Pagan Group - Targeted protein degradation

Our research seeks to elucidate the cellular and biochemical mechanisms by which the ubiquitin proteasome system (UPS) regulates cellular homeostasis. We use interdisciplinary approaches incorporating biochemistry, proteomics, molecular and cell biology to understand how individual ubiquitin ligase subunits specifically target their substrates. We focus particularly on understanding the regulation of centrosomes, microtubules and mitochondria. Corrupting the regulatory pathways that coordinate these organelles can have major health consequences and is the driving force behind many diseases, including cancers and neurodegenerative disorders.

We have a number of exciting projects addressing the regulation of cellular homeostasis by the ubiquitin proteasome system. 

  1. Centrosomes are important organelles that play roles in cell signaling, microtubule-dependent trafficking and chromosome segregation. Our lab has ongoing projects related to the regulation of centrosome function by the ubiquitin proteasome system.  
  2. Mitochondrial function is a critical determinant of cell viability. We are exploring the role of the ubiquitin proteasome system in regulating mitochondrial quality control pathways. 
  3. We are seeking to develop novel ways to reactivate defective ubiquitin ligase signalling pathways in cancers.

We use a wide range of cell biology and biochemical techniques to study these questions, making our lab an ideal place to gain research experience for students, and a home for collaborators on projects of suitable interest. Our projects adopt the latest gene-editing, protein purification and mass spectrometry approaches.

Group Head

PhD students

We are currently recruiting a PhD student. Applicants with relevant expertise and a keen interest in cell biology, biochemistry, and/or chemical biology, should contact j.pagan@uq.edu.au. International applicants are also encouraged to apply.

Proposals

We are always interested to hear from highly motivated and talented researchers with an interest in our research. We welcome proposals from postdocs, visiting sabbatical researchers and collaborators who believe they can contribute to our research.

Please tell us about yourself and send a resume to Dr Julia Pagan at j.pagan@uq.edu.au