Dr Cassy Spiller
Research Fellow
School of Biomedical Sciences
Cassy is part of the Bowles group which studies developmental reproductive biology.
Book Chapters
Burnet, Guillaume, Bowles, Josephine and Spiller, Cassy M. (2023). Isolation and culture techniques for fetal mouse germ cells. Germline stem cells: methods and protocols. (pp. 221-231) edited by Michael Buszczak. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-3259-8_13
Spiller, Cassy and Bowles, Josephine (2019). Sexually dimorphic germ cell identity in mammals. Sex determination in vertebrates. (pp. 253-288) Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.ctdb.2019.01.011
Spiller, Cassy M., Burnet, Guillaume and Bowles, Josephine (2017). Mouse fetal germ cell isolation and culture techniques. Germline stem cells. (pp. 173-183) edited by Michael Buszczak. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-4017-2_13
Spiller, Cassy M. and Koopman, Peter (2011). Cell cycle control of germ cell differentiation. Cell cycle in development. (pp. 269-308) edited by Jacek Z. Kubiak. New York, United States: Springer. doi: 10.1007/978-3-642-19065-0
Combes, Alexander, Spiller, Cassy and Koopman, Peter (2010). Sex Determination and Gonadal Development. Oogenesis: The Universal Process. (pp. 27-79) Chichester, UK: John Wiley and Sons. doi: 10.1002/9780470687970.ch2
Combes, Alexamder, Spiller. Cassy and Koopman, Peter (2010). Sex determination and Gonadal Development. Oogenesis : The universal process. (pp. 27-80) edited by Marie-Hélène Verlhac and Anne Villeneuve. Chichester, UK: Wiley-Blackwell.
Journal Articles
Draskau, Monica K., Strand, Ida W., Davila, Raul, Ballegaard, Anne-Sofie R., Pedersen, Mikael, Ramhøj, Louise, Rising, Sofie, Tran, Kieu-mi, Axelstad, Marta, Bowles, Josephine, Rosenmai, Anna K., Spiller, Cassy M. and Svingen, Terje (2024). Perinatal exposure to environmental chemicals that disrupt thyroid function can perturb testis development. Environmental Pollution, 363 125117, 125117. doi: 10.1016/j.envpol.2024.125117
Burnet, Guillaume, Feng, Chun‐Wei Allen, Cheung, Ka Man Fiona, Bowles, Josephine and Spiller, Cassy M. (2023). Generation and characterization of a
Ddx4‐iCre
transgenic line for deletion in the germline beginning at genital ridge colonization. genesis, 61 (1-2) e23511, e23511. doi: 10.1002/dvg.23511
Spiller, Cassy and Bowles, Josephine (2022). Instructing mouse germ cells to adopt a female fate. Sexual Development, 16 (5-6), 1-13. doi: 10.1159/000523763
Davila, Raul Ayala, Spiller, Cassy, Harkins, Danyon, Harvey, Tracey, Jordan, Philip W., Gronostajski, Richard M., Piper, Michael and Bowles, Josephine (2022). Deletion of NFIX results in defective progression through meiosis within the mouse testis. Biology of Reproduction, 106 (6), 1191-1205. doi: 10.1093/biolre/ioac049
Kam Draskau, Monica, Ravn Ballegaard, Anne-Sofie, Ramhøj, Louise, Bowles, Josephine, Svingen, Terje and Spiller, Cassy M. (2022). AOP Key Event Relationship report: Linking decreased retinoic acid levels with disrupted meiosis in developing oocytes. Current Research in Toxicology, 3 100069, 1-8. doi: 10.1016/j.crtox.2022.100069
Feng, Chun-Wei, Burnet, Guillaume, Spiller, Cassy M., Cheung, Fiona Ka Man, Chawengsaksophak, Kallayanee, Koopman, Peter and Bowles, Josephine (2021). Identification of regulatory elements required for Stra8 expression, in fetal ovarian germ cells of the mouse. Development, 148 (5) dev194977, 1-13. doi: 10.1242/dev.194977
Spiller, Cassy M., Lobo, João, Boellaard, Willem P. A., Gillis, Ad J. M., Bowles, Josephine and Looijenga, Leendert H. J. (2020). CRIPTO and miR-371a-3p are serum biomarkers of testicular germ cell tumors and are detected in seminal plasma from azoospermic males. Cancers, 12 (3) 760, 760. doi: 10.3390/cancers12030760
Draskau, Monica Kam, Spiller, Cassy M., Boberg, Julie, Bowles, Josephine and Svingen, Terje (2020). Developmental biology meets toxicology: contributing reproductive mechanisms to build adverse outcome pathways. Molecular Human Reproduction, 26 (2), 111-116. doi: 10.1093/molehr/gaaa001
Bowles, Josephine, Feng, Chun-Wei, Ineson, Jessica, Miles, Kim, Spiller, Cassy M., Harley, Vincent R., Sinclair, Andrew H. and Koopman, Peter (2018). Retinoic acid antagonizes testis development in mice. Cell Reports, 24 (5), 1330-1341. doi: 10.1016/j.celrep.2018.06.111
Zhao, Liang, Wang, Chenwei, Lehman, Melanie L., He, Mingyu, An, Jiyuan, Svingen, Terje, Spiller, Cassy M., Ng, Ee Ting, Nelson, Colleen C. and Koopman, Peter (2018). Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination. Molecular and Cellular Endocrinology, 478, 84-96. doi: 10.1016/j.mce.2018.07.010
Feng, Chun-Wei Allen, Spiller, Cassy, Merriner, Donna J., O'Bryan, Moira K., Bowles, Josephine and Koopman, Peter (2017). SOX30 is required for male fertility in mice. Scientific Reports, 7 (1) 17619, 1-12. doi: 10.1038/s41598-017-17854-5
Spiller, Cassy, Koopman, Peter and Bowles, Josephine (2017). Sex Determination in the Mammalian Germline. Annual Review of Genetics, 51 (1), 265-285. doi: 10.1146/annurev-genet-120215-035449
Spiller, Cassy, Burnet, Guillaume and Bowles, Josephine (2017). Regulation of fetal male germ cell development by members of the TGFβ superfamily. Stem cell research, 24, 174-180. doi: 10.1016/j.scr.2017.07.016
Spiller, Cassy M. and Bowles, Josephine (2017). Germ cell neoplasia in situ: the precursor cell for invasive germ cell tumors of the testis. International Journal of Biochemistry & Cell Biology, 86, 22-25. doi: 10.1016/j.bioce1.2017.03.004
Spiller, Cassy M., Wilhelm, Dagmar, Jans, David A., Bowles, Josephine and Koopman, Peter (2017). Mice lacking Hbp1 function are viable and fertile. PLoS One, 12 (1) e0170576, e0170576. doi: 10.1371/journal.pone.0170576
Spiller, Cassy M., Gillis, Ad J. M., Burnet, Guillaume, Stoop, Hans, Koopman, Peter, Bowles, Josephine and Looijenga, Leendert H. J. (2016). Cripto: expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. Molecular Oncology, 10 (4), 526-537. doi: 10.1016/j.molonc.2015.11.003
Bowles, Josephine, Feng, Chun-Wei, Miles, Kim, Ineson, Jessica, Spiller, Cassy and Koopman, Peter (2016). ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries. Nature Communications, 7 (1) 10845, 10845.1-10845.8. doi: 10.1038/ncomms10845
Rios-Rojas, Clarissa, Spiller, Cassy, Bowles, Josephine and Koopman, Peter (2016). Germ cells influence cord formation and leydig cell gene expression during mouse testis development. Developmental Dynamics, 245 (4), 433-444. doi: 10.1002/dvdy.24371
Spiller, Cassy M. and Bowles, Josephine (2015). Sex determination in mammalian germ cells. Asian Journal of Andrology, 17 (3), 427-432. doi: 10.4103/1008-682X.150037
Spiller, Cassy M., Bowles, Josephine and Koopman, Peter (2013). Regulation of germ cell meiosis in the fetal ovary. International Journal of Developmental Biology, 56 (10-12), 779-787. doi: 10.1387/ijdb.120142pk
Spiller, Cassy M., Bowles, Josephine and Koopman, Peter (2013). Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors. International Journal of Developmental Biology, 57 (2-4), 211-219. doi: 10.1387/ijdb.130028pk
Spiller, Cassy M., Feng, Chun-Wei, Jackson, Andrew, Gillis, Ad J. M., Rolland, Antoine D., Looijenga, Leendert H. J., Koopman, Peter and Bowles, Josephine (2012). Endogenous nodal signaling regulates germ cell potency during mammalian testis development. Development, 139 (22), 4123-4132. doi: 10.1242/dev.083006
Chen, Huijun, Palmer, James S., Thaigarajan, Rathi D., Dinger, Marcel E., Frampton, Emmanuelle, Chiu, Hansheng, Schulz, Alexandra, Spiller, Cassy, Grimmond, Sean M., Little, Melissa H., Koopman, Peter A. and Wilhelm, Ingrid D. (2012). Identification of novel markers of mouse fetal ovary development. PLoS One, 7 (7) e41683, e41683.1-e41683.15. doi: 10.1371/journal.pone.0041683
Chawengsaksophak, Kallayanee, Svingen, Terje, Ng, Ee Ting, Epp, Trevor, Spiller, Cassy M., Clark, Charlotte, Cooper, Helen and Koopman, Peter (2012). Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biology of Reproduction, 86 (1) 4, 1-12. doi: 10.1095/biolreprod.111.095232
Bowles, Josephine, Feng, Chun-Wei, Spiller, Cassy, Davidson, Tara-Lynne, Jackson, Andrew and Koopman, Peter (2010). FGF9 suppresses meiosis and promotes male germ cell fate in mice. Developmental Cell, 19 (3), 440-449. doi: 10.1016/j.devcel.2010.08.010
Spiller, Cassy M., Wilhelm, Dagmar and Koopman, Peter (2010). Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice. Biology of Reproduction, 82 (2), 433-443. doi: 10.1095/biolreprod.109.078691
Combes, Alexander N., Spiller, Cassy M., Harley, Vincent R., Sinclair, Andrew H., Dunwoodie, Sally L., Wilhelm, Dagmar and Koopman, Peter (2010). Gonadal defects in Cited2 -mutant mice indicate a role for SF1 in both testis and ovary differentiation. International Journal of Developmental Biology, 54 (4), 683-689. doi: 10.1387/ijdb.092920ac
Spiller, Cassy, Wilhelm, Dagmar and Koopman, Peter (2009). Cell cycle analysis of fetal germ cells during sex differentiation in mice. Biology of The Cell, 101 (10), 587-598. doi: 10.1042/BC20090021
Svingen, T, Spiller, C. M., Kashimada, K, Harley, V. R. and Koopman, P (2009). Identification of suitable normalizing genes for quantitative real-time RT-PCR analysis of gene expression in fetal mouse gonads. SEXUAL DEVELOPMENT, 3 (4), 194-204. doi: 10.1159/000228720
Nixon, Brett, Paul, Jonathan W., Spiller, Cassy M., Attwell-Heap, Abigail G., Ashman, Leonie K. and Aitken, John (2005). Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa. Journal of Cell Science, 118 (20), 4865-4877. doi: 10.1242/jcs.02604
Thesis
Cassy Spiller (2009). Investigating Sex Specific Cell Cycle Regulation in Fetal Germ Cells. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland.