Honorary Professor Vicki Whitehall

Ramsay, Robert G., Whitehall, Vicki and Flood, Michael P. (2023). Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer. Growth Factors, 41 (4), 179-191. doi: 10.1080/08977194.2023.2227274

Tria, Simon Manuel, Burge, Matthew E. and Whitehall, Vicki L. J. (2023). The therapeutic landscape for KRAS-Mutated colorectal cancers. Cancers, 15 (8) 2375, 1-25. doi: 10.3390/cancers15082375

Su, Chang, Olsen, Kelly A., Bond, Catherine E. and Whitehall, Vicki L. J. (2023). The efficacy of using patient-derived organoids to predict treatment response in colorectal cancer. Cancers, 15 (3) 805, 1-16. doi: 10.3390/cancers15030805

Fennell, Lochlan J., Hartel, Gunter, McKeone, Diane M., Bond, Catherine E., Kane, Alexandra, Leggett, Barbara A., Patch, Ann-Marie and Whitehall, Vicki L.J. (2022). Comparative analysis of Illumina Mouse Methylation BeadChip and reduced-representation bisulfite sequencing for routine DNA methylation analysis. Cell Reports Methods, 2 (11) 100323, 1-14. doi: 10.1016/j.crmeth.2022.100323

Turpín‐sevilla, María Del Carmen, Pérez‐sanz, Fernando, García‐solano, José, Sebastián‐león, Patricia, Trujillo‐santos, Javier, Carbonell, Pablo, Estrada, Eduardo, Tuomisto, Anne, Herruzo, Irene, Fennell, Lochlan J., Mäkinen, Markus J., Rodríguez‐braun, Edith, Whitehall, Vicki L. J., Conesa, Ana and Conesa‐zamora, Pablo (2021). Global methylome scores correlate with histological subtypes of colorectal carcinoma and show different associations with common clinical and molecular features. Cancers, 13 (20) 5165, 5165. doi: 10.3390/cancers13205165

Fennell, Lochlan, Kane, Alexandra, Liu, Cheng, McKeone, Diane, Hartel, Gunter, Su, Chang, Bond, Catherine, Bettington, Mark, Leggett, Barbara and Whitehall, Vicki (2021). Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium. Gut, 71 (6) 322166, 1127-1140. doi: 10.1136/gutjnl-2020-322166

Borowsky, Jennifer, Haruki, Koichiro, Lau, Mai Chan, Costa, Andressa Dias, Vayrynen, Juha P., Ugai, Tomotaka, Arima, Kota, Da Silva, Annacarolina, Felt, Kristen D., Zhao, Melissa, Gurjao, Carino, Twombly, Tyler S., Fujiyoshi, Kenji, Vayrynen, Sara A., Hamada, Tsuyoshi, Mima, Kosuke, Bullman, Susan, Harrison, Tabitha A., Phipps, Amanda I., Peters, Ulrike, Ng, Kimmie, Meyerhardt, Jeffrey A., Song, Mingyang, Giovannucci, Edward L., Wu, Kana, Zhang, Xuehong, Freeman, Gordon J., Huttenhower, Curtis, Garrett, Wendy S. ... Ogino, Shuji (2021). Association of Fusobacterium nucleatum with specific T-cell subsets in the colorectal carcinoma microenvironment. Clinical Cancer Research, 27 (10), 2816-2826. doi: 10.1158/1078-0432.CCR-20-4009

Kane, Alexandra M., Liu, Cheng, Fennell, Lochlan J., McKeone, Diane M., Bond, Catherine E., Pollock, Pamela M., Young, Graeme, Leggett, Barbara A. and Whitehall, Vicki L. J. (2021). Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasia. British Journal of Cancer, 124 (11), 1820-1827. doi: 10.1038/s41416-021-01339-4

Kane, Alexandra M., Liu, Cheng, Akhter, Dewan T., McKeone, Diane M., Bell, Craig A., Thurecht, Kristofer J., Leggett, Barbara A. and Whitehall, Vicki L. J. (2021). Curcumin chemoprevention reduces the incidence of Braf mutant colorectal cancer in a preclinical study. Digestive Diseases and Sciences, 66 (12), 4326-4332. doi: 10.1007/s10620-020-06752-y

Cuda, Tahleesa J., Riddell, Andrew D., Liu, Cheng, Whitehall, Vicki L., Borowsky, Jennifer, Wyld, David K., Burge, Matthew E., Ahern, Elizabeth, Griffin, Alison, Lyons, Nicholas J. R., Rose, Stephen E., Clark, David A., Stevenson, Andrew R. L., Hooper, John D., Puttick, Simon and Thomas, Paul A. (2020). PET imaging quantifying Ga-PSMA-11 uptake in metastatic colorectal cancer. The Journal of Nuclear Medicine, 61 (11), 1576-1579. doi: 10.2967/jnumed.119.233312

Kuchel, Anna, Ahern, Elizabeth, Collins, Stephanie, Whitehall, Vicki, Okano, Satomi, Pelecanos, Anita, Wyld, David, Eastgate, Melissa and Burge, Matthew (2020). Trends in epidemiology, treatment and molecular testing of metastatic colorectal cancer in a real‐world multi‐institution cohort study. Asia-Pacific Journal of Clinical Oncology, 17 (1) ajco.13420, 84-93. doi: 10.1111/ajco.13420

Fennell, Lochlan J., Kane, Alexandra, Liu, Cheng, McKeone, Diane, Fernando, Winnie, Su, Chang, Bond, Catherine, Jamieson, Saara, Dumenil, Troy, Patch, Ann-Marie, Kazakoff, Stephen H., Pearson, John V., Waddell, Nicola, Leggett, Barbara and Whitehall, Vicki L. J (2020). APC mutation marks an aggressive subtype of BRAF mutant colorectal cancers. Cancers, 12 (5) 1171, 1-26. doi: 10.3390/cancers12051171

Miller, Gregory C., Liu, Cheng, Bettington, Mark L., Leggett, Barbara, Whitehall, Vicki L.J. and Rosty, Christophe (2020). Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease:. Human Pathology, 97, 19-28. doi: 10.1016/j.humpath.2019.12.005

Kane, Alexandra M., Fennell, Lochlan J., Liu, Cheng, Borowsky, Jennifer, McKeone, Diane M., Bond, Catherine E., Kazakoff, Stephen, Patch, Ann-Marie, Koufariotis, Lambros T., Pearson, John, Waddell, Nicola, Leggett, Barbara A. and Whitehall, Vicki L.J. (2020). Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer. Neoplasia, 22 (2), 120-128. doi: 10.1016/j.neo.2019.12.002

Bettington, Mark, Liu, Cheng, Gill, Anthony, Walker, Neal, Leggett, Barbara, Whitehall, Vicki and Rosty, Christophe (2019). BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with adenomatous dysplasia may represent collision lesions. Histopathology, 75 (1), 81-87. doi: 10.1111/his.13851

Liu, Cheng, Fennell, Lochlan J., Bettington, Mark L., Walker, Neal I., Dwine, Joel, Leggett, Barbara A. and Whitehall, Vicki L. J. (2019). DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas. Clinical Epigenetics, 11 (1) 90, 90. doi: 10.1186/s13148-019-0691-4

Mittal, Deepak, Lepletier, Ailin, Madore, Jason, Aguilera, Amelia Roman, Stannard, Kimberley, Blake, Stephen J., Whitehall, Vicki L. J., Liu, Cheng, Bettington, Mark L., Takeda, Kazuyoshi, Long, Georgina V., Scolyer, Richard A., Lan, Ruth, Siemers, Nathan, Korman, Alan, Teng, Michele W. L., Johnston, Robert J., Dougall, William C. and Smyth, Mark J. (2019). CD96 Is an Immune Checkpoint That Regulates CD8(+) T-cell Antitumor Function. Cancer Immunology Research, 7 (4), 559-571. doi: 10.1158/2326-6066.CIR-18-0637

Atkinson, Caroline J., Kawamata, Futoshi, Ham, Sunyoung, Liu, Cheng, Győrffy, Balázs, Munn, Alan L., Wei, Ming Q., Möller, Andreas, Whitehall, Vicki and Wiegmans, Adrian P. (2019). EGFR and Prion protein promote signaling via FOXO3a-KLF5 resulting in clinical resistance to platinum agents in colorectal cancer. Molecular Oncology, 13 (4), 725-737. doi: 10.1002/1878-0261.12411

Fennell, Lochlan, Dumenil, Troy, Wockner, Leesa, Hartel, Gunter, Nones, Katia, Bond, Catherine, Borowsky, Jennifer, Liu, Cheng, McKeone, Diane, Bowdler, Lisa, Montgomery, Grant, Klein, Kerenaftali, Hoffmann, Isabell, Patch, Ann-Marie, Kazakoff, Stephen, Pearson, John, Waddell, Nicola, Wirapati, Pratyaksha, Lochhead, Paul, Imamura, Yu, Ogino, Shuji, Shao, Renfu, Tejpar, Sabine, Leggett, Barbara and Whitehall, Vicki (2019). Integrative genome-scale DNA methylation analysis of a large and unselected cohort reveals five distinct subtypes of colorectal adenocarcinomas. Cellular and Molecular Gastroenterology and Hepatology, 8 (2), 269-290. doi: 10.1016/j.jcmgh.2019.04.002

Liu, Cheng, Bettington, Mark L., Walker, Neal I., Dwine, Joel, Hartel, Gunter F., Leggett, Barbara A. and Whitehall, Vicki L. J. (2018). CpG island methylation in sessile serrated adenomas increases with age, indicating lower risk of malignancy in young patients. Gastroenterology, 155 (5), 1362-1365. doi: 10.1053/j.gastro.2018.07.012

Bettington, Mark, Rosty, Christophe, Whitehall, Vicki, Leggett, Barbara, McKeone, Diane, Pearson, Sally-Ann and Walker, Neal (2018). A morphological and molecular study of proposed early forms of the traditional serrated adenoma. Histopathology, 73 (6), 1023-1029. doi: 10.1111/his.13714

Bettington, Mark, Brown, Ian, Rosty, Christophe, Walker, Neal, Liu, Cheng, Croese, John, Rahman, Tony, Pearson, Sally-Ann, McKeone, Diane, Leggett, Barbara and Whitehall, Vicki (2018). Sessile serrated adenomas in young patients may have limited risk of malignant progression. Journal of Clinical Gastroenterology, 53 (3), 1-e116. doi: 10.1097/MCG.0000000000001014

Borowsky, Jennifer, Dumenil, Troy, Bettington, Mark, Pearson, Sally-Ann, Bond, Catherine, Fennell, Lochlan, Liu, Cheng, McKeone, Diane, Rosty, Christophe, Brown, Ian, Walker, Neal, Leggett, Barbara and Whitehall, Vicki (2018). The role of APC in WNT pathway activation in serrated neoplasia. Modern Pathology, 31 (3), 495-504. doi: 10.1038/modpathol.2017.150

Bond, Catherine E., Liu, Cheng, Kawamata, Futoshi, McKeone, Diane M., Fernando, Winnie, Jamieson, Saara, Pearson, Sally-Ann, Kane, Alexandra, Woods, Susan L., Lannagan, Tamsin R. M., Somashekar, Roshini, Lee, Young, Dumenil, Troy, Hartel, Gunter, Spring, Kevin J., Borowsky, Jennifer, Fennell, Lochlan, Bettington, Mark, Lee, Jason, Worthley, Daniel L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2018). Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia. Epigenetics, 13 (1), 40-48. doi: 10.1080/15592294.2017.1411446

Fennell, Lochlan J., Jamieson, Saara, McKeone, Diane, Corish, Tracie, Rohdmann, Megan, Furner, Tori, Bettington, Mark, Liu, Cheng, Kawamata, Futoshi, Bond, Catherine, Van De Pols, Jolieke, Leggett, Barbara and Whitehall, Vicki (2018). MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation. BMC Cancer, 18 (1) 35, 1-7. doi: 10.1186/s12885-017-3946-5

Kawamata, Futoshi, Patch, Ann-Marie, Nones, Katia, Bond, Catherine, McKeone, Diane, Pearson, Sally-Ann, Homma, Shigenori, Liu, Cheng, Fennell, Lochlan, Dumenil, Troy, Hartel, Gunter, Kobayasi, Nozomi, Yokoo, Hideki, Fukai, Moto, Nishihara, Hiroshi, Kamiyama, Toshiya, Burge, Matthew E., Karapetis, Christos S., Taketomi, Akinobu, Leggett, Barbara, Waddell, Nicola and Whitehall, Vicki (2018). Copy number profiles of paired primary and metastatic colorectal cancers. Oncotarget, 9 (3), 3394-3405. doi: 10.18632/oncotarget.23277

Bond, Catherine E. and Whitehall, Vicki L. J. (2018). How the BRAF V600E mutation defines a distinct subgroup of colorectal cancer: molecular and clinical implications. Gastroenterology Research and Practice, 2018 9250757, 1-14. doi: 10.1155/2018/9250757

Liu, Cheng, Walker, Neal I., Leggett, Barbara A., Whitehall, Vicki L. J., Bettington, Mark L. and Rosty, Christophe (2017). Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry. Modern Pathology, 30 (12), 1728-1738. doi: 10.1038/modpathol.2017.92

Fennell, Lochlan J. , Clendenning, Mark, McKeone, Diane M. , Jamieson, Saara H., Balachandran, Samanthy, Borowsky, Jennifer, Liu, John, Kawamata, Futoshi, Bond, Catherine E., Rosty, Christophe, Burge, Matthew E., Buchanan, Daniel D., Leggett, Barbara A. and Whitehall, Vicki L. J. (2017). RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers. Familial Cancer, 17 (1), 1-7. doi: 10.1007/s10689-017-0003-0

Liu, Cheng, Mckeone, Diane M., Walker, Neal I., Bettington, Mark L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2017). GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features. Histopathology, 70 (7), 1079-1088. doi: 10.1111/his.13180

Bettington, Mark, Walker, Neal, Rahman, Tony, Vandeleur, Ann, Whitehall, Vicki, Leggett, Barbara and Croese, John (2017). High prevalence of sessile serrated adenomas in contemporary outpatient colonoscopy practice. Internal Medicine Journal, 47 (3), 318-323. doi: 10.1111/imj.13329

Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, McKeone, Diane, Pearson, Sally-Ann, Leggett, Barbara and Whitehall, Vicki (2016). Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma. Gut, 66 (1), 97-106. doi: 10.1136/gutjnl-2015-310456

Bond, Catherine E., McKeone, Diane M., Kalimutho, Murugan, Bettington, Mark L., Pearson, Sally-Ann, Dumenil, Troy D., Wockner, Leesa F., Burge, Matthew, Leggett, Barbara A. and Whitehall, Vicki L. J. (2016). RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis. Oncotarget, 7 (43), 70589-70600. doi: 10.18632/oncotarget.12130

Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, Mckeone, Diane, Pearson, Sally-Ann, Klein, Kerenaftali, Leggett, Barbara and Whitehall, Vicki (2016). Serrated tubulovillous adenoma of the large intestine. Histopathology, 68 (4), 578-587. doi: 10.1111/his.12788

Wockner, L. F., Morris, C. P., Noble, E. P., Lawford, B. R., Whitehall, V. L.J., Young, R. M. and Voisey, J. (2015). Brain-specific epigenetic markers of schizophrenia. Translational Psychiatry, 5 (11) A177, e680-e680. doi: 10.1038/tp.2015.177

Bettington, Mark L., Walker, Neal I., Rosty, Christophe, Brown, Ian S., Clouston, Andrew D., McKeone, Diane M., Pearson, Sally Ann, Klein, Kerenaftali, Leggett, Barbara A. and Whitehall, Vicki L. (2015). A clinicopathological and molecular analysis of 200 traditional serrated adenomas. Modern Pathology, 28 (3), 414-427. doi: 10.1038/modpathol.2014.122

Bond, Catherine E., Bettington, Mark L., Pearson, Sally-Ann, McKeone, Diane M., Leggett, Barbara A. and Whitehall, Vicki (2015). Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups. BMC Cancer, 15 (1) 20, 20. doi: 10.1186/s12885-015-1011-9

Whitehall, V. L. J., Dumenil, T. D., McKeone, D. M., Bond, C. E., Bettington, M. L., Buttenshaw, R. L., Bowdler, L., Montgomery, G. W., Wockner, L. F. and Leggett, B. A. (2014). Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype. Epigenetics, 9 (11), 1454-1460. doi: 10.4161/15592294.2014.971624

Dumenil, Troy D., Wockner, Leesa F., Bettington, Mark, Mckeone, Diane M., Klein, Kerenaftali, Bowdler, Lisa M., Montgomery, Grant W., Leggett, Barbara A. and Whitehall, Vicki L. J. (2014). Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue. Genes Chromosomes and Cancer, 53 (7), 537-548. doi: 10.1002/gcc.22164

Bond, Catherine E., Nancarrow, Derek J., Wockner, Leesa F., Wallace, Leanne, Montgomery, Grant W., Leggett, Barbara A. and Whitehall, Vicki L. J. (2014). Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability. Plos One, 9 (3) e91739, e91739. doi: 10.1371/journal.pone.0091739

Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, Wockner, Leesa, Whitehall, Vicki and Leggett, Barbara (2014). Critical appraisal of the diagnosis of the sessile serrated adenoma. American Journal of Surgical Pathology, 38 (2), 158-166. doi: 10.1097/PAS.0000000000000103

Day, Fiona L., Jorissen, Robert N., Lipton, Lara, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Christie, Michael, Li, Shan, Tsui, Cary, Tie, Jeannie, Desai, Jayesh, Xu, Zheng-Zhou, Molloy, Peter, Whitehall, Vicki, Leggett, Barbara A., Jones, Ian T., McLaughlin, Stephen, Ward, Robyn L., Hawkins, Nicholas J., Ruszkiewicz, Andrew R., Moore, James, Busam, Dana, Zhao, Qi, Strausberg, Robert L., Gibbs, Peter and Sieber, Oliver M. (2013). PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in Colorectal cancer. Clinical Cancer Research, 19 (12), 3285-3296. doi: 10.1158/1078-0432.CCR-12-3614

Rosty, Christophe, Hewett, David G., Brown, Ian S., Leggett, Barbara A. and Whitehall, Vicki L. J. (2013). Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management. Journal of Gastroenterology, 48 (3), 287-302. doi: 10.1007/s00535-012-0720-y

Bettington, Mark, Walker, Neal, Clouston, Andrew, Brown, Ian, Leggett, Barbara and Whitehall, Vicki (2013). The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology, 62 (3), 367-386. doi: 10.1111/his.12055

Bond, Catherine E., Umapathy, Aarti, Buttenshaw, Ron L., Wockner, Leesa, Leggett, Barbara A. and Whitehall, Vicki L. J. (2012). Chromosomal instability in BRAF mutant, microsatellite stable colorectal cancers. Plos One, 7 (10) e47483, e47483.1-e47483.9. doi: 10.1371/journal.pone.0047483

Whitehall, Vicki L. J., Rickman, Celestine, Bond, Catherine E., Ramsnes, Ingunn, Greco, Sonia A., Umapathy, Aarti, McKeone, Diane, Faleiro, Rebecca J., Buttenshaw, Ron L., Worthley, Daniel L., Nayler, Sam, Zhao, Zhen Zhen, Montgomery, Grant W., Mallitt, Kylie-Ann, Jass, Jeremy R., Matsubara, Nagahide, Notohara, Kenji, Ishii, Tatsuhiro and Leggett, Barbara A. (2012). Oncogenic PIK3CA mutations in colorectal cancers and polyps. International Journal of Cancer, 131 (4), 813-820. doi: 10.1002/ijc.26440

Whitehall, Vicki and Leggett, Barbara (2011). Microsatellite instability: Detection and management in sporadic colorectal cancer. Journal of Gastroenterology and Hepatology, 26 (12), 1697-1699. doi: 10.1111/j.1440-1746.2011.06932.x

de Carcer, Daniel Aguirre, Ó Cuív, Páraic, Wang, Tingting, Kang, Seungha, Worthley, Daniel, Whitehall, Vicki, Gordon, Iain, McSweeney, Chris, Leggett, Barbara and Morrison, Mark (2011). Numerical ecology validates a biogeographical distribution and gender-based effect on mucosa-associated bacteria along the human colon. ISME Journal, 5 (5), 801-809. doi: 10.1038/ismej.2010.177

Ó Cuív, Páraic, de Carcer, Daniel Aguirre, Jones, Michelle, Klaassens, Eline S., Worthley, Daniel L., Whitehall, Vicki L. J., Kang, Seungha, McSweeney, Christopher S., Leggett, Barbara A. and Morrison, Mark (2011). The effects from DNA extraction methods on the evaluation of microbial diversity associated with human colonic tissue. Microbial Ecology, 61 (2), 353-362. doi: 10.1007/s00248-010-9771-x

Ishii, Tatsushiro, Notohara, Kenji, Umapathy, Aarti, Mallitt, Kylie-Ann, Chikuba, Hiroshi, Moritani, Yukitoshi, Tanaka, Noriaki, Rosty, Christophe, Matsubara, Nagahide, Jass, Jeremy, Leggett, Barbara and Whitehall, Vicki (2011). Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas. American Journal of Surgical Pathology, 35 (2), 212-220. doi: 10.1097/PAS.0b013e318205df20

Worthley, Daniel L., Whitehall, Vicki L. J., Le Leu, Richard K., Irahara, Natsumi, Buttenshaw, Ronald L., Mallitt, Kylie-Ann, Greco, Sonia A., Ramsnes, Ingunn, Winter, Jean, Hu, Ying, Ogino, Shuji, Young, Graeme P. and Leggett, Barbara A. (2011). DNA Methylation in the Rectal Mucosa Is Associated with Crypt Proliferation and Fecal Short-Chain Fatty Acids. Digestive Diseases and Sciences, 56 (2), 387-396. doi: 10.1007/s10620-010-1312-4

Bond, Catherine E., Umapathy, Aarti, Ramsnes, Ingunn, Greco, Sonia A., Zhao, Zhen Zhen, Mallitt, Kylie-Ann, Buttenshaw, Ron L., Montgomery, Grant W., Leggett, Barbara A. and Whitehall, Vicki L.J. (2011). p53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers. International Journal of Cancer, 130 (7), 1567-1576. doi: 10.1002/ijc.26175

Greco, Sonia A., Chia, June, Inglis, Kelly J., Cozzi, Sarah-Jane, Ramsnes, Ingunn, Buttenshaw, Ronald L., Spring, Kevin J., Boyle, Glen M., Worthley, Daniel L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2010). Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation. Bmc Cancer, 10 494. doi: 10.1186/1471-2407-10-494

Walker, R. Griff, Landmann, Juergen K., Hewett, David G., Worthley, Daniel L., Buttenshaw, Ron L., Knight, Ngaire, Webb, Penny M., Whiteman, David C., Whitehall, Vicki L. and Leggett, Barbara A. (2010). Hyperplastic Polyposis syndrome is associated with cigarette smoking, which may be a modifiable risk factor. The American Journal of Gastroenterology, 105 (7), 1642-1647. doi: 10.1038/ajg.2009.757

Worthley, Daniel L., Hewett, David G., Spring, Kevin J., Whitehall, Vicki L. J. and Leggett, Barbara A. (2010). Re: Protection from right-and left-sided colorectal neoplasms after colonoscopy: Population-based study. Journal of the National Cancer Institute, 102 (13), 990-990. doi: 10.1093/jnci/djq189

Leggett, Barbara and Whitehall, Vicki (2010). Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology, 138 (6), 2088-2100. doi: 10.1053/j.gastro.2009.12.066

Worthley, D. L., Whitehall, V. L. J., Buttenshaw, R. L., Irahara, N., Greco, S. A., Ramsnes, I., Mallitt, K-A, Le Leu, R. K., Winter, J., Hu, Y., Ogino, S., Young, G. P. and Leggett, B. A. (2010). DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer. Oncogene, 29 (11), 1653-1662. doi: 10.1038/onc.2009.449

Hinoue, Toshinori, Weisenberger, Daniel J., Pan, Fei, Campan, Mihaela, Kim, Myungjin, Young, Joanne, Whitehall, Vicki L., Leggett, Barbara A. and Laird, Peter W. (2009). Analysis of the Association between CIMP and BRAF(V600E) in Colorectal Cancer by DNA Methylation Profiling. PLoS One, 4 (12) e8357, e8357. doi: 10.1371/journal.pone.0008357

Loh, K, Chia, J. A., Greco, S., Cozzi, S.J., Buttenshaw, R.L., Bond, C.E., Simms, L.A., Pike, T., Young, J. P., Jass, J.R., Spring, K. J., Leggett, B. A. and Whitehall, V.L.J. (2008). Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development. Genes, Chromosomes & Cancer, 47 (6), 449-460. doi: 10.1002/gcc.20552

Worthley, D. L., Whitehall, V. L., Spring, K. J. and Leggett. B. A. (2007). Colorectal carcinogenesis: Road maps to cancer. World Journal of Gastroenterology, 13 (28), 3784-3791.

Chia, June A., Simms, Lisa A., Cozzi, Sarah-Jane, Young, Joanne, Jass, Jeremy R., Walsh, Michael D., Spring, Kevin J., Leggett, Barbara A. and Whitehall, Vicki L. J. (2006). SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers. BMC Cancer, 6 (252) 252, 1-6. doi: 10.1186/1471-2407-6-252

Spring, Kevin, Zhao, Zhen Zhen, Karamatic, Rozemary, Walsh, Michael, Whitehall, Vicki, Pike, Tanya, Simms, Lisa, Young, Joanne, James, Michael, Montgomery, Grant, Appleyard, Mark, Hewett, David, Togashi, Kazutomo, Jass, Jeremy and Leggett, Barbara (2006). High prevalence of sessile serrated adenomas with BRAF mutations: A prospective study of patients undergoing colonoscopy. Gastroenterology, 131 (5), 1400-1407. doi: 10.1053/j.gastro.2006.08.038

Young, Joanne, Simms, Lisa A., Barker, Melissa A., Walsh, Michael D., Biden, Kelli G., Buttenshaw, Ron, Whitehall, Vicki L.J., Arnold, Sven, Jackson, Leigh, Kambara, Takeshi, Spring, Kevin J., Jenkins, Mark A., Walker, Graeme J., Hopper, John L., Leggett, Barbara A. and Jass, Jeremy R. (2005). Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer. Clinical Gastroenterology and Hepatology, 3 (3), 254-263. doi: 10.1016/S1542-3565(04)00673-1

Kambara, T., Simms, L. A., Whitehall, V. L. J., Spring, K. J., Wynter, C. V. A., Walsh, M. D., Barker, M. A., Arnold, S., McGivern, A., Matsubara, N., Tanaka, N., Higuchi, T., Young, J., Jass, J. R. and Leggett, B. A. (2004). BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut, 53 (8), 1137-1144. doi: 10.1136/gut.2003.037671

Kambara, Takeshi, Whitehall, Vicki L. J., Spring, Kevin J., Barker, Melissa A., Arnold, Sven, Wynter, Coral V. A., Matsubara, Nagahide, Tanaka, Noriaki, Young, Joanne P., Leggett, Barbara A. and Jass, Jeremy R. (2004). Role of inherited defects of MYH in the development of sporadic colorectal cancer. Genes, Chromosomes and Cancer, 40 (1), 1-9. doi: 10.1002/gcc.20011

Young, J. P., Simms, L. A., Biden, K. G., Wynter, C. V. A., Whitehall, V. L., Karamatic, R., George, J., Goldblatt, J., Walpole, I., Robin, S., Borten, M. M., Stitz, R. W., Searle, J., McKeone, D. M. and Fraser, L. A. (2001). Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings. American Journal of Pathology, 159 (6), 2107-2116. doi: 10.1016/S0002-9440(10)63062-3

Herath, NI, Kew, MC, Whitehall, VLJ, Walsh, MD, Jass, JR, Khanna, KK, Young, J, Powell, LW, Leggett, BA and Macdonald, GA (2000). p73 is up-regulated in a subset of hepatocellular carcinomas. Hepatology, 31 (3), 601-605. doi: 10.1002/hep.510310309

Hourigan, L. F., Macdonald, G. A., Purdie, D., Whitehall, V. L. J., Shorthouse, C., Clouston, A. and Powell, E. E. (1999). Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. Hepatology, 29 (4), 1215-1219. doi: 10.1002/hep.510290401

Borowsky, J., Su, C., Fennell, L., Burge, M., Liu, J., Costa, A. Dias, Ogino, S., Mckeone, D., Olsen, K., Badshah, J., Bond, C., Nowlan, B., Tria, S., Laki, V., Walker, N., Brown, I., Bettington, M., Leggett, B. and Whitehall, V. (2023). KRAS mutant bowel cancers segregate into two distinct subgroups. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2023, Brisbane, QLD Australia, 2-5 September 2023. Hoboken, NJ United States: Wiley.

Nowlan, B., Borowsky, J., Dumenil, T., Tria, S., Wright, J., Fennell, L., Bond, C., McKeone, D., Hartel, G., Woods, S., Leggett, B. and Whitehall, V. (2023). Determining if osteopontin is an immune checkpoint of KRAS mutant colorectal cancer. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2023, Brisbane, QLD Australia, 2-5 September 2023. Richmond, VIC Australia: John Wiley & Sons.

Huber, Anne, Dijkstra, Christine, Whitehall, Vicki, Ernst, Matthias and Eissmann, Moritz (2022). Proof of principle that loss of mismatch repair protein reduces tumor burden in mouse model of gastric cancer. AACR Special Conference: Tumor Immunology and Immunotherapy, Boston, MA United States, 21-24 October 2022. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/2326-6074.tumimm22-a49

Su, C., Bond, C., Fennell, L., Kerr, G., Jarde, T., Micati, D., Engel, R., Chan, W. H., Hlavca, S., Archer, S., Mcmurrick, P., Hammerlindl, H., Lim, F., Salik, B., Mckeone, D., Hartel, G., Leggett, B., Schaider, H., Abud, H., Boyle, G., Burge, M. and Whitehall, V. (2021). Preclinical study of aspirin and regorafenib combination therapy for colorectal cancer. GESA AGW 2021, Online, 4 - 12 September 2021. HOBOKEN: WILEY.

Kane, A., Mckeone, D., Liu, C., Borowsky, J., Leggett, B. and Whitehall, V. (2019). Aspirin reduces the incidence of metastatic Braf mutant colorectal cancer in a preclinical trial. HOBOKEN: WILEY.

Fennell, L., Kane, A., Mckeone, D., Bond, C., Leggett, B. and Whitehall, V. (2019). Intestinal epigenetic age and risk of sessile serrated adenoma progression to cancer. HOBOKEN: WILEY.

Allen, Michael , Conroy, Sophie , Eastgate, Melissa , Wyld, David, Whitehall, Vicki and Burge, Matthew (2017). Outcomes comparing right and left-sided metastatic colorectal cancer: A multi-centre retrospective analysis in Queensland, Australia. Australasian Gastro-Intestinal Trials Group (AGITG) 2017 Annual Scientific Meeting, Cairns Convention Centre, Cairns, Australia, 4-6 October 2017. AGITG.

Fennell, L., Jamieson, S., Rohdmann, M., Furner, T., Mckeone, D., Kawamata, F., Bond, C., Leggett, B. and Whitehall, V. (2017). MLH1-93 single nucleotide polymorphism predisposes dysplastic sessile serrated adenomas to the development of promoter hypermethylation. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD, Australia, 20–22 August 2017. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13891

Kane, A., Mckeone, D., Jamieson, S., Liu, J., Leggett, B. and Whitehall, V. (2017). Chemoprevention with aspirin in a preclinical BRAF mutant model for sessile serrated adenomas. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD, Australia, 20–22 Aug 2017. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13891

Bond, C., Liu, C., Kawamata, F., Mckeone, D., Jamieson, S., Pearson, S., Woods, S., Lannagan, T., Fennell, L., Fernando, W., Bettington, M., Worthley, D., Leggett, B. and Whitehall, V. (2017). Oncogenic BRAF mutation induces widespread DNA hypermethylation in a murine model for human serrated colorectal neoplasia. AACR Annual Meeting 2017, Washington, DC, United States, April 1-5, 2017. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1158/1538-7445.AM2017-5375

Liu, C., Walker, N. I., Leggett, B. A., Whitehall, V. L. J., Bettington, M. L. and Rosty, C. (2017). Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD Australia, 20-22 August 2017. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

Liu, Cheng, Walken, Neal, Bettington, Mark, Rosty, Christophe, Leggett, Barbara and Whitehall, Vicki (2017). Morphologic and immunohistochemical characterization of sessile serrated adenomas with dysplasia. 106th Annual Meeting of the United-States and Canadian Academy of Pathology (USCAP), San Antonio, TX, United States, 4-10 March 2017. London, United Kingdom: Nature Publishing Group.

Whitehall, Vicki, Borowsky, Jennifer, Bond, Catherine, Bettington, Mark, Pearson, Sally-Ann, Kalimutho, Murugan, Liu, John, Dumenil, Troy, McKeone, Diane, Jamieson, Saara, Fernando, Winnie, Fennell, Lochlan, Clouston, Andrew, Rosty, Christophe, Brown, Ian, Walker, Neal and Leggett, Barbara (2017). Abstract PR04: Wnt and MAPK pathway activation in conventional and serrated colorectal neoplasia. AACR Special Conference: Colorectal Cancer: From Initiation to Outcomes, Tampa, FL, United States, 17-20 September 2016. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.crc16-pr04

Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, Pearson, Sally-Ann, McKeone, Diane, Leggett, Barbara and Whitehall, Vicki (2015). A clinicopathological and molecular analysis of 107 sessile serrated adenomas with dysplasia. 104th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, Boston, MA, United States, 21-27 March 2015. London, United Kingdom: Nature Publishing Group.

Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, Pearson, Sally-Ann, McKeone, Diane, Leggett, Barbara and Whitehall, Vicki (2015). A clinicopathological and molecular analysis of 107 sessile serrated adenomas with dysplasia. 104th Annual Meeting of the United States and Canadian Academy of Pathology, Boston, United States, 21-27 March, 2015. London, United Kingdom: Nature Publishing Group. doi: 10.1038/labinvest.2015.11

Bettington, M., Walker, N., Whitehall, Vicki, Vandeleur, Ann, Rahman, Tony, Leggett, Barbara and Croese, John (2015). Sessile serrated adenomas are highly prevalent in an outpatient population. 2015 GESA‐AGW and WGO International Congress, Brisbane, Australia, 28 September-2 October 2015. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13089

Fernando, W., Mckeone, D., Bettington, M., Pearson, S., Leggett, B. and Whitehall, V. (2015). Wnt and MAPK signalling in colorectal cancer morphology. Gastro 2015 GESA‐AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, QLD Australia, 28-September-1 October 2015. HOBOKEN: WILEY-BLACKWELL.

Bettington, M., Walker, N., Rosty, C., Brown, I., Clouston, A., Mckeone, D., Pearson, S., Leggett, B. and Whitehall, V. (2015). Clinicopathological and molecular features of sessile serrated adenomas with dysplasia and carcinoma differ by mismatch repair status. *, *, *. HOBOKEN: WILEY-BLACKWELL.

Bond, C., Kalimutho, M., Bettington, M., Pearson, S., Leggett, B. and Whitehall, V. (2015). Effects of the porcupine inhibitor, LGK974, on RNF43 mutant and wild type colorectal cancer cell lines. Abstracts of Gastro 2015 GESA‐AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, QLD, Australia, 28 September‐2 October 2015. Richmond, VIC, Australia: John Wiley & Sons.

Bettington, M., Walker, N., Brown, I., Rosty, C., Clouston, A., McKeone, D., Pearson, S-A, Leggett, B. and Whitehall, V. (2014). A clinicopathological and molecular appraisal of a large series of traditional serrated adenomas. 103rd Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), San Diego, CA, United States, 1-7 March 2014. London, United Kingdom: Nature Publishing Group.

Bettington, M., Brown, I., Walker, N., Rosty, C., Clouston, A., Pearson, S-A, Mckeone, D., Leggett, B. and Whitehall, V. (2014). Changing incidence of BRAF and KRAS mutations in colorectal carcinoma. Australian Gastroenterology Week 2014, Broadbeach, Australia, 22-24 October 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_2

Bettington, M., Walker, N., Brown, I., Rosty, C., Clouston, A., Pearson, S-A, Mckeone, D., Leggett, B. and Whitehall, V. (2014). Tubulovillous adenoma with prominent architectural serration - a clinicopathological and molecular appraisal of a new subtype of colorectal polyp. Australian Gastroenterology Week 2014, Broadbeach, Australia, 22-24 October 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_2

Bettington, M., Bond, C., Brown, I., Walker, N., Rosty, C., Clouston, A., Pearson, S-A, Mckeone, D., Leggett, B. and Whitehall, V. (2014). Wnt signaling in an unselected series of colorectal carcinomas. Australian Gastroenterology Week 2014, Broadbeach, Australia, 22-24 October 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_2

Bettington, M., Walker, N., Brown, I., Rosty, C., Clouston, A., McKeone, D., Pearson, S-A, Leggett, B. and Whitehall, V. (2014). A clinicopathological and molecular appraisal of a large series of traditional serrated adenomas. 103rd Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), San Diego, United States, Mar 01-07, 2014. London United Kingdom: Nature Publishing Group. doi: 10.1038/labinvest.2014.22

Dumenil, T. D., Klein, K., Wockner, L. F., Mckeone, D. M., Bowdler, L. M., Montgomery, G. W., Leggett, B. A. and Whitehall, V. L. J. (2014). Integrated genome wide DNA methylation and gene expression analysis identifies subgroups of colorectal cancer with distinct molecular and clinical features. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22‐24 October 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

Whitehall, V. L. J., Dumenil, T. D., Mckeone, D. M., Bond, C. E., Bettington, M. L., Buttenshaw, R. L., Bowdler, L., Montgomery, G. W., Wockner, L. F. and Leggett, B. A. (2014). Isocitrate Dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22‐24 October 2014. HOBOKEN: WILEY-BLACKWELL.

Whitehall, V. L. J., Mckeone, D., Ellis, J., Bond, C. E., Bettington, M. L., Pearson, S. A. and Leggett, B. A. (2014). RNF43 is a frequent mutational target in the serrated pathway of colorectal carcinogenesis. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22‐24 October 2014. HOBOKEN: WILEY-BLACKWELL.

Bond, C., Bettington, M., Pearson, S., Mckeone, D., Wockner, L., Leggett, B. and Whitehall, V. (2014). Methylation and expression of the tumor suppressor, PRDM5, in colorectal cancer subgroups. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22‐24 October 2014. HOBOKEN: WILEY-BLACKWELL.

De Carcer, D. Aguirre, O Cuiv, P., Wang, T., Reverter, T., Worthley, D., Whitehall, V., Klaassens, E. S., Kang, S., Denman, S., Young, G., Legget, B., McSweeney, C. and Morrison, M. (2009). Application of numerical ecology methods to microarray data reveals obscured patterns in the mucosa-associated microbial community of the human colorectum. Australia and New Zealand Medical and Surgical Gastrointestinal Week 2009, Sydney, NSW Australia, 21‐24 October 2009. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

Togashi, K, Hewett, DG, Spring, K, Whitehall, V, Kurashina, K, Hone, H, Yasuda, Y, Appleyard, MN, Jass, J and Leggett, BA (2008). Prevalence of serrated polyps: Is there a difference between Australia and Japan?. Unknown, Unknown, Unknown. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.

Fernando, W., Worthley, D. L., Whitehall, V. L., Leggett, B. A. and Spring, K. J. (2008). SLC5A8 methylation, CIMP and BRAF mutation in serrated polyps of the colorectum. Australian Gastroenterology Week 2008, Brisbane, Australia, 22-25 October 2008. Melbourne, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2008.05611.x

Walker, G., Whitehall, V. L., Knight, N., Buttenshaw, R. L., Hewett, D. G., Worthley, D. and Leggett, B. A. (2008). An association between hyperplastic polyposis syndrome and cigarette smoking, a modifiable risk factor. Australian Gastroenterology Week, Brisbane, Qld, Australia, 22-25 October 2008. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2008.05611.x

Whitehall, V. L., Walsh, M., Jass, J. R., Young, J. and Leggett, B. A. (2000). A study of p14-ARF in sporadic colorectal cancer. 12th Lorne Cancer Conference, Lorne, Melbourne, 10-13 Feb, 2000.

Whitehall, V. L., Walsh, M., Jass, J. R., Young, J. P. and Leggett, B. A. (2000). p14-ARF and p16-INK4A - one locus, two genes frequently affected in sporadic colorectal cancer. Australian Gastroenterology Week 2000, Hobart, 18-21 Oct, 2000. Melbourn: Blackwell Scientific.

Dutton, P., Mccart, A., Whitehall, V. L. and Ebert, P. R. (1999). Comparative genomic and detailed structural analysis of the GABA neurotransmitter transporter gene family between vertebrates and the invertebrates, Apis Mellifera and C.elegans. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology.

Herath, N. I., Kew, M. C., Whitehall, V. L., Young, J. P., Powell, L. W., Leggett, B. A. and Macdonald, G. A. (1999). Up-regulation of P73 in hepatocellular carcinoma. Entering a New Era, Wyndham Anatole Hotel, Dallas, Texas, 5-9 November, 1999. Hoboken, NJ: Wiley Interscience.

Wright, C.M., Whitehall, V. L., Dent, O. F., Walsh, M. D., Searle, J., Newland, R. C., Chapuis, P. H., Jass, J. R., Young, J. P., Leggett, B. A. and Macdonald, G. (1999). Improved survival in stage C colorectal cancers exhibiting microsatellite instability. From Genes to the Clinic & Beyond. Understanding & Managing Bowel Cancer, Melbourne & Lorne, 1 - 6 March 1999.

Whitehall, V. L., Simms, L. A., Jass, J. R., Young, J. P. and Leggett, B. A. (1999). CASPASE-5 - A target gene for mutation in the microsatellite mutator pathway of sporadic colorectal cancers?. Royal Brisbane Hospital Health Care Symposium, Westpac Auditorium Bancroft Cen., QIMR, Brisbane, 21 - 27 Oct, 1999. Brisbane: Royal Brisbane Hospital.

Ebert, P. R., Meadows, B., Humphries, M., Swasdipan, N., Whitehall, V. L. and Doan, T. (1999). Structural features of the biogenic amine receptor genes. XIII International Congress of IUSSI: IUSSI 1999, Adelaide, SA, Australia, 29 December 1998 - 4 January 1999. United States: IUSSI.

Whitehall, Vicki L. J. (2002). Molecular mechanisms of carcinogenesis in sporadic, microsatellite unstable colorectal cancer. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/246366

Honorary Professor Vicki Whitehall

Publications

Journal Articles

Conference Papers

Thesis