Associate Professor Josephine Bowles

Burnet, Guillaume, Bowles, Josephine and Spiller, Cassy M. (2023). Isolation and culture techniques for fetal mouse germ cells. Germline stem cells: methods and protocols. (pp. 221-231) edited by Michael Buszczak. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-3259-8_13

Spiller, Cassy and Bowles, Josephine (2019). Sexually dimorphic germ cell identity in mammals. Sex determination in vertebrates. (pp. 253-288) Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.ctdb.2019.01.011

Spiller, Cassy M., Burnet, Guillaume and Bowles, Josephine (2017). Mouse fetal germ cell isolation and culture techniques. Germline stem cells. (pp. 173-183) edited by Michael Buszczak. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-4017-2_13

Bowles, Josephine and Koopman, Peter (2015). Retinoic acid and the control of meiotic initiation. The retinoids: biology, biochemistry, and disease. (pp. 383-399) edited by Pascal Dolle and Karen Niederreither. New Jersey, NY, United States: Wiley - Blackwell. doi: 10.1002/9781118628003.ch17

Hargrave, M. R., Bowles, J. and Koopman, P. A. (2006). In situ hybridization of whole-mount embryos. In Situ Hybridization Protocols. (pp. 103-114) edited by Darby, I. and Hewitson, T.. Totowa, NJ United States: Humana Press.

Bowles, J. and Koopman, P. A. (2004). Gonads-Mullerian Ducts. Handbook of Stem Cells Volume 1. (pp. 345-357) edited by Lanza, R.P.; Gearhart, B.L.M.; Melton, D.A.;Pederson, R.; Thomson, M.D.; West and M.D.. USA: Elsevier Academic Oress. doi: 10.1016/B978-012436643-5/50042-0

Draskau, Monica K., Strand, Ida W., Davila, Raul, Ballegaard, Anne-Sofie R., Pedersen, Mikael, Ramhøj, Louise, Rising, Sofie, Tran, Kieu-mi, Axelstad, Marta, Bowles, Josephine, Rosenmai, Anna K., Spiller, Cassy M. and Svingen, Terje (2024). Perinatal exposure to environmental chemicals that disrupt thyroid function can perturb testis development. Environmental Pollution, 363 125117, 125117. doi: 10.1016/j.envpol.2024.125117

Burnet, Guillaume, Feng, Chun‐Wei Allen, Cheung, Ka Man Fiona, Bowles, Josephine and Spiller, Cassy M. (2023). Generation and characterization of a Ddx4‐iCre transgenic line for deletion in the germline beginning at genital ridge colonization. genesis, 61 (1-2) e23511, e23511. doi: 10.1002/dvg.23511

Spiller, Cassy and Bowles, Josephine (2022). Instructing mouse germ cells to adopt a female fate. Sexual Development, 16 (5-6), 1-13. doi: 10.1159/000523763

Davila, Raul Ayala, Spiller, Cassy, Harkins, Danyon, Harvey, Tracey, Jordan, Philip W., Gronostajski, Richard M., Piper, Michael and Bowles, Josephine (2022). Deletion of NFIX results in defective progression through meiosis within the mouse testis. Biology of Reproduction, 106 (6), 1191-1205. doi: 10.1093/biolre/ioac049

Nakagawa, Ryuichi, Takasawa, Kei, Gau, Maki, Tsuji-Hosokawa, Atsumi, Kawaji, Hideya, Murakawa, Yasuhiro, Takada, Shuji, Mikami, Masashi, Narumi, Satoshi, Fukami, Maki, Sreenivasan, Rajini, Maruyama, Tetsuo, Tucker, Elena J., Zhao, Liang, Bowles, Josephine, Sinclair, Andrew, Koopman, Peter, Hayashizaki, Yoshihide, Morio, Tomohiro and Kashimada, Kenichi (2022). Two ovarian candidate enhancers, identified by time series enhancer RNA analyses, harbor rare genetic variations identified in ovarian insufficiency. Human Molecular Genetics, 31 (13), 2223-2235. doi: 10.1093/hmg/ddac023

Kam Draskau, Monica, Ravn Ballegaard, Anne-Sofie, Ramhøj, Louise, Bowles, Josephine, Svingen, Terje and Spiller, Cassy M. (2022). AOP Key Event Relationship report: Linking decreased retinoic acid levels with disrupted meiosis in developing oocytes. Current Research in Toxicology, 3 100069, 1-8. doi: 10.1016/j.crtox.2022.100069

Ho, Uda Y., Feng, Chun-Wei Allen, Yeap, Yvonne Y., Bain, Amanda L., Wei, Zhe, Shohayeb, Belal, Reichelt, Melissa E., Homer, Hayden, Khanna, Kum Kum, Bowles, Josephine and Ng, Dominic C. H. (2021). WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Communications Biology, 4 (1) 645, 1-14. doi: 10.1038/s42003-021-02171-5

Feng, Chun-Wei, Burnet, Guillaume, Spiller, Cassy M., Cheung, Fiona Ka Man, Chawengsaksophak, Kallayanee, Koopman, Peter and Bowles, Josephine (2021). Identification of regulatory elements required for Stra8 expression, in fetal ovarian germ cells of the mouse. Development, 148 (5) dev194977, 1-13. doi: 10.1242/dev.194977

Spiller, Cassy M., Lobo, João, Boellaard, Willem P. A., Gillis, Ad J. M., Bowles, Josephine and Looijenga, Leendert H. J. (2020). CRIPTO and miR-371a-3p are serum biomarkers of testicular germ cell tumors and are detected in seminal plasma from azoospermic males. Cancers, 12 (3) 760, 760. doi: 10.3390/cancers12030760

Draskau, Monica Kam, Spiller, Cassy M., Boberg, Julie, Bowles, Josephine and Svingen, Terje (2020). Developmental biology meets toxicology: contributing reproductive mechanisms to build adverse outcome pathways. Molecular Human Reproduction, 26 (2), 111-116. doi: 10.1093/molehr/gaaa001

Davila, Raul Ayala, Harkins, Danyon, Currey, Laura, Fraser, James, Bowles, Josephine and Piper, Michael (2019). A simple, web-based repository for the management, access and analysis of micrographic images. Journal of Molecular Histology, 50 (6), 573-580. doi: 10.1007/s10735-019-09850-y

Croft, Brittany, Ohnesorg, Thomas, Hewitt, Jacqueline, Bowles, Josephine, Quinn, Alexander, Tan, Jacqueline, Corbin, Vincent, Pelosi, Emanuele, van den Bergen, Jocelyn, Sreenivasan, Rajini, Knarston, Ingrid, Robevska, Gorjana, Vu, Dung Chi, Hutson, John, Harley, Vincent, Ayers, Katie, Koopman, Peter and Sinclair, Andrew (2019). Author Correction: Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9. Nature Communications, 10 (1) 3351, 3351. doi: 10.1038/s41467-019-11310-w

Nomura, Risa, Kashimada, Kenichi, Suzuki, Hitomi, Zhao, Liang, Tsuji-Hosokawa, Atsumi, Yagita, Hideo, Takagi, Masatoshi, Kanai, Yoshiakira, Bowles, Josephine, Koopman, Peter, Kanai-Azuma, Masami and Morio, Tomohiro (2019). Nr5a1 suppression during the murine fetal period optimizes ovarian development by fine-tuning Notch signaling. Journal of Cell Science, 132 (8) 223768, jcs223768. doi: 10.1242/jcs.223768

Anuar, Nur Diana, Kurscheid, Sebastian, Field, Matt, Zhang, Lei, Rebar, Edward, Gregory, Philip, Buchou, Thierry, Bowles, Josephine, Koopman, Peter, Tremethick, David J. and Soboleva, Tatiana A. (2019). Gene editing of the multi-copy H2A.B gene and its importance for fertility 06 Biological Sciences 0604 Genetics Jin-Soo Kim. Genome Biology, 20 (1) 23, 23. doi: 10.1186/s13059-019-1633-3

Croft, Brittany, Ohnesorg, Thomas, Hewitt, Jacky, Bowles, Josephine, Quinn, Alexander, Tan, Jacqueline, Corbin, Vincent, Pelosi, Emanuele, van den Bergen, Jocelyn, Sreenivasan, Rajini, Knarston, Ingrid, Robevska, Gorjana, Vu, Dung Chi, Hutson, John, Harley, Vincent, Ayers, Katie, Koopman, Peter and Sinclair, Andrew (2018). Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9. Nature Communications, 9 (1) 5319, 5319. doi: 10.1038/s41467-018-07784-9

Bowles, Josephine, Feng, Chun-Wei, Ineson, Jessica, Miles, Kim, Spiller, Cassy M., Harley, Vincent R., Sinclair, Andrew H. and Koopman, Peter (2018). Retinoic acid antagonizes testis development in mice. Cell Reports, 24 (5), 1330-1341. doi: 10.1016/j.celrep.2018.06.111

Walton, Sarah L., Singh, Reetu R., Little, Melissa H., Bowles, Josephine, Li, Joan and Moritz, Karen M. (2018). Prolonged prenatal hypoxia selectively disrupts collecting duct patterning and postnatal function in male mouse offspring. The Journal of Physiology, 596 (23), 5873-5889. doi: 10.1113/JP275918

Sinha, Debottam, Kalimutho, Murugan, Bowles, Josephine, Chan, Ai-Leen, Merriner, D. Jo, Bain, Amanda L., Simmons, Jacinta L., Freire, Raimundo, Lopez, J Alejandro, Hobbs, Robin M., O'Bryan, Moira K. and Khanna, Kum Kum (2018). Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling. The FASEB Journal, 32 (9), 4984-4999. doi: 10.1096/fj.201701096RR

Feng, Chun-Wei Allen, Spiller, Cassy, Merriner, Donna J., O'Bryan, Moira K., Bowles, Josephine and Koopman, Peter (2017). SOX30 is required for male fertility in mice. Scientific Reports, 7 (1) 17619, 1-12. doi: 10.1038/s41598-017-17854-5

Spiller, Cassy, Koopman, Peter and Bowles, Josephine (2017). Sex Determination in the Mammalian Germline. Annual Review of Genetics, 51 (1), 265-285. doi: 10.1146/annurev-genet-120215-035449

Spiller, Cassy, Burnet, Guillaume and Bowles, Josephine (2017). Regulation of fetal male germ cell development by members of the TGFβ superfamily. Stem cell research, 24, 174-180. doi: 10.1016/j.scr.2017.07.016

Spiller, Cassy M. and Bowles, Josephine (2017). Germ cell neoplasia in situ: the precursor cell for invasive germ cell tumors of the testis. International Journal of Biochemistry & Cell Biology, 86, 22-25. doi: 10.1016/j.bioce1.2017.03.004

Spiller, Cassy M., Wilhelm, Dagmar, Jans, David A., Bowles, Josephine and Koopman, Peter (2017). Mice lacking Hbp1 function are viable and fertile. PLoS One, 12 (1) e0170576, e0170576. doi: 10.1371/journal.pone.0170576

Spiller, Cassy M., Gillis, Ad J. M., Burnet, Guillaume, Stoop, Hans, Koopman, Peter, Bowles, Josephine and Looijenga, Leendert H. J. (2016). Cripto: expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. Molecular Oncology, 10 (4), 526-537. doi: 10.1016/j.molonc.2015.11.003

Holm, Jacob Bak, Mazaud-Guittot, Severine, Danneskiold-Samsoe, Niels Banhos, Chalmey, Clementine, Jensen, Benjamin, Norregard, Mette Marie, Hansen, Cecilie Hurup, Styrishave, Bjarne, Svingen, Terje, Vinggaard, Anne Marie, Koch, Holger Martin, Bowles, Josephine, Koopman, Peter, Jegou, Bernard, Kristiansen, Karsten and Kristensen, David Mobjerg (2016). Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility. Toxicological Sciences, 150 (1), 178-189. doi: 10.1093/toxsci/kfv332

Bowles, Josephine, Feng, Chun-Wei, Miles, Kim, Ineson, Jessica, Spiller, Cassy and Koopman, Peter (2016). ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries. Nature Communications, 7 (1) 10845, 10845.1-10845.8. doi: 10.1038/ncomms10845

McClelland, Kathryn S. and Bowles, Josephine (2016). Culturing murine embryonic organs: pros, cons, tips and tricks. Differentiation, 91 (4-5), 50-56. doi: 10.1016/j.diff.2016.01.008

Rios-Rojas, Clarissa, Spiller, Cassy, Bowles, Josephine and Koopman, Peter (2016). Germ cells influence cord formation and leydig cell gene expression during mouse testis development. Developmental Dynamics, 245 (4), 433-444. doi: 10.1002/dvdy.24371

McClelland, Kathryn S., Ng, Ee Ting and Bowles, Josephine (2015). Agarose/gelatin immobilisation of tissues or embryo segments for orientated paraffin embedding and sectioning. Differentiation, 91 (4-5), 68-71. doi: 10.1016/j.diff.2015.12.001

McClelland, Kathryn S., Bell, Katrina, Larney, Christian, Harley, Vincent R., Sinclair, Andrew H., Oshlack, Alicia, Koopman, Peter A. and Bowles, Josephine (2015). Purification and Transcriptomic analysis of mouse fetal leydig cells reveals candidate genes for specification of gonadal steroidogenic cells. Biology of Reproduction, 92 (6), 145-145. doi: 10.1095/biolreprod.115.128918

Spiller, Cassy M. and Bowles, Josephine (2015). Sex determination in mammalian germ cells. Asian Journal of Andrology, 17 (3), 427-432. doi: 10.4103/1008-682X.150037

Rios-Rojas, Clarissa, Bowles, Josephine and Koopman, Peter (2015). On the role of germ cells in mammalian gonad development: quiet passengers or back-seat drivers?. Reproduction, 149 (4), R181-R191. doi: 10.1530/REP-14-0663

McClelland, Kathryn S., Wainwright, Elanor N., Bowles, Josephine and Koopman, Peter (2015). Rapid screening of gene function by systemic delivery of morpholino oligonucleotides to live mouse embryos. PLoS One, 10 (1) e0114932, 1-18. doi: 10.1371/journal.pone.0114932

Zhao, Liang, Ng, Ee Ting, Davidson, Tara-Lynne, Longmuss, Enya, Urschitz, Johann, Elston, Marlee, Moisyadi, Stefan, Bowles, Josephine and Koopman, Peter (2014). Structure-function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determination. Proceedings of the National Academy of Sciences, 111 (32), 11768-11773. doi: 10.1073/pnas.1400666111

Quinn, Alexander, Kashimada, Kenichi, Davidson, Tara-Lynne, Ng, Ee Ting, Chawengsaksophak, Kallayanee, Bowles, Josephine and Koopman, Peter (2014). A site-specific, single-copy transgenesis strategy to identify 5′ regulatory sequences of the mouse testis- determining gene Sry. PLoS One, 9 (4) e94813, 1-10. doi: 10.1371/journal.pone.0094813

Bowles, Josephine, Secker, Genevieve, Nguyen, Christelle, Kazenwadel, Jan, Truong, Vy, Framptom, Emmanuelle, Curtis, Cameron, Skoczylas, Renae, Davidson, Tara-Lynn, Miura, Naoyuki, Hong, Young-Kwon, Koopman, Peter, Harvey, Natasha L. and François, Mathias (2014). Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Developmental Biology, 386 (1), 25-33. doi: 10.1016/j.ydbio.2013.12.008

Feng, Chun-Wei, Bowles, Josephine and Koopman, Peter (2013). Control of mammalian germ cell entry into meiosis. Molecular and Cellular Endocrinology, 382 (1), 488-497. doi: 10.1016/j.mce.2013.09.026

Spiller, Cassy M., Bowles, Josephine and Koopman, Peter (2013). Regulation of germ cell meiosis in the fetal ovary. International Journal of Developmental Biology, 56 (10-12), 779-787. doi: 10.1387/ijdb.120142pk

Spiller, Cassy M., Bowles, Josephine and Koopman, Peter (2013). Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors. International Journal of Developmental Biology, 57 (2-4), 211-219. doi: 10.1387/ijdb.130028pk

Spiller, Cassy M., Feng, Chun-Wei, Jackson, Andrew, Gillis, Ad J. M., Rolland, Antoine D., Looijenga, Leendert H. J., Koopman, Peter and Bowles, Josephine (2012). Endogenous nodal signaling regulates germ cell potency during mammalian testis development. Development, 139 (22), 4123-4132. doi: 10.1242/dev.083006

Bowles, Josephine and Koopman, Peter A. (2012). Precious cargo: regulation of sex-specific germ cell development in mice. Sexual Development, 7 (1-3), 46-60. doi: 10.1159/000342072

DiTacchio, Luciano, Bowles, Josephine, Shin, Sook, Lim, Dae-Sik, Koopman, Peter and Janknecht, Ralf (2012). Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. Journal of Biological Chemistry, 287 (28), 23657-23666. doi: 10.1074/jbc.M111.320101

Griswold, Michael D., Hogarth, Cathryn A., Bowles, Josephine and Koopman, Peter A. (2012). Initiating meiosis: The case for retinoic acid. Biology of Reproduction, 86 (2) 35, 35.1-35.7. doi: 10.1095/biolreprod.111.096610

McClelland, Kathryn, Bowles, Josephine and Koopman, Peter (2012). Male sex determination: Insights into molecular mechanisms. Asian Journal of Andrology, 14 (1), 164-171. doi: 10.1038/aja.2011.169

Kashimada, Kenichi, Svingen, Terje, Feng, Chun-Wei, Pelosi, Emanuele, Bagheri-Fam, Stefan, Harley, Vincent R., Schlessinger, David, Bowles, Josephine and Koopman, Peter (2011). Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. The FASEB Journal, 25 (10), 3561-3569. doi: 10.1096/fj.11-184333

Combes, A. N., Bowles, J., Feng, C. -W., Chiu, H. S., Khoo, P. L., Jackson, A., Little, M. H., Tam, P. P. L. and Koopman, P. (2011). Expression and functional analysis of Dkk1 during early gonadal development. Sexual Development, 5 (3), 124-130. doi: 10.1159/000327709

Bowles, Josephine, Feng, Chun-Wei, Spiller, Cassy, Davidson, Tara-Lynne, Jackson, Andrew and Koopman, Peter (2010). FGF9 suppresses meiosis and promotes male germ cell fate in mice. Developmental Cell, 19 (3), 440-449. doi: 10.1016/j.devcel.2010.08.010

Bowles, Josephine and Koopman, Peter (2010). Sex determination in mammalian germ cells: extrinsic versus intrinsic factors. Reproduction, 139 (6), 943-958. doi: 10.1530/REP-10-0075

Ross, D.G.F., Bowles, J., Hope, M., Lehnert, S. and Koopman, P. (2009). Profiles of gonadal gene expression in the developing bovine embryo. Sexual Development, 3 (5), 273-283. doi: 10.1159/000252791

Bowles, Josephine, Feng, Chun-Wei, Knight, Deon, Smith, Craig A., Roeszler, Kelly N., Bagheri-Fam, Stefan, Harley, Vincent R., Sinclair, Andrew H. and Koopman, Peter (2009). Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: Implications for retinoid balance in gonad development. Developmental Dynamics, 238 (8), 2073-2080. doi: 10.1002/dvdy.22024

Ross, Diana G.F., Bowles, Josephine, Koopman, Peter and Lehnert, Sigrid (2008). New insights into SRY regulation through identification of 5' conserved sequences. BMC Molecular Biology, 9 (1) 85, 85.1-85.15. doi: 10.1186/1471-2199-9-85

Smith, Craig, Roeszler, Kelly, Bowles, Josephine, Koopman, Peter and Sinclair, Andrew (2008). Onset of meiosis in the chicken embryo; evidence of a role for retinoic acid. BMC Developmental Biology, 8 (85) 85. doi: 10.1186/1471-213X-8-85

Knower, K. C., Sim, H., McClive, P. J., Bowles, J., Koopman, P., Sinclair, A. H. and Harley, V. R. (2007). Characterisation of urogenital ridge gene expression in the human embryonal carcinoma cell line NT2/D1. Sexual Development, 1 (2), 114-126. doi: 10.1159/000100033

Bowles, J. and Koopman, P. (2007). Retinoic acid, meiosis and germ cell fate in mammals. Development, 134 (19), 3401-3411. doi: 10.1242/dev.001107

Hargrave, Murray, Bowles, Josephine and Koopman, Peter (2006). In situ hybridization of whole-mount embryos. Methods in Molecular Biology, 326, 103-113. doi: 10.1385/1-59745-007-3:103

Bowles, Josephine, Knight, Deon, Smith, Christopher, Wilhelm, Dagmar, Richman, Joy, Mamiya, Satoru, Yashiro, Kenta, Chawengsaksophak, Kallayanee, Wilson, Megan J., Rossant, Janet, Hamada, Hiroshi and Koopman, Peter (2006). Retinoid signaling determines germ cell fate in mice. Science, 312 (5773), 596-600. doi: 10.1126/science.1125691

Wilson, M. J., Bowles, J. and Koopman, P. (2006). The matricellular protein SPARC is internalized in Sertoli, Leydig, and germ cells during testis differentiation. Molecular Reproduction And Development, 73 (5), 531-539. doi: 10.1002/mrd.20394

Simpson, Fiona, Lammerts van Bueren, Kelly L., Butterfield, Natalie, Bennetts, Jennifer S., Bowles, Josephine, Adolphe, Christelle, Simms, Lisa A., Young, Joanne, Walsh, Michael D., Leggett, Barbara, Fowles, Lindsay F. and Wicking, Carol (2006). The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. Experimental Cell Research, 312 (1), 73-85. doi: 10.1016/j.yexcr.2005.09.020

Wilhelm, Dagmar, Martinson, Fred, Bradford, Stephen, Wilson, Megan J., Combes, Alexander N., Beverdam, Annemiek, Bowles, Josephine, Mizusaki, Hirofumi and Koopman, Peter (2005). Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Developmental Biology, 287 (1), 111-124. doi: 10.1016/j.ydbio.2005.08.039

Loffler, Kelly A., Combes, Alexander N., Wilhelm, Dagmar, Beverdam, Annemiek, Bowles, Jo and Koopman, Peter (2005). Pisrt1, a gene implicated in XX sex reversal, is expressed in gonads of both sexes during mouse development. Molecular Genetics and Metabolism, 86 (1-2), 286-292. doi: 10.1016/j.ymgme.2005.06.013

Jeanes, A., Wilhelm, D., Wilson, M. J., Bowles, J., McClive, P. J., Sinclair, A. H. and Koopman, P. (2005). Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis. Reproduction, 130 (4), 509-516. doi: 10.1530/rep.1.00718

Smith, James M., Bowles, Josephine, Wilson, Megan and Koopman, Peter (2004). HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis. Developmental Dynamics, 230 (2), 366-370. doi: 10.1002/dvdy.20053

Smith, J. M., Bowles, J., Wilson, M., Teasdale, R. D. and Koopman, P. (2004). Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Gene Expression Patterns, 4 (6), 701-705. doi: 10.1016/j.modgep.2004.04.002

Ellis, Tammy, Smyth, Ian, Riley, Emily, Bowles, Josephine, Adolphe, Christelle, Rothnagel, Joseph A., Wicking, Carol and Wainwright, Brandon J. (2003). Overexpression of sonic hedgehog suppresses embryonic hair follicle morphogenesis. Developmental Biology, 263 (2), 203-215. doi: 10.1016/S0012-1606(03)00394-4

Bullejos, Monica, Bowles, Jo and Koopman, Peter (2002). Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression. Developmental Dynamics, 225 (1), 95-99. doi: 10.1002/dvdy.10128

Koopman, P., Bullejos, M., Loffler, K. and Bowles, J. (2002). Expression-based strategies for discovery of genes involved in testis and ovary development. Genetics And Biology of Sex Determination, 244, 240-252.

Bowles, Josephine and Koopman, Peter (2001). New clues to the puzzle of mammalian sex determination. Genome Biology, 2 (9), 1-4. doi: 10.1186/gb-2001-2-9-reviews1025

Bowles, Josephine and Koopman, Peter (2001). New clues to the puzzle of mammalian sex determination. Genome Biology, 2 (9) ARTN 1025.1. doi: 10.1186/gb-2001-2-9-reviews1025

Georgas, Kylie, Bowles, Josephine, Yamada, Toshiya, Koopman, Peter and Little, Melissa H. (2000). Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern. Developmental Dynamics, 219 (4), 582-587. doi: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1072>3.0.CO;2-I

Bowles, J., Schepers, G. and Koopman, P. (2000). Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Developmental Biology, 227 (2), 239-255. doi: 10.1006/dbio.2000.9883

Bowles, Josephine, Bullejos, Monica and Koopman, Peter (2000). The maize CR4 receptor-like kinase mediates a growth factor-like differentiation response. Genesis, 27 (3), 104-116. doi: 10.1002/1526-968X(200007)27:3<104::AID-GENE30>3.0.CO;2-I

Bowles, Josephine, Bullejos, Monica and Koopman, Peter (2000). Screening for novel mammalian sex-determining genes using expression cloning and microarray approaches. Australian Biochemist, 31 (1), 4-6.

Pennisi, D., Bowles, J, Nagy, A., Muscat, G. and Koopman, P. (2000). Mice null for Sox18 are viable and display a mild coat defect. Molecular and Cell Biology, 20 (24), 9331-9336. doi: 10.1128/MCB.20.24.9331-9336.2000

Bowles, J., Bullejos, M. and Koopman, P. A. (2000). A substractive gene expression screen suggests a role for vanin-1 in testis development in mice. Genesis, 27 (3), 124-135. doi: 10.1002/1526-968X(200007)27:3<124::AID-GENE50>3.0.CO;2-E

Bowles, Josephine, Cooper, Leanne, Berkman, Jennifer and Koopman, Peter (1999). Sry requires a CAG repeat domain for male sex determination in Mus musculus. Nature Genetics, 22 (4), 405-408. doi: 10.1038/11981

Smyth, I, Bowles, J, Rothnagel, J, Wicking, C and Wainwright, B (1999). Ectopic expression of Sonic Hedgehog from the human Keratin 1 promoter gives rise to limb abnormalities and skin lesions in transgenic mice.. American Journal of Human Genetics, 65 (4), A371-A371.

Ng, Ling-Jim, Wheatley, Susan, Muscat, George E. O., Conway-Campbell, John, Bowles, Jo, Wright, Edwina, Bell, Donald M., Cheah, Kathryn S. E. and Koopman, Peter (1997). SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Developmental Biology, 183 (1), 108-121. doi: 10.1006/dbio.1996.8487

Shaw, J., Bowles, J., Koopman, P., Wood, E. C. and Trounson, A. O. (1996). Fresh and cryopreserved ovarian tissue samples from donors with lymphoma transmit the cancer to graft recipients. Human Reproduction, 11 (8), 1668-1673. doi: 10.1093/oxfordjournals.humrep.a019467

McManus, DP and Bowles, J (1996). Molecular genetic approaches to parasite identification: Their value in diagnostic parasitology and systematics. International Journal for Parasitology, 26 (7), 687-704. doi: 10.1016/0020-7519(96)82612-9

Jeske, Yvette W. A., Bowles, Josephine, Greenfield, Andy and Koopman, Peter (1995). Expression of a linear Sry transcript in the mouse genital ridge. Nature Genetics, 10 (4), 480-482. doi: 10.1038/ng0895-480

Bowles, J, Blair, D and McManus, DP (1995). A Molecular Phylogeny of the Human Schistosomes. Molecular Phylogenetics and Evolution, 4 (2), 103-109. doi: 10.1006/mpev.1995.1011

Bowles, J, Blair, D and McManus, DP (1995). A Molecular Phylogeny of the Genus Echinococcus. Parasitology, 110 (03), 317-328. doi: 10.1017/S0031182000080902

Bowles, J, Blair, D and McManus, DP (1994). Molecular-Genetic Characterization of the Cervid Strain (Northern Form) of Echinococcus-Granulosus. Parasitology, 109 (02), 215-221. doi: 10.1017/S0031182000076332

McManus, DP and Bowles, J (1994). Asian (Taiwan) Taenia - Species or Strain. Parasitology Today, 10 (7), 273-275. doi: 10.1016/0169-4758(94)90145-7

McManus, DP, Ding, ZX and Bowles, J (1994). A Molecular-Genetic Survey Indicates the Presence of a Single, Homogeneous Strain of Echinococcus-Granulosus in North-Western China. Acta Tropica, 56 (1), 7-14. doi: 10.1016/0001-706X(94)90035-3

Bowles, J and McManus, DP (1994). Genetic-Characterization of the Asian Taenia, a Newly Described Taeniid Cestode of Humans. American Journal of Tropical Medicine and Hygiene, 50 (1), 33-44. doi: 10.4269/ajtmh.1994.50.1.TM0500010033

Bowles, J, Hope, M, Tiu, WU, Liu, XS and McManus, DP (1993). Nuclear and Mitochondrial Genetic-Markers Highly Conserved Between Chinese and Philippine Schistosoma-Japonicum. Acta Tropica, 55 (4), 217-229. doi: 10.1016/0001-706X(93)90079-Q

Bowles, J and McManus, DP (1993). Nadh Dehydrogenase-1 Gene-Sequences Compared for Species and Strains of the Genus Echinococcus. International Journal for Parasitology, 23 (7), 969-972. doi: 10.1016/0020-7519(93)90065-7

Bowles, J and McManus, DP (1993). Molecular Variation in Echinococcus. Acta Tropica, 53 (3-4), 291-305. doi: 10.1016/0001-706X(93)90035-A

Wachira, TM, Bowles, J, Zeyhle, E and McManus, DP (1993). Molecular Examination of the Sympatry and Distribution of Sheep and Camel Strains of Echinococcus-Granulosus in Kenya. American Journal of Tropical Medicine and Hygiene, 48 (4), 473-479. doi: 10.4269/ajtmh.1993.48.473

Bowles, J and McManus, DP (1993). Rapid Discrimination of Echinococcus Species and Strains Using a Polymerase Chain Reaction-Based Rflp Method. Molecular and Biochemical Parasitology, 57 (2), 231-240. doi: 10.1016/0166-6851(93)90199-8

Bowles, J, Blair, D and McManus, DP (1992). Genetic-Variants Within the Genus Echinococcus Identified by Mitochondrial-Dna Sequencing. Molecular and Biochemical Parasitology, 54 (2), 165-174. doi: 10.1016/0166-6851(92)90109-W

Bowles, J, Vanknapen, F and McManus, D (1992). Cattle Strain of Echinococcus-Granulosus and Human Infection. Lancet, 339 (8805), 1358-1358. doi: 10.1016/0140-6736(92)92003-X

Hope, M, Bowles, J, Prociv, P and McManus, DP (1992). A Genetic Comparison of Human and Wildlife Isolates of Echinococcus-Granulosus in Queensland - Public-Health Implications. Medical Journal of Australia, 156 (1), 27-30.

McManus, D. P., Bowles, J., Leggatt, G. and Garcia-Zepeda, E. (1991). Some recent advances in the molecular characterization of Echinococcus and Taenia solium. The Southeast Asian journal of tropical medicine and public health, 22 Suppl, 256-261.

Hope, M, Bowles, J and McManus, DP (1991). A Reconsideration of the Echinococcus-Granulosus Strain Situation in Australia Following Rflp Analysis of Cystic Material. International Journal for Parasitology, 21 (4), 471-475. doi: 10.1016/0020-7519(91)90106-H

Scott, Hamish S., Matotek, Ebony, Mattiske, Tessa, Bryson-Richardson, Robert J., Smyth, Ian, Gecz, Jozef, Christodoulou, John, Palpant, Nathan, Smith, Kelly, Warr, Coral, Bennetts, Bruce, Thomas, Paul, Bowles, Josephine, Hilliard, Massimo, Hime, Gary, Hool, Livia, Quinn, Leonie, Wolvetang, Ernst, Jamieson, Robyn, Baynam, Gareth, Dudding-Byth, Tracy, Tan, Tiong Yang, Milnes, Di, Wallis, Mathew, Palmer, Elizabeth, Patel, Chirag, Jones, Kristi, Tam, Patrick, Stark, Zornitza ... Sinclair, Andrew (2024). How the Australian Functional Genomics Network (AFGN) contributes to improved patient care. Pathology Update 2024, Adelaide, SA, Australia, 1-3 March 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2023.12.084

Ayers, Katie, Eggers, Stefanie, Rollo, Ben, Smith, Katherine, Davidson, Nadia, Siddall, Nicole, Zhao, Liang, Bowles, Josephine, Weiss, Karin, Zanni, Ginevra, Burglen, Lydie, Ben Shachar, Shay, Rosensaft, Jenny, Raas-Rothschild, Annick, Jorgensen, Anne, Schittenhelm, Ralf, Huang, Cheng, Robevska, Gorjana, van den Bergen, Jocelyn, Casagranda, Franca, Cyza, Justyna, Pachernegg, Svenja, Wright, David, Bahlo, Melanie, Oshlack, Alicia, O'Brien, Terence, Kwan, Patrick, Koopman, Peter, Hime, Gary ... Sinclair, Andrew (2024). Variants in SART3 cause a novel spliceosomopathy characterised by failure of testis development and neuronal defects. 56th Annual Conference of the European Society of Human Genetics (ESHG), Glasgow, Scotland, 10-13 June 2023. London, United Kingdom: Nature Publishing Group.

Anuar, Nur Diana, Field, Matt, Kurscheid, Sebastian, Zhang, Lei, Rebar, Edward, Gregory, Philip, Bowles, Josephine, Koopman, Peter, Tremethick, David J. and Soboleva, Tatiana (2018). Gene editing of the multi-copy H2A.B gene family by a single pair of TALENs in mice. LONDON: BIOMED CENTRAL LTD.

Bowles, Josephine, Feng, Chun-Wei, Davidson, Tara and Koopman, Peter (2009). Sex fate determination in the germ line. 42nd Annual Meeting of the Society for the Study of Reproduction, Pittsburgh PA, 8-22 July 2009. United States: Society for the Study of Reproduction.

Farkas, D., Bowles, J., Lehnert, S.A. and Koopman, P.A. (2006). The production of male of-only offspring in beef cattle - a proof of principle project. 7th Transgenic Technology Meeting (TT2007), Brisbane, Qld, Australia, 12-14 February, 2007. Dordrecht,The Netherlands: Springer. doi: 10.1007/s11248-006-9047-x

Koopman, P., Knight, D., Smith, C., Wilson, M., Wilhelm, D., Richman, J., Rossant, J. and Bowles, J. (2005). Entry of germ cells into meiosis is induced by retinoic acid in mice.

Bowles, J., Knight, D., Smith, C., Wilson, M., Wilhelm, D., Richman, J., Rossant, J. and Koopman, P. (2005). Entry of mouse embryonic germ cells into meiosis is induced by retinoic acid.

Simpson, F., van Bueren, Lammerts K., Fowles, L., Berkman, J., Butterfield, N., Bowles, J., Adolphe, C., Simms, L., Young, J., Walsh, M. and Wicking, C. (2005). The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumour suppressor product p33ING1. Unknown, Unknown, Unknown. Amsterdam, Netherlands: Elsevier Science.

Bowles, J., Teasdale, R. D., James, K. M. and Koopman, P. A. (2003). Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. Vertebrate Sex Determination, Kona, Hawaii, 24-28 March, 2003. Basil, Switzerland: Karger. doi: 10.1159/000074346

Koopman, P.A., Bullejos Martin, M., Loffler, K.A. and Bowles, J. (2002). Expression-based strategies for discovery of genes involved in testis and ovary development. The genetics and biology of sex determination, Novartis Foundation, London, 1-3 May, 2001. Chichester, West Sussex, England ; New York, NY: Wiley & Sons.

Loffler, KA, Bowles, J and Koopman, P (2001). Assessment of candidate ovarian-determining genes.. SAN DIEGO: ACADEMIC PRESS INC.

Koopman, P., Bullejos, M. and Bowles, J. (2001). Regulation of male sexual development by Sry and Sox9. New York: John Wiley & Sons, Inc.. doi: 10.1002/jez.1089

Bullejos Martin, M., Bowles, J. and Koopman, P. A. (2001). Searching for missing pieces of the sex-determination puzzle. USA: Wiley-Liss Inc.. doi: 10.1002/jez.1095

Bowles, J., Cooper, L., Berkman, J. and Koopman, P. (1999). Mouse SRY requires a CAG repeat domain for male sex determination. -, -, 1999. Chicago, IL United States: University of Chicago Press.

Wheatley, Susan, Wright, Edwina, Jeske, Yvette, Mccormack, Andrew, Bowles, Josephine and Koopman, Peter (1996). Aetiology of the skeletal dysmorphology syndrome campomelic dysplasia: Expression of the Sox9 gene during chondrogenesis in mouse embryos. Conference on Molecular and Developmental Biology of Cartilage, Bethesda, MD, United States, 27-30 September 1995. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/j.1749-6632.1996.tb56306.x

Associate Professor Josephine Bowles

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