Dr Katharine Trenholme

Woolley, Stephen D., Fernandez, Melissa, Rebelo, Maria, Llewellyn, Stacey A., Marquart, Louise, Amante, Fiona H., Jennings, Helen E., Webster, Rebecca, Trenholme, Katharine, Chalon, Stephan, Moehrle, Joerg J., McCarthy, James S. and Barber, Bridget E. (2021). Development and evaluation of a new Plasmodium falciparum 3D7 blood stage malaria cell bank for use in malaria volunteer infection studies. Malaria Journal, 20 (1) 93, 93. doi: 10.1186/s12936-021-03627-z

Spicer, Timothy P., Gardiner, Donald L., Schoenen, Frank J., Roy, Sudeshna, Griffin, Patrick R., Chase, Peter, Scampavia, Louis, Hodder, Peter and Trenholme, Katharine R. (2018). Identification of antimalarial inhibitors using late-stage gametocytes in a phenotypic live/dead assay. SLAS Discovery. doi: 10.1177/2472555218796410

Pawliw, Rebecca, Farrow, Rebecca, Sekuloski, Silvana, Jennings, Helen, Healer, Julie, Thuan Phuong,, Sathe, Pri, Pasay, Cielo, Evans, Krystal, Cowman, Alan F., Schofield, Louis, Chen, Nanhua, McCarthy, James and Trenholme, Katharine (2018). A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial. Malaria Journal, 17 (1) 283, 283. doi: 10.1186/s12936-018-2435-x

da Silva, Fabio L., Dixon, Matthew W. A., Stack, Colin M., Teuscher, Franka, Taran, Elena, Jones, Malcolm K., Lovas, Erica, Tilley, Leann, Brown, Christopher L., Trenholme, Katharine R., Dalton, John P., Gardiner, Donald L. and Skinner-Adams, Tina S. (2016). A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability. Experimental Parasitology, 169, 13-21. doi: 10.1016/j.exppara.2016.06.013

Stanisic, Danielle I., Gerrard, John, Fink, James, Griffin, Paul M., Liu, Xue Q., Sundac, Lana, Sekuloski, Silvana, Rodriguez, Ingrid B., Pingnet, Jolien, Yang, Yuedong, Zhou, Yaoqi, Trenholme, Katharine R., Wang, Claire Y. T., Hackett, Hazel, Chan, Jo-Anne A., Langer, Christine, Hanssen, Eric, Hoffman, Stephen L., Beeson, James G., McCarthy, James S. and Good, Michael F. (2016). Infectivity of Plasmodium falciparum in malaria-naive individuals is related to knob expression and cytoadherence of the parasite. Infection and Immunity, 84 (9), 2689-2696. doi: 10.1128/IAI.00414-16

McCarthy, James S., Marquart, Louise, Sekuloski, Silvana, Trenholme, Katherine, Elliott, Suzanne, Griffin, Paul, Rockett, Rebecca, O'Rourke, Peter, Sloots, Theo, Angulo-Barturen, Inigo, Ferrer, Santiago, Jimenez-Diaz, Maria Belen, Martinez, Maria-Santos, van Huijsduijnen, Rob Hoof, Duparc, Stephan, Leroy, Didier, Wells, Timothy N. C., Baker, Mark and Mohrle, Jorg J. (2016). Linking murine and human Plasmodium falciparum challenge models in a translational path for antimalarial drug development. Antimicrobial Agents and Chemotherapy, 60 (6), 3669-3675. doi: 10.1128/AAC.02883-15

Stanisic, Danielle I., Liu, Xue Q., De, Sai Lata, Batzloff, Michael R., Forbes, Tanya, Davis, Christopher B., Sekuloski, Silvana, Chavchich, Marina, Chung, Wendy, Trenholme, Katharine, McCarthy, James S., Li, Tao, Sim, B. Kim Lee, Hoffman, Stephen L. and Good, Michael F. (2015). Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines. Malaria Journal, 14 (1) 143, 1-10. doi: 10.1186/s12936-015-0663-x

Gardiner, Donald L. and Trenholme, Katharine R. (2015). Plasmodium falciparum gametocytes: Playing hide and seek. Annals of Translational Medicine, 3 (4) 45, 1-3. doi: 10.3978/j.issn.2305-5839.2015.01.23

Trenholme, Katharine, Marek, Linda, Duffy, Sandra, Pradel, Gabriele, Fisher, Gillian, Hansen, Finn K., Skinner-Adams, Tina S., Butterworth, Alice, Ngwa, Che Julius, Moecking, Jonas, Goodman, Christopher D., McFadden, Geoffrey I., Sumanadasa, Subathdrage D. M., Fairlie, David P., Avery, Vicky M., Kurz, Thomas and Andrews, Katherine T. (2014). Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules. Antimicrobial Agents and Chemotherapy, 58 (7), 3666-3678. doi: 10.1128/AAC.02721-13

Vu, Hoan, Roullier, Catherine, Campitelli, Marc, Trenholme, Katharine R., Gardiner, Donald L., Andrews, Katherine T., Skinner-Adams, Tina, Crowther, Gregory J., Van Voorhis, Wesley C. and Quinn, Ronald J. (2013). Plasmodium gametocyte inhibition identified from a natural-product-based fragment library. ACS Chemical Biology, 8 (12), 2654-2659. doi: 10.1021/cb400582b

McCarthy, James S., Griffin, Paul M., Sekuloski, Silvana, Bright, A. Taylor, Rockett, Rebecca, Looke, David, Elliott, Suzanne, Whiley, David, Sloots, Theo, Winzeler, Elizabeth A. and Trenholme, Katharine R. (2013). Experimentally induced blood-stage plasmodium vivax infection in healthy volunteers. Journal of Infectious Diseases, 208 (10), 1688-1694. doi: 10.1093/infdis/jit394

Peatey, Christopher L., Watson, Jolanta A., Trenholme, Katharine R., Brown, Christopher L., Nielson, Lars, Guenther, Marko, Timmins, Nicholas, Watson, Gregory S. and Gardiner, Donald L. (2013). Enhanced gametocyte formation in erythrocyte progenitor cells: A site-specific adaptation by Plasmodium falciparum. The Journal of Infectious Diseases, 208 (7), 1170-1174. doi: 10.1093/infdis/jit309

Peatey, Christopher L., Dixon, Matthew W. A., Gardiner, Donald L. and Trenholme, Katharine R. (2013). Temporal evaluation of commitment to sexual development in Plasmodium falciparum. Malaria Journal, 12 (1) 134. doi: 10.1186/1475-2875-12-134

Butterworth, Alice S., Skinner-Adams, Tina S., Gardiner, Don L. and Trenholme, Katharine R. (2013). Plasmodium falciparum gametocytes: With a view to a kill. Parasitology, 140 (14), 1718-1734. doi: 10.1017/S0031182013001236

Sivaraman, Komagal Kannan, Oellig, Christine A., Huynh, Kitmun, Atkinson, Sarah C., Poreba, Marcin, Perugini, Matthew A., Trenholme, Katharine R., Gardiner, Donald L., Salvesen, Guy, Drag, Marcin, Dalton, John P., Whisstock, James C. and McGowan, Sheena (2012). X-ray crystal structure and specificity of the plasmodium falciparum malaria aminopeptidase PfM18AAP. Journal of Molecular Biology, 422 (4), 495-507. doi: 10.1016/j.jmb.2012.06.006

Thivierge, Karine, Mathew, Rency T., Nsangou, Desire M. M., Da Silva, Fabio, Cotton, Sophie, Skinner-Adams, Tina S., Trenholme, Katharine R., Brown, Christopher L., Stack, Colin M., Gardiner, Donald L. and Dalton, John P. (2012). Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases. Arkivoc, 2012 (4), 330-346. doi: 10.3998/ark.5550190.0013.424

Skinner-Adams, Tina S., Peatey, Christopher L., Anderson, Karen, Trenholme, Katharine R., Krige, David, Brown, Christopher L., Stack, Colin, Nsangou, Desire M. M., Mathews, Rency T., Thivierge, Karine, Dalton, John P. and Gardiner, Donald L. (2012). The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria. Antimicrobial Agents and Chemotherapy, 56 (6), 3244-3249. doi: 10.1128/AAC.06245-11

Peatey, Christopher L., Leroy, Didier, Gardiner, Donald L. and Trenholme, Katharine R. (2012). Anti-malarial drugs: How effective are they against Plasmodium falciparum gametocytes?. Malaria Journal, 11 (34) 34, 34.1-34.4. doi: 10.1186/1475-2875-11-34

Poreba, Marcin, McGowan, Sheena, Skinner-Adams, Tina S., Trenholme, Katharine R., Gardiner, Donald L., Whisstock, James C., To, Joyce, Salvesen, Guy S., Dalton, John P. and Drag, Marcin (2012). Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. Plos One, 7 (2) e31938, 1-8. doi: 10.1371/journal.pone.0031938

Peatey, Christopher L., Spicer, Timothy P., Hodder, Peter S., Trenholme, Katharine R. and Gardiner, Donald L. (2011). A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes. Molecular and Biochemical Parasitology, 180 (2), 127-131. doi: 10.1016/j.molbiopara.2011.09.002

McCarthy, James S., Sekuloski, Silvana, Griffin, Paul M., Elliott, Suzanne, Douglas, Nanette, Peatey, Chris, Rockett, Rebecca, O'Rourke, Peter, Marquart, Louise, Hermsen, Cornelius, Duparc, Stephan, Moehrle, Joerg, Trenholme, Katharine R. and Humberstone, Andrew J. (2011). A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs. PLoS ONE, 6 (8) e21914, e21914-1-e21914-8. doi: 10.1371/journal.pone.0021914

Butterworth, Alice S., Robertson, Alan J., Ho, Mei-Fong, Gatton, Michelle L., McCarthy, James S. and Trenholme, Katharine R. (2011). An improved method for undertaking limiting dilution assays for in vitro cloning of Plasmodium falciparum parasites. Malaria Journal, 10 (1) 95, 1-5. doi: 10.1186/1475-2875-10-95

Rockett, Rebecca J., Tozer, Sarah J., Peatey, Chris, Bialasiewicz, Seweryn, Whiley, David M., Nissen, Michael D., Trenholme, Katharine, Mc Carthy, James S. and Sloots, Theo P. (2011). A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers. Malaria Journal, 10 (48) 48, 48-1-48-6. doi: 10.1186/1475-2875-10-48

Peatey, Christopher L., Andrews, Katherine T., Eickel, Nina, MacDonald, Timothy, Butterworth, Alice S., Trenholme, Katharine R., Gardiner, Donald L., McCarthy, James S. and Skinner-Adams, Tina S. (2010). Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors. Antimicrobial Agents and Chemotherapy, 54 (3), 1334-1337. doi: 10.1128/AAC.01512-09

Trenholme, Katharine R., Brown, Christopher L., Skinner-Adams, Tina S., Stack, Colin, Lowther, Jonathan, To, Joyce, Robinson, Mark W., Donnelly, Sheila M., Dalton, John P. and Gardiner, Donald L. (2010). Aminopeptidases of malaria parasites: new targets for chemotherapy. Infectious Disorders - Drug Targets, 10 (3), 217-225. doi: 10.2174/187152610791163363

Gardiner, Donald L., Skinner-Adams, Tina S., Brown, Christopher L., Andrews, Katherine T., Stack, Colin M., McCarthy, James S., Dalton, John P. and Trenholme, Katharine R. (2009). Plasmodium falciparum: New molecular targets with potential for antimalarial drug development. Expert Review of Anti-Infective Therapy, 7 (9), 1087-1098. doi: 10.1586/ERI.09.93

Peatey, Christopher L., Skinner-Adams, Tina S., Dixon, Matthew W. A., McCarthy, James S., Gardiner, Donald L. and Trenholme, Katharine R. (2009). Effect of Antimalarial Drugs on Plasmodium falciparum Gametocytes. The Journal of Infectious Diseases, 200 (10), 1518-1521. doi: 10.1086/644645

McGowan, Sheena, Porter, Corrine J., Lowther, Jonathan, Stack, Colin M., Golding, Sarah J., Skinner-Adams, Tina S., Trenholme, Katharine R., Teuscher, Franka, Donnelly, Sheila M., Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, DeGori, Ross, Buckle, Ashley M., Gardiner, Donald L., Whisstock, James C. and Dalton, John P. (2009). Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proceedings of the National Academy of Sciences of USA, 106 (8), 2537-2542. doi: 10.1073/pnas.0807398106

Chung, Wendy Y., Gardiner, Donald L., Hyland, Catharine and Trenholme, Katharine R. (2008). Invasion of Rh null cells by Plasmodium falciparum identifies a new invasion pathway. Parasitology Research, 102 (2), 259-263. doi: 10.1007/s00436-007-0756-8

Hanssen, Eric, Hawthorne, Paula, Dixon, Matthew W. A., Trenholme, Katharine R, McMillan, Paul J., Spielmann, Tobias, Gardiner, Donald L. and Tilley, Leann (2008). Targeted mutagenesis of the ring-exported protein-1 of Plasmodium falciparum disrupts the architecture of Maurer's cleft organelles. Molecular Microbiology, 69 (4), 938-953. doi: 10.1111/j.1365-2958.2008.06329.x

Dixon, Matthew W. A., Hawthorne, Paula L., Spielmann, Tobias, Anderson, Karen L., Trenholme, Katharine R. and Gardiner, Donald L. (2008). Targeting of the ring exported protein 1 to the Maurer's Clefts is mediated by a two-phase process. Traffic, 9 (8), 1316-1326. doi: 10.1111/j.1600-0854.2008.00768.x

Skinner-Adams, Tina S., Lowther, Jonathan, Teuscher, Franka, Stack, Colin M., Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Trenholme, Katharine R., Dalton, John P. and Gardiner, Donald L. (2007). Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds. Journal of Medicinal Chemistry, 50 (24), 6024-6031. doi: 10.1021/jm070733v

Jackson, Katherine E., Spielmann, Tobias, Hanssen, Eric, Adisa, Akinola, Separovic, Frances, Dixon, Matthew W. A., Trenholme, Katharine R., Hawthorne, Paula L., Gardiner, Don L., Gilberger, Tim and Tilley, Leann (2007). Selective permeabilization of the host cell membrane of Plasmodium falciparum-infected red blood cells with streptolysin 0 and equinatoxin II. Biochemical Journal, 403 (1), 167-175. doi: 10.1042/BJ20061725

Stack, Colin M., Lowther, Jonathan, Cunningham, Eithne, Donnelly, Sheila, Gardiner, Donald L., Trenholme, Katharine R., Skinner-Adams, Tina S., Teuscher, Franka, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Lua, Linda, Bell, Angus and Dalton, John P. (2007). Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development. Journal of Biological Chemistry, 282 (3), 2069-2080. doi: 10.1074/jbc.M609251200

Spielmann, Tobias, Hawthorne, Paula L., Dixon, Matthew W. A., Hannemann, Mandy, Klotz, Kathleen, Kemp, David J., Klonis, Nectarios, Tilley, Leann, Trenholme, Katharine R. and Gardiner, Donald L. (2006). A cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell. Molecular Biology of the Cell, 17 (8), 3613-3624. doi: 10.1091/mbc.E06-04-0291

Spielmann, Tobias, Gardiner, Donald L., Beck, Hans-Peter, Trenholme, Katharine R. and Kemp, David J. (2006). Organization of ETRAMPs and EXP-1 at the parasite-host cell interface of malaria parasites. Molecular Microbiology, 59 (3), 779-794. doi: 10.1111/j.1365-2958.2005.04983.x

Gardiner, Donald L., Trenholme, Katharine R., Skinner-Adams, Tina S., Stack, Colin M. and Dalton, John P. (2006). Overexpression of Leucyl Aminopeptidase in Plasmodium falciparum Parasites. Target for the antimalarial activity of bestatin. Journal of Biological Chemistry, 281 (3), 1741-1745. doi: 10.1074/jbc.M508955200

Chung, Wendy Y., Gardiner, Donald L., Hyland, Catherine, Gatton, Michelle, Kemp, David J. and Trenholme, Katharine R. (2005). Enhanced invasion of blood group A1 erythrocytes by Plasmodium falciparum. Molecular and Biochemical Parasitology, 144 (1), 128-130. doi: 10.1016/j.molbiopara.2005.08.004

Gardiner, D. L., McCarthy, J. S. and Trenholme, K. R. (2005). Malaria in the post-genomics era: light at the end of the tunnel or just another train?. Postgraduate Medical Journal, 81 (958), 505-509. doi: 10.1136/pgmj.2004.030304

Trenholme, Katharine R., Boutlis, Craig S., Kuns, Rachel, Lagog, Moses, Bockarie, Moses J., Gatton, Michelle L., Kemp, David J., Good, Michael F., Anstey, Nicholas M. and Gardiner, Donald L. (2005). Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea. American Journal of Tropical Medicine and Hygiene, 72 (6), 708-713.

Gardiner, Donald L., Dixon, Matthew W. A., Spielmann, Tobias, Skinner-Adams, Tina S., Hawthorne, Paula L., Ortega, Maria R., Kemp, David J. and Trenholme, Katharine R. (2005). Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis. Molecular and Biochemical Parasitology, 140 (2), 153-160. doi: 10.1016/j.molbiopara.2004.12.010

Hawthorne, Paula L., Trenholme, Katharine R., Skinner-Adams, Tina S., Spielmann, Tobias, Fischer, Katja, Dixon, Matthew W. A., Ortega, Maria R., Anderson, Karen L., Kemp, David J. and Gardiner, Donald L. (2004). A novel Plasmodium falciparum ring stage protein, REX, is located in Maurer's clefts. Molecular and Biochemical Parasitology, 136 (2), 181-189. doi: 10.1016/j.molbiopara.2004.03.013

Gardiner, Donald L., Spielmann, Tobias, Dixon, Matthew W. A., Hawthorne, Paula L., Ortega, Maria R., Anderson, Karen L., Skinner-Adams, Tina S., Kemp, David J. and Trenholme, Katharine R. (2004). CLAG 9 is located in the rhoptries of Plasmodium falciparum. Parasitology Research, 93 (1), 64-67. doi: 10.1007/s00436-004-1098-4

Gardiner, Donald L., Skinner-Adams, Tina S., Spielmann, Tobias and Trenholme, Katharine R. (2003). Malaria transfection and transfection vectors. Trends In Parasitology, 19 (9), 381-383. doi: 10.1016/S1471-4922(03)00187-9

Skinner-Adams, Tina S, Lawrie, Paula M, Hawthorne, Paula L, Gardiner, Donald L and Trenholme, Katharine R (2003). Comparison of Plasmodium falciparum transfection methods. Malaria Journal, 2 1, 1-4. doi: 10.1186/1475-2875-2-1

Skinner-Adams, Tina S., Lawrie, Paula M., Hawthorne, Paula L., Gardiner, Donald L. and Trenholme, Katharine R. (2003). Comparison of Plasmodium falciparum transfection methods. Malaria Journal, 2 (1), 19.1-19.4. doi: 10.1186/1475-2875-2-19

Skinner-Adams, Tina S., Hawthorne, Paula L., Trenholme, Katharine R. and Gardiner, Donald L. (2003). GATEWAY™ vectors for Plasmodium falciparum transfection. Trends in Parasitology, 19 (1), 17-18. doi: 10.1016/S1471-4922(02)00005-3

Holt, Deborah C., Fischer, Katja, Tchavtchitch, Marina, Wilson, Danny W., Hauquitz, Nova E., Hawthorne, Paula L., Gardiner, Donald L., Trenholme, Katharine R. and Kemp, David J. (2001). Clags in Plasmodium falciparum and other species of Plasmodium. Molecular And Biochemical Parasitology, 118 (2), 259-263. doi: 10.1016/S0166-6851(01)00378-4

Trenholme, K. R., Teuscher, F., Skinner-Adams, T. S., Stack, C. M., Dalton, J. P. and Gardiner, D. L. (2008). The aspartyl aminopeptidase of Plasmodium falciparum. Molecular Approaches to Malaria (MAM) 2008, Lorne, VIC Australia, 3-7 February 2008. London, United Kingdom: Elsevier. doi: 10.1016/S0020-7519(07)00459-6

Dr Katharine Trenholme

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