Honorary Professor Ross Hannan

Cameron, Donald P., Sornkom, Jirawas, Alsahafi, Sameerh, Drygin, Denis, Poortinga, Gretchen, Mcarthur, Grant A., Hein, Nadine, Hannan, Ross and Panov, Konstantin I. (2024). CX-5461 preferentially induces Top2α-dependent DNA breaks at ribosomal DNA loci. Biomedicines, 12 (7) 1514, 1514. doi: 10.3390/biomedicines12071514

Horvath, Attila, Janapala, Yoshika, Woodward, Katrina, Mahmud, Shafi, Cleynen, Alice, Gardiner, Elizabeth E., Hannan, Ross D., Eyras, Eduardo, Preiss, Thomas and Shirokikh, Nikolay E. (2024). Comprehensive translational profiling and STE AI uncover rapid control of protein biosynthesis during cell stress. Nucleic Acids Research, 52 (13) gkae365, 7925-7946. doi: 10.1093/nar/gkae365

Kang, Chang-Won, Blackburn, Anneke C., Loh, Amos Hong Pheng, Hong, Kuick Chick, Goh, Jian Yuan, Hein, Nadine, Drygin, Denis, Parish, Chris R., Hannan, Ross D., Hannan, Katherine M. and Coupland, Lucy A. (2023). Targeting RNA Polymerase I transcription activity in osteosarcoma: pre-clinical molecular and animal treatment studies. Biomedicines, 11 (4) 1133. doi: 10.3390/biomedicines11041133

Hannan, Katherine M., Soo, Priscilla, Wong, Mei S., Lee, Justine K., Hein, Nadine, Poh, Perlita, Wysoke, Kira D., Williams, Tobias D., Montellese, Christian, Smith, Lorey K., Al-Obaidi, Sheren J., Núñez-Villacís, Lorena, Pavy, Megan, He, Jin-Shu, Parsons, Kate M., Loring, Karagh E., Morrison, Tess, Diesch, Jeannine, Burgio, Gaetan, Ferreira, Rita, Feng, Zhi-Ping, Gould, Cathryn M., Madhamshettiwar, Piyush B., Flygare, Johan, Gonda, Thomas J., Simpson, Kaylene J., Kutay, Ulrike, Pearson, Richard B., Engel, Christoph ... George, Amee J. (2022). Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway. Cell Reports, 41 (5) 111571, 1-24. doi: 10.1016/j.celrep.2022.111571

Kang, Chang-Won, Hannan, Katherine M., Blackburn, Anneke C., Loh, Amos H. P., Hong, Kuick Chik, Yuan, Goh Jian, Hein, Nadine, Drygin, Denis, Hannan, Ross D. and Coupland, Lucy A. (2022). The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma. Investigational New Drugs, 40 (3), 529-536. doi: 10.1007/s10637-022-01222-w

Lawrence, Mitchell G., Porter, Laura H., Choo, Nicholas, Pook, David, Grummet, Jeremy P., Pezaro, Carmel J., Sandhu, Shahneen, Ramm, Susanne, Luu, Jennii, Bakshi, Andrew, Goode, David L., Sanij, Elaine, Pearson, Richard B., Hannan, Ross D., Simpson, Kaylene J., Taylor, Renea A., Risbridger, Gail P. and Furic, Luc (2021). CX-5461 sensitizes DNA damage repair-proficient castrate-resistant prostate cancer to PARP inhibition. Molecular Cancer Therapeutics, 20 (11), 2140-2150. doi: 10.1158/1535-7163.MCT-20-0932

Panov, Konstantin I., Hannan, Katherine, Hannan, Ross D. and Hein, Nadine (2021). The ribosomal gene loci—the power behind the throne. Genes, 12 (5) 763, 1-17. doi: 10.3390/genes12050763

Amarasiri, Madushani, Vo, Yen, Gardiner, Michael G., Poh, Perlita, Soo, Priscilla, Pavy, Megan, Hein, Nadine, Ferreira, Rita, Hannan, Katherine M., Hannan, Ross D. and Banwell, Martin G. (2021). The synthesis and biological evaluation of some c-9 and c-10 substituted derivatives of the rna polymerase i transcription inhibitor CX-5461. Australian Journal of Chemistry, 74 (7), 540-556. doi: 10.1071/CH21049

Yan, Shunfei, Xuan, Jiachen, Brajanovski, Natalie, Tancock, Madeleine R. C., Madhamshettiwar, Piyush B., Simpson, Kaylene J., Ellis, Sarah, Kang, Jian, Cullinane, Carleen, Sheppard, Karen E., Hannan, Katherine M., Hannan, Ross D., Sanij, Elaine, Pearson, Richard B. and Chan, Keefe T. (2021). The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer. British Journal of Cancer, 124 (3), 616-627. doi: 10.1038/s41416-020-01158-z

Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E. and Pearson, Richard B. (2020). CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer. Nature Communications, 11 (1) 2641, 1-18. doi: 10.1038/s41467-020-16393-4

Chin, Chue Vin, Antony, Jisha, Ketharnathan, Sarada, Labudina, Anastasia, Gimenez, Gregory, Parsons, Kate M., He, Jinshu, George, Amee J., Pallotta, Maria Michela, Musio, Antonio, Braithwaite, Antony, Guilford, Parry, Hannan, Ross D. and Horsfield, Julia A. (2020). Cohesin mutations are synthetic lethal with stimulation of WNT signaling. eLife, 9 e61405, 1-21. doi: 10.7554/ELIFE.61405

Gao, Jixuan, Jung, MoonSun, Mayoh, Chelsea, Venkat, Pooja, Hannan, Katherine M., Fletcher, Jamie I., Kamili, Alvin, Gifford, Andrew J., Kusnadi, Eric P., Pearson, Richard B., Hannan, Ross D., Haber, Michelle, Norris, Murray D., Somers, Klaartje and Henderson, Michelle J. (2020). Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression. Cancer Research, 80 (17), 3706-3718. doi: 10.1158/0008-5472.CAN-19-3914

Son, Jinbae, Hannan, Katherine M., Poortinga, Gretchen, Hein, Nadine, Cameron, Donald P., Ganley, Austen R. D., Sheppard, Karen E., Pearson, Richard B., Hannan, Ross D. and Sanij, Elaine (2020). rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461. Frontiers in Cell and Developmental Biology, 8 568, 568. doi: 10.3389/fcell.2020.00568

Ferreira, Rita, Schneekloth, John S., Panov, Konstantin I., Hannan, Katherine M. and Hannan, Ross D. (2020). Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age. Cells, 9 (2) 266, 266. doi: 10.3390/cells9020266

Kusnadi, Eric P., Trigos, Anna S., Cullinane, Carleen, Goode, David L., Larsson, Ola, Devlin, Jennifer R., Chan, Keefe T., De Souza, David P., McConville, Malcolm J., McArthur, Grant A., Thomas, George, Sanij, Elaine, Poortinga, Gretchen, Hannan, Ross D., Hannan, Katherine M., Kang, Jian and Pearson, Richard B. (2020). Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis. EMBO Journal, 39 (21) e105111, 1-17. doi: 10.15252/embj.2020105111

Liu, Pei Y., Tee, Andrew E., Milazzo, Giorgio, Hannan, Katherine M., Maag, Jesper, Mondal, Sujanna, Atmadibrata, Bernard, Bartonicek, Nenad, Peng, Hui, Ho, Nicholas, Mayoh, Chelsea, Ciaccio, Roberto, Sun, Yuting, Henderson, Michelle J., Gao, Jixuan, Everaert, Celine, Hulme, Amy J., Wong, Matthew, Lan, Qing, Cheung, Belamy B., Shi, Leming, Wang, Jenny Y., Simon, Thorsten, Fischer, Matthias, Zhang, Xu D., Marshall, Glenn M., Norris, Murray D., Haber, Michelle, Vandesompele, Jo ... Liu, Tao (2019). The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35. Nature Communications, 10 (1) 5026, 5026. doi: 10.1038/s41467-019-12971-3

Shirokikh, Nikolay E., Dutikova, Yulia S., Staroverova, Maria A., Hannan, Ross D. and Preiss, Thomas (2019). Migration of Small Ribosomal Subunits on the 5' Untranslated Regions of Capped Messenger RNA. International Journal of Molecular Sciences, 20 (18) 4464, 4464. doi: 10.3390/ijms20184464

Khot, Amit, Brajanovski, Natalie, Cameron, Donald P., Hein, Nadine, Maclachlan, Kylee H., Sanij, Elaine, Lim, John, Soong, John, Link, Emma, Blombery, Piers, Thompson, Ella R., Fellowes, Andrew, Sheppard, Karen E., McArthur, Grant A., Pearson, Richard B., Hannan, Ross D., Poortinga, Gretchen and Harrison, Simon J. (2019). First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study. Cancer Discovery, 9 (8), 1036-1049. doi: 10.1158/2159-8290.CD-18-1455

Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D., George, Amee J., Sanij, Elaine, Hannan, Katherine M., Simpson, Kaylene J. and Pearson, Richard B. (2019). A functional genetic screen defines the AKT-induced senescence signaling network. Cell Death and Differentiation, 27 (2), 725-741. doi: 10.1038/s41418-019-0384-8

Diesch, Jeannine, Bywater, Megan J., Sanij, Elaine, Cameron, Donald P., Schierding, William, Brajanovski, Natalie, Son, Jinbae, Sornkom, Jirawas, Hein, Nadine, Evers, Maurits, Pearson, Richard B., McArthur, Grant A., Ganley, Austen R. D., O'Sullivan, Justin M., Hannan, Ross D. and Poortinga, Gretchen (2019). Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation. Communications Biology, 2 (1) 39, 39. doi: 10.1038/s42003-019-0284-y

Martin, Claire A., Cullinane, Carleen, Kirby, Laura, Abuhammad, Shatha, Lelliott, Emily J., Waldeck, Kelly, Young, Richard J., Brajanovski, Natalie, Cameron, Donald P., Walker, Rachael, Sanij, Elaine, Poortinga, Gretchen, Hannan, Ross D., Pearson, Richard B., Hicks, Rodney J., McArthur, Grant A. and Sheppard, Karen E. (2018). Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance. International Journal of Cancer, 142 (10), 2139-2152. doi: 10.1002/ijc.31220

Hein, Nadine, Hannan, Kathrine M., D'Rozario, James and Hannan, Ross (2017). Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer. Technology in Cancer Research and Treatment, 16 (6), 736-739. doi: 10.1177/1533034617744955

Venugopal, Parvathy, Moore, Sarah, Lawrence, David M., George, Amee J., Hannan, Ross D., Bray, Sarah C. E., To, Luen Bik, D'Andrea, Richard J., Feng, Jinghua, Tirimacco, Amanda, Yeoman, Alexandra L., Young, Chun Chun, Fine, Miriam, Schreiber, Andreas W., Hahn, Christopher N., Barnett, Christopher, Saxon, Ben and Scott, Hamish S. (2017). Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan anemia patient. Haematologica, 102 (12), 506-509. doi: 10.3324/haematol.2017.166678

Rebello, Richard J., Pearson, Richard B., Hannan, Ross D. and Furic, Luc (2017). Therapeutic approaches targeting MYC-Driven prostate cancer. Genes, 8 (2) 71, 71. doi: 10.3390/genes8020071

Yan, Shunfei, Frank, Daniel, Son, Jinbae, Hannan, Katherine M., Hannan, Ross D., Chan, Keefe T., Pearson, Richard B. and Sanij, Elaine (2017). The potential of targeting ribosome biogenesis in high-grade serous ovarian cancer. International Journal of Molecular Sciences, 18 (1) 210, 210. doi: 10.3390/ijms18010210

Rebello, Richard J., Kusnadi, Eric, Cameron, Donald P., Pearson, Helen B., Lesmana, Analia, Devlin, Jennifer R., Drygin, Denis, Clark, Ashlee K., Porter, Laura, Pedersen, John, Sandhu, Shahneen, Risbridger, Gail P., Pearson, Richard B., Hannan, Ross D. and Furic, Luc (2016). The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer. Clinical Cancer Research, 22 (22), 5539-5552. doi: 10.1158/1078-0432.CCR-16-0124

Hung, Sandy S., Lesmana, Analia, Peck, Abigail, Lee, Rachel, Tchoubrieva, Elly, Hannan, Katherine M., Lin, Jane, Sheppard, Karen E., Jastrzebski, Katarzyna, Quinn, Leonie M., Rothblum, Lawrence I., Pearson, Richard B., Hannan, Ross D. and Sanij, Elaine (2016). Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription. Gene, 612, 36-48. doi: 10.1016/j.gene.2016.12.015

Chan, Keefe T., Paavolainen, Lassi, Hannan, Katherine M., George, Amee J., Hannan, Ross D., Simpson, Kaylene J., Horvath, Peter and Pearson, Richard B. (2016). Combining high-content imaging and phenotypic classification analysis of senescence-associated beta-galactosidase staining to identify regulators of oncogene-induced senescence. Assay and Drug Development Technologies, 14 (7), 416-428. doi: 10.1089/adt.2016.739

Quin, Jaclyn, Chan, Keefe T., Devlin, Jennifer R., Cameron, Donald P., Diesch, Jeannine, Cullinane, Carleen, Ahern, Jessica, Khot, Amit, Hein, Nadine, George, Amee J., Hannan, Katherine M., Poortinga, Gretchen, Sheppard, Karen E., Khanna, Kum Kum, Johnstone, Ricky W., Drygin, Denis, McArthur, Grant A., Pearson, Richard B., Sanij, Elaine and Hannan, Ross D. (2016). Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling. Oncotarget, 7 (31), 49800-49818. doi: 10.18632/oncotarget.10452

Kang, Jian, Kusnadi, Eric P., Ogden, Allison J., Hicks, Rodney J., Bammert, Lukas, Kutay, Ulrike, Hung, Sandy, Sanij, Elaine, Hannan, Ross D., Hannan, Katherine M. and Pearson, Richard B. (2016). Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription. Oncotarget, 7 (31), 48887-48904. doi: 10.18632/oncotarget.10346

Devlin, Jennifer R., Hannan, Katherine M., Hein, Nadine, Cullinane, Carleen, Kusnadi, Eric, Ng, Pui Yee, George, Amee J., Shortt, Jake, Bywater, Megan J., Poortinga, Gretchen, Sanij, Elaine, Kang, Jian, Drygin, Denis, O'Brien, Sean, Johnstone, Ricky W., McArthur, Grant A., Hannan, Ross D. and Pearson, Richard B. (2016). Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma. Cancer Discovery, 6 (1), 59-70. doi: 10.1158/2159-8290.CD-14-0673

Woods, Simone J., Hannan, Katherine M., Pearson, Richard B. and Hannan, Ross D. (2015). The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1849 (7), 821-829. doi: 10.1016/j.bbagrm.2014.10.007

Sheppard, Karen E., Pearson, Richard B. and Hannan, Ross D. (2015). Unexpected role of CDK4 in a G2/M checkpoint. Cell Cycle, 14 (9), 1351-1352. doi: 10.1080/15384101.2015.1022060

Diesch, Jeannine, Hannan, Ross D and Sanij, Elaine (2015). Genome wide mapping of UBF binding-sites in mouse and human cell lines. Genomics Data, 3, 103-105. doi: 10.1016/j.gdata.2014.12.005

Sanij, Elaine, Diesch, Jeannine, Lesmana, Analia, Poortinga, Gretchen, Hein, Nadine, Lidgerwood, Grace, Cameron, Donald P., Ellul, Jason, Goodall, Gregory J., Wong, Lee H., Dhillon, Amardeep S., Hamdane, Nourdine, Rothblum, Lawrence I., Pearson, Richard B., Haviv, Izhak, Moss, Tom and Hannan, Ross D. (2015). A novel role for the Pol I transcription factor TBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes. Genome Research, 25 (2), 201-212. doi: 10.1101/gr.176115.114

Kusnadi, Eric P., Hannan, Katherine M., Hicks, Rodney J., Hannan, Ross D., Pearson, Richard B. and Kang, Jian (2015). Regulation of rDNA transcription in response to growth factors, nutrients and energy. Gene, 556 (1), 27-34. doi: 10.1016/j.gene.2014.11.010

Diesch, Jeannine, Hannan, Ross D. and Sanij, Elaine (2014). Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease. Cell and Bioscience, 4 (1) 43, 43. doi: 10.1186/2045-3701-4-43

Quin, Jaclyn E., Devlin, Jennifer R., Cameron, Donald, Hannan, Kate M., Pearson, Richard B. and Hannan, Ross D. (2014). Targeting the nucleolus for cancer intervention. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1842 (6), 802-816. doi: 10.1016/j.bbadis.2013.12.009

Gilan, O., Diesch, J., Amalia, M., Jastrzebski, K., Chueh, A., Verrills, N. M., Pearson, R. B., Mariadason, J. M., Tulchinsky, E., Hannan, R. D. and Dhillon, A. S. (2014). PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity. Oncogene, 34 (10), 1-7. doi: 10.1038/onc.2014.26

Poortinga, G., Quinn, L. M. and Hannan, R. D. (2014). Targeting RNA polymerase I to treat MYC-driven cancer. Oncogene, 34 (4), 1-10. doi: 10.1038/onc.2014.13

Diesch, Jeannine, Sanij, Elaine, Gilan, Omer, Love, Christopher, Tran, Hoanh, Fleming, Nicholas I., Ellul, Jason, Amalia, Marcia, Haviv, Izhak, Pearson, Richard B., Tulchinsky, Eugene, Mariadason, John M., Sieber, Oliver M., Hannan, Ross D. and Dhillon, Amardeep S. (2014). Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells. PLoS One, 9 (3) e88950, e88950.1-e88950.11. doi: 10.1371/journal.pone.0088950

George, Amee J., Purdue, Brooke W., Gould, Cathryn M., Thomas, Daniel W., Handoko, Yanny, Qian, Hongwei, Quaife-Ryan, Gregory A., Morgan, Kylie A., Simpson, Kaylene J., Thomas, Walter G. and Hannan, Ross D. (2013). A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation. Journal of Cell Science, 126 (23), 5377-5390. doi: 10.1242/jcs.128280

Bruhn, Maressa A, Pearson, Richard B, Hannan, Ross D and Sheppard, Karen E (2013). AKT-independent PI3-K signaling in cancer - Emerging role for SGK3. Cancer Management and Research, 5 (1), 281-292. doi: 10.2147/CMAR.S35178

Hannan, Ross D., Drygin, Denis and Pearson, Richard B. (2013). Targeting RNA polymerase I transcription and the nucleolus for cancer therapy. Expert Opinion on Therapeutic Targets, 17 (8), 873-878. doi: 10.1517/14728222.2013.818658

Bywater, Megan J., Pearson, Richard B., McArthur, Grant A. and Hannan, Ross D. (2013). Dysregulation of the basal RNA polymerase transcription apparatus in cancer. Nature Reviews Cancer, 13 (5), 299-314. doi: 10.1038/nrc3496

Foster, Simon R., Porrello, Enzo R., Purdue, Brooke, Chan, Hsiu-Wen, Voigt, Anja, Frenzel, Sabine, Hannan, Ross D., Moritz, Karen M., Simmons, David G., Molenaar, Peter, Roura, Eugeni, Boehm, Ulrich, Meyerhof, Wolfgang and Thomas, Walter G. (2013). Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart. PLoS ONE, 8 (5) e64579, e64579-1-e64579-10. doi: 10.1371/journal.pone.0064579

Hannan, K. M., Sanij, E., Rothblum, L. I., Hannan, R. D. and Pearson, R. B. (2013). Dysregulation of RNA polymerase I transcription during disease. Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1829 (3-4), 342-360. doi: 10.1016/j.bbagrm.2012.10.014

Wall, Meaghan, Poortinga, Gretchen, Stanley, Kym L., Lindemann, Ralph K., Bots, Michael, Chan, Christopher J., Bywater, Megan J., Kinross, Kathryn M., Astle, Megan V., Waldeck, Kelly, Hannan, Katherine M., Shortt, Jake, Smyth, Mark J., Lowe, Scott W., Hannan, Ross D., Pearson, Richard B., Johnstone, Ricky W. and McArthur, Grant A. (2013). The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence. Cancer Discovery, 3 (1), 82-95. doi: 10.1158/2159-8290.CD-12-0404

Sheppard, Karen E., Cullinane, Carleen, Hannan, Katherine M., Wall, Meaghan, Chan, Joanna, Barber, Frances, Foo, Jung, Cameron, Donald, Neilsen, Amelia, Ng, Pui, Ellul, Jason, Kleinschmidt, Margarete, Kinross, Kathryn M., Bowtell, David D., Christensen, James G., Hicks, Rodney J., Johnstone, Ricky W., McArthur, Grant A., Hannan, Ross D., Phillips, Wayne A. and Pearson, Richard B. (2013). Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors. European Journal of Cancer, 49 (18), 3936-3944. doi: 10.1016/j.ejca.2013.08.007

Hein, Nadine, Hannan, Katherine M., George, Amee J., Sanij, Elaine and Hannan, Ross D. (2013). The nucleolus: An emerging target for cancer therapy. Trends in Molecular Medicine, 19 (11), 643-654. doi: 10.1016/j.molmed.2013.07.005

Bywater, Megan J., Poortinga, Gretchen, Sanij, Elaine, Hein, Nadine, Peck, Abigail, Cullinane, Carleen, Wall, Meaghan, Cluse, Leonie, Drygin, Denis, Anderes, Kenna, Huser, Nanni, Proffitt, Chris, Bliesath, Joshua, Haddach, Mustapha, Schwaebe, Michael K., Ryckman, David M., Rice, William G., Schmitt, Clemens, Lowe, Scott W., Johnstone, Ricky W., Pearson, Richard B., McArthur, Grant A. and Hannan, Ross D. (2012). Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell, 22 (1), 51-65. doi: 10.1016/j.ccr.2012.05.019

Astle, M. V., Hannan, K. M., Ng, P. Y., Lee, R. S., George, A. J., Hsu, A. K., Haupt, Y., Hannan, R. D. and Pearson, R. B. (2012). AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: Implications for targeting mTOR during malignancy. Oncogene, 31 (15), 1949-1962. doi: 10.1038/onc.2011.394

Lin, Jane I., Mitchell, Naomi C., Kalcina, Marina, Tchoubrieva, Elly, Stewart, Mary J., Marygold, Steven J., Walker, Cherryl d., Thomas, George, Leevers, Sally J., Pearson, Richard B., Quinn, Leonie M. and Hannan, Ross D. (2011). Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone. Plos Genetics, 7 (12) e1002408, e1002408.1-e1002408.8. doi: 10.1371/journal.pgen.1002408

Sanij, Elaine, Poortinga, Gretchen, Sharkey, Kerith, Hung, Sandy, Holloway, Timothy P., Ouin, Jaclyn, Robb, Elysia, Wong, Lee H., Thomas, Walter G., Stefanovsky, Victor, Moss, Tom, Rothblum, Lawrence, Hannan, Katherine M., McArthur, Grant A., Pearson, Richard B. and Hannan, Ross D. (2008). UBF levels determine the number of active ribosomal RNA genes in mammals. The Journal of Cell Biology, 183 (7), 1259-1274. doi: 10.1083/jcb.200805146

Bathgate, R. A. D., Lekgabe, E. D., McGuane, J. T., Su, Y., Pham, T., Ferraro, T., Layfield, S., Hannan, R. D., Thomas, W. G., Samuel, C. S. and Du, X.-J. (2008). Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis. Molecular and Cellular Endocrinology, 280 (1-2), 30-38. doi: 10.1016/j.mce.2007.09.008

Maclachlan, K., Cuddihy, A., Hein, N., Harrison, S. and Hannan, R. (2016). Combination Drug Therapies with the Novel Rna Polymerase I Inhibitor Cx-5461 Improve Efficacy in the Treatment of Multiple Myeloma. 21st Congress of the European-Hematology-Association, Copenhagen, Denmark, 9-12 June 2016. Pavia, Italy: Ferrata Storti Foundation.

George, Amee J., Hannan, Ross D. and Thomas, Walter G. (2013). Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches. The International Symposium ‘Ca2+ Signalling and Transport in Health and Disease’, Aarhus, Denmark, 19 - 20 June 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing Ltd.. doi: 10.1111/febs.12509

Devlin, Jennifer R., Hannan,Katherine M., Ng, Pui Y., Bywater, Megan J., Shortt, Jake, Cullinane, Carleen, McArthur, Grant A., Johnstone, Ricky W., Hannan, Ross D. and Pearson, Richard B. (2013). AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo. Ca2+ signalling and transport in health and disease, Aarhus, Denmark, 19 -20 June 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing Ltd.. doi: 10.1111/febs.12135

Chan, Hsiu-Wen, Jenkins, Anna, Pipolo, Luisa, Hannan, Ross D., Thomas, Walter G. and Smith, Nicola J. (2006). Effect of dominant-negative epidermal growth factor receptors on cardiomyocyte hypertrophy. 10th Swiss Receptor Workshop: "From Research to Therapeutics", Basel, Switzerland, 12-15 March 2006. New York, NY, U.S.A.: Marcel Dekker. doi: 10.1080/10799890600923187

Honorary Professor Ross Hannan

Publications

Journal Articles

Conference Papers