The Vukovic laboratory investigates how brain function is  sculpted and influenced by the immune system. Specifically, we examine the role of brain’s main resident immune cell population (i.e. microglia), as well as various peripheral immune cells, on learning and memory in mice. We are interested in defining the contribution of immune cells to such higher cognitive tasks, including for neuroinflammatory conditions where learning and memory deficits can occur, e.g. following traumatic brain injury, cancer treatment, and ageing. We have established an array of genetic and pharmacological tools alongside robust behavioural assays to directly probe the function of these immune cells in both the healthy and diseased brain. The ultimate goal of our work is to link cellular and molecular events to altered behaviour, and to harness the brain’s intrinsic regenerative potential for stimulating optimal cognitive function.

A neuroimmunologist, Dr Vukovic received her PhD in 2008 from The University of Western Australia after working on the repair of injured nerve cell connections. She joined QBI in 2009 to work in Professor Perry Bartlett’s laboratory as a Postdoctoral Research Fellow, before being awarded a Queensland Government Smart Futures Fellowship to continue her research into the importance of adult neurogenesis for behaviour and how microglia influence this process in ageing. Dr Vukovic demonstrated that microglia can exert a dual and opposing influence over adult neurogenesis (the birth of new neurons) in the hippocampus under different physiological conditions, namely exercise and ageing, and that signalling through the chemokine receptor, CX3CR1, critically contributes towards this (Vukovic et al., 2012, J Neurosci). Dr Vukovic also generated novel evidence that ongoing neurogenesis in the adult hippocampus is critical for new learning but does not play a role in memory recall (Vukovic et al., 2013, J Neurosci).

Dr Vukovic was awarded an ARC Discovery Early Career Researcher Award (2015-2018) and was jointly appointed as a group leader by the UQ School of Biomedical Sciences (SBMS) and QBI in 2015. She heads the Neuroimmunology and Cognition team investigating the interactions between the brain and the immune system in health and disease.

Currently the group is working on three main projects:

  1. Identification of microglia-derived molecules that support neuronal survival and stimulate neural stem/progenitor cell expansion
  2. Characterisation of immune cell contribution to changes in neuronal connectivity
  3. Immune cell responses to cancer treatment, and their effect on learning and memory

Group Head

Ortega FJ, Vukovic J, Rodríguez MJ, Bartlett PF (2014) Blockade of microglial KATP channels abrogates suppression of inflammatory-mediated inhibition of neural precursor cells. Glia 62: 247-258

Vukovic J, Borlikova GG, Ruitenberg MJ, Robinson GJ, Sullivan RKP, Walker TL, Bartlett PF (2013) Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering. The Journal of Neuroscience 33: 6603-6613

Vukovic J, Bedin AS, Bartlett PF, Osborne GW (2013) A novel fluorescent reporter CDy1 enriches for neural stem cells derived from the murine brain.Stem Cells and Development 22: 2341-2345

Vukovic J, Colditz M, Blackmore DG, Ruitenberg MJ, Bartlett PF (2012) Microglia modulate hippocampal neural precursor activity in response to exercise and ageing. The Journal of Neuroscience 32: 6435-6443

Blackmore DG, Vukovic J, Waters MJ, Bartlett PF (2012) GH mediates exercise-dependent activation of SVZ neural precursor cells in aged mice. PloS One 7: e49912

Walker TL, Vukovic J, Koudijs MM, Blackmore DG, Mackay EW, Sykes AM, Overall RW, Hamlin AS, Bartlett PF. (2012) Prolactin stimulates precursor cells in the adult mouse hippocampus. PloS One 7: e44371

Vukovic J, Blackmore DG, Jhaveri D, Bartlett PF (2011) Activation of neural precursors in the adult neurogenic niches. Neurochemistry International 59: 341-346

Honours:

The following Honours projects are currently available:

  • The role of microglia in regulating neurogenesis and learning/memory
  • Characterisation of hippocampal neurons important for spatial learning

Postgraduate:

PhD scholarship available to join the Vukovic lab: https://graduate-school.uq.edu.au/project-scholarships 

 

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