Professor Rod Minchin heads the molecular and cellular pharmacology lab.
PhD and MPhil Supervision
- View current and completed supervisions on UQ Researchers.
Find out more information on how to apply for a Research Higher Degree (MPhil or PhD) with the School. For all enquiries regarding research supervision, please contact ask@uq.edu.au.
Book Chapters
Butcher, Neville J., Li, Pengcheng, Wang, Lili and Minchin, Rodney F. (2018). Human Arylamine N-Acetyltransferase Type 1. Arylamine N-acetyltransferases in Health and Disease: From Pharmacogenetics to Drug Discovery and Diagnostics. (pp. 91-107) edited by Nicola Laurieri and Edith Sim. Singapore: World Scientific Publishing. doi: 10.1142/9789813232013_0004
Mortimer, G. M. and Minchin, R. F. (2017). Nanotoxicology and nanovaccines. Micro- and nanotechnology in vaccine development . (pp. 373-392) edited by Mariusz Skwarczynski and Istvan Toth. Oxford, United Kingdom: William Andrew / Elsevier . doi: 10.1016/B978-0-323-39981-4.00020-8
Martin, D., Minchin, R. F., Belkina, M., Milev, A. and Kannangara, G. S. Kamali (2011). Toxicity and regulatory perspectives of carbon nanotubes. Polymer-carbon nanotube composites : Preparation, properties and applications. (pp. 621-653) edited by Tony McNally and Petra Pötschke. Cambridge, U.K.: Woodhead Publishing. doi: 10.1533/9780857091390.2.621
Butcher, Neville J. and Minchin, Rodney F. (2008). Arylamine N-Acetyltransferases. Encyclopedia of cancer. (pp. 255-257) edited by Manfred Schwab. Berlin, Germany: Springer Verlag. doi: 10.1007/978-3-540-47648-1_408
Butcher, N. J. and Minchin, R. F. (2005). Arylamine N-Acetyltransferase Gene Polymorphism. Encyclopedia of Medical Genomics and Proteomics. (pp. 79-83) edited by Jurgen Fuchs and Maurizio Podda. New York: Marcel Dekker.
Journal Articles
Choudhury, Chandra, Egleton, James E., Butcher, Neville J., Russell, Angela J. and Minchin, Rodney F. (2024). Small Molecule Inhibitors of Arylamine N-Acetyltransferase 1 Attenuate Cellular Respiration. ACS Pharmacology & Translational Science, 7 (8), 2326-2332. doi: 10.1021/acsptsci.4c00282
Subasic, Christopher N., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2024). A PEGylated liposomal formulation of prochlorperazine that limits brain exposure but retains dynamin II activity: A potential adjuvant therapy for cancer patients receiving chemotherapeutic mAbs. Nanomedicine: Nanotechnology, Biology and Medicine, 56 102733, 1-8. doi: 10.1016/j.nano.2024.102733
Choudhury, Chandra, Gill, Melinder K., McAleese, Courtney E., Butcher, Neville J., Ngo, Shyuan T., Steyn, Frederik J. and Minchin, Rodney F. (2023). The arylamine N-acetyltransferases as therapeutic targets in metabolic diseases associated with mitochondrial dysfunction. Pharmacological Reviews, 76 (2), 300-320. doi: 10.1124/pharmrev.123.000835
Subasic, Christopher N., Butcher, Neville J., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2023). Dose-dependent effect of phenothiazines as dynamin II inhibitors on the uptake of PEGylated liposomes by endocytic cells and in vivo pharmacokinetics of PEGylated liposomal doxorubicin in rats. Molecular Pharmaceutics, 20 (9), 4468-4477. doi: 10.1021/acs.molpharmaceut.3c00102
Choudhury, Chandra, McAleese, Courtney E., Butcher, Neville J. and Minchin, Rodney F. (2023). Contrasting effects of temperature on human arylamine N-acetyltransferase and acetyl coenzyme A hydrolase activities. Biochemistry, 62 (14), 2093-2097. doi: 10.1021/acs.biochem.3c00113
Subasic, Christopher N., Butcher, Neville J., Minchin, Rodney F. and Kaminskas, Lisa M. (2023). Dose-dependent production of anti-PEG IgM after intramuscular PEGylated-hydrogenated soy phosphatidylcholine liposomes, but not lipid nanoparticle formulations of DNA, correlates with the plasma clearance of PEGylated liposomal doxorubicin in rats. Molecular Pharmaceutics, 20 (7), 3494-3504. doi: 10.1021/acs.molpharmaceut.3c00104
McAleese, Courtney E., Butcher, Neville J. and Minchin, Rodney F. (2022). Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis. Breast Cancer Research and Treatment, 195 (3), 223-236. doi: 10.1007/s10549-022-06668-3
Choudhury, Chandra, Butcher, Neville J. and Minchin, Rodney F. (2022). Polymorphism in the human arylamine N-acetyltransferase 1 gene 3′-untranslated region determines polyadenylation signal usage. Biochemical Pharmacology, 200 115020, 115020. doi: 10.1016/j.bcp.2022.115020
Subasic, Christopher N., Kuilamu, Esther, Cowin, Gary, Minchin, Rodney F. and Kaminskas, Lisa M. (2021). The pharmacokinetics of PEGylated liposomal doxorubicin are not significantly affected by sex in rats or humans, but may be affected by immune dysfunction. Journal of Controlled Release, 337, 71-80. doi: 10.1016/j.jconrel.2021.07.006
Payne, Colton D., Franke, Bastian, Fisher, Mark F., Hajiaghaalipour, Fatemeh, McAleese, Courtney E., Song, Angela, Eliasson, Carl, Zhang, Jingjing, Jayasena, Achala S., Vadlamani, Grishma, Clark, Richard J., Minchin, Rodney F., Mylne, Joshua S. and Rosengren, K. Johan (2021). A chameleonic macrocyclic peptide with drug delivery applications. Chemical Science, 12 (19), 6670-6683. doi: 10.1039/d1sc00692d
McAleese, Courtney E., Choudhury, Chandra, Butcher, Neville J. and Minchin, Rodney F. (2021). Hypoxia-mediated drug resistance in breast cancers. Cancer Letters, 502, 189-199. doi: 10.1016/j.canlet.2020.11.045
Wang, Lili, Butcher, Neville J, Minchin, Rodney F and Kaminskas, Lisa M (2021). Monocytes do not contribute to sex differences seen in the pharmacokinetics of pegylated liposomal doxorubicin. Journal of Pharmaceutical Sciences, 110 (8), 3099-3101. doi: 10.1016/j.xphs.2021.05.009
Kuilamu, Esther, Subasic, Christopher, Cowin, Gary J., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2020). Cetuximab exhibits sex differences in lymphatic exposure after intravenous administration in rats in the absence of differences in plasma exposure. Pharmaceutical Research, 37 (11) 224, 1-12. doi: 10.1007/s11095-020-02945-2
Butcher, Neville J., Burow, Rachel and Minchin, Rodney F. (2020). Modulation of human arylamine N-acetyltransferase 1 activity by lysine acetylation: role of p300/CREB-binding protein and sirtuins 1 and 2. Molecular Pharmacology, 98 (2), 88-95. doi: 10.1124/mol.119.119008
Idris, Misgana, Mitchell, Deanne J., Gordon, Richard, Sidharthan, Neelima P., Butcher, Neville J. and Minchin, Rodney F. (2020). Interaction of the brain-selective sulfotransferase SULT4A1 with other cytosolic sulfotransferases: effects on protein expression and function. Drug Metabolism and Disposition, 48 (5), 337-344. doi: 10.1124/dmd.119.089714
Li, Pengcheng, Butcher, Neville J. and Minchin, Rodney F. (2020). Effect arylamine N-acetyltransferase 1 on morphology, adhesion, migration, and invasion of MDA-MB-231 cells: role of matrix metalloproteinases and integrin αV. Cell Adhesion and Migration, 14 (1), 1-11. doi: 10.1080/19336918.2019.1710015
Li, Pengcheng, Butcher, Neville J. and Minchin, Rod (2019). Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-α. Molecular Pharmacology, 96 (5), 573-579. doi: 10.1124/mol.119.117432
Wang, Lili, Subasic, Christopher, Minchin, Rodney F. and Kaminskas, Lisa M. (2019). Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastases. Nanomedicine, 14 (12), 1605-1621. doi: 10.2217/nnm-2018-0478
Wang, Lili, Minchin, Rodney F., Essebier, Patricia J. and Butcher, Neville J. (2019). Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex. International Journal of Biochemistry and Cell Biology, 110, 84-90. doi: 10.1016/j.biocel.2019.03.002
Idris, Misgana, Butcher, Neville J and Minchin, Rodney F (2019). The MBNL/CELF splicing factors regulate cytosolic sulfotransferase 4A1 protein expression during cell differentiation. Drug Metabolism and Disposition, 47 (3), 314-319. doi: 10.1124/dmd.118.085290
Minchin, Rodney F., Rosengren, K. Johan, Burow, Rachel and Butcher, Neville J. (2018). Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate. Biochemical Pharmacology, 158, 153-160. doi: 10.1016/j.bcp.2018.10.013
Minchin, Rodney F. and Butcher, Neville J. (2018). Trimodal distribution of arylamine N-acetyltransferase 1 mRNA in breast cancer tumors: association with overall survival and drug resistance. BMC Genomics, 19 (1) 513, 513. doi: 10.1186/s12864-018-4894-4
Wang, LiLi, Minchin, Rodney F and Butcher, Neville J (2018). Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability. PLoS One, 13 (3) e0193560, e0193560. doi: 10.1371/journal.pone.0193560
Butcher, N. J., Horne, M. K., Mellick, G. D., Fowler, C. J., Masters, C. L. and Minchin, R. F. (2017). Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease. Pharmacogenomics Journal, 18 (2), 209-214. doi: 10.1038/tpj.2017.4
Witham, Katey L., Minchin, Rodney F. and Butcher, Neville J. (2017). Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway. Biochemical Pharmacology, 125, 93-100. doi: 10.1016/j.bcp.2016.11.015
Mortimer, Gysell M. and Minchin, Rodney F. (2016). Cryptic epitopes and functional diversity in extracellular proteins. International Journal of Biochemistry and Cell Biology, 81 (Part A), 112-120. doi: 10.1016/j.biocel.2016.10.020
Zhang, Jing, Woodruff, Trent M., Clark, Richard J., Martin, Darren J. and Minchin, Rodney F. (2016). Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition. Acta Biomaterialia, 41, 264-272. doi: 10.1016/j.actbio.2016.05.034
Shaw, Catherine A., Mortimer, Gysell M., Deng, Zhou J., Carter, Edwin S., Connell, Shea P., Miller, Mark R., Duffin, Rodger, Newby, David E., Hadoke, Patrick W. F. and Minchin, Rodney F. (2016). Protein corona formation in bronchoalveolar fluid enhances diesel exhaust nanoparticle uptake and pro-inflammatory responses in macrophages. Nanotoxicology, 10 (7), 981-991. doi: 10.3109/17435390.2016.1155672
Mortimer, Gysell M., Jack, Kevin S., Musumeci, Anthony W., Martin, Darren J. and Minchin, Rodney F. (2016). Stable non-covalent labeling of layered silicate nanoparticles for biological imaging. Materials Science and Engineering C, 61, 674-680. doi: 10.1016/j.msec.2015.12.047
Butcher, Neville J., Mortimer, Gysell M. and Minchin, Rodney F. (2016). Drug delivery: unravelling the stealth effect. Nature Nanotechnology, 11 (4), 310-311. doi: 10.1038/nnano.2016.6
Wiliem, Arnold, Hobson, Peter, Minchin, Rodney F. and Lovell, Brian C. (2015). A bag of cells approach for antinuclear antibodies HEp-2 image classification. Cytometry. Part A, 87 (6), 549-557. doi: 10.1002/cyto.a.22597
Minchin, Rodney F and Butcher, Neville J (2015). The role of lysine100 in the binding of acetylcoenzyme A to human arylamine N-acetyltransferase 1: Implications for other acetyltransferases. Biochemical Pharmacology, 94 (3), 195-202. doi: 10.1016/j.bcp.2015.01.015
Tiang, Jacky M., Butcher, Neville J. and Minchin, Rodney F. (2015). Effects of human arylamine N-acetyltransferase I knockdown in triple-negative breast cancer cell lines. Cancer Medicine, 4 (4), 565-574. doi: 10.1002/cam4.415
Tirtaatmadja, Nicolin, Mortimer, Gysell, Ng, Eng-Poh, Ahmad, Hacan Ali, Mintova, Svetlana, Serpooshan, Vahid, Minchin, Rodney F and Mahmoudi, Morteza (2015). Nanoparticles-induced inflammatory cytokines in human plasma concentration manner: An ignored factor at the nanobio-interface. Journal of the Iranian Chemical Society, 12 (2), 317-323. doi: 10.1007/s13738-014-0486-7
Tee, Nicolin, Zhu, Yingdong, Mortimer, Gysell M., Martin, Darren J. and Minchin, Rodney F. (2015). Fluoromica nanoparticle cytotoxicity in macrophages decreases with size and extent of uptake. International Journal of Nanomedicine, 10 (1), 2363-2375. doi: 10.2147/IJN.S80655
Sidharthan, Neelima P., Butcher, Neville J., Mitchell, Deanne J. and Minchin, Rodney F. (2014). Expression of the orphan cytosolic sulfotransferase SULT4A1 and its major splice variant in human tissues and cells: dimerization, degradation and polyubiquitination. PLoS One, 9 (7) e101520, e101520.1-e101520.8. doi: 10.1371/journal.pone.0101520
Stephenson, Rachel, Varamini, Pegah, Butcher, Neville, Minchin, Rodney and Toth, Istvan (2014). Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro. Nanomedicine: Nanotechnology, Biology and Medicine, 10 (8), 1799-1808. doi: 10.1016/j.nano.2014.06.015
Mortimer, Gysell M., Butcher, Neville J., Musumeci, Anthony W., Deng, Zhou J., Martin, Darren J. and Minchin, Rodney F. (2014). Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials. ACS Nano, 8 (4), 3357-3366. doi: 10.1021/nn405830g
Cheesman, Matthew J., Chen, Steven, Manchadi, Mary-Louise, Jacob, Teague, Minchin, Rodney F. and Tregloan, Peter A. (2014). Implementation of a Virtual Laboratory Practical Class (VLPC) module in pharmacology education. Pharmacognosy Communications, 4 (1), 2-10. doi: 10.5530/pc.2014.1.2
Wiliem, Arnold, Sanderson, Conrad, Wong, Yongkang, Hobson, Peter, Minchin, Rodney F. and Lovell, Brian C. (2014). Automatic classification of Human Epithelial type 2 cell Indirect Immunofluorescence images using Cell Pyramid Matching. Pattern Recognition, 47 (7), 2315-2324. doi: 10.1016/j.patcog.2013.10.014
Deng, Zhou J., Butcher, Neville J., Mortimer, Gysell M., Jia, Zhongfan, Monteiro, Michael J., Martin, Darren J. and Minchin, Rodney F. (2014). Interaction of human arylamine n-acetyltransferase 1 with different nanomaterials. Drug Metabolism and Disposition, 42 (3), 377-383. doi: 10.1124/dmd.113.055988
Zhang, Jing, Martin, Darren J., Taran, Elena, Thurecht, Kristofer J. and Minchin, Rodney F. (2014). Effect of supercritical carbon dioxide on the loading and release of model drugs from polyurethane films: comparison with solvent casting. Macromolecular Chemistry and Physics, 215 (1), 54-64. doi: 10.1002/macp.201300492
Sidharthan, Neelima P., Minchin, Rodney F. and Butcher, Neville J. (2013). Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: Role of D1 receptor-n-methyl-d-aspartate receptor coupling. Journal of Biological Chemistry, 288 (48), 34364-34374. doi: 10.1074/jbc.M113.493239
Witham, Katey L., Butcher, Neville J., Sugamori, Kim S., Brenneman, Debbie, Grant, Denis M. and Minchin, Rodney F. (2013). 5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. PLoS One, 8 (10) e77923, e77923.1-e77923.7. doi: 10.1371/journal.pone.0077923
Deng, Zhou J., Liang, Mingtao, Toth, Istvan, Monteiro, Michael and Minchin, Rodney F. (2013). Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses. Nanotoxicology, 7 (3), 314-322. doi: 10.3109/17435390.2012.655342
Sakhtianchi, Ramom, Minchin, Rodney F., Lee, Ki-Bum, Alkilany, Alaaldin M., Serpooshan, Vahid and Mahmoudi, Morteza (2013). Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity. Advances in Colloid and Interface Science, 201-202, 18-29. doi: 10.1016/j.cis.2013.10.013
Saunders, Nicholas A., Simpson, Fiona, Thompson, Erik W., Hill, Michelle M., Endo-Munoz, Liliana, Leggatt, Graham, Minchin, Rodney F. and Guminski, Alexander (2012). Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives. EMBO Molecular Medicine, 4 (8), 675-684. doi: 10.1002/emmm.201101131
Deng, Zhou J., Liang, Mingtao, Toth, Istvan, Monteiro, Michael J. and Minchin, Rodney F. (2012). Molecular interaction of poly(acrylic acid) gold nanoparticles with human fibrinogen. ACS Nano, 6 (10), 8962-8969. doi: 10.1021/nn3029953
Butcher, Neville J. and Minchin, Rodney F. (2012). Arylamine N-acetyltransferase 1: A novel drug target in cancer development. Pharmacological Reviews, 64 (1), 147-165. doi: 10.1124/pr.110.004275
Tiang, JM, Butcher, NJ, Cullinane, C, Humbert, PO and Minchin, RF (2011). RNAi-mediated knock-down of Arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition. PLoS One, 6 (2) e17031, 1-10. doi: 10.1371/journal.pone.0017031
Mitchell, Deanne J., Butcher, Neville J. and Minchin, Rodney F. (2011). Phosphorylation/dephosphorylation of human SULT4A1: Role of Erk1 and PP2A. Biochimica et Biophysica Acta - Molecular Cell Research, 1813 (1), 231-237. doi: 10.1016/j.bbamcr.2010.09.011
Deng, Zhou J., Liang, Mingtao, Monteiro, Michael, Toth, Istvan and Minchin, Rodney F. (2011). Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. Nature Nanotechnology, 6 (1), 39-44. doi: 10.1038/NNANO.2010.250
Paterson, S, Sin, KL, Tiang, JM, Minchin, RF and Butcher, NJ (2011). Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells. Drug Metabolism and Disposition, 39 (1), 77-82. doi: 10.1124/dmd.110.036202
Butcher, Neville J., Mitchell, Deanne J., Burow, Rachel and Minchin, Rodney F. (2010). Regulation of Mouse Brain-Selective Sulfotransferase Sult4a1 by cAMP Response Element-Binding Protein and Activating Transcription Factor-2. Molecular Pharmacology, 78 (3), 503-510. doi: 10.1124/mol.110.063404
Butcher, Neville J. and Minchin, Rodney F. (2010). Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1. Carcinogenesis, 31 (5), 820-826. doi: 10.1093/carcin/bgq042
Musumeci, Anthony W., Mortimer, Gysell M., Butler, Margaret K., Xu, Zhi Ping, Minchin, Rodney M. and Martin, Darren J. (2010). Fluorescent layered double hydroxide nanoparticles for biological studies. Applied Clay Science, 48 (1-2), 271-279. doi: 10.1016/j.clay.2009.11.008
Minchin, Rodney F. and Yang, Shu (2010). Endosomal disruptors in non-viral gene delivery. Expert Opinion On Drug Delivery, 7 (3), 331-339. doi: 10.1517/17425240903512931
Tiang, Jacky M., Butcher, Neville J. and Minchin, Rodney F. (2010). Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells. Biochemical and Biophysical Research Communications, 393 (1), 95-100. doi: 10.1016/j.bbrc.2010.01.087
Minchin, Rodney F and Martin, Darren J (2010). Minireview: Nanoparticles for molecular imaging - an overview. Endocrinology, 151 (2), 474-481. doi: 10.1210/en.2009-1012
Liang, Mingtao, Lin, I-Chun, Whittaker, Michael R., Minchin, Rodney F., Monteiro, Michael J. and Toth, Istvan (2010). Cellular uptake of densely packed polymer coatings on gold nanoparticles. ACS Nano, 4 (1), 403-413. doi: 10.1021/nn9011237
Musumeci, Anthony W., Schiller, Tara L., Xu, Zhi Ping, Minchin, Rodney F., Martin, Darren J. and Smith, Suzanne V. (2010). Synthesis and characterization of dual radiolabeled layered double hydroxide nanoparticles for use in in vitro and in vivo nanotoxicology studies. The Journal of Physical Chemistry Part C: Nanomaterials and Interfaces, 114 (2), 734-740. doi: 10.1021/jp905347x
Musumeci, Anthony W, Xu, Zhi Ping, Smith, Suzanne V, Minchin, Rodney F and Martin, Darren J (2010). Layered double hydroxide nanoparticles incorporating terbium: applicability as a fluorescent probe and morphology modifier. Journal of Nanoparticle Research, 12 (1), 111-120. doi: 10.1007/s11051-008-9583-9
Deng, Zhou J., Mortimer, Gysell, Schiller, Tara, Musumeci, Anthony, Martin, Darren and Minchin, Rodney F. (2009). Differential plasma protein binding to metal oxide nanoparticles. Nanotechnology, 20 (45) 455101, 455101.1-455101.9. doi: 10.1088/0957-4484/20/45/455101
Mitchell, Deanne J. and Minchin, Rodney F. (2009). Cytosolic Aryl Sulfotransferase 4A1 Interacts with the Peptidyl Prolyl Cis-Trans Isomerase Pin1. Molecular Pharmacology, 76 (2), 388-395. doi: 10.1124/mol.109.055442
Lewis, Aaron G. and Minchin, Rodney F. (2009). Lack of exonic sulflotransferase 4A1 mutations in controls and schizophrenia cases. Psychiatric Genetics, 19 (1), 53-55. doi: 10.1097/YPG.0b013e3283118776
Yang, Shu, Coles, David J., Esposito, Anna, Mitchell, Deanne J., Toth, Istvan and Minchin, Rodney F. (2009). Cellular uptake of self-assembled cationic peptide-DNA complexes: Multifunctional role of the enhancer chloroquine. Journal of controlled release, 135 (2), 159-165. doi: 10.1016/j.jconrel.2008.12.015
Butcher, Neville J., Tiang, Jacky and Minchin, Rodney F. (2008). Regulation of arylamine N-acetyltransferases. Current Drug Metabolism, 9 (6), 498-504. doi: 10.2174/138920008784892128
Hein, David W., Boukouvala, Sotiriab, Grant, Denis M., Minchin, Rodney F. and Sim, Edith (2008). Changes in consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics and Genomics, 18 (4), 367-368. doi: 10.1097/FPC.0b013e3282f60db0
Minchin, Rod (2008). Nanomedicine: Sizing up targets with nanoparticles. Nature Nanotechnology, 3 (1), 12-13. doi: 10.1038/nnano.2007.433
Mitchell, D. J. and Minchin, R. F. (2008). E. coli nitroreductase/CB1954 gene-directed enzyme prodrug therapy: role of arylamine N-acetlytransferase 2. Cancer Gene Therapy, 15 (11), 758-764. doi: 10.1038/cgt.2008.47
Minchin, Rodney F., Lewis, Aaron, Mitchell, Deanne, Kadlubar, Fred F. and McManus, Michael E. (2008). Sulfotransferase 4A1. The International Journal of Biochemistry & Cell Biology, 40 (12), 2686-2691. doi: 10.1016/j.biocel.2007.11.010
Coles, Daniel J., Yang, Shu, Esposito, Anna, Mitchell, Deanne, Minchin, Rodney F. and Toth, Istvan (2007). The synthesis and characterisation of a novel dendritic system for gene delivery. Tetrahedron, 63 (49), 12207-12214. doi: 10.1016/j.tet.2007.09.048
Butcher, Neville J., Broadhurst, Gysell M. and Minchin, Rodney F. (2007). Polyamine-dependent regulation of spermidine-spermine N-1-acetyltransferase mRNA translation. Journal of Biological Chemistry, 282 (39), 28530-28539. doi: 10.1074/jbc.M701265200
Khoshnejad, M., Young, P. R., Toth, I. and Minchin, R. F. (2007). Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery. Current Medicinal Chemistry, 14 (29), 3152-3156. doi: 10.2174/092986707782793989
Butcher, Neville J., Tetlow, Natasha L., Cheung, Catherine, Broadhurst, Gysell M. and Minchin, Rodney F. (2007). Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Research, 67 (1), 85-92. doi: 10.1158/0008-5472.CAN-06-2635
Minchin, RF, Hanna, PE, Dupret, JM, Wagner, CR, Rodrigues-Lima, F and Butcher, NJ (2007). Arylamine N-acetyltransferase I. International Journal of Biochemistry & Cell Biology, 39 (11), 1999-2005. doi: 10.1016/j.biocel.2006.12.006
Minchin, Rodney F., Knight, Samuel, Arulpragasam, Ajanthy and Fogel-Petrovic, Mirjana (2006). Concentration dependent effects of N1,N11-diethylnorspermine on melanoma cell proliferation. International Journal of Cancer, 118 (2), 509-512. doi: 10.1002/ijc.21359
Butcher, N. J., Arulpragasam, A., Goh, H. L., Davey, Tamara and Minchin, Rodney F. (2005). Genomic organization of human arylamine N-acetyltransferase Type I reveals alternative promoters that generate different 5'-UTR splice variants with altered translational activities. Biochemical Journal, 387 (1), 119-127. doi: 10.1042/BJ20040903
McCoubrie, J. E., Kendrick, T. S. and Minchin, R. F. (2004). HIV LTR-dependent expression of Bax selectively induces apoptosis in Tat-positive cells. Biochemical and Biophysical Research Communications, 325 (4), 1459-1464. doi: 10.1016/j.bbrc.2004.10.195
Carrello, A, Allan, RK, Morgan, SL, Owen, BAL, Mok, D, Ward, BK, Minchin, RF, Toft, DO and Ratajczak, T (2004). Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Cell Stress & Chaperones, 9 (2), 167-181. doi: 10.1379/CSC-26R.1
Minchin, R. F. and McCoubrie, J. E. (2004). Mutational analysis of the large periplasmic loop 7-8 of the putrescine transporter PotE in Escherichia coli. International Journal of Biochemistry & Cell Biology, 36 (2), 271-280. doi: 10.1016/S1357-2725(03)00245-0
Butcher, Neville J., Arulpragasam, Ajanthy and Minchin, Rodney F. (2004). Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine - A mechanism for the slow acetylator phenotype and substrate-dependent down-regulation. Journal of Biological Chemistry, 279 (21), 22131-22137. doi: 10.1074/jbc.M312858200
Ratajczak, T., Ward, B. K. and Minchin, R. F. (2003). Immunophilin chaperones in steroid receptor signalling. Current Topics in Medicinal Chemistry, 3 (12), 1348-1357. doi: 10.2174/1568026033451934
Butcher, NJ, Arulpragasam, A, Pope, C and Minchin, RF (2003). Identification of a minimal promoter sequence for the human N-acetyltransferase Type I gene that binds AP-1 (activator protein 1) and YY-1 (Yin and Yang 1). Biochemical Journal, 376 (2), 441-448. doi: 10.1042/BJ20030650
Kadlubar, FF, Minchin, RF, Teitel, CH, Turesky, RJ and Ilett, KF (2002). ATP-dependent kinase-catalyzed activation of N-hydroxy hetero-cyclic amines. Drug Metabolism Reviews, 34, 27-27.
Butcher, N. J., Boukouvala, S., Sim, E. and Minchin, R. F. (2002). Pharmacogenetics of the arylamine N-acetyltransferases. Pharmacogenomics Journal, 2 (1), 30-42. doi: 10.1038/sj.tpj.6500053
Kumar, P, Mark, PJ, Ward, BK, Minchin, RF and Ratajczak, T (2001). Estradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells. Biochemical And Biophysical Research Communications, 284 (1), 219-225. doi: 10.1006/bbrc.2001.4952
Minchin, RF, Carpenter, D and Orr, RJ (2001). Polyinosinic acid and polycationic liposomes attenuate the hepatic clearance of circulating plasmid DNA. Journal of Pharmacology And Experimental Therapeutics, 296 (3), 1006-1012.
Griese, Ernst-Ulricha, Ilett, Kenneth F., Kitteringham, Neil R., Eichelbaum, Michela, Powell, Helend, Spargo, Randolph M., LeSouef, Peter N., Musk, A. William and Minchin, Rodney F. (2001). Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in Aborigines from Western Australia. Pharmacogenetics, 11 (1), 69-76. doi: 10.1097/00008571-200102000-00008
Mark, PJ, Ward, BK, Kumar, P, Lahooti, H, Minchin, RF and Ratajczak, T (2001). Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock. Cell Stress & Chaperones, 6 (1), 59-70. doi: 10.1379/1466-1268(2001)006<0059:HCIAHS>2.0.CO;2
Taylor, Paul, Dornan, Jacqueline, Carrello, Amerigo, Minchin, Rodney F., Ratajczak, Thomas and Walkinshaw, Malcolm D. (2001). Two structures of cyclophilin 40: Folding and fidelity in the TPR domains. Structure, 9 (5), 431-438. doi: 10.1016/S0969-2126(01)00603-7
Kumar, P, Ward, BK, Minchin, RF and Ratajczak, T (2001). Regulation of the Hsp90-binding immunophilin, cyclophilin 40, is mediated by multiple sites for CA-binding protein (GABP). Cell Stress & Chaperones, 6 (1), 78-91. doi: 10.1379/1466-1268(2001)006<0078:ROTHBI>2.0.CO;2
Ward, BK, Kumar, P, Turbett, GR, Edmondston, JE, Papadimitriou, JM, Laing, NG, Ingram, DM, Minchin, RF and Ratajczak, T (2001). Allelic loss of cyclophilin 40, an estrogen receptor-associated immunophilin, in breast carcinomas. Journal of Cancer Research And Clinical Oncology, 127 (2), 109-115. doi: 10.1007/s004320000182
Ilett, KF, McCormick, N, Carpenter, DS, Spargo, RM, Le Souef, PN, Musk, AW and Minchin, RF (2000). Genetic polymorphisms in glutathione S-transferase M1 and T1 in an Australian Aborigine population. Pharmacogenetics, 10 (5), 477-480. doi: 10.1097/00008571-200007000-00011
Butcher, NJ, Ilett, KF and Minchin, RF (2000). Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid. Biochemical Pharmacology, 60 (12), 1829-1836. doi: 10.1016/S0006-2952(00)00501-3
Sim, E, Payton, M, Noble, M and Minchin, R (2000). An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes. Human Molecular Genetics, 9 (16), 2435-2441. doi: 10.1093/hmg/9.16.2435
Agus, C, Ilett, KF, Kadlubar, FF and Minchin, RF (2000). Characterization of an ATP-dependent pathway of activation for the heterocyclic amine carcinogen N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline. Carcinogenesis, 21 (6), 1213-1219. doi: 10.1093/carcin/21.6.1213
Butcher, NJ, Ilett, KF and Minchin, RF (2000). Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells. Molecular Pharmacology, 57 (3), 468-473. doi: 10.1124/mol.57.3.468
Minchin, R. (1999). Gene therapy for cancer using non-viral vectors: Advances and obstacles. Cancer Forum, 23 (2), 97-101.
Minchin, Rodney F., Orr, Rebecca J., Cronin, Andrew S. and Puls, Rebecca L. (1999). The pharmacology of gene therapy. Croatian Medical Journal, 40 (3), 381-391.
Dornan, A, Taylor, P, Carrello, A, Minchin, RF, Ratajczak, T and Walkinshaw, MD (1999). Purification,characterization and crystallization in two crystal forms of bovine cyclophilin 40. Acta Crystallographica Section D: Biological Crystallography, 55 (5), 1079-1082. doi: 10.1107/S0907444999003017
Puls, R. L. and Minchin, R. F. (1999). Gene transfer and expression of a non-viral polycation-based vector in CD4(+) cells. Gene Therapy, 6 (10), 1774-1778. doi: 10.1038/sj.gt.3301022
Ward, BK, Mark, PJ, Ingram, DM, Minchin, RF and Ratajczak, T (1999). Expression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer. Breast Cancer Research And Treatment, 58 (3), 267-280.
Carrello, A, Ingley, E, Minchin, RF, Tsai, S and Ratajczak, T (1999). The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and Hop is located in the dimerization domain of hsp90. Journal of Biological Chemistry, 274 (5), 2682-2689. doi: 10.1074/jbc.274.5.2682
Butcher, NJ, Ilett, KF and Minchin, RF (1998). Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by (CT)-T-190 and G(560)A mutations. Pharmacogenetics, 8 (1), 67-72. doi: 10.1097/00008571-199802000-00009
Carpenter, D. S. and Minchin, R. F. (1998). Targeting of a cholecystokinin-DNA complex to pancreatic cells in vitro and in vivo. Gene Therapy, 5 (6), 848-854. doi: 10.1038/sj.gt.3300657
Hase, CC, Minchin, RF, Kloda, A and Martinac, B (1997). Cross-linking studies and membrane localization and assembly of radiolabelled large mechanosensitive ion channel (MscL) of Escherichia coli. Biochemical And Biophysical Research Communications, 232 (3), 777-782. doi: 10.1006/bbrc.1997.6370
Cruickshank, CC, Minchin, RF, LeDain, AC and Martinac, B (1997). Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli. Biophysical Journal, 73 (4), 1925-1931. doi: 10.1016/S0006-3495(97)78223-7
Ratajczak, T, Woollatt, E, Kumar, P, Ward, BK, Minchin, RF and Baker, E (1997). Cyclophilin 40 (PPID) gene - Map position 4q31.3. Chromosome Research, 5 (2), 151-151.
Minchin, RF and Martin, RL (1997). Extracellular calcium stimulates Na+-dependent putrescine uptake in B16 melanoma cells. International Journal of Biochemistry & Cell Biology, 29 (3), 447-454. doi: 10.1016/S1357-2725(96)00145-8
Anderson, KE, Hammons, GJ, Kadlubar, FF, Potter, JD, Kaderlik, KR, Ilett, KF, Minchin, RF, Teitel, CH, Chou, HC, Martin, MV, Guengerich, FP, Barone, GW, Lang, NP and Peterson, LA (1997). Metabolic activation of aromatic amines by human pancreas. Carcinogenesis, 18 (5), 1085-1092. doi: 10.1093/carcin/18.5.1085
Cruickshank, C, Minchin, RF, LeDain, AC and Martinac, B (1997). Estimate of the pore size of the large mechanosensitive ion channel (MscL) of Escherichia coli.. Biophysical Journal, 72 (2), MPO63-MPO63.
Edwards, R. J., Carpenter, D. S. and Minchin, R. F. (1996). Uptake and intracellular trafficking of asialoglycoprotein-polylysine-DNA complexes in isolated rat hepatocytes. Gene Therapy, 3 (10), 937-940.
Butcher, N.J., Minchin, R.F., Kadlubar, F.F. and llett , K.F. (1996). Uptake of the food-derived heterocyclic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its N-hydroxy metabolite into rat pancreatic acini and hepatocytes in vitro. Carcinogenesis, 17 (4), 889-992. doi: 10.1093/carcin/17.4.889
Ratajczak, Thomas, Mark, Peter J., Martin, Roger L. and Minchin, Rodney F. (1996). Cyclosporin a potentiates estradiol-induced expression of the cathepsin D gene in MCF7 breast cancer cells. Biochemical and Biophysical Research Communications, 220 (1), 208-212. doi: 10.1006/bbrc.1996.0382
Wong, WS and Minchin, RF (1996). Binding and internalization of the melanocyte stimulating hormone receptor ligand [Nle(4), D-Phe(7)]alpha-MSH in B16 melanoma cells. International Journal of Biochemistry & Cell Biology, 28 (11), 1223-1232. doi: 10.1016/S1357-2725(96)00074-X
Minchin, R. F. (1995). Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells. Biochemical Journal, 307 (1), 1-3. doi: 10.1042/bj3070001
Ratajczak, Thomas, Carrello, Amerigo and Minchin, Rodney F. (1995). Biochemical and calmodulin binding properties of estrogen receptor binding cyclophilin expressed in Escherichia coli. Biochemical and Biophysical Research Communications, 209 (1), 117-125. doi: 10.1006/bbrc.1995.1478
Kadlubar, F, Kaderlik, R K, Mulder, G J, Lin, D, Butler, M A, Teitel, C H, Minchin, R F, Ilett, K F, Friesen, M D and Bartsch, H (1995). Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis. Princess Takamatsu symposia, 23, 207-13.
Kaderlik, Keith R., Minchin, Rodney F., Mulder, Gerard J., Ilett, Kenneth F., Daugaard-jenson, Maria, Teitel, Candee H. and Kadlubar, Fred F. (1994). Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-l-methyl-6-phenyumidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues. Carcinogenesis, 15 (8), 1703-1709. doi: 10.1093/carcin/15.8.1703
Ilett, Kenneth F., Ingram, David M., Carpenter, Denise S., Teitel, Candee H., Lang, Nicholas P., Kadlubar, Fred F. and Minchin, Rodney F. (1994). Expression of monomorphic and polymorphic N-acetyltransferases in human colon. Biochemical Pharmacology, 47 (5), 914-917. doi: 10.1016/0006-2952(94)90493-6
Minchin, R. F., Kadlubar, F. F. and Ilett, K. F. (1993). Role of acetylation in colorectal cancer. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 290 (1), 35-42. doi: 10.1016/0027-5107(93)90030-J
Ilett, Kenneth F., Chiswell, Gregory M., Spargo, Randolph M., Platt, Elanor. and Minchin, Rodney F. (1993). Acetylation phenotype and genotype in aboriginal leprosy patients from the north-west region of western Australia. Pharmacogenetics, 3 (5), 264-269. doi: 10.1097/00008571-199310000-00006
Minchin, R. F., Reeves, P. T., Teitel, C. H., McManus, M. E., Mojarrabi, B., Ilett, K. F. and Kadlubar, F. F. (1992). N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells. Biochemical and Biophysical Research Communications, 185 (3), 839-844. doi: 10.1016/0006-291X(92)91703-S
Minchin, Rodney F., Ilett, Kenneth F., Teitel, Candee H., Reeves, Philip T. and Kadlubar, Fred F. (1992). Direct oacetylation of N-hydroxy arylamines by acetylsalicylic acid to form carcinogen-DNA adducts. Carcinogenesis, 13 (4), 663-667. doi: 10.1093/carcin/13.4.663
Martin, R. B., Fisher, M. E., Minchin, R. F. and Teo, K. L. (1992). Low-intensity combination chemotherapy maximizes host survival time for tumors containing drug-resistant cells. Mathematical Biosciences, 110 (2), 221-252. doi: 10.1016/0025-5564(92)90039-Y
Martin, R. B., Fisher, M. E., Minchin, R. F. and Teo, K. L. (1992). Optimal control of tumor size used to maximize survival time when cells are resistant to chemotherapy. Mathematical Biosciences, 110 (2), 201-219. doi: 10.1016/0025-5564(92)90038-X
Reeves, P. T., Kinnear, B. F., Minchin, R. F. and Ilett, K. F. (1992). Distribution of polymorphic N-acetyltransferase in the intestines of rapid acetylator rabbits. Asia Pacific Journal of Pharmacology, 7 (3), 219-223.
Ilett, K. F., Reeves, P. T., Minchin, R. F., Kinnear, B. F., Watson, H. F. and Kadlubar, F. F. (1991). Distribution of acetyltransferase activities in the intestines of rapid and slow acetylator rabbits. Carcinogenesis, 12 (8), 1465-1469. doi: 10.1093/carcin/12.8.1465
Martin, Roger L., Ilett, Kenneth F. and Minchin, Rodney F. (1991). Cell cycle–dependent uptake of putrescine and its importance in regulating cell cycle phase transition in cultured adult mouse hepatocytes. Hepatology, 14 (6), 1243-1250. doi: 10.1002/hep.1840140646
MINCHIN, Rodney F., RASO, Albert, MARTIN, Roger L. and ILETT, Kenneth F. (1991). Evidence for the existence of distinct transporters for the polyamines putrescine and spermidine in B16 melanoma cells. European Journal of Biochemistry, 200 (2), 457-462. doi: 10.1111/j.1432-1033.1991.tb16204.x
Reeves, P T, Kinnear, B F, Minchin, R F and Ilett, K F (1991). Immunological evidence for N-acetyltransferase isozymes in the rabbit. Molecular pharmacology, 39 (1), 42-8.
Martin, Roger L., Ilett, Kenneth F. and Minchin, Rodney F. (1990). Characterisation of putrescine uptake by cultured adult mouse hepatocytes. BBA - Molecular Cell Research, 1051 (1), 52-59. doi: 10.1016/0167-4889(90)90173-B
Martin, R. B., Fisher, M. E., Minchin, R. F. and Teo, K. L. (1990). A mathematical model of cancer chemotherapy with an optimal selection of parameters. Mathematical Biosciences, 99 (2), 205-230. doi: 10.1016/0025-5564(90)90005-J
Ilett, Kenneth F., Tee, Lisa B.G., Reeves, Philip T. and Minchin, Rodney F. (1990). Mebolism of drugs and other xenobiotics in the gut lumen and wall. Pharmacology and Therapeutics, 46 (1), 67-93. doi: 10.1016/0163-7258(90)90036-2
Dilollo, D. L., Beilharz, M. W., Lai, M. C. and Minchin, R. F. (1990). Difluoromethylornithine prevents the down-regulation of type 1 interferon receptors: A possible mechanism for a synergistic antiproliferative effect. Molecular Pharmacology, 38 (4), 451-454.
Saunders, NA, McGeachie, JK, Ilett, KF and Minchin, RF (1989). Localization of Spermidine Uptake in Rabbit Lung Slices. American Journal of Physiology, 257 (3), C579-C587.
Saunders, N. A., McGeachie, J. K., Ilett, K. F. and Minchin, R. F. (1989). Localization of spermidine uptake in rabbit lung slices. American Journal of Physiology, 257 (3), C579-C587. doi: 10.1152/ajpcell.1989.257.3.C579
Saunders, NA, Ilett, KF and Minchin, RF (1989). Pulmonary Alveolar Macrophages Express a Polyamine Transport-System. Journal of Cellular Physiology, 139 (3), 624-631. doi: 10.1002/jcp.1041390324
Minchin, R. F., Martin, R. L., Summers, L. A. and Ilett, K. F. (1989). Inhibition of putrescine uptake by polypyridinium quaternary salts in B16 melanoma cells treated with difluoromethylornithine. Biochemical Journal, 262 (2), 391-395. doi: 10.1042/bj2620391
Reeves, P T, Minchin, R F and Ilett, K F (1989). In vivo mechanisms for the enhanced acetylation of sulfamethazine in the rabbit after hydrocortisone treatment. The Journal of pharmacology and experimental therapeutics, 248 (1), 348-52.
Minchin, Rodney F., Martin, Roger L. and Ilett, Kenneth F. (1989). Paraquat is not accumulated in B16 tumor cells by the polyamine transport system. Life Sciences, 45 (1), 63-69. doi: 10.1016/0024-3205(89)90436-0
REEVES, PT, MINCHIN, RF and ILETT, KF (1989). INVIVO MECHANISMS FOR THE ENHANCED ACETYLATION OF SULFAMETHAZINE IN THE RABBIT AFTER HYDROCORTISONE TREATMENT. Journal of Pharmacology and Experimental Therapeutics, 248 (1), 348-352.
Tee, Lisa B.G., Minchin, Rodney F. and Ilett, Kenneth F. (1988). Metabolism of 1, 8-dinitropyrene by rabbit lung. Carcinogenesis, 9 (10), 1869-1874. doi: 10.1093/carcin/9.10.1869
Saunders, NA, Rigby, PJ, Ilett, KF and Minchin, RF (1988). Autoradiographic Localization of Putrescine Uptake to Type-Ii Pneumocytes of Rabbit Lung Slices. Laboratory Investigation, 59 (3), 380-386.
Reeves, Philip T., Minchin, Rodney F. and Ilett, Kenneth F. (1988). Measurement of organ blood flow in the rabbit. Journal of Pharmacological Methods, 20 (3), 187-196. doi: 10.1016/0160-5402(88)90062-9
Minchin, Rodney F., Johnston, Michael R., Schuller, Hildergard M., Aiken, Michael A. and Boyd, Michael R. (1988). Pulmonary toxicity of doxorubicin administered by in situ isolated lung perfusion in dogs. Cancer, 61 (7), 1320-1325. doi: 10.1002/1097-0142(19880401)61:7<1320::AID-CNCR2820610708>3.0.CO;2-J
Reeves, P. T., Minchin, R. F. and Ilett, K. F. (1988). Induction of sulfamethazine acetylation by hydrocortisone in the rabbit. Drug Metabolism and Disposition, 16 (1), 110-115.
Saunders, NA, Ilett, KF and Minchin, RF (1987). Uptake, efflux and metabolism of the polyamine putrescine in rabbit lung slices. BBA - Molecular Cell Research, 927 (2), 170-176. doi: 10.1016/0167-4889(87)90131-5
Minchin, Rodney F. (1987). Evidence for the reversible binding of paraquat to deoxyribonucleic acid. Chemico-Biological Interactions, 61 (2), 139-149. doi: 10.1016/0009-2797(87)90035-4
Minchin, Rodney F. (1987). Inhibition of rat lung S-adenosylmethionine decarboxylase by N,N-dimethyl-4,4′- dipyridyl dichloride (paraquat). Biochemical Pharmacology, 36 (1), 179-181. doi: 10.1016/0006-2952(87)90397-2
McManus, Michael E., Minchin, Rodney F., Schwartz, Dolores M., Wirth, Peter J. and Huber, Brian E. (1986). Induction by phenobarbital in McA-RH7777 rat hepatoma cells of a polycyclic hydrocarbon inducible cytochrome P450. Biochemical and Biophysical Research Communications, 137 (1), 120-127. doi: 10.1016/0006-291X(86)91184-8
Minchin, Rodney F., Ho, Peter C. and Boyd, Michael R. (1986). Reductive metabolism of nitrofurantoin by rat lung and liver in vitro. Biochemical Pharmacology, 35 (4), 575-580. doi: 10.1016/0006-2952(86)90350-3
Minchin, Rodney F., Mcmanus, Michael E., Boobis, Alan R., Davies, Donald S. and Thorgeirsson, Snorri S. (1985). Polymorphic metabolism of the carcinogen 2-acetylaminofluorene in human liver microsomes. Carcinogenesis, 6 (12), 1721-1724. doi: 10.1093/carcin/6.12.1721
Statham, C N, Minchin, R F, Sasame, H A, Kim, S H and Boyd, M R (1985). Effects of vitamin E on the distribution and metabolism of nitrofurantoin in rats. Drug metabolism and disposition: the biological fate of chemicals, 13 (5), 532-4.
Minchin, R F, McManus, M E, Thorgeirsson, S S, Schwartz, D and Boyd, M R (1985). Metabolism of 2-acetylaminofluorene in isolated rabbit pulmonary cells. Evidence for the heterogeneous distribution of monooxygenase activity in lung tissue. Drug metabolism and disposition: the biological fate of chemicals, 13 (4), 406-11.
STATHAM, CN, MINCHIN, RF, SASAME, HA, KIM, SH and BOYD, MR (1985). EFFECTS OF VITAMIN-E ON THE DISTRIBUTION AND METABOLISM OF NITROFURANTOIN IN RATS. Drug Metabolism and Disposition, 13 (5), 532-534.
MINCHIN, RF, MCMANUS, ME, THORGEIRSSON, SS, SCHWARTZ, D and BOYD, MR (1985). METABOLISM OF 2-ACETYLAMINOFLUORENE IN ISOLATED RABBIT PULMONARY CELLS - EVIDENCE FOR THE HETEROGENEOUS DISTRIBUTION OF MONOOXYGENASE ACTIVITY IN LUNG-TISSUE. Drug Metabolism and Disposition, 13 (4), 406-411.
Mcmanus, Michael E., Minchin, Rodney F., Sanderson, Nancy, Schwartz, Dolores, Johnson, Eric F. and Thorgeirsson, Snorri S. (1984). Metabolic processing of 2-acetylaminofluorene by microsomes and six highly purified cytochrome P-450 forms from rabbit liver. Carcinogenesis, 5 (12), 1717-1723. doi: 10.1093/carcin/5.12.1717
McManus, M E, Boobis, A R, Minchin, R F, Schwartz, D M, Murray, S, Davies, D S and Thorgeirsson, S S (1984). Relationship between oxidative metabolism of 2-acetylaminofluorene, debrisoquine, bufuralol, and aldrin in human liver microsomes. Cancer research, 44 (12 Pt 1), 5692-7.
Minchin, R F, Ho, P C and Boyd, M R (1984). Effects of oxygen on the disposition of nitrofurantoin in intact rat lung. Drug metabolism and disposition: the biological fate of chemicals, 12 (6), 787-9.
Minchin, Rodney F and Hanau, Gavle R. (1984). Rapid and Simple Technique for The Quantitation of Polyamines in Biological Samples. Journal of Liquid Chromatography, 7 (13), 2605-2610. doi: 10.1080/01483918408067028
Minchin, R F, Johnston, M R, Aiken, M A and Boyd, M R (1984). Pharmacokinetics of doxorubicin in isolated lung of dogs and humans perfused in vivo. The Journal of pharmacology and experimental therapeutics, 229 (1), 193-8.
Christensen, C., Dawson, C. and Minchin, R. (1984). Pulmonary endothelial function is preserved during in vivo lung perfusion in dogs. Federation Proceedings, 43 (4)
MCMANUS, ME, BOOBIS, AR, MINCHIN, RF, SCHWARTZ, DM, MURRAY, S, DAVIES, DS and THORGEIRSSON, SS (1984). RELATIONSHIP BETWEEN OXIDATIVE-METABOLISM OF 2-ACETYLAMINOFLUORENE, DEBRISOQUINE, BUFURALOL, AND ALDRIN IN HUMAN-LIVER MICROSOMES. Cancer Research, 44 (12), 5692-5697.
MINCHIN, RF, JOHNSTON, MR, AIKEN, MA and BOYD, MR (1984). PHARMACOKINETICS OF DOXORUBICIN IN ISOLATED LUNG OF DOGS AND HUMANS PERFUSED INVIVO. Journal of Pharmacology and Experimental Therapeutics, 229 (1), 193-198.
Mcmanus, M. E., Minchin, R. F., Sanderson, N. D., Wirth, P. J. and Thorgeirsson, S. S. (1983). Kinetic evidence for the involvement of multiple forms of human liver cytochrome P-450 in the metabolism of acetylaminofluorene. Carcinogenesis, 4 (6), 693-697. doi: 10.1093/carcin/4.6.693
Minchin, Rodney F. and Boyd, Michael R. (1983). Uptake and metabolism of doxorubicin in isolated perfused rat lung. Biochemical Pharmacology, 32 (18), 2829-2832. doi: 10.1016/0006-2952(83)90102-8
McManus, M E, Minchin, R F, Sanderson, N, Wirth, P J and Thorgeirsson, S S (1983). Kinetics of N- and C-hydroxylations of 2-acetylaminofluorene in male Sprague-Dawley rat liver microsomes: implications for carcinogenesis. Cancer research, 43 (8), 3720-4.
Johnston, Michael R., Minchin, Rodney, Shull, James H., Thenot, Jean Paul, McManus, Bruce M., Terrill, Richard and Boyd, Michael R. (1983). Isolated lung perfusion with adriamycin. A preclinical study. Cancer, 52 (3), 404-409. doi: 10.1002/1097-0142(19830801)52:3<404::AID-CNCR2820520304>3.0.CO;2-J
Minchin, R F and Boyd, M R (1983). Localization of metabolic activation and deactivation systems in the lung: significance to the pulmonary toxicity of xenobiotics. Annual review of pharmacology and toxicology, 23 (1), 217-38. doi: 10.1146/annurev.pa.23.040183.001245
Boyd, Michael R., Grygiel, John J. and Minchin, Rodney F. (1983). METABOLIC ACTIVATION AS A BASIS FOR ORGAN‐SELECTIVE TOXICITY. Clinical and Experimental Pharmacology and Physiology, 10 (1), 87-99. doi: 10.1111/j.1440-1681.1983.tb00175.x
MCMANUS, ME, MINCHIN, RF, SANDERSON, N, WIRTH, PJ and THORGEIRSSON, SS (1983). KINETICS OF N-HYDROXYLATIONS AND C-HYDROXYLATIONS OF 2-ACETYLAMINOFLUORENE IN MALE SPRAGUE-DAWLEY RAT-LIVER MICROSOMES - IMPLICATIONS FOR CARCINOGENESIS. Cancer Research, 43 (8), 3720-3724.
Minchin, R F, Barber, H E and Ilett, K F (1982). Effect of prolonged desmethylimipramine administration on the pulmonary clearance of 5-hydroxytryptamine and beta-phenylethylamine in rats. Drug metabolism and disposition: the biological fate of chemicals, 10 (4), 356-60.
Minchin, R. F. and Ilett, K. F. (1982). Presystemic elimination of drugs: Theoretical considerations for quantifying the relative contribution of gut and liver. Journal of Pharmaceutical Sciences, 71 (4), 458-460. doi: 10.1002/jps.2600710423
Ilett, K. F., Minchin, R. F. and Papadimitriou, J. M. (1982). Accumulation of basic amine drugs in lung tissue from man and four animal species. Clinical and Experimental Pharmacology and Physiology, 9 (4), 426-427.
McManus, M. E., Minchin, R. F. and Sanderson, N. (1982). Kinetic evidence for the involvement of multiple forms of cytochrome P-450 in the metabolism of acetylaminofluorene (AAF). Federation Proceedings, 41 (4)
MINCHIN, RF, BARBER, HE and ILETT, KF (1982). EFFECT OF PROLONGED DESMETHYLIMIPRAMINE ADMINISTRATION ON THE PULMONARY CLEARANCE OF 5-HYDROXYTRYPTAMINE AND BETA-PHENYLETHYLAMINE IN RATS. Drug Metabolism and Disposition, 10 (4), 356-360.
Minchin, R. F., Ilett, K. F. and Madsen, B. W. (1981). Effect of desmethylimipramine on tissue distribution and anorectic activity of chlorphentermine in rats. Life Sciences, 28 (17), 1931-1938. doi: 10.1016/0024-3205(81)90301-5
Minchin, Rodney F., Ilett, Kenneth F. and Madsen, Barry W. (1981). A compartmental model for the uptake of chlorphentermine in isolated perfused rat lung. European Journal of Drug Metabolism and Pharmacokinetics, 6 (2), 127-133. doi: 10.1007/BF03189479
Worland, P., Minchin, R. F. and Ilett, K. F. (1981). Effect of basic amine drugs on the metabolism of angiotensin I in rat lung homogenates. Journal of Pharmacy and Pharmacology, 33 (1), 794-795. doi: 10.1111/j.2042-7158.1981.tb13936.x
Minchin, Rodney F. and Ilett, Kenneth F. (1981). Comparative uptake of quinine and quinidine in rat lung. Journal of Pharmacy and Pharmacology, 33 (1), 464-466. doi: 10.1111/j.2042-7158.1981.tb13835.x
Ilett, K. F., Barber, H. E. and Minchin, R. F. (1981). Effects of desmethylimipramine on the disposition of 5-hydroxytryptamine, β-phenylethylamine and propranolol in rat lung. Clinical and Experimental Pharmacology and Physiology, 8 (6)
Minchin, R. F. and Madsen, B. W. (1981). Structural requirements of chlorphentermine-binding inhibitors in rat lung subcellular fractions. Clinical and Experimental Pharmacology and Physiology, 8 (6)
Minchin, Rodney F. and Madsen, Barry W. (1980). Inhibition of chlorphentermine binding in rat lung: Application of connectivity theory. Life Sciences, 27 (12), 1041-1046. doi: 10.1016/0024-3205(80)90027-2
Minchin, R. F., Ilett, K. F. and Madsen, B. W. (1980). Effect of desmethylimipramine on the anorectic activity and tissue distribution of chlorphentamine in rats. Clinical and Experimental Pharmacology and Physiology, 7 (6), 672-673.
Minchin, R F, Madsen, B W and Ilett, K F (1979). Effect of desmethylimipramine on the kinetics of chlorphentermine accumulation in isolated perfused rat lung. The Journal of pharmacology and experimental therapeutics, 211 (3), 514-8.
Minchin, Rodney F., Ilett, Kenneth F. and Madsen, Barry W. (1979). Chlorphentermine binding in rat lung subcellular fractions and its displacement by desmethylimipramine. Biochemical Pharmacology, 28 (15), 2273-2278. doi: 10.1016/0006-2952(79)90689-0
Minchin, R. F., Ilett, K. F. and Madsen, B. W. (1979). Binding interaction of chlorphentermine and desmethylimipramine in rat lung subcellular fractions. Clinical and Experimental Pharmacology and Physiology, 6 (6), 685-686.
MINCHIN, RF, MADSEN, BW and ILETT, KF (1979). EFFECT OF DESMETHYLIMIPRAMINE ON THE KINETICS OF CHLORPHENTERMINE ACCUMULATION IN ISOLATED PERFUSED RAT LUNG. Journal of Pharmacology and Experimental Therapeutics, 211 (3), 514-518.
Minchin, Rodney F., Ilett, Kenneth F. and Paterson, James W. (1978). Antiarrhythmic potency of procainamide and N-acetylprocainamide in rabbits. European Journal of Pharmacology, 47 (1), 51-56. doi: 10.1016/0014-2999(78)90373-4
Minchin, R., Ilett, K. F. and Paterson, J. W. (1978). Anti-arrhythmic effect of N-acetyl procainamide. Clinical and Experimental Pharmacology and Physiology, 5 (3)
Conference Papers
Li, P., Minchin, R. F. and Butcher, N. (2019). Regulation of MMP9 expression by human arylamine N-acetyltransferase (NAT1) via Hif-1a. ESMO Breast Cancer, Berlin, Germany, 2-4 May 2019 . Amsterdam, Netherlands: Elsevier.
Minchin, Rodney F. and Butcher, Neville J. (2014). Targeting the Arylamine N-Acetyltransferases in Cancer. 10th International Meeting of the International Society for the Study of Xenobiotics (ISSX), Toronto, Canada, 29 September - 03 October 2013. New York, United States: Informa Healthcare.
Wiliem, Arnold, Hobson, Peter, Minchin, Rodney F. and Lovell, Brian C. (2011). An automatic image based single dilution method for end point titre quantitation of antinuclear antibodies tests using HEp-2 cells. 2011 International Conference on Digital Image Computing: Techniques and Applications (DICTA 2011), Noosa, QLD, Australia, 6 - 8 December 2011. Piscatawa, NJ, United States: IEEE Computer Society. doi: 10.1109/DICTA.2011.9
Musumeci, Anthony, Broadhurst, Gysell, Smith, Suzanne, Xu, Zhi P., Minchin, Rodney F. and Martin, Darren J. (2009). Radiolabeled clay nanoparticles for toxicological investigations. 8th World Biomaterials Conference, Amsterdam, The Netherlands, 28 May 2008 - 1 June, 2008. Red Hook, N.Y. U.S.A.: Curran Associates, Inc..
Coles, Daniel J., Yang, Shu, Minchin, Rodney F. and Toth, Istvan (2008). The characterization of a novel dendritic system for gene delivery by isothermal titration calorimetry. New York, N.Y.: John Wiley & Sons Ltd. doi: 10.1002/bip.21019
Coles, D., Yang, S., Esposito, A., Mitchell, D., Minchin, R. and Toth, I. (2007). The Characterisation of Novel Dendritic Carriers with DNA by Isothermal Titration Calorimetry. 4th International Peptide Symposium, Cairns, 21-25 October 2007. Australia: Australian Peptide Association.
Coles, D. J., Yang, S, Esposito, A., Mitchell, D J, Minchin, R F and Toth, I (2006). The synthesis of a novel dendritic system for gene delivery. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 24 November 2006.
Khoshnejad, M., Toth, I., Young, P. R. and Minchin, R. F. (2006). Modified influenza virosomes for gene delivery. Brisbane Biological & Organic Chemistry Symposium, Brisbane, Qld, 24 Nov 2006.
Yang, S, Coles, D. J., Esposito, A., Mitchell, D J, Toth, I and Minchin, R F (2006). Uptake of a multi-component non-viral gene delivery system and gene expression in mammalian cells. Annual Conference of the Australasian Pharmaceutical Science n, Adelaide, 3-5 December, 2006.
Coles, D. J., Yang, S., Esposito, A., Mitchell, D. J., Minchin, R. F. and Toth, I. (2006). The synthesis of a novel dendritic system for gene delivery. Annual Conference of the Australasian Pharmaceutical Science Association, Adelaide, Australia, 3-5 December, 2006.
Minchin, Ron (2004). Arylamine N-acetyltransferase - from xenobiotic metabolising enzyme to regulation of transcription. The British Toxicology Society Annual Congress 2003, Nottingham, UK, 1st - 4th September, 2003. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.tox.2004.06.030
Kendrick, T., Mus, A. M., Minchin, R., Leedman, P. and Klinken, P. (2004). The chromatin remodeller ATRX is a thyroid hormone responsive gene with a potential role as a repressor of erythropoiesis. Annual Meeting of the American Society for Biochemistry and Molecular Biology/8th Congress of the International Union for Biochemistry and Molecular Biology, Boston, MA, 12-16 Jun 2004. Bethesda, MD: Federation of American Societies for Experimental Biology.