Professor Marc Ruitenberg

Harvey, Alan R., Ehlert, Erich, de Wit, Joris, Drummond, Eleanor S., Pollett, Margaret A., Ruitenberg, Marc J., Plant, Giles W., Verhaagen, Joost and Levelt, Christiaan N. (2009). Use of GFP to analyze morphology, connectivity, and function of cells in the central nervous system. Viral Applications of Green Fluorescent Protein: Methods and Protocols. (pp. 63-95) edited by Barry W. Hicks. New York, USA: Humana. doi: 10.1007/978-1-59745-559-6_5

Ruitenberg, Marc J., Hendriks, William T.J., Boer, Gerard J. and Verhaagen, Joost (2006). Gene Therapy for Spinal Cord Injury. Gene Therapy of the Central Nervous System: From Bench to Bedside. (pp. 273-288) Elsevier Inc.. doi: 10.1016/B978-012397632-1/50022-8

Hendriks, William T.J., Ruitenberg, Marc J., Blits, Bas, Boer, Gerard J. and Verhaagen, Joost (2004). Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. NGF and related molecules in health and disease. (pp. 451-476) edited by Aloe, Luigi and Calzà, Laura. Amsterdam , Netherlands: Elesevier. doi: 10.1016/S0079-6123(03)46029-9

Gillespie, Ellen R., Grice, Laura F., Courtney, Isabel G., Lao, Hong Wa, Jung, Woncheol, Ramkomuth, Sonny, Xie, Jacky, Brown, David A., Walsham, James, Radford, Kristen J., Nguyen, Quan H. and Ruitenberg, Marc J. (2024). Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems. Journal of Neuroinflammation, 21 (1) 63, 1-20. doi: 10.1186/s12974-024-03048-0

Ruitenberg, Marc J. and Nguyen, Quan H. (2024). Cellular neighborhood analysis in spatial omics reveals new tissue domains and cell subtypes. Nature Genetics, 56 (3), 362-364. doi: 10.1038/s41588-023-01646-x

Willis, Emily F., Kim, Seung Jae, Chen, Wei, Nyuydzefe, Melanie, MacDonald, Kelli P.A., Zanin-Zhorov, Alexandra, Ruitenberg, Marc J. and Vukovic, Jana (2024). ROCK2 regulates microglia proliferation and neuronal survival after traumatic brain injury. Brain, Behavior, and Immunity, 117, 181-194. doi: 10.1016/j.bbi.2024.01.004

Adams, Rachael C, Carter-Cusack, Dylan, Llanes, Genesis T, Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc J, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R, Furlan, Scott N, Zeiser, Robert and MacDonald, Kelli P.A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice. Blood Journal, 142 (Supplement 1), 2052-2052. doi: 10.1182/blood.2023022040

Pham, Duy, Tan, Xiao, Balderson, Brad, Xu, Jun, Grice, Laura F., Yoon, Sohye, Willis, Emily F., Tran, Minh, Lam, Pui Yeng, Raghubar, Arti, Kalita-de Croft, Priyakshi, Lakhani, Sunil, Vukovic, Jana, Ruitenberg, Marc J. and Nguyen, Quan H. (2023). Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues. Nature Communications, 14 (1) 7739, 1-25. doi: 10.1038/s41467-023-43120-6

Foster, Victoria, Saez, Natalie, Gillespie, Ellen, Jogia, Trisha, Reid, Chantelle, Maljevic, Snezana, Jung, Woncheol, Lao, Hong W., Ruitenberg, Marc Jan and King, Glen (2023). Genetic or pharmacological ablation of acid-sensing ion channel 1a (ASIC1a) is not neuroprotective in a mouse model of spinal cord injury. Journal of Neurotrauma. doi: 10.1089/neu.2022.0295

Willis, Emily F., Gillespie, Ellen R., Guse, Kirsten, Zuercher, Adrian W., Käsermann, Fabian, Ruitenberg, Marc J. and Vukovic, Jana (2023). Intravenous immunoglobulin (IVIG) promotes brain repair and improves cognitive outcomes after traumatic brain injury in a FcγRIIB receptor-dependent manner. Brain, Behavior, and Immunity, 109, 37-50. doi: 10.1016/j.bbi.2022.12.018

Shvetcov, Artur, Ruitenberg, Marc J., Delerue, Fabien, Gold, Wendy A., Brown, David A. and Finney, Caitlin A. (2023). The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury. Neuroscience and Biobehavioral Reviews, 146 105074, 1-18. doi: 10.1016/j.neubiorev.2023.105074

Alexander, Kylie A., Tseng, Hsu-Wen, Kulina, Irina, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Ruitenberg, Marc J. and Lévesque, Jean-Pierre (2022). Lymphocytes are not required for neurogenic heterotopic ossification development after spinal cord injury. Neurotrauma Reports, 3 (1), 87-96. doi: 10.1089/neur.2021.0072

Gillespie, Ellen R. and Ruitenberg, Marc J. (2022). Neuroinflammation after SCI: Current insights and therapeutic potential of intravenous immunoglobulin. Journal of Neurotrauma, 39 (3-4), 320-332. doi: 10.1089/neu.2019.6952

Jogia, Trisha, Kopp, Marcel A., Schwab, Jan M. and Ruitenberg, Marc J. (2021). Peripheral white blood cell responses as emerging biomarkers for patient stratification and prognosis in acute spinal cord injury. Current Opinion in Neurology, 34 (6), 796-803. doi: 10.1097/WCO.0000000000000995

Yates, Abi G., Jogia, Trisha, Gillespie, Ellen R., Couch, Yvonne, Ruitenberg, Marc J. and Anthony, Daniel C. (2021). Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury. Journal of Neuroinflammation, 18 (1) 15, 15. doi: 10.1186/s12974-020-02050-6

Harley, Samuel B. R., Willis, Emily F., Shaikh, Samreen N., Blackmore, Daniel G., Sah, Pankaj, Ruitenberg, Marc J., Bartlett, Perry F. and Vukovic, Jana (2021). Selective ablation of BDNF from microglia reveals novel roles in self-renewal and hippocampal neurogenesis. The Journal of Neuroscience, 41 (19), 4172-4186. doi: 10.1523/jneurosci.2539-20.2021

Debaud, Charlotte, Tseng, Hsu-Wen, Chedik, Malha, Kulina, Irina, Genêt, François, Ruitenberg, Marc J. and Levesque, Jean-Pierre (2021). Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal cord-injured mice in a lesion level-dependent manner. Journal of Neurotrauma, 38 (15) neu.2021.0058, 2162-2175. doi: 10.1089/neu.2021.0058

Jogia, Trisha, Lübstorf, Tom, Jacobson, Esther, Scriven, Elissa, Atresh, Sridhar, Nguyen, Quan H., Liebscher, Thomas, Schwab, Jan M., Kopp, Marcel A., Walsham, James, Campbell, Kate E. and Ruitenberg, Marc J. (2021). Prognostic value of early leukocyte fluctuations for recovery from traumatic spinal cord injury. Clinical and Translational Medicine, 11 (1) e272, e272. doi: 10.1002/ctm2.272

Wu, Mike C. L., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2020). Absence of the C5a receptor C5aR2 worsens ischemic tissue injury by increasing C5aR1-mediated neutrophil infiltration. The Journal of Immunology, 205 (10), 1-6. doi: 10.4049/jimmunol.2000778

Pham, Duy, Tan, Xiao, Xu, Jun, Grice, Laura F., Lam, Pui Yeng, Raghubar, Arti, Vukovic, Jana, Ruitenberg, Marc J. and Nguyen, Quan (2020). stLearn integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues. Biorxiv, 1-18. doi: 10.1101/2020.05.31.125658v1

Jogia, Trisha and Ruitenberg, Marc J. (2020). Traumatic spinal cord injury and the gut microbiota: current insights and future challenges. Frontiers in Immunology, 11 704, 704. doi: 10.3389/fimmu.2020.00704

Willis, Emily F., MacDonald, Kelli P. A., Nguyen, Quan H., Garrido, Adahir Labrador, Gillespie, Ellen R., Harley, Samuel B. R., Bartlett, Perry F., Schroder, Wayne A., Yates, Abi G., Anthony, Daniel C., Rose-John, Stefan, Ruitenberg, Marc J. and Vukovic, Jana (2020). Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner. Cell, 180 (5), 833-846.e16. doi: 10.1016/j.cell.2020.02.013

McGill, Raquel B., Steyn, Frederik J., Ngo, Shyuan T., Thorpe, Kathryn A., Heggie, Susan, Ruitenberg, Marc J., Henderson, Robert D., McCombe, Pamela A. and Woodruff, Trent M. (2020). Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis. Brain Communications, 2 (1) fcaa013, fcaa013. doi: 10.1093/braincomms/fcaa013

Matuzelski, Elise, Harvey, Tracey J., Harkins, Danyon, Nguyen, Thuan, Ruitenberg, Marc J. and Piper, Michael (2020). Expression of NFIA and NFIB within the murine spinal cord. Gene Expression Patterns, 35 119098, 119098. doi: 10.1016/j.gep.2020.119098

Yates, Abi G., Anthony, Daniel C., Ruitenberg, Marc J. and Couch, Yvonne (2019). Systemic immune response to traumatic CNS injuries-are extracellular vesicles the missing link?. Frontiers in Immunology, 10 2723, 2723. doi: 10.3389/fimmu.2019.02723

Golakani, Masoud Hassanpour, Mohammad, Mohammad G., Li, Hui, Gamble, Joanne, Breit, Samuel N., Ruitenberg, Marc J. and Brown, David A. (2019). MIC-1/GDF15 overexpression is associated with increased functional recovery in traumatic spinal cord injury. Journal of Neurotrauma, 36 (24) neu.2019.6421, 3410-3421. doi: 10.1089/neu.2019.6421

Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019). p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 (40), 7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019

Brennan, Faith H., Jogia, Trisha, Gillespie, Ellen R., Blomster, Linda V., Li, Xaria X., Nowlan, Bianca, Williams, Gail M., Jacobson, Esther, Osborne, Geoff W., Meunier, Frederic A., Taylor, Stephen M., Campbell, Kate E., MacDonald, Kelli P.A., Levesque, Jean-Pierre, Woodruff, Trent M. and Ruitenberg, Marc J. (2019). Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight, 4 (9) e98254. doi: 10.1172/jci.insight.98254

Hazleton, Isla, Yates, Abi, Dale, Ashley, Roodselaar, Jay, Akbar, Naveed, Ruitenberg, Marc, Anthony, Daniel C. and Couch, Yvonne (2018). Exacerbation of acute traumatic brain injury by circulating extracellular vesicles. Journal of Neurotrauma, 35 (4), 639-651. doi: 10.1089/neu.2017.5049

Ruitenberg, Marc J., Wells, Julia, Bartlett, Perry F., Harvey, Alan R. and Vukovic, Jana (2017). Enrichment increases hippocampal neurogenesis independent of blood monocyte-derived microglia presence following high-dose total body irradiation. Brain Research Bulletin, 132, 150-159. doi: 10.1016/j.brainresbull.2017.05.013

Biggins, Patrick, Brennan, Faith, Taylor, Stephen, Woodruff, Trent and Ruitenberg, Marc (2017). The alternative receptor for complement component 5a, C5aR2, conveys neuroprotection in traumatic spinal cord injury. Journal of Neurotrauma, 34 (12), 2075-2085. doi: 10.1089/neu.2016.4701

Lee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730

Chen, Min, Arumugam, Thiruma V., Leanage, Gayeshika, Tieng, Quang M., Yadav, Ashwin, Ullmann, Jeremy F. P., She, David T., Truong, Vy, Ruitenberg, Marc J. and Reutens, David C. (2017). Disease-modifying effect of intravenous immunoglobulin in an experimental model of epilepsy. Scientific Reports, 7 (1) 40528, 40528. doi: 10.1038/srep40528

Jung, Won-Cheol, Levesque, Jean-Pierre and Ruitenberg, Marc J. (2017). It takes nerve to fight back: the significance of neural innervation of the bone marrow and spleen for immune function. Seminars in Cell and Developmental Biology, 61, 60-70. doi: 10.1016/j.semcdb.2016.08.010

Arumugam, Thiruma V., Manzanero, Silvia, Furtado, Milena, Biggins, Patrick J., Hsieh, Yu Hsuan, Gelderblom, Mathias, MacDonald, Kelli P. A., Salimova, Ekaterina, Li, Yu I., Korn, Othmar, Dewar, Deborah, Macrae, I. Mhairi, Ashman, Robert B., Tang, Sung-Chun, Rosenthal, Nadia A., Ruitenberg, Marc J., Magnus, Tim and Wells, Christine A. (2016). An atypical role for the myeloid receptor Mincle in central nervous system injury. Journal of Cerebral Blood Flow and Metabolism, 37 (6), 2098-2111. doi: 10.1177/0271678X16661201

Dando, Samantha J., Naranjo Golborne, Cecilia, Chinnery, Holly R., Ruitenberg, Marc J. and McMenamin, Paul G. (2016). A case of mistaken identity: CD11c-eYFP+ cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells. Glia, 64 (8), 1331-1349. doi: 10.1002/glia.23005

Brennan, Faith H., Kurniawan, Nyoman D., Vukovic, Jana, Bartlett, Perry F., Käsermann, Fabian, Arumugam, Thiruman V., Basta, Milan and Ruitenberg, Marc J. (2016). IVIg attenuates complement and improves spinal cord injury outcomes in mice. Annals of Clinical and Translational Neurology, 3 (7), 495-511. doi: 10.1002/acn3.318

Brennan, Faith H., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2016). Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions. Seminars in Immunology, 28 (3), 292-308. doi: 10.1016/j.smim.2016.03.015

Brennan, Faith H. and Ruitenberg, Marc J. (2015). Targeting acute inflammation to complement spinal cord repair. Neural Regeneration Research, 10 (10), 1596-1598. doi: 10.4103/1673-5374.165268

Brennan, Faith H., Gordon, Richard, Lao, Hong W., Biggins, Patrick J., Taylor, Stephen M., Franklin, Robin J. M., Woodruff, Trent M. and Ruitenberg, Marc J. (2015). The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injury. Journal of Neuroscience, 35 (16), 6517-6531. doi: 10.1523/JNEUROSCI.5218-14.2015

Low, Pei Ching, Manzanero, Silvia, Mohannak, Nika, Narayana, Vinod K., Nguyen, Tam H., Kvaskoff, David, Brennan, Faith H., Ruitenberg, Marc J., Gelderblom, Mathias, Magnus, Tim, Kim, Hyun Ah, Broughton, Brad R. S., Sobey, Christopher G., Vanhaesebroeck, Bart, Stow, Jennifer L., Arumugam, Thiruma V. and Meunier, Frédéric A. (2014). PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. Nature Communications, 5 (3450) 3450, 1-12. doi: 10.1038/ncomms4450

Mohammad, Mohammad G., Tsai, Vicky W.W., Ruitenberg, Marc J., Hassanpour, Masoud, Li, Hui, Hart, Prue H., Breit, Samuel N., Sawchenko, Paul E. and Brown, David A. (2014). Immune cell trafficking from the brain maintains CNS immune tolerance. Journal of Clinical Investigation, 124 (3), 1228-1241. doi: 10.1172/JCI71544

Brennan, Faith H., Cowin, Gary J., Kurniawan, Nyoman D. and Ruitenberg, Marc J. (2013). Longitudinal assessment of white matter pathology in the injured mouse spinal cord through ultra-high field (16.4T) in vivo diffusion tensor imaging. NeuroImage, 82, 574-585. doi: 10.1016/j.neuroimage.2013.06.019

Blomster, Linda V., Brennan, Faith H., Lao, Hong W., Harle, David W., Harvey, Alan R. and Ruitenberg, Marc J. (2013). Mobilisation of the splenic monocyte reservoir and peripheral CX(3)CR1 deficiency adversely affects recovery from spinal cord injury. Experimental Neurology, 247, 226-240. doi: 10.1016/j.expneurol.2013.05.002

Wu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M. and Woodruff, Trent M. (2013). The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America, 110 (23), 9439-9444. doi: 10.1073/pnas.1218815110

Vukovic, Jana, Borlikova, Gilyana G., Ruitenberg, Marc J., Robinson, Gregory J., Sullivan, Robert K. P., Walker, Tara L. and Bartlett, Perry F. (2013). Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering. Journal of Neuroscience, 33 (15), 6603-6613. doi: 10.1523/JNEUROSCI.3064-12.2013

Spanevello, Mark Damien, Tajouri, Sophie Ines, Mirciov, Cornel, Kurniawan, Nyoman, Pearse, Martin John, Fabri, Louis Jerry, Owczarek, Catherine Mary, Hardy, Matthew Philip, Bradford, Rebecca Anne, Ramunno, Melanie Louise, Turnley, Ann Maree, Ruitenberg, Marc Jan, Boyd, Andrew Wallace and Bartlett, Perry Francis (2013). Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats. Journal of Neurotrauma, 30 (12), 1023-1034. doi: 10.1089/neu.2012.2729

Harrison, Megan, O'Brien, Aine, Adams, Lucy, Cowin, Gary, Ruitenberg, Marc J., Sengul, Gulgun and Watson, Charles (2013). Vertebral landmarks for the identification of spinal cord segments in the mouse. NeuroImage, 68, 22-29. doi: 10.1016/j.neuroimage.2012.11.048

Blomster, Linda V., Cowin, Gary J., Kurniawan, Nyoman D. and Ruitenberg, Marc J. (2013). Detection of endogenous iron deposits in the injured mouse spinal cord through high-resolution ex vivo and in vivo MRI. NMR in Biomedicine, 26 (2), 141-150. doi: 10.1002/nbm.2829

Schmid, Annina B., Coppieters, Michel W., Ruitenberg, Marc J. and McLachlan, Elspeth M. (2013). Local and remote immune-mediated inflammation after mild peripheral nerve compression in rats. Journal of Neuropathology and Experimental Neurology, 72 (7), 662-680. doi: 10.1097/NEN.0b013e318298de5b

Mohammad, G. Mohammad, Hassanpour, Masoud, Tsai, Vicky W. W., Li, Hui, Ruitenberg, Marc J., Booth, David R., Serrats, Jordi, Hart, Prue H., Symonds, Geoffrey P., Sawchenko, Paul E., Breit, Samuel N. and Brown, David A. (2013). Dendritic cells and multiple sclerosis: disease, tolerance and therapy. International Journal of Molecular Sciences, 14 (1), 547-562. doi: 10.3390/ijms14010547

Chinnery, Holly R., McLenachan, Samuel, Humphries, Timothy, Kezic, Jelena M., Chen, Xiangting, Ruitenberg, Marc J. and McMenamin, Paul G. (2012). Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX(3)CR1. Neurobiology of Aging, 33 (8), 1769-1776. doi: 10.1016/j.neurobiolaging.2011.03.010

Etemad, Samar, Zamin, Rasheeda Mohd, Ruitenberg, Marc J. and Filgueira, Luis (2012). A novel in vitro human microglia model: Characterization of human monocyte-derived microglia. Journal of Neuroscience Methods, 209 (1), 79-89. doi: 10.1016/j.jneumeth.2012.05.025

Brennan, Faith H., Anderson, Aileen J., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012). Complement activation in the injured central nervous system: Another dual-edged sword?. Journal of Neuroinflammation, 9 (1) 137, 137. doi: 10.1186/1742-2094-9-137

Vukovic, Jana, Colditz, Michael J., Blackmore, Daniel G., Ruitenberg, Marc J. and Bartlett, Perry F. (2012). Microglia modulate hippocampal neural precursor activity in response to exercise and aging. Journal of Neuroscience, 32 (19), 6435-6443. doi: 10.1523/JNEUROSCI.5925-11.2012

Rupasinghe, Darshani B., Knapp, Oliver, Blomster, Linda V., Schmid, Annina B., Adams, David J., King, Glenn F. and Ruitenberg, Marc J. (2012). Localization of Na(v)1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function. Channels, 6 (2), 103-110. doi: 10.4161/chan.19484

Blomster, Linda, Vukovic, Jana, Hendrickx, Debbie A.E., Jung, Steffen, Harvey, Alan R., Filgueira, Luis and Ruitenberg, Marc J. (2011). CX(3)CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium. Molecular and Cellular Neuroscience, 48 (3), 236-245. doi: 10.1016/j.mcn.2011.08.004

Belavy, David, Ruitenberg, Marc and Brijball, Rajesh (2011). Feasibility study of real-time three-/four-dimensional ultrasound for epidural catheter insertion. British Journal of Anaesthesia, 107 (3), 438-445. doi: 10.1093/bja/aer157

Roet, Kasper C.D., Bossersa, Koen, Franssen, Elske H.P., Ruitenberg, Marc J. and Verhaagen, Joost (2011). A meta-analysis of microarray-based gene expression studies of olfactory bulb-derived olfactory ensheathing cells. Experimental Neurology, 229 (1), 10-45. doi: 10.1016/j.expneurol.2011.03.001

Vukovic, J, Blomster, LV, Chinnery, HR, Weninger, W, Jung, S, McMenamin, PG and Ruitenberg, MJ (2010). Bone marrow chimeric mice reveal a role for CX3CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium. Journal of Leukocyte Biology, 88 (4), 645-654. doi: 10.1189/jlb.0410194

Chinnery, Holly R., Ruitenberg, Marc J. and McMenamin, Paul G. (2010). Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice. Journal of Neuropathology and Experimental Neurology, 69 (9), 896-909. doi: 10.1097/NEN.0b013e3181edbc1a

Vukovic, Jana, Marmorstein, Lihua Y., McLaughlin, Precious J., Sasaki, Takako, Plant, Giles W., Harvey, Alan R. and Ruitenberg, Marc J. (2009). Lack of fibulin-3 alters regenerative tissue responses in the primary olfactory pathway. Matrix Biology, 28 (7), 406-415. doi: 10.1016/j.matbio.2009.06.001

Hellstrom, M., Ruitenberg, M. J., Pollett, M. A., Ehlert, E. M. E., Twisk, J., Verhaagen, J. and Harvey, A. R. (2009). Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection. Gene Therapy, 16 (4), 521-532. doi: 10.1038/gt.2008.178

Vukovic, Jana, Ruitenberg, Marc J., Roet, Kasper, Franssen, Elske, Arulpragasam, Ajanthy, Sasaki, Takako, Verhaagen, Joost, Harvey, Alan R., Busfield, Samantha J. and Plant, Giles W. (2009). The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro. Glia, 57 (4), 424-443. doi: 10.1002/glia.20771

Ruitenberg, Marc J., Vukovic, Jana, Blomster, Linda, Hall, Jarrad M, Jung, Steffen, Filgueira, Luis, McMenamin, Paul G. and Plant, Giles W. (2008). CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium. Journal of Neuroimmunology, 205 (1-2), 80-85. doi: 10.1016/j.jneuroim.2008.09.010

Ruitenberg, Marc J. and Vukovic, Jana (2008). Promoting central nervous system regeneration: Lessons from cranial nerve I. Restorative Neurology and Neuroscience, 26 (2-3), 183-196.

Vukovic, Jana, Plant, Giles W., Ruitenberg, Marc J. and Harvey, Alan R. (2007). Influence of adult Schwann cells and olfactory ensheathing glia on axontarget cell interactions in the CNS a comparative analysis using a retinotectal cograft model. Neuron Glia Biology, 3 (2), 105-117. doi: 10.1017/S1740925X07000671

Chinnery, Holly R., Ruitenberg, Marc J., Plant, Giles W., Pearlman, Eric, Jung, Steffen and McMenamin, Paul G. (2007). The chemokine receptor CX3CR1 mediates homing of MHC class II-positive cells to the normal mouse corneal epithelium. Investigative Ophthalmology and Visual Science, 48 (4), 1568-1574. doi: 10.1167/iovs.06-0746

Ruitenberg, Marc J., Vukovic, Jana, Sarich, Julijana, Busfield, Samantha J. and Plant, Giles W. (2006). Olfactory ensheathing cells: Characteristics, genetic engineering, and therapeutic potential. Journal of Neurotrauma, 23 (3-4), 468-478. doi: 10.1089/neu.2006.23.468

Hendriks, William T.J., Eggers, Ruben, Ruitenberg, Marc J., Blits, Bas, Hamers, Frank P.T., Verhaagen, Joost and Boer, Gerard J. (2006). Profound differences in spontaneous long-term functional recovery after defined spinal tract lesions in the rat. Journal of Neurotrauma, 23 (1), 18-35. doi: 10.1089/neu.2006.23.18

Ruitenberg, Marc J., Levison, Dane B., Lee, Seok Voon, Verhaagen, Joost, Harvey, Alan R. and Plant, Giles W. (2005). NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration. Brain, 128 (4), 839-853. doi: 10.1093/brain/awh424

Blits, Bas, Carlstedt, Thomas P., Ruitenberg, Marc Jan, de Winter, Fred, Hermens, Wim T. J. M. C., Dijkhuizen, Paul A., Claasens, Jill W. C., Eggers, Ruben, van der Sluis, Ronald, Tenenbaum, Liliane, Boer, Gerard J. and Verhaagen, Joost (2004). Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor. Experimental Neurology, 189 (2), 303-316. doi: 10.1016/j.expneurol.2004.05.014

Ruitenberg, Mark J., Blits, Bas, Dijkhuizen, Paul A., te Beek, Eric T., Bakker, Arne, van Heerikhuize, Joop J., Pool, Chris W., Hermens, Wim T. J., Boer, Gerard J. and Verhaagen, Joost (2004). Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury. Neurobiology of Disease, 15 (2), 394-406. doi: 10.1016/j.nbd.2003.11.018

Ruitenberg, Marc J., Plant, Giles W., Hamers, Frank P.T., Wortel, Joke, Blits, Bas, Dijkhuizen, Paul A., Gispen, Willem Hendrik, Boer, Gerard J. and Verhaagen, Joost (2003). Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: Effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord. The Journal of Neuroscience, 23 (18), 7045-7058.

Eaton, M. J., Blits, B., Ruitenberg, M. J., Verhaagen, J. and Oudega, M. (2002). Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord. Gene Therapy, 9 (20), 1387-1395. doi: 10.1038/sj.gt.3301814

Ruitenberg, M. J., Eggers, R., Boer, G. J. and Verhaagen, J. (2002). Adeno-associated viral vectors as agents for gene delivery: Application in disorders and trauma of the central nervous system. Methods, 28 (2), 182-194. doi: 10.1016/S1046-2023(02)00222-0

De Winter, F, Oudega, M., Lankhorst, A. J., Hamers, F. P., Blits, B., Ruitenberg, M. J., Pasterkamp, R. J., Gispen, W. H. and Verhaagen, J. (2002). Injury-induced class 3 semaphorin expression in the rat spinal cord. Experimental Neurology, 175 (1), 61-75. doi: 10.1006/exnr.2002.7884

Ruitenberg, M. J., Plant, G. W., Christensen, C. L., Blits, B., Niclou, S. P., Harvey, AR, Boer, G. J. and Verhaagen, J. (2002). Viral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cord. Gene Therapy, 9 (2), 135-146. doi: 10.1038/sj/gt/3301626

Pasterkamp, R. J., Ruitenberg, M. J. and Verhaagen, J. (1999). Semaphorins and their receptors in olfactory axon guidance. Cellular and Molecular Biology, 45 (6), 763-769.

Pasterkamp, R. J., Ruitenberg, M. J. and Verhaagen, J. (1999). Semaphorins and their receptors in olfactory axon guidance. Cellular and Molecular Biology, 45 (6), 763-79.

Pasterkamp, R. J., Giger, R. J., Ruitenberg, M. J., Holtmaat, A. J., De Wit, J., De Winter, F. and Verhaagen, J. (1999). Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS. Molecular and Cellular Neurosciences, 13 (2), 143-166. doi: 10.1006/mcne.1999.0738

Adams, Rachael C., Carter-Cusack, Dylan, Llanes, Genesis T., Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R., Furlan, Scott N., Zeiser, Robert and MacDonald, Kelli P. A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice. 65th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, United States, 9-12 December 2023. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2023-184841

Vo, Tuan, Balderson, Brad, Jones, Kahli, Crawford, Joanna, Millar, Amanda, Tolson, Elissa, Ruitenberg, Marc, Robertson, Thomas, Bhuva, Dharmesh, Davis, Melissa, Wainwright, Brandon, Nguyen, Quan and Genovesi, Laura (2022). MEDB-06. Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that loss of heterogeneity and induced differentiation underlies the response to CDK4/6 inhibition. International Symposium on Pediatric Neuro-Oncology, Hamburg, Germany, 12–15 June 2022. Cary, NC, United States: Oxford University Press. doi: 10.1093/neuonc/noac079.381

Jung, Won-Cheol, Jogia, Trisha, Gillespie, Ellen, Reid, Chantelle, Levesque, Jean-Pierre and Ruitenberg, Marc (2018). Understanding hematopoietic stem/progenitor cell responses after spinal cord injury. 3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, Toronto, Canada, 11-16 August 2018. New Rochelle, NY, United States: Mary Ann Liebert.

Dando, Samantha, Naranjo-Golborne, Cecilia, Chinnery, Holly, Ruitenberg, Marc and McMenamin, Paul G. (2016). The rd8 mutation in the Crumbs1 gene upregulates activation markers on retinal and brain microglia and CD11c-eYFP(+) cells. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Seattle, WA USA, May 01-05, 2016. Rockville, MD USA: Association for Research in Vision and Ophthalmology.

Biggins, P. J. C., Brennan, F. H., Taylor, S. M., Woodruff, T. M. and Ruitenberg, M. J. (2016). Investigating the role of complement component C5a receptor 2 (C5aR2/C5L2) in spinal cord injury. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.058

Dando, S., Chinnery, H., Ruitenberg, M. and McMenamin, P. (2016). Immune privilege in the central nervous system revisited: are there dendritic cells in the brain?. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August, 2016. Weinheim, Germany: Wiley.

Golakani, Hassanpour M., Mohammad, M., Li, H., Saxena, M., Breit, S., Ruitenberg, M. and Brown, D. (2016). Dynamics of inflammatory immune response in a mouse model of traumatic spinal cord injury, potential therapeutic targets. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. Germany: Wiley.

Dando, Samantha, Chen, Xiangting, Ruitenberg, Marc and McMenamin, Paul G. (2015). Characterization of YFP plus cells in the retina of CD11c-eYFP transgenic mice: the effects of breeding out the Crb1(rd8) mutation. Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Denver, CO United States, May 3-7, 2015. Rockville, MD United States: Association for Research in Vision and Ophthalmology.

Mohammad, Mohammad, Tsai, Vicky Wang Wei, Ruitenberg, Marc, Hassanpour, Masoud, Li, Hui, Hart, Prue, Breit, Samuel, Sawchenko, Paul and Brown, David (2014). CNS DCs modulate peripheral anti-CNS immunity. 12th International Congress of Neuroimmunology (ISNI), Mainz Germany, 9-13 November, 2014. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.jneuroim.2014.08.218

Ruitenberg, Marc J., Brennan, Faith H., Gordon, Richard, Blomster, Linda V., Lao, Hong Wa, Cowin, Gary J., Taylor, Stephen M. and Woodruff, Trent M. (2014). Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord Injury. 11th Symposium of the International-Neurotrauma-Society, Budapest, Hungary, 19-23 March 2014. New Rochelle, NY United States: Mary Ann Liebert.

Low, Pei Ching (Regine), Manzanero, Silvia, Narayana, Vinod K., Nguyen, Tam H., Kvaskoff, David, Brennan, Faith H., Ruitenberg, Marc J., Gelderblom, Mathias, Magnus, Tim, Kim, Hyun Ah, Broughton, Brad R. S., Sobey, Christopher G., Vanhaesebroeck, Bart, Stow, Jennifer L., Arumugam, Thiruma V. and Meunier, Frederic A. (2014). PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, Australia, 26-29 October 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.126

Filgueira, L., Etemad, S. and Ruitenberg, M. (2013). A Novel Human in Vitro Microglia Model. 11th European Meeting on Glial Cell Function in Health and Disease, Berlin, Germany, 03-06 July 2013. Hoboken, NJ United States: John Wiley and Sons Inc.. doi: 10.1002/glia.22530

Etemad, Samar, Ruitenberg, Marc and Filgueira, Luis (2012). In vitro generated microglia derived from blood precursors. Experimental Biology Meeting, San Diego Ca, 21-25 April 2012. Bethesda, MD, United States: Federation of American Societies for Experimental Biology.

Brennan, Faith H., Blomster, Linda V., Costantini, Alexander M., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012). Deficiency of the complement anaphylatoxin receptor C3aR on leukocytes worsens the outcome from spinal cord injury by promoting neutrophilia. 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, 4-8 November 2012. Amsterdam, The Netherlands: Elsevier.

Woodruff, Trent M., Wu, Mike C. L., Brennan, Faith H., Wetsel, Rick A., Ruitenberg, Marc J. and Taylor, Stephen M. (2012). The C3a receptor mediates protection from intestinal ischemia reperfusion injuries by impairing neutrophil mobilization. 24th International Complement Workshop (ICW), Chania, Crete, Greece, 10-15 October 2012. Jena, Germany: Urban und Fischer Verlag. doi: 10.1016/j.imbio.2012.08.229

Etemad, Samar, Ruitenberg, Marc and Filgueira, Luis (2012). In vitro generated human microglia derived from blood precursors. 99th Annual Meeting of the American Association of Immunologists, Boston, MA, United States, 4 -8 May 2012. Bethesda, MD, United States: American Association of Immunologists.

Harris, J, Ruitenberg, M, West, A and Chuah, M (2010). IMMUNE RESPONSES TO BACTERIAL CHALLENGE IN OLFACTORY TISSUES OF CX3CR1(+/GFP) AND CX3CR1(GFP/GFP) MICE. 10th Biennial Meeting of the Asia-Pacific Society of Neurochemistry, Phuket, Thailand, 18-20 October 2010.

Hendriks, WTJ, Ruitenberg, MJ, Blits, B, Boer, GJ and Verhaagen, J (2004). Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. 7th International Conference on NGF and Related Molecules, Modena Italy, May 15-19, 2002. AMSTERDAM: ELSEVIER SCIENCE BV.

Ruitenberg, M. J., Plant, G. W., Blits, B., Christensen, C. L., Boer, G. J. and Verhaagen, J. (2001). Genetically engineered olfactory ensheathing glia implants in the lesioned cervical rat spinal cord. European Society for Neurochemistry meeting, Perugia, Italy, 2001. OXFORD: BLACKWELL SCIENCE LTD.

Professor Marc Ruitenberg

PhD and MPhil Supervision

Publications

Book Chapters

Journal Articles

Conference Papers