Book Chapter
Engwerda, Christian R., Bukali, Luzia, Mehrotra, Sanjana and Kumar, Rajiv (2024). Host-Directed Therapy for Protozoan Parasitic Diseases. Reference Module in Life Sciences. Elsevier. doi: 10.1016/b978-0-128-24465-4.00106-x
Journal Articles
Mukhiya, Reena, Fleischmann, Wim A., Loughland, Jessica R., Chan, Jo-Anne, de Labastida Rivera, Fabian, Andrew, Dean, Beeson, James G., McCarthy, James S., Barber, Bridget E., Lopez, J. Alejandro, Engwerda, Christian, Thomson-Luque, Richard and Boyle, Michelle J. (2024). Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection. eBioMedicine, 109 105419, 105419. doi: 10.1016/j.ebiom.2024.105419
Boyle, Michelle J., Engwerda, Christian R. and Jagannathan, Prasanna (2024). The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria. Nature Reviews Immunology, 24 (9), 637-653. doi: 10.1038/s41577-024-01041-5
Na, Jinrui and Engwerda, Christian (2024). The role of CD4+ T cells in visceral leishmaniasis; new and emerging roles for NKG7 and TGFβ. Frontiers in Cellular and Infection Microbiology, 14 1414493. doi: 10.3389/fcimb.2024.1414493
Gao, Yulong, Souza-Fonseca-Guimaraes, Fernando, Bald, Tobias, Ng, Susanna S., Young, Arabella, Ngiow, Shin Foong, Rautela, Jai, Straube, Jasmin, Waddell, Nic, Blake, Stephen J., Yan, Juming, Bartholin, Laurent, Lee, Jason S., Vivier, Eric, Takeda, Kazuyoshi, Messaoudene, Meriem, Zitvogel, Laurence, Teng, Michele W. L., Belz, Gabrielle T., Engwerda, Christian R., Huntington, Nicholas D., Nakamura, Kyohei, Hölzel, Michael and Smyth, Mark J. (2024). Correction to: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells (Nature Immunology, (2017), 18, 9, (1004-1015), 10.1038/ni.3800). Nature Immunology, 25 (5), 925-926. doi: 10.1038/s41590-024-01799-9
Kausar, Gulafsha, Chauhan, Shashi B., Roy, Ritirupa, Kumar, Shashi, Engwerda, Christian, Nylen, Susanne, Kumar, Rajiv, Wilson, Mary E. and Sundar, Shyam (2024). Apolipoprotein E Is Upregulated in Blood and Circulating Monocytes of Indian Patients With Visceral Leishmaniasis. Parasite Immunology, 46 (5) e13036. doi: 10.1111/pim.13036
Kausar, Gulafsha, Chauhan, Shashi Bhushan, Roy, Ritirupa, Verma, Vimal, Pandey, Sundaram, Niyaz, Aziza, Chakravarty, Jaya, Engwerda, Christian R., Nylen, Susanne, Kumar, Rajiv, Wilson, Mary E. and Sundar, Shyam (2024). Phenotypic and functional characteristics of monocyte subsets in the blood and bone marrow of Indian subjects with Visceral Leishmaniasis. PLOS Neglected Tropical Diseases, 18 (4) e0012112, e0012112. doi: 10.1371/journal.pntd.0012112
Kumar, Shashi, Chauhan, Shashi Bhushan, Upadhyay, Shreya, Singh, Siddharth Sankar, Verma, Vimal, Kumar, Rajiv, Engwerda, Christian, Nylén, Susanne and Sundar, Shyam (2024). Altered IL-7 signaling in CD4+ T cells from patients with visceral leishmaniasis. PLoS neglected tropical diseases, 18 (2) e0011960, e0011960. doi: 10.1371/journal.pntd.0011960
Ng, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2024). Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 25 (4), 716-716. doi: 10.1038/s41590-024-01770-8
Dooley, Nicholas L., Chabikwa, Tinashe G., Pava, Zuleima, Loughland, Jessica R., Hamelink, Julianne, Berry, Kiana, Andrew, Dean, Soon, Megan S. F., SheelaNair, Arya, Piera, Kim A., William, Timothy, Barber, Bridget E., Grigg, Matthew J., Engwerda, Christian R., Lopez, J. Alejandro, Anstey, Nicholas M. and Boyle, Michelle J. (2023). Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets. Nature Communications, 14 (1) 7387, 1-22. doi: 10.1038/s41467-023-43181-7
Edwards, Chelsea L., Engel, Jessica A., De Labastida Rivera, Fabian, Ng, Susanna S., Corvino, Dillon, Montes de Oca, Marcela, Frame, Teija C.M., Chauhan, Shashi Bhushan, Singh, Siddharth Sanker, Kumar, Awnish, Wang, Yulin, Na, Jinrui, Mukhopadhyay, Pamela, Lee, Jason S., Nylén, Susanne, Sundar, Shyam, Kumar, Rajiv and Engwerda, Christian R. (2023). A molecular signature for IL-10-producing Th1 cells in protozoan parasitic diseases. JCI Insight, 8 (24) e169362, 1-17. doi: 10.1172/jci.insight.169362
Wang, Yulin, De Labastida Rivera, Fabian, Edwards, Chelsea L., Frame, Teija C.M., Engel, Jessica A., Bukali, Luzia, Na, Jinrui, Ng, Susanna S., Corvino, Dillon, Montes de Oca, Marcela, Bunn, Patrick T., Soon, Megan S.F., Andrew, Dean, Loughland, Jessica R., Zhang, Jia, Amante, Fiona H., Barber, Bridget E., McCarthy, James S., Lopez, J. Alejandro, Boyle, Michelle J. and Engwerda, Christian R. (2023). STING activation promotes autologous type I interferon–dependent development of type 1 regulatory T cells during malaria. Journal of Clinical Investigation, 133 (19) e169417. doi: 10.1172/jci169417
Kumar, Awnish, Singh, Vishal Kumar, Tiwari, Rahul, Madhukar, Prasoon, Rajneesh,, Kumar, Shashi, Gautam, Vibhav, Engwerda, Christian, Sundar, Shyam and Kumar, Rajiv (2023). Post kala-azar dermal leishmaniasis in the Indian sub-continent: challenges and strategies for elimination. Frontiers in Immunology, 14 1236952, 1-10. doi: 10.3389/fimmu.2023.1236952
Edwards, Chelsea L., Ng, Susanna S., de Labastida Rivera, Fabian, Corvino, Dillon, Engel, Jessica A., Montes de Oca, Marcela, Bukali, Luzia, Frame, Teija C.M., Bunn, Patrick T., Chauhan, Shashi Bhushan, Singh, Siddharth Sankar, Wang, Yulin, Na, Jinrui, Amante, Fiona H., Loughland, Jessica R., Soon, Megan S.F., Waddell, Nicola, Mukhopadhay, Pamela, Koufariotis, Lambros T., Johnston, Rebecca L., Lee, Jason S., Kuns, Rachel, Zhang, Ping, Boyle, Michelle J., Hill, Geoffrey R., McCarthy, James S., Kumar, Rajiv and Engwerda, Christian R. (2023). Corrigendum: IL-10–producing Th1 cells possess a distinct molecular signature in malaria. Journal of Clinical Investigation, 133 (4) e169299. doi: 10.1172/jci169299
Edwards, Chelsea L., Ng, Susanna S., de Labastida Rivera, Fabian, Corvino, Dillon, Engel, Jessica A., Montes de Oca, Marcela, Bukali, Luzia, Frame, Teija C.M., Bunn, Patrick T., Chauhan, Shashi Bhushan, Singh, Siddharth Sankar, Wang, Yulin, Na, Jinrui, Amante, Fiona H., Loughland, Jessica R., Soon, Megan S.F., Waddell, Nicola, Mukhopadhay, Pamela, Koufariotis, Lambros T., Johnston, Rebecca L., Lee, Jason S., Kuns, Rachel, Zhang, Ping, Boyle, Michelle J., Hill, Geoffrey R., McCarthy, James S., Kumar, Rajiv and Engwerda, Christian R. (2023). IL-10-producing Th1 cells possess a distinct molecular signature in malaria. Journal of Clinical Investigation, 133 (1) e153733. doi: 10.1172/jci153733
Ryan, Stephanie M., Ruscher, Roland, Johnston, Wayne A., Pickering, Darren A., Kennedy, Malcolm W., Smith, Brian O., Jones, Linda, Buitrago, Geraldine, Field, Matt A., Esterman, Adrian J., McHugh, Connor P., Browne, Daniel J., Cooper, Martha M., Ryan, Rachael Y M, Doolan, Denise L., Engwerda, Christian R., Miles, Kim, Mitreva, Makedonka, Croese, John, Rahman, Tony, Alexandrov, Kirill, Giacomin, Paul R. and Loukas, Alex (2022). Novel antiinflammatory biologics shaped by parasite-host coevolution. Proceedings of the National Academy of Sciences of the United States of America, 119 (36) 2202795119, 1-9. doi: 10.1073/pnas.2202795119
Singh, Siddharth Sankar, Chauhan, Shashi Bhushan, Ng, Susanna SS, Corvino, Dillon, de Labastida Rivera, Fabian, Engel, Jessica A, Waddell, Nic, Mukhopadhay, Pamela, Johnston, Rebecca L, Koufariotis, Lambros T, Nylen, Susanne, Prakash Singh, Om, Engwerda, Christian R, Kumar, Rajiv and Sundar, Shyam (2022). Increased amphiregulin expression by CD4+ T cells from individuals with asymptomatic Leishmania donovani infection. Clinical and Translational Immunology, 11 (6) e1396, 1-14. doi: 10.1002/cti2.1396
Chughlay, M. Farouk, Barnes, Karen I., El Gaaloul, Myriam, Abla, Nada, Möhrle, Jörg J., Griffin, Paul, van Giersbergen, Paul, Reuter, Stephanie E., Schultz, Hayley B., Kress, Anita, Tapley, Peter, Webster, Rebecca A., Wells, Timothy, McCarthy, James S., Barber, Bridget E., Marquart, Louise, Boyle, Michelle J., Engwerda, Christian R. and Chalon, Stephan (2022). Safety, tolerability, pharmacokinetics, and pharmacodynamics of coadministered Ruxolitinib and Artemether-Lumefantrine in healthy adults. Antimicrobial Agents and Chemotherapy, 66 (1) e01584-21, e0158421. doi: 10.1128/AAC.01584-21
Li, Xian-Yang, Corvino, Dillon, Nowlan, Bianca, Aguilera, Amelia Roman, Ng, Susanna S., Braun, Matthias, Cillo, Anthony R., Bald, Tobias, Smyth, Mark J. and Engwerda, Christian R. (2022). NKG7 is required for optimal antitumor t-cell immunity. Cancer Immunology Research, 10 (2), 154-161. doi: 10.1158/2326-6066.cir-20-0649
Webster, Rebecca, Sekuloski, Silvana, Odedra, Anand, Woolley, Stephen, Jennings, Helen, Amante, Fiona, Trenholme, Katharine R., Healer, Julie, Cowman, Alan F., Eriksson, Emily M., Sathe, Priyanka, Penington, Jocelyn, Blanch, Adam J., Dixon, Matthew W. A., Tilley, Leann, Duffy, Michael F., Craig, Alister, Storm, Janet, Chan, Jo-Anne, Evans, Krystal, Papenfuss, Anthony T., Schofield, Louis, Griffin, Paul, Barber, Bridget E., Andrew, Dean, Boyle, Michelle J., de Labastida Rivera, Fabian, Engwerda, Christian and McCarthy, James S. (2021). Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine. BMC Medicine, 19 (1) 293, 293. doi: 10.1186/s12916-021-02150-x
Chapman, Paul R., Webster, Rebecca, Giacomin, Paul, Llewellyn, Stacey, Becker, Luke, Pearson, Mark S., De Labastida Rivera, Fabian, O'Rourke, Peter, Engwerda, Christian R., Loukas, Alex and McCarthy, James S. (2021). Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial. The Lancet Infectious Diseases, 21 (12), 1725-1736. doi: 10.1016/S1473-3099(21)00153-5
Singh, Siddharth S., Chauhan, Shashi B., Kumar, Awnish, Kumar, Shashi, Engwerda, Christian R., Sundar, Shyam and Kumar, Rajiv (2021). Amphiregulin in cellular physiology, health, and disease: potential use as a biomarker and therapeutic target. Journal of Cellular Physiology, 237 (2), 1143-1156. doi: 10.1002/jcp.30615
McConville, Malcolm J and Engwerda, Christian R (2021). Malaria thriving on steroids. Nature metabolism, 3 (7), 892-893. doi: 10.1038/s42255-021-00416-5
Mills, Richard J., Humphrey, Sean J., Fortuna, Patrick R. J., Lor, Mary, Foster, Simon R., Quaife-Ryan, Gregory A., Johnston, Rebecca L., Dumenil, Troy, Bishop, Cameron, Rudraraju, Rajeev, Rawle, Daniel J., Le, Thuy, Zhao, Wei, Lee, Leo, Mackenzie-Kludas, Charley, Mehdiabadi, Neda R., Halliday, Christopher, Gilham, Dean, Fu, Li, Nicholls, Stephen J., Johansson, Jan, Sweeney, Michael, Wong, Norman C. W., Kulikowski, Ewelina, Sokolowski, Kamil A., Tse, Brian W. C., Devilée, Lynn, Voges, Holly K., Reynolds, Liam T. ... Hudson, James E. (2021). BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection. Cell, 184 (8), 2167-2182.e22. doi: 10.1016/j.cell.2021.03.026
Loughland, Jessica R., Woodberry, Tonia, Oyong, Damian, Piera, Kim A., Amante, Fiona H., Barber, Bridget E., Grigg, Matthew J., William, Timothy, Engwerda, Christian R., Anstey, Nicholas M., McCarthy, James S., Boyle, Michelle J. and Minigo, Gabriela (2021). Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels. Malaria Journal, 20 (1) 97, 1-8. doi: 10.1186/s12936-021-03642-0
Singh, Om Prakash, Syn, Genevieve, Nylén, Susanne, Engwerda, Christian, Sacks, David, Wilson, Mary E, Kumar, Rajiv, Chakravarty, Jaya, Sundar, Shyam, Blackwell, Jenefer M and Fakiola, Michaela (2021). Anti-interleukin-10 unleashes transcriptional response to leishmanial antigens in visceral leishmaniasis patients. The Journal of Infectious Diseases, 223 (3), 517-521. doi: 10.1093/infdis/jiaa381
Chan, Jo-Anne, Loughland, Jessica R, de Labastida Rivera, Fabian, SheelaNair, Arya, Andrew, Dean W, Dooley, Nicholas L, Wines, Bruce D, Amante, Fiona H, Webb, Lachlan, Hogarth, P Mark, McCarthy, James S, Beeson, James G, Engwerda, Christian R and Boyle, Michelle J (2020). Th2-like T Follicular helper cells promote functional antibody production during infection. Cell reports. Medicine, 1 (9) 100157, 100157. doi: 10.1016/j.xcrm.2020.100157
Montes de Oca, Marcela, de Labastida Rivera, Fabian, Winterford, Clay, Frame, Teija C. M., Ng, Susanna S., Amante, Fiona H., Edwards, Chelsea L., Bukali, Luzia, Wang, Yulin, Uzonna, Jude E., Kuns, Rachel D., Zhang, Ping, Kabat, Agnieszka, Klein Geltink, Ramon I., Pearce, Edward J., Hill, Geoffrey R. and Engwerda, Christian R. (2020). IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. PLoS Pathogens, 16 (10) e1008994, e1008994. doi: 10.1371/journal.ppat.1008994
Montes de Oca, Marcela, Engwerda, Christian R and Kaye, Paul M (2020). Cytokines and splenic remodelling during infection. Cytokine: X, 2 (4) 100036, 100036. doi: 10.1016/j.cytox.2020.100036
Engel, Jessica A. and Engwerda, Christian R. (2020). A new era of rational malaria vaccine development. Immunology and cell biology, 98 (8), 620-622. doi: 10.1111/imcb.12384
Ng, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2020). The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 21 (10), 1205-1218. doi: 10.1038/s41590-020-0758-6
Guillerey, Camille, Stannard, Kimberley, Chen, Jason, Krumeich, Sophie, Miles, Kim, Nakamura, Kyohei, Smith, Jessica, Yu, Yuan, Ng, Susanna, Harjunpää, Heidi, Teng, Michele W. L., Engwerda, Christian, Belz, Gabrielle T. and Smyth, Mark J. (2020). Systemic administration of IL‐33 induces a population of circulating KLRG1 hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma. Immunology and Cell Biology, 99 (1) imcb.12390, 65-83. doi: 10.1111/imcb.12390
Vijay, Rahul, Guthmiller, Jenna J, Sturtz, Alexandria J, Surette, Fionna A, Rogers, Kai J, Sompallae, Ramakrishna R, Li, Fengyin, Pope, Rosemary L, Chan, Jo-Anne, de Labastida Rivera, Fabian, Andrew, Dean, Webb, Lachlan, Maury, Wendy J, Xue, Hai-Hui, Engwerda, Christian R, McCarthy, James S, Boyle, Michelle J and Butler, Noah S (2020). Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria. Nature Immunology, 21 (7), 790-801. doi: 10.1038/s41590-020-0678-5
Loughland, Jessica R, Woodberry, Tonia, Field, Matt, Andrew, Dean W, SheelaNair, Arya, Dooley, Nicholas L, Piera, Kim A, Amante, Fiona H, Kenangalem, Enny, Price, Ric N, Engwerda, Christian R, Anstey, Nicholas M, McCarthy, James S, Boyle, Michelle J and Minigo, Gabriela (2020). Transcriptional profiling and immunophenotyping show sustained activation of blood monocytes in subpatent infection. Clinical and Translational Immunology, 9 (6) e1144, e1144. doi: 10.1002/cti2.1144
Cheong, Melody, Gartlan, Kate H., Lee, Jason S., Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D., Andoniou, Christopher E., Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R., Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A., Boyle, Glen M., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Trapani, Joseph A., Degli-Esposti, Mariapia A., Koyama, Motoko and Hill, Geoffrey R. (2020). ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome. Cancer Immunology Research, 8 (8), 1085-1098. doi: 10.1158/2326-6066.cir-19-0653
Kumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., Montes de Oca, Marcela, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude ... Engwerda, Christian R. (2020). Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis. Cell Reports, 30 (8), 2512-2525.e9. doi: 10.1016/j.celrep.2020.01.099
Sidwell, Tom, Liao, Yang, Garnham, Alexandra L, Vasanthakumar, Ajithkumar, Gloury, Renee, Blume, Jonas, Teh, Peggy P, Chisanga, David, Thelemann, Christoph, de Labastida Rivera, Fabian, Engwerda, Christian R, Corcoran, Lynn, Kometani, Kohei, Kurosaki, Tomohiro, Smyth, Gordon K, Shi, Wei and Kallies, Axel (2020). Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis. Nature Communications, 11 (1) 252, 252. doi: 10.1038/s41467-019-14112-2
Soon, Megan S. F., Lee, Hyun Jae, Engel, Jessica A., Straube, Jasmin, Thomas, Bryce S., Pernold, Clara P. S., Clarke, Lachlan S., Laohamonthonkul, Pawat, Haldar, Rohit N., Williams, Cameron G., Lansink, Lianne I. M., Moreira, Marcela L., Bramhall, Michael, Koufariotis, Lambros T., Wood, Scott, Chen, Xi, James, Kylie R., Lönnberg, Tapio, Lane, Steven W., Belz, Gabrielle T., Engwerda, Christian R., Khoury, David S., Davenport, Miles P., Svensson, Valentine, Teichmann, Sarah A. and Haque, Ashraful (2020). Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory. Nature Immunology, 21 (12), 1597-1610. doi: 10.1038/s41590-020-0800-8
Kumar, Rajiv, Loughland, Jessica R., Ng, Susanna S., Boyle, Michelle J. and Engwerda, Christian R. (2020). The regulation of CD4+ T cells during malaria. Immunological Reviews, 293 (1), 70-87. doi: 10.1111/imr.12804
Singh, Bhawana, Bhushan Chauhan, Shashi, Kumar, Rajiv, Singh, Siddharth Sankar, Ng, Susanna, Amante, Fiona, de Labastida Rivera, Fabian, Singh, Om Prakash, Rai, Madhukar, Nylen, Susanne, Sundar, Shyam and Engwerda, Christian (2019). A molecular signature for CD8+ T cells from visceral leishmaniasis patients. Parasite immunology, 41 (11) e12669, e12669. doi: 10.1111/pim.12669
Boyle, M. J., Chan, J. A., Handayuni, I., Reiling, L., Feng, G., Hilton, A., Kurtovic, L., Oyong, D., Piera, K. A., Barber, B. E., William, T., Eisen, D. P., Minigo, G., Langer, C., Drew, D. R., de Labastida Rivera, F., Amante, F. H., Williams, T. N., Kinyanjui, S., Marsh, K., Doolan, D. L., Engwerda, C., Fowkes, F. J.I., Grigg, M. J., Mueller, I., McCarthy, J. S., Anstey, N. M. and Beeson, J. G. (2019). IgM in human immunity to Plasmodium falciparum malaria. Science Advances, 5 (9) eaax4489, eaax4489. doi: 10.1126/sciadv.aax4489
Oyong, Damian A., Loughland, Jessica R., Sheelanair, Arya, Andrew, Dean, Rivera, Fabian D. L., Piera, Kim A., William, Timothy, Grigg, Matthew J., Barber, Bridget E., Haque, Ashraful, Engwerda, Christian R., McCarthy, James S., Anstey, Nicholas M. and Boyle, Michelle J. (2019). Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection. Malaria Journal, 18 (1) 312, 312. doi: 10.1186/s12936-019-2962-0
Chauhan, Shashi Bhushan, Faleiro, Rebecca, Kumar, Rajiv, Ng, Susanna, Singh, Bhawana, Singh, Om Prakash, Singh, Siddharth Sankar, Amante, Fiona, Rivera, Fabian de Labastida, Rai, Madhukar, Chakravarty, Jaya, Sacks, David, Nylen, Susanne, Sundar, Shyam and Engwerda, Christian (2019). Interleukin 2 is an upstream regulator of CD4+ T cells from visceral leishmaniasis patients with therapeutic potential. The Journal of Infectious Diseases, 220 (1) jiz074, 163-173. doi: 10.1093/infdis/jiz074
Loughland, Jessica R, Woodberry, Tonia, Boyle, Michelle J, Tipping, Peta E, Piera, Kim A, Amante, Fiona H, Kenangalem, Enny, Price, Ric N, Engwerda, Christian R, Anstey, Nicholas M, McCarthy, James S and Minigo, Gabriela (2019). Plasmodium falciparum activates CD16+ dendritic cells to produce tumor necrosis factor and interleukin-10 in subpatent malaria. The Journal of infectious diseases, 219 (4), 660-671. doi: 10.1093/infdis/jiy555
Kumar, Rajiv, Ng, Susanna and Engwerda, Christian (2019). The role of IL-10 in malaria: A double edged sword. Frontiers in Immunology, 10 (FEB) 229. doi: 10.3389/fimmu.2019.00229
Ng, Susanna S and Engwerda, Christian R (2019). Innate lymphocytes and malaria: players or spectators?. Trends in parasitology, 35 (2), 154-162. doi: 10.1016/j.pt.2018.11.012
Bunn, Patrick T., Montes de Oca, Marcela, de Labastida Rivera, Fabian, Kumar, Rajiv, Ng, Susanna S., Edwards, Chelsea L., Faleiro, Rebecca J., Sheel, Meru, Amante, Fiona H., Frame, Teija C. M., Muller, Werner, Haque, Ashraful, Uzonna, Jude E., Hill, Geoffrey R. and Engwerda, Christian R. (2018). Distinct roles for CD4+ Foxp3+ regulatory T cells and IL-10–mediated immunoregulatory mechanisms during experimental visceral Leishmaniasis caused by Leishmania donovani. The Journal of Immunology, 201 (11), 3362-3372. doi: 10.4049/jimmunol.1701582
Edwards, Chelsea L., de Oca, Marcela Montes, Rivera, Fabian de Labastida, Kumar, Rajiv, Ng, Susanna S., Wang, Yulin, Amante, Fiona H., Kometani, Kohei, Kurosaki, Tomohiro, Sidwell, Tom, Kallies, Axel and Engwerda, Christian R. (2018). The Role of BACH2 in T Cells in Experimental Malaria Caused by Plasmodium chabaudi chabaudi AS. Frontiers in Immunology, 9 (NOV) 02578, 2578. doi: 10.3389/fimmu.2018.02578
Minnie, Simone A., Kuns, Rachel D., Gartlan, Kate H., Zhang, Ping, Wilkinson, Andrew N., Samson, Luke, Guillerey, Camille, Engwerda, Christian, MacDonald, Kelli P. A., Smyth, Mark J., Markey, Kate A., Vuckovic, Slavica and Hill, Geoffrey R. (2018). Myeloma escape after stem cell transplantation is a consequence of t-cell exhaustion and is prevented by tigit blockade. Blood, 132 (16), 1675-1688. doi: 10.1182/blood-2018-01-825240
Singh, Neetu, Kumar, Rajiv, Chauhan, Shashi Bhushan, Engwerda, Christian and Sundar, Shyam (2018). Peripheral blood monocytes with an antiinflammatory phenotype display limited phagocytosis and oxidative burst in patients with visceral leishmaniasis. The Journal of Infectious Diseases, 218 (7), 1130-1141. doi: 10.1093/infdis/jiy228
Edwards, Chelsea L., Ng, Susanna S., Corvino, Dillon, Montes de Oca, Marcela, Rivera, Fabian de Labastida, Nones, Katia, Lakis, Vanessa, Waddell, Nicola, Amante, Fiona H., McCarthy, James S. and Engwerda, Christian R. (2018). Early changes in CD4+ T-cell activation following blood-stage Plasmodium falciparum infection. The Journal of Infectious Diseases, 218 (7), 1119-1129. doi: 10.1093/infdis/jiy281
Eichenberger, Ramon M., Ryan, Stephanie, Jones, Linda, Buitrago, Geraldine, Polster, Ramona, Montes de Oca, Marcela, Zuvelek, Jennifer, Giacomin, Paul R., Dent, Lindsay A., Engwerda, Christian R., Field, Matthew A., Sotillo, Javier and Loukas, Alex (2018). Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice. Frontiers in Immunology, 9 (APR) 850. doi: 10.3389/fimmu.2018.00850
James, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782
Ng, Susanna S., Souza-Fonseca-Guimaraes, Fernando, Rivera, Fabian de Labastida, Amante, Fiona H., Kumar, Rajiv, Gao, Yulong, Sheel, Meru, Beattie, Lynette, de Oca, Marcela Montes, Guillerey, Camille, Edwards, Chelsea L., Faleiro, Rebecca J., Frame, Teija, Bunn, Patrick T., Vivier, Eric, Godfrey, Dale I., Pellicci, Daniel G., Lopez, J. Alejandro, Andrews, Katherine T., Huntington, Nicholas D., Smyth, Mark J., McCarthy, James and Engwerda, Christian R. (2018). Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection. Clinical and Translational Immunology, 7 (1) e1003, e1003. doi: 10.1002/cti2.1003
Kumar, Rajiv, Chauhan, Shashi Bhushan, Ng, Susanna S., Sundar, Shyam and Engwerda, Christian R. (2017). Immune checkpoint targets for host-directed therapy to prevent and treat leishmaniasis. Frontiers in Immunology, 8 (NOV) 1492. doi: 10.3389/fimmu.2017.01492
Bunn, Patrick T., de Oca, Marcela Montes, Rivera, Fabian de Labastida, Kumar, Rajiv, Edwards, Chelsea L., Faleiro, Rebecca J., Ng, Susanna S., Sheel, Meru, Wang, Yulin, Amante, Fiona H., Haque, Ashraful and Engwerda, Christian R. (2017). Galectin-1 Impairs the Generation of Anti-Parasitic Th1 Cell Responses in the Liver during Experimental Visceral Leishmaniasis. Frontiers in Immunology, 8 (OCT) 1307, 1307. doi: 10.3389/fimmu.2017.01307
Sebina, I., Fogg, L. G., James, K. R., Soon, M. S. F., Akter, J., Thomas, B. S., Hill, G. R., Engwerda, C. R. and Haque, A. (2017). IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection. Parasite Immunology, 39 (10) e12455, e12455. doi: 10.1111/pim.12455
Gao, Yulong, Souza-Fonseca-Guimaraes, Fernando, Bald, Tobias, Ng, Susanna S., Young, Arabella, Ngiow, Shin Foong, Rautela, Jai, Straube, Jasmin, Waddell, Nic, Blake, Stephen J., Yan, Juming, Bartholin, Laurent, Lee, Jason S., Vivier, Eric, Takeda, Kazuyoshi, Messaoudene, Meriem, Zitvogel-, Laurence, Teng, Michele W. L., Belz, Gabrielle T., Engwerda, Christian R., Huntington, Nicholas D., Nakamura, Kyohei, Hoelzel, Michael and Smyth, Mark J. (2017). Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells. Nature Immunology, 18 (9), 1004-1015. doi: 10.1038/ni.3800
Loughland, Jessica R., Minigo, Gabriela, Sarovich, Derek S., Field, Matt, Tipping, Peta E., Montes de Oca, Marcela, Piera, Kim A., Amante, Fiona H., Barber, Bridget E., Grigg, Matthew J., William, Timothy, Good, Michael F., Doolan, Denise L., Engwerda, Christian R., Anstey, Nicholas M., McCarthy, James S. and Woodberry, Tonia (2017). Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulation. Scientific Reports, 7 (1) 2596. doi: 10.1038/s41598-017-02096-2
Zhang, Ping, Lee, Jason S., Gartlan, Kate H., Schuster, Iona S., Comerford, Iain, Varelias, Antiopi, Ullah, Md Ashik, Vuckovic, Slavica, Koyama, Motoko, Kuns, Rachel D., Locke, Kelly R., Beckett, Kirrilee J., Olver, Stuart D., Samson, Luke D., Montes de Oca, Marcela, de Labastida Rivera, Fabian, Clouston, Andrew D., Belz, Gabrielle T., Blazar, Bruce R., MacDonald, Kelli P., McColl, Shaun R., Thomas, Ranjeny, Engwerda, Christian R., Degli-Esposti, Mariapia A., Kallies, Axel, Tey, Siok-Keen and Hill, Geoffrey R. (2017). Eomesodermin promotes the development of Type-1 Regulatory T (TR1) cells. Science Immunology, 2 (10) eaah7152. doi: 10.1126/sciimmunol.aah7152
Lönnberg, Tapio, Svensson, Valentine, James, Kylie R., Fernandez-Ruiz, Daniel, Sebina, Ismail, Montandon, Ruddy, Soon, Megan S. F., Fogg, Lily G., Nair, Arya Sheela, Liligeto, Urijah N., Stubbington, Michael J. T., Ly, Lam-Ha, Bagger, Frederik Otzen, Zwiessele, Max, Lawrence, Neil D., Souza-Fonseca-Guimaraes, Fernando, Bunn, Patrick T., Engwerda, Christian R., Heath, William R., Billker, Oliver, Stegle, Oliver, Haque, Ashraful and Teichmann, Sarah A. (2017). Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFHfate bifurcation in malaria. Science Immunology, 2 (9) eaal2192, eaal2192. doi: 10.1126/sciimmunol.aal2192
De Oca, Marcela Montes, Good, Michael F., McCarthy, James S. and Engwerda, Christian R. (2016). The impact of established immunoregulatory networks on vaccine efficacy and the development of immunity to malaria. Journal of Immunology, 197 (12), 4518-4526. doi: 10.4049/jimmunol.1600619
Sebina, Ismail, James, Kylie R., Soon, Megan S. F., Fogg, Lily G., Best, Shannon E., Labastida Rivera, Fabian de, Montes de Oca, Marcela, Amante, Fiona H., Thomas, Bryce S., Beattie, Lynette, Souza-Fonseca-Guimaraes, Fernando, Smyth, Mark J., Hertzog, Paul J., Hill, Geoffrey R., Hutloff, Andreas, Engwerda, Christian R. and Haque, Ashraful (2016). IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection. PLoS Pathogens, 12 (11) e1005999, e1005999. doi: 10.1371/journal.ppat.1005999
Navarro, Severine, Pickering, Darren A., Ferreira, Ivana B., Jones, Linda, Ryan, Stephanie, Troy, Sally, Leech, Andrew, Hotez, Peter J., Zhan, Bin, Laha, Thewarach, Prentice, Roger, Sparwasser, Tim, Croese, John, Engwerda, Christian R., Upham, John W., Julia, Valerie, Giacomin, Paul R. and Loukas, Alex (2016). Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Science Translational Medicine, 8 (362) 362ra143, 362ra143-362ra143. doi: 10.1126/scitranslmed.aaf8807
de Oca, Marcela Montes, Kumar, Rajiv, Rivera, Fabian de Labastida, Amante, Fiona H., Sheel, Meru, Faleiro, Rebecca J., Bunn, Patrick T., Best, Shannon E., Beattie, Lynette, Ng, Susanna S., Edwards, Chelsea L., Boyle, Glen M., Price, Ric N., Anstey, Nicholas M., Loughland, Jessica R., Burel, Julie, Doolan, Denise L., Haque, Ashraful, McCarthy, James S. and Engwerda, Christian R. (2016). Type I interferons regulate immune responses in humans with blood-stage Plasmodium falciparum infection. Cell Reports, 17 (2), 399-412. doi: 10.1016/j.celrep.2016.09.015
Beattie, Lynette, Sawtell, Amy, Mann, Jason, Frame, Teija C. M., Teal, Bianca, Rivera, Fabian de Labastida, Brown, Najmeeyah, Walwyn-Brown, Katherine, Moore, John W. J., MacDonald, Sandy, Lim, Eng-Kiat, Dalton, Jane E., Engwerda, Christian R., MacDonald, Kelli P. and Kaye, Paul M. (2016). Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions. Journal of Hepatology, 65 (4), 758-768. doi: 10.1016/j.jhep.2016.05.037
Le Texier, Laetitia, Lineburg, Katie E., Cao, Benjamin, McDonald-Hyman, Cameron, Leveque-El Mouttie, Lucie, Nicholls, Jemma, Melino, Michelle, Nalkurthi, Blessy C., Alexander, Kylie A., Teal, Bianca, Blake, Stephen J., Souza-Fonseca-Guimaraes, Fernando, Engwerda, Christian R., Kuns, Rachel D., Lane, Steven W., Teng, Michele, Teh, Charis, Gray, Daniel, Clouston, Andrew D., Nilsson, Susan K., Blazar, Bruce R., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2016). Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease. JCI Insight, 1 (15) e86850, e86850. doi: 10.1172/jci.insight.86850
Singh, Neetu, Kumar, Rajiv, Engwerda, Christian, Sacks, David, Nylen, Susanne and Sundar, Shyam (2016). Tumor necrosis factor alpha neutralization has no direct effect on parasite burden, but causes impaired IFN-γ production by spleen cells from human visceral leishmaniasis patients. Cytokine, 85, 184-90. doi: 10.1016/j.cyto.2016.06.013
Kho, Steven, Marfurt, Jutta, Handayuni, Irene, Pava, Zuleima, Noviyanti, Rintis, Kusuma, Andreas, Piera, Kim A, Burdam, Faustina H, Kenangalem, Enny, Lampah, Daniel A, Engwerda, Christian R, Poespoprodjo, Jeanne R, Price, Ric N, Anstey, Nicholas M, Minigo, Gabriela and Woodberry, Tonia (2016). Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection. Malaria Journal, 15 (1) 328. doi: 10.1186/s12936-016-1382-7
Loughland, Jessica R., Minigo, Gabriela, Burel, Julie, Tipping, Peta E., Piera, Kim A., Amante, Fiona H., Engwerda, Christian R., Good, Michael F., Doolan, Denise L., Anstey, Nicholas M., McCarthy, James S. and Woodberry, Tonia (2016). Profoundly reduced CD1c+ myeloid dendritic cell HLA-DR and CD86 expression and increased tumor necrosis factor production in experimental human blood-stage malaria infection. Infection and Immunity, 84 (5), 1403-1412. doi: 10.1128/IAI.01522-15
Faleiro, Rebecca J., Kumar, Rajiv, Bunn, Patrick T., Singh, Neetu, Chauhan, Shashi Bhushan, Sheel, Meru, Amante, Fiona H., Montes de Oca, Marcela, Edwards, Chelsea L., Ng, Susanna S., Best, Shannon E., Haque, Ashraful, Beattie, Lynette, Hafner, Louise M., Sacks, David, Nylen, Susanne, Sundar, Shyam and Engwerda, Christian R. (2016). Combined immune therapy for the treatment of visceral leishmaniasis. PLoS Neglected Tropical Diseases, 10 (2) e0004415, 1-21. doi: 10.1371/journal.pntd.0004415
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Montes de Oca, Marcela, Kumar, Rajiv, de Labastida Rivera, Fabian, Amante, Fiona H., Sheel, Meru, Faleiro, Rebecca J., Bunn, Patrick T., Best, S.E., Beattie, Lynette, Ng, Susanna S., Edwards, Chelsea L., Muller, Werner, Cretney, Erika, Nutt, Stephen L., Smyth, Mark J., Haque, Ashraful, Hill, Geoffrey R., Sundar, Shyam, Kallies, Axel and Engwerda, Christian R. (2016). Blimp-1-dependent IL-10 production by Tr1 cells regulates TNF-mediated tissue pathology. PLoS Pathogens, 12 (1) e1005398, 1-21. doi: 10.1371/journal.ppat.1005398
De, Sai Lata, Stanisic, Danielle I., Rivera, Fabian, Batzloff, Michael R., Engwerda, Christian and Good, Michael F. (2016). Plasmodium berghei bio-burden correlates with parasite lactate dehydrogenase: application to murine Plasmodium diagnostics. Malaria Journal, 15 (1) 3. doi: 10.1186/s12936-015-1027-2
Sheel, Meru, Beattie, Lynette, Frame, Teija C. M., Rivera, Fabian de Labastida, Faleiro, Rebecca J., Bunn, Patrick T., de Oca, Marcela Montes, Edwards, Chelsea L., Ng, Susanna S., Kumar, Rajiv, Amante, Fiona H., Best, Shannon E., McColl, Shaun R., Varelias, Antiopi, Kuns, Rachel D., MacDonald, Kelli P. A., Smyth, Mark J., Haque, Ashraful, Hill, Geoff R. and Engwerda, Christian R. (2015). IL-17A-Producing gamma delta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver. Journal of Immunology, 195 (12), 5707-5717. doi: 10.4049/jimmunol.1501046
Koyama, Motoko, Cheong, Melody, Markey, Kate A., Gartlan, Kate H., Kuns, Rachel D., Locke, Kelly R., Lineburg, Katie E., Teal, Bianca E., Leveque-El Mouttie, Lucie, Bunting, Mark D., Vuckovic, Slavica, Zhang, Ping, Teng, Michele W. L., Varelias, Antiopi, Tey, Siok-Keen, Wockner, Leesa F., Engwerda, Christian R., Smyth, Mark J., Belz, Gabrielle T., McColl, Shaun R., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2015). Donor colonic CD103(+) dendritic cells determine the severity of acute graft-versus-host disease. Journal of Experimental Medicine, 212 (8), 1303-1321. doi: 10.1084/jem.20150329
Engwerda, Christian R. and Matlashewski, Greg (2015). Development of Leishmania vaccines in the era of visceral leishmaniasis elimination. Transactions of the Royal Society of Tropical Medicine and Hygiene, 109 (7), 423-424. doi: 10.1093/trstmh/trv039
Matar, Caline G., Anthony, Neil R., O’Flaherty, Brigid M., Jacobs, Nathan T., Priyamvada, Lalita, Engwerda, Christian R., Speck, Samuel H. and Lamb, Tracey J. (2015). Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity. PLoS Pathogens, 11 (5) e1004858, e1004858. doi: 10.1371/journal.ppat.1004858
Edwards, Chelsea L., Zhang, Vivian, Werder, Rhiannon B., Best, Shannon E., Sebina, Ismail, James, Kylie R., Faleiro, Rebecca J., Rivera, Fabian de Labastida, Amante, Fiona H., Engwerda, Christian R., Phipps, Simon and Haque, Ashraful (2015). Coinfection with blood-stage plasmodium promotes systemic type I interferon production during pneumovirus infection but impairs inflammation and viral control in the lung. Clinical and Vaccine Immunology, 22 (5), 477-483. doi: 10.1128/CVI.00051-15
Croese, John, Giacomin, Paul, Navarro, Severine, Clouston, Andrew, McCann, Leisa, Dougall, Annette, Ferreira, Ivana, Susianto, Atik, O'Rourke, Peter, Howlett, Mariko, McCarthy, James, Engwerda, Christian, Jones, Dianne and Loukas, Alex (2015). Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease. Journal of Allergy and Clinical Immunology, 135 (2), 508-516.e5. doi: 10.1016/j.jaci.2014.07.022
Edwards, Chelsea L., Best, Shannon E., Gun, Sin Yee, Claser, Carla, James, Kylie R., de Oca, Marcela M., Sebina, Ismail, Rivera, Fabian de Labastida, Amante, Fiona H., Hertzog, Paul J., Engwerda, Christian R., Renia, Laurent and Haque, Ashraful (2015). Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection. European Journal of Immunology, 45 (1), 130-141. doi: 10.1002/eji.201444824
Kho, Steven, Marfurt, Jutta, Noviyanti, Rintis, Kusuma, Andreas, Piera, Kim A., Burdam, Faustina H., Kenangalem, Enny, Lampah, Daniel A., Engwerda, Christian R., Poespoprodjo, Jeanne R., Price, Ric N., Anstey, Nicholas M., Minigo, Gabriela and Woodberry, Tonia (2015). Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in Asymptomatic Plasmodium falciparum and P. vivax infection. Infection and Immunity, 83 (8), 3224-3232. doi: 10.1128/IAI.00226-15
Alexander K.A., Flynn R., Lineburg K.E., Kuns R.D., Teal B.E., Olver S.D., Lor M., Raffelt N.C., Koyama M., Leveque L., Le Texier L., Melino M., Markey K.A., Varelias A., Engwerda C., Serody J.S., Janela B., Ginhoux F., Clouston A.D., Blazar B.R., Hill G.R. and MacDonald K.P.A. (2014). CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease. Journal of Clinical Investigation, 124 (10), 4266-4280. doi: 10.1172/JCI75935
Haque, Ashraful, Best, Shannon E., De Oca, Marcela Montes, James, Kylie R., Ammerdorffer, Anne, Edwards, Chelsea L., De Labastida Rivera, Fabian, Amante, Fiona H., Bunn, Patrick T., Sheel, Meru, Sebina, Ismail, Koyama, Motoko, Varelias, Antiopi, Hertzog, Paul J., Kalinke, Ulrich, Gun, Sin Yee, Renia, Laurent, Ruedl, Christiane, MacDonald, Kelli P.A., Hill, Geoffrey R. and Engwerda, Christian R. (2014). Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity. Journal of Clinical Investigation, 124 (6), 2483-2496. doi: 10.1172/JCI70698
Lau, Lei Shong, Fernandez-Ruiz, Daniel, Mollard, Vanessa, Sturm, Angelika, Neller, Michelle A., Cozijnsen, Anton, Gregory, Julia L., Davey, Gayle M., Jones, Claerwen M., Lin, Yi-Hsuan, Haque, Ashraful, Engwerda, Christian R., Nie, Catherine Q., Hansen, Diana S., Murphy, Kenneth M., Papenfuss, Anthony T., Miles, John J., Burrows, Scott R., de Koning-Ward, Tania, McFadden, Geoffrey I., Carbone, Francis R., Crabb, Brendan S. and Heath, William R. (2014). CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria. PLoS Pathogens, 10 (5) e1004135, e1004135. doi: 10.1371/journal.ppat.1004135
Bunn, Patrick T., Stanley, Amanda C., de Labastida Rivera, Fabian, Mulherin, Alexander, Sheel, Meru, Alexander, Clare E., Faleiro, Rebecca J., Amante, Fiona H., De Oca, Marcela Montes, Best, Shannon E., James, Kylie R., Kaye, Paul M., Haque, Ashraful and Engwerda, Christian R. (2014). Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection. Journal of Immunology, 192 (8), 3709-3718. doi: 10.4049/jimmunol.1300768
Kumar, Rajiv and Engwerda, Christian (2014). Vaccines to prevent leishmaniasis. Clinical and Translational Immunology, 3 (3) e13. doi: 10.1038/cti.2014.4
Khoury, David S., Cromer, Deborah, Best, Shannon E., James, Kylie R., Kim, Peter S., Engwerda, Christian R., Haque, Ashraful and Davenport, Miles P. (2014). Effect of mature blood-stage Plasmodium parasite sequestration on pathogen biomass in mathematical and in vivo models of malaria. Infection and Immunity, 82 (1), 212-220. doi: 10.1128/IAI.00705-13
Haque, Ashraful and Engwerda, Christian (2014). Hepatocytes break the silence during liver-stage malaria. Nature Medicine, 20 (1), 17-19. doi: 10.1038/nm.3446
Simerska, Pavla, Suksamran, Tittaya, Ziora, Zyta Maria, Rivera, Fabian de Labastida, Engwerda, Christian and Toth, Istvan (2014). Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses. Vaccine, 32 (37), 4743-4750. doi: 10.1016/j.vaccine.2014.06.049
Faleiro, Rebecca J., Kumar, Rajiv, Hafner, Louise M. and Engwerda, Christian R. (2014). Immune Regulation during Chronic Visceral Leishmaniasis. PLoS Neglected Tropical Diseases, 8 (7) e2914, e2914. doi: 10.1371/journal.pntd.0002914
Engwerda, Christian R., Ng, Susanna S. and Bunn, Patrick T. (2014). The regulation of CD4+ T cell responses during protozoan infections. Frontiers in Immunology, 5 (OCT) 498. doi: 10.3389/fimmu.2014.00498
Pinzon-Charry, Alberto, Woodberry, Tonia, Kienzle, Vivian, McPhun, Virginia, Minigo, Gabriela, Lampah, Daniel A., Kenangalem, Enny, Engwerda, Christian, LÓpez, J. Alejandro, Anstey, Nicholas M. and Good, Michael F. (2013). Apoptosis and dysfunction of blood dendritic cells in patients with falciparum and vivax malaria. Journal of Experimental Medicine, 210 (8), 1635-1646. doi: 10.1084/jem.20121972
Good, Michael F., Reiman, Jennifer M., Rodriguez, I. Bibiana, Ito, Koichi, Yanow, Stephanie K., El-Deeb, Ibrahim M., Batzloff, Michael R., Stanisic, Danielle I., Engwerda, Christian, Spithill, Terry, Hoffman, Stephen L., Lee, Moses and McPhun, Virginia (2013). Cross-species malaria immunity induced by chemically attenuated parasites. Journal of Clinical Investigation, 123 (8), 3353-3362. doi: 10.1172/JCI66634
De Oca, Marcela Montes, Engwerda, Christian and Haque, Ashraful (2013). Plasmodium berghei ANKA (PbA) infection of C57BL/6J mice: A model of severe malaria. Methods in Molecular Biology, 1031, 203-213. doi: 10.1007/978-1-62703-481-4_23
Handoko, Herlina Y., Rodero, Mathieu P., Boyle, Glen M., Ferguson, Blake, Engwerda, Christian, Hill, Geoff, Muller, H. Konrad, Khosrotehrani, Kiarash and Walker, Graeme J. (2013). UVB-induced melanocyte proliferation in neonatal mice driven by CCR2-independent recruitment of Ly6c(low)MHCII(hi) macrophages. Journal of Investigative Dermatology, 133 (7), 1803-1812. doi: 10.1038/jid.2013.9
Sheel, Meru and Engwerda, Christian R. (2013). Corrigendum to: The diverse roles of monocytes in inflammation caused by protozoan parasitic diseases [Int. J. Parasitol. 41 (2012) 1311-1321]. Trends in Parasitology, 29 (6). doi: 10.1016/j.pt.2013.03.010
Cromer, Deborah, Best, Shannon E., Engwerda, Christian, Haque, Ashraful and Davenport, Miles (2013). Where have all the parasites gone? Modelling early malaria parasite sequestration dynamics. PLoS ONE, 8 (2) e55961, e55961. doi: 10.1371/journal.pone.0055961
Engwerda, Christian R and Kumar, Rajiv (2013). Mast cells fuel the fire of malaria immunopathology. Nature Medicine, 19 (6), 672-674. doi: 10.1038/nm.3227
Engwerda, Christian R. and Good, Michael F. (2012). Immunology: Platelets kill the parasite within. Science, 338 (6112), 1304-1305. doi: 10.1126/science.1232439
Engwerda, Christian R., Minigo, Gabriela, Amante, Fiona H. and McCarthy, James S. (2012). Experimentally induced blood stage malaria infection as a tool for clinical research. Trends in Parasitology, 28 (11), 515-521. doi: 10.1016/j.pt.2012.09.001
Sheel, Meru and Engwerda, Christian R. (2012). The diverse roles of monocytes in inflammation caused by protozoan parasitic diseases. Trends in Parasitology, 28 (10), 408-416. doi: 10.1016/j.pt.2012.07.008
Woodberry, Tonia, Minigo, Gabriela, Piera, Kim A., Amante, Fiona H., Pinzon-Charry, Alberto, Good, Michael F., Lopez, J. Alejandro, Engwerda, Christian R., McCarthy, James S. and Anstey, Nicholas M. (2012). Low-level plasmodium falciparum blood-stage infection causes dendritic cell apoptosis and dysfunction in healthy volunteers. Journal of Infectious Diseases, 206 (3), 333-340. doi: 10.1093/infdis/jis366
Robb, R.J., Lineburg, K.E., Kuns, R.D., Wilson, Y.A., Raffelt, N.C., Olver, S.D., Varelias, A., Alexander, K.A., Teal, B.E., Sparwasser, T., Hammerling, G.J., Markey, K.A., Koyama, M., Clouston, A.D., Engwerda, C.R., Hill, G.R. and MacDonald, K.P.A. (2012). Identification and expansion of highly suppressive CD8 +FoxP3 + regulatory T cells after experimental allogeneic bone marrow transplantation. Blood, 119 (24), 5898-5908. doi: 10.1182/blood-2011-12-396119
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Gaze, Soraya, McSorley, Henry J., Daveson, James, Jones, Di, Bethony, Jeffrey M., Oliveira, Luciana M., Speare, Richard, McCarthy, James S., Engwerda, Christian R., Croese, John and Loukas, Alex (2012). Characterising the mucosal and systemic immune responses to experimental human hookworm infection. PLoS Pathogens, 8 (2) e1002520, e1002520. doi: 10.1371/journal.ppat.1002520
Ali, Nahid, Mekuria, Asrat Hailu, Requena, Jose M. and Engwerda, Christian (2012). Immunity to visceral leishmaniasis. Journal of Tropical Medicine 780809. doi: 10.1155/2012/780809
Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Raffelt, Neil C., Wilson, Yana A., Don, Alistair L. J., Lineburg, Katie E., Cheong, Melody, Robb, Renee J., Markey, Kate A., Varelias, Antiopi, Malissen, Bernard, Hammerling, Gunter J., Clouston, Andrew D., Engwerda, Christian R., Bhat, Purnima, MacDonald, Kelli P. A. and Hill, Geoffrey R. (2012). Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease. Nature Medicine, 18 (1), 135-142. doi: 10.1038/nm.2597
Stanley, Amanda C., Rivera, Fabian de Labastida, Haque, Ashraful, Sheel, Meru, Zhou, Yonghong, Amante, Fiona H., Bunn, Patrick T., Randall, Louise M., Pfeffer, Klaus, Scheu, Stefanie, Hickey, Michael J., Saunders, Bernadette M., Ware, Carl, Hill, Geoff R., Tamada, Koji, Kaye, Paul M. and Engwerda, Christian R. (2011). Critical roles for LIGHT and its Receptors in Generating T cell-mediated immunity during Leishmania donovani infection. PLoS Pathogens, 7 (10) e1002279, 1-15. doi: 10.1371/journal.ppat.1002279
McSorley, Henry J., Gaze, Soraya, Daveson, James, Jones, Dianne, Anderson, Robert P., Clouston, Andrew, Ruyssers, Nathalie E., Speare, Richard, McCarthy, James S., Engwerda, Christian R., Croese, John and Loukas, Alex (2011). Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection. PLoS One, 6 (9) e24092, e24092-1-e24092-7. doi: 10.1371/journal.pone.0024092
Haque, Ashraful, Best, Shannon E., Ammerdorffer, Anne, Desbarrieres, Laure, de Oca, Marcela Montes, Amante, Fiona H., Rivera, Fabian de Labastida, Hertzog, Paul, Boyle, Glen M., Hill, Geoffrey R. and Engwerda, Christian R. (2011). Type I interferons suppress CD4+ T-cell-dependent parasite control during blood-stage Plasmodium infection. European Journal of Immunology, 41 (9), 2688-2698. doi: 10.1002/eji.201141539
Haque, Ashraful, Best, Shannon E., Unosson, Klara, Amante, Fiona H., de Labastida, Fabian, Anstey, Nicholas M., Karupiah, Gunasegaran, Smyth, Mark J., Heath, William R. and Engwerda, Christian R. (2011). Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria. Journal of Immunology, 186 (11), 6148-6156. doi: 10.4049/jimmunol.1003955
Haque, Ashraful, Best, Shannon E., Amante, Fiona H., Ammerdorffer, Anne, de Labastida, Fabian, Pereira, Tamara, Ramm, Grant A. and Engwerda, Christian R. (2011). High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8+ T cell-mediated immune pathology. Infection and Immunity, 79 (5), 1882-1888. doi: 10.1128/IAI.01210-10
Haque, Ashraful and Engwerda, Christian R. (2011). An antioxidant link between sickle cell disease and severe malaria. Cell, 145 (3), 335-336. doi: 10.1016/j.cell.2011.04.004
Amante, Fiona H., Engwerda, Christian R. and Good, Michael F. (2011). Experimental asexual blood stage malaria immunity. Current Protocols in Essential Laboratory Techniques, 2011 (SUPPL.93) 19.4. doi: 10.1002/0471142735.im1904s93
Good, Michael F. and Engwerda, Christian (2011). Defying malaria: Arming T cells to halt malaria. Nature Medicine, 17 (1), 49-51. doi: 10.1038/nm0111-49
Haque, Ashraful, Best, Shannon E., Amante, Fiona H., Mustafah, Seri, Desbarrieres, Laure, de Labastida, Fabian, Sparwasser, Tim, Hill, Geoffrey R. and Engwerda, Christian R. (2010). CD4+ natural regulatory T Cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PLoS Pathogens, 6 (12) e1001221, 1 - e1001221-14 - e1001221. doi: 10.1371/journal.ppat.1001221
Randall, Louise M. and Engwerda, Christian R. (2010). TNF family members and malaria: Old observations, new insights and future directions. Experimental Parasitology, 126 (3), 326-331. doi: 10.1016/j.exppara.2010.04.016
Randall, LM, Kenangalem, E, Lampah, DA, Tjitra, E, Mwaikambo, ED, Handojo, T, Piera, KA, Zhao, ZZ, Rivera, FD, Zhou, YH, McSweeney, KM, Le, LE, Amante, FH, Haque, A, Stanley, AC, Woodberry, T, Salwati, E, Granger, DL, Hobbs, MR, Price, RN, Weinberg, JB, Montgomery, GW, Anstey, NM and Engwerda, CR (2010). A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults. Malaria Journal, 9 (1) 302, 302-1-302-9. doi: 10.1186/1475-2875-9-302
Engwerda, Christian R. and Good, Michael F. (2010). A novel pathway of haematopoiesis revealed after experimental malaria infection. Immunology and Cell Biology, 88 (7), 692-694. doi: 10.1038/icb.2010.89
Amante, FH, Haque, A, Stanley, AC, Rivera, FD, Randall, LM, Wilson, YA, Yeo, G, Pieper, C, Crabb, BS, de Koning-Ward, TF, Lundie, RJ, Good, MF, Pinzon-Charry, A, Pearson, MS, Duke, MG, McManus, DP, Loukas, A, Hill, GR and Engwerda, CR (2010). Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria. Journal of Immunology, 185 (6), 3632-3642. doi: 10.4049/jimmunol.1000944
Pinzon-Charry, A, McPhun, V, Kienzle, V, Hirunpetcharat, C, Engwerda, C, McCarthy, J and Good, MF (2010). Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice. Journal of Clinical Investigation, 120 (8), 2967-2978. doi: 10.1172/JCI39222
Engwerda, C. R. and Meeusen, E. N. (2010). Parasites and the immune system: A perspective from down under. Parasite Immunology, 32 (8), 529-531. doi: 10.1111/j.1365-3024.2010.01234.x
Randall, Louise M., Kenangalem, Enny, Lampah, Daniel A., Tjitra, Emiliana, Mwaikambo, Esther D., Handojo, Tjandra, Piera, Kim A., Zhao, Zhen Zhen, Rivera, Fabian de Labastida, Zhou, Yonghong, McSweeney, Karli M., Le, Lien, Amante, Fiona H., Haque, Ashraful, Stanley, Amanda C., Woodberry, Tonia, Salwati, Ervi, Granger, Donald L., Hobbs, Maurine R., Price, Ric N., Weinberg, J. Brice, Montgomery, Grant W., Anstey, Nicholas M. and Engwerda, Christian R. (2010). Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans. Journal of Infectious Diseases, 202 (1), 117-124. doi: 10.1086/653125
Hunt, Nicholas H., Grau, Georges E., Engwerda, Christian, Barnum, Scott R., van der Heyde, Henri, Hansen, Diana S., Schofield, Louis and Golenser, Jacob (2010). Murine cerebral malaria: The whole story. Trends in Parasitology, 26 (6), 272-274. doi: 10.1016/j.pt.2010.03.006
Haque, Ashraful, Stanley, Amanda C., Amante, Fiona H., de Labastida Rivera, Fabian, Zhou, YongHong, Kuns, Rachel D., Yardley, Vanessa, Sakaguchi, Shimon, Hill, Geoffrey R. and Engwerda, Christian R. (2010). Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity. Journal of Immunology, 184 (5), 2583-2592. doi: 10.4049/jimmunol.0903080
Markey, KA, Burman, AC, Banovic, T, Kuns, RD, Raffelt, NC, Rowe, V, Olver, SD, Don, ALJ, Morris, ES, Pettit, AR, Wilson, YA, Robb, RJ, Randall, LM, Korner, H, Engwerda, CR, Clouston, AD, MacDonald, KPA and Hill, GR (2010). Soluble lymphotoxin is an important effector molecule in GVHD and GVL. Blood, 115 (1), 122-132. doi: 10.1182/blood-2009-01-199927
Koerner, Heinrich and Engwerda, Christian (2009). ASI 2009: Immunology "down under". European Journal of Immunology, 39 (8), 1989-1990. doi: 10.1002/eji.200990044
Woodberry, Tonia, Pinzon-Charry, Alberto, Piera, Kim A., Panpisutchai, Yawalak, Engwerda, Christian R., Doolan, Denise L., Salwati, Ervi, Kenangalem, Enny, Tjitra, Emiliana, Price, Ric N., Good, Michael F. and Anstey, Nicholas M. (2009). Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria. Malaria Journal, 8 (1) 122, 122.1-122.10. doi: 10.1186/1475-2875-8-122
Gabriela Minigo, Tonia Woodberry, Kim A. Piera, Ervi Salwati, Emiliana Tjitra, Enny Kenangalem, Ric N. Price, Christian R. Engwerda, Nicholas M. Anstey and Magdalena Plebanski (2009). Parasite-Dependent Expansion of TNF Receptor II–Positive Regulatory T Cells with Enhanced Suppressive Activity in Adults with Severe Malaria. PLoS Pathogens, 5 (4) e1000402, e1000402.1-e1000402.10. doi: 10.1371/journal.ppat.1000402
Catherine Q. Nie, Nicholas J. Bernard, M. Ursula Norman, Fiona H. Amante, Rachel J. Lundie, Brendan S. Crabb, William R. Heath, Christian R. Engwerda, Michael J. Hickey, Louis Schofield and Diana S. Hansen (2009). IP-10-Mediated T Cell Homing Promotes Cerebral Inflammation over Splenic Immunity to Malaria Infection. PLoS Pathogens, 5 (4) ARTN e1000369, e1000369. doi: 10.1371/journal.ppat.1000369
Edward S Morris, Kelli P A MacDonald, Rachel D Kuns, Helen M Morris, Tatjana Banovic, Alistair L J Don, Vanessa Rowe, Yana A Wilson, Neil C Raffelt, Christian R Engwerda, Angela C Burman, Kate A Markey, Dale I Godfrey, Mark J Smyth and Geoffrey R Hill (2009). Induction of natural killer T cell–dependent alloreactivity by administration of granulocyte colony–stimulating factor after bone marrow transplantation. Nature Medicine, 15 (4), 436-441. doi: 10.1038/nm.1948
Tatjana Banovic, Kate A. Markey, Rachel D. Kuns, Stuart D. Olver, Neil C. Raffelt, Alistair L. Don, Mariapia A. Degli-Esposti, Christian R. Engwerda, Kelli P. A. MacDonald and Geoffrey R. Hill (2009). Graft-versus-Host Disease Prevents the Maturation of Plasmacytoid Dendritic Cells. Journal of Immunology, 182 (2), 912-920. doi: 10.4049/jimmunol.182.2.912
Randall, Louise M., Amante, Fiona H., Zhou, Yonghong, Stanley, Amanda C., Haque, Ashraful, Rivera, Fabian, Pfeffer, Klaus, Scheu, Stefanie, Hill, Geoff R., Tamada, Koji and Engwerda, Christian R. (2008). Cutting edge: Selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA. Journal of Immunology, 181 (11), 7458-7460. doi: 10.4049/jimmunol.181.11.7458
Beeson, James G., Osier, Faith H.A. and Engwerda, Christian R. (2008). Recent insights into humoral and cellular immune responses against malaria. Trends in Parasitology, 24 (12), 578-584. doi: 10.1016/j.pt.2008.08.008
Stanley, Amanda C., Dalton, Jane E., Rossotti, Susanna H., MacDonald, Kelli P., Zhou, Yonghong, Rivera, Fabian, Schroder, Wayne A., Maroof, Asher, Hill, Geoff R., Kaye, Paul M. and Engwerda, Christian R. (2008). VCAM-1 and VLA-4 modulate dendritic cell IL-12p40 production in experimental visceral leishmaniasis. PLoS Pathogens, 4 (9) e1000158, e1000158-1-e1000158-11. doi: 10.1371/journal.ppat.1000158
Engwerda, Christian R. and Good, Michael F. (2008). Disarming the malaria parasite. Nature Medicine, 14 (9), 912-913. doi: 10.1038/nm0908-912
Randall, Louise M., Amante, Fiona H., McSweeney, Karli A., Zhou, Yonghong, Stanley, Amanda C., Haque, Ashraful, Jones, Malcolm K., Hill, Geoff R., Boyle, Glen M. and Engwerda, Christian R. (2008). Common strategies to prevent and modulate experimental cerebral malaria in different susceptible mouse strains. Infection and Immunity, 76 (7), 3312-3320. doi: 10.1128/IAI.01475-07
Seach, Natalie, Ueno, Tomoo, Fletcher, Anne L., Lowen, Tamara, Mattesich, Monika, Engwerda, Christian R., Scott, Hamish S., Ware, Carl F., Chidgey, Ann P., Gray, Daniel H. D. and Boyd, Richard L. (2008). The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells. Journal of Immunology, 180 (8), 5384-5392. doi: 10.4049/jimmunol.180.8.5384
Amante, Fiona H., Engwerda, Christian R., Godfrey, Dale I., Haque, Ashraful, Hill, Geoff R., Pellicci, Daniel G., Randall, Louise M., Smyth, Mark J., Stanley, Amanda C. and Zhou, Yonghong (2008). Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis. PLoS Pathogens, 4 (2), e1000028-1-e1000028-13. doi: 10.1371/journal.ppat.1000028
Zhao, Zhen Zhen, Nyholt, Dale R., Le, Lien, Thomas, Shane, Engwerda, Christian, Randall, Louise, Treloar, Susan A. and Montgomery, Grant W. (2007). Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample. Human Reproduction, 22 (9), 2389-2397. doi: 10.1093/humrep/dem182
Burman, Angela C., Banovic, Tatjana, Kuns, Rachel D., Clouston, Andrew D., Stanley, Amanda C., Morris, Edward S., Rowe, Vanessa, Bofinger, Helen, Skoczylas, Renae, Raffelt, Neil, Fahy, Olivier, McColl, Shaun R., Engwerda, Christian R., McDonald, Kelli P. A. and Hill, Geoffrey R. (2007). IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood, 110 (3), 1064-1072. doi: 10.1182/blood-2006-12-063982
Amante, Fiona H., Stanley, Amanda C., Randall, Louise M., Zhou, Yonghong, Haque, Ashraful, McSweeney, Karli, Waters, Andrew P., Janse, Chris J., Good, Michael F., Hill, Geoff R. and Engwerda, Christian R. (2007). A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria. American Journal of Pathology, 171 (2), 548-559. doi: 10.2353/ajpath.2007.061033
deWalick, Saskia, Amante, Fiona H., McSweeney, Karli A., Randall, Louise M., Stanley, Amanda C., Haque, Ashraful, Kuns, Rachel D., MacDonald, Kelli P. A., Hill, Geoff R. and Engwerda, Christian R. (2007). Cutting Edge: Conventional Dendritic Cells are the Critical APC Required for the Induction of Experimental Cerebral Malaria. Journal of Immunology, 178 (10), 6033-6037. doi: 10.4049/jimmunol.178.10.6033
Clark, K., Kulk, N., Amante, F., Haque, A. and Engwerda, C. (2007). Lymphotoxin alpha and tumour necrosis factor are not required for control of parasite growth, but differentially regulate cytokine production during Plasmodium chabaudi chabaudi AS infection. Parasite Immunology, 29 (3), 153-158. doi: 10.1111/j.1365-3024.2006.00930.x
Stanley, Amanda C. and Engwerda, Christian R. (2007). Balancing immunity and pathology in visceral leishmaniasis. Immunology and Cell Biology, 85 (2), 138-147. doi: 10.1038/sj.icb7100011
Beattie, Lynette, Engwerda, Christian R., Wykes, Michelle and Good, Michael F. (2006). CD8+ T lymphocyte-mediated loss of marginal metallophilic macrophages following infection with Plasmodium chabaudi chabaudi AS. Journal of Immunology, 177 (4), 2518-2526. doi: 10.4049/jimmunol.177.4.2518
Hassan, Mohammed F., Zhang, Yaobi, Engwerda, Christian R., Kaye, Paul M., Sharp, Hannah and Bickle, Quentin D. (2006). The Schistosoma mansoni hepatic egg granuloma provides a favorable microenvironment for sustained growth of Leishmania donovani. American Journal of Pathology, 169 (3), 943-953. doi: 10.2353/ajpath.2006.051319
Engwerda, Christian R. and Good, Michael F. (2005). Interactions between malaria parasites and the host immune system. Current Opinion in Immunology, 17 (4), 381-387. doi: 10.1016/j.coi.2005.05.010
Good, Michael F., Xu, Huji, Wykes, Michelle and Engwerda, Christian R. (2005). Development and regulation of cell-mediated immune responses to the blood stages of malaria: Implications for vaccine research. Annual Review of Immunology, 23 (1), 66-69. doi: 10.1146/annurev.immunol.23.021704.115638
Engwerda, Christian R., Beattie, Lynette and Amante, Fiona H. (2005). The importance of the spleen in malaria. Trends in Parasitology, 21 (2), 75-80. doi: 10.1016/j.pt.2004.11.008
Engwerda, C., Belnoue, E., Gruner, A. C. and Renia, L. (2005). Experimental models of cerebral malaria. Current Topics in Microbiology and Immunology, 297, 103-143. doi: 10.1007/3-540-29967-X_4
Engwerda, Christian R., Ato, Manabu, Stäger, Simona, Alexander, Clare E., Stanley, Amanda C. and Kaye, Paul M. (2004). Distinct roles for lymphotoxin-alpha and tumor necrosis factor in the control of leishmania donovani infection. American Journal of Pathology, 165 (6), 2123-2133. doi: 10.1016/S0002-9440(10)63262-2
Jones, Malcolm K., Randall, Louise M., McManus, Donald P. and Engwerda, Christian R. (2004). Laser microdissection microscopy in parasitology: microscopes meet thermocyclers. Trends In Parasitology, 20 (11), 502-506. doi: 10.1016/j.pt.2004.08.011
Engwerda, Christian R., Ato, Manabu and Kaye, Paul M. (2004). Macrophages, pathology and parasite persistence in experimental visceral leishmaniasis. Trends in Parasitology, 20 (11), 524-530. doi: 10.1016/j.pt.2004.08.009
Kaye, Paul M., Svensson, Mattias, Ato, Manabu, Maroof, Asher, Polley, Rosalind, Stager, Simona, Zubairi, Soombul and Engwerda, Christian R. (2004). The immunopathology of experimental visceral leishmaniasis. Immunological Reviews, 201 (1), 239-253. doi: 10.1111/j.0105-2896.2004.00188.x
Ato, Manabu, Stäger, Simona, Engwerda, Christian R. and Kaye, Paul M. (2002). Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis. Nature Immunology, 3 (12), 1185-1191. doi: 10.1038/ni861
Engwerda, Christian R., Mynott, Tracey L., Sawhney, Sanjeet, De Souza, J. Brian, Bickle, Quentin D. and Kaye, Paul M. (2002). Locally up-regulated lymphotoxin α, not systemic tumor necrosis factor α, is the principle mediator of murine cerebral malaria. Journal of Experimental Medicine, 195 (10), 1371-1377. doi: 10.1084/jem.20020128
Engwerda, Christian R., Ato, Manabu, Cotterell, Sara E. J., Mynott, Tracey L., Tschannerl, Asiya, Gorak-Stolinska, Patricia M. A. and Kaye, Paul M. (2002). A role for tumor necrosis factor-α in remodeling the splenic marginal zone during Leishmania donovani infection. American Journal of Pathology, 161 (2), 429-437. doi: 10.1016/S0002-9440(10)64199-5
Tan, T. H.P., Edgerton, S. A.V., Kumari, R., McAlister, M. S.B., Rowe, S. M., Nagl, S., Pearl, L. H., Selkirk, M. E., Bianco, A. E., Totty, N. F., Engwerda, C., Gray, C. A. and Meyer, D. J. (2001). Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis. Biochemical Journal, 357 (2), 373-383. doi: 10.1042/0264-6021:3570373
Engwerda, Christian R., Andrew, Deborah, Murphy, Michaela and Mynott, Tracey L. (2001). Bromelain activates murine macrophages and natural killer cells in vitro. Cellular Immunology, 210 (1), 5-10. doi: 10.1006/cimm.2001.1793
Engwerda, Christian R., Andrew, Deborah, Ladhams, Andrew and Mynott, Tracey L. (2001). Bromelain modulates T cell and B cell immune responses in vitro and in vivo. Cellular Immunology, 210 (1), 66-75. doi: 10.1006/cimm.2001.1807
Alexander, Clare E., Kaye, Paul M. and Engwerda, Christian R. (2001). CD95 is required for the early control of parasite burden in the liver of Leishmania donovani-infected mice. European Journal of Immunology, 31 (4), 1199-1210. doi: 10.1002/1521-4141(200104)31:4<1199::AID-IMMU1199>3.0.CO;2-6
Smelt, Sara C., Cotterell, Sara E. J., Engwerda, Christian R. and Kaye, Paul M. (2000). B cell-deficient mice are highly resistant to Leishmania donovani infection, but develop neutrophil-mediated tissue pathology. Journal of Immunology, 164 (7), 3681-3688. doi: 10.4049/jimmunol.164.7.3681
Cotterell, Sara E. J., Engwerda, Christian R. and Kaye, Paul M. (2000). Enhanced hematopoietic activity accompanies parasite expansion in the spleen and bone marrow of mice infected with Leishmania donovani. Infection and Immunity, 68 (4), 1840-1848. doi: 10.1128/IAI.68.4.1840-1848.2000
Cotterell, Sara E. J., Engwerda, Christian R. and Kaye, Paul M. (2000). Leishmania donovani infection of bone marrow stromal macrophages selectively enhances myelopoiesis, by a mechanism involving GM-CSF and TNF-α. Blood, 95 (5), 1642-1651. doi: 10.1182/blood.v95.5.1642.005k10_1642_1651
Engwerda, Christian R. and Kaye, Paul M. (2000). Organ-specific immune responses associated with infectious disease. Immunology Today, 21 (2), 73-78. doi: 10.1016/S0167-5699(99)01549-2
Mynott, Tracey L., Ladhams, Andrew, Scarmato, Pierre and Engwerda, Christian R. (1999). Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells. Journal of Immunology, 163 (5), 2568-2575.
Cotterell, Sara E. J., Engwerda, Christian R. and Kaye, Paul M. (1999). Leishmania donovani infection initiates T cell-independent chemokine responses, which are subsequently amplified in a T cell-dependent manner. European Journal of Immunology, 29 (1), 203-214. doi: 10.1002/(SICI)1521-4141(199901)29:01<203::AID-IMMU203>3.0.CO;2-B
Murphy, Michaela L., Cotterell, Sara E. J., Gorak, Patricia M. A., Engwerda, Christian R. and Kaye, Paul M. (1998). Blockade of CTLA-4 enhances host resistance to the intracellular pathogen, Leishmania donovani. Journal of Immunology, 161 (8), 4153-4160.
Gorak, Patricia M. A., Engwerda, Christian R. and Kaye, Paul M. (1998). Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection. European Journal of Immunology, 28 (2), 687-695. doi: 10.1002/(SICI)1521-4141(199802)28:02<687::AID-IMMU687>3.0.CO;2-N
Engwerda, Christian R., Murphy, Michaela L., Cotterell, Sara E. J., Smelt, Sara C. and Kaye, Paul M. (1998). Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani. European Journal of Immunology, 28 (2), 669-680. doi: 10.1002/(SICI)1521-4141(199802)28:02<669::AID-IMMU669>3.0.CO;2-N
Murphy, Michaela L., Engwerda, Christian R., Gorak, Patricia M. A. and Kaye, Paul M. (1997). B7-2 Blockade Enhances T Cell Responses to Leishmania donovani. Journal of Immunology, 159 (9), 4460-4466.
Smelt, Sara C., Engwerda, Christian R., McCrossen, Maria and Kaye, Paul M. (1997). Destruction of Follicular Dendritic Cells during Chronic Visceral Leishmaniasis. Journal of Immunology, 158 (8), 3813-3821.
Engwerda, Christian R., Handwerger, Barry S. and Fox, Barbara S. (1996). An age-related decrease in rescue from T cell death following costimulation mediated by CD28. Cellular Immunology, 170 (1), 141-148. doi: 10.1006/cimm.1996.0144
Engwerda, Christian R., Fox, Barbara S. and Handwerger, Barry S. (1996). Cytokine production by T lymphocytes from young and aged mice. Journal of Immunology, 156 (10), 3621-3630.
Engwerda, Christian R., Smelt, Sara C. and Kaye, Paul M. (1996). An in vivo analysis of cytokine production during Leishmania donovani infection in scid mice. Experimental Parasitology, 84 (2), 195-202. doi: 10.1006/expr.1996.0105
Engwerda, C. R., Dale, C. J. and Sandeman, R. M. (1996). IgE, TNFα, IL1 β, IL4 and IFNγ gene polymorphisms in sheep selected for resistance to fleece rot and flystrike. International Journal for Parasitology, 26 (7), 787-791. doi: 10.1016/0020-7519(96)00053-7
Engwerda, Christian R., Handwerger, Barry S. and Fox, Barbara S. (1994). Aged T cells are hyporesponsive to costimulation mediated by CD28. Journal of Immunology, 152 (8), 3740-3747.
Engwerda, Christian R., Sandeman, Ruth A., Stuart, Simon J. and Sandeman, R.Mark (1992). Isolation and sequence of sheep immunoglobulin E heavy-chain complementary DNA. Veterinary Immunology and Immunopathology, 34 (1-2), 115-126. doi: 10.1016/0165-2427(92)90155-J
Engwerda, C. R. and Sandeman, R. M. (1992). The isolation and sequence of sheep interleukin 4. Mitochondrial DNA, 3 (2), 111-113. doi: 10.3109/10425179209034004
Conference Papers
Kumar, R., Engwerda, C. and Sundar, S. (2023). A molecular and immunological signature of IL-10 producing CD4+T cells in visceral leishmaniasis. International Congress on Infectious Diseases 2022, Kuala Lumpur, Malaysia, 17 - 20 November 2022. London, United Kingdom: Elsevier. doi: 10.1016/j.ijid.2023.04.053
Kumar, A., Tiwari, R., Singh, V., Chauhan, S., Singh, S., Engwerda, C., Sundar, S. and Kumar, R. (2023). A molecular and immunological signature of CD4 +T cells in post kala-azar dermal leishmaniasis. International Congress on Infectious Diseases 2022, Kuala Lumpur, Malaysia, 17 - 20 November 2022. London, United Kingdom: Elsevier. doi: 10.1016/j.ijid.2023.04.383
Edwards, C., Rivera, de Labastida F., de Oca, Montes M., Ng, S. and Engwerda, C. (2016). Characterisation of CD4(+) T cell responses during malaria. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Hoboken, NJ, United States: Wiley-Blackwell.
Cheong, Melody, Gartlan, Kate, Tey, Siok-Keen, Kuns, Rachel, Lor, Mary, Lineburg, Katie, Tea, Bianca, Shi, Wei, Raju, Jyothy, Zhang, Ping, Varelias, Antiopi, Leveque-El Mouttie, Lucie, Olver, Stuart, Bunting, Mark, Lane, Steven, Boyle, Glen, Ting, Jenny, Schroder, Kate, Engwerda, Christian, Khanna, Kum Kum, Smyth, Mark, MacDonald, Kelli, Koyama, Motoko and Hill, Geoffrey (2015). The adaptor protein ASC controls transplantation outcomes independently of the inflammasome. Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY), New Orleans La, May 08-12, 2015. BETHESDA: AMER ASSOC IMMUNOLOGISTS.
Alexander, K., Flynn, R., Lineburg, K., Kuns, R., Janela, B., Teal, B., Olver, S., Lor, M., Raffelt, N., Koyama, M., Leveque, L., Le Texier, L., Melino, M., Markey, K., Varelias, A., Ginhoux, F., Engwerda, C., Clouston, A., Blazer, B., Hill, G. and MacDonald, K. (2014). CSF-1-dependant M2 macrophages mediate chronic graft-versus-host disease. World Transplant Congress, San Francisco, CA, United States, 26-31 July 2014. Hoboken, NJ, United States: Wiley-Blackwell.
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