiple receptors for multiple ligands?. Clinical and Experimental Pharmacology and Physiology, 27 (5-6), 323-329. doi: 10.1046/j.1440-1681.2000.03258.x
Xu, R., Clarke, I.J., Chen, S. and Chen, C. (2000). Growth hormone-releasing hormone decreases voltage-gated potassium currents in GH4C1 cells. Journal of Neuroendocrinology, 12 (2), 147-157. doi: 10.1046/j.1365-2826.2000.00430.x
Xu, RW, Roh, SG, Loneragan, K, Pullar, M and Chen, C (1999). Human GHRH reduces voltage-gated K+ currents via a non-cAMP-dependent but PKC-mediated pathway in human GH adenoma cells. Journal of Physiology-London, 520 (3), 697-707. doi: 10.1111/j.1469-7793.1999.00697.x
Cowley, MA, Chen, C and Clarke, IJ (1999). Estrogen transiently increases delayed rectifier, voltage-dependent potassium currents in ovine gonadotropes. Neuroendocrinology, 69 (4), 254-260. doi: 10.1159/000054426
Chen, Chen (1999). A highly specific approach for studying intracellular signalling and membrane ion channels. Chinese Physiological Communication, 18, 32-34.
Roh, SG, Clarke, IJ, Xu, RW, Goding, JW, Loneragan, K and Chen, C (1998). The in vitro effect of leptin on basal and growth hormone-releasing hormone-stimulated growth hormone secretion from the ovine pituitary gland. Neuroendocrinology, 68 (6), 361-364. doi: 10.1159/000054385
Chen, C, Farnworth, P, Petersenn, S, Musgrave, I, Canny, BJ and Clarke, IJ (1998). Growth hormone-releasing peptide-2 (GHRP-2) does not act via the human growth hormone-releasing factor receptor in GC cells. Endocrine, 9 (1), 71-77. doi: 10.1385/ENDO:9:1:71
Chen, C (1998). G(i-3) protein mediates the increase in voltage-gated K+ currents by somatostatin on cultured ovine somatotrophs. American Journal of Physiology-Endocrinology and Metabolism, 275 (2), E278-E284.
Chen, C, Pullar, M, Loneragan, K, Zhang, J and Clarke, IJ (1998). Effect of growth hormone-releasing peptide-2 (GHRP-2) and GH-releasing hormone (GHRH) on the cAMP levels and GH release from cultured acromegalic tumours. Journal of Neuroendocrinology, 10 (6), 473-480. doi: 10.1046/j.1365-2826.1998.00233.x
Wu, D, Clarke, IJ and Chen, C (1997). The role of protein kinase C in GH secretion induced by GH-releasing factor and GH-releasing peptides in cultured ovine somatotrophs. Journal of Endocrinology, 154 (2), 219-230. doi: 10.1677/joe.0.1540219
Katoh, Kazuo and Chen, Chen (1997). The research progress in synthetic growth hormone-releasing secretagogues. Agricultural Research, 51, 67-71.
Chen, C., Wu, D., Bowers, C. Y., Deghenghi, R., Melmed, S. and Clarke, I. J. (1997). P-077. Evidence that ghrps act via specific, non-grf receptors. Endocrinology and Metabolism, Supplement, 4 (A)
Chen, C, Wu, D and Clarke, IJ (1996). Commentary - Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs. Journal of Endocrinology, 148 (3), 381-386. doi: 10.1677/joe.0.1480381
Wu, D, Chen, C, Zhang, J, Bowers, CY and Clarke, IJ (1996). The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs. Journal of Endocrinology, 148 (2), 197-205. doi: 10.1677/joe.0.1480197
Chen, C and Clarke, IJ (1996). G(o)-2 protein mediates the reduction in Ca2+ currents by somatostatin in cultured ovine somatotrophs. Journal of Physiology-London, 491 (1), 21-29. doi: 10.1113/jphysiol.1996.sp021193
Katoh, Kazuo, Chen, Chen and Engler, Dennis (1996). Effects of GHRP on GH release and intracellular calcium concentration in primary cultured ovine anterior pituitary cells. Journal of Reproduction and Development, 42 (suppl), 106-108.
Heyward, PM, Chen, C and Clarke, IJ (1995). Inward Membrane Currents and Electrophysiological Responses to Gnrh in Ovine Gonadotropes. Neuroendocrinology, 61 (6), 609-621. doi: 10.1159/000126887
Chen, C and Clarke, IJ (1995). Effects of Growth Hormone-Releasing Peptide-2 (ghrp-2) On Membrane Ca2+ Permeability in Cultured Ovine Somatotrophs. Journal of Neuroendocrinology, 7 (3), 179-186. doi: 10.1111/j.1365-2826.1995.tb00745.x
Chen, C and Clarke, IJ (1995). Modulation of Ca2+ Influx in the Ovine Somatotroph by Growth Hormone-Releasing Factor. American Journal of Physiology-Endocrinology and Metabolism, 268 (2), E204-E212.
Chen, C, Vincent, JD and Clarke, IJ (1994). Ion Channels and the Signal-Transduction Pathways in the Regulation of Growth-Hormone Secretion. Trends in Endocrinology and Metabolism, 5 (6), 227-233. doi: 10.1016/1043-2760(94)P3080-Q
Wu, DX, Chen, C, Katoh, K, Zhang, J and Clarke, IJ (1994). The Effect of Gh-Releasing Peptide-2 (ghrp-2 or Kp 102) On Gh Secretion From Primary Cultured Ovine Pituitary-Cells Can Be Abolished by a Specific Gh-Releasing Factor (grf) Receptor Antagonist. Journal of Endocrinology, 140 (2), R9-R13. doi: 10.1677/joe.0.140R009
Chen, C, Heyward, P, Zhang, J, Wu, DX and Clarke, IJ (1994). Voltage-Dependent Potassium Currents in Ovine Somatotrophs and Their Function in Growth-Hormone Secretion. Neuroendocrinology, 59 (1), 1-9. doi: 10.1159/000126631
Heyward, PM, Chen, C and Clarke, IJ (1993). Gonadotropin-Releasing-Hormone Modifies Action-Potential Generation in Sheep Pars-Distalis Gonadotropes. Neuroendocrinology, 58 (6), 646-654. doi: 10.1159/000126605
Wagoner, PK, Chen, C, Worley, JF, Dukes, ID and Oxford, GS (1993). Amylin Modulates Beta-Cell Glucose Sensing Via Effects On Stimulus-Secretion Coupling. Proceedings of the National Academy of Sciences of the United States of America, 90 (19), 9145-9149. doi: 10.1073/pnas.90.19.9145
Chen, C, Zhang, J, Israel, JM, Clarke, IJ and Vincent, JD (1993). Mechanism of the Prolactin Rebound After Dopamine Withdrawal in Rat Pituitary-Cells. American Journal of Physiology, 265 (1), E145-E152.