In the Bellingham Lab, we investigate the electrophysiology of synaptic transmission, ion currents and central pattern generation in CNS neurones

Current research focuses on the electrophysiology of central nervous system neurones using various in vitro slice preparations, patch clamp techniques, imaging, molecular biology and computer modelling.

Mechanisms of neurological disease:

  • Pathogenesis and treatment of motor neuron disease in animal models
  • Electrophysiology of neurotransmitter receptors and ion channels in motor neurons and other central neurons
  • Developmental changes in and mechanisms of short and long term synaptic plasticity
  • Neurobiology of addiction and relapse
  • Neurobiology of autism

Synaptic transmission:

  • Electrophysiology of neurotransmitter receptors and ion channels in motor neurons and other central neurons
  • Developmental changes in and mechanisms of short and long term synaptic plasticity

Neurotransmitter receptors and ion currents in CNS neurones:

  • Neurotransmitter receptor modulation of motor neurones - neuropharmacology and second messenger systems
  • Effects of anaethetic agents on motor neuron excitability

Rhythmic control of movements:

  • Role of glycine and GABA A receptors in programmed cell death of motor neurones and rhythmic movements
  • Studies of ion currents controlling rhythm generation and computer models of single neurones and rhythmic networks

Lab head

Find out more about our research environment and how to apply to do a short or long-term research project with us.