Centre for Integrated Preclinical Drug Development

• The role and treatment potential of the complement pathway in chronic pain

Vygonskaya, Marina, Wu, Youzhi, Price, Theodore J., Chen, Zhuo, Smith, Maree T., Klyne, David M., and Han, Felicity Y. (2024). The role and treatment potential of the complement pathway in chronic pain. The Journal of Pain 104689 104689. https://doi.org/10.1016/j.jpain.2024.104689

• J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine

Kuo, A., Imam, M. Z., Li, R., Lin, L., Raboczyj, A., Bohmer, A. E., Nicholson, J. R., Corradini, L., and Smith, M. T. (2024). J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine. Frontiers in Pharmacology 15 1346801. https://doi.org/10.3389/fphar.2024.1346801

• seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation

Kong, Dehui, Fahrenhorst-Jones, Tyler, Kuo, Andy, Simmons, Jacinta L., Tan, Lendl, Burns, Jed M., Pierens, Gregory K., Li, Rui, West, Nicholas P., Boyle, Glen M., Smith, Maree T., Savage, G. Paul, and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation. The Journal of Organic Chemistry 89 (1) 798-803. https://doi.org/10.1021/acs.joc.3c02333

• Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation

Shepherd, Andrew J., Rice, Andrew SC. and Smith, Maree T. (2023). Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation. Current Opinion in Pharmacology, 73 102415, 102415. doi: 10.1016/j.coph.2023.102415

• In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes

Imam, Mohammad Zafar, Ghassabian, Sussan, Kuo, Andy, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes. European Journal of Drug Metabolism and Pharmacokinetics, 48 (4), 463-466. doi: 10.1007/s13318-023-00828-6

• The NLRP3 inflammasome: role in the pathobiology of chronic pain

Chen, Chen and Smith, Maree T. (2023). The NLRP3 inflammasome: role in the pathobiology of chronic pain. Inflammopharmacology, 31 (4), 1589-1603. doi: 10.1007/s10787-023-01235-8

• Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effects

Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2023). Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effects. Journal of Medicinal Chemistry, 66 (6), 3746-3784. doi: 10.1021/acs.jmedchem.2c01695

• CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats

Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats. Pharmacological Reports, 75 (3), 634-646. doi: 10.1007/s43440-023-00446-8

• Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials

Smith, A. E., Muralidharan, A. and Smith, M. T. (2022). Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials. Discover Oncology, 13 (1) 108. doi: 10.1007/s12672-022-00569-z

• Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain

Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic & Medicinal Chemistry, 69 116889, 116889. doi: 10.1016/j.bmc.2022.116889

• Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy

Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics 2200109, 2200109. doi: 10.1002/adtp.202200109

• Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial

Smith, Maree T. (2022). Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial. Pain, Publish Ahead of Print (S1), S15-S28. doi: 10.1097/j.pain.0000000000002675

• Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat

Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree Therese (2022). Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat. Behavioural Pharmacology, 33 (1), 23-31. doi: 10.1097/fbp.0000000000000663

• Journey to the market: The evolution of biodegradable drug delivery systems

Zhu, Minze, Whittaker, Andrew K., Han, Felicity Y. and Smith, Maree T. (2022). Journey to the market: The evolution of biodegradable drug delivery systems. Applied Sciences, 12 (2) 935. doi: 10.3390/app12020935

• Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources

Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915

• Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice

Xu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3

• Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint

Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint. Clinical and Experimental Pharmacology and Physiology, 48 (11) 1440-1681.13551, 1515-1522. doi: 10.1111/1440-1681.13551

• Editorial: verification of animal pain models by reverse translation

Caudle, Robert M., Smith, Maree Therese and Romero-Sandoval, E. Alfonso (2021). Editorial: verification of animal pain models by reverse translation. Frontiers in Pharmacology, 12 778880, 778880. doi: 10.3389/fphar.2021.778880

• Optimisation of a microfluidic method for the delivery of a small peptide

Han, Felicity Y., Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria, Jiang, Xingyu, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2021). Optimisation of a microfluidic method for the delivery of a small peptide. Pharmaceutics, 13 (9) 1505, 1505. doi: 10.3390/pharmaceutics13091505

• Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy

Kuo, Andy, Corradini, Laura, Nicholson, Janet R. and Smith, Maree T. (2021). Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy. Biomolecules, 11 (7) 940, 1-17. doi: 10.3390/biom11070940

• Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process

Xu, Weizhi, Zhao, Zonglan, Falconer, James, Whittaker, Andrew K., Popat, Amirali, Smith, Maree T., Kumeria, Tushar and Han, Felicity Y. (2021). Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process. Drug Delivery and Translational Research, 12 (3), 676-694. doi: 10.1007/s13346-021-00991-w

• Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods

Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods. Clinical and Experimental Pharmacology and Physiology, 48 (1) 1440-1681.13402, 96-106. doi: 10.1111/1440-1681.13402

• Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain

Zhu, Minze, Whittaker, Andrew K., Jiang, Xingyu, Tang, Rupei, Li, Xuanyu, Xu, Weizhi, Fu, Changkui, Smith, Maree T. and Han, Felicity Y. (2020). Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain. Pharmaceutical Research, 37 (10) 211, 1-12. doi: 10.1007/s11095-020-02939-0

• Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris

Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229

• Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain

Imam, Mohammad Zafar, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2020). Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain. Pharmacological Reports, 72 (5), 1418-1425. doi: 10.1007/s43440-020-00145-8

• Assessment of the anti‐hyperalgesic efficacy of J‐2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP)

Kuo, Andy, Lourdesamy, Jacintha, Nicholson, Janet R., Corradini, Laura and Maree, Smith T. (2020). Assessment of the anti‐hyperalgesic efficacy of J‐2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP). Clinical and Experimental Pharmacology and Physiology, 47 (12) 1440-1681.13383, 1912-1922. doi: 10.1111/1440-1681.13383

• Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease

Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease. Clinical and Experimental Pharmacology and Physiology, 47 (10) 1440-1681.13363, 1740-1750. doi: 10.1111/1440-1681.13363

• Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation

Han, Felicity Y., Liu, Yun, Kumar, Vinod, Xu, Weizhi, Yang, Guangze, Zhao, Chun-Xia, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581 119291, 119291. doi: 10.1016/j.ijpharm.2020.119291

• In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile

Kuo, Andy, Magiera, Julia, Rethwan, Nursyazwani, Andersson, Åsa, Leen Lam, Ai, Wyse, Bruce, Meutermans, Wim, Lewis, Richard and Smith, Maree (2020). In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. European Journal of Pharmacology, 872 172947, 172947. doi: 10.1016/j.ejphar.2020.172947

• Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine

Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2020). Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine. European Journal of Pharmacology, 871 172918, 172918. doi: 10.1016/j.ejphar.2020.172918

• Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants

Imam, Mohammad Zafar, Kuo, Andy and Smith, Maree T. (2020). Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants. F1000Research, 9 91, 91. doi: 10.12688/f1000research.21738.1

• Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain

Shenoy, Priyank A., Kuo, Andy, Leparc, German, Hildebrandt, Tobias, Rust, Werner, Nicholson, Janet R., Corradini, Laura, Vetter, Irina and Smith, Maree T. (2019). Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain. Clinical and Experimental Pharmacology and Physiology, 46 (12) 1440-1681.13165, 1201-1215. doi: 10.1111/1440-1681.13165

• J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain

Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain. Biomedicine and Pharmacotherapy, 117 109056, 109056. doi: 10.1016/j.biopha.2019.109056

• The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

Houston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a

• Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy

Adiraju, Santosh Kumar Sreevatsav, Shekar, Kiran, Tesar, Peter, Naidoo, Rishendran, Rapchuk, Ivan, Belz, Stephen, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2019). Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy. Methods and Protocols, 2 (2) 38, 38-12. doi: 10.3390/mps2020038

• Nitric oxide modulates μ‐opioid receptor function in vitro

Huang, Lillian, Wyse, Bruce D., Williams, Craig M. and Smith, Maree T. (2019). Nitric oxide modulates μ‐opioid receptor function in vitro. Clinical and Experimental Pharmacology and Physiology, 46 (7) 1440-1681.13091, 676-685. doi: 10.1111/1440-1681.13091

• Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods

Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods. Inflammopharmacology, 27 (2), 387-396. doi: 10.1007/s10787-018-00551-8

• Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology

Zhu, Minze, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2019). Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology. Journal of Pharmaceutical Sciences, 108 (3), 1220-1226. doi: 10.1016/j.xphs.2018.10.029

• Cyclooctatetraene: a bioactive cubane paradigm complement

Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277

• Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation

Han, Felicity Y., Whittaker, Andrew, Howdle, Steven M., Naylor, Andrew, Shabir-Ahmed, Anjumn and Smith, Maree T. (2019). Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation. Journal of Pharmaceutical Sciences, 108 (2), 811-814. doi: 10.1016/j.xphs.2018.09.021

• Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation

Han, Felicity, Whittaker, Andrew, Howdle, Steven, Naylor, Andrew, Shabir-Ahmed, Anjumn, Zhang, Cheng and Smith, Maree (2018). Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation. Pharmaceutics, 10 (4) 264, 264. doi: 10.3390/pharmaceutics10040264

• An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity

Sreevatsav Adiraju, Santosh Kumar, Shekar, Kiran, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2018). An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity. Bioanalysis, 10 (19), 1577-1590. doi: 10.4155/bio-2018-0102

• Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675)

Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161

• Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain : a cross-sectional pilot study

Richards, Georgia C., Lluka, Lesley J., Smith, Maree T., Haslam, Catherine, Moore, Brendan, OʼCallaghan, James and Strong, Jenny (2018). Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain : a cross-sectional pilot study. PAIN Reports, 3 (4) e669, e669. doi: 10.1097/pr9.0000000000000669

• In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: between colony differences in Sprague Dawley rats

Kuo, Andy and Smith, Maree T. (2018). In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: between colony differences in Sprague Dawley rats. Clinical and Experimental Pharmacology & Physiology, 45 (10), 1056-1066. doi: 10.1111/1440-1681.12972

• Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy

Han, Felicity Y., Kuo, Andy, Nicholson, Janet R., Corradinni, Laura and Smith, Maree T. (2018). Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy. Clinical and Experimental Pharmacology and Physiology, 45 (10), 1067-1075. doi: 10.1111/1440-1681.12971

• Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data

Park, Thomas S. W., Kuo, Andy and Smith, Maree T. (2018). Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data. Inflammopharmacology, 26 (4), 1-18. doi: 10.1007/s10787-018-0493-x

• The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain

Shenoy, Priyank A., Kuo, Andy, Khan, Nemat, Gorham, Louise, Nicholson, Janet, Corradini, Laura, Vetter, Irina and Smith, Maree T. (2018). The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain. Frontiers in Pharmacology, 9 (MAY) 495, 495. doi: 10.3389/fphar.2018.00495

• An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma

Moosavi, Seyed Mojtaba, Shekar, Kiran, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2018). An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1073, 118-122. doi: 10.1016/j.jchromb.2017.12.006

• Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain

Lee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089

• Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls

Qin, Yajuan, Ni, Luofan, Shi, Jiawei, Zhu, Zhiying, Shi, Saijian, Lam, Ai-Leen, Magiera, Julia, Sekar, Sunderajhan, Kuo, Andy, Smith, Maree T. and Li, Tingyou (2018). Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls. ACS Chemical Neuroscience, 10 (1) acschemneuro.8b00363, 201-208. doi: 10.1021/acschemneuro.8b00363

• Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression

Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan and Smith, Maree T. (2017). Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression. Neuropharmacology, 131, 238-255. doi: 10.1016/j.neuropharm.2017.12.032

• Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy

Adiraju, Santosh Kumar Sreevatsav, Shekar, Kiran, Fraser, John F, Smith, Maree T and Ghassabian, Sussan (2017). Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy. Drug metabolism reviews, 50 (2), 1-16. doi: 10.1080/03602532.2017.1417423

• Morphine hyposensitivity in STZ-diabetic rats: reversal by dietary L-arginine treatment

Lotfipour, Shahrdad and Smith, Maree T. (2017). Morphine hyposensitivity in STZ-diabetic rats: reversal by dietary L-arginine treatment. Clinical and Experimental Pharmacology & Physiology, 45 (1), 42-49. doi: 10.1111/1440-1681.12855

• Attenuation of the Infiltration of Angiotensin II Expressing CD3+ T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia – A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT2) Receptor Antagonist

Nemat Khan, Arjun Muralidharan and Maree T. Smith (2017)

• Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain

Nemat Khan1, Andy Kuo1,  David A. Brockman,  Matthew A. Cooper, Maree T. Smith (2017)

• Morphine hyposensitivity in STZ-diabetic rats: reversal by dietary L-arginine treatment

Lotfipour, Shahrdad and Smith, Maree T. (2017) 

• Establishment and Characterization of a Novel Rat Model of Mechanical Low Back Pain Using Behavioral, Pharmacologic and Histologic Methods

Arjun Muralidharan^1†, Thomas S. W. Park^1†, John T. Mackie², Luiz G. S. Gimenez¹, Andy Kuo¹, Janet R. Nicholson³, Laura Corradini³ and Maree T. Smith* (2017).

• Optimization and In Vivo Profiling of a Refined Rat Model of Walker 256 Breast Cancer Cell-Induced Bone Pain Using Behavioral, Radiological, Histological, Immunohistochemical and Pharmacological Methods

Priyank Shenoy^1,2, Andy Kuo¹, Irina Vetter^3,4 and Maree T. Smith* (2017)

• High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation

Seyed Mojtaba Moosavi, Kiran Shekar, John Fraser, Maree T. Smith, Sussan Ghassabian (2016). High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation. Journal of Chromatography B, http://dx.doi.org/10.1016/j.jchromb.2016.10.038

• The Walker 256 breast cancer cell-induced bone pain model in rats

Shenoy, Priyank A., Kuo, Andy, Vetter, Irina and Smith, Maree T. (2016) The Walker 256 breast cancer cell-induced bone pain model in rats. Frontiers in Pharmacology, 7 AUG: . doi:10.3389/fphar.2016.00286

• Bioerodable PLGA-Based Microparticles for Producing Sustained-Release Drug Formulations and Strategies for Improving Drug Loading

Han FY, Thurecht KJ, Whittaker AK and Smith MT (2016). Bioerodable PLGA-Based Microparticles for Producing Sustained-Release Drug Formulations and Strategies for Improving Drug Loading. Front. Pharmacol 7:185. doi: 10.3389/fphar.2016.00185

• Comparison of burrowing and stimuli-evoked pain behaviors as end-points in rat models of inflammatory pain and peripheral neuropathic pain

Muralidharan, Arjun, Kuo, Andy, Jacob, Meera, Lourdesamy, Jacintha S., Melo Sores Pinho De Carvalho, Lara, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2016) Comparison of burrowing and stimuli-evoked pain behaviors as end-points in rat models of inflammatory pain and peripheral neuropathic pain. Frontiers in Behavioral Neuroscience, 10 88: . doi:10.3389/fnbeh.2016.00088

• In Vitro Metabolic Stability and in Vivo Biodistribution of 3‑Methyl-4- furoxancarbaldehyde Using PET Imaging in Rats

Pippi, Adam B., Mohd Arshad, Zaira Hidayah, Vol, Ronald J., Nye, Jonathon A., Ghassabian, Sussan, Williams, Craig M., Mancini, Alessandra, Liotta, Dennis C., Smith, Maree T. and Goodman, Mark M. (2016) In Vitro Metabolic Stability and in Vivo Biodistribution of 3‑Methyl-4- furoxancarbaldehyde Using PET Imaging in Rats. ACS Medicinal Chemistry Letters, . doi:10.1021/acsmedchemlett.5b00410

• Evaluation of a high-throughput peptide reactivity format assay for assessment of the skin sensitization potential of chemicals

Wong, Chin Lin, Lam, Ai Leen, Smith, Maree T. and Ghassabian, Sussan (2016) Evaluation of a high-throughput peptide reactivity format assay for assessment of the skin sensitization potential of chemicals. Frontiers in Pharmacology, 7 MAR: . doi:10.3389/fphar.2016.00053

• Validating Eaton's hypothesis: cubane as a benzene bioisostere

Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016) Validating Eaton's hypothesis: cubane as a benzene bioisostere. Angewandte Chemie (International Edition), 55 11: 3580-3585. doi:10.1002/anie.201510675

• Selective small molecule angiotensin II type 2 (AT2) receptor antagonists for neuropathic pain: preclinical and clinical studies

Smith, Maree T., Anand, Praveen and Rice, Andrew S. C. (2016) Selective small molecule angiotensin II type 2 (AT2) receptor antagonists for neuropathic pain: preclinical and clinical studies. Pain, 157 Supplement 1: S33-S41. doi:10.1097/j.pain.0000000000000369

• Why different pain-killers are only effective for certain types of pain

Smith, Maree (2015) Why different pain-killers are only effective for certain types of pain. The Conversation, .

• A novel fully validated LC-MS/MS method for quantification of pyridoxal-5'-phosphate concentrations in samples of human whole blood

Ghassabian, Sussan, Griffiths, Lyn and Smith, Maree T (2015) A novel fully validated LC-MS/MS method for quantification of pyridoxal-5'-phosphate concentrations in samples of human whole blood.Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1000 77-83. doi:10.1016/j.jchromb.2015.07.019

• Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain

Han, Felicity Y., Thurecht, Kristofer J., Lam, Ai-Leen, Whittaker, Andrew K. and Smith, Maree T. (2015) Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. Journal of Pharmaceutical Sciences, 1047: 2334-2344. doi:10.1002/jps.24497

• Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture, TPM) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure

Smith, Maree T., Wyse, Bruce D., Edwards, Stephen R., El-Taminy, Mahmoud, Gaetano, Giacinto and Gavin, Paul (2015) Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture, TPM) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure. Journal of Pharmaceutical Sciences, 104 7: 2388-2396. doi:10.1002/jps.24502

• The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN)

Huang, Lillian Y., Tsui, Debbie Y., Williams, Craig M., Wyse, Bruce D. and Smith, Maree T. (2015) The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN). Clinical and Experimental Pharmacology and Physiology, 42 9: 921-929. doi:10.1111/1440-1681.12442

• In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla

Alomair, Othman I, Brereton, Ian M, Smith, Maree T, Galloway, Graham J and Kurniawan, Nyoman D (2015) In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla. Plos One, 10 6: . doi:10.1371/journal.pone.0130133

• Neurotrophins and neuropathic pain: role in pathobiology

Khan, Nemat and Smith, Maree T. (2015) Neurotrophins and neuropathic pain: role in pathobiology.Molecules, 20 6: 10657-10688. doi:10.3390/molecules200610657

• Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord

Khan, Nemat, Gordon, Richard, Woodruff, Trent M. and Smith, Maree T. (2015) Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord.Pharmacology Research and Perspectives, 3 3: 1-16. doi:10.1002/prp2.137

• In vitro methods for hazard assessment of industrial chemical - opportunities and challenges

Wong, Chin Lin, Ghassabian, Sussan, Smith, Maree T. and Lam, Ai-Leen (2015) In vitro methods for hazard assessment of industrial chemical - opportunities and challenges. Frontiers in Pharmacology, 694: 1-13. doi:10.3389/fphar.2015.00094

• Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain

Rice, A. S. C. and Smith, M. T. (2015) Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain. Clinical Pharmacology and Therapeutics, 97 2: 128-130. doi:10.1002/cpt.29

• Fully validated LC–MS/MS method for quantification of homocysteine concentrations in samples of human serum: a new approach

Ghassabian, Sussan, Rethwan, Nur Syazwani Ahmad, Griffiths, Lyn and Smith, Maree T. (2014) Fully validated LC–MS/MS method for quantification of homocysteine concentrations in samples of human serum: a new approach. Journal of Chromatography B, 972 14-21. doi:10.1016/j.jchromb.2014.09.032

• Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods

Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014) Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126 13-27. doi:10.1016/j.pbb.2014.09.003

• Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain

Han, Felicity Yaqin, Wyse, Bruce D. and Smith, Maree T. (2014) Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain. Behavioural Pharmacology, 25 8: 732-740. doi:10.1097/FBP.0000000000000090

• Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain

Smith, Maree T. and Muralidharan, Arjun (2014) Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain. Expert Opinion On Therapeutic Targets, 19 1: 25-35. doi:10.1517/14728222.2014.957673

• Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease

Edwards, Stephen R., Hamlin, Adam S., Marks, Nicola, Coulson, Elizabeth J. and Smith, Maree T. (2014) Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 41 10: 798-806. doi:10.1111/1440-1681.12277

• Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review

Kuo, Andy and Smith, Maree T. (2014) Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review. Journal of Neuroscience Methods, 233 166-171. doi:10.1016/j.jneumeth.2014.06.006

• Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy

Smith, Maree T., Lau, Tanya, Wallace, Victoria C. J., Wyse, Bruce D. and Rice, Andrew S. C. (2014) Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy. Behavioural Pharmacology, 25 2: 137-146. doi:10.1097/FBP.0000000000000025

• Endomorphin analogues with mixed mu-opioid (MOP) receptor agonism/delta-opioid (DOP) receptor antagonism and lacking beta-arrestin2 recruitment activity

Cai, Jun, Song, Bowen, Cai, Yunxin, Ma, Yu, Lam, Ai-leen, Magiera, Julia, Sekar, Sunder, Wyse, Bruce D., Ambo, Akihiro, Sasaki, Yusuke, Lazarus, Lawrence H., Smith, Maree T. and Li, Tingyou (2014) Endomorphin analogues with mixed mu-opioid (MOP) receptor agonism/delta-opioid (DOP) receptor antagonism and lacking beta-arrestin2 recruitment activity. Biorganic and Medicinal Chemistry, 22 7: 2208-2219. doi:10.1016/j.bmc.2014.02.015

• In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile

Kuo, A., Wyse, B. D., Meutermans, W. and Smith, M. T. (2014) In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. British Journal of Pharmacology, Accepted Article 1-48. doi:10.1111/bph.12696

• Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain

Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2014) Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain. Pain Medicine, 15 1: 93-110. doi:10.1111/pme.12258

• Current developments in MRI for assessing rodent models of multiple sclerosis

Alomair, Othman I., Smith, Maree T., Brereton, Ian M., Galloway, Graham J. and Kurniawan, Nyoman D. (2014) Current developments in MRI for assessing rodent models of multiple sclerosis. Future Neurology, 9 4: 487-511. doi:10.2217/FNL.14.33

• Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN)

Han, Yaqin and Smith, Maree T. (2013) Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN). Frontiers in Pharmacology, 4 1-16. doi:10.3389/fphar.2013.00156

• Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models

Khan, Nemat and Smith, Maree T. (2013) Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology, 22 1: 1-22. doi:10.1007/s10787-013-0195-3

• Comment On "protective Arms of the Renin-Angiotensin System in Neurological Disease"

Smith, Maree T. and Muralidharan, Arjun (2013) Comment On "protective Arms of the Renin-Angiotensin System in Neurological Disease". Clinical and Experimental Pharmacology and Physiology,40 11: 838-838. doi:10.1111/1440-1681.12169

• Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments

Muralidharan, Arjun and Smith, Maree T. (2013) Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments. Inflammopharmacology, 21 5: 339-363. doi:10.1007/s10787-013-0183-7

• A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia

Smith, Maree T., Woodruff, Trent M., Wyse, Bruce D., Muralidharan, Arjun and Walther, Thomas (2013) A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Medicine, 14 10: 1557-1568. doi:10.1111/pme.12157

• Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats

Smith, Maree T., Wyse, Bruce D. and Edwards, Stephen R. (2013) Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats. Pain Medicine, 14 5: 692-705. doi:10.1111/pme.12063

• Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation

Varamini, Pegah, Goh, Wei Huang, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2013) Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. Bioorganic & Medicinal Chemistry, 21 7: 1898-1904. doi:10.1016/j.bmc.2013.01.044

• The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation

Shekar, Kiran, Roberts, Jason A., Smith, Maree T., Fung, Yoke L. and Fraser, John F. (2013) The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation. BMC Anesthesiology, 13 7.1-7.10. doi:10.1186/1471-2253-13-7

• Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods

Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2013) Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 106 33-46. doi:10.1016/j.pbb.2013.02.020

• ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO

Shekar, Kiran, Roberts, Jason A., Welsh, Susan, Buscher, Hergen, Rudham, Sam, Burrows, Fay, Ghassabian, Sussan, Wallis, Steven C., Levkovich, Bianca, Pellegrino, Vin, McGuiness, Shay, Parke, Rachael, Gilder, Eileen, Barnett, Adrian G., Walsham, James, Mullany, Daniel V., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012) ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiology, 12 29.1-29.9. doi:10.1186/1471-2253-12-29

• Sedation during extracorporeal membrane oxygenation-why more is less

Shekar, K., Roberts, J. A., Ghassabian, S., Mullany, D. V., Ziegenfuss, M., Smith, M. T., Fung, Y. L. and Fraser, J. F. (2012) Sedation during extracorporeal membrane oxygenation-why more is less.Anaesthesia and Intensive Care, 40 6: 1067-1069.

• Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?

Shekar, Kiran, Roberts, Jason A., Ghassabian, Sussan, Mullany, Daniel V., Wallis, Steven C., Smith, Maree T. and Fraser, John F. (2012) Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?. Journal of Antimicrobial Chemotherapy, 68 3: 726-727. doi:10.1093/jac/dks435

• Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation

Shekar, Kiran, Roberts, Jason A., McDonald, Charles I., Fisquet, Stephanie, Barnett, Adrian G., Mullany, Daniel V., Ghassabian, Sussan, Wallis, Steven C., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012) Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Critical Care, 16 5: R194.1-R194.7. doi:10.1186/cc11679

• Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation

Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012) Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One, 7 8 Article. No.e41909: . doi:10.1371/journal.pone.0041909

• High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS

Ghassabian, Sussan, Moosavi, Seyed Mojtaba, Valero, Yarmarly Guerra, Shekar, Kiran, Fraser, John F. and Smith, Maree T. (2012) High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. Journal of Chromatography B, 903 126-133. doi:10.1016/j.jchromb.2012.07.005

• Pregabalin for the treatment of fibromyalgia

Smith, Maree T. and Moore, Brendan J. (2012) Pregabalin for the treatment of fibromyalgia. Expert Opinion on Pharmacotherapy, 13 10: 1527-1533. doi:10.1517/14656566.2012.687373

• Synthesis and biological evaluation of an orally active glycosylated endomorphin-1

Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012) Synthesis and biological evaluation of an orally active glycosylated endomorphin-1. Journal of Medicinal Chemistry, 55 12: 5859-5867. doi:10.1021/jm300418d

• Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions

Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I, Dunster, Kimble R., Fisquet, Kimble R, Platts, David G., Stewart, David G, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012) Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 2: 105-111.

• Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma

Ghassabian, Sussan, Wright, Linda A., deJager, Andrew D. and Smith, Maree T. (2012) Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 881-82 34-41. doi:10.1016/j.jchromb.2011.11.031

• Pharmacogenetics of pain and analgesia

Smith, M. T. and Muralidharan, A. (2012) Pharmacogenetics of pain and analgesia. Clinical Genetics,82 4: 321-330. doi:10.1111/j.1399-0004.2012.01936.x

• Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation

Shekar, Kiran, Fraser, John F., Smith, Maree T. and Roberts, Jason A. (2012) Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. Journal of Critical Care, 27 6: 741.e9-741.e18. doi:10.1016/j.jcrc.2012.02.013

• Pain, analgesia and genetics

Muralidharan, Arjun and Smith, Maree T. (2011) Pain, analgesia and genetics. Journal of Pharmacy and Pharmacology, 63 11: 1387-1400. doi:10.1111/j.2042-7158.2011.01340.x

• Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial

Gray, Paul, Kirby, Julie, Smith, Maree T., Cabot, Peter J., Williams, Bronwyn, Doecke, James and Cramond, Tess (2011) Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial. Pain, 152 6: 1279-1288. doi:10.1016/j.pain.2011.01.055

• Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats

Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011) Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. Pain Medicine, 12 5: 782-793. doi:10.1111/j.1526-4637.2011.01102.x

• Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months

Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011) Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months. Pain Medicine,12 3: 437-450. doi:10.1111/j.1526-4637.2011.01067.x

• PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

Dredge, K, Hammond, E, Handley, P, Gonda, TJ, Smith, MT, Vincent, C, Brandt, R, Ferro, V and Bytheway, I (2011) PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. British Journal of Cancer, 104 5: 635-642. doi:10.1038/bjc.2011.11

• Pharmacogenetics

Smith, Maree T. and Muralidharan, Arjun (2010) Pharmacogenetics. Pain: Clinical Updates, 18 8: 1-8.

• A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin

Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Duffull, Stephen B., Smith, Maree T. and Moore, Brendan J. (2010) A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. Journal of Pain, 11 5: 462-471. doi:10.1016/j.jpain.2009.09.003

• Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management

Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Moore, Brendan J. and Smith, Maree T. (2010) Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management. Pain Medicine, 11 4: 550-561. doi:10.1111/j.1526-4637.2010.00821.x

• X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

Brust, Andreas, Palant, Elka, Croker, Daniel E., Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I., Wilson, David, Nielsen, Carsten K., Smith, Maree T., Alewood, Danne, Alewood, Paul F and Lewis, Richard J. (2009) X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry,52 22: 6991-7002. doi:10.1021/jm9003413

• Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests

South, Samantha M., Edwards, Stephen R. and Smith, Maree T. (2009) Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests. Clinical and Experimental Pharmacology and Physiology, 36 1: 20-28. doi:10.1111/j.1440-1681.2008.05019.x

• Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration

Hemstapat, K., Le, L., Edwards, S. R. and Smith, M. T. (2009) Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration. Pharmacology, Biochemistry and Behaviour, 93 4: 498-505. doi:10.1016/j.pbb.2009.06.016

• Innovation in drug development

Smith, M.T. (2009) Innovation in drug development. BioSpectrum Asia CRAMS Resources Guide, 52-53.

• Differences between and combinations of opiods re-visited

Smith, Maree T. (2008) Differences between and combinations of opiods re-visited. Current Opinion in Anaesthesiology, 21 5: 596-601. doi:10.1097/ACO.0b013e32830a4c4a

• An update on the pharmcological management of post-herpetic neuralgia and painful diabetic neuropathy

Zin, Che S., Nissen, Lisa M., Smith, Maree T., O'Callaghan, James P. and Moore, Brendan J. (2008) An update on the pharmcological management of post-herpetic neuralgia and painful diabetic neuropathy.CNS Drugs, 22 5: 417-442.

• Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat

Chan, S., Edwards, S. R., Wyse, B. D. and Smith, M. T. (2008) Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat.Clinical and Experimental Pharmacology and Physiology, 35 3: 295-302. doi:10.1111/j.1440-1681.2007.04821.x

• Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats

Edwards, S. R., Mather, L. E. and Smith, M. T. (2007) Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats. Clinical and Experimental Pharmacology and Physiology, 34 5-6: 414-420. doi:10.1111/j.1440-1681.2007.04581.x

• Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry

Edwards, Stephen R. and Smith, Maree T. (2007) Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B,848 2: 264-270. doi:10.1016/j.jchromb.2006.10.039

• Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain

Nielsen, Carsten K., Ross, Fraser B., Lotfipour, Shahrdad, Saini, Kamal S., Edwards, Stephen R. and Smith, Maree T. (2007) Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain, 132 3: 289-300. doi:10.1016/j.pain.2007.03.022

• Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration

Smith, Maree T., Edwards, Stephen R. and Nielsen, Carsten K. (2007) Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration. Anesthesiology, 1065: 1063-1064. doi:10.1097/01.anes.0000265176.75372.ed

• Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

Nielsen, Carsten K., Lewis, Richard J., Alewood, Dianne, Drinkwater, Roger, Palant, Elka, Patterson, Margaret, Yaksh, Tony L, McCumber, Damon and Smith, Maree T. (2005) Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain, 118 1-2: 112-124. doi:10.1016/j.pain.2005.08.002

• Co-administration of oxycodone and morphine and analgesic synergy re-examined

Smith, MT and de la Iglesia, FA (2005) Co-administration of oxycodone and morphine and analgesic synergy re-examined. British Journal of Clinical Pharmacology, 59 4: 486-487. doi:10.1111/j.1365-2125.2005.02345_1.x

• Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes

Huang, L., Edwards, S. R. and Smith, M. T. (2005) Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes. Pharmaceutical Research, 22 9: 1489-1498. doi:10.1007/s11095-005-6154-y

• Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry

Edwards, S. R. and Smith, M. T. (2005) Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B,814 2: 241-249. doi:10.1016/j.jchromb.2004.10.035

• Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions

Ladd, L. A., Kam, P. C., Williams, D. B., Wright, A. W. E., Smith, M. T. and Mather, L. E. (2005) Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions. British Journal of Clinical Pharmacology, 59 5: 524-535. doi:10.1111/j.1365-2125.2005.02368.x

• Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine

Leck, KJ, Bartlett, SE, Smith, MT, Megirian, D, Holgate, J, Powell, KL, Matthaei, KI and Hendry, IA (2004) Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine. Neuropharmacology, 46 6: 836-846. doi:10.1016/j.neuropharm.2003.11.024

• Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screeningHemstapat, K, Smith, M. T. and Monteith, G. R. (2004) Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening. Journal of Pharmacological and Toxicological Methods, 49 2: 81-87. doi:10.1016/j.vascn.2003.10.002
• Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones 

Hemstapat, K., Monteith, G. R., Smith, D. and Smith, M. T. (2003) Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones. Anesthesia & Analgesia, 97 2: 494-505. doi:10.1213/01.ANE.0000059225.40049.99

• Managing diabetic neuropathy

Smith, M. T. (2003) Managing diabetic neuropathy. Australian Pharmacist, 22 10: 782-787.

• The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones

Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2003) The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. Pharmacology & Toxicology, 93 4: 197-200. doi:10.1034/j.1600-0773.2003.930408.x

• The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes

Wei, M., Ong, L., Smith, M. T., Ross, F. B., Schmid, K., Hoey, A., Burstow, D. J. and Brown, L. C. (2003) The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes.Heart, Lung and Circulation, 2003 12: 44-50.

• The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.

Smith, M. T., Cabot, P. J., Ross, F. B., Robertson, A. D. and Lewis, R. J. (2002) The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.. Pain, 96 1-2: 119-127. doi:10.1016/S0304-3959(01)00436-5

• Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance

South, Samantha M., Wright, Andrew W. E., Lau, Michael, Mather, Laurence E. and Smith, Maree T. (2001) Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance.Journal of Pharmacology and Experimental Therapeutics, 297 1: 446-457.

• Analgesic tolerance to opioids

South, S. M. and Smith, M. T. (2001) Analgesic tolerance to opioids. Pain: Clinical Updates, 9 5: 1-4.

• Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide

Wright, AWE, Mather, LE and Smith, MT (2001) Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide. Life Sciences, 69 4: 409-420. doi:10.1016/S0024-3205(01)01133-X

• Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital

Nissen, L. M., Tett, S. E., Cramond, T., Williams, B. and Smith, M. T. (2001) Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital. British Journal of Clinical Pharmacology, 52 6: 693-698. doi:10.1046/j.0306-5251.2001.01502.x

• The role of morphine-6-glucuronide (M6G) in pain control

Smith, Maree T. and South, Samantha M. (2001) The role of morphine-6-glucuronide (M6G) in pain control. Pain Reviews, 8 3-4: 171-191. doi:10.1191/0968130201pr183ra

• Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats

Ross, Fraser B., Wallis, Steven C. and Smith, Maree T. (2000) Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain, 84 2-3: 421-428. doi:10.1016/S0304-3959(99)00230-4

• Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat

Nielsen, C. K., Ross, F. B. and Smith, M. T. (2000) Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. Journal of Pharmacology and Experimental Therapeutics, 295 1: 91-99.

• Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites

Smith, MT (2000) Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites. Clinical and Experimental Pharmacology and Physiology, 27 7: 524-528. doi:10.1046/j.1440-1681.2000.03290.x

• Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats

Smith, M. T., Nielsen, C. K., Lim-Fraser, M. Y. C., Wright, A. W. E. and Lau, M. (2000) Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats. Drug Metabolism And Disposition, 28 2: 236-244.

• Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide

Halliday, Andrew J., Bartlett, Selena E., Colditz, Paul and Smith, Maree T. (1999) Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide. Life Sciences, 65 2: 225-236. doi:10.1016/S0024-3205(99)00239-8

• Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management

Smith, M. T., Wright, A. W., Williams, B., Stuart, G. and Cramond, T. R. (1999) Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management. Anesthesia and analgesia, 88 1: 109-116. doi:10.1097/00000539-199901000-00021

• Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

Keates, Helen L., Cramond, Teresa and Smith, Maree T. (1999) Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 2: 409-415.

• Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

Keates, HL, Cramond, T and Smith, MT (1999) Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 2: 409-415. doi:10.1097/00000539-199908000-00030

• Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats

South, SM and Smith, MT (1998) Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats. Journal of Pharmacology And Experimental Therapeutics, 286 3: 1326-1332.

• Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation

Wright, AWE, Nocente, ML and Smith, MT (1998) Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation. Life Sciences, 63 5: 401-411. doi:10.1016/S0024-3205(98)00288-4

• Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection

Wright, AWE and Smith, MT (1998) Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection. Therapeutic Drug Monitoring, 20 2: 215-218. doi:10.1097/00007691-199804000-00013

• Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats

Preechagoon, D, Smith, MT and Prankerd, RJ (1998) Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats. International Journal of Pharmaceutics, 163 1-2: 191-201. doi:10.1016/S0378-5173(97)00380-3

• Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma

Wright, AWE, Lawrence, JA, Iu, M, Cramond, T and Smith, MT (1998) Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma. Journal of Chromatography B, 712 1-2: 169-175. doi:10.1016/S0378-4347(98)00146-7

• The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats

Smith, GD and Smith, MT (1998) The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats. Journal of Pharmacology And Experimental Therapeutics, 285 3: 1157-1162.

• Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide

Smith, GD, Prankerd, RJ and Smith, MT (1997) Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide. Life Sciences, 61 2: 95-104. doi:10.1016/S0024-3205(97)00364-0

• Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways

Cabot, PJ, Cramond, T and Smith, MT (1997) Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways. Pulmonary Pharmacology & Therapeutics,10 4: 215-221. doi:10.1006/pupt.1997.0094

• The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated

Ross, FB and Smith, MT (1997) The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated. Pain, 73 2: 151-157. doi:10.1016/S0304-3959(97)00093-6

• Quantitative autoradiography of peripheral opioid binding sites in rat lung

Cabot, PJ, Cramond, T and Smith, MT (1996) Quantitative autoradiography of peripheral opioid binding sites in rat lung. European Journal of Pharmacology, 310 1: 47-53. doi:10.1016/0014-2999(96)00363-9

• Pharmacology of Morphine and Morphine-3-Glucuronide At Opioid, Excitatory Amino-Acid, Gaba and Glycine Binding-Sites

Bartlett, SE, Dodd, PR and Smith, MT (1994) Pharmacology of Morphine and Morphine-3-Glucuronide At Opioid, Excitatory Amino-Acid, Gaba and Glycine Binding-Sites. Pharmacology & Toxicology, 75 2: 73-81.

• Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung

Cabot, PJ, Dodd, PR, Cramond, T and Smith, MT (1994) Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung. European Journal of Pharmacology-Molecular Pharmacology Section, 268 2: 247-255. doi:10.1016/0922-4106(94)90195-3